SMN2: Targets involved in SMN2 expression

Selection of targets potentially involved in regulation of SMN2 expression.

In this section,  we use only compounds predicted as active in 100% of occasions by random forest binomial models. From this data set, actual and predicted activities described in SMN2 prediction of activity section are aggregated by molecular target, obtaining a scoreForSMN2 from SMN2 predictions and actual values average, and scoreForTaget from the averaged experimental scores for each target.

Plot below shows molecular target with the highest likelihood of  being involved in SMN2 expression.

 

Bar chart of the best scored molecular targets

 

Protein targets enhancers of SMN2 expression

shortNameuniprotOrganismscoreForTargetscoreForSMN2countOfMoleculesTotalEvents%ActualRecordsProtein namesGene names
Q6Q793Q6Q793Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))9.287.05110Neuraminidase (EC 3.2.1.18)NA
ACPMP52505Bos taurus (Bovine)8.9418391345.57403846213260Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)NDUFAB1
NDUV1P25708Bos taurus (Bovine)8.9418391345.57403846213260NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit)NDUFV1 UQOR1
MTORP42346Rattus norvegicus (Rat)8.7866666675.745833333330Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1)Mtor Frap1 Raft1
ADA1BP18841Mesocricetus auratus (Golden hamster)8.76.225110Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)ADRA1B
DYRP0A017Staphylococcus aureus8.586.1225220Dihydrofolate reductase (DHFR) (EC 1.5.1.3)folA
HEM6Q42840Hordeum vulgare (Barley)8.526.611439373110Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)CPX
MCHR1P97639Rattus norvegicus (Rat)8.3955.7120Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)Mchr1 Gpr24 Slc1
CSF1P07141Mus musculus (Mouse)8.3325757495.577166667560Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1]Csf1 Csfm
ADA17O77636Sus scrofa (Pig)7.975.82181818211110Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) (Fragment)ADAM17 TACE
CRFR2P47866Rattus norvegicus (Rat)7.9396.3037510380Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)Crhr2 Crf2r
SC5A5Q63008Rattus norvegicus (Rat)7.825.947916667220Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5)Slc5a5 Nis
AT2A1P04191Oryctolagus cuniculus (Rabbit)7.76.16875120Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)ATP2A1
Q46991Q46991Enterobacter cloacae7.555.8975110Beta-lactamase (EC 3.5.2.6)imiA blaIMI-1 imi-1 AW879_08570
DYRP16184Pneumocystis carinii7.295.883333333330Dihydrofolate reductase (EC 1.5.1.3)
ACM1P16395Drosophila melanogaster (Fruit fly)7.2898995256.1022916673533.33333333Muscarinic acetylcholine receptor DM1mAChR-A AcrC mAcR-60C CG4356
TM11DO60235Homo sapiens (Human)7.28255.915625440Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]TMPRSS11D HAT
ADA1DP97714Mus musculus (Mouse)76.0625130Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor)Adra1d Adra1a Gpcr8
ADA1AP97718Mus musculus (Mouse)76.0625130Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor)Adra1a Adra1c
ADA1BP97717Mus musculus (Mouse)76.0625130Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)Adra1b
SYI1P41972Staphylococcus aureus6.5166666676.4425330Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)ileS
CPT1AP50416Homo sapiens (Human)6.56.1110Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)CPT1A CPT1
NEPP19621Sus scrofa (Pig)6.377.15110Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) (Fragment)MME
PDE4DP14270Rattus norvegicus (Rat)6.283467166.0653906258470cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3)Pde4d
NRAMP03470Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))6.126.363888889340Neuraminidase (EC 3.2.1.18)NA
ECRP34021Drosophila melanogaster (Fruit fly)5.74256.1875440Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1)EcR NR1H1 CG1765
S22A7Q5RLM2Rattus norvegicus (Rat)5.747.311100Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2)Slc22a7 Nlt Oat2
ESYT1Q3U7R1Mus musculus (Mouse)57.3625140Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)Esyt1 Fam62a Mbc2
GRP1O95267Homo sapiens (Human)57.8110RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein)RASGRP1 RASGRP
SAVP22629Streptomyces avidinii56.7475110Streptavidin
protein targets having the best potency scores for SMB2 expression induction. Table contains additional info regarding the organism and the number of events in DB.

 

Download the extended SMN2 data sets