Projects

Find here machine learning exercises published by drTarget so far.

Select phenotypic or target based screens

By Emw (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons

By We Are Covert – We Are Covert, Copyrighted free use

By Ian P Newton & Paul L Appleton - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=45221234

MCF-7 breast cancer cell line (By Ian P Newton & Paul L Appleton – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=45221234)

By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute [Public domain], via Wikimedia Commons

P53 DNA binding domain By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute [Public domain], via Wikimedia Commons

By Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute – http://www.ebi.ac.uk/pdbe-srv/view/images/entry/1oqc600.png, displayed on http://www.ebi.ac.uk/pdbe-srv/view/entry/1oqc/summary, Public Domain, https://commons.wikimedia.org/w/index.php?curid=5902148

drTarget portfolio is composed of 105 programs suitable for machine learning
on the basis of the amount of information available in ChEMBL & PChem. 
See drTarget programs: assay type vs disease & therapeutic area.
Colors, sizes and shapes based on tractability and type of study as described in legend. 

 

drTarget portfolio treeMap hierarchizez by therapeutic area, disease and target.
Colors and sizes based on tractability as described in legend. 

 

 20 out of 105 programs have completed virtual screenings, followed by subsequent network analysis.
Four more programs show promising prospective analytics.

check programs in drTarget portfolio table
areadiseaseprogramassayassayTypeassayModeaddTasksleveltractabilityPoCMLmodelsvirtualScreeningTID/assayIDpathwaysAnalysisgraphsGenerationliteratureCheckwebPublication
cancerbreast cancerBrCa cell lines8 cell line screens at ChEMBLcellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted
cancerbreast cancerBRCA1 activationqHTS Assay to Identify Small Molecule Activators of BRCA1 ExpressionexpressionReportertarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancerbreast cancerBrCaAvgavg of cell line screens at ChEMBLcellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletedcompleted
cancercancerAKT1 phosphorylationHTS Assay for Inhibitors of Akt Phophorylation: Primary Screenphosphorylation-HTRFtarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancercancerALR inhibitorsHTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSenzymeActtarget-basedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablecompletedstartednotStarted
cancercancerATAD5qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1expressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartedunderway
cancercancerHSP90AA1 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90)enzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancercancerNrf2 inhibitorsNrf2 qHTS screen for inhibitorsexpressionReportertarget-basedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaynotStarted
cancercancerP53qHTS assay for re-activators of p53 using a Luc reporterexpressionReportertarget-basedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted
cancercancerPeg3HTS Assay for Peg3 Promoter InhibitorsexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancercancer, poor prognosis EGFR overexpressing tumoursADAM17QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17.enzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancercolon cancerCoCa cell lines9 cell line screens at ChEMBLcellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedunderwayunderwayunderwayunderway
cancerleukemiaMenin-MLLqHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant PeptidePPItarget-basedassayID2prospective analytics successfulcompletedcompletedcompletednotStartednotStartednotStartednotStartednotStarted
cancerleukemiamyeloid differentiationHTS to identify compounds that promote myeloid differentiation with MLPCN compound setexpressionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancerlung cancerLuCa cell lines11 cell line screens at ChEMBLcellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
cancermelanomaMITF inhibitorsAlphaScreen-based biochemical high throughput primary assay to identify inhibitors of microphthalmia-associated transcriptionfactor (MITF)alphaScreentarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cancerReactivate the silenced genes in cancer cellsMBD2TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotideFRET bindingtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cellMechanismsautophagyATG4BuHTS fluorescent assay for identification of inhibitors of ATG4BenzymeActtarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cellMechanismsautophagyautophagy imaging assayHigh-content cell-based screening for modulators of autophagyimaging localizationphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
cellMechanismscytotoxicitycytotoxcell growth assays at ChEMBLcellGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted
cellMechanismsepigeneticsbromodomain AZ2BqHTS Assay for Inhibitors of BAZ2BalphaScreentarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cellMechanismsepigeneticsE92 histone-lys N-methyltransferase 2qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9aalphaScreentarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cellMechanismsepigeneticsJmjd2aqHTS Assay for Inhibitors of JMJD2A-Tudor DomainalphaScreentarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
cellMechanismsLipid transportScarb1HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activityuptaketarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneautoimmune disordersRorcqHTS for inhibitors of ROR gamma transcriptional activityexpressionReportertarget-basedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletednotStarted
immuneautoimmune disordersRorcqHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathwayexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneCOPDAntioxidant Response ElementqHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: SummaryexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneCOPDNrf2 activatorsqHTS of Nrf2 ActivatorsexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosis Lung Fibroblast ProliferationHuman Lung Fibroblast Proliferation AssayproliferationphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisALR activatorsHTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSenzymeActtarget-basedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablenotStartednotStartednotStarted
immunefibrosisMSRAAbsorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA)enzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisNCF1uHTS of small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) NADPH oxidases regulatory proteinbindingFPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisrelaxin agonistsqHTS Assay for Agonists of the Relaxin Receptor RXFP1cAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisrelaxin PMsqHTS Assay for Antagonists of the Relaxin Receptor RXFP1 Taking the negative queue for PMscAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisSMAD3HTS of Smad transcription factor inhibitorsbindingFRETtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immunefibrosisTGF-bqHTS for Inhibitors of TGF-bGFP ligand internalizationtarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneimmunomodulationCTL granule exocytosisFlow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound LibraryCTL granule exocytosisphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneimmunomodulationSTAT1 activationPrimary cell-based high throughput screening assay to measure STAT1 activationexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneimmunomodulationSTAT3 activationPrimary cell-based high throughput screening assay to measure STAT3 activationexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneimmunomodulationSTAT3 inhibitionPrimary cell-based high throughput screening assay to measure STAT3 inhibitionexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
immuneInflammation CASP COPDIL-1b InflammasomeqHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary ScreenIL-1B productionphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
infectiousantibacterialsantibacterial11 gram + & - bacterial strains at ChEMBLcellDeathphenotypicTID3virtual screening, targetID and repurposing completedcompletedcompletedcompletedunderwaynotStartedunderwaynotStartednotStarted
infectiousantibacterialsTBseveral TB strainscellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
infectiousantifungalantifungal efflux pumps inhibitorsPhenotypic HTS multiplex for antifungal efflux pump inhibitorscellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantifungalfluconazole-resistant C.albicansFluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compoundcellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantifungaltRNA 2'-phosphotransferaseFluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1).enzymeActtarget-basedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantifungalVMA11HTS of Small Molecules that Regulate V-ATPase Proton Transport in Yeast using pHLuorinpHSensitiveDyephenotypicTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralSARS-CoVPLP&3CLP proteasesPChem screens plus phenotypic records @ ChEMBLproteases& cellDeathphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletedcompleted
infectiousantiviralhCMVqHTS Assay for inhibitors of the human cytomegalovirus (HCMV)InfectionReporterphenotypicTID0under evaluationnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralHCV inhibitorsqHTS Assay for Inhibitors of Hepatitis C Virus (HCV)InfectionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralHIV fussionHIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_ActivitycellFussionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralNS1Discovery of Small Molecule Probes for H1N1 Influenza NS1AalphaScreentarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralNS1qHTS Assay for Inhibitors of Influenza NS1 Protein FunctioncellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralPSIP1TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA IntegrationFRET bindingtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralRSVA Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV)cellDeathphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralvifHigh Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interactionFRET bindingtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousantiviralvprqHTS Assay for Inhibitors of the HIV-1 protein VprcellDeathtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiouschagasT. Cruzi replicationLuminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi ReplicationcellGrowthphenotypicTID2prospective analytics successfulnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousleishmaniasisLeishmania promastigoteLeishmania major promastigote HTScellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaP. Falciparum erythrocyte 3D7NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assaycellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaP. falciparum 3d7Inhibition of P. falciparum 3D7cellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaP. falciparum Dd2Inhibition of P. falciparum Dd2cellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaP. falciparum erythrocyte W2NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assaycellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaPlasmodium cell deathPrimary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubationcellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousmalariaPlasmodium delayed death (apicoplast)Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubationcellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectiousprionDiseasePRNPTRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC)expressionphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectioustrypanosomiasismet-tRNA syntLuminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS)enzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
infectioustrypanosomiasisT. bruceiqHTS of Trypanosoma Brucei InhibitorscellDeathphenotypicTID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted
metabolismEnergy balance, obesityMC4RLuminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4RbArr biased transductiontarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolismEnergy balance, obesityOrexin 1FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1)IP1/[Ca++]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolismEnergy balance, obesityRev-erb AlphauHTS identification of small molecule modulators of Rev-erb Alpha.FP bindingtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolisminsulin sensitizationNR2F2Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2)expressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolisminsulin sensitizationRXRAqHTS assay to identify small molecule agonists of the RXR signaling pathway:expressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolismobesity, diabetes, and cardiovascular diseaseABHD5Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5)E.complementation PPI bindingtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
metabolismT1Diabetesb cell apoptosisLuminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell ApoptosiscellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted
metabolismT2DiabetesGlucose-dependent insulin secretionLuminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activitysecretion-associated reporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersanxietygalanin receptor antagonistsFluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3)cAMP-coupled CNG channel: MPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersanxietyNPS receptor antagonistsqHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal TransductioncAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersanxietyNPY1 receptor antagonistsPrimary cell-based high-throughput screening assay for antagonists of NPY-Y1cAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersanxietyTRH receptor enhancersqHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Enhancers[Ca++]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersdrug addictiondopamine transporterHigh Throughput Screening for Cocaine Antagonists: Primary Screenuptaketarget-basedassayID2prospective analytics successfulnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersschizophreniaD(3) dopamine receptorqHTS of D3 Dopamine Receptor Antagonist: qHTScAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersschizophreniaKCNH2qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS[Tl+]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersschizophreniaTAAR1Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1)[Ca++]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
mood disordersschizophreniaWnt/Beta-catenin pathwayWnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_ActivityexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADAPPPrimary screen for compounds that activate Alzheimer's amyloid precursortranslationphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADAPPPrimary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translationtranslationphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADArfgap1Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1)enzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADCHRM4Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4)[Ca++]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADMAPTqHTS for Inhibitors of Tau Fibril Formation, Thioflavin T BindingDFLINT aggregationtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADSLC5A7 choline transporterPrimary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT)Ch-transport-coupled Na+ flow: MPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationADTTRLuminescence-based cell-based primary high throughput screening assay to identify activators of Transthyretin (TTR) transcriptiontranscriptionphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationALSTDP-43qHTS of TDP-43 InhibitorsyeastReportertarget-basedTID3records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationALS, AD, neurodegenerationmPTPuHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assayabsorbance swellingtarget-basedTID2records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationALS, AD, neurodegenerationNFKB1High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary ScreenexpressionReportertarget-basedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaynotStarted
neurodegenerationALS, AD, neurodegenerationP97 ATPasePrimary biochemical high-throughput screening assay to measure P97 ATPase inhibitionenzymeActtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationHD, AD, PD, ALS, neurodegenerationHeat shock 70kDa protein 1APrimary cell-based high-throughput screening assay to identify transcriptional activators of heat shock protein 70 (Hsp70)expressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
neurodegenerationPDD1Allosteric Modulators of D1 Receptors: Primary ScreencAMP reportertarget-basedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablecompletednotStartednotStarted
neurodegenerationPDTAAR1Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1)[Ca++]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasescystic fibrosisAno1Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A)[Cl-]itarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasescystic fibrosisCFTRIdentification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_SinglePoint_HTS_ActivitycorrectionphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
rare diseasesMcCune-Albright syndrome (MAS)GNASqHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTScAMPtarget-basedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasesmuscularDistrophyCGAqHTS for Activators of Integrin-Mediated Alleviation for Muscular DystrophyexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasesNiemann Pick Type C (NPC)NPC1qHTS Assay for NPC1 Promoter ActivatorsexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasesNiemann Pick Type C (NPC)RAB9AqHTS Assay for Rab9 Promoter ActivatorsexpressionReportertarget-basedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted
rare diseasesSMASMN2qHTS Assay for Enhancers of SMN2 Splice Variant ExpressionexpressionReportertarget-basedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway