P53 Pathways Analysis

Pathways analysis with the P53 dataset.

Once targets are selected in the target ID section, we can proceed incorporating the pathways from Reactome database (Keggs and others would suit as well), in this case Reactome low level pathways.

 

The P53 scores are now aggregated by pathway, and there is a pathway potency score calculated too. Below a selection of best combinations of both scores.

 

And the respective barchart with the scores sorted by potency…

 

t may be also be interesting to consider how many proteins appear in the identified pathways…

Using graph databases for pathways analysis.

What we have now is a collection of target-pathway pairs accompanied by a series of numerical and class descriptors. We can track the relationships among all pair members and quantify and categorize them using the descriptors as weights and labels. This is what graph databases do, and we can always query the database for components and properties.

This is the aspect that the whole set of relationships between targets and pathways has, but the graphs can be queried by potency of nodes, or proximity to a particular node. We can see it in the next graphs.

P53 Target-pathways relations graph. All active nodes.

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Once the graph is set up, it can be queried in different modes, as below, by connection to P53 or aggregated potency.

P53 target-pathways relations graph. Connected to P53.


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P53 target-pathways relations graph. Most potent nodes.

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We can also try some segmentation of relations to identify the most important connection clusters

And explore each cluster separately…

Module 45: GPCR signalling related pathways.

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Module 19, an unique pathway: Assembly of active LPL & LIPC lipase complexes.

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Module 57: Connected intracellular kinase cascade pathways.

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Module 18: Several weakly connected transcription signalling pathways.

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Module 61: P53 connected pathways.

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Module 28: Some inflammatory pathways.

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Modules 22-72 Tubulin aggregation and protein degradation pathways.

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Module 23: Some more inflammatory pathways.

