P543 Repurposing

Repurposing Drugs for Enhancement of P53 Expression

About 3k among the 1.5M annotated molecules in the ChEMBL DB are prescription drugs. For some of them, there is a record of activity on P53 expression experiments, but for the most that don’t have any, there is a predicted score. The variable AvgPredIdex contains the actual score if it exists, but the predicted one if it doesn’t. It results from a combination of binomial and regression decision trees and random forests outcome. These scores have a -log(molar potency) scale.

Applying the dashboard based selection methods described in the prediction of P53 activity section upon prescription drugs we have created unique drug target pairs with average scores per pair: the already described AvgPredIdex and the chemblActivityScoreC which shows the effect that the molecule average score for each particular target.

The 2 graphs below shows AvgPredIdex vs chemblActivityScoreC . Marked dots are displayed on the right side showing the targets where the drugs have an activity record  and the value, in bars of their potency at target compared to the potency enhancing P53 expression.

 

Most potent drug-target pairs. data from actual values.

 

Most potent drug-target pairs. data from predicted values.

 

 

Most potent drugs for repurposing

molNamekindOfValuep53ActivityScoreActualp53ActiveActualproteinNameCorganismCavgPredIndexAvgPrediction80RFRegressionAvgChemblActivityScoreCcountRatioRpartcountRatioRFcountRatioAvgRpartRFCountChemblActivityScoreCdrugIndicationCdrugMoAseccentricityProteinclosnesscentralityProteinharmonicclosnesscentralityProteinbetweenesscentralityProteinmodularity_classProteinpageranksProteindegreeProteinweighted degreeProteineccentricityMolNameclosnesscentralityMolNameharmonicclosnesscentralityMolNamebetweenesscentralityMolNamemodularity_classMolNamepageranksMolNamedegreeMolNameweighted degreeMolName
DIAZEPAMactual6.7070797YNotRecordedHomo sapiens8.0690265676.70707977.5427448870.8750.8750.87524ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator70.2590650280.2755019428450.90816830.001274989111170.2626861140.29123495624208.2975330.0027530172020
DIAZEPAMactual6.7070797YNotRecordedHomo sapiens8.4856932336.70707977.2540675980.87510.937524ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator70.2590650280.2755019428450.90816830.001274989111170.2626861140.29123495624208.2975330.0027530172020
DIAZEPAMactual6.7070797YGABA-A receptor; anion channelBos taurus7.4737884726.70707977.840.57142857110.78571428642ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator80.2560722750.2732655828687.90209300.001208292111170.2626861140.29123495624208.2975330.0027530172020
DIAZEPAMactual6.7070797YGABA receptor gamma-1 subunitRattus norvegicus5.5690265675.5303097758.3100.51ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator80.2519673560.266384368411.73757930.0002508492270.2626861140.29123495624208.2975330.0027530172020
DIAZEPAMactual6.7070797YGABA receptor alpha-1 subunitHomo sapiens8.90235996.70707977.441111ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator80.2080625750.22064915030.0002007231170.2626861140.29123495624208.2975330.0027530172020
DIAZEPAMactual6.7070797YGABA A receptor alpha-3/beta-2/gamma-2Homo sapiens8.90235996.70707977.9251116ANXIETY, EPILEPSY, PAIN, POST-TRAUMATIC STRESS DISORDER, SEIZURESGABA-A receptor; anion channel positive allosteric modulator80.2080625750.22064915030.0002007231170.2626861140.29123495624208.2975330.0027530172020
CLOZAPINEpredictedAlpha-1d adrenergic receptorHomo sapiens7.33333333327.6151112BIPOLAR DISORDER, PSYCHOSIS, SCHIZOPHRENIADopamine D2 receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist60.2810468140.3042799312336.53166200.001223953222270.2883589060.3198876319716.58030300.0014730772424
ONDANSETRONpredictedSerotonin 3 receptor (5HT3)Mus musculus7.5729221342.7187664027.921112ALCOHOL DEPENDENCE, BRAIN DISEASE, BREAST CARCINOMA, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING, COCAINE DEPENDENCE, DYSPNEA, FISH-EYE DISEASE, IRRITABLE BOWEL SYNDROME, NAUSEA, NAUSEA AND VOMITING, NEOPLASM, OBSESSIVE-COMPULSIVE DISORDER, PAIN, POST OPERATIVE NAUSEA AND VOMITING, RADIATION-INDUCED NAUSEA AND VOMITING, SCHIZOPHRENIASerotonin 3a (5-HT3a) receptor antagonist80.2027439020.21423269717.8266257400.0002504672270.2288853590.2443402462435.86336900.00058092155
RISPERIDONEpredictedAlpha-1a adrenergic receptorRattus norvegicus7.2961092864.3883278578.837510.750.8754ANOREXIA NERVOSA, ASPERGER SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER, AUTISM, BIPOLAR DISORDER, COCAINE DEPENDENCE, DIABETES MELLITUS, FISH-EYE DISEASE, INJURY, METAMPHETAMINE DEPENDENCE, MOVEMENT DISORDER, PSYCHOSIS, SCHIZOPHRENIA, UNIPOLAR DEPRESSIONDopamine D2 receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.2773500160.2995758631543.58317800.001147715212170.2599218280.283919965522.647968200.0008499141515
RISPERIDONEpredictedAlpha-2c adrenergic receptorHomo sapiens7.1621169143.9863507438.342510.750.8754ANOREXIA NERVOSA, ASPERGER SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER, AUTISM, BIPOLAR DISORDER, COCAINE DEPENDENCE, DIABETES MELLITUS, FISH-EYE DISEASE, INJURY, METAMPHETAMINE DEPENDENCE, MOVEMENT DISORDER, PSYCHOSIS, SCHIZOPHRENIA, UNIPOLAR DEPRESSIONDopamine D2 receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.2793214860.3025448242596.31627100.001323976242470.2599218280.283919965522.647968200.0008499141515
RISPERIDONEpredictedAlpha-1b adrenergic receptorRattus norvegicus8.004179524.012538568.841112ANOREXIA NERVOSA, ASPERGER SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER, AUTISM, BIPOLAR DISORDER, COCAINE DEPENDENCE, DIABETES MELLITUS, FISH-EYE DISEASE, INJURY, METAMPHETAMINE DEPENDENCE, MOVEMENT DISORDER, PSYCHOSIS, SCHIZOPHRENIA, UNIPOLAR DEPRESSIONDopamine D2 receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.2797734630.303171392167.21549500.0013047242470.2599218280.283919965522.647968200.0008499141515
RISPERIDONEpredictedAlpha-1d adrenergic receptorHomo sapiens8.0908891144.2726673438.1551112ANOREXIA NERVOSA, ASPERGER SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER, AUTISM, BIPOLAR DISORDER, COCAINE DEPENDENCE, DIABETES MELLITUS, FISH-EYE DISEASE, INJURY, METAMPHETAMINE DEPENDENCE, MOVEMENT DISORDER, PSYCHOSIS, SCHIZOPHRENIA, UNIPOLAR DEPRESSIONDopamine D2 receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.2810468140.3042799312336.53166200.001223953222270.2599218280.283919965522.647968200.0008499141515
PACLITAXELactual8.075720714YPrelamin-A/CHomo sapiens6.0252402388.0757207147.498010.55ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.3005910990.33649508423750.1528740.003255772464650.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YIntegrin alpha-V/beta-3Homo sapiens9.3585735718.0757207147.471112ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.2510891660.261509543040.000149621150.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YVitamin D receptorHomo sapiens9.3585735718.0757207147.7495799981111ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.2795021020.3023327554501.20797840.001198924161650.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YTubulin beta-3 chainHomo sapiens9.3585735718.0757207148.0751112ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.2510891660.261509543040.000149621150.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YATPase family AAA domain-containing protein 5Homo sapiens7.6919069058.0757207147.6368279610.510.752ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.2856906810.3124060157238.53422840.001760396262650.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YAndrogen ReceptorHomo sapiens9.3585735718.0757207147.5361377851112ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.3808370040.4451417265199.967340.01213448314714750.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens6.0252402388.0757207147.436402232010.52ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.281963470.3105359557654.13081240.002205777323250.3352074450.36281087330411.369540.0025583813333
PACLITAXELactual8.075720714YRetinoid X receptor alphaHomo sapiens9.3585735718.0757207148.3010299961111ADENOCARCINOMA, BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CERVICAL CARCINOMA, COLORECTAL ADENOCARCINOMA, CORONARY RESTENOSIS, CUTANEOUS MELANOMA, ENDOMETRIAL NEOPLASM, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, GLIOBLASTOMA MULTIFORME, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HEPATOCELLULAR CARCINOMA, KAPOSI'S SARCOMA, LUNG CARCINOMA, MALE BREAST CARCINOMA, MELANOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PERIPHERAL VASCULAR DISEASE, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, THYROID CARCINOMA, UPPER AERODIGESTIVE TRACT NEOPLASM, UTERINE NEOPLASMTubulin inhibitor60.2834426230.3097262396386.9856940.001646278242450.3352074450.36281087330411.369540.0025583813333
COLCHICINEactual6.925183559YPeroxisome proliferator-activated receptor gammaHomo sapiens8.9750611866.6789243817.5834310071113ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.27842190.3014362834650.2521440.001331689181850.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YGemininHomo sapiens7.308394526.0141608737.4130986030.510.758ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.3585649110.40891652290556.9183440.005157074757550.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YAndrogen ReceptorHomo sapiens8.9750611866.7505456947.60408839611110ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.3808370040.4451417265199.967340.01213448314714750.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YRetinoid X receptor alphaHomo sapiens8.9750611866.6789243817.5252706011114ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.2834426230.3097262396386.9856940.001646278242450.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YInterleukin-8Homo sapiens8.9750611866.9251835597.3000221691112ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.262845850.278532871271.128605540.0004654766650.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YBile acid receptor FXRHomo sapiens8.9750611866.6789243817.4669338231113ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.284655910.31068054811397.4094740.001729474232350.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YThyroid hormone receptor beta-1Homo sapiens8.9750611866.3916220078.1178745621112ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.2787810380.30386543312097.9095140.001979349252550.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YChromobox protein homolog 1Homo sapiens5.6417278533.6417278538.420216403010.51ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.2710881150.289059186909.044074840.0005497547750.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559Y6-phospho-1-fructokinaseTrypanosoma brucei5.6417278536.0017116427.42136079010.51ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.271599120.289695392837.74848640.000685623101050.3379593430.36705224619703.8941740.0025692983838
COLCHICINEactual6.925183559YIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens5.6417278535.3347597028.13667714010.51ACUTE CORONARY SYNDROME, APHTHOUS ULCER, ATRIAL FIBRILLATION, BEHCET'S SYNDROME, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CORONARY ARTERY DISEASE, DIABETIC NEPHROPATHY, FAMILIAL MEDITERRANEAN FEVER, GOUT, HEPATOCELLULAR CARCINOMA, MYOCARDIAL INFARCTION, OSTEOARTHRITIS, PROSTATE CARCINOMA, VASCULAR DISEASETubulin inhibitor60.281963470.3105359557654.13081240.002205777323250.3379593430.36705224619703.8941740.0025692983838
TRIFLUPERIDOLpredictedSigma opioid receptorHomo sapiens7.7625110393.2875331169.081111PSYCHOSISunknown70.272798990.2936200396238.02727100.001227309181880.2148893860.2245861911761.12023740.00040423933
TRIFLUPERIDOLpredictedC-8 sterol isomeraseSaccharomyces cerevisiae S288c7.5437554872.6312664629.821111PSYCHOSISunknown80.2420212770.253033683566.499706940.000332133380.2148893860.2245861911761.12023740.00040423933
TRIFLUPERIDOLpredictedSigma opioid receptorRattus norvegicus7.7625110393.2875331169.11111PSYCHOSISunknown70.272798990.2936200396238.02727100.001227309181880.2148893860.2245861911761.12023740.00040423933
LORAZEPAMpredictedAndrogen ReceptorHomo sapiens7.5791666172.737499858.5686362361111ALCOHOL DEPENDENCE, ALCOHOL WITHDRAWAL, ALZHEIMERS DISEASE, ANXIETY, ANXIETY DISORDER, DEMENTIA, EPILEPSY, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSIONGABA-A receptor; anion channel positive allosteric modulator60.3808370040.4451417265199.967340.01213448314714770.2758455650.297121926040.00015385511
SAQUINAVIRpredictedHuman immunodeficiency virus type 1 proteaseHuman immunodeficiency virus 18.0432979254.1298937768.81522931711153HIV INFECTIONHuman immunodeficiency virus type 1 protease inhibitor70.2511621150.264344928264.430431130.0005238176670.2856906810.3111735383834.97490100.0009493571313
ROPINIROLEpredictedDopamine D4 receptorHomo sapiens7.33333333328.111111PARKINSON'S DISEASE, RESTLESS LEGS SYNDROMEunknown60.2786911670.2997493731729.43779200.000998692171770.2393410850.25618028614.2915304300.00028010244
MEROPENEMpredictedPeroxisome proliferator-activated receptor deltaHomo sapiens7.33333333327.8761483591111BRONCHIECTASIS, INFECTION, INFECTIOUS MENINGITIS, PNEUMONIA, SEPSIS, TUBERCULOSIS, URINARY TRACT INFECTIONBacterial penicillin-binding protein inhibitor60.34901090.39550800185678.0111640.005261171686870.2587548640.275537745040.00014945511
BETAMETHASONEpredictedAndrogen ReceptorHomo sapiens8.8143652486.4430957438.0778036751117ABNORMALITY OF GASTROINTESTINAL VASCULATURE, ADENOMA, ALOPECIA AREATA, ATOPIC ECZEMA, DIABETIC RETINOPATHY, EYE INFLAMMATION, GLAUCOMA, NASAL OBSTRUCTION, NEWBORN RESPIRATORY DISTRESS SYNDROME, OBSTRUCTIVE LUNG DISEASE, OSTEOARTHRITIS, PAIN, PREMATURE BIRTH, PSORIASIS, TENOSYNOVITISGlucocorticoid receptor agonist60.3808370040.4451417265199.967340.01213448314714770.3158567770.3378074311595.61443740.00053963277
BETAMETHASONEpredictedGlucocorticoid receptorHomo sapiens8.8692182826.6076548457.8700407651113ABNORMALITY OF GASTROINTESTINAL VASCULATURE, ADENOMA, ALOPECIA AREATA, ATOPIC ECZEMA, DIABETIC RETINOPATHY, EYE INFLAMMATION, GLAUCOMA, NASAL OBSTRUCTION, NEWBORN RESPIRATORY DISTRESS SYNDROME, OBSTRUCTIVE LUNG DISEASE, OSTEOARTHRITIS, PAIN, PREMATURE BIRTH, PSORIASIS, TENOSYNOVITISGlucocorticoid receptor agonist70.2818715360.3093847268327.82501240.002151998303070.3158567770.3378074311595.61443740.00053963277
DICLOFENACpredictedCyclooxygenase-1Bos taurus8.0524558574.157367578.521111ACTINIC KERATOSIS, ANKYLOSING SPONDYLITIS, ARTHRALGIA, BASAL CELL CARCINOMA, CYSTOID MACULAR EDEMA, DIABETIC RETINOPATHY, EYE INFLAMMATION, GLAUCOMA, INFERTILITY, MYALGIA, OSTEOARTHRITIS, OSTEOARTHRITIS, KNEE, PAIN, PANCREATITIS, PULMONARY EMBOLISM, RHEUMATIC DISEASE, RHEUMATOID ARTHRITIS, UNIPOLAR DEPRESSION, URINARY TRACT INFECTIONCyclooxygenase inhibitor70.2753184710.2972293378980.26588340.001619472202070.2612571770.2857790081772.56338740.00070581688
DICLOFENACpredictedInterleukin-8Homo sapiens8.0545805774.163741738.11111ACTINIC KERATOSIS, ANKYLOSING SPONDYLITIS, ARTHRALGIA, BASAL CELL CARCINOMA, CYSTOID MACULAR EDEMA, DIABETIC RETINOPATHY, EYE INFLAMMATION, GLAUCOMA, INFERTILITY, MYALGIA, OSTEOARTHRITIS, OSTEOARTHRITIS, KNEE, PAIN, PANCREATITIS, PULMONARY EMBOLISM, RHEUMATIC DISEASE, RHEUMATOID ARTHRITIS, UNIPOLAR DEPRESSION, URINARY TRACT INFECTIONCyclooxygenase inhibitor60.262845850.278532871271.128605540.0004654766670.2612571770.2857790081772.56338740.00070581688
DARUSENTANpredictedEndothelin receptor ET-ARattus norvegicus7.7958388933.387516688.221111HYPERTENSIONEndothelin receptor ET-A antagonist, Endothelin receptor ET-B antagonist80.2024116130.2131923213455110.0006790543390.168354430.1743672370110.00027609411
DARUSENTANpredictedEndothelin receptor ET-AHomo sapiens7.7917895673.3753687029.11111HYPERTENSIONEndothelin receptor ET-A antagonist, Endothelin receptor ET-B antagonist80.2024116130.2131923213455110.0006790543390.168354430.1743672370110.00027609411
CARVEDILOLpredictedBeta-1 adrenergic receptorHomo sapiens7.7583443313.2750329929.871112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist70.2735759490.2946129062721.28015800.00109185171770.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedBeta-2 adrenergic receptorHomo sapiens7.7583443313.2750329929.71112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist70.2622876210.2790162221113.25860300.0006239339970.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedBeta-3 adrenergic receptorHomo sapiens7.7583443313.2750329928.4451112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.2748807630.2938885682259.08210600.000800035121270.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedAlpha-1a adrenergic receptorRattus norvegicus7.7426151943.2278455838.3051112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.2773500160.2995758631543.58317800.001147715212170.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedSerotonin 2b (5-HT2b) receptorHomo sapiens7.9979331313.9937993947.731112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.3114193080.34829381118639.7258800.00222842383870.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedAlpha-1b adrenergic receptorRattus norvegicus7.7426151943.2278455838.581112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.2797734630.303171392167.21549500.0013047242470.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedAlpha-2c adrenergic receptorHomo sapiens7.9979331313.9937993947.471112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.2793214860.3025448242596.31627100.001323976242470.2720264320.3033338843462.26180600.0015335052727
