Best records from target to pathways annotation. Basically CountRatio>0.7 for targets and 0.6 for pathways.
BestTargetsAndPathways
| TargetName | pathway | organismC | proteinClassDescription | proteinIdentifiedFrom | AvgchemblActivityScoreC | BrCaActivities | TargetAvg(chemblActivityScoreC) | TargetCount(chemblActivityScoreC) | TargetcountRatio | numberOfProteinsWithRecords | pathwayproteinNames | pathwayAvgchemblActivityScoreC | pathwayCountchemblActivityScoreC | pathwaycountRatio | totalNumberOfProteinsInThePathway | rateProteinsWithRecordsVsTotalPathwayProteins | pathwayCountScore |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 26S proteosome | ABC-family proteins mediated transport | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.309661914 | 5488.44 | 1 | 1370 | 0.005109489 | 38419.08 |
| Proteasome Macropain subunit MB1 | ABC-family proteins mediated transport | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.309661914 | 5488.44 | 1 | 1370 | 0.005109489 | 38419.08 |
| Proteasome subunit beta type-7 | ABC-family proteins mediated transport | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.309661914 | 5488.44 | 1 | 1370 | 0.005109489 | 38419.08 |
| Histone deacetylase 3 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, epigenetic regulator writer hat src | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 4 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3, Nuclear receptor coactivator 3 | 5.640573077 | 2601.75 | 0.65061204 | 178 | 0.02247191 | 10407 |
| Histone deacetylase 1 | Activation of E2F1 target genes at G1/S | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme reductase, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 6 | CDK2/Cyclin A1, Dihydrofolate reductase, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Ribonucleoside-diphosphate reductase M2 chain | 5.94374298 | 1822.166667 | 0.700171356 | 37 | 0.162162162 | 10933 |
| Toll-like receptor 4/MD-2 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 44 | 0.045454545 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 44 | 0.045454545 | 106.8 |
| 26S proteosome | Activation of NF-kappaB in B cells | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 799 | 0.010012516 | 40659.85185 |
| Proteasome Macropain subunit MB1 | Activation of NF-kappaB in B cells | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 799 | 0.010012516 | 40659.85185 |
| Proteasome subunit beta type-7 | Activation of NF-kappaB in B cells | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 799 | 0.010012516 | 40659.85185 |
| Tubulin | Anchoring of the basal body to the plasma membrane | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 1243 | 0.003218021 | 153667.5 |
| Heat shock protein HSP90 | Anchoring of the basal body to the plasma membrane | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 1243 | 0.003218021 | 153667.5 |
| ORAI 1/2/3 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | Homo sapiens | enzyme, unclassified, ion channel other misc crac-c | chemblRecordsPrediction | 5.007619048 | Prediction | 5.007619048 | 567 | 0.761904762 | 2 | ORAI 1/2/3, PI3-kinase class I | 5.67987013 | 14011.5 | 0.709332334 | 433 | 0.004618938 | 28023 |
| 26S proteosome | Antigen processing: Ubiquitination & Proteasome degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2537 | 0.002364998 | 34302.25 |
| Proteasome Macropain subunit MB1 | Antigen processing: Ubiquitination & Proteasome degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2537 | 0.002364998 | 34302.25 |
| Proteasome subunit beta type-7 | Antigen processing: Ubiquitination & Proteasome degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2537 | 0.002364998 | 34302.25 |
| 26S proteosome | APC/C:Cdc20 mediated degradation of Securin | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 739 | 0.00811908 | 34302.25 |
| Proteasome Macropain subunit MB1 | APC/C:Cdc20 mediated degradation of Securin | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 739 | 0.00811908 | 34302.25 |
| Proteasome subunit beta type-7 | APC/C:Cdc20 mediated degradation of Securin | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 739 | 0.00811908 | 34302.25 |
| 26S proteosome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 960 | 0.00625 | 34302.25 |
| Proteasome Macropain subunit MB1 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 960 | 0.00625 | 34302.25 |
| Proteasome subunit beta type-7 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 960 | 0.00625 | 34302.25 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | Apoptotic cleavage of cellular proteins | Homo sapiens | auxiliary transport protein fabp, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 1 | Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 5 | 36 | 0.777777778 | 271 | 0.003690037 | 36 |
| Heat shock protein HSP90 | Aryl hydrocarbon receptor signalling | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 4.946290134 | 123 | 0.944838057 | 114 | 0.01754386 | 246 |
| Heat shock protein HSP 90-beta | Aryl hydrocarbon receptor signalling | Homo sapiens | cytosolic other | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 2 | Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 4.946290134 | 123 | 0.944838057 | 114 | 0.01754386 | 246 |
| Histone deacetylase 3 | Association of TriC/CCT with target proteins during biosynthesis | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 2 | Histone deacetylase, Histone deacetylase 3 | 5.383512152 | 5190 | 0.670542262 | 205 | 0.009756098 | 10380 |
| 26S proteosome | Asymmetric localization of PCP proteins | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 666 | 0.009009009 | 34302.25 |
| Proteasome Macropain subunit MB1 | Asymmetric localization of PCP proteins | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 666 | 0.009009009 | 34302.25 |
| Proteasome subunit beta type-7 | Asymmetric localization of PCP proteins | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 666 | 0.009009009 | 34302.25 |
| Heat shock protein HSP90 | Attenuation phase | Homo sapiens | cytosolic other, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 5 | CREB-binding protein, Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.188588412 | 96.66666667 | 0.769913968 | 289 | 0.017301038 | 483.3333333 |
| Heat shock protein HSP 90-beta | Attenuation phase | Homo sapiens | cytosolic other, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 5 | CREB-binding protein, Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.188588412 | 96.66666667 | 0.769913968 | 289 | 0.017301038 | 483.3333333 |
| 26S proteosome | AUF1 (hnRNP D0) binds and destabilizes mRNA | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 778 | 0.007712082 | 34302.25 |
| Proteasome Macropain subunit MB1 | AUF1 (hnRNP D0) binds and destabilizes mRNA | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 778 | 0.007712082 | 34302.25 |
| Proteasome subunit beta type-7 | AUF1 (hnRNP D0) binds and destabilizes mRNA | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 778 | 0.007712082 | 34302.25 |
| Tubulin | AURKA Activation by TPX2 | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 949 | 0.004214963 | 153667.5 |
| Heat shock protein HSP90 | AURKA Activation by TPX2 | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 949 | 0.004214963 | 153667.5 |
| 26S proteosome | Autodegradation of Cdh1 by Cdh1:APC/C | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 846 | 0.007092199 | 33482.45455 |
| Proteasome Macropain subunit MB1 | Autodegradation of Cdh1 by Cdh1:APC/C | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 846 | 0.007092199 | 33482.45455 |
| Proteasome subunit beta type-7 | Autodegradation of Cdh1 by Cdh1:APC/C | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 846 | 0.007092199 | 33482.45455 |
| 26S proteosome | Autodegradation of the E3 ubiquitin ligase COP1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 784 | 0.007653061 | 34302.25 |
| Proteasome Macropain subunit MB1 | Autodegradation of the E3 ubiquitin ligase COP1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 784 | 0.007653061 | 34302.25 |
| Proteasome subunit beta type-7 | Autodegradation of the E3 ubiquitin ligase COP1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 784 | 0.007653061 | 34302.25 |
| Sodium/potassium-transporting ATPase | Basigin interactions | Homo sapiens | enzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase, membrane receptor | chemblRecordsActualValues | 7.265 | Actual | 7.265 | 960 | 1 | 2 | Integrin alpha1/beta1 complex, Sodium/potassium-transporting ATPase | 7.31875 | 721 | 1 | 362 | 0.005524862 | 1442 |
| Somatostatin receptor | BBSome-mediated cargo-targeting to cilium | Homo sapiens | membrane receptor 7tm1 peptide short peptide somatostatin receptor | chemblRecordsActualValues | 8.66 | Actual | 8.66 | 25 | 1 | 1 | Somatostatin receptor | 8.66 | 25 | 1 | 147 | 0.006802721 | 25 |
| Histone deacetylase 3 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 3 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3 | 5.528591435 | 3465.333333 | 0.655361508 | 67 | 0.044776119 | 10396 |
| Tubulin | Carboxyterminal post-translational modifications of tubulin | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 129 | 0.031007752 | 202291.5294 |
| Tubulin beta-1 chain | Carboxyterminal post-translational modifications of tubulin | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 129 | 0.031007752 | 202291.5294 |
| 26S proteosome | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 1164 | 0.006013746 | 38425.24 |
| Proteasome Macropain subunit MB1 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 1164 | 0.006013746 | 38425.24 |
| Proteasome subunit beta type-7 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 1164 | 0.006013746 | 38425.24 |
| 26S proteosome | CDK-mediated phosphorylation and removal of Cdc6 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 929 | 0.007534984 | 38425.24 |
| Proteasome Macropain subunit MB1 | CDK-mediated phosphorylation and removal of Cdc6 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 929 | 0.007534984 | 38425.24 |
| Proteasome subunit beta type-7 | CDK-mediated phosphorylation and removal of Cdc6 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366522754 | 5489.32 | 0.98 | 929 | 0.007534984 | 38425.24 |
| 26S proteosome | CDT1 association with the CDC6:ORC:origin complex | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 679 | 0.008836524 | 34302.25 |
| Proteasome Macropain subunit MB1 | CDT1 association with the CDC6:ORC:origin complex | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 679 | 0.008836524 | 34302.25 |
| Proteasome subunit beta type-7 | CDT1 association with the CDC6:ORC:origin complex | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 679 | 0.008836524 | 34302.25 |
| Integrin alpha M | Cell surface interactions at the vascular wall | Homo sapiens | adhesion, adhesion, membrane receptor, membrane receptor | chemblRecordsPrediction | 5.044138505 | Prediction | 5.044138505 | 12 | 0.75 | 4 | Fibronectin, Integrin alpha M, Integrin alpha1/beta1 complex, Leukocyte adhesion glycoprotein LFA-1 alpha | 6.691659626 | 6 | 0.875 | 978 | 0.00408998 | 24 |
