drTarget proposed protein targets for CoViD participating in pathways involved in SARS coronavirus disease by Reactome

All the interactions of these proteins linked to SARS pathways annotated in Reactome DB with actual or predicted SARS active compounds.

All proteins linked to SARS pathways annotated in Reactome DB interaction map. Protein colors by organism.

Note how SARS pathways from reactome contain proteins identified by drTarget algorithms as relevant for coronavirus infections.

geneName	protName	avgSARSScore	kindOfValue	organismType	Degree	protein_class_name
rep	Replicase polyprotein 1ab	5.23983187	actual	virus	147	Enzyme
1a	Replicase polyprotein 1a	5.146501741	actual	virus	101	Enzyme
VHL	von Hippel-Lindau disease tumor suppressor	4.412667156	actualAndPredicted	mammals	43	Unclassified protein
FURIN	Furin	3.804257957	predicted	mammals	169	Serine protease S8B subfamily
CRBN	Protein cereblon	4.397967462	actualAndPredicted	mammals	19	Unclassified protein
Sigmar1	Sigma non-opioid intracellular receptor 1	2.816706135	actualAndPredicted	mammals	692	Membrane receptor, Other membrane protein
NR3C1	Glucocorticoid receptor	2.841753598	actualAndPredicted	mammals	348	Nuclear hormone receptor subfamily 3 group C member 1
CYSLTR1	Cysteinyl leukotriene receptor 1	3.065313119	actualAndPredicted	mammals	182	Leukotriene receptor
BRD4	Bromodomain-containing protein 4	2.729343003	actualAndPredicted	mammals	218	Bromodomain
IL6R	Interleukin-6 receptor subunit alpha	4.640871157	actual	mammals	1	Membrane receptor, Secreted protein
JAK2	Tyrosine-protein kinase JAK2	2.364319566	actualAndPredicted	mammals	328	Tyrosine protein kinase JakA family, Tyrosine protein kinase JakB family
TUBB	Tubulin beta chain	2.879798395	actualAndPredicted	mammals	92	Structural protein
JAK1	Tyrosine-protein kinase JAK1	2.409715954	actualAndPredicted	mammals	195	Tyrosine protein kinase JakA family, Tyrosine protein kinase JakB family
JAK3	Tyrosine-protein kinase JAK3	2.312167295	actualAndPredicted	mammals	197	Tyrosine protein kinase JakA family, Tyrosine protein kinase JakB family
Hdac2	Histone deacetylase 2	2.364636615	actualAndPredicted	mammals	173	HDAC class I
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	2.811545153	actualAndPredicted	mammals	57	Isomerase
TBK1	Serine/threonine-protein kinase TBK1	2.492399882	actualAndPredicted	mammals	113	Other protein kinase IKK family
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	3.00165687	actualAndPredicted	mammals	25	Hydrolase, Sodium potassium ATPase

Predicted activities have been aggregated at the protein level into different scores attending to their potency, frequency of protein-molecule interactions, and specificity based on positive records vs total number of active records. Network graphs show all ChEMBL interactions of predicted active molecules. Barcharts and scatter plots show the aggregated potency against SARS-CoV (SARS_Score) vs the number of distinct molecular interactions for each protein (expressed as logged degree). Most interesting proteins attending to any of these values have been flagged in the scatter plots. Additional details as described in respective captions.

And how are these proteins linked to SARS pathways annotated in Reactome DB ranked by their combination of scores.

Log10(degree): logged number of interactions for each protein. SARS_Score: Aggregated score against coronavirus infection per protein. Size by Degree/CountOfScores represents the number of SARS active interactions vs total records per protein in ChEMBL.

Scatter plot flagging all ChEMBL proteins linked to SARS pathways annotated in Reactome DB. Note significant scores for SigmaR1, Jak & ROCK kinases, FURIN protease, viral replicases, FKBPs, histone deacetylase HDAC2, glucocorticoid receptor NR3C1, bromodomain protein BRD4, Ub-transference subunits like CRBN and VHL, leukotriene receptor CYSLTR1 and Interleukin-6 receptor.

Aggregated SARS scores at the protein level: Log10(degree): logged number of interactions for each protein. SARS_Score: Aggregated score against coronavirus infection per protein. Size by Degree/CountOfScores represents the number of SARS actiove interactions vs total records per protein in ChEMBL. Color by condition of elements involved in score aggregation; they can be built from actual, predicted values or a combination of both. Shape indicates the organism type as described in the legend.

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Click to download csv files with SARS predictions: 64k SARS active compounds, all interactions of active compounds and results aggregated at the target and pathway levels