CARVEDILOLpredictedAlpha-1d adrenergic receptorHomo sapiens7.7583443313.2750329928.8951112ALZHEIMERS DISEASE, ANGINA PECTORIS, ATRIAL FIBRILLATION, BREAST CARCINOMA, CANCER, CARDIOVASCULAR DISEASE, CIRRHOSIS OF LIVER, COCAINE DEPENDENCE, CONGESTIVE HEART FAILURE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, DUCHENNE MUSCULAR DYSTROPHY, EPILEPSY, HEART FAILURE, HEMORRHAGE, HYPERTENSION, MYOCARDIAL INFARCTION, PORTAL HYPERTENSION, POST-TRAUMATIC STRESS DISORDER, PULMONARY HYPERTENSIONAdrenergic receptor alpha-1 antagonist, Adrenergic receptor beta antagonist60.2810468140.3042799312336.53166200.001223953222270.2720264320.3033338843462.26180600.0015335052727
GLUCAGONpredictedAdenylate cyclaseRattus norvegicus8.6685525026.0056575068.18666666711124COLORECTAL ADENOCARCINOMA, DIABETES MELLITUS, HEART FAILURE, HYPOGLYCEMIA, PRIMARY SHORT BOWEL SYNDROME, TYPE I DIABETES MELLITUS, TYPE II DIABETES MELLITUSGlucagon receptor agonist70.2524824770.266234267345400.0003363672280.201656170.208747143172800.00046621622
CLAVULANIC ACIDpredictedBeta-lactamaseKlebsiella oxytoca8.4381117625.3143352857.7403626891111COCAINE DEPENDENCEunknown70.2310261890.2417554885166100.0003640982280.1879347830.1957400378630.5100.00154746477
DEXMEDETOMIDINEpredictedAdrenergic receptor alpha-1Rattus norvegicus7.7500109383.2500328138.31113ACUTE KIDNEY INJURY, AGITATION, ALCOHOL DRINKING, ANXIETY, CANCER, CEREBRAL PALSY, COLORECTAL ADENOCARCINOMA, CONGENITAL HEART DISEASE, CORONARY ARTERY DISEASE, COUGH, DIABETES MELLITUS, DIGESTIVE SYSTEM DISEASE, GASTRIC CARCINOMA, HEART DISEASE, HEMORRHAGE, HYPERTENSION, INJURY, KIDNEY DISEASE, LUNG CARCINOMA, MENTAL OR BEHAVIOURAL DISORDER, NEOPLASM, OBESITY, OBSTRUCTIVE SLEEP APNEA, OTITIS MEDIA, PAIN, PANCREATITIS, PARKINSON'S DISEASE, POST OPERATIVE NAUSEA AND VOMITING, POST-OPERATIVE SIGN OR SYMPTOM, PULMONARY HYPERTENSION, RESPIRATORY FAILURE, SCOLIOSIS, SEPSIS, SEPTIC SHOCK, SUBARACHNOID HEMORRHAGE, TINNITUS, TONSILLITISunknown60.2745315970.2959899756061.93235900.001260283202070.2262496730.24045140315.5731581600.00028504844
DEXMEDETOMIDINEpredictedAdrenergic receptor alpha-2Rattus norvegicus7.5437554872.63126646210.821113ACUTE KIDNEY INJURY, AGITATION, ALCOHOL DRINKING, ANXIETY, CANCER, CEREBRAL PALSY, COLORECTAL ADENOCARCINOMA, CONGENITAL HEART DISEASE, CORONARY ARTERY DISEASE, COUGH, DIABETES MELLITUS, DIGESTIVE SYSTEM DISEASE, GASTRIC CARCINOMA, HEART DISEASE, HEMORRHAGE, HYPERTENSION, INJURY, KIDNEY DISEASE, LUNG CARCINOMA, MENTAL OR BEHAVIOURAL DISORDER, NEOPLASM, OBESITY, OBSTRUCTIVE SLEEP APNEA, OTITIS MEDIA, PAIN, PANCREATITIS, PARKINSON'S DISEASE, POST OPERATIVE NAUSEA AND VOMITING, POST-OPERATIVE SIGN OR SYMPTOM, PULMONARY HYPERTENSION, RESPIRATORY FAILURE, SCOLIOSIS, SEPSIS, SEPTIC SHOCK, SUBARACHNOID HEMORRHAGE, TINNITUS, TONSILLITISunknown60.271599120.2908810491565.06193100.000906941151570.2262496730.24045140315.5731581600.00028504844
METHOTREXATEactual6.919470153YDihydrofolate reductaseHomo sapiens8.9731567186.9194701538.10953383111167ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseMus musculus8.9731567186.9194701538.85926674511127ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseRattus norvegicus8.9731567186.9194701538.72166666711112ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YPrelamin-A/CHomo sapiens5.6398233846.9194701537.55010.53ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor60.3005910990.33649508423750.1528740.003255772464660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseLactobacillus casei8.9731567186.9194701537.91611955911137ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductasePneumocystis carinii8.9731567186.9194701538.79474250111112ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseEscherichia coli8.9731567186.8737429087.77998273411126ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YIsocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens5.6398233846.9194701538.283996656010.51ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor60.281963470.3105359557654.13081240.002205777323260.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseLeishmania major8.9731567186.9194701539.891111ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseEnterococcus faecium8.9731567186.9194701538.851111ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
METHOTREXATEactual6.919470153YDihydrofolate reductaseGallus gallus8.9731567186.9194701537.3851112ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, ALOPECIA AREATA, ASTHMA, ATOPIC ECZEMA, CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC CHILDHOOD ARTHRITIS, CORONARY ARTERY DISEASE, CROHN'S DISEASE, HEAD AND NECK SQUAMOUS CELL CARCINOMA, HISTIOCYTOSIS, HYDATIDIFORM MOLE, IMMUNE SYSTEM DISEASE, LYMPHOMA, MALARIA, MYASTHENIA GRAVIS, MYCOSIS FUNGOIDES, MYOCARDIAL INFARCTION, NEOPLASM, OSTEOARTHRITIS, OSTEOSARCOMA, PAIN, POSTERIOR UVEITIS, PSORIASIS, PSORIATIC ARTHRITIS, RETINOPATHY, RHEUMATOID ARTHRITIS, SYSTEMIC SCLERODERMA, ULCERATIVE COLITIS, UPPER AERODIGESTIVE TRACT NEOPLASM, URTICARIADihydrofolate reductase inhibitor70.2524824770.2653956323369.24451740.0006430716660.308419550.33446115314777.5742740.0018089922323
EPROSARTANpredictedType-1B angiotensin II receptorRattus norvegicus7.5480340182.64410205391111CARDIOVASCULAR DISEASE, HYPERTENSIONunknown80.2347908750.2471171061168.581636110.0004676434480.1982798170.20594962727.11194876110.00046710644
EPROSARTANpredictedAngiotensin II type 2 (AT-2) receptorRattus norvegicus7.8126229793.43786893691111CARDIOVASCULAR DISEASE, HYPERTENSIONunknown80.2347271250.246731527481.6204227110.0003491333380.1982798170.20594962727.11194876110.00046710644
EPROSARTANpredictedAngiotensin II receptorHomo sapiens8.2084104564.6252313678.3215421011116CARDIOVASCULAR DISEASE, HYPERTENSIONunknown80.2323924730.2461827653858.195318110.0010139549980.1982798170.20594962727.11194876110.00046710644
LOXAPINEpredictedDopamine D3 receptorHomo sapiens7.33333333327.661111ASTHMA, BIPOLAR DISORDER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, NICOTINE DEPENDENCE, PSYCHOSIS, SCHIZOPHRENIAD2-like dopamine receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.289614740.3209465979204.65765900.002356341424270.2423605270.2605855353.2421614200.00033348855
LOXAPINEpredictedDopamine D2 receptorRattus norvegicus7.33333333327.681111ASTHMA, BIPOLAR DISORDER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, NICOTINE DEPENDENCE, PSYCHOSIS, SCHIZOPHRENIAD2-like dopamine receptor antagonist, Serotonin 2a (5-HT2a) receptor antagonist, Serotonin 2c (5-HT2c) receptor antagonist60.28559630.3141218439635.28533700.002095645353570.2423605270.2605855353.2421614200.00033348855
BOSUTINIBpredictedTyrosine-protein kinase ABLHomo sapiens7.6832670933.0498012798.981114BREAST NEOPLASM, CHRONIC MYELOGENOUS LEUKEMIA, GLIOBLASTOMA MULTIFORME, LEUKEMIA, NEOPLASMTyrosine-protein kinase ABL inhibitor, Tyrosine-protein kinase HCK inhibitor, Tyrosine-protein kinase Lyn inhibitor, Tyrosine-protein kinase SRC inhibitor60.2991349480.3355793333196.709319350.000616628141470.2681451610.3138753483761.167350.0035593129393
MYCOPHENOLIC ACIDactual7.144480844YInosine-5'-monophosphate dehydrogenase 2Homo sapiens8.2905845247.1444808447.7309090910.77272727310.88636363622ACUTE GRAFT VS. HOST DISEASE, CHRONIC KIDNEY DISEASE, IMMUNE SYSTEM DISEASE, INFECTION, INJURYInosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor70.2370441460.247689278040.0001508981160.3106360040.3360709476460.97011540.0011064461414
MYCOPHENOLIC ACIDactual7.144480844YInosine-5'-monophosphate dehydrogenase 1Homo sapiens9.0481602817.1444808447.47363636411111ACUTE GRAFT VS. HOST DISEASE, CHRONIC KIDNEY DISEASE, IMMUNE SYSTEM DISEASE, INFECTION, INJURYInosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor70.2370441460.247689278040.0001508981160.3106360040.3360709476460.97011540.0011064461414
VANCOMYCINpredictedNorepinephrine transporterRattus norvegicus8.5403174045.6209522117.81111CELLULITIS, CONSTIPATION, CORONARY ARTERY DISEASE, CYSTIC FIBROSIS, ENDOCARDITIS, INFECTION, PNEUMONIA, SCLEROSING CHOLANGITIS, SKIN DISEASEunknown60.2917651030.32305764415803.7068800.002617056424270.2360731840.2543542921996.17875100.0005045966
KETOCONAZOLEpredictedGonadotropin-releasing hormone receptorRattus norvegicus7.8023670233.4071010687.721114ASTHMA, CANCER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, INFECTION, LYMPHOMA, MELANOMA, MULTIPLE SCLEROSIS, NEOPLASM, PREMATURE BIRTH, PROSTATE CARCINOMA, RETINOPATHY, SEBORRHEIC DERMATITISCytochrome P450 51 inhibitor80.2262496730.240171176906170.0010404285570.2919621750.32190228320186.1976800.0019140312323
DOXORUBICINpredictedSerine/threonine-protein kinase Aurora-AHomo sapiens8.3901036995.1703110977.41111ACUTE LYMPHOBLASTIC LEUKEMIA, BREAST CARCINOMA, CANCER, CARCINOMA, CUTANEOUS T-CELL LYMPHOMA, ENDOMETRIAL NEOPLASM, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LYMPHOID LEUKEMIA, LYMPHOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, OSTEOSARCOMA, OVARIAN CARCINOMA, OVARIAN NEOPLASM, PRIMARY SYSTEMIC AMYLOIDOSIS, PROSTATE CARCINOMA, SARCOMA, SMALL CELL LUNG CARCINOMA, THYROID CARCINOMAunknown60.29029550.3265760563354.359991350.0005329349970.2735759490.2946005127334.63259900.0011000451313
TEZOSENTANpredictedEndothelin receptor ET-AHomo sapiens7.9589254393.8767763177.641111HEART FAILURE, PULMONARY HYPERTENSIONEndothelin receptor ET-A antagonist, Endothelin receptor ET-B antagonist80.2024116130.2131923213455110.0006790543390.168354430.1743672370110.00027609411
CLOTHIAPINEpredictedDopamine D2 receptorHomo sapiens7.33333333329.311111PSYCHOSISunknown60.28559630.3141218439635.28533700.002095645353570.223442750.2359497659.22578038400.00024624533
LOSARTAN POTASSIUMpredictedAngiotensin II receptorHomo sapiens8.1280410944.3841232818.521112ATRIAL FIBRILLATION, EOSINOPHILIC ESOPHAGITIS, HYPERTENSION, MARFAN SYNDROME, PROTEINURIAType-1 angiotensin II receptor antagonist80.2323924730.2461827653858.195318110.0010139549980.1981889040.2051784688.079277503110.00027881522
TASOSARTANpredictedAngiotensin II receptorHomo sapiens7.6183399732.8550199188.41112CARDIOVASCULAR DISEASEunknown80.2323924730.2461827653858.195318110.0010139549980.1981889040.2051784685.506447179110.00026883822
VALSARTANpredictedType-1A angiotensin II receptorRattus norvegicus7.8126229793.4378689368.471111ATRIAL FIBRILLATION, CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, CONGESTIVE HEART FAILURE, CORONARY ARTERY DISEASE, DIABETES MELLITUS, DILATED CARDIOMYOPATHY, HEART FAILURE, HYPERTENSION, HYPERTROPHIC CARDIOMYOPATHY, IGA GLOMERULONEPHRITIS, METABOLIC SYNDROME, MYOCARDIAL INFARCTION, NON-HODGKINS LYMPHOMA, OBSTRUCTIVE SLEEP APNEA, PROTEINURIA, TYPE II DIABETES MELLITUS, VITAMIN D DEFICIENCYType-1 angiotensin II receptor antagonist70.244900850.2567338682159.703983110.000468014480.1967455620.2026515460110.00018314311
PATUPILONEpredictedNuclear receptor subfamily 1 group I member 2Rattus norvegicus7.9742172143.92265164381111CANCER, COLORECTAL ADENOCARCINOMA, HEPATOCELLULAR CARCINOMA, NEOPLASM, PROSTATE CARCINOMAunknown60.2647779480.2819452482526.42300440.000773639970.2093727290.217129362040.00015675511
LASOFOXIFENEpredictedEstrogen receptor betaHomo sapiens8.2395866684.7187600038.24751114OSTEOPOROSISunknown70.2614942530.275950866737.984127640.000570097780.2166123780.2270359977.20748524940.00027759133
LASOFOXIFENEpredictedEstrogen receptorHomo sapiens7.9555759173.866727757.7503798831113OSTEOPOROSISunknown70.2660.2830937231220.63779740.00090602121280.2166123780.2270359977.20748524940.00027759133
LASOFOXIFENEpredictedEstrogen receptorHomo sapiens7.9555759173.866727757.7503798831113OSTEOPOROSISunknown70.2660.2830937231220.63779740.00090602121280.2166123780.2270359977.20748524940.00027759133
CLEBOPRIDEpredictedDopamine D4 receptorHomo sapiens7.33333333328.491111DIGESTIVE SYSTEM DISEASEunknown60.2786911670.2997493731729.43779200.000998692171770.2293711860.24480156474.204212200.00030806444
BORTEZOMIBactual7.925390444YProteasome Macropain subunit MB1Homo sapiens9.3084634815.7918207827.70308261311111ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, ACUTE PROMYELOCYTIC LEUKEMIA, AL AMYLOIDOSIS, BREAST CARCINOMA, CANCER, CHRONIC LYMPHOCYTIC LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MACROGLOBULINEMIA, MANTLE CELL LYMPHOMA, MELANOMA, MESOTHELIOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NEOPLASM OF MATURE B-CELLS, NEUROBLASTOMA, NON-SMALL CELL LUNG CARCINOMA, QUALITATIVE OR QUANTITATIVE DEFECTS OF DYSFERLIN, RENAL CARCINOMA26S proteosome inhibitor70.2350462210.24670742828.8049798230.000281672260.2990314770.32513977327135.5447330.0027143011919
BORTEZOMIBactual7.925390444YNuclear factor erythroid 2-related factor 2Homo sapiens9.3084634815.6149174717.6252516541111ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, ACUTE PROMYELOCYTIC LEUKEMIA, AL AMYLOIDOSIS, BREAST CARCINOMA, CANCER, CHRONIC LYMPHOCYTIC LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MACROGLOBULINEMIA, MANTLE CELL LYMPHOMA, MELANOMA, MESOTHELIOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NEOPLASM OF MATURE B-CELLS, NEUROBLASTOMA, NON-SMALL CELL LUNG CARCINOMA, QUALITATIVE OR QUANTITATIVE DEFECTS OF DYSFERLIN, RENAL CARCINOMA26S proteosome inhibitor60.3606591570.41148062588987.9187440.006038175828260.2990314770.32513977327135.5447330.0027143011919
BORTEZOMIBactual7.925390444YNuclear factor NF-kappa-B complexHomo sapiens9.3084634817.9253904448.011113ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, ACUTE PROMYELOCYTIC LEUKEMIA, AL AMYLOIDOSIS, BREAST CARCINOMA, CANCER, CHRONIC LYMPHOCYTIC LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MACROGLOBULINEMIA, MANTLE CELL LYMPHOMA, MELANOMA, MESOTHELIOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NEOPLASM OF MATURE B-CELLS, NEUROBLASTOMA, NON-SMALL CELL LUNG CARCINOMA, QUALITATIVE OR QUANTITATIVE DEFECTS OF DYSFERLIN, RENAL CARCINOMA26S proteosome inhibitor70.2455268390.257164891805.67808630.0004643083360.2990314770.32513977327135.5447330.0027143011919
BORTEZOMIBactual7.925390444YNuclear factor NF-kappa-B complexHomo sapiens9.3084634816.2420615938.011112ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, ACUTE PROMYELOCYTIC LEUKEMIA, AL AMYLOIDOSIS, BREAST CARCINOMA, CANCER, CHRONIC LYMPHOCYTIC LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MACROGLOBULINEMIA, MANTLE CELL LYMPHOMA, MELANOMA, MESOTHELIOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NEOPLASM OF MATURE B-CELLS, NEUROBLASTOMA, NON-SMALL CELL LUNG CARCINOMA, QUALITATIVE OR QUANTITATIVE DEFECTS OF DYSFERLIN, RENAL CARCINOMA26S proteosome inhibitor70.2455268390.257164891805.67808630.0004643083360.2990314770.32513977327135.5447330.0027143011919
NORETHINDRONEpredictedEstrogen receptorRattus norvegicus7.7937554743.3812664229.21111MENOPAUSEProgesterone receptor agonist70.2660.2830937231220.63779740.00090602121270.2799546630.302018783204.881445240.00033894744
NORETHINDRONEpredictedProgesterone receptorBos taurus8.1322581514.3967744528.471112MENOPAUSEProgesterone receptor agonist70.275933610.2991627423766.44763640.001493001212170.2799546630.302018783204.881445240.00033894744
DILAZEPpredictedEquilibrative nucleoside transporter 1Homo sapiens7.33333333327.761111CARDIOVASCULAR DISEASEunknown80.2370441460.248043185317.462932630.0003006672280.2098300970.21779586329.7285753730.00030926522
TOLVAPTANpredictedVasopressin V2 receptorHomo sapiens7.5437554872.6312664629.371111CANCER, CARCINOMA, CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, CIRRHOSIS OF LIVER, CONGESTIVE HEART FAILURE, HEART FAILURE, HYPONATREMIA, KIDNEY DISEASEVasopressin V2 receptor antagonist80.2342818430.2456932173856.01092470.0008064066690.1898331140.195597051070.00019793211
FROVATRIPTANpredictedSerotonin 1b (5-HT1b) receptorHomo sapiens7.4041666792.2125000387.991111MIGRAINE DISORDER, PAINunknown60.2781531530.2987757862652.5499500.001011191171770.2329560770.2466440833.18314897100.00018217322
BOPINDOLOLpredictedBeta-1 adrenergic receptorHomo sapiens8.2249277354.6747832067.451112CARDIOVASCULAR DISEASEunknown70.2735759490.2946129062721.28015800.00109185171770.2456663820.265443829227.549068800.00046936477
BOPINDOLOLpredictedBeta-2 adrenergic receptorHomo sapiens8.2249277354.6747832067.7751112CARDIOVASCULAR DISEASEunknown70.2622876210.2790162221113.25860300.0006239339970.2456663820.265443829227.549068800.00046936477
LISURIDEpredictedAlpha-2c adrenergic receptorHomo sapiens7.620094292.8602828698.7851112MIGRAINE DISORDERunknown60.2793214860.3025448242596.31627100.001323976242470.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedAlpha-2a adrenergic receptorHomo sapiens7.6880996953.0642990859.7251112MIGRAINE DISORDERunknown60.2873047520.3163967619934.04679400.002098773363670.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedAlpha-2b adrenergic receptorHomo sapiens7.6880996953.0642990859.461112MIGRAINE DISORDERunknown60.2912735850.32122614210541.020800.002040305363670.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 6 (5-HT6) receptorHomo sapiens7.5520888852.6562666548.091112MIGRAINE DISORDERunknown60.3062345020.339917112310.5040400.001709791282870.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 1a (5-HT1a) receptorRattus norvegicus7.6880996953.0642990859.4551112MIGRAINE DISORDERunknown60.2973856210.32873538105.20939800.001297152232370.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 2b (5-HT2b) receptorHomo sapiens7.5520888852.6562666548.391112MIGRAINE DISORDERunknown60.3114193080.34829381118639.7258800.00222842383870.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 1b (5-HT1b) receptorRattus norvegicus7.6604228252.9812684768.171112MIGRAINE DISORDERunknown60.2781531530.2987757862652.5499500.001011191171770.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 2c (5-HT2c) receptorHomo sapiens7.5520888852.6562666547.851112MIGRAINE DISORDERunknown60.3037596630.3379892049528.00511500.001670615313170.2494229660.273188466454.031150400.0008790821616
LISURIDEpredictedSerotonin 2a (5-HT2a) receptorHomo sapiens7.5520888852.6562666548.791112MIGRAINE DISORDERunknown60.3051535470.34117023314148.5294300.002040502363670.2494229660.273188466454.031150400.0008790821616