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P53 Pathways Table

pathwaypathwayIDCountActualCountPredictedp53ScorePredictedActualp53ScorePredictedtargetScorecountRatioRpartcountRatioRFcountRatioAvgRpartRFcombinedPredictionScoreAvgPathwayScorecountTotalcountMoleculestargetRecordedInPathwayMostCommon(uniprot)MostCommon(proteinName)MostCommon(Protein names)MostCommon(Gene names)MostCommon(targetName)nodeType
Abacavir transmembrane transportR-HSA-216151725524843.3827392283.3365209214.969499730.8694346570.5416080360.7055213475.1031463815.831055387884.2547.85pathway
ABC-family proteins mediated transportR-HSA-382556542108363.890329623.8796329055.1703749990.7454611630.5537128160.6495869895.509564485.627356471285.910448169.820895536pathway
Activation of anterior HOX genes in hindbrain development during early embryogenesisR-HSA-56174721696131083.499036883.4379008735.3151712240.7382360780.4737818490.6060089633.9884339415.2064053821997.521739643.652173915pathway
Activation of DNA fragmentation factorR-HSA-21122753213363.7117864873.6893115114.6913984970.9879485810.6040910680.7960198246.743696226.5440609911009342pathway
Activation of NF-kappaB in B cellsR-HSA-11690915867185063.8074790113.8005748395.1739348130.7930599840.5162289630.6546444745.4917607095.6334561611693.106061369.287878829pathway
Adenylate cyclase activating pathwayR-HSA-17066013494.0030618493.9370897066.3556138730.8333333330.6442307690.7387820516.2894121016.259567625244.846153826.923076929pathway
Adenylate cyclase inhibitory pathwayR-HSA-17067069263.830704643.7728805876.0900376610.7888888890.6428694160.7158791525.8008648776.049429229220.231.0666666711pathway
Adrenaline signalling through Alpha-2 adrenergic receptorR-HSA-392023140140733.3341083633.327112324.6956149580.9337107470.4288943470.6813025474.6141073285.6533864351347.222222608.22222223pathway
Adrenaline,noradrenaline inhibits insulin secretionR-HSA-40004297936643.3670353923.3616859895.2394408260.8472004650.4973685410.6722845034.5789279265.604241814662.5625290.18758pathway
AdrenoceptorsR-HSA-3906963489150133.2374321773.2317725775.13386620.8067327960.4601000520.6334164244.0012007135.3019202161275.5660.78571439pathway
AKT-mediated inactivation of FOXO1AR-HSA-21116311781833.1623856943.1615581744.8713575590.9979655090.2764324840.6371989963.869841835.3021218741550.2857141185.7142864pathway
Androgen biosynthesisR-HSA-19304819068503.5841787043.5391170744.9443444140.3715427790.84505020.608296493.9060665445.250036165292.9275.68pathway
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-98316835170174.0792149354.0269413924.9864512080.7836635080.5126885030.6481760065.8322875725.6809116821469.611111136.444444429pathway
APC/C:Cdc20 mediated degradation of SecurinR-HSA-17415426769174.1155309334.1082071455.1411194570.9111111110.470961930.691036526.4546624165.978753781758.288889159.644444421pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1R-HSA-1741781937161864.0175266144.0071032435.209997330.884613280.4711567450.6778850126.1304063475.8584089541877.816327369.857142924pathway
Aryl hydrocarbon receptor signallingR-HSA-893714417813543.3764849893.2643126714.7376647050.8249719240.4617967790.6433843514.3411534145.414724005760.253833pathway
Asymmetric localization of PCP proteinsR-HSA-460887027169364.1173243964.1085438575.1082218760.8936170210.4856354420.6896262326.3935997765.9699496771683.957447153.340425523pathway
ATF4 activates genesR-HSA-3809942291564.4106501434.3819221915.8811268470.3234767030.8691756270.5963261654.636471655.44572448136.3333333128.33333333pathway
AUF1 (hnRNP D0) binds and destabilizes mRNAR-HSA-450408142273024.1137532834.0703863285.0605482990.8570848380.5065706920.6818277656.2672190615.916769531652.734694178.040816325pathway
Autodegradation of Cdh1 by Cdh1:APC/CR-HSA-17408425565814.1140525554.106402025.1378840390.9069767440.4728370120.6899068786.4308165335.9707300391741.976744158.976744219pathway
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494251161280064.1235446434.08720925.1485609250.8367346940.5105397020.6736371986.176260595.8654295351921.755102400.367346923pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersR-HSA-1114532417253.0529268742.9659974966.0830990280.7956381170.64458930.7201137084.4599873355.818400347541.75437.253pathway