| Protein disulfide-isomerase | Chylomicron assembly | Homo sapiens | enzyme | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 1 | Protein disulfide-isomerase | 5.16416382 | 9 | 0.777777778 | 103 | 0.009708738 | 9 |
| Tubulin | Cilium Assembly | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 5 | Histone deacetylase, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.618174355 | 48339.05556 | 0.878736735 | 55 | 0.090909091 | 241695.2778 |
| Tubulin beta-1 chain | Cilium Assembly | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 5 | Histone deacetylase, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.618174355 | 48339.05556 | 0.878736735 | 55 | 0.090909091 | 241695.2778 |
| Histone deacetylase 3 | Circadian Clock | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 3 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3 | 5.470559721 | 4155.2 | 0.661433809 | 72 | 0.041666667 | 12465.6 |
| Cannabinoid CB1 receptor/orexin receptor 1 complex | Class A/1 (Rhodopsin-like receptors) | Homo sapiens | membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor lysophosphatidylinositol receptor | chemblRecordsPrediction | 5.933538486 | Prediction | 5.933538486 | 72 | 0.722222222 | 2 | Cannabinoid CB1 receptor/orexin receptor 1 complex, G-protein coupled receptor 55 | 5.85843591 | 37.5 | 0.694444444 | 199 | 0.010050251 | 75 |
| 26S proteosome | CLEC7A (Dectin-1) signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.286544044 | 5277.846154 | 0.971153846 | 838 | 0.009546539 | 42222.76923 |
| Proteasome Macropain subunit MB1 | CLEC7A (Dectin-1) signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.286544044 | 5277.846154 | 0.971153846 | 838 | 0.009546539 | 42222.76923 |
| Proteasome subunit beta type-7 | CLEC7A (Dectin-1) signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.286544044 | 5277.846154 | 0.971153846 | 838 | 0.009546539 | 42222.76923 |
| Protein disulfide-isomerase | Collagen biosynthesis and modifying enzymes | Homo sapiens | enzyme | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 1 | Protein disulfide-isomerase | 5.16416382 | 9 | 0.777777778 | 807 | 0.001239157 | 9 |
| Casein kinase II alpha/beta | Condensation of Prometaphase Chromosomes | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 1 | Casein kinase II alpha/beta | 8 | 16 | 0.75 | 157 | 0.006369427 | 16 |
| Heat shock protein HSP90 | Constitutive Signaling by EGFRvIII | Homo sapiens | cytosolic other, enzyme, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 3 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, PI3-kinase class I | 5.767347487 | 13800 | 0.704581876 | 15 | 0.2 | 41400 |
| Heat shock protein HSP90 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Homo sapiens | cytosolic other, enzyme, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 3 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, PI3-kinase class I | 5.767347487 | 13800 | 0.704581876 | 19 | 0.157894737 | 41400 |
| Histone deacetylase 3 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 4 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.026986893 | 18 | 0.888888889 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 | |
| Histone deacetylase 1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 7 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.212371251 | 8 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 | |
| Histone deacetylase 2 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 8 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 4.926546368 | Actual | 4.926546368 | 13 | 0.769230769 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 3 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 4 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.026986893 | 18 | 0.888888889 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 | |
| Histone deacetylase 1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 7 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.212371251 | 8 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 | |
| Histone deacetylase 2 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Histone deacetylase 8 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 4.926546368 | Actual | 4.926546368 | 13 | 0.769230769 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.209703724 | 5706.6 | 0.692906331 | 58 | 0.155172414 | 51359.4 |
| Casein kinase II alpha/beta | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 1 | Casein kinase II alpha/beta | 8 | 16 | 0.75 | 424 | 0.002358491 | 16 |
| Tubulin | COPI-dependent Golgi-to-ER retrograde traffic | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 910 | 0.004395604 | 202291.5294 |
| Tubulin beta-1 chain | COPI-dependent Golgi-to-ER retrograde traffic | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 910 | 0.004395604 | 202291.5294 |
| Tubulin | COPI-independent Golgi-to-ER retrograde traffic | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 517 | 0.007736944 | 202291.5294 |
| Tubulin beta-1 chain | COPI-independent Golgi-to-ER retrograde traffic | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 517 | 0.007736944 | 202291.5294 |
| Tubulin | COPI-mediated anterograde transport | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 1275 | 0.003137255 | 202291.5294 |
| Tubulin beta-1 chain | COPI-mediated anterograde transport | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 1275 | 0.003137255 | 202291.5294 |
| 26S proteosome | Cross-presentation of soluble exogenous antigens (endosomes) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 894 | 0.006711409 | 34302.25 |
| Proteasome Macropain subunit MB1 | Cross-presentation of soluble exogenous antigens (endosomes) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 894 | 0.006711409 | 34302.25 |
| Proteasome subunit beta type-7 | Cross-presentation of soluble exogenous antigens (endosomes) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 894 | 0.006711409 | 34302.25 |
| Histone deacetylase 1 | Deactivation of the beta-catenin transactivating complex | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 3 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.622985308 | 3471.666667 | 0.814049451 | 452 | 0.006637168 | 10415 |
| 26S proteosome | Dectin-1 mediated noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.329472473 | 5488.84 | 0.983333333 | 703 | 0.009957326 | 38421.88 |
| Proteasome Macropain subunit MB1 | Dectin-1 mediated noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.329472473 | 5488.84 | 0.983333333 | 703 | 0.009957326 | 38421.88 |
| Proteasome subunit beta type-7 | Dectin-1 mediated noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.329472473 | 5488.84 | 0.983333333 | 703 | 0.009957326 | 38421.88 |
| 26S proteosome | Defective CFTR causes cystic fibrosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 61 | 0.098360656 | 34302.25 |
| Proteasome Macropain subunit MB1 | Defective CFTR causes cystic fibrosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 61 | 0.098360656 | 34302.25 |
| Proteasome subunit beta type-7 | Defective CFTR causes cystic fibrosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 61 | 0.098360656 | 34302.25 |
| 26S proteosome | Degradation of AXIN | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 674 | 0.008902077 | 34302.25 |
| Proteasome Macropain subunit MB1 | Degradation of AXIN | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 674 | 0.008902077 | 34302.25 |
| Proteasome subunit beta type-7 | Degradation of AXIN | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 674 | 0.008902077 | 34302.25 |
| 26S proteosome | Degradation of beta-catenin by the destruction complex | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform | 6.512052983 | 5488.48 | 1 | 755 | 0.009271523 | 38419.36 |
| Proteasome Macropain subunit MB1 | Degradation of beta-catenin by the destruction complex | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform | 6.512052983 | 5488.48 | 1 | 755 | 0.009271523 | 38419.36 |
| Proteasome subunit beta type-7 | Degradation of beta-catenin by the destruction complex | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform | 6.512052983 | 5488.48 | 1 | 755 | 0.009271523 | 38419.36 |
| 26S proteosome | Degradation of DVL | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 907 | 0.006615215 | 34302.25 |
| Proteasome Macropain subunit MB1 | Degradation of DVL | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 907 | 0.006615215 | 34302.25 |
| Proteasome subunit beta type-7 | Degradation of DVL | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 907 | 0.006615215 | 34302.25 |
| 26S proteosome | Degradation of GLI1 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 676 | 0.00887574 | 34302.25 |
| Proteasome Macropain subunit MB1 | Degradation of GLI1 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 676 | 0.00887574 | 34302.25 |
| Proteasome subunit beta type-7 | Degradation of GLI1 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 676 | 0.00887574 | 34302.25 |
| 26S proteosome | Degradation of GLI2 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 64 | 0.09375 | 34302.25 |
| Proteasome Macropain subunit MB1 | Degradation of GLI2 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 64 | 0.09375 | 34302.25 |
| Proteasome subunit beta type-7 | Degradation of GLI2 by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 64 | 0.09375 | 34302.25 |
| Protein disulfide-isomerase | Detoxification of Reactive Oxygen Species | Homo sapiens | enzyme | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 2 | Protein disulfide-isomerase, Thioredoxin reductase 2 | 5.08208191 | 5.5 | 0.888888889 | 571 | 0.003502627 | 11 |
| Heat shock protein HSP90 | Downregulation of ERBB2 signaling | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 327 | 0.006116208 | 288 |
| Histone deacetylase 1 | Downregulation of SMAD2/3:SMAD4 transcriptional activity | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 3 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.622985308 | 3471.666667 | 0.814049451 | 374 | 0.00802139 | 10415 |
| 26S proteosome | Downstream TCR signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, enzyme, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 9 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, PI3-kinase class I, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.295287667 | 8234.933333 | 0.929234654 | 965 | 0.009326425 | 74114.4 |
| Proteasome Macropain subunit MB1 | Downstream TCR signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, enzyme, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 9 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, PI3-kinase class I, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.295287667 | 8234.933333 | 0.929234654 | 965 | 0.009326425 | 74114.4 |
| Proteasome subunit beta type-7 | Downstream TCR signaling | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, enzyme, unclassified, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 9 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, PI3-kinase class I, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.295287667 | 8234.933333 | 0.929234654 | 965 | 0.009326425 | 74114.4 |