SORAFENIBpredictedPlatelet-derived growth factor receptor betaHomo sapiens7.5828586634.7485759897.53810.80.910ACUTE MYELOID LEUKEMIA, BLADDER CARCINOMA, BREAST CARCINOMA, CANCER, CARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, COLORECTAL ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, HEPATOCELLULAR CARCINOMA, KELOID, KIDNEY NEOPLASM, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MELANOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OSTEOSARCOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PORTAL HYPERTENSION, PROSTATE CARCINOMA, PULMONARY HYPERTENSION, RENAL CARCINOMA, RENAL CELL CARCINOMA, SARCOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, TESTICULAR CARCINOMA, THYROID CARCINOMAunknown70.2832568810.322508194516.7195661350.000513462131370.2973856210.37385083650846.88839350.007181182194194
SORAFENIBpredictedHomeodomain-interacting protein kinase 4Homo sapiens8.2857805164.8573415478.351113ACUTE MYELOID LEUKEMIA, BLADDER CARCINOMA, BREAST CARCINOMA, CANCER, CARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, COLORECTAL ADENOCARCINOMA, GASTRIC CARCINOMA, GASTROINTESTINAL STROMAL TUMOR, HEPATOCELLULAR CARCINOMA, KELOID, KIDNEY NEOPLASM, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MELANOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OSTEOSARCOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PORTAL HYPERTENSION, PROSTATE CARCINOMA, PULMONARY HYPERTENSION, RENAL CARCINOMA, RENAL CELL CARCINOMA, SARCOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL CARCINOMA, TESTICULAR CARCINOMA, THYROID CARCINOMAunknown70.2809554760.319185326213.0958395350.000410718101070.2973856210.37385083650846.88839350.007181182194194
DARIFENACINpredictedMuscarinic acetylcholine receptor M4Homo sapiens7.5979222942.7937668838.071111NOCTURIA, POLYURIA, URINARY INCONTINENCEunknown60.2801360990.3036630042650.8432300.001281184232370.2315831770.24833374663.6851078600.00034620655
DARIFENACINpredictedMuscarinic acetylcholine receptor M3Rattus norvegicus7.5979222942.7937668838.61111NOCTURIA, POLYURIA, URINARY INCONTINENCEunknown60.2804996760.3043474073029.8775800.001343026242470.2315831770.24833374663.6851078600.00034620655
NERATINIBpredictedReceptor protein-tyrosine kinase erbB-2Homo sapiens7.7003866123.1011598357.7288888891119BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor60.3041871920.3403412387127.398779350.000677003131370.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedEpidermal growth factor receptor erbB1Homo sapiens7.4450616033.6988211718.58181818210.8636363640.93181818222BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor60.3250.36294582630142.680900.00130342242470.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedMitogen-activated protein kinase kinase kinase kinase 5Homo sapiens8.0594840334.1784520989.191111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2828861260.321206863192.2134847350.000408997101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedSPS1/STE20-related protein kinase YSK4Homo sapiens7.6500055062.9500165197.81111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.28559630.324606847534.4683177350.000543908141470.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedReceptor protein-tyrosine kinase erbB-4Homo sapiens8.0594840334.1784520988.621111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2798640340.318259936317.7099087350.000416856101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedReceptor tyrosine-protein kinase erbB-3Homo sapiens7.8291721623.4875164868.111111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2800453510.318790107336.7502737350.000447603111170.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedSerine/threonine-protein kinase 10Homo sapiens7.6500055062.9500165197.891111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor60.2965694680.332620012562.8802929350.000451507111170.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedSerine/threonine-protein kinase 25Homo sapiens7.6500055062.9500165197.921111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2848434930.32268859162.7060256350.000405003101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedSerine/threonine-protein kinase MST4Homo sapiens7.8291721623.4875164868.131111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2848434930.32268859162.7060256350.000405003101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedDual specificity mitogen-activated protein kinase kinase 2Homo sapiens7.6500055062.9500165197.591111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2777063930.316170922845.1100231350.0004156949970.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedMisshapen-like kinase 1Homo sapiens7.6500055062.9500165197.541111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor60.2953536040.331819934488.2580229350.000446843111170.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedDual specificity mitogen-activated protein kinase kinase 1Homo sapiens7.6500055062.9500165197.851111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor60.2901980530.3267399272976.33696350.000533093101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedSerine/threonine-protein kinase 24Homo sapiens7.8291721623.4875164868.191111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2844685750.322245173140.2407465350.000403438101070.2550899970.285312182866.7483148350.0017289444545
NERATINIBpredictedMitogen-activated protein kinase kinase kinase kinase 3Homo sapiens7.8291721623.4875164868.111111BREAST CARCINOMA, BREAST NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMAEpidermal growth factor receptor erbB1 inhibitor, Receptor protein-tyrosine kinase erbB-2 inhibitor70.2853135310.323450109194.5186162350.000437482111170.2550899970.285312182866.7483148350.0017289444545
BRIVANIBpredictedPlatelet-derived growth factor receptor alphaHomo sapiens7.3781249972.1343749927.961111CARCINOMA, HEPATOCELLULAR CARCINOMA, NEOPLASMFibroblast growth factor receptor inhibitor, Vascular endothelial growth factor receptor inhibitor70.2832568810.3233661081951.467821350.000664329161680.2222936490.2404328133.414061639350.00021390333
VINBLASTINE SULFATEactual7.875719129YHypoxia-inducible factor 1 alphaHomo sapiens5.9585730437.8757191297.5010.52CENTRAL NERVOUS SYSTEM CANCERTubulin inhibitor60.2754939450.296144207947.893529640.000928179141460.3119812340.3370927322573.17786140.0009903351515
VINBLASTINE SULFATEactual7.875719129YGemininHomo sapiens5.9585730437.8757191297.835647144010.51CENTRAL NERVOUS SYSTEM CANCERTubulin inhibitor60.3585649110.40891652290556.9183440.005157074757560.3119812340.3370927322573.17786140.0009903351515
DASATINIBactual7.025028006YTyrosine-protein kinase SRCHomo sapiens9.0083426696.9446275587.53893969411125ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.3016399160.3381819935049.133609350.000694693141460.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase ABLHomo sapiens9.0083426697.0250280068.93547277611137ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2991349480.3355793333196.709319350.000616628141460.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEpithelial discoidin domain-containing receptor 1Homo sapiens9.0083426697.0250280068.1527817481115ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.28559630.324606847530.1347413350.000543078141460.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-B receptor 1Homo sapiens9.0083426697.0250280069.351112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2841880340.32132942299.87537754350.0003400048860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YStem cell growth factor receptorHomo sapiens9.0083426697.0250280067.85921212511120ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2835355850.3245228463010.536614350.000815755191960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase SIK2Homo sapiens9.0083426697.0250280068.4933333331113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2795924970.31734418575.90100671350.0003408258860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase YESHomo sapiens9.0083426696.9532418919.2228269651117ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2771721710.31495634776.22210733350.0003135487760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YDual specificity mitogen-activated protein kinase kinase 5Homo sapiens9.0083426697.0250280068.481111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2801360990.319590184282.7777954350.000541349141460.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase FYNHomo sapiens9.0083426697.0250280069.31113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.3248778650.36121071929344.7231500.001025254191960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine kinase non-receptor protein 2Homo sapiens9.0083426697.0250280068.331114ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2768171630.31460932671.45080189350.0003123047760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YDual specificity testis-specific protein kinase 1Homo sapiens9.0083426697.0250280067.481112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2854077250.323835688199.5218488350.00046817121260.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YDiscoidin domain-containing receptor 2Homo sapiens9.0083426697.0250280068.5151118ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2967730860.3329477541889.209683350.000500484121260.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase BRKHomo sapiens8.1750093357.0250280068.14250.7510.8754ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2767285530.31419482831.42376407350.0002791876660.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YPlatelet-derived growth factor receptor betaHomo sapiens9.0083426697.0250280068.71251114ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2832568810.322508194516.7195661350.000513462131360.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-A receptor 5Homo sapiens9.0083426697.0250280069.621112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2824240440.320445344306.9660758350.0003843419960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YReceptor tyrosine-protein kinase erbB-3Homo sapiens9.0083426697.0250280067.741111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2800453510.318790107336.7502737350.000447603111160.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase ABL2Homo sapiens9.0083426697.0250280069.771112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2823318090.319992288127.1367992350.000345048860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YMitogen-activated protein kinase kinase kinase kinase 5Homo sapiens9.0083426697.0250280067.51113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2828861260.321206863192.2134847350.000408997101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase LCKHomo sapiens9.0083426697.0250280069.161117ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.3022727270.3397146716045.93275350.000704582161660.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YBcr/Abl fusion proteinHomo sapiens9.0083426697.0250280068.0571428571117ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2579826920.2888787973.34461828350.0001988613360.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-A receptor 3Homo sapiens9.0083426697.02502800610.031112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2818715360.3192307691791.5195350.0003894727760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-B receptor 2Homo sapiens9.0083426697.0250280068.2742352751114ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2849373760.323074169369.1424499350.00044616111160.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-B receptor 3Homo sapiens9.0083426697.0250280068.161112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2950511950.331588587501.2782224350.000446866111160.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-B receptor 4Homo sapiens9.0083426697.0250280069.3133333331113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2822396340.31967418595.63012036350.0003104987760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase BLKHomo sapiens9.0083426697.0250280069.681112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2949505290.331376518473.8693106350.000448906111160.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase TXKHomo sapiens9.0083426697.0250280068.961113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2874002660.325599714380.6699394350.00047622121260.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase SIK1Homo sapiens9.0083426697.0250280068.411112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2848434930.322621113152.509037350.000405104101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase HCKHomo sapiens9.0083426697.0250280069.3551114ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2901980530.326016965254.6268434350.0003178077760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase FGRHomo sapiens9.0083426697.0250280069.31112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2904905910.326797764796.0456347350.0004087539960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase SrmsHomo sapiens9.0083426697.0250280068.3266666671113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2822396340.31967418595.63012036350.0003104987760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YReceptor protein-tyrosine kinase erbB-4Homo sapiens9.0083426697.0250280067.331112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2798640340.318259936317.7099087350.000416856101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YPlatelet-derived growth factor receptor alphaHomo sapiens9.0083426697.0250280068.4651114ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2832568810.3233661081951.467821350.000664329161660.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase LynHomo sapiens9.0083426697.0250280069.241112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2945485520.331000578681.2522158350.000465064111160.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase TNNI3KHomo sapiens9.0083426697.0250280067.961112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2847496710.32230301134.4552989350.0003723169960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-A receptor 1Homo sapiens9.0083426697.0250280068.391112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2842814860.32147401598.63244561350.0003399388860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase SIK3Homo sapiens9.0083426697.0250280067.551111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2796829510.31772976487.3417866350.0003716389960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase FRKHomo sapiens9.0083426697.0250280069.511112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2960616440.331858492526.4484638350.000420723101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-A receptor 4Homo sapiens9.0083426697.0250280068.921112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.281963470.319616349265.2980022350.0003519628860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase SRCGallus gallus9.0083426697.0250280068.681112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.3016399160.3381819935049.133609350.000694693141460.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase CSKHomo sapiens9.0083426697.02502800691112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2904905910.326797764338.8741445350.0003824079960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YBcr/Abl fusion proteinHomo sapiens9.0083426697.0250280068.0571428571117ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2579826920.2888787973.34461828350.0001988613360.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-B receptor 6Homo sapiens9.0083426694.09376166910.411111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2847496710.322476521227.4771825350.000408695101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase RIPK2Homo sapiens9.0083426697.0250280067.3266666671113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.29029550.326402545302.1522585350.0003521888860.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YSerine/threonine-protein kinase GAKHomo sapiens9.0083426697.0250280068.591113ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2796829510.317903275135.1755708350.000409806101060.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YEphrin type-A receptor 8Homo sapiens9.0083426697.0250280069.621112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2936480980.329419703554.2402091350.000392079960.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase LCKMus musculus9.0083426697.02502800610.191111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.3022727270.3397146716045.93275350.000704582161660.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YBcr/Abl fusion proteinHomo sapiens9.0083426697.0250280068.0571428571117ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor70.2579826920.2888787973.34461828350.0001988613360.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase BMXHomo sapiens9.0083426697.0250280068.851112ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2887441550.324416811381.6415807350.000334327760.3470493780.441902834103685.357350.010730223283283
DASATINIBactual7.025028006YTyrosine-protein kinase BLKMus musculus9.0083426697.0250280068.11111ABNORMALITY OF BLOOD AND BLOOD-FORMING TISSUES, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHOLANGIOCARCINOMA, CHRONIC LYMPHOCYTIC LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, DIFFUSE LARGE B-CELL LYMPHOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, LEUKEMIA, LUNG CARCINOMA, LYMPHOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, MESOTHELIOMA, METASTATIC MELANOMA, MULTIPLE MYELOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, NON-SMALL CELL LUNG CARCINOMA, PANCREATIC CARCINOMA, POLYCYTHEMIA VERA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SMALL CELL LUNG CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMAEphrin type-A receptor 2 inhibitor, Platelet-derived growth factor receptor beta inhibitor, SRC inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase ABL inhibitor60.2949505290.331376518473.8693106350.000448906111160.3470493780.441902834103685.357350.010730223283283