Budding and maturation of HIV virionR-HSA-1625882074093.9806010943.8562748394.9448341650.5221393030.6560330020.5890861534.2573222985.254108054143082pathway
Cam-PDE 1 activationR-HSA-111957325533.3922949483.3707940535.2999366540.5952380950.6713937850.633315944.1476802615.3528712597.7142857183.571428574pathway
Carboxyterminal post-translational modifications of tubulinR-HSA-8955332368321703.5589694543.5613956535.3962187820.8656022480.5560701620.7108362055.1605494095.92523118422598.62857929.657142915pathway
Cdc20:Phospho-APC/C mediated degradation of Cyclin AR-HSA-174184369123843.8871387443.8810008955.3467706020.8143518150.5047669930.6595594045.680792245.6927756091568.214286227.732142924pathway
CDK-mediated phosphorylation and removal of Cdc6R-HSA-69017340119483.96434093.9573994165.2642391450.8681832470.4775036410.6728434445.9892316115.807069931692.647059240.941176522pathway
CDT1 association with the CDC6:ORC:origin complexR-HSA-68827677380904.1200899724.1034985435.1394953330.8918941530.481541710.6867179326.3847230865.9514828681954.456522323.108695722pathway
Cellular hexose transportR-HSA-1892003034603.3297647313.3284360615.2841082410.5579873690.6887935050.6233904373.8825199355.265857826559.4285714498.57142867pathway
Cholesterol biosynthesis via desmosterolR-HSA-680704714973.4524810893.4421570894.8058650940.750.4696529930.6098264963.8701327435.21633700668.527.752pathway
Cilium AssemblyR-HSA-5617833250269433.5279169233.5300830125.4329151930.902259180.5149456660.7086024235.0891212215.8999884622912.105261431.21052615pathway
CLEC7A (Dectin-1) signalingR-HSA-56077645960222373.9046359753.8788159475.0690105460.7639791420.4880272950.6260032195.2990258295.4749001161695.661765414.661764735pathway
CLEC7A/inflammasome pathwayR-HSA-5660668544137253.7457213873.7157834894.964013140.7625161840.6022577210.6823869525.3474197915.7978201453971.81833.23pathway
COPI-dependent Golgi-to-ER retrograde trafficR-HSA-6811434354172473.2402761243.2270733374.8456680550.5764466560.6922809760.6343638164.0113567785.30918414914182.60714628.607142925pathway
COPI-independent Golgi-to-ER retrograde trafficR-HSA-6811436185162653.5649867633.5669073055.4053409170.8075690410.5806118450.6940904434.9730430365.81559854220824.36842865.789473716pathway
COPI-mediated anterograde transportR-HSA-6807878187161293.639960453.6420267535.2933612280.8074019670.5648222610.6861121144.9413583135.7874009119777.8815.817pathway
CREB phosphorylation through the activation of Adenylate CyclaseR-HSA-4427206235313.7466805553.660117765.6414423550.8515888380.5201551790.6858720085.2645756855.821373573871.3359.37pathway
Cristae formationR-HSA-89496130422510.750.8753.756.5622pathway
Cross-presentation of soluble exogenous antigens (endosomes)R-HSA-123697826769273.9555960963.9488701695.1019956630.8367346940.5141487110.6754417026.0597713525.8214767141614.959184146.816326523pathway
CS/DS degradationR-HSA-20241014923.1432988083.132971684.8869611910.3291889880.6645944944.1984821275.4783962357.5242pathway
CYP2E1 reactionsR-HSA-211999293279183.5598750433.5310091463.8055958680.6569344020.6666888760.6618116394.7567905545.59870260921061356.258pathway
Cytosolic sulfonation of small moleculesR-HSA-1565843143.0533557293.0533557294.87644108410.3247863250.6623931624.4093153135.43373965995.6666666673pathway
Dectin-1 mediated noncanonical NF-kB signalingR-HSA-56077613590106414.0203561064.0133559295.1823420490.8629519240.4766806670.6698162966.0600937695.8055606741857.480769273.673076926pathway
Defective CFTR causes cystic fibrosisR-HSA-567889528073814.0638350334.0553167945.134393750.8935621850.475051420.6843068036.2852867385.9166570281697.0638316323pathway
Degradation of AXINR-HSA-464125727669914.0812925174.0750613875.2594987770.8482926340.5089275810.6786101076.1949447365.8844982211617.122449148.306122423pathway
Degradation of beta-catenin by the destruction complexR-HSA-195253353105854.0081889954.0017212545.2606591380.857538430.4878838730.6727111525.9817892555.8208040091586.698113206.377358526pathway