| ORAI 1/2/3 | Elevation of cytosolic Ca2+ levels | Homo sapiens | ion channel other misc crac-c | chemblRecordsPrediction | 5.007619048 | Prediction | 5.007619048 | 567 | 0.761904762 | 1 | ORAI 1/2/3 | 5.007619048 | 567 | 0.761904762 | 201 | 0.004975124 | 567 |
| Heat shock protein HSP90 | eNOS activation | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 118 | 0.016949153 | 288 |
| Heat shock protein HSP90 | EPHA-mediated growth cone collapse | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 382 | 0.005235602 | 288 |
| Histone deacetylase 1 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 78 | 0.051282051 | 13868 |
| Histone deacetylase 2 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 78 | 0.051282051 | 13868 |
| 26S proteosome | ER-Phagosome pathway | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, surface antigen, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 6.130620388 | 4740.551724 | 1 | 257 | 0.031128405 | 37924.41379 |
| Toll-like receptor 4/MD-2 | ER-Phagosome pathway | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, surface antigen, unclassified | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 8 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 6.130620388 | 4740.551724 | 1 | 257 | 0.031128405 | 37924.41379 |
| Toll-like receptor 4/MD-2/CD14 | ER-Phagosome pathway | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, surface antigen, unclassified | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 8 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 6.130620388 | 4740.551724 | 1 | 257 | 0.031128405 | 37924.41379 |
| Proteasome Macropain subunit MB1 | ER-Phagosome pathway | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, surface antigen, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 6.130620388 | 4740.551724 | 1 | 257 | 0.031128405 | 37924.41379 |
| Proteasome subunit beta type-7 | ER-Phagosome pathway | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, surface antigen, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 6.130620388 | 4740.551724 | 1 | 257 | 0.031128405 | 37924.41379 |
| Histone deacetylase 1 | Factors involved in megakaryocyte development and platelet production | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 6 | CDK2/Cyclin A1, CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.704226981 | 2605.25 | 0.74346332 | 965 | 0.006217617 | 15631.5 |
| Histone deacetylase 2 | Factors involved in megakaryocyte development and platelet production | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 6 | CDK2/Cyclin A1, CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.704226981 | 2605.25 | 0.74346332 | 965 | 0.006217617 | 15631.5 |
| 26S proteosome | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 801 | 0.007490637 | 34302.25 |
| Proteasome Macropain subunit MB1 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 801 | 0.007490637 | 34302.25 |
| Proteasome subunit beta type-7 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 801 | 0.007490637 | 34302.25 |
| 26S proteosome | FCERI mediated NF-kB activation | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 1035 | 0.007729469 | 40659.85185 |
| Proteasome Macropain subunit MB1 | FCERI mediated NF-kB activation | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 1035 | 0.007729469 | 40659.85185 |
| Proteasome subunit beta type-7 | FCERI mediated NF-kB activation | Homo sapiens | enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.246795499 | 5082.481481 | 0.959876543 | 1035 | 0.007729469 | 40659.85185 |
| Histone deacetylase 1 | Formation of the beta-catenin:TCF transactivating complex | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.671926481 | 2607.75 | 0.766787088 | 413 | 0.00968523 | 10431 |
| Tubulin | Formation of tubulin folding intermediates by CCT/TriC | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.665303734 | 49895.625 | 0.896417143 | 25 | 0.16 | 199582.5 |
| Tubulin beta-1 chain | Formation of tubulin folding intermediates by CCT/TriC | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.665303734 | 49895.625 | 0.896417143 | 25 | 0.16 | 199582.5 |
| Cannabinoid CB1 receptor/orexin receptor 1 complex | G alpha (i) signalling events | Homo sapiens | ion channel other toxin, membrane receptor 7tm1 peptide short peptide galanin receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor, membrane receptor 7tm1 peptide short peptide somatostatin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor edg receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor lysophosphatidylinositol receptor, unclassified | chemblRecordsPrediction | 5.933538486 | Prediction | 5.933538486 | 72 | 0.722222222 | 8 | Cannabinoid CB1 receptor/orexin receptor 1 complex, G-protein coupled receptor 55, Galanin receptor 2, Kininogen-1, Opioid receptors; delta & kappa, Proenkephalin B, Somatostatin receptor, Sphingosine 1-phosphate receptor Edg-5 | 7.524287859 | 52.53846154 | 0.811947014 | 1881 | 0.004253057 | 420.3076923 |
| Somatostatin receptor | G alpha (i) signalling events | Homo sapiens | ion channel other toxin, membrane receptor 7tm1 peptide short peptide galanin receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor, membrane receptor 7tm1 peptide short peptide somatostatin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor edg receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor lysophosphatidylinositol receptor, unclassified | chemblRecordsActualValues | 8.66 | Actual | 8.66 | 25 | 1 | 8 | Cannabinoid CB1 receptor/orexin receptor 1 complex, G-protein coupled receptor 55, Galanin receptor 2, Kininogen-1, Opioid receptors; delta & kappa, Proenkephalin B, Somatostatin receptor, Sphingosine 1-phosphate receptor Edg-5 | 7.524287859 | 52.53846154 | 0.811947014 | 1881 | 0.004253057 | 420.3076923 |
| Cannabinoid CB1 receptor/orexin receptor 1 complex | G alpha (q) signalling events | Homo sapiens | enzyme, unclassified, membrane receptor 7tm1 peptide protease-activated receptor, membrane receptor 7tm1 peptide protease-activated receptor protease-activated receptor, membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor, membrane receptor 7tm1 smallmol monoamine receptor acetylcholine receptor, unclassified | chemblRecordsPrediction | 5.933538486 | Prediction | 5.933538486 | 72 | 0.722222222 | 7 | Cannabinoid CB1 receptor/orexin receptor 1 complex, Kininogen-1, Muscarinic acetylcholine receptor M1/M5 chimeric protein, Orexin receptor 1, Orexin receptor 2, PI3-kinase class I, Proteinase-activated receptor 2 | 6.297454988 | 10021.45455 | 0.724566326 | 1606 | 0.004358655 | 70150.18182 |
| Histone deacetylase 1 | G0 and Early G1 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | CDK2/Cyclin A1, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.923822221 | 2092.6 | 0.688429671 | 306 | 0.013071895 | 8370.4 |
| 26S proteosome | G2/M Checkpoints | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 477 | 0.012578616 | 34302.25 |
| Proteasome Macropain subunit MB1 | G2/M Checkpoints | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 477 | 0.012578616 | 34302.25 |
| Proteasome subunit beta type-7 | G2/M Checkpoints | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 477 | 0.012578616 | 34302.25 |
| Tubulin | Gap junction assembly | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 69 | 0.057971014 | 202291.5294 |
| Tubulin beta-1 chain | Gap junction assembly | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 69 | 0.057971014 | 202291.5294 |
| 26S proteosome | GLI3 is processed to GLI3R by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 681 | 0.008810573 | 34302.25 |
| Proteasome Macropain subunit MB1 | GLI3 is processed to GLI3R by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 681 | 0.008810573 | 34302.25 |
| Proteasome subunit beta type-7 | GLI3 is processed to GLI3R by the proteasome | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 681 | 0.008810573 | 34302.25 |
| Histone deacetylase 3 | HDACs deacetylate histones | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iib | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 8 | 5.317523925 | 4327.083333 | 0.759599242 | 314 | 0.022292994 | 30289.58333 |
| Histone deacetylase 1 | HDACs deacetylate histones | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iib | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 8 | 5.317523925 | 4327.083333 | 0.759599242 | 314 | 0.022292994 | 30289.58333 |
| Histone deacetylase 2 | HDACs deacetylate histones | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iib | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 8 | 5.317523925 | 4327.083333 | 0.759599242 | 314 | 0.022292994 | 30289.58333 |
| Histone deacetylase 8 | HDACs deacetylate histones | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iib | chemblRecordsActualValues | 4.926546368 | Actual | 4.926546368 | 13 | 0.769230769 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 8 | 5.317523925 | 4327.083333 | 0.759599242 | 314 | 0.022292994 | 30289.58333 |
| 26S proteosome | Hedgehog ligand biogenesis | Homo sapiens | enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Protein disulfide-isomerase | 6.318086203 | 5488.72 | 0.991111111 | 753 | 0.009296149 | 38421.04 |
| Protein disulfide-isomerase | Hedgehog ligand biogenesis | Homo sapiens | enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Protein disulfide-isomerase | 6.318086203 | 5488.72 | 0.991111111 | 753 | 0.009296149 | 38421.04 |
| Proteasome Macropain subunit MB1 | Hedgehog ligand biogenesis | Homo sapiens | enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Protein disulfide-isomerase | 6.318086203 | 5488.72 | 0.991111111 | 753 | 0.009296149 | 38421.04 |
| Proteasome subunit beta type-7 | Hedgehog ligand biogenesis | Homo sapiens | enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Protein disulfide-isomerase | 6.318086203 | 5488.72 | 0.991111111 | 753 | 0.009296149 | 38421.04 |
| Tubulin | Hedgehog 'off' state | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.67922968 | 49128.06667 | 0.897278125 | 618 | 0.006472492 | 196512.2667 |
| Tubulin beta-1 chain | Hedgehog 'off' state | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.67922968 | 49128.06667 | 0.897278125 | 618 | 0.006472492 | 196512.2667 |
| 26S proteosome | Hedgehog 'on' state | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1247 | 0.004811548 | 34302.25 |
| Proteasome Macropain subunit MB1 | Hedgehog 'on' state | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1247 | 0.004811548 | 34302.25 |
| Proteasome subunit beta type-7 | Hedgehog 'on' state | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1247 | 0.004811548 | 34302.25 |
| Uroporphyrinogen-III synthase | Heme biosynthesis | Homo sapiens | enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 11 | 0.909090909 | 1 | Uroporphyrinogen-III synthase | 5 | 11 | 0.909090909 | 214 | 0.004672897 | 11 |