TARANABANTpredictedCytochrome P450 2D6Homo sapiens7.7910486423.3731459279.231111OBESITY, TYPE II DIABETES MELLITUSCannabinoid CB1 receptor inverse agonist70.27842190.30157261311858.287200.001801674222270.2566805230.274171693129.394941230.00033558944
TARANABANTpredictedCytochrome P450 2C9Homo sapiens7.7910486423.3731459279.031111OBESITY, TYPE II DIABETES MELLITUSCannabinoid CB1 receptor inverse agonist60.3037596630.33602274914261.7928730.001910128282870.2566805230.274171693129.394941230.00033558944
TARANABANTpredictedCytochrome P450 3A4Homo sapiens7.5979222942.7937668837.6989700041111OBESITY, TYPE II DIABETES MELLITUSCannabinoid CB1 receptor inverse agonist60.3140210680.35080007718362.3918330.001678849232370.2566805230.274171693129.394941230.00033558944
TARANABANTpredictedCytochrome P450 1A2Homo sapiens7.5979222942.7937668837.6989700041111OBESITY, TYPE II DIABETES MELLITUSCannabinoid CB1 receptor inverse agonist70.2746188060.2951678652463.11772530.001026202141470.2566805230.274171693129.394941230.00033558944
VASOPRESSINpredictedVasopressin V2 receptorSus scrofa8.3128449964.9385349898.481111AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist80.2342818430.2456932173856.01092470.0008064066670.2602347980.2790148453296.5304670.00052686644
VASOPRESSINpredictedVasopressin V2 receptorRattus norvegicus8.0353243134.1059729399.2216166741113AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist80.2342818430.2456932173856.01092470.0008064066670.2602347980.2790148453296.5304670.00052686644
VASOPRESSINpredictedVasopressin V2 receptorBos taurus8.2070123074.6210369218.821111AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist80.2342818430.2456932173856.01092470.0008064066670.2602347980.2790148453296.5304670.00052686644
VASOPRESSINpredictedVasopressin V1a receptorRattus norvegicus8.0009867144.0029601439.5081115AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist70.2457362140.2577418823265.00288370.0007049226670.2602347980.2790148453296.5304670.00052686644
VASOPRESSINpredictedVasopressin V2 receptorHomo sapiens7.997627363.992882089.3286224451119AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist80.2342818430.2456932173856.01092470.0008064066670.2602347980.2790148453296.5304670.00052686644
VASOPRESSINpredictedVasopressin V1a receptorHomo sapiens7.8642915354.3071603198.65785714310.9285714290.96428571414AUTISM SPECTRUM DISORDER, HEMORRHAGE, INJURY, SEPTIC SHOCK, SUDDEN CARDIAC ARREST, UNIPOLAR DEPRESSION, UTERINE FIBROIDVasopressin receptor agonist70.2457362140.2577418823265.00288370.0007049226670.2602347980.2790148453296.5304670.00052686644
LINIFANIBpredictedTyrosine-protein kinase receptor FLT3Homo sapiens7.4014579812.7926092368.26176470610.9411764710.97058823517HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor70.2761098690.3160098051180.098712350.000588806141470.2356870230.259346168104.0351649350.0008316512121
LINIFANIBpredictedVascular endothelial growth factor receptor 3Homo sapiens7.5032471722.5097415177.6441115HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor70.2916666670.3291456661284.365223350.000541215131370.2356870230.259346168104.0351649350.0008316512121
LINIFANIBpredictedMacrophage colony stimulating factor receptorHomo sapiens7.5457256322.6371768978.391114HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor60.2967730860.3344900711710.245087350.00068056171770.2356870230.259346168104.0351649350.0008316512121
LINIFANIBpredictedPlatelet-derived growth factor receptor alphaHomo sapiens7.5575431592.6726294768.021113HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor70.2832568810.3233661081951.467821350.000664329161670.2356870230.259346168104.0351649350.0008316512121
LINIFANIBpredictedMuscle- skeletal receptor tyrosine protein kinaseHomo sapiens7.6061063952.81831918581112HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor60.2946489430.331145171483.4268958350.000446296111170.2356870230.259346168104.0351649350.0008316512121
LINIFANIBpredictedEphrin type-B receptor 6Homo sapiens7.5716667062.7150001187.481111HEPATOCELLULAR CARCINOMA, NEOPLASM, RENAL CELL CARCINOMAMacrophage colony stimulating factor receptor inhibitor, Platelet-derived growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor inhibitor70.2847496710.322476521227.4771825350.000408695101070.2356870230.259346168104.0351649350.0008316512121
BEDAQUILINEpredictedPutative uncharacterized protein atpEMycobacterium smegmatis8.3633860175.090158058.21113LIVER DISEASE, TUBERCULOSISunknown1110210.000558036111110210.00055803611
APIXABANpredictedCoagulation factor XHomo sapiens7.8059184073.41775522210.11118ACUTE CORONARY SYNDROME, ATRIAL FIBRILLATION, CHRONIC KIDNEY DISEASE, DEEP VEIN THROMBOSIS, OBESITY, PULMONARY EMBOLISM, RECURRENT THROMBOPHLEBITIS, SICKLE CELL ANEMIA, STROKE, VENOUS THROMBOEMBOLISM, VENOUS THROMBOSIS, VENTRICULAR TACHYCARDIACoagulation factor X inhibitor1110220.000558036111110220.00055803611
APIXABANpredictedCoagulation factor XOryctolagus cuniculus7.8645650613.5936951849.771111ACUTE CORONARY SYNDROME, ATRIAL FIBRILLATION, CHRONIC KIDNEY DISEASE, DEEP VEIN THROMBOSIS, OBESITY, PULMONARY EMBOLISM, RECURRENT THROMBOPHLEBITIS, SICKLE CELL ANEMIA, STROKE, VENOUS THROMBOEMBOLISM, VENOUS THROMBOSIS, VENTRICULAR TACHYCARDIACoagulation factor X inhibitor1110220.000558036111110220.00055803611
DIGITOXINactual7.669131508YNuclear factor NF-kappa-B p105 subunitHomo sapiens9.2230438367.6691315087.4888353121112CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor60.2898089170.3201465221962.2941440.002876854383860.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YSodium/potassium-transporting ATPaseHomo sapiens9.2230438367.6691315088.11117CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor70.2518205650.2628411691.09173230640.0002007622260.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YNuclear factor NF-kappa-B p105 subunitHomo sapiens9.2230438367.6691315087.4888353121112CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor60.2898089170.3201465221962.2941440.002876854383860.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YSodium/potassium-transporting ATPaseHomo sapiens9.2230438367.6691315088.11117CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor70.2518205650.2628411691.09173230640.0002007622260.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YSodium/potassium-transporting ATPaseHomo sapiens9.2230438367.6691315088.11111CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor70.2518205650.2628411691.09173230640.0002007622260.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YRetinoid X receptor alphaHomo sapiens9.2230438367.6691315087.625039131112CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor60.2834426230.3097262396386.9856940.001646278242460.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YCellular tumor antigen p53Homo sapiens5.8897105037.6691315087.5010.51CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor60.2815960910.3040871411600.18412240.00091984141460.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YSodium/potassium-transporting ATPase alpha-1 chainCanis lupus familiaris9.2230438367.6691315088.11111CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor70.2575215970.26979123640.4230950740.0002564553360.3326279340.35865625611993.6556640.0017198682525
DIGITOXINactual7.669131508YSodium/potassium-transporting ATPase alpha-1 chainCanis lupus familiaris9.2230438367.6691315088.11111CARDIOVASCULAR DISEASE, CYSTIC FIBROSISSodium/potassium-transporting ATPase inhibitor70.2575215970.26979123640.4230950740.0002564553360.3326279340.35865625611993.6556640.0017198682525
IRBESARTANpredictedAngiotensin II receptorHomo sapiens7.8808397573.6425192728.521112ATRIAL FIBRILLATION, CARDIOVASCULAR DISEASE, CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, CONGESTIVE HEART FAILURE, FOCAL SEGMENTAL GLOMERULOSCLEROSIS, HEART DISEASE, HYPERCHOLESTEROLEMIA, HYPERTENSION, MARFAN SYNDROME, SEPSISType-1 angiotensin II receptor antagonist80.2323924730.2461827653858.195318110.0010139549970.2535934290.2747238985812.208615110.00044454833
OLMESARTANpredictedAngiotensin II type 1a (AT-1a) receptorBos taurus7.6645841282.9937523848.0966666671113ATRIAL FIBRILLATION, HYPERTENSIONunknown80.2301038060.2420185082740.778757110.0006263375590.1886730690.1959332864.938632371110.00028591822
NILOTINIBpredictedTyrosine-protein kinase ABL2Homo sapiens8.0375154254.1125462767.591111ACUTE GRAFT VS. HOST DISEASE, ACUTE LYMPHOBLASTIC LEUKEMIA, ACUTE MYELOID LEUKEMIA, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHORDOMA, CHRONIC MYELOGENOUS LEUKEMIA, CUTANEOUS MELANOMA, GASTROINTESTINAL STROMAL TUMOR, LEUKEMIA, MELANOMA, METASTATIC MELANOMA, NEOPLASM, NON-HODGKINS LYMPHOMA, PARKINSON'S DISEASE, PULMONARY HYPERTENSIONunknown70.2823318090.319992288127.1367992350.000345048870.2540405520.277844336516.1383992350.0009716722424
ANGIOTENSIN IIpredictedAngiotensin II type 2 (AT-2) receptorHomo sapiens8.2287868164.6863604489.321117SEPTIC SHOCKunknown80.2347271250.246731527481.6204227110.0003491333380.1984618920.2070099788.86996986110.00067300766
ANGIOTENSIN IIpredictedAngiotensin II receptorRattus norvegicus8.318021034.9540630898.71411115SEPTIC SHOCKunknown80.2323924730.2461827653858.195318110.0010139549980.1984618920.2070099788.86996986110.00067300766
ANGIOTENSIN IIpredictedType-1B angiotensin II receptorRattus norvegicus8.2775674334.83270239.311113SEPTIC SHOCKunknown80.2347908750.2471171061168.581636110.0004676434480.1984618920.2070099788.86996986110.00067300766
ANGIOTENSIN IIpredictedAngiotensin II type 1a (AT-1a) receptorBos taurus8.2070123074.6210369218.241111SEPTIC SHOCKunknown80.2301038060.2420185082740.778757110.0006263375580.1984618920.2070099788.86996986110.00067300766
ANGIOTENSIN IIpredictedType-1A angiotensin II receptorRattus norvegicus8.2070123074.6210369219.41111SEPTIC SHOCKunknown70.244900850.2567338682159.703983110.000468014480.1984618920.2070099788.86996986110.00067300766
DACTINOMYCINactual8.422180183YThyroid hormone receptor beta-1Homo sapiens9.4740600617.8014844978.2275321171112HYDATIDIFORM MOLEDNA inhibitor60.2787810380.30386543312097.9095140.001979349252560.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YPeroxisome proliferator-activated receptor deltaHomo sapiens8.9185045057.8177822597.49842396510.8333333330.9166666676HYDATIDIFORM MOLEDNA inhibitor60.34901090.39550800185678.0111640.005261171686860.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YAndrogen ReceptorHomo sapiens9.4740600618.1437949457.890250131118HYDATIDIFORM MOLEDNA inhibitor60.3808370040.4451417265199.967340.01213448314714760.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YNuclear receptor ROR-gammaHomo sapiens9.4740600618.2578984287.5751183631111HYDATIDIFORM MOLEDNA inhibitor60.2900033550.3193560838301.016440.001948329292960.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YCellular tumor antigen p53Homo sapiens6.1407267286.4111156328.698970004010.51HYDATIDIFORM MOLEDNA inhibitor60.2815960910.3040871411600.18412240.00091984141460.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YRetinoid X receptor alphaHomo sapiens9.4740600618.2578984287.7672919271113HYDATIDIFORM MOLEDNA inhibitor60.2834426230.3097262396386.9856940.001646278242460.3305927340.35664160413196.7357740.0017018832424
DACTINOMYCINactual8.422180183YHuntingtinHomo sapiens6.1407267286.8166351377.5010.51HYDATIDIFORM MOLEDNA inhibitor60.307980050.3424908421958.98752540.0005262678860.3305927340.35664160413196.7357740.0017018832424
ATROPINEpredictedMuscarinic acetylcholine receptors; M1 & M2Homo sapiens7.5520888852.6562666549.171112AMBLYOPIA, DIGESTIVE SYSTEM DISEASE, HYPOGLYCEMIA, MYOPIA, PAIN, PNEUMONIA, SEASONAL ALLERGIC RHINITISMuscarinic acetylcholine receptor M1 antagonist, Muscarinic acetylcholine receptor M2 antagonist, Muscarinic acetylcholine receptor M3 antagonist80.1950586640.203908122000.000140791170.2422926010.2606819251760.68500600.00053713188
ATROPINEpredictedMuscarinic acetylcholine receptor M1Mus musculus7.33333333329.221848751111AMBLYOPIA, DIGESTIVE SYSTEM DISEASE, HYPOGLYCEMIA, MYOPIA, PAIN, PNEUMONIA, SEASONAL ALLERGIC RHINITISMuscarinic acetylcholine receptor M1 antagonist, Muscarinic acetylcholine receptor M2 antagonist, Muscarinic acetylcholine receptor M3 antagonist60.2888406280.3174667449434.89423600.001795345313170.2422926010.2606819251760.68500600.00053713188
BUPRENORPHINEpredictedDelta opioid receptorMus musculus8.1373793254.4121379767.8239087411111CANCER, COCAINE DEPENDENCE, CONSTIPATION, DRUG DEPENDENCE, EATING DISORDER, EPILEPSY, HEROIN DEPENDENCE, HIV INFECTION, LUMBAR DISC DEGENERATION, NEONATAL ABSTINENCE SYNDROME, OPIATE DEPENDENCE, OSTEOARTHRITIS, PAIN, PRURITUS, RESTLESS LEGS SYNDROME, UNIPOLAR DEPRESSIONKappa opioid receptor agonist, Mu opioid receptor agonist60.2813211850.3020339316952.40376800.000919284121270.2337118140.2503387591103.64087500.00054157366
CEDIRANIBpredictedEpithelial discoidin domain-containing receptor 1Homo sapiens7.9395943033.8187829098.771111CANCER, COLORECTAL ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, LUNG CARCINOMA, NEOPLASM, OVARIAN CARCINOMA, RENAL CELL CARCINOMAPlatelet-derived growth factor receptor inhibitor, Stem cell growth factor receptor inhibitor, Vascular endothelial growth factor receptor inhibitor70.28559630.324606847530.1347413350.000543078141470.2523350850.3017681571865.774202350.003802884105105
CEDIRANIBpredictedSerine/threonine-protein kinase 35Homo sapiens7.9395943033.8187829098.271111CANCER, COLORECTAL ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, LUNG CARCINOMA, NEOPLASM, OVARIAN CARCINOMA, RENAL CELL CARCINOMAPlatelet-derived growth factor receptor inhibitor, Stem cell growth factor receptor inhibitor, Vascular endothelial growth factor receptor inhibitor70.2797734630.318115343100.4506293350.000404198101070.2523350850.3017681571865.774202350.003802884105105
APOMORPHINE HYDROCHLORIDEpredictedDopamine receptorRattus norvegicus8.1916887074.5750661218.431115PARKINSON'S DISEASED2-like dopamine receptor agonist70.2711731490.2879520231573.12786900.0006528479970.2650214590.289581096502.155426200.00036730155
CLEMASTINEpredictedMuscarinic acetylcholine receptor M4Homo sapiens8.2261866324.6785598968.131112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.2801360990.3036630042650.8432300.001281184232370.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedDopamine D3 receptorHomo sapiens8.192362994.577088978.3651112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.289614740.3209465979204.65765900.002356341424270.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedMuscarinic acetylcholine receptor M5Homo sapiens8.192362994.577088978.151112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.2761980830.2978600352256.16260800.001183478212170.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedMuscarinic acetylcholine receptor M3Homo sapiens8.2261866324.6785598967.7451112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.2804996760.3043474073029.8775800.001343026242470.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedAlpha-1d adrenergic receptorHomo sapiens8.2600102744.7800308237.6551112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.2810468140.3042799312336.53166200.001223953222270.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedSerotonin 2a (5-HT2a) receptorHomo sapiens8.2261866324.6785598967.7651112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.3051535470.34117023314148.5294300.002040502363670.2667386610.2972789121794.16933100.0013569842525
CLEMASTINEpredictedHistamine H1 receptorHomo sapiens8.192362994.577088979.8451112OPTIC NEURITIS, PRURITUS, RELAPSING-REMITTING MULTIPLE SCLEROSISunknown60.2804086930.3024387893868.93481400.001146468191970.2667386610.2972789121794.16933100.0013569842525
PANOBINOSTATpredictedHistone deacetylasePlasmodium falciparum7.6965295983.0895887938.741111ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHRONIC MYELOGENOUS LEUKEMIA, CUTANEOUS T-CELL LYMPHOMA, DIFFUSE LARGE B-CELL LYMPHOMA, GASTRIC CARCINOMA, GLIOBLASTOMA MULTIFORME, HIV INFECTION, HODGKINS LYMPHOMA, LEUKEMIA, LYMPHOMA, MACROGLOBULINEMIA, MELANOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NON-HODGKINS LYMPHOMA, PROSTATE CARCINOMA, RENAL CELL CARCINOMA, SARCOMA, SICKLE CELL ANEMIA, THYROID CARCINOMAunknown70.2639694660.2977994448056.56565250.0008193966680.2089173510.224546256172850.0004241322
PANOBINOSTATpredictedHistone deacetylaseHomo sapiens7.6693697185.5081091557.5210.750.8754ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CANCER, CENTRAL NERVOUS SYSTEM CANCER, CHRONIC MYELOGENOUS LEUKEMIA, CUTANEOUS T-CELL LYMPHOMA, DIFFUSE LARGE B-CELL LYMPHOMA, GASTRIC CARCINOMA, GLIOBLASTOMA MULTIFORME, HIV INFECTION, HODGKINS LYMPHOMA, LEUKEMIA, LYMPHOMA, MACROGLOBULINEMIA, MELANOMA, MULTIPLE MYELOMA, MYELODYSPLASTIC SYNDROME, NEOPLASM, NON-HODGKINS LYMPHOMA, PROSTATE CARCINOMA, RENAL CELL CARCINOMA, SARCOMA, SICKLE CELL ANEMIA, THYROID CARCINOMAunknown70.2639694660.2977994448056.56565250.0008193966680.2089173510.224546256172850.0004241322
NAVITOCLAXpredictedBcl2-antagonist of cell death (BAD)Homo sapiens8.2729300274.8187900829.1505149981112CANCER, CHRONIC LYMPHOCYTIC LEUKEMIA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, SMALL CELL LUNG CARCINOMAunknown80.1673117860.170781349040.0002378761170.2009063440.2070065271728.540.00054407333
DONEPEZIL HYDROCHLORIDEpredictedAcetylcholinesteraseMus musculus7.7791775843.3375327528.241111ALZHEIMERS DISEASE, AUTISM, CHRONIC KIDNEY DISEASE, COGNITIVE IMPAIRMENT, DEMENTIA, DOWN SYNDROME, MIGRAINE DISORDERAcetylcholinesterase inhibitor60.2728851010.2907750146150.35234600.001071529121270.2144097220.222245173000.00015959111
DONEPEZIL HYDROCHLORIDEpredictedAcetylcholinesteraseTorpedo californica7.5729221342.7187664028.241111ALZHEIMERS DISEASE, AUTISM, CHRONIC KIDNEY DISEASE, COGNITIVE IMPAIRMENT, DEMENTIA, DOWN SYNDROME, MIGRAINE DISORDERAcetylcholinesterase inhibitor60.2728851010.2907750146150.35234600.001071529121270.2144097220.222245173000.00015959111