Degradation of DVLR-HSA-464125826769244.1661702294.1593041785.1211643870.8541666670.5040268090.6790967386.2821415.9160349951648.5625149.812524pathway
Degradation of GLI1 by the proteasomeR-HSA-5610780328103434.0602650444.0537734955.1293499330.8785106740.4499007430.6642057086.0338534335.7814597371668.942308205.211538525pathway
Degradation of GLI2 by the proteasomeR-HSA-5610783408139713.9718432733.9655851595.100688320.8996106010.446869420.6732400115.957570995.8122144961666.981818261.436363627pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionR-HSA-3134963710853123.5638843213.5468519344.7948014930.7060201330.7073921090.7067061215.389688455.8993355793115.44444413807pathway
Digestion of dietary carbohydrateR-HSA-189085163343.0740582963.066673755.2819389050.6636500750.6503690640.657009574.1235397515.40474989666.3333333358.333333336pathway
Displacement of DNA glycosylase by APEX1R-HSA-11035718565053.9861704573.6613143215.3478382320.5046748830.7936233890.6491491365.204986315.6563843911244.51180.52pathway
Downregulation of ERBB2:ERBB3 signalingR-HSA-1358803593117863.2440830573.2436471865.0538305290.8872214080.3388588550.6130401313.7250850245.1682952281915.7777781375.4444444pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activityR-HSA-21737957232152483.3922775513.2649855555.6697056810.6608644190.5534408760.6071526473.687801695.17844353309.12514057pathway
Downstream TCR signalingR-HSA-2024246466304693.7148283613.7056704045.3751986630.6900841940.5544579120.6222710534.884833845.3867498071592.580247455.987654342pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionR-HSA-4273895575234323.4304320073.3771462095.7618844520.8735555740.4633332510.6684444134.4179428385.59977342210921.8753625.8753pathway
ER-Phagosome pathwayR-HSA-1236974359125053.8581713323.8525962925.1775103950.7626039510.5362704270.6494371895.503487065.6156383681474.644068218.033898331pathway
Fanconi Anemia PathwayR-HSA-6783310127318004.2804962164.0076916435.5297036430.4033338860.7790365710.5911852285.3449388595.368066926803.25768.254pathway
Fatty acidsR-HSA-21193572626823.9786073743.9584555424.3045251240.4208177280.7571174640.5889675964.2300068625.252653098615.3754268pathway
FBXL7 down-regulates AURKA during mitotic entry and in early mitosisR-HSA-8854050307113644.0843323574.0771593625.1512354010.9128448370.4634524090.6881486236.3707291255.9491016061836.021739253.717391322pathway
FCERI mediated NF-kB activationR-HSA-28718375979227423.8436842583.8330019785.1935369480.7700079920.5082635130.6391357525.3028786195.5421331011714.347826416.246376835pathway
Formation of ATP by chemiosmotic couplingR-HSA-1632100422510.750.8753.756.5622pathway
Formation of tubulin folding intermediates by CCT/TriCR-HSA-389960171149343.5799558723.5826095275.3851815770.8843612730.5424593210.7134102975.2174566495.94938727122951.625944.062513pathway
G alpha (z) signalling eventsR-HSA-4185977777203163.7801629293.7364351465.4378320550.6565804920.5934190210.6249997564.6980699895.426719353857.9193548453.112903223pathway
G2/M CheckpointsR-HSA-694811137679834.1178883044.0876779135.1611304810.8541666670.5012274260.6776970466.2385836865.8906097441955.833333403.312522pathway
GABA A receptor activationR-HSA-97744127270373.3705390173.3675972246.0799320960.7362305040.5165838760.626407193.9323341795.2995609392410.6875152.270833312pathway
Galactose catabolismR-HSA-703701454.1897421644.225316555.3263120830.50.8333333330.6666666675.4937565945.8410251669.59.52pathway
Gap junction assemblyR-HSA-190861184160803.5810336453.5835312035.3706958050.8910611370.5430134020.717037275.2503717385.97392634623263956.705882414pathway
GLI3 is processed to GLI3R by the proteasomeR-HSA-5610785408139663.956187583.9498135745.0902566230.9162700570.4477373730.6820037156.0323952525.8654206241697.759259266.185185226pathway
Glucagon signaling in metabolic regulationR-HSA-163359482013483.9242267133.8333770826.3416537010.6770833330.7070661430.6920747385.6037837255.921907158586.125385.512pathway
