Selection of targets potentially involved in regulation of SMN2 expression.
In this section, we use only compounds predicted as active in 100% of occasions by random forest binomial models. From this data set, actual and predicted activities described in SMN2 prediction of activity section are aggregated by molecular target, obtaining a scoreForSMN2 from SMN2 predictions and actual values average, and scoreForTaget from the averaged experimental scores for each target.
Plot below shows molecular target with the highest likelihood of being involved in SMN2 expression.
Bar chart of the best scored molecular targets
Protein targets enhancers of SMN2 expression
protein targets having the best potency scores for SMB2 expression induction. Table contains additional info regarding the organism and the number of events in DB.