| 26S proteosome | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Proteasome Macropain subunit MB1 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Proteasome subunit beta type-7 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Heat shock protein HSP90 | HSF1 activation | Homo sapiens | cytosolic other, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 5 | Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Histone deacetylase | 5.05644076 | 1821.333333 | 0.764261388 | 258 | 0.019379845 | 9106.666667 |
| Heat shock protein HSP 90-beta | HSF1 activation | Homo sapiens | cytosolic other, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 5 | Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Histone deacetylase | 5.05644076 | 1821.333333 | 0.764261388 | 258 | 0.019379845 | 9106.666667 |
| Heat shock protein HSP90 | HSF1-dependent transactivation | Homo sapiens | cytosolic other, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.062556094 | 112.8 | 0.798896761 | 495 | 0.008080808 | 451.2 |
| Heat shock protein HSP 90-beta | HSF1-dependent transactivation | Homo sapiens | cytosolic other, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 4 | Heat shock factor protein 1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.062556094 | 112.8 | 0.798896761 | 495 | 0.008080808 | 451.2 |
| Tubulin | HSP90 chaperone cycle for steroid hormone receptors (SHR) | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 7 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.540904861 | 40965.38095 | 0.88669812 | 562 | 0.012455516 | 286757.6667 |
| Heat shock protein HSP90 | HSP90 chaperone cycle for steroid hormone receptors (SHR) | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 7 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.540904861 | 40965.38095 | 0.88669812 | 562 | 0.012455516 | 286757.6667 |
| Heat shock protein HSP 90-beta | HSP90 chaperone cycle for steroid hormone receptors (SHR) | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 7 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.540904861 | 40965.38095 | 0.88669812 | 562 | 0.012455516 | 286757.6667 |
| Tubulin beta-1 chain | HSP90 chaperone cycle for steroid hormone receptors (SHR) | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 7 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.540904861 | 40965.38095 | 0.88669812 | 562 | 0.012455516 | 286757.6667 |
| Toll-like receptor 4/MD-2 | IKK complex recruitment mediated by RIP1 | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 4 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.317215974 | 75.71428571 | 0.904062653 | 24 | 0.166666667 | 302.8571429 |
| Toll-like receptor 4/MD-2/CD14 | IKK complex recruitment mediated by RIP1 | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 4 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.317215974 | 75.71428571 | 0.904062653 | 24 | 0.166666667 | 302.8571429 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | IKK complex recruitment mediated by RIP1 | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 4 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.317215974 | 75.71428571 | 0.904062653 | 24 | 0.166666667 | 302.8571429 |
| Protein farnesyltransferase beta subunit | Inactivation, recovery and regulation of the phototransduction cascade | Homo sapiens | enzyme | chemblRecordsPrediction | 4.74155932 | Prediction | 4.74155932 | 24 | 0.791666667 | 1 | Protein farnesyltransferase beta subunit | 4.74155932 | 24 | 0.791666667 | 457 | 0.002188184 | 24 |
| Integrin alpha M | Integrin cell surface interactions | Homo sapiens | adhesion, adhesion, membrane receptor, membrane receptor, unclassified | chemblRecordsPrediction | 5.044138505 | Prediction | 5.044138505 | 12 | 0.75 | 7 | Fibronectin, Integrin alpha M, Integrin alpha-V/beta-3, Integrin alpha1/beta1 complex, Leukocyte adhesion glycoprotein LFA-1 alpha, Vitronectin, von Willebrand factor | 7.006494979 | 5.769230769 | 0.933566434 | 1089 | 0.006427916 | 40.38461538 |
| 26S proteosome | Interferon alpha/beta signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 2 | 26S proteosome, Proteasome subunit beta type-8 | 6.412302652 | 3612 | 1 | 291 | 0.006872852 | 7224 |
| 26S proteosome | Interleukin-1 family signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, secreted, transcription factor, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Interleukin-1 beta, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.282459795 | 5278 | 0.972985348 | 1108 | 0.007220217 | 42224 |
| Proteasome Macropain subunit MB1 | Interleukin-1 family signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, secreted, transcription factor, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Interleukin-1 beta, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.282459795 | 5278 | 0.972985348 | 1108 | 0.007220217 | 42224 |
| Proteasome subunit beta type-7 | Interleukin-1 family signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, secreted, transcription factor, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Interleukin-1 beta, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.282459795 | 5278 | 0.972985348 | 1108 | 0.007220217 | 42224 |
| Interleukin-1 beta | Interleukin-1 processing | Homo sapiens | secreted, transcription factor | chemblRecordsPrediction | 5.107142857 | Prediction | 5.107142857 | 7 | 0.714285714 | 2 | Interleukin-1 beta, Nuclear factor NF-kappa-B p65 subunit | 5.27798171 | 9.5 | 0.648809524 | 69 | 0.028985507 | 19 |
| Protein disulfide-isomerase | Interleukin-12 family signaling | Homo sapiens | enzyme | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 1 | Protein disulfide-isomerase | 5.16416382 | 9 | 0.777777778 | 230 | 0.004347826 | 9 |
| Interleukin-1 beta | Interleukin-4 and 13 signaling | Homo sapiens | adhesion, cytosolic other, enzyme, enzyme, unclassified, membrane receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, secreted | chemblRecordsPrediction | 5.107142857 | Prediction | 5.107142857 | 7 | 0.714285714 | 9 | Fibronectin, Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Heme oxygenase 1, Integrin alpha M, Integrin alpha1/beta1 complex, Interleukin-1 beta, Opioid receptors; delta & kappa, PI3-kinase class I | 6.163846248 | 3105.555556 | 0.766508954 | 258 | 0.034883721 | 27950 |
| Heat shock protein HSP90 | Interleukin-4 and 13 signaling | Homo sapiens | adhesion, cytosolic other, enzyme, enzyme, unclassified, membrane receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, secreted | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 9 | Fibronectin, Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Heme oxygenase 1, Integrin alpha M, Integrin alpha1/beta1 complex, Interleukin-1 beta, Opioid receptors; delta & kappa, PI3-kinase class I | 6.163846248 | 3105.555556 | 0.766508954 | 258 | 0.034883721 | 27950 |
| Integrin alpha M | Interleukin-4 and 13 signaling | Homo sapiens | adhesion, cytosolic other, enzyme, enzyme, unclassified, membrane receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, secreted | chemblRecordsPrediction | 5.044138505 | Prediction | 5.044138505 | 12 | 0.75 | 9 | Fibronectin, Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Heme oxygenase 1, Integrin alpha M, Integrin alpha1/beta1 complex, Interleukin-1 beta, Opioid receptors; delta & kappa, PI3-kinase class I | 6.163846248 | 3105.555556 | 0.766508954 | 258 | 0.034883721 | 27950 |
| Tubulin | Intraflagellar transport | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.67922968 | 49128.06667 | 0.897278125 | 627 | 0.006379585 | 196512.2667 |
| Tubulin beta-1 chain | Intraflagellar transport | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.67922968 | 49128.06667 | 0.897278125 | 627 | 0.006379585 | 196512.2667 |
| Sodium/potassium-transporting ATPase | Ion homeostasis | Homo sapiens | enzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase, enzyme hydrolase, transporter ntpase p-type atpase na k atpase, ion channel other misc crac-c | chemblRecordsActualValues | 7.265 | Actual | 7.265 | 960 | 1 | 3 | ORAI 1/2/3, Sodium/potassium-transporting ATPase, Sodium/potassium-transporting ATPase alpha-1 chain | 6.821385281 | 801.8181818 | 0.956709957 | 847 | 0.003541913 | 2405.454545 |
| ORAI 1/2/3 | Ion homeostasis | Homo sapiens | enzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase, enzyme hydrolase, transporter ntpase p-type atpase na k atpase, ion channel other misc crac-c | chemblRecordsPrediction | 5.007619048 | Prediction | 5.007619048 | 567 | 0.761904762 | 3 | ORAI 1/2/3, Sodium/potassium-transporting ATPase, Sodium/potassium-transporting ATPase alpha-1 chain | 6.821385281 | 801.8181818 | 0.956709957 | 847 | 0.003541913 | 2405.454545 |
| Sodium/potassium-transporting ATPase | Ion transport by P-type ATPases | Homo sapiens | enzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase, enzyme hydrolase, transporter ntpase p-type atpase h k atpase, enzyme hydrolase, transporter ntpase p-type atpase na k atpase | chemblRecordsActualValues | 7.265 | Actual | 7.265 | 960 | 1 | 3 | Potassium-transporting ATPase alpha chain 2, Sodium/potassium-transporting ATPase, Sodium/potassium-transporting ATPase alpha-1 chain | 7.212 | 768.8 | 1 | 864 | 0.003472222 | 2306.4 |
| Toll-like receptor 4/MD-2 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 123 | 0.016260163 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 123 | 0.016260163 | 106.8 |
| Toll-like receptor 4/MD-2 | IRAK4 deficiency (TLR2/4) | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 12 | 0.166666667 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | IRAK4 deficiency (TLR2/4) | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 12 | 0.166666667 | 106.8 |
| Tubulin | Kinesins | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 373 | 0.010723861 | 202291.5294 |
| Tubulin beta-1 chain | Kinesins | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 373 | 0.010723861 | 202291.5294 |
| Toll-like receptor 4/MD-2 | Ligand-dependent caspase activation | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 18 | 0.111111111 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | Ligand-dependent caspase activation | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 18 | 0.111111111 | 106.8 |
| Tubulin | Loss of Nlp from mitotic centrosomes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 906 | 0.004415011 | 153667.5 |
| Heat shock protein HSP90 | Loss of Nlp from mitotic centrosomes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 906 | 0.004415011 | 153667.5 |
| Tubulin | Loss of proteins required for interphase microtubule organization from the centrosome | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 69 | 0.057971014 | 153667.5 |
| Heat shock protein HSP90 | Loss of proteins required for interphase microtubule organization from the centrosome | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 69 | 0.057971014 | 153667.5 |
| 26S proteosome | MAPK6/MAPK4 signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, epigenetic regulator writer hat src, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Nuclear receptor coactivator 3, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.35058037 | 5488.8 | 0.985454545 | 989 | 0.007077856 | 38421.6 |