HCN channelsR-HSA-12960612493.1337721173.1337721175.6153186910.6666666670.6259259260.6462962964.1754229875.35323268119.66666667173pathway
HDACs deacetylate histonesR-HSA-3214815379519573.2059089273.1784724815.6986064730.8264484290.4545434020.6404959163.9001114745.3386090818516.4347832275.4782619pathway
HDL assemblyR-HSA-89638966134183.2911008563.2895028384.7351641910.9365110080.3403103580.6384106834.0861446595.3531048391530.8695.83pathway
Hedgehog ligand biogenesisR-HSA-535834629070104.1164528034.1028040845.131589160.8541666670.4968482820.6755074746.2252702365.8755340971651.229167152.083333324pathway
Hedgehog 'off' stateR-HSA-56107875040189243.7661491373.7287913945.6793135690.7804237160.5374427210.6589332195.0200879285.6482711699383.184211630.631578929pathway
Hedgehog 'on' stateR-HSA-563268429076094.1299248364.1233240575.1853747340.855726210.4615062860.6586162486.0791745855.7674165971602.06157.9826pathway
Heme degradationR-HSA-18948321553.5305433493.4404117093.99371607810.4092329550.7046164775.160639575.87429096564.5382pathway
Hh mutants that don't undergo autocatalytic processing are degraded by ERADR-HSA-536276827769994.1209346334.1123979615.1334659140.8723404260.4861429260.6792416766.295396095.9019227181685.744681154.808510623pathway
HSP90 chaperone cycle for steroid hormone receptors (SHR)R-HSA-33714973334276523.5252422673.4854246565.4268699670.7718671360.5453827310.6586249344.5036131315.56591364714285.466671032.86666725pathway
Hyaluronan uptake and degradationR-HSA-216091671373.1211928483.1054390624.943139680.7142857140.5962712590.6552784863.9955143845.4089208594120.571428575pathway
IkBA variant leads to EDA-IDR-HSA-5603029714981903.1351129453.1192453455.1574916080.7084602670.5596022020.6340312344.060053585.2719125442956.0909091394.4545457pathway
Interaction between L1 and AnkyrinsR-HSA-44509528422403.3764467993.375044745.4947588540.6036152340.7016497650.6526324994.5788944735.476365595289.8695652109.739130411pathway
Interleukin-1 family signalingR-HSA-4466526050172403.7967488213.7802632835.1527953150.8159683540.4938614270.6549148915.4418542975.6316822111615.940299347.611940338pathway
Interleukin-1 processingR-HSA-448706778253663.6765265263.6448100784.6912003030.9172266450.5755358190.7463812326.0114594996.2013837224925.1666672191.3333334pathway
Intraflagellar transportR-HSA-5620924158137883.5787343953.5815649615.4015987850.8767680930.5418313630.7092997285.1801528825.9215763222598.73333929.733333312pathway
Keratan sulfate degradationR-HSA-202285761223.1726559833.1597196964.5712098620.8750.382101190.6285505953.9177506225.2478892965325.63pathway
KinesinsR-HSA-983189354172483.2172847533.2040819664.8229894840.5764466560.6922809760.6343638163.994113255.30152035814182.64286628.642857124pathway
Leukotriene receptorsR-HSA-39190646632073.5058560233.4953518395.9366876190.9962985490.4255823350.7109404425.2120742345.9082216191131.75459.1255pathway
Ligand-gated ion channel transportR-HSA-97529835392323.3328485583.3272402286.0510970660.7240485080.5310421120.627545313.9166113475.2945849191864.382353140.955882422pathway
MAPK6/MAPK4 signalingR-HSA-56871282799188433.6957168583.6739878634.9537735220.8002136620.4970207810.6486172225.1925019395.5560204311344.526316284.763157941pathway
Metabolism of folate and pterinesR-HSA-1967572010963.4206061393.4148100625.3138600620.7990300680.4442139420.6216220053.9255391325.284348745365.4223.25pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membraneR-HSA-190840184160803.5810336453.5835312035.3706958050.8910611370.5430134020.717037275.2503717385.97392634623263956.705882414pathway
Mitochondrial protein importR-HSA-1268020148312.5469109222.2835543294.4929300110.50.8563218390.678160922.9857219985.37004310447.544.754pathway
mTOR signallingR-HSA-165159352108623.3847146663.3272638254.755973850.8285757340.4704379320.6495068334.3790991935.4582837732447.518694pathway
Muscarinic acetylcholine receptorsR-HSA-3906482296109063.1032748163.1019041475.9897981310.8832117310.4276431970.6554274643.9914109695.4039413641658.6428579435pathway
NCAM1 interactionsR-HSA-4190371118613.4347069673.3946369195.6917299530.7178222980.5822550930.6500386964.2898736175.478493628224.897.27pathway
