From phenotypic screens we get a good inference about the further efficacy that our molecules can achieve. But phenotypes, i.e. systems, cells, tissues are composed of networks of biomolecules mutually interacting, and often, it becomes hard to identify the key molecular target responsible for the observed efficacy. Biologists and chemists have developed a number of systems to determine this, but often face problems with capacity and unforeseen interactions that make the outcome slow and less than complete. In silico analysis of the overall activity of molecules, that have been assayed in a particular phenotypic assay, may show up proteins/genes that we didn´t expect to occur. We’ll fill this section with the examples below.