| Proteasome Macropain subunit MB1 | MAPK6/MAPK4 signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, epigenetic regulator writer hat src, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Nuclear receptor coactivator 3, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.35058037 | 5488.8 | 0.985454545 | 989 | 0.007077856 | 38421.6 |
| Proteasome subunit beta type-7 | MAPK6/MAPK4 signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, epigenetic regulator writer hat src, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Nuclear receptor coactivator 3, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.35058037 | 5488.8 | 0.985454545 | 989 | 0.007077856 | 38421.6 |
| Tubulin | MHC class II antigen presentation | Homo sapiens | enzyme protease serine sc s10, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 5 | Lysosomal protective protein, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.618959683 | 47763.33333 | 0.901454262 | 1114 | 0.00448833 | 238816.6667 |
| Tubulin beta-1 chain | MHC class II antigen presentation | Homo sapiens | enzyme protease serine sc s10, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 5 | Lysosomal protective protein, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.618959683 | 47763.33333 | 0.901454262 | 1114 | 0.00448833 | 238816.6667 |
| Tubulin | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 28 | 0.142857143 | 202291.5294 |
| Tubulin beta-1 chain | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 28 | 0.142857143 | 202291.5294 |
| Tubulin | Mitotic Prometaphase | Homo sapiens | enzyme phosphatase protein phosphatase reg, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 5 | Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.895255979 | 47763.44444 | 0.901454262 | 953 | 0.00524659 | 238817.2222 |
| Tubulin beta-1 chain | Mitotic Prometaphase | Homo sapiens | enzyme phosphatase protein phosphatase reg, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 5 | Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.895255979 | 47763.44444 | 0.901454262 | 953 | 0.00524659 | 238817.2222 |
| Splicing factor 3B subunit 3 | mRNA Splicing - Major Pathway | Homo sapiens | unclassified | chemblRecordsPrediction | 6.081626853 | Prediction | 6.081626853 | 53 | 0.698113208 | 3 | Heterogeneous nuclear ribonucleoprotein A1, Polypyrimidine tract-binding protein 1, Splicing factor 3B subunit 3 | 5.433875618 | 19.66666667 | 0.899371069 | 3115 | 0.000963082 | 59 |
| Toll-like receptor 4/MD-2 | MyD88 deficiency (TLR2/4) | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 12 | 0.166666667 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | MyD88 deficiency (TLR2/4) | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 12 | 0.166666667 | 106.8 |
| Toll-like receptor 4/MD-2 | MyD88:Mal cascade initiated on plasma membrane | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 49 | 0.040816327 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | MyD88:Mal cascade initiated on plasma membrane | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 49 | 0.040816327 | 106.8 |
| Toll-like receptor 4/MD-2 | MyD88-independent TLR3/TLR4 cascade | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 41 | 0.048780488 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | MyD88-independent TLR3/TLR4 cascade | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 41 | 0.048780488 | 106.8 |
| 26S proteosome | Neddylation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2529 | 0.002372479 | 34302.25 |
| Proteasome Macropain subunit MB1 | Neddylation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2529 | 0.002372479 | 34302.25 |
| Proteasome subunit beta type-7 | Neddylation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 2529 | 0.002372479 | 34302.25 |
| Arginase-1 | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsPrediction | 6.126875 | Prediction | 6.126875 | 64 | 0.84375 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Tubulin | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Heat shock protein HSP90 | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Heat shock protein HSP 90-beta | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Toll-like receptor 4/MD-2/CD14 | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Integrin alpha M | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsPrediction | 5.044138505 | Prediction | 5.044138505 | 12 | 0.75 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| 26S proteosome | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Casein kinase II alpha/beta | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| Proteasome subunit beta type-7 | Neutrophil degranulation | Homo sapiens | adhesion, membrane receptor, cytosolic other, enzyme, enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease cysteine ca c1a, enzyme protease cysteine ca c2, enzyme protease cysteine ca c2 reg, enzyme protease serine sc s10, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, membrane receptor, membrane receptor, surface antigen, structural, transporter electrochemical slc slc21, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 24 | 26S proteosome, Arginase-1, Calpain 1, Casein kinase II alpha/beta, Cathepsin Z, Cytidine deaminase, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Integrin alpha M, Integrin alpha-V/beta-3, Leukocyte adhesion glycoprotein LFA-1 alpha, Low affinity immunoglobulin gamma Fc region receptor II-a, Lysosomal protective protein, MAP kinase p38, Mitogen-activated protein kinase; ERK1/ERK2, Proteasome component C5, Proteasome subunit beta type-7, Protein-arginine deiminase type-2, Ras-related protein Rap-1A, Solute carrier organic anion transporter family member 4C1, Toll-like receptor 4/MD-2/CD14, Tubulin, Tubulin beta-2 chain | 5.717195848 | 5259.896552 | 0.903628919 | 8936 | 0.002685765 | 126237.5172 |
| 26S proteosome | NIK-->noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 702 | 0.008547009 | 34302.25 |
| Proteasome Macropain subunit MB1 | NIK-->noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 702 | 0.008547009 | 34302.25 |
| Proteasome subunit beta type-7 | NIK-->noncanonical NF-kB signaling | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 702 | 0.008547009 | 34302.25 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | NOD1/2 Signaling Pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, enzyme kinase protein kinase cmgc mapk p38 | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 3 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, MAP kinase p38 | 5.08381255 | 150.5 | 0.621406428 | 332 | 0.009036145 | 451.5 |
| Histone deacetylase 1 | NoRC negatively regulates rRNA expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 176 | 0.022727273 | 13868 |
| Histone deacetylase 2 | NoRC negatively regulates rRNA expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 176 | 0.022727273 | 13868 |
| Histone deacetylase 3 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 |
| Histone deacetylase 4 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.026986893 | 18 | 0.888888889 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 | |
| Histone deacetylase 1 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 |
| Histone deacetylase 7 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | Actual | 4.212371251 | 8 | 0.75 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 | |
| Histone deacetylase 2 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 |
| Histone deacetylase 8 | NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 4.926546368 | Actual | 4.926546368 | 13 | 0.769230769 | 9 | CREB-binding protein, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Histone deacetylase 8 | 5.238705928 | 5435.619048 | 0.689672696 | 134 | 0.067164179 | 48920.57143 |
| Histone deacetylase 3 | NR1D1 (REV-ERBA) represses gene expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 2 | Histone deacetylase, Histone deacetylase 3 | 5.383512152 | 5190 | 0.670542262 | 6 | 0.333333333 | 10380 |
| 26S proteosome | Orc1 removal from chromatin | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366851786 | 5279.115385 | 0.961538462 | 1119 | 0.006255585 | 36953.80769 |
| Proteasome Macropain subunit MB1 | Orc1 removal from chromatin | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366851786 | 5279.115385 | 0.961538462 | 1119 | 0.006255585 | 36953.80769 |
| Proteasome subunit beta type-7 | Orc1 removal from chromatin | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366851786 | 5279.115385 | 0.961538462 | 1119 | 0.006255585 | 36953.80769 |
| Cannabinoid CB1 receptor/orexin receptor 1 complex | Orexin and neuropeptides FF and QRFP bind to their respective receptors | Homo sapiens | membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor | chemblRecordsPrediction | 5.933538486 | Prediction | 5.933538486 | 72 | 0.722222222 | 3 | Cannabinoid CB1 receptor/orexin receptor 1 complex, Orexin receptor 1, Orexin receptor 2 | 5.392159498 | 25.33333333 | 0.907407407 | 58 | 0.051724138 | 76 |
| 26S proteosome | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 732 | 0.008196721 | 34302.25 |
| Proteasome Macropain subunit MB1 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 732 | 0.008196721 | 34302.25 |
| Proteasome subunit beta type-7 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 732 | 0.008196721 | 34302.25 |
| Histone deacetylase 3 | p75NTR negatively regulates cell cycle via SC1 | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 5 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3 | 5.52587657 | 3897.75 | 0.770473886 | 12 | 0.416666667 | 19488.75 |
| Histone deacetylase 1 | p75NTR negatively regulates cell cycle via SC1 | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 5 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3 | 5.52587657 | 3897.75 | 0.770473886 | 12 | 0.416666667 | 19488.75 |
| Histone deacetylase 2 | p75NTR negatively regulates cell cycle via SC1 | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 5 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3 | 5.52587657 | 3897.75 | 0.770473886 | 12 | 0.416666667 | 19488.75 |
| Somatostatin receptor | Peptide ligand-binding receptors | Homo sapiens | enzyme protease metallo mae m13, ion channel other toxin, membrane receptor 7tm1 peptide protease-activated receptor, membrane receptor 7tm1 peptide protease-activated receptor protease-activated receptor, membrane receptor 7tm1 peptide short peptide galanin receptor, membrane receptor 7tm1 peptide short peptide opioid receptor, membrane receptor 7tm1 peptide short peptide somatostatin receptor, unclassified | chemblRecordsActualValues | 8.66 | Actual | 8.66 | 25 | 1 | 7 | Endothelin-converting enzyme 1, Galanin receptor 2, Kininogen-1, Opioid receptors; delta & kappa, Proenkephalin B, Proteinase-activated receptor 2, Somatostatin receptor | 7.720800998 | 50.91666667 | 0.847201857 | 1026 | 0.006822612 | 356.4166667 |
| Tyrosine aminotransferase | Phenylalanine and tyrosine catabolism | Homo sapiens | enzyme | chemblRecordsPrediction | 6.033998098 | Prediction | 6.033998098 | 27 | 0.703703704 | 1 | Tyrosine aminotransferase | 6.033998098 | 27 | 0.703703704 | 206 | 0.004854369 | 27 |
| Heat shock protein HSP90 | PIWI-interacting RNA (piRNA) biogenesis | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 58 | 0.034482759 | 288 |
| Tubulin | Platelet degranulation | Homo sapiens | adhesion, enzyme protease serine pas s1a, membrane receptor, structural, unclassified | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 7 | Cofilin-1, Fibronectin, Integrin alpha-V/beta-3, Kininogen-1, Plasminogen, Tubulin, von Willebrand factor | 6.231365403 | 8795.571429 | 0.770119114 | 2275 | 0.003076923 | 61569 |
| Tubulin | Post-chaperonin tubulin folding pathway | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.665303734 | 49895.625 | 0.896417143 | 27 | 0.148148148 | 199582.5 |
| Tubulin beta-1 chain | Post-chaperonin tubulin folding pathway | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.665303734 | 49895.625 | 0.896417143 | 27 | 0.148148148 | 199582.5 |
| Protein disulfide-isomerase | Post-translational protein phosphorylation | Homo sapiens | adhesion, cytosolic other, enzyme, enzyme protease serine pas s1a, secreted, unclassified | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 5 | Coagulation factor X/antithrombin III, Fibronectin, Galectin-1, Kininogen-1, Protein disulfide-isomerase | 6.232243012 | 54 | 0.6761455 | 1589 | 0.003146633 | 270 |
| Histone deacetylase 3 | PPARA activates gene expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, epigenetic regulator writer hat src | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 4 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3, Nuclear receptor coactivator 3 | 5.676208462 | 2084.6 | 0.645489632 | 124 | 0.032258065 | 8338.4 |
| Tubulin | Prefoldin mediated transfer of substrate to CCT/TriC | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.695145047 | 48250.85714 | 0.898262104 | 34 | 0.117647059 | 193003.4286 |
| Tubulin beta-1 chain | Prefoldin mediated transfer of substrate to CCT/TriC | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.695145047 | 48250.85714 | 0.898262104 | 34 | 0.117647059 | 193003.4286 |
| Casein kinase II alpha/beta | Receptor Mediated Mitophagy | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 1 | Casein kinase II alpha/beta | 8 | 16 | 0.75 | 129 | 0.007751938 | 16 |
| Tubulin | Recruitment of mitotic centrosome proteins and complexes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 990 | 0.004040404 | 153667.5 |
| Heat shock protein HSP90 | Recruitment of mitotic centrosome proteins and complexes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 990 | 0.004040404 | 153667.5 |
| Tubulin | Recruitment of NuMA to mitotic centrosomes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 6 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.596141818 | 46071.8 | 0.880724341 | 1022 | 0.005870841 | 276430.8 |
| Heat shock protein HSP90 | Recruitment of NuMA to mitotic centrosomes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 6 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.596141818 | 46071.8 | 0.880724341 | 1022 | 0.005870841 | 276430.8 |
| Tubulin beta-1 chain | Recruitment of NuMA to mitotic centrosomes | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 6 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.596141818 | 46071.8 | 0.880724341 | 1022 | 0.005870841 | 276430.8 |
| Tubulin | Recycling pathway of L1 | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 5 | Mitogen-activated protein kinase; ERK1/ERK2, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.634358531 | 49128.17143 | 0.884352955 | 340 | 0.014705882 | 245640.8571 |
| Tubulin beta-1 chain | Recycling pathway of L1 | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 5 | Mitogen-activated protein kinase; ERK1/ERK2, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.634358531 | 49128.17143 | 0.884352955 | 340 | 0.014705882 | 245640.8571 |
| Heat shock protein HSP90 | Regulation of actin dynamics for phagocytic cup formation | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc mapk erk, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 6 | Cofilin-1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Low affinity immunoglobulin gamma Fc region receptor II-a, Mitogen-activated protein kinase; ERK1/ERK2 | 5.022215974 | 69.375 | 0.736810476 | 1123 | 0.005342832 | 416.25 |
| Heat shock protein HSP 90-beta | Regulation of actin dynamics for phagocytic cup formation | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc mapk erk, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 6 | Cofilin-1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Low affinity immunoglobulin gamma Fc region receptor II-a, Mitogen-activated protein kinase; ERK1/ERK2 | 5.022215974 | 69.375 | 0.736810476 | 1123 | 0.005342832 | 416.25 |
| 26S proteosome | Regulation of activated PAK-2p34 by proteasome mediated degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 50 | 0.12 | 34302.25 |
| Proteasome Macropain subunit MB1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 50 | 0.12 | 34302.25 |
| Proteasome subunit beta type-7 | Regulation of activated PAK-2p34 by proteasome mediated degradation | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 50 | 0.12 | 34302.25 |
| Protein disulfide-isomerase | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | Homo sapiens | adhesion, cytosolic other, enzyme, enzyme protease serine pas s1a, enzyme protease serine pas s1a, secreted, unclassified | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 7 | Coagulation factor X/antithrombin III, Fibronectin, Galectin-1, Kininogen-1, Plasminogen, Prostate specific antigen, Protein disulfide-isomerase | 6.133861552 | 50.14285714 | 0.710809173 | 1750 | 0.004 | 351 |
| Histone deacetylase 3 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 3 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3 | 5.528591435 | 3465.333333 | 0.655361508 | 253 | 0.011857708 | 10396 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | Regulation of necroptotic cell death | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 2 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 6.110255909 | 131.5 | 0.664219285 | 66 | 0.03030303 | 263 |
| 26S proteosome | Regulation of ornithine decarboxylase (ODC) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 645 | 0.009302326 | 34302.25 |
| Proteasome Macropain subunit MB1 | Regulation of ornithine decarboxylase (ODC) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 645 | 0.009302326 | 34302.25 |
| Proteasome subunit beta type-7 | Regulation of ornithine decarboxylase (ODC) | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 645 | 0.009302326 | 34302.25 |
| Tubulin | Regulation of PLK1 Activity at G2/M Transition | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 1109 | 0.003606853 | 153667.5 |
| Heat shock protein HSP90 | Regulation of PLK1 Activity at G2/M Transition | Homo sapiens | cytosolic other, structural | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Tubulin, Tubulin beta-2 chain | 5.467827434 | 38416.875 | 0.865289973 | 1109 | 0.003606853 | 153667.5 |
| Histone deacetylase 3 | Regulation of PTEN gene transcription | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Mitogen-activated protein kinase; ERK1/ERK2 | 5.282199507 | 3994.846154 | 0.685952977 | 542 | 0.012915129 | 27963.92308 |
| Histone deacetylase 1 | Regulation of PTEN gene transcription | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Mitogen-activated protein kinase; ERK1/ERK2 | 5.282199507 | 3994.846154 | 0.685952977 | 542 | 0.012915129 | 27963.92308 |
| Histone deacetylase 7 | Regulation of PTEN gene transcription | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia | chemblRecordsActualValues | Actual | 4.212371251 | 8 | 0.75 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Mitogen-activated protein kinase; ERK1/ERK2 | 5.282199507 | 3994.846154 | 0.685952977 | 542 | 0.012915129 | 27963.92308 | |
| Histone deacetylase 2 | Regulation of PTEN gene transcription | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator eraser hdac hdac class iia | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 7 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 5, Mitogen-activated protein kinase; ERK1/ERK2 | 5.282199507 | 3994.846154 | 0.685952977 | 542 | 0.012915129 | 27963.92308 |
| 26S proteosome | Regulation of PTEN stability and activity | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Casein kinase II alpha/beta, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.491845817 | 5278.5 | 0.980769231 | 957 | 0.007314525 | 36949.5 |
| Proteasome Macropain subunit MB1 | Regulation of PTEN stability and activity | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Casein kinase II alpha/beta, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.491845817 | 5278.5 | 0.980769231 | 957 | 0.007314525 | 36949.5 |
| Casein kinase II alpha/beta | Regulation of PTEN stability and activity | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 7 | 26S proteosome, Casein kinase II alpha/beta, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.491845817 | 5278.5 | 0.980769231 | 957 | 0.007314525 | 36949.5 |
| Proteasome subunit beta type-7 | Regulation of PTEN stability and activity | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Casein kinase II alpha/beta, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.491845817 | 5278.5 | 0.980769231 | 957 | 0.007314525 | 36949.5 |
| 26S proteosome | Regulation of RAS by GAPs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 850 | 0.007058824 | 34302.25 |
| Proteasome Macropain subunit MB1 | Regulation of RAS by GAPs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 850 | 0.007058824 | 34302.25 |
| Proteasome subunit beta type-7 | Regulation of RAS by GAPs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 850 | 0.007058824 | 34302.25 |
| 26S proteosome | Regulation of RUNX3 expression and activity | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 749 | 0.008010681 | 33482.45455 |
| Proteasome Macropain subunit MB1 | Regulation of RUNX3 expression and activity | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 749 | 0.008010681 | 33482.45455 |
| Proteasome subunit beta type-7 | Regulation of RUNX3 expression and activity | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376635966 | 5580.409091 | 1 | 749 | 0.008010681 | 33482.45455 |
| Toll-like receptor 4/MD-2 | Regulation of TLR by endogenous ligand | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 246 | 0.008130081 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | Regulation of TLR by endogenous ligand | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 246 | 0.008130081 | 106.8 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | Regulation of TNFR1 signaling | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 2 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 6.110255909 | 131.5 | 0.664219285 | 325 | 0.006153846 | 263 |
| Histone deacetylase 1 | Regulation of TP53 Activity through Acetylation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 211 | 0.018957346 | 13868 |