NeddylationR-HSA-8951664105476404.0146639023.9678572725.1120122970.7517674860.536271670.6440195785.6396985975.6316851531377.40678147.355932232pathway
Negative regulation of the PI3K/AKT networkR-HSA-19941811882083.4601143013.459856954.9723449480.873219820.3415328010.6073763113.8331530165.2025468391359.8751040.755pathway
Neurophilin interactions with VEGF and VEGFRR-HSA-194306522118653.3340846973.3345470035.45439950.7584805490.4896653830.6240729664.013365235.2718480063531.82477.43pathway
Neurotransmitter clearanceR-HSA-11231160967063.1906039623.1529349244.9447686570.9670820530.3893033090.6781926814.5433595535.58481919226971828.754pathway
Neurotransmitter receptors and postsynaptic signal transmissionR-HSA-11231427270373.3705390173.3675972246.0799320960.7362305040.5165838760.626407193.9323341795.2995609392410.6875152.270833312pathway
NIK-->noncanonical NF-kB signalingR-HSA-5676590193692884.0462687254.0393527785.1872581290.8596143130.477911370.6687628426.1022216575.8071751861773.78224.4825pathway
Norepinephrine Neurotransmitter Release CycleR-HSA-18143059026323.2312691523.1986876234.8597638060.7762920920.5376906930.6569913924.3615363625.457032333951.8644.44pathway
NOTCH1 Intracellular Domain Regulates TranscriptionR-HSA-212294746371103163.311150493.2687229835.3570937590.706914440.5181462120.6125303263.705163425.1872523398957.43752394.85416721pathway
Orc1 removal from chromatinR-HSA-68949386139593.8683892663.862239475.4030999080.7943727490.5142942890.6543335195.5780246585.6516865461540.741379247.327586225pathway
Organic anion transportR-HSA-561048323933.8389335113.8451042084.7949108380.5958671830.6509166910.6233919374.5701927815.43559075195.8855pathway
Organic cation transportR-HSA-5491278563093.605600853.38798264.76694830.6146639130.6809687470.647816334.54127085.520642481326166.42857147pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaR-HSA-123417652176203.8983989943.8894821245.328961040.7067741870.5912748120.64902455.5373783415.626296331366.644068137.983050827pathway
p75NTR negatively regulates cell cycle via SC1R-HSA-193670211324903.1199788313.1193282375.3109400590.8559060750.4526231730.6542646243.9951865495.4017571028524.2857142335.7857145pathway
Phase 0 - rapid depolarisationR-HSA-557689245871123.3898917633.3840441885.3753415960.7434490460.5617454250.6525972354.4899356835.480612157401189.2521pathway
Phase 2 - plateau phaseR-HSA-55768937611063.1265068613.1208124355.6136733070.6858795940.6146833060.650281454.0424917435.37737862215.230769290.923076928pathway
Physiological factorsR-HSA-55787685515774.166825724.1612929135.8689160680.770541880.67014310.720342496.8032068516.191225173339.16666672725pathway
PKA activationR-HSA-1636156938003.7718578513.7183771025.8428402390.8692572830.5461343050.7076957945.6062980175.975257909573.0526316203.631578913pathway
PKA activation in glucagon signallingR-HSA-164378488045083.8314914243.7545659415.8543767080.8166257040.5809644990.6987951025.5430862465.935797819878.5789474494.105263213pathway
PKA-mediated phosphorylation of key metabolic factorsR-HSA-1633586134183.2911008563.2895028384.7351641910.9365110080.3403103580.6384106834.0861446595.3531048391530.8695.83pathway
Post-chaperonin tubulin folding pathwayR-HSA-389977171149343.5799558723.5826095275.3851815770.8843612730.5424593210.7134102975.2174566495.94938727122951.625944.062513pathway
Prefoldin mediated transfer of substrate to CCT/TriCR-HSA-389957145126423.5773384223.5803711715.4203613090.8680901740.5411136970.7046019355.1375200055.88979237522195.42857913.357142911pathway
Recruitment of NuMA to mitotic centrosomesR-HSA-3803202180289523.3455786153.3320066195.0610258140.7135004960.5513784020.6324394494.0526301595.33145586711374.89744798.256410325pathway
Recycling of bile acids and saltsR-HSA-159418181837563.586029713.4741171814.7377606140.6179628310.6418992520.6299310414.2999664715.394883512578.9333333371.613pathway
Recycling pathway of L1R-HSA-4372392349454943.3797006413.378223144.9390905180.8474746070.4885922760.6680334414.5093058185.58012315616953.54167996.729166725pathway