DONEPEZIL HYDROCHLORIDEpredictedAcetylcholinesteraseBos taurus7.5729221342.7187664028.091111ALZHEIMERS DISEASE, AUTISM, CHRONIC KIDNEY DISEASE, COGNITIVE IMPAIRMENT, DEMENTIA, DOWN SYNDROME, MIGRAINE DISORDERAcetylcholinesterase inhibitor60.2728851010.2907750146150.35234600.001071529121270.2144097220.222245173000.00015959111
NILVADIPINEpredictedVoltage-gated L-type calcium channelRattus norvegicus7.8483223293.5449669878.981113ALZHEIMERS DISEASE, CARDIOVASCULAR DISEASEunknown70.2606270730.2764135613534.17871800.0008261829980.2067687160.214014432000.0001617211
CARFILZOMIBactual7.175223538YProteasome subunit beta type-8Homo sapiens9.0584078463.9625722757.851111ACUTE GRAFT VS. HOST DISEASE, ACUTE LYMPHOBLASTIC LEUKEMIA, CANCER, LEUKEMIA, LYMPHOMA, MULTIPLE MYELOMA, NEOPLASM, RENAL CARCINOMA26S proteosome inhibitor70.2350462210.24670742828.8049798230.000281672260.3052612990.3296799697392.8396530.0011700751313
NINTEDANIBpredictedTyrosine-protein kinase LCKHomo sapiens7.5437554842.6312664517.9366666671113ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown60.3022727270.3397146716045.93275350.000704582161670.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedVascular endothelial growth factor receptor 2Mus musculus7.61250732.8375219017.891111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown60.3028021020.3408039336857.75835350.00089742202070.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedPlatelet-derived growth factor receptor betaHomo sapiens7.5437554842.6312664517.9033333331113ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2832568810.322508194516.7195661350.000513462131370.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedSerine/threonine-protein kinase 11Homo sapiens7.61250732.8375219017.741111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown60.2946489430.331145171441.8967398350.00044388111170.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedTyrosine-protein kinase JAK3Homo sapiens7.406251852.2187555518.091111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2711731490.30908727944.53049134350.000280696670.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedTyrosine-protein kinase JAK3Homo sapiens7.406251852.2187555518.091111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2711731490.30908727944.53049134350.000280696670.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedTyrosine-protein kinase receptor UFOHomo sapiens7.61250732.8375219017.921111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown60.2949505290.331376518486.3247234350.000448133111170.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedDual specificity protein kinase TTKHomo sapiens7.61250732.8375219017.661111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.276905830.31499490589.40718725350.0003451998870.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedSerine/threonine-protein kinase PRP4 homologHomo sapiens7.406251852.2187555518.081111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2797734630.318115343119.5947718350.000404659101070.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedNeurotrophic tyrosine kinase receptor type 2Homo sapiens7.61250732.8375219017.721111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2761098690.31385331576.84935367350.000280356670.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedSerine/threonine-protein kinase PCTAIRE-1Homo sapiens7.61250732.8375219017.681111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2771721710.315910656365.3534703350.00041824101070.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedcGMP-dependent protein kinase 1 betaHomo sapiens7.61250732.8375219017.851111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2882627540.324287367323.1969736350.0003571018870.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedMitogen-activated protein kinase kinase kinase 2Homo sapiens7.406251852.2187555518.031111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.28521940.32398992449.5804668350.000508548131370.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedInsulin receptor-related proteinHomo sapiens7.61250732.8375219017.681111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown60.2945485520.330759591412.4314158350.000413067101070.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedMaternal embryonic leucine zipper kinaseHomo sapiens7.406251852.2187555518.311111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2862582780.322378749220.6799197350.0003201857770.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedDual specificity protein kinase CLK4Homo sapiens7.61250732.8375219017.741111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2755817660.313426423874.3090665350.000399518870.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedSerine/threonine-protein kinase pknBMycobacterium tuberculosis7.406251852.2187555518.441111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2796829510.317729764107.5264429350.0003738459970.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedDual specificity mitogen-activated protein kinase kinase 5Homo sapiens7.406251852.2187555518.741111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2801360990.319590184282.7777954350.000541349141470.2455965910.275095706580.3026379350.001552584040
NINTEDANIBpredictedG protein-coupled receptor kinase 4Homo sapiens7.61250732.8375219017.771111ACUTE MYELOID LEUKEMIA, BREAST CARCINOMA, CARCINOID TUMOR, CERVICAL ADENOCARCINOMA, GASTRIC ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, IDIOPATHIC PULMONARY FIBROSIS, MESOTHELIOMA, MULTIPLE MYELOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, PROSTATE ADENOCARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, SYSTEMIC SCLERODERMA, THYROID CARCINOMAunknown70.2802269040.318876862149.656558350.000437139111170.2455965910.275095706580.3026379350.001552584040
MORPHINE HYDROCHLORIDEpredictedMu opioid receptorHomo sapiens7.521875012.565625037.4202164031111OPIATE DEPENDENCEunknown70.2829787230.30628081210082.8795500.00121941171770.2247789910.2363201967.29298457600.00026762533
DIGOXINactual6.871944335YNuclear factor NF-kappa-B p105 subunitHomo sapiens8.9573147786.8719443357.912476151112ATRIAL FIBRILLATION, BREAST CARCINOMA, CARDIOVASCULAR DISEASE, CONGESTIVE HEART FAILURE, EPILEPSY, HEART FAILURE, HEPATITIS C INFECTION, HIV INFECTION, HYPERTENSION, PROSTATE CARCINOMA, RHEUMATOID ARTHRITIS, TYPE II DIABETES MELLITUS, VERRUCAESodium/potassium-transporting ATPase inhibitor60.2898089170.3201465221962.2941440.002876854383860.3332690820.36122999815884.4388240.0022042513232
DIGOXINactual6.871944335YNuclear factor NF-kappa-B p105 subunitHomo sapiens8.9573147786.8719443357.912476151112ATRIAL FIBRILLATION, BREAST CARCINOMA, CARDIOVASCULAR DISEASE, CONGESTIVE HEART FAILURE, EPILEPSY, HEART FAILURE, HEPATITIS C INFECTION, HIV INFECTION, HYPERTENSION, PROSTATE CARCINOMA, RHEUMATOID ARTHRITIS, TYPE II DIABETES MELLITUS, VERRUCAESodium/potassium-transporting ATPase inhibitor60.2898089170.3201465221962.2941440.002876854383860.3332690820.36122999815884.4388240.0022042513232
LESTAURTINIBactual7.124938737YDual specificity protein kinase CLK2Homo sapiens9.0416462467.1249387377.361112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2747060690.311151505510.2232819350.0002593244460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNerve growth factor receptor Trk-AHomo sapiens9.0416462467.1249387378.081112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2901006710.325752568256.9068146350.0003199177760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase JAK2Homo sapiens9.0416462467.1249387378.431112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2762863530.31339475126.97427971350.000247245560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens9.0416462467.1249387378.241112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2796829510.31772976488.58566189350.0003733849960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YG protein-coupled receptor kinase 4Homo sapiens9.0416462467.1249387377.921112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2802269040.318876862149.656558350.000437139111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCyclin-dependent kinase-like 2Homo sapiens9.0416462467.1249387377.371112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2854077250.323835688230.4981303350.000468944121260.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YAdaptor-associated kinaseHomo sapiens9.0416462467.1249387378.511112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2768171630.31460932677.27098461350.0003126397760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase Chk1Homo sapiens9.0416462467.1249387378.551112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2854077250.320894269232.4463357350.0002728495560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificty protein kinase CLK1Homo sapiens9.0416462467.1249387378.021112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2764630640.31423338696.94989695350.0003149147760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 3Homo sapiens9.0416462467.1249387378.31112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.32230301134.4552989350.0003723169960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YEukaryotic translation initiation factor 2-alpha kinase 4Homo sapiens9.0416462467.1249387378.391111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.32230301134.4552989350.0003723169960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PAK 4Homo sapiens9.0416462467.1249387377.621112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2710031350.3083161211.95307178350.0002149834460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YVascular endothelial growth factor receptor 3Homo sapiens9.0416462467.1249387377.771112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2916666670.3291456661284.365223350.000541215131360.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YBR serine/threonine-protein kinase 2Homo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2945485520.330759591390.9319765350.00041086101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine kinase non-receptor protein 2Homo sapiens9.0416462467.1249387378.181111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2768171630.31460932671.45080189350.0003123047760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMAP/microtubule affinity-regulating kinase 2Homo sapiens9.0416462467.1249387377.851112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2742703050.31177118699.20389171350.0002519245560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PRKXHomo sapiens9.0416462467.1249387377.381112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2700718530.3072075793.096295107350.0001825033360.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PIM3Homo sapiens9.0416462467.1249387377.741112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2920608110.327829188288.4572905350.0003496018860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YBMP-2-inducible protein kinaseHomo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2767285530.31422374650.89397077350.0002796186660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 17BHomo sapiens9.0416462467.1249387378.31112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2787810380.31640915583.62988257350.0003434568860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase RIO3Homo sapiens9.0416462467.1249387378.111112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.322235534122.7797102350.0003724189960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMaternal embryonic leucine zipper kinaseHomo sapiens9.0416462467.1249387377.591112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2862582780.322378749220.6799197350.0003201857760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase FERHomo sapiens9.0416462467.1249387377.551112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.285125330.320286981121.4701833350.0002226114460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase D2Homo sapiens9.0416462467.1249387378.091112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2747060690.31265526556.45557554350.0003415028860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase ULK3Homo sapiens9.0416462467.1249387378.311112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2950511950.33152111435.8586458350.00044334111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase Aurora-CHomo sapiens9.0416462467.1249387378.391112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.293150220.328619626294.2162272350.0003513998860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual-specificity tyrosine-phosphorylation regulated kinase 2Homo sapiens9.0416462467.1249387377.661112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2945485520.330759591416.6827054350.000414428101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiens9.0416462467.1249387377.541112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2708333330.30909691840.63906577350.0002818236660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTRAF2- and NCK-interacting kinaseHomo sapiens9.0416462467.1249387378.271112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2771721710.31495634764.89966469350.0003121287760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCyclin-dependent kinase-like 5Homo sapiens9.0416462467.12493873781112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMAP kinase signal-integrating kinase 2Homo sapiens9.0416462467.1249387378.851112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2939476370.33022942558.9121793350.000454716111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase receptor FLT3Homo sapiens9.0416462467.1249387378.47933333311115ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2761098690.3160098051180.098712350.000588806141460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProto-oncogene tyrosine-protein kinase MERHomo sapiens9.0416462467.1249387377.491112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2951519290.33190669514.5117327350.000478545121260.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 4Homo sapiens9.0416462467.1249387378.421112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 17AHomo sapiens9.0416462467.1249387378.471112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2708333330.30909691840.63906577350.0002818236660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMisshapen-like kinase 1Homo sapiens9.0416462467.1249387378.441112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2953536040.331819934488.2580229350.000446843111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PAK6Homo sapiens9.0416462467.12493873781112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2886477460.324031232191.3630946350.0002874286660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity protein kinase CLK4Homo sapiens9.0416462467.1249387378.521112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2755817660.313426423874.3090665350.000399518860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity protein kinase TTKHomo sapiens9.0416462467.1249387378.191112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.276905830.31499490589.40718725350.0003451998860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual-specificity tyrosine-phosphorylation regulated kinase 1AHomo sapiens9.0416462467.1249387377.71112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2707485120.30871133933.60363689350.0002492635560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase GAKHomo sapiens9.0416462467.1249387378.141112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2796829510.317903275135.1755708350.000409806101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMyosin light chain kinase family member 4Homo sapiens9.0416462467.1249387377.541112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 15Homo sapiens9.0416462467.1249387378.471112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2795924970.31734418575.90100671350.0003408258860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YStem cell growth factor receptorHomo sapiens9.0416462467.1249387377.2777777781119ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2835355850.3245228463010.536614350.000815755191960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMicrotubule-associated serine/threonine-protein kinase 1Homo sapiens9.0416462467.1249387377.721112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProtein kinase C nuHomo sapiens9.0416462467.1249387378.051112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.276905830.313420915614.1437496350.0002903955560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 2Homo sapiens9.0416462467.1249387378.321112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.28521940.32398992449.5804668350.000508548131360.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase TBK1Homo sapiens9.0416462467.1249387377.741112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.285125330.320286981121.4701833350.0002226114460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 33Homo sapiens9.0416462467.1249387377.591112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2944482290.330374012362.0942014350.0003800469960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YPhosphatidylinositol-5-phosphate 4-kinase type-2 betaHomo sapiens9.0416462467.1249387377.741112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNUAK family SNF1-like kinase 2Homo sapiens9.0416462467.12493873791112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2830713820.321737035179.148799350.000437225111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase SIK2Homo sapiens9.0416462467.1249387377.821112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2795924970.31734418575.90100671350.0003408258860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase JAK2Homo sapiens9.0416462467.1249387378.431112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2762863530.31339475126.97427971350.000247245560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 3Homo sapiens9.0416462467.1249387378.221112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2800453510.318105704100.3984651350.0003733049960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 7Homo sapiens9.0416462467.1249387378.541112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2966712420.33283208606.7535666350.000449467111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase kinase 1Homo sapiens9.0416462467.1249387377.421112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2854077250.323835688214.4878618350.000470042121260.