| rep | Replicase polyprotein 1ab | 5.239832 | 147 | actual | Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) | virus | Enzyme |
| humanRhinovirusProtease | humanRhinovirusProtease | 3.507633 | 134 | actual&Predicted | Human rhinovirus sp. | virus | Cysteine protease C3A subfamily |
| CAPNS1 | Calpain small subunit 1 | 2.776558 | 5 | actual&Predicted | Homo sapiens (Human) - Sus scrofa (Pig) | mammals | Cysteine protease C2 regulatory subfamily |
| CTRA | Chymotrypsinogen A | 2.672555 | 16 | actual&Predicted | Bos taurus (Bovine) | mammals | Serine protease S1A subfamily |
| CAPN2 | Calpain-2 catalytic subunit | 2.556147 | 14 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Sus scrofa (Pig) | mammals | Cysteine protease C2 family |
| CAPN1 | Calpain-1 catalytic subunit | 2.527879 | 32 | actual&Predicted | Homo sapiens (Human) - Rattus norvegicus (Rat) - Sus scrofa (Pig) | mammals | Cysteine protease C2 family |
| Ctsb | Cathepsin B | 2.483321 | 47 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Cysteine protease C1A family |
| F2 | Prothrombin | 2.468271 | 192 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Serine protease S1A subfamily |
| TRY1 | Anionic trypsin-1 - Cationic trypsin - Trypsin-1 | 2.465278 | 100 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Rattus norvegicus (Rat) | mammals | Hydrolase, Serine protease S1A subfamily |
| Ctsl | Cathepsin L1 | 2.427165 | 49 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Cysteine protease C1A family |
| ELANE | Neutrophil elastase | 2.405196 | 82 | actual&Predicted | Homo sapiens (Human) - Mus musculus (Mouse) | mammals | Serine protease S1A subfamily |
| Ctsk | Cathepsin K | 2.375897 | 32 | actual&Predicted | Canis lupus familiaris (Dog) (Canis familiaris) - Homo sapiens (Human) - Mus musculus (Mouse) - Oryctolagus cuniculus (Rabbit) - Rattus norvegicus (Rat) | mammals | Cysteine protease C1A family |
| Ctss | Cathepsin S | 2.374385 | 38 | actual&Predicted | Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Cysteine protease C1A family |
| MMP2 | 72 kDa type IV collagenase | 2.260986 | 64 | actual&Predicted | Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Metallo protease M10A subfamily |
| MMP9 | Matrix metalloproteinase-9 | 2.258819 | 58 | actual&Predicted | Bos taurus (Bovine) - Homo sapiens (Human) - Mus musculus (Mouse) - Rattus norvegicus (Rat) | mammals | Metallo protease M10A subfamily |
| PAPA1 | Papain | 2.207048 | 4 | actual&Predicted | Carica papaya (Papaya) | plants | Cysteine protease C1A family |
| MMP17 | Matrix metalloproteinase-17 | 1.770478 | 1 | actual&Predicted | Homo sapiens (Human) | mammals | Metallo protease M10A subfamily |