| Histone deacetylase 2 | Regulation of TP53 Activity through Acetylation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 211 | 0.018957346 | 13868 |
| Casein kinase II alpha/beta | Regulation of TP53 Activity through Phosphorylation | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme kinase protein kinase cmgc mapk p38, enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 3 | CDK2/Cyclin A1, Casein kinase II alpha/beta, MAP kinase p38 | 6.315222821 | 66.66666667 | 0.616666667 | 964 | 0.003112033 | 200 |
| Histone deacetylase 1 | Repression of WNT target genes | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 3 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.622985308 | 3471.666667 | 0.814049451 | 105 | 0.028571429 | 10415 |
| Tubulin | Resolution of Sister Chromatid Cohesion | Homo sapiens | enzyme phosphatase protein phosphatase reg, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 5 | Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.895255979 | 47763.44444 | 0.901454262 | 1418 | 0.003526093 | 238817.2222 |
| Tubulin beta-1 chain | Resolution of Sister Chromatid Cohesion | Homo sapiens | enzyme phosphatase protein phosphatase reg, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 5 | Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.895255979 | 47763.44444 | 0.901454262 | 1418 | 0.003526093 | 238817.2222 |
| Tubulin | RHO GTPases Activate Formins | Homo sapiens | enzyme phosphatase protein phosphatase reg, membrane receptor, structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 6 | Integrin alpha1/beta1 complex, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.978663559 | 45249.78947 | 0.90664088 | 1414 | 0.004243281 | 271498.7368 |
| Tubulin beta-1 chain | RHO GTPases Activate Formins | Homo sapiens | enzyme phosphatase protein phosphatase reg, membrane receptor, structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 6 | Integrin alpha1/beta1 complex, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.978663559 | 45249.78947 | 0.90664088 | 1414 | 0.004243281 | 271498.7368 |
| Tubulin | RHO GTPases activate IQGAPs | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 181 | 0.022099448 | 202291.5294 |
| Tubulin beta-1 chain | RHO GTPases activate IQGAPs | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 181 | 0.022099448 | 202291.5294 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | RIPK1-mediated regulated necrosis | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 2 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 6.110255909 | 131.5 | 0.664219285 | 167 | 0.011976048 | 263 |
| Histone deacetylase 1 | RNA Polymerase I Transcription Initiation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 537 | 0.00744879 | 13868 |
| Histone deacetylase 2 | RNA Polymerase I Transcription Initiation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.573331376 | 3467 | 0.803784427 | 537 | 0.00744879 | 13868 |
| Histone deacetylase 3 | RORA activates gene expression | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 3 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3 | 5.470559721 | 4155.2 | 0.661433809 | 36 | 0.083333333 | 12465.6 |
| Casein kinase II alpha/beta | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 1 | Casein kinase II alpha/beta | 8 | 16 | 0.75 | 505 | 0.001980198 | 16 |
| Histone deacetylase 1 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 3 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.622985308 | 3471.666667 | 0.814049451 | 438 | 0.006849315 | 10415 |
| 26S proteosome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Rhombotin-2 | 6.41311965 | 5488.4 | 1 | 897 | 0.00780379 | 38418.8 |
| Proteasome Macropain subunit MB1 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Rhombotin-2 | 6.41311965 | 5488.4 | 1 | 897 | 0.00780379 | 38418.8 |
| Proteasome subunit beta type-7 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Rhombotin-2 | 6.41311965 | 5488.4 | 1 | 897 | 0.00780379 | 38418.8 |
| Histone deacetylase 4 | RUNX3 regulates p14-ARF | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | Actual | 4.026986893 | 18 | 0.888888889 | 1 | Histone deacetylase | 5.025864087 | 10364 | 0.591084523 | 142 | 0.007042254 | 10364 | |
| Heat shock protein HSP90 | Scavenging by Class F Receptors | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 11 | 0.181818182 | 288 |
| 26S proteosome | SCF(Skp2)-mediated degradation of p27/p21 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376506102 | 5117.375 | 0.958333333 | 626 | 0.011182109 | 35821.625 |
| Proteasome Macropain subunit MB1 | SCF(Skp2)-mediated degradation of p27/p21 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376506102 | 5117.375 | 0.958333333 | 626 | 0.011182109 | 35821.625 |
| Proteasome subunit beta type-7 | SCF(Skp2)-mediated degradation of p27/p21 | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 7 | 26S proteosome, CDK2/Cyclin A1, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.376506102 | 5117.375 | 0.958333333 | 626 | 0.011182109 | 35821.625 |
| 26S proteosome | SCF-beta-TrCP mediated degradation of Emi1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 455 | 0.013186813 | 34302.25 |
| Proteasome Macropain subunit MB1 | SCF-beta-TrCP mediated degradation of Emi1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 455 | 0.013186813 | 34302.25 |
| Proteasome subunit beta type-7 | SCF-beta-TrCP mediated degradation of Emi1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 455 | 0.013186813 | 34302.25 |
| Heat shock protein HSP90 | Sema3A PAK dependent Axon repulsion | Homo sapiens | cytosolic other, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 4 | Cofilin-1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.051545559 | 107.6 | 0.778896761 | 210 | 0.019047619 | 430.4 |
| Heat shock protein HSP 90-beta | Sema3A PAK dependent Axon repulsion | Homo sapiens | cytosolic other, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 4 | Cofilin-1, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.051545559 | 107.6 | 0.778896761 | 210 | 0.019047619 | 430.4 |
| 26S proteosome | Separation of Sister Chromatids | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 11 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 6.164347592 | 23736.92857 | 0.957766112 | 1920 | 0.005729167 | 261106.2143 |
| Tubulin | Separation of Sister Chromatids | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 11 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 6.164347592 | 23736.92857 | 0.957766112 | 1920 | 0.005729167 | 261106.2143 |
| Proteasome Macropain subunit MB1 | Separation of Sister Chromatids | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 11 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 6.164347592 | 23736.92857 | 0.957766112 | 1920 | 0.005729167 | 261106.2143 |
| Proteasome subunit beta type-7 | Separation of Sister Chromatids | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 11 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 6.164347592 | 23736.92857 | 0.957766112 | 1920 | 0.005729167 | 261106.2143 |
| Tubulin beta-1 chain | Separation of Sister Chromatids | Homo sapiens | enzyme phosphatase protein phosphatase reg, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 11 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 6.164347592 | 23736.92857 | 0.957766112 | 1920 | 0.005729167 | 261106.2143 |
| Casein kinase II alpha/beta | Signal transduction by L1 | Homo sapiens | enzyme kinase protein kinase cmgc mapk erk, enzyme kinase protein kinase other ck2, enzyme kinase reg, membrane receptor | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 4 | Casein kinase II alpha/beta, Integrin alpha-V/beta-3, Integrin alpha1/beta1 complex, Mitogen-activated protein kinase; ERK1/ERK2 | 6.917142857 | 8.571428571 | 0.785714286 | 382 | 0.010471204 | 34.28571429 |
| Heat shock protein HSP90 | Signaling by ERBB2 | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 232 | 0.00862069 | 288 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | Signaling by Retinoic Acid | Homo sapiens | auxiliary transport protein fabp, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 1 | Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 5 | 36 | 0.777777778 | 320 | 0.003125 | 36 |
| Histone deacetylase 1 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Homo sapiens | enzyme kinase protein kinase cmgc cdk cdk9, unclassified, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | CDK9/Cyclin K, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 6.224732517 | 2087.8 | 0.755096337 | 369 | 0.010840108 | 8351.2 |
| Histone deacetylase 4 | SUMOylation of chromatin organization proteins | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | Actual | 4.026986893 | 18 | 0.888888889 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.495121763 | 4452.285714 | 0.773398726 | 802 | 0.004987531 | 17809.14286 | |
| Histone deacetylase 1 | SUMOylation of chromatin organization proteins | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.495121763 | 4452.285714 | 0.773398726 | 802 | 0.004987531 | 17809.14286 |
| Histone deacetylase 2 | SUMOylation of chromatin organization proteins | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 5.845168244 | Actual | 5.845168244 | 19 | 0.789473684 | 4 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Histone deacetylase 2 | 5.495121763 | 4452.285714 | 0.773398726 | 802 | 0.004987531 | 17809.14286 |
| Histone deacetylase 7 | SUMOylation of DNA damage response and repair proteins | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | Actual | 4.212371251 | 8 | 0.75 | 1 | Histone deacetylase | 5.025864087 | 10364 | 0.591084523 | 892 | 0.001121076 | 10364 | |
| DNA topoisomerase I | SUMOylation of DNA replication proteins | Homo sapiens | enzyme isomerase | chemblRecordsActualValues | 4.986142007 | Actual | 4.986142007 | 226 | 0.853982301 | 2 | DNA topoisomerase I, DNA topoisomerase II | 4.989307781 | 132.25 | 0.814980724 | 407 | 0.004914005 | 264.5 |
| DNA topoisomerase II | SUMOylation of DNA replication proteins | Homo sapiens | enzyme isomerase | chemblRecordsActualValues | 4.990363039 | Actual | 4.990363039 | 101 | 0.801980198 | 2 | DNA topoisomerase I, DNA topoisomerase II | 4.989307781 | 132.25 | 0.814980724 | 407 | 0.004914005 | 264.5 |
| Casein kinase II alpha/beta | Synthesis of PC | Homo sapiens | enzyme, enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 2 | Casein kinase II alpha/beta, Choline/ethanolamine kinase | 6.886666667 | 11 | 0.833333333 | 448 | 0.004464286 | 22 |
| Heat shock protein HSP90 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Homo sapiens | cytosolic other, enzyme reductase | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 3 | Dihydrofolate reductase, Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.802802598 | 258.6666667 | 0.699006936 | 140 | 0.021428571 | 776 |
| Heat shock protein HSP90 | The NLRP3 inflammasome | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 4.946290134 | 123 | 0.944838057 | 329 | 0.006079027 | 246 |