Regulated proteolysis of p75NTRR-HSA-1936925545267853.4497333233.4198184815.5310693220.693000730.5280192470.6105099893.9923208285.2199776987249.1538462486.9230779pathway
Regulation of activated PAK-2p34 by proteasome mediated degradationR-HSA-21173329175104.086178444.0790186135.1198881450.9129553940.4633573380.6881563666.3733482875.9497685881740.282609169.586956522pathway
Regulation of gene expression in beta cellsR-HSA-21074539273.8872006193.8853201174.1175145730.6666666670.5022374380.5844520523.6971959885.192080556454.33333333103pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)R-HSA-400206753141903.4832439843.3621962775.6880425580.6653041590.5663695570.6158368583.8904194185.2666603822577.722222830.166666710pathway
Regulation of ornithine decarboxylase (ODC)R-HSA-35056227372524.0681811134.0611581055.1378509390.9148224580.4611266920.6879745756.333137645.9425575361692.595745160.10638323pathway
Regulation of PTEN stability and activityR-HSA-8948751564201213.8782778063.871795095.3250430640.8184154720.4936145380.6560150055.5022857995.6661926351507.430769318.230769232pathway
Regulation of pyruvate dehydrogenase (PDH) complexR-HSA-204174160047213.4494051063.4423473855.5494214230.7997535990.4359929750.6178732873.8251481155.2689569481185.3632.16pathway
Regulation of RAS by GAPsR-HSA-565844226969424.0853086754.0783145715.1061850330.8936170210.4787442370.6861806296.3342194945.9363070861684.12766153.425531923pathway
Regulation of RUNX3 expression and activityR-HSA-89418581058124944.0127425333.9894004755.1772129550.8006417330.5271180450.6638798895.8979311525.7634467681682.72271.0424pathway
Regulation of TP53 Activity through AcetylationR-HSA-680475811372317633.4145053153.3436554265.4306461550.7658622180.4746606970.6202614573.9206163235.2732448196255.5882352537.3529417pathway
Repression of WNT target genesR-HSA-4641265144251403.3348807973.3344850145.7263475370.799007420.524417130.6617122754.2812128595.5230420998405.62528.42pathway
Respiratory electron transportR-HSA-61110551063.3929886883.3907419725.1889510080.6666666670.6576023390.6621345034.4365673755.54522624921.518.56pathway
Retinoid cycle disease eventsR-HSA-2453864344023.2977914233.229473195.0483474740.8975552720.5509640660.7242596694.9142945085.927661602220.3333333145.33333333pathway
RHO GTPases activate IQGAPsR-HSA-562646714784191823.5252181443.5064359675.2182755490.7333119240.5757304540.6545211894.5054128225.5385473116624.81358.6419pathway
RIP-mediated NFkB activation via ZBP1R-HSA-1810476718888443.3028102383.2916796884.8540125590.6089074440.640900160.6249038024.0842181775.2669620931967.588235943.058823513pathway
Role of Abl in Robo-Slit signalingR-HSA-428890134110223.0414144913.0411471125.4526344690.9890832180.290677160.6398801893.781445535.2796727572668.61115.62pathway
RUNX1 regulates estrogen receptor mediated transcriptionR-HSA-8931987234152583.8690282113.5696892255.2052143580.3957358660.7985650730.5971504694.1420727765.27067919929281519.83pathway
RUNX1 regulates transcription of genes involved in differentiation of HSCsR-HSA-893923620234162293.9592759973.918554345.2141170090.7494017010.5345017810.6419517415.515493065.5994369372000.483333607.716666729pathway
RUNX1 regulates transcription of genes involved in WNT signalingR-HSA-8939256234152583.8690282113.5696892255.2052143580.3957358660.7985650730.5971504694.1420727765.27067919929281519.83pathway
SCF(Skp2)-mediated degradation of p27/p21R-HSA-187577474215923.6472677193.6417595655.4428522990.6808679960.5672850850.624076544.8207852325.3762661761293.918919298.189189228pathway
SCF-beta-TrCP mediated degradation of Emi1R-HSA-17411326769174.1155309334.1082071455.1411194570.9111111110.470961930.691036526.4546624165.978753781758.288889159.644444421pathway
Separation of Sister ChromatidsR-HSA-24678132110288383.7961779173.7895668695.3803338370.7828115070.5434915790.6631515435.4303941325.6864029236359.315789407.210526348pathway
Signaling by BMPR-HSA-201451916283.4441200283.4447027325.1999967020.9954887220.2788488270.6371687744.4178498285.395831839135.7142857102.71428577pathway
