Selection of targets potentially involved in regulation of SMN2 expression.
In this section, we use only compounds predicted as active in 100% of occasions by random forest binomial models. From this data set, actual and predicted activities described in SMN2 prediction of activity section are aggregated by molecular target, obtaining a scoreForSMN2 from SMN2 predictions and actual values average, and scoreForTaget from the averaged experimental scores for each target.
Plot below shows molecular target with the highest likelihood of being involved in SMN2 expression.
Bar chart of the best scored molecular targets
Protein targets enhancers of SMN2 expression
| shortName | uniprot | Organism | scoreForTarget | scoreForSMN2 | countOfMolecules | TotalEvents | %ActualRecords | Protein names | Gene names |
|---|---|---|---|---|---|---|---|---|---|
| Q6Q793 | Q6Q793 | Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) | 9.28 | 7.05 | 1 | 1 | 0 | Neuraminidase (EC 3.2.1.18) | NA |
| ACPM | P52505 | Bos taurus (Bovine) | 8.941839134 | 5.574038462 | 13 | 26 | 0 | Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) | NDUFAB1 |
| NDUV1 | P25708 | Bos taurus (Bovine) | 8.941839134 | 5.574038462 | 13 | 26 | 0 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit) | NDUFV1 UQOR1 |
| MTOR | P42346 | Rattus norvegicus (Rat) | 8.786666667 | 5.745833333 | 3 | 3 | 0 | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) | Mtor Frap1 Raft1 |
| ADA1B | P18841 | Mesocricetus auratus (Golden hamster) | 8.7 | 6.225 | 1 | 1 | 0 | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | ADRA1B |
| DYR | P0A017 | Staphylococcus aureus | 8.58 | 6.1225 | 2 | 2 | 0 | Dihydrofolate reductase (DHFR) (EC 1.5.1.3) | folA |
| HEM6 | Q42840 | Hordeum vulgare (Barley) | 8.52 | 6.611439373 | 1 | 1 | 0 | Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) | CPX |
| MCHR1 | P97639 | Rattus norvegicus (Rat) | 8.395 | 5.7 | 1 | 2 | 0 | Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) | Mchr1 Gpr24 Slc1 |
| CSF1 | P07141 | Mus musculus (Mouse) | 8.332575749 | 5.577166667 | 5 | 6 | 0 | Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] | Csf1 Csfm |
| ADA17 | O77636 | Sus scrofa (Pig) | 7.97 | 5.821818182 | 11 | 11 | 0 | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) (Fragment) | ADAM17 TACE |
| CRFR2 | P47866 | Rattus norvegicus (Rat) | 7.939 | 6.30375 | 10 | 38 | 0 | Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) | Crhr2 Crf2r |
| SC5A5 | Q63008 | Rattus norvegicus (Rat) | 7.82 | 5.947916667 | 2 | 2 | 0 | Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) | Slc5a5 Nis |
| AT2A1 | P04191 | Oryctolagus cuniculus (Rabbit) | 7.7 | 6.16875 | 1 | 2 | 0 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) | ATP2A1 |
| Q46991 | Q46991 | Enterobacter cloacae | 7.55 | 5.8975 | 1 | 1 | 0 | Beta-lactamase (EC 3.5.2.6) | imiA blaIMI-1 imi-1 AW879_08570 |
| DYR | P16184 | Pneumocystis carinii | 7.29 | 5.883333333 | 3 | 3 | 0 | Dihydrofolate reductase (EC 1.5.1.3) | |
| ACM1 | P16395 | Drosophila melanogaster (Fruit fly) | 7.289899525 | 6.102291667 | 3 | 5 | 33.33333333 | Muscarinic acetylcholine receptor DM1 | mAChR-A AcrC mAcR-60C CG4356 |
| TM11D | O60235 | Homo sapiens (Human) | 7.2825 | 5.915625 | 4 | 4 | 0 | Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] | TMPRSS11D HAT |
| ADA1D | P97714 | Mus musculus (Mouse) | 7 | 6.0625 | 1 | 3 | 0 | Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) | Adra1d Adra1a Gpcr8 |
| ADA1A | P97718 | Mus musculus (Mouse) | 7 | 6.0625 | 1 | 3 | 0 | Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) | Adra1a Adra1c |
| ADA1B | P97717 | Mus musculus (Mouse) | 7 | 6.0625 | 1 | 3 | 0 | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) | Adra1b |
| SYI1 | P41972 | Staphylococcus aureus | 6.516666667 | 6.4425 | 3 | 3 | 0 | Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | ileS |
| CPT1A | P50416 | Homo sapiens (Human) | 6.5 | 6.1 | 1 | 1 | 0 | Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) | CPT1A CPT1 |
| NEP | P19621 | Sus scrofa (Pig) | 6.37 | 7.15 | 1 | 1 | 0 | Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) (Fragment) | MME |
| PDE4D | P14270 | Rattus norvegicus (Rat) | 6.28346716 | 6.065390625 | 8 | 47 | 0 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) | Pde4d |
| NRAM | P03470 | Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) | 6.12 | 6.363888889 | 3 | 4 | 0 | Neuraminidase (EC 3.2.1.18) | NA |
| ECR | P34021 | Drosophila melanogaster (Fruit fly) | 5.7425 | 6.1875 | 4 | 4 | 0 | Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) | EcR NR1H1 CG1765 |
| S22A7 | Q5RLM2 | Rattus norvegicus (Rat) | 5.74 | 7.3 | 1 | 1 | 100 | Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) | Slc22a7 Nlt Oat2 |
| ESYT1 | Q3U7R1 | Mus musculus (Mouse) | 5 | 7.3625 | 1 | 4 | 0 | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | Esyt1 Fam62a Mbc2 |
| GRP1 | O95267 | Homo sapiens (Human) | 5 | 7.8 | 1 | 1 | 0 | RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) | RASGRP1 RASGRP |
| SAV | P22629 | Streptomyces avidinii | 5 | 6.7475 | 1 | 1 | 0 | Streptavidin |