Molecules interacting with ABCA1

ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the Phospholipid-transporting ATPase or cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene.[5] This transporter is a major regulator of cellular cholesterol and phospholipid homeostasis.

In ChEMBL, 19 predicted SARS active compounds interact with one single ABCA1 target expressed in mammals. 
These 19 compounds have been classified in 2 different chemical clusters from the chemical clustering carried out with the 64k total predicted active molecules.

Molecular interactions of all ABCA1 active molecules. No additional interaction with other proteins is recorded in ChEMBL.


Despite the lack of promiscuity of the ABCA1 & SARS active molecules, the tree map shows the low specificity of the two molecular clusters to which they belong, based on how many compounds hit on ABC1  vs the total number of compounds that have molecular interaction records in ChEMBL for each cluster.

These clusters are highlighted in the scatter plot representing SARS predicted or actual potency vs total number of molecules per cluster.

The box plot represents the distribution of SARS score for each cluster.

Schema of annotations associated to each structure