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase kinase 4Homo sapiens9.0416462467.1249387377.641112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2754939450.313551736532.8264132350.000365598860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase kinase 2Homo sapiens9.0416462467.1249387378.331112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2863530970.322484783231.8027079350.0003201567760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase JAK3Homo sapiens9.0416462467.1249387378.641112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2711731490.30908727944.53049134350.000280696660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase SYKHomo sapiens9.0416462467.1249387378.021112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.275933610.313018811292.1547847350.000272335560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase Aurora-AHomo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.29029550.3265760563354.359991350.0005329349960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInhibitor of nuclear factor kappa B kinase alpha subunitHomo sapiens9.0416462467.1249387378.051112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2715138190.30948249723.05771105350.0002467495560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YBR serine/threonine-protein kinase 1Homo sapiens9.0416462467.1249387377.61112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2745315970.31188410629.89580813350.0002780026660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 1Homo sapiens9.0416462467.1249387378.461112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2901980530.3267399272976.33696350.000533093101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 2Homo sapiens9.0416462467.1249387378.411112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2777063930.316170922845.1100231350.0004156949960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCyclin-dependent kinase 2Homo sapiens9.0416462467.1249387377.71112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.270579030.30818116714.84698679350.0002148824460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProtein kinase C muHomo sapiens9.0416462467.1249387377.851112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2945485520.330759591596.9212822350.000422655101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual serine/threonine and tyrosine protein kinaseHomo sapiens9.0416462467.1249387378.281111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2796829510.31772976487.3417866350.0003716389960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 6Homo sapiens9.0416462467.1249387377.361112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2945485520.330759591390.9319765350.00041086101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase receptor RETHomo sapiens9.0416462467.1249387377.951115ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2838148390.3245806822421.142611350.00074186181860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YRhodopsin kinaseHomo sapiens9.0416462467.1249387377.621112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2796829510.31772976487.3417866350.0003716389960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNT-3 growth factor receptorHomo sapiens9.0416462467.1249387377.851112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2767285530.315212482211.6298007350.000352138860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737Yc-Jun N-terminal kinase 1Homo sapiens9.0416462467.1249387377.961112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.285879630.321896775194.733752350.0003203377760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 10Homo sapiens9.0416462467.1249387377.821112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2772610650.31516841653.79253211350.0003097537760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PAK7Homo sapiens9.0416462467.1249387377.621112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2761098690.313548982149.8897953350.0002899296660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase LATS1Homo sapiens9.0416462467.1249387377.521112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase kinase 5Homo sapiens9.0416462467.1249387377.371112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2828861260.321206863192.2134847350.000408997101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNon-receptor tyrosine-protein kinase TNK1Homo sapiens9.0416462467.1249387378.031112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.28521940.323064529163.4892935350.000404796101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase 15Homo sapiens9.0416462467.1249387378.311112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2952527320.332118758869.8200284350.000484692121260.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCaM kinase II alphaHomo sapiens9.0416462467.12493873781112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.270579030.30818116714.84698679350.0002148824460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCaM-kinase kinase betaHomo sapiens9.0416462467.1249387377.821112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2863530970.322484783347.1062788350.0003300797760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PLK4Homo sapiens9.0416462467.1249387378.821112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2829787230.321351456383.7674318350.000415709101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCaM-kinase kinase alphaHomo sapiens9.0416462467.1249387377.641112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2897117960.326007326313.3208861350.00038319960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCaM kinase II deltaHomo sapiens9.0416462467.1249387378.061112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.28521940.320672561137.9889327350.0002551715560.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInhibitor of nuclear factor kappa B kinase beta subunitHomo sapiens9.0416462467.1249387377.921112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2886477460.324730783494.5994102350.0003665098860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCalcium-dependent protein kinase 1Plasmodium falciparum (isolate 3D7)9.0416462467.1249387378.251111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2844685750.322245173159.1689426350.000405193101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInterleukin-1 receptor-associated kinase 1Homo sapiens9.0416462467.1249387378.211112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.29029550.326335068410.3738579350.0003884069960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInhibitor of nuclear factor kappa B kinase epsilon subunitHomo sapiens9.0416462467.1249387377.961112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.270579030.30818116714.84698679350.0002148824460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 16Homo sapiens9.0416462467.1249387377.721112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2767285530.31422374650.89397077350.0002796186660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YReceptor-interacting serine/threonine-protein kinase 4Homo sapiens9.0416462467.1249387377.891112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2801360990.318491283115.2432311350.000405864101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 11Homo sapiens9.0416462467.1249387377.241112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2946489430.331145171441.8967398350.00044388111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase 10Homo sapiens9.0416462467.1249387378.241112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2965694680.332620012562.8802929350.000451507111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase RIO1Homo sapiens9.0416462467.1249387378.051112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2853135310.323450109180.1133685350.00043561111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInterleukin-1 receptor-associated kinase 4Homo sapiens9.0416462467.1249387378.771111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2789609550.31598501740.05912612350.0002776996660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 11Homo sapiens9.0416462467.1249387377.741113ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2849373760.3230741691877.010244350.000507626111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YBone morphogenetic protein receptor type-1BHomo sapiens9.0416462467.1249387377.241112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2853135310.323450109180.1133685350.00043561111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YAMP-activated protein kinase- alpha-1 subunitHomo sapiens9.0416462467.1249387377.61112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.270579030.30818116714.84698679350.0002148824460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YInterleukin-1 receptor-associated kinase 3Homo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2850313220.323459748213.7973798350.000469024121260.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737Yc-Jun N-terminal kinase 3Homo sapiens9.0416462467.1249387377.921112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2877829560.324551764328.3510498350.000418485101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YPhosphorylase kinase gamma subunit 2Homo sapiens9.0416462467.1249387378.771112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2876871880.323587816237.8285647350.0003199327760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProto-oncogene tyrosine-protein kinase ROSHomo sapiens9.0416462467.1249387377.591112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2721120550.310147622439.7824862350.0003027796660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YCyclin-dependent kinase 4Homo sapiens9.0416462467.1249387377.491112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.32230301134.4552989350.0003723169960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YG protein-coupled receptor kinase 7Homo sapiens9.0416462467.1249387378.141112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2944482290.330374012362.0942014350.0003800469960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PAK 2Homo sapiens9.0416462467.1249387377.371112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2946489430.331145171430.6347858350.000443546111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMyosin light chain kinase- smooth muscleHomo sapiens9.0416462467.1249387377.91113ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2949505290.331203008436.7124059350.000412424101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase LATS2Homo sapiens9.0416462467.12493873791112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.32268859149.0102443350.00040313101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PAK 1Homo sapiens9.0416462467.1249387377.521112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2700718530.3072075793.096295107350.0001825033360.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase ICKHomo sapiens9.0416462467.1249387377.411112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2796829510.31772976487.3417866350.0003716389960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSPS1/STE20-related protein kinase YSK4Homo sapiens9.0416462467.1249387379.281112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.28559630.324606847534.4683177350.000543908141460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase SRPK1Homo sapiens9.0416462467.12493873781112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2778849240.31592580486.5935607350.0003113637760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProtein kinase N2Homo sapiens9.0416462467.1249387378.741112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2903930130.326412184311.7862131350.0003515938860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YProtein kinase N1Homo sapiens9.0416462467.1249387378.281112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.32230301134.4552989350.0003723169960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase JAK3Homo sapiens9.0416462467.1249387378.641112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2711731490.30908727944.53049134350.000280696660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YPlatelet-derived growth factor receptor betaHomo sapiens9.0416462467.1249387377.5451112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2832568810.322508194516.7195661350.000513462131360.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase MST1Homo sapiens9.0416462467.1249387378.521112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2895177490.325236167264.7620101350.0003197267760.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YPhosphorylase kinase gamma subunit 1Homo sapiens9.0416462467.1249387379.411112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2773500160.31555399588.18107863350.0003442018860.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNeurotrophic tyrosine kinase receptor type 2Homo sapiens9.0416462467.1249387377.851112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2761098690.31385331576.84935367350.000280356660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737Y3-phosphoinositide dependent protein kinase-1Homo sapiens9.0416462467.1249387378.471112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2889371660.325646534856.3985376350.000440522101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase SRPK3Homo sapiens9.0416462467.1249387377.891112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.322235534122.7797102350.0003724189960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YAnkyrin repeat and protein kinase domain-containing protein 1Homo sapiens9.0416462467.1249387377.491112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.322621113138.7978904350.000403232101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YPhosphatidylinositol-4-phosphate 5-kinase type-1 alphaHomo sapiens9.0416462467.1249387377.441112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2847496710.32230301134.4552989350.0003723169960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTyrosine-protein kinase ZAP-70Homo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2869233320.324838194315.3645967350.000440173111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase PCTAIRE-1Homo sapiens9.0416462467.1249387377.571112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2771721710.315910656365.3534703350.00041824101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YNUAK family SNF1-like kinase 1Homo sapiens9.0416462467.1249387378.431112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2949505290.331203008436.7124059350.000412424101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase Sgk3Homo sapiens9.0416462467.1249387378.241111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2793214860.31728634872.00994757350.000371829960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase Aurora-BHomo sapiens9.0416462467.1249387377.81112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor60.2954545450.3316657031435.893954350.000502287111160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YSerine/threonine-protein kinase MST2Homo sapiens9.0416462467.1249387378.621112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2874958430.324576551352.9138976350.000415791101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YcGMP-dependent protein kinase 2Homo sapiens9.0416462467.1249387377.61112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.271599120.30986807730.63374213350.0002793096660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YDual specificity mitogen-activated protein kinase kinase 5Homo sapiens9.0416462467.1249387378.151111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2801360990.319590184282.7777954350.000541349141460.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMyosin light chain kinaseHomo sapiens9.0416462467.1249387377.921111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2800453510.318105704100.3984651350.0003733049960.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YMitogen-activated protein kinase kinase kinase 9Homo sapiens9.0416462467.1249387378.461112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2848434930.322621113138.7978904350.000403232101060.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YLeucine-rich repeat serine/threonine-protein kinase 2Homo sapiens9.0416462467.1249387378.521112ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.272455090.31059103838.89348917350.0002792296660.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YReceptor-type tyrosine-protein kinase FLT3Mus musculus5.7083129127.1249387378.82010.51ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2668209880.3035115260350.0001168361160.3638468010.483227299153769.6325350.015110063388388
LESTAURTINIBactual7.124938737YTankyrase-2Homo sapiens9.0416462467.1249387378.181111ACUTE MYELOID LEUKEMIA, LEUKEMIA, PSORIASISNT-3 growth factor receptor inhibitor, Nerve growth factor receptor Trk-A inhibitor, Neurotrophic tyrosine kinase receptor type 2 inhibitor, Tyrosine-protein kinase JAK2 inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor RET inhibitor70.2673160170.3044851145.537972698350.0001492142260.3638468010.483227299153769.6325350.015110063388388