Stimuli-sensing channelsR-HSA-267235111136613.2040741223.1590186464.8746143810.6695515170.6232959910.6464237544.1747453285.3775164264.8947368198.526315817pathway
Synthesis of bile acids and bile saltsR-HSA-19210590719373.8375633723.6017605694.6671397830.4991542850.6934749330.5963146094.0359822055.254618516878.66666674744pathway
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)R-HSA-2142670208065453.3420340033.308352515.0544996450.6127815950.6254699830.6191257893.9283468625.2415165941576.751078.1258pathway
Tachykinin receptors bind tachykininsR-HSA-38009589546043.6036141463.6035605066.2048800730.6608323640.5593726020.6101024834.1195438795.2685546042717.66666718333pathway
The NLRP1 inflammasomeR-HSA-8444553116143.4447697453.2551649035.8093884760.5456381170.8231607290.6843994234.4146317375.7109194514.25411.253pathway
The role of GTSE1 in G2/M progression after G2 checkpointR-HSA-885227613499346853.8038017213.7740339035.258089620.8034938740.5203951570.6619445165.3827239335.6808973476384.8375602.343pathway
TNFR1-mediated ceramide productionR-HSA-562697853523.3801753123.3341822934.9073372690.3986111110.8146376810.6066243963.809793455.17088774544353pathway
TNFR2 non-canonical NF-kB pathwayR-HSA-566854132072944.1542205364.14522925.1540123250.7960737180.5402333080.6681535136.073643485.8390969331532.826923146.423076927pathway
TRAF6 mediated NF-kB activationR-HSA-933542720388843.1961407373.1850101865.0048521480.6677309730.5967127190.6322218464.0987358435.2801925541965.352941946.294117612pathway
Translocation of GLUT4 to the plasma membraneR-HSA-1445148435243583.4920884853.4851546285.0811427320.5202954680.6901220460.6052087573.8719774055.1987545448876.847826538.978260928pathway
Transport of bile salts and organic acids, metal ions and amine compoundsR-HSA-425366117703.7176435213.5649994424.7908192370.6666666670.7123499310.6895082995.2897361295.83593659562.333333333pathway
Transport of organic anionsR-HSA-87951894815183.8961522593.8677557655.3630977890.8725497920.6075447070.740047256.3387254586.232365751343.22222222749pathway
Triglyceride catabolismR-HSA-16356012340183.3697853073.3020668515.4655114090.6971433730.5520839780.6246136753.9470270355.287352937531.0625258.812513pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-69601614151704.0189675444.0049265815.0975832290.8842795390.4662521740.6752658576.0850934675.8414282261796.6315.6825pathway
Ubiquitin-dependent degradation of Cyclin D1R-HSA-69229313183313.8572549113.8520241445.234403670.7559129440.5351748130.6455438785.381687265.5893774941472.84127295.936507923pathway
Ub-specific processing proteasesR-HSA-568988021610187863.8361693173.7729231925.3685353440.5501260220.6564950460.6033105344.6770220445.3007933341291.383838408.04040457pathway
UCH proteinasesR-HSA-568960382775943.9967534423.9878119115.093702250.8574048080.4902129690.6738088896.0026989535.8243104051527.87037155.944444429pathway
Uptake and function of diphtheria toxinR-HSA-533641522420153.8530911953.7196743015.0768200930.6273649990.5527095440.5900372714.061820025.217945541632.75279.8755pathway
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-432040488353423.7959521283.7228750755.8724677540.8257944190.5672333080.6965138635.4713651085.908743132898.5511.2514pathway
Vif-mediated degradation of APOBEC3GR-HSA-18058526769174.1155309334.1082071455.1411194570.9111111110.470961930.691036526.4546624165.978753781758.288889159.644444421pathway
Vitamin D (calciferol) metabolismR-HSA-19679121003.3508096323.3494718684.6649832870.750.6949771690.7224885845.0363972615.93352710739.7525.54pathway
VitaminsR-HSA-2119161963.1861993863.185951135.9521864980.6666666670.6155251140.641095894.0028341635.33603906549.3333333332.333333333pathway
VLDL assemblyR-HSA-8866423131293.7517410813.6671027687.0237955660.2330097090.9498381880.5914239483.8352122125.19340668252.3333333347.333333333pathway
Vpu mediated degradation of CD4R-HSA-18053426769284.1165959794.1094314055.1359627820.8913043480.4824627570.6868835536.38224355.9514223431720.586957156.413043522pathway
XenobioticsR-HSA-2119813964128463.4053517953.3650141694.3612081980.5978410930.6952328470.646536974.3046971095.4453637291355.736842884.736842117pathway