MIDOSTAURINpredictedProtein kinase N1Homo sapiens7.4575000052.3725000158.031113ACUTE MYELOID LEUKEMIA, LEUKEMIA, LIVER DISEASEPlatelet-derived growth factor receptor inhibitor, Protein kinase C (PKC) inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor 2 inhibitor70.2847496710.32230301134.4552989350.0003723169970.2643730890.34398358514122.31028350.007611746200200
MIDOSTAURINpredictedSPS1/STE20-related protein kinase YSK4Homo sapiens7.7104213053.1312639167.821112ACUTE MYELOID LEUKEMIA, LEUKEMIA, LIVER DISEASEPlatelet-derived growth factor receptor inhibitor, Protein kinase C (PKC) inhibitor, Stem cell growth factor receptor inhibitor, Tyrosine-protein kinase receptor FLT3 inhibitor, Vascular endothelial growth factor receptor 2 inhibitor70.28559630.324606847534.4683177350.000543908141470.2643730890.34398358514122.31028350.007611746200200
LINSITINIBpredictedInsulin-like growth factor I receptorHomo sapiens8.0614285144.1842855437.9151116ADRENOCORTICAL CARCINOMA, HEPATOCELLULAR CARCINOMA, NEOPLASM, OVARIAN CARCINOMA, PROSTATE ADENOCARCINOMA, SMALL CELL LUNG CARCINOMAInsulin receptor inhibitor, Insulin-like growth factor I receptor inhibitor70.28521940.320672561967.5190036350.000303565580.2221223020.2381661570.403225806350.000190422
LINSITINIBpredictedInsulin receptorHomo sapiens8.0270543684.0811631057.741111ADRENOCORTICAL CARCINOMA, HEPATOCELLULAR CARCINOMA, NEOPLASM, OVARIAN CARCINOMA, PROSTATE ADENOCARCINOMA, SMALL CELL LUNG CARCINOMAInsulin receptor inhibitor, Insulin-like growth factor I receptor inhibitor70.2854077250.3214437192745.943338350.0004541487780.2221223020.2381661570.403225806350.000190422
SCOPOLAMINEpredictedMuscarinic acetylcholine receptor M1Bos taurus7.5208333232.562499979.391111ANXIETY, NAUSEAMuscarinic acetylcholine receptor M1 antagonist60.2888406280.3174667449434.89423600.001795345313170.2265461220.24101049324.80880500.00037960166
SCOPOLAMINEpredictedMuscarinic acetylcholine receptor M4Homo sapiens7.5208333232.562499977.7369525781115ANXIETY, NAUSEAMuscarinic acetylcholine receptor M1 antagonist60.2801360990.3036630042650.8432300.001281184232370.2265461220.24101049324.80880500.00037960166
SCOPOLAMINEpredictedMuscarinic acetylcholine receptor M3Homo sapiens7.5208333232.562499978.191111ANXIETY, NAUSEAMuscarinic acetylcholine receptor M1 antagonist60.2804996760.3043474073029.8775800.001343026242470.2265461220.24101049324.80880500.00037960166
ASIMADOLINEpredictedKappa opioid receptorHomo sapiens7.7179653773.153896139.31111IRRITABLE BOWEL SYNDROMEunknown70.284655910.3078713274741.60767600.00108945161680.2216098440.231410256000.00014156811
VANCOMYCIN HYDROCHLORIDEpredictedSolute carrier organic anion transporter family member 1B1Homo sapiens8.4965899335.48976989.0077162881111CYSTIC FIBROSIS, INFECTIONPeptidoglycan inhibitor60.3382237870.395430885160170.35530.00966758511311370.2550147490.275624501126.191630440.0002341322
METHADONE HYDROCHLORIDEactual6.781464495YOpioid receptorRattus norvegicus8.9271548325.5860983717.291113SCOLIOSISMu opioid receptor agonist80.2188053660.22890949918.0998426400.0002716962270.2653468390.2837092731036.85690700.00026173722
METHADONE HYDROCHLORIDEactual6.781464495YOpioid receptorRattus norvegicus8.9271548325.5860983717.291111SCOLIOSISMu opioid receptor agonist80.2188053660.22890949918.0998426400.0002716962270.2653468390.2837092731036.85690700.00026173722
LANREOTIDEpredictedSomatostatin receptor 2Homo sapiens8.3128449964.9385349899.31111CARCINOID TUMOR, COLORECTAL ADENOCARCINOMA, DIARRHEA, GROWTH HORMONE EXCESS, KIDNEY DISEASE, NEOPLASMunknown80.1827309240.18935181431.27369292370.0003412692290.1914728680.199627273117.6185678370.00048490733
LANREOTIDEpredictedSomatostatin receptor 5Homo sapiens8.3128449964.9385349898.41111CARCINOID TUMOR, COLORECTAL ADENOCARCINOMA, DIARRHEA, GROWTH HORMONE EXCESS, KIDNEY DISEASE, NEOPLASMunknown80.2366548040.2514252662145.579483370.0003923433390.1914728680.199627273117.6185678370.00048490733
MARAVIROCpredictedC-C chemokine receptor type 5Macaca mulatta7.7574006943.2722020819.621111ACUTE GRAFT VS. HOST DISEASE, AIDS, AIDS DEMENTIA, HIV INFECTION, HIV-1 INFECTION, HYPERTRIGLYCERIDEMIA, INFECTION, RHEUMATOID ARTHRITIS, VIRAL DISEASEC-C chemokine receptor type 5 antagonist70.2369142230.248726211345500.0005372523380.1915577220.197616982000.00023591311
INSULIN HUMANpredictedInsulin receptorRattus norvegicus8.4694208225.4082624658.7251112BIPOLAR DISORDER, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, COLORECTAL ADENOCARCINOMA, DIABETES MELLITUS, GESTATIONAL DIABETES, HYPERGLYCEMIA, HYPOGLYCEMIA, HYPOGONADOTROPHIC HYPOGONADISM, INSULIN RESISTANCE, MYOCARDIAL INFARCTION, NICOTINE DEPENDENCE, NON-ALCOHOLIC FATTY LIVER DISEASE, OBESITY, SCHIZOPHRENIA, SUBARACHNOID HEMORRHAGE, TYPE I DIABETES MELLITUS, TYPE II DIABETES MELLITUS, UNIPOLAR DEPRESSIONInsulin receptor agonist70.2854077250.3214437192745.943338350.0004541487780.2220652450.2377805780350.00013882311
ROMIDEPSINpredictedHistone deacetylase 3/NCoR1Homo sapiens7.64125552.9237664999.821111ACUTE PROMYELOCYTIC LEUKEMIA, COLORECTAL ADENOCARCINOMA, CUTANEOUS T-CELL LYMPHOMA, HIV INFECTION, LYMPHOMA, MALE BREAST CARCINOMA, MULTIPLE MYELOMA, NEOPLASM, PROSTATE CARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, UNSPECIFIED PERIPHERAL T-CELL LYMPHOMAHistone deacetylase inhibitor80.2337118140.24635421131.897435550.0002927332280.2140911340.230214272150.547502650.00075121166
ROMIDEPSINpredictedHistone deacetylase 3/NCoR1Homo sapiens7.64125552.9237664999.821111ACUTE PROMYELOCYTIC LEUKEMIA, COLORECTAL ADENOCARCINOMA, CUTANEOUS T-CELL LYMPHOMA, HIV INFECTION, LYMPHOMA, MALE BREAST CARCINOMA, MULTIPLE MYELOMA, NEOPLASM, PROSTATE CARCINOMA, RENAL CELL CARCINOMA, SMALL CELL LUNG CARCINOMA, UNSPECIFIED PERIPHERAL T-CELL LYMPHOMAHistone deacetylase inhibitor80.2337118140.24635421131.897435550.0002927332280.2140911340.230214272150.547502650.00075121166
OMIPALISIBpredictedMammalian target of Rapamycin (mTORC1)Homo sapiens7.8581095623.5743286879.741111IDIOPATHIC PULMONARY FIBROSIS, NEOPLASMPI3-kinase class I inhibitor, Serine/threonine-protein kinase mTOR inhibitor80.2173749060.2459493511736.980676350.0003128113390.1785788060.1925459250350.00017230611
OMIPALISIBpredictedMammalian target of Rapamycin (mTORC1)Homo sapiens7.8581095623.5743286879.741111IDIOPATHIC PULMONARY FIBROSIS, NEOPLASMPI3-kinase class I inhibitor, Serine/threonine-protein kinase mTOR inhibitor80.2173749060.2459493511736.980676350.0003128113390.1785788060.1925459250350.00017230611
FIPAMEZOLEpredictedAlpha-2a adrenergic receptorHomo sapiens7.6808420593.0425261768.141111PARKINSON'S DISEASEunknown60.2873047520.3163967619934.04679400.002098773363670.2257180160.2387631172.19754048100.00022631533
FIPAMEZOLEpredictedAlpha-2c adrenergic receptorHomo sapiens7.33333333327.861111PARKINSON'S DISEASEunknown60.2793214860.3025448242596.31627100.001323976242470.2257180160.2387631172.19754048100.00022631533
TIVOZANIBpredictedVascular endothelial growth factor receptor 3Homo sapiens7.7684550513.3053651529.0651112COLORECTAL ADENOCARCINOMA, GLIOBLASTOMA MULTIFORME, HEPATOCELLULAR CARCINOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, RENAL CELL CARCINOMA, SARCOMAVascular endothelial growth factor receptor inhibitor70.2916666670.3291456661284.365223350.000541215131380.2270220590.2436647949.200235002350.00021848533
ALISPORIVIRpredictedCyclophilin AHomo sapiens8.0338750644.1016251937.8120170391114CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, HEPATITIS C INFECTION, LIVER DISEASEunknown80.2299202130.2407219975.35992088830.0002501492270.2588323350.2813062881207.45208230.00051638555
ALISPORIVIRpredictedCyclophilin BHomo sapiens8.0435256044.13057681291111CHRONIC HEPATITIS C INFECTION, CHRONIC KIDNEY DISEASE, HEPATITIS C INFECTION, LIVER DISEASEunknown80.2299202130.2407219975.35992088830.0002501492270.2588323350.2813062881207.45208230.00051638555
ALECTINIBpredictedALK tyrosine kinase receptorHomo sapiens7.5442751142.6328253438.721111LIVER DISEASE, NON-SMALL CELL LUNG CARCINOMAunknown70.2714285710.309646369368.2221356350.0003224176670.2332074450.250159745.036206023350.00020393233
RelugolixpredictedGonadotropin-releasing hormone receptorRattus norvegicus7.7626946143.2880838439.491112ENDOMETRIOSIS, PROSTATE CARCINOMA, UTERINE FIBROIDGonadotropin-releasing hormone receptor antagonist80.2262496730.240171176906170.0010404285590.184525080.1917210610170.00026056811
SELEPRESSINpredictedVasopressin V1a receptorHomo sapiens7.5861156362.7583469078.621112SEPTIC SHOCKVasopressin V1a receptor agonist70.2457362140.2577418823265.00288370.0007049226680.2013274340.20790299911.8130408770.00029778122
SELEPRESSINpredictedVasopressin V1a receptorRattus norvegicus7.5861156362.7583469079.261112SEPTIC SHOCKVasopressin V1a receptor agonist70.2457362140.2577418823265.00288370.0007049226680.2013274340.20790299911.8130408770.00029778122
SOMATOSTATINpredictedMu opioid receptorRattus norvegicus8.7031321376.1093964118.221111CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown70.2829787230.30628081210082.8795500.00121941171770.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 2Mus musculus8.4965899335.48976989.551111CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.1827309240.18935181431.27369292370.0003412692270.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 3Mus musculus8.4965899335.489769810.11111CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.1827309240.18935181431.27369292370.0003412692270.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 5Rattus norvegicus8.4965899335.48976989.071111CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.2366548040.2514252662145.579483370.0003923433370.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 2Homo sapiens8.4931717055.4795151149.91968307811113CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.1827309240.18935181431.27369292370.0003412692270.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 3Homo sapiens8.4966909755.4900729268.81833333311112CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.1827309240.18935181431.27369292370.0003412692270.2235005170.2361659648637.526673370.00113077888
SOMATOSTATINpredictedSomatostatin receptor 5Homo sapiens8.5180404955.5541214869.12221048711118CIRRHOSIS OF LIVER, GASTRIC CARCINOMA, KIDNEY DISEASE, PROSTATE ADENOCARCINOMAunknown80.2366548040.2514252662145.579483370.0003923433370.2235005170.2361659648637.526673370.00113077888
IBRUTINIBpredictedTyrosine-protein kinase BMXHomo sapiens7.6634516082.9903548259.11111ACUTE GRAFT VS. HOST DISEASE, ACUTE MYELOID LEUKEMIA, CARCINOID TUMOR, CHRONIC LYMPHOCYTIC LEUKEMIA, HODGKINS LYMPHOMA, LEUKEMIA, LIVER DISEASE, LUNG CARCINOMA, LYMPHOID LEUKEMIA, LYMPHOMA, MACROGLOBULINEMIA, MANTLE CELL LYMPHOMA, MULTIPLE MYELOMA, NEOPLASM, NEOPLASM OF MATURE B-CELLS, NON-HODGKINS LYMPHOMA, PROSTATE CARCINOMA, T-CELL ACUTE LYMPHOBLASTIC LEUKEMIATyrosine-protein kinase BTK inhibitor60.2887441550.324416811381.6415807350.000334327770.2473533620.26428158339.08774635350.00028594855
IVACAFTORpredictedCystic fibrosis transmembrane conductance regulatorHomo sapiens7.5777543562.7332630677.5921115CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CYSTIC FIBROSISCystic fibrosis transmembrane conductance regulator positive modulator1111400.0008142292220.6666666670.750400.00042993911
EVACETRAPIBpredictedCholesteryl ester transfer proteinHomo sapiens7.5579043572.673713077.591111CARDIOVASCULAR DISEASE, DISORDER OF LIPID METABOLISM, HYPERCHOLESTEROLEMIAunknown1110390.000558036111110390.00055803611
CARIPRAZINE HYDROCHLORIDEpredictedDopamine D3 receptorRattus norvegicus7.7949007173.3847021528.81111BIPOLAR DISORDER, SCHIZOPHRENIADopamine D2 receptor modulator, Dopamine D3 receptor modulator60.289614740.3209465979204.65765900.002356341424270.2291280150.244319598.07508083700.00023295133
CARIPRAZINE HYDROCHLORIDEpredictedDopamine D2 receptorRattus norvegicus7.8458445253.5375335747.81111BIPOLAR DISORDER, SCHIZOPHRENIADopamine D2 receptor modulator, Dopamine D3 receptor modulator60.28559630.3141218439635.28533700.002095645353570.2291280150.244319598.07508083700.00023295133
CARIPRAZINE HYDROCHLORIDEpredictedDopamine D3 receptorHomo sapiens7.7949007173.38470215210.051111BIPOLAR DISORDER, SCHIZOPHRENIADopamine D2 receptor modulator, Dopamine D3 receptor modulator60.289614740.3209465979204.65765900.002356341424270.2291280150.244319598.07508083700.00023295133
CARIPRAZINE HYDROCHLORIDEpredictedDopamine D2 receptorHomo sapiens7.7949007173.3847021528.6651112BIPOLAR DISORDER, SCHIZOPHRENIADopamine D2 receptor modulator, Dopamine D3 receptor modulator60.28559630.3141218439635.28533700.002095645353570.2291280150.244319598.07508083700.00023295133
CARIPRAZINEpredictedSerotonin 2a (5-HT2a) receptorHomo sapiens8.0928230654.2784691967.661111BIPOLAR DISORDER, PSYCHOSIS, SCHIZOPHRENIA, UNIPOLAR DEPRESSIONunknown60.3051535470.34117023314148.5294300.002040502363670.2426326130.2600498512.6260545600.00023023533
BREMELANOTIDEpredictedMelanocortin receptor 5Homo sapiens8.1852377984.5557133937.771111SEXUAL DYSFUNCTIONMelanocortin receptor 1 agonist, Melanocortin receptor 3 agonist, Melanocortin receptor 4 agonist70.2554669030.2702635711109.93208900.0003093733380.2115243450.2196528411729.65437300.00042378633
BREMELANOTIDEpredictedMelanocortin receptor 4Homo sapiens7.8965639713.6896919149.651112SEXUAL DYSFUNCTIONMelanocortin receptor 1 agonist, Melanocortin receptor 3 agonist, Melanocortin receptor 4 agonist70.2680620160.2843317084202.4878900.0005593776680.2115243450.2196528411729.65437300.00042378633
COSYNTROPINpredictedMelanocortin receptor 4Homo sapiens8.522783965.5683518819.191111ADRENAL GLAND DISEASEMelanocortin receptor 2 agonist70.2680620160.2843317084202.4878900.0005593776680.2114208850.218881682000.00016293511
GANETESPIBpredictedHeat shock protein HSP 90-alphaHomo sapiens7.5354221952.6062665848.31111BREAST CARCINOMA, COLORECTAL ADENOCARCINOMA, GASTROINTESTINAL STROMAL TUMOR, HEPATOCELLULAR CARCINOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, SMALL CELL LUNG CARCINOMAunknown70.2662457650.2847765022327.47030240.0006150117780.2103406330.21914332538.9269167540.00027686422
GANETESPIBpredictedHeat shock protein HSP 90-betaHomo sapiens7.5354221952.6062665848.31111BREAST CARCINOMA, COLORECTAL ADENOCARCINOMA, GASTROINTESTINAL STROMAL TUMOR, HEPATOCELLULAR CARCINOMA, MALIGNANT PLEURAL MESOTHELIOMA, MELANOMA, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, SMALL CELL LUNG CARCINOMAunknown80.2325800380.243478201182.909036840.0002788472280.2103406330.21914332538.9269167540.00027686422
CERLAPIRDINEpredictedSerotonin 6 (5-HT6) receptorHomo sapiens8.033371324.1001139618.891111ALZHEIMERS DISEASESerotonin 6 (5-HT6) receptor antagonist60.3062345020.339917112310.5040400.001709791282870.2344724710.247945413000.00013559511
ORVEPITANTpredictedSubstance-P receptorMeriones unguiculatus7.5437554872.63126646210.51111POST-TRAUMATIC STRESS DISORDER, UNIPOLAR DEPRESSIONNeurokinin 1 receptor antagonist20.6666666670.750410.000429939111111410.00081422922
COBIMETINIBpredictedDual specificity mitogen-activated protein kinase kinase 1Homo sapiens7.4677111332.4031333988.7151112ACUTE MYELOID LEUKEMIA, NEOPLASMDual specificity mitogen-activated protein kinase kinase 1 inhibitor, Dual specificity mitogen-activated protein kinase kinase 2 inhibitor60.2901980530.3267399272976.33696350.000533093101070.2249544630.2406648490350.0001289911
IDALOPIRDINEpredictedSerotonin 6 (5-HT6) receptorHomo sapiens8.0243359054.0730077149.081113ALZHEIMERS DISEASESerotonin 6 (5-HT6) receptor antagonist60.3062345020.339917112310.5040400.001709791282870.2344724710.247945413000.00013559511
GILTERITINIBpredictedTyrosine-protein kinase receptor FLT3Homo sapiens7.7210277843.1630833519.391111ACUTE MYELOID LEUKEMIA, LIVER DISEASE, NEOPLASMTyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor UFO inhibitor70.2761098690.3160098051180.098712350.000588806141480.2228092780.2409588531.086947243350.00019729433
GILTERITINIBpredictedTyrosine-protein kinase receptor RETHomo sapiens7.5562554642.6687663918.471111ACUTE MYELOID LEUKEMIA, LIVER DISEASE, NEOPLASMTyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor UFO inhibitor70.2838148390.3245806822421.142611350.00074186181880.2228092780.2409588531.086947243350.00019729433
GILTERITINIBpredictedProto-oncogene tyrosine-protein kinase ROSHomo sapiens7.5562554642.6687663918.721111ACUTE MYELOID LEUKEMIA, LIVER DISEASE, NEOPLASMTyrosine-protein kinase receptor FLT3 inhibitor, Tyrosine-protein kinase receptor UFO inhibitor70.2721120550.310147622439.7824862350.0003027796680.2228092780.2409588531.086947243350.00019729433
TIOTROPIUM BROMIDEpredictedMuscarinic acetylcholine receptor M2Rattus norvegicus7.5124999892.5374999679.821111ASTHMA, CHRONIC BRONCHITIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CYSTIC FIBROSIS, EMPHYSEMA, OBSTRUCTIVE LUNG DISEASEMuscarinic acetylcholine receptor M3 antagonist60.2791411040.3018218622744.82981500.001203924212170.2255413510.2391789918.21180051500.00032440755
DOCETAXEL HYDRATEactual8.472693473YGrowth hormone-releasing hormone receptorHomo sapiens9.4908978248.4726934739.851111BLADDER CARCINOMA, BREAST CARCINOMA, BREAST NEOPLASM, CANCER, CARCINOMA, ESOPHAGEAL CARCINOMA, GASTRIC ADENOCARCINOMA, GASTRIC CARCINOMA, HEAD AND NECK SQUAMOUS CELL CARCINOMA, LEUKEMIA, LUNG CARCINOMA, NASOPHARYNGEAL NEOPLASM, NEOPLASM, NON-SMALL CELL LUNG CARCINOMA, OVARIAN CARCINOMA, PANCREATIC CARCINOMA, PROSTATE ADENOCARCINOMA, PROSTATE CARCINOMA, SQUAMOUS CELL CARCINOMA, SQUAMOUS CELL LUNG CARCINOMA, STOMACH NEOPLASM, UPPER AERODIGESTIVE TRACT NEOPLASMTubulin inhibitor80.2008596650.209152689030.0001716951170.251308140.2680423591781.07151230.0004139944
Table contains the actual and predicted scores for P53 drug-target pairs.

Using graphs to monitor target relevance and drugs specificity.

Data can be re-shaped in a graph mode so that we can explore the relationships with molecules and targets. By calculating centrality measures we can better understand the importance of protein nodes and the promiscuity of drug nodes. The graph below shows all drug-target identified relations. It is interesting to see how the graph clearly identifies a non specific promiscuous kinase inhibitors cluster with big drug nodes (lestaurtinib, selumetinib, enzastaurin and others) connecting with many protein targets.

All relevant drug-target relations sized by degree.

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Now we can query the graph by centrality cut-off centrality (left), exclude targets containing only actual records (middle) or select only targets that have only predicted records (right).

Selection of higher degree nodes.

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In this graph, protein nodes lacking of predicted values have been removed.

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Selection of targets interacting only with drugs with predicted activity.

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Relationships can also be clustered to detect populations. The graph below shows the four main modules detected by modularity classification.

  • Module 35 corresponds to kinases targets related to promiscuous kinase inhibitors.
  • Module 5 is enriched in nuclear receptors.
  • Module 0 is basically made up by classic GPCR targets and their drugs.
  • Module 3 has a strong component of transporters.

P53 drug-targets graph segmentation.

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Each cluster can be analyzed separately with an individualized layout.

 

Module 35: Kinases and promiscuous kinase inhibitors.

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Module 4: Nuclear receptors enriched fraction.

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Module 0: GPCR drugs and targets.

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Module 3: transporters.

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Now we can use degree or any other centrality measure to select potent targets with many interactions with drugs with few interactions. The two charts below show targets interacting with more than 6 molecules (up to 147), but each of these molecules having less than 5 positive records of positive interaction. There is one chart for each, actual or predicted P53 scores.

 

Drugs with good actual P53 potency and centrality measures for target and molecule.

 

 

Drugs with good predicted P53 potency and centrality measures for target and molecule.

 

 

And we can use a treemap to check how the drugs and their actual or predicted P53 potency fit in the respective clinical pipelines…

Drugs for repurposing from actual P53 scores.

 

Drugs for repurposing from predicted P53 scores.

 

 

Drug-target interactions filtered by centrality measures.

molNameproteinNameCorganismCkindOfValuep53ActivityScoreActualp53ActiveActualavgPredIndexAvgPrediction80RFRegressionAvgChemblActivityScoreCcountRatioRpartcountRatioRFcountRatioAvgRpartRFCountChemblActivityScoreCdegreeProteindegreeMolName
ALECTINIBALK tyrosine kinase receptorHomo sapienspredicted7.5442751142.6328253438.72111163
BREMELANOTIDEMelanocortin receptor 4Homo sapienspredicted7.8965639713.6896919149.65111263
COSYNTROPINMelanocortin receptor 4Homo sapienspredicted8.522783965.5683518819.19111161
DOCETAXEL HYDRATETubulinBos taurusactual8.472693473Y9.4908978248.4726934735.951771244111964
GILTERITINIBProto-oncogene tyrosine-protein kinase ROSHomo sapienspredicted7.5562554642.6687663918.72111163
PANOBINOSTATHistone deacetylasePlasmodium falciparumpredicted7.6965295983.0895887938.74111162
SELEPRESSINVasopressin V1a receptorHomo sapienspredicted7.5861156362.7583469078.62111262
SELEPRESSINVasopressin V1a receptorRattus norvegicuspredicted7.5861156362.7583469079.26111262
TOLVAPTANVasopressin V2 receptorHomo sapienspredicted7.5437554872.6312664629.37111161
VASOPRESSINVasopressin V2 receptorSus scrofapredicted8.3128449964.9385349898.48111164
VASOPRESSINVasopressin V2 receptorRattus norvegicuspredicted8.0353243134.1059729399.221616674111364
VASOPRESSINVasopressin V2 receptorBos tauruspredicted8.2070123074.6210369218.82111164
VASOPRESSINVasopressin V1a receptorRattus norvegicuspredicted8.0009867144.0029601439.508111564
VASOPRESSINVasopressin V2 receptorHomo sapienspredicted7.997627363.992882089.328622445111964
VASOPRESSINVasopressin V1a receptorHomo sapienspredicted7.8642915354.3071603198.65785714310.9285714290.9642857141464
GANETESPIBHeat shock protein HSP 90-alphaHomo sapienspredicted7.5354221952.6062665848.3111172
INSULIN HUMANInsulin receptorRattus norvegicuspredicted8.4694208225.4082624658.725111271
LASOFOXIFENEEstrogen receptor betaHomo sapienspredicted8.2395866684.7187600038.2475111473
TORSEMIDETAR DNA-binding protein 43Homo sapiensactual5.244666445Y5.0815554823.6223332226.250031916010.5184
IRBESARTANAngiotensin II receptorHomo sapienspredicted7.8808397573.6425192728.52111293
LOSARTAN POTASSIUMAngiotensin II receptorHomo sapienspredicted8.1280410944.3841232818.52111292
NILVADIPINEVoltage-gated L-type calcium channelRattus norvegicuspredicted7.8483223293.5449669878.98111391
TASOSARTANAngiotensin II receptorHomo sapienspredicted7.6183399732.8550199188.4111292
COBIMETINIBDual specificity mitogen-activated protein kinase kinase 1Homo sapienspredicted7.4677111332.4031333988.7151112101
DONEPEZIL HYDROCHLORIDEAcetylcholinesteraseTorpedo californicapredicted7.5729221342.7187664028.241111121
NORETHINDRONEEstrogen receptorRattus norvegicuspredicted7.7937554743.3812664229.21111124
TIVOZANIBVascular endothelial growth factor receptor 3Homo sapienspredicted7.7684550513.3053651529.0651112133
GILTERITINIBTyrosine-protein kinase receptor FLT3Homo sapienspredicted7.7210277843.1630833519.391111143
DEXMEDETOMIDINEAdrenergic receptor alpha-2Rattus norvegicuspredicted7.5437554872.63126646210.821113154
DOCETAXEL HYDRATENeurokinin 2 receptorHomo sapiensactual8.472693473Y9.4908978248.4726934736.0451112154
ASIMADOLINEKappa opioid receptorHomo sapienspredicted7.7179653773.153896139.31111161
ALFENTANIL HYDROCHLORIDEMu opioid receptorHomo sapiensactual6.622147581Y2.2073825274.311073796.110001171
ROPINIROLEDopamine D4 receptorHomo sapienspredicted7.33333333328.111111174
GILTERITINIBTyrosine-protein kinase receptor RETHomo sapienspredicted7.5562554642.6687663918.471111183
ROSIGLITAZONE MALEATEPeroxisome proliferator-activated receptor gammaHomo sapiensactual5.61640004Y8.5388000134.8750656066.9533333331113183
TORSEMIDEDNA-(apurinic or apyrimidinic site) lyaseHomo sapiensactual5.244666445Y5.0815554824.7934998628.102372909010.51184
TRIFLUPERIDOLSigma opioid receptorHomo sapienspredicted7.7625110393.2875331169.081111183
TRIFLUPERIDOLSigma opioid receptorRattus norvegicuspredicted7.7625110393.2875331169.11111183
DEXMEDETOMIDINEAdrenergic receptor alpha-1Rattus norvegicuspredicted7.7500109383.2500328138.31113204
NORETHINDRONEProgesterone receptorBos tauruspredicted8.1322581514.3967744528.471112214
TARANABANTCytochrome P450 2D6Homo sapienspredicted7.7910486423.3731459279.231111224
DECITABINEATPase family AAA domain-containing protein 5Homo sapiensactual6.625068446Y5.5416894825.2164648156.236422276010.51262
CERLAPIRDINESerotonin 6 (5-HT6) receptorHomo sapienspredicted8.033371324.1001139618.891111281
IDALOPIRDINESerotonin 6 (5-HT6) receptorHomo sapienspredicted8.0243359054.0730077149.081113281
TARANABANTCytochrome P450 2C9Homo sapienspredicted7.7910486423.3731459279.031111284
CINCHOPHENGlucocorticoid receptorHomo sapiensactual5.863755198Y8.6212517333.9318775997.8507808871111303
CARIPRAZINE HYDROCHLORIDEDopamine D2 receptorHomo sapienspredicted7.7949007173.3847021528.6651112353
CLOTHIAPINEDopamine D2 receptorHomo sapienspredicted7.33333333329.311111353
ECOPIPAMDopamine D2 receptorHomo sapiensactual5.925073903Y8.6416913015.9250739036.011112354
ECOPIPAMDopamine D2 receptorRattus norvegicusactual5.925073903Y8.6416913015.3339940846.291111354
CABERGOLINESerotonin 2b (5-HT2b) receptorHomo sapiensactual5.525070214Y6.8416900713.5190127178.3710.50.752381
HYDROFLUMETHIAZIDENuclear factor NF-kappa-B p105 subunitHomo sapiensactual5.644663438Y8.5482211465.3993382687.2716462181111384
HYDROFLUMETHIAZIDENuclear factor NF-kappa-B p105 subunitHomo sapiensactual5.644663438Y8.5482211465.3993382687.2716462181111384
ECOPIPAMDopamine D1 receptorRattus norvegicusactual5.925073903Y8.6416913015.1563033528.721111394
ECOPIPAMDopamine D1 receptorHomo sapiensactual5.925073903Y8.6416913015.8344483728.821114394
CARIPRAZINE HYDROCHLORIDEDopamine D3 receptorRattus norvegicuspredicted7.7949007173.3847021528.81111423
CARIPRAZINE HYDROCHLORIDEDopamine D3 receptorHomo sapienspredicted7.7949007173.38470215210.051111423
VINORELBIN DITARTRATEProto-oncogene c-JUNHomo sapiensactual6.97510404Y8.9917013477.0517509656.9714287471111453
HYDROFLUMETHIAZIDEPrelamin-A/CHomo sapiensactual5.644663438Y5.2148878134.5059430596010.51464
VINCAMINESolute carrier organic anion transporter family member 1B3Homo sapiensactual5.494407437Y5.1648024793.6626061595.902575883010.51593
CINCHOPHENPeroxisome proliferator-activated receptor deltaHomo sapiensactual5.863755198Y8.6212517334.6898470296.1771822041112683
MYCOPHENOLATE MOFETILPeroxisome proliferator-activated receptor deltaHomo sapiensactual6.97510404Y8.9917013475.6325728286.1251124891111683
DECITABINEGemininHomo sapiensactual6.625068446Y5.5416894825.2164648156.636200055010.51752
PHENSUXIMIDEGemininHomo sapiensactual6.225045311Y2.0750151043.320326666.886056648000175
CLOFARABINENuclear factor erythroid 2-related factor 2Homo sapiensactual7.075204004Y9.0250680015.8064030035.7751045291111821
MYCOPHENOLATE MOFETILNuclear factor erythroid 2-related factor 2Homo sapiensactual6.97510404Y8.9917013476.8105120375.975104041111823
VINORELBIN DITARTRATENuclear factor erythroid 2-related factor 2Homo sapiensactual6.97510404Y5.6583680133.243776016.525055665100.51823
VANCOMYCIN HYDROCHLORIDESolute carrier organic anion transporter family member 1B1Homo sapienspredicted8.4965899335.48976989.00771628811111132
ACIPIMOXAndrogen ReceptorHomo sapiensactual5.125066148Y8.3750220494.7185711826.17509352911111473
GEMCITABINE HYDROCHLORIDEAndrogen ReceptorHomo sapiensactual6.97510404Y5.6583680134.9517140936.221342368100.511471
LORAZEPAMAndrogen ReceptorHomo sapienspredicted7.5791666172.737499858.56863623611111471
MYCOPHENOLATE MOFETILAndrogen ReceptorHomo sapiensactual6.97510404Y8.9917013476.8825893346.17134010311111473
VINORELBIN DITARTRATEAndrogen ReceptorHomo sapiensactual6.97510404Y8.9917013477.0517509655.69634324811121473
Table contains the drug-target interactions with highest P53 potency scores (actual or predicted) with low degree molecules and high degree proteins.