| Heat shock protein HSP 90-beta | The NLRP3 inflammasome | Homo sapiens | cytosolic other | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 2 | Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 4.946290134 | 123 | 0.944838057 | 329 | 0.006079027 | 246 |
| 26S proteosome | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Tubulin | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Heat shock protein HSP90 | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Heat shock protein HSP 90-beta | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Proteasome Macropain subunit MB1 | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Proteasome subunit beta type-7 | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Tubulin beta-1 chain | The role of GTSE1 in G2/M progression after G2 checkpoint | Homo sapiens | cytosolic other, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, structural, unclassified | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 13 | 26S proteosome, Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8, Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.981044297 | 22166.26667 | 0.947125789 | 587 | 0.022146508 | 288161.4667 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 2 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 6.110255909 | 131.5 | 0.664219285 | 157 | 0.012738854 | 263 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | TNFR1-induced NFkappaB signaling pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 2 | Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | 6.110255909 | 131.5 | 0.664219285 | 290 | 0.006896552 | 263 |
| 26S proteosome | TNFR2 non-canonical NF-kB pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 8 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.346480887 | 5287.384615 | 0.974170714 | 885 | 0.009039548 | 42299.07692 |
| Proteasome Macropain subunit MB1 | TNFR2 non-canonical NF-kB pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 8 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.346480887 | 5287.384615 | 0.974170714 | 885 | 0.009039548 | 42299.07692 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | TNFR2 non-canonical NF-kB pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 8 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.346480887 | 5287.384615 | 0.974170714 | 885 | 0.009039548 | 42299.07692 |
| Proteasome subunit beta type-7 | TNFR2 non-canonical NF-kB pathway | Homo sapiens | auxiliary transport protein fabp, enzyme, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 8 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.346480887 | 5287.384615 | 0.974170714 | 885 | 0.009039548 | 42299.07692 |
| Toll-like receptor 4/MD-2 | Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens | membrane receptor, membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 3 | Integrin alpha M, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.007356417 | 46.5 | 0.958333333 | 173 | 0.01734104 | 139.5 |
| Toll-like receptor 4/MD-2/CD14 | Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens | membrane receptor, membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 3 | Integrin alpha M, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.007356417 | 46.5 | 0.958333333 | 173 | 0.01734104 | 139.5 |
| Integrin alpha M | Toll Like Receptor 4 (TLR4) Cascade | Homo sapiens | membrane receptor, membrane receptor, surface antigen | chemblRecordsPrediction | 5.044138505 | Prediction | 5.044138505 | 12 | 0.75 | 3 | Integrin alpha M, Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5.007356417 | 46.5 | 0.958333333 | 173 | 0.01734104 | 139.5 |
| Toll-like receptor 4/MD-2/CD14 | Toll Like Receptor TLR1:TLR2 Cascade | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 1 | Toll-like receptor 4/MD-2/CD14 | 5 | 9 | 1 | 7 | 0.142857143 | 9 |
| Toll-like receptor 4/MD-2/CD14 | Toll Like Receptor TLR6:TLR2 Cascade | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 1 | Toll-like receptor 4/MD-2/CD14 | 5 | 9 | 1 | 4 | 0.25 | 9 |
| Toll-like receptor 4/MD-2 | TRAF6 mediated induction of TAK1 complex | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 67 | 0.029850746 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | TRAF6 mediated induction of TAK1 complex | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 67 | 0.029850746 | 106.8 |
| DNA topoisomerase II | Transcription of E2F targets under negative control by DREAM complex | Homo sapiens | enzyme isomerase, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 4.990363039 | Actual | 4.990363039 | 101 | 0.801980198 | 4 | DNA topoisomerase II, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.464829741 | 2629 | 0.811032138 | 27 | 0.148148148 | 10516 |
| Histone deacetylase 1 | Transcription of E2F targets under negative control by DREAM complex | Homo sapiens | enzyme isomerase, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 4 | DNA topoisomerase II, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.464829741 | 2629 | 0.811032138 | 27 | 0.148148148 | 10516 |
| Histone deacetylase 1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv | chemblRecordsActualValues | 6.143091837 | Actual | 6.143091837 | 47 | 0.85106383 | 3 | Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1 | 5.622985308 | 3471.666667 | 0.814049451 | 27 | 0.111111111 | 10415 |
| Histone deacetylase 3 | Transcriptional activation of mitochondrial biogenesis | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 3 | CREB-binding protein, Histone deacetylase, Histone deacetylase 3 | 5.528591435 | 3465.333333 | 0.655361508 | 219 | 0.01369863 | 10396 |
| Histone deacetylase 3 | Transcriptional regulation of white adipocyte differentiation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, epigenetic regulator writer hat src, transcription factor, transcription factor nuclear receptor nr2 nr2f nr2f2, unclassified | chemblRecordsActualValues | 5.741160217 | Actual | 5.741160217 | 16 | 0.75 | 7 | COUP transcription factor 2, CREB-binding protein, Histone deacetylase, Histone deacetylase 3, Kruppel-like factor 5, Nuclear factor NF-kappa-B p65 subunit, Nuclear receptor coactivator 3 | 5.785759747 | 1893.909091 | 0.692869362 | 168 | 0.041666667 | 13257.36364 |
| COUP transcription factor 2 | Transcriptional regulation of white adipocyte differentiation | Homo sapiens | epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, epigenetic regulator writer hat src, transcription factor, transcription factor nuclear receptor nr2 nr2f nr2f2, unclassified | chemblRecordsActualValues | 6.289952038 | Actual | 6.289952038 | 6 | 0.833333333 | 7 | COUP transcription factor 2, CREB-binding protein, Histone deacetylase, Histone deacetylase 3, Kruppel-like factor 5, Nuclear factor NF-kappa-B p65 subunit, Nuclear receptor coactivator 3 | 5.785759747 | 1893.909091 | 0.692869362 | 168 | 0.041666667 | 13257.36364 |
| Toll-like receptor 4/MD-2/CD14 | Transfer of LPS from LBP carrier to CD14 | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 1 | Toll-like receptor 4/MD-2/CD14 | 5 | 9 | 1 | 18 | 0.055555556 | 9 |
| Tubulin | Translocation of GLUT4 to the plasma membrane | Homo sapiens | structural | chemblRecordsActualValues | 5.456414547 | Actual | 5.456414547 | 61409 | 0.883502418 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 330 | 0.012121212 | 202291.5294 |
| Tubulin beta-1 chain | Translocation of GLUT4 to the plasma membrane | Homo sapiens | structural | chemblRecordsActualValues | 5.448571429 | Actual | 5.448571429 | 7 | 0.857142857 | 4 | Tubulin, Tubulin beta-1 chain, Tubulin beta-2 chain, Tubulin beta-3 chain | 5.653016135 | 50572.88235 | 0.895657454 | 330 | 0.012121212 | 202291.5294 |
| Toll-like receptor 4/MD-2 | TRIF-mediated programmed cell death | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 120 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 10 | 0.2 | 106.8 |
| Toll-like receptor 4/MD-2/CD14 | TRIF-mediated programmed cell death | Homo sapiens | membrane receptor, surface antigen | chemblRecordsPrediction | 5 | Prediction | 5 | 9 | 1 | 2 | Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14 | 5 | 53.4 | 1 | 10 | 0.2 | 106.8 |
| 26S proteosome | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 824 | 0.007281553 | 34302.25 |
| Proteasome Macropain subunit MB1 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 824 | 0.007281553 | 34302.25 |
| Proteasome subunit beta type-7 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 824 | 0.007281553 | 34302.25 |
| 26S proteosome | Ubiquitin-dependent degradation of Cyclin D1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 729 | 0.008230453 | 34302.25 |
| Proteasome Macropain subunit MB1 | Ubiquitin-dependent degradation of Cyclin D1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 729 | 0.008230453 | 34302.25 |
| Proteasome subunit beta type-7 | Ubiquitin-dependent degradation of Cyclin D1 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 729 | 0.008230453 | 34302.25 |
| 26S proteosome | Ub-specific processing proteases | Homo sapiens | auxiliary transport protein fabp, enzyme, cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 9 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, CDK2/Cyclin A1, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.347540025 | 5092.444444 | 0.956608836 | 2743 | 0.003281079 | 45832 |
| Proteasome Macropain subunit MB1 | Ub-specific processing proteases | Homo sapiens | auxiliary transport protein fabp, enzyme, cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 9 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, CDK2/Cyclin A1, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.347540025 | 5092.444444 | 0.956608836 | 2743 | 0.003281079 | 45832 |
| Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins | Ub-specific processing proteases | Homo sapiens | auxiliary transport protein fabp, enzyme, cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 5 | Prediction | 5 | 36 | 0.777777778 | 9 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, CDK2/Cyclin A1, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.347540025 | 5092.444444 | 0.956608836 | 2743 | 0.003281079 | 45832 |
| Proteasome subunit beta type-7 | Ub-specific processing proteases | Homo sapiens | auxiliary transport protein fabp, enzyme, cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 9 | 26S proteosome, Baculoviral IAP repeat-containing protein 3, CDK2/Cyclin A1, Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.347540025 | 5092.444444 | 0.956608836 | 2743 | 0.003281079 | 45832 |
| 26S proteosome | UCH proteinases | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1436 | 0.004178273 | 34302.25 |
| Proteasome Macropain subunit MB1 | UCH proteinases | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1436 | 0.004178273 | 34302.25 |
| Proteasome subunit beta type-7 | UCH proteinases | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 1436 | 0.004178273 | 34302.25 |
| Heat shock protein HSP90 | Uptake and function of diphtheria toxin | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 3 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.064431948 | 133.5 | 0.848620951 | 7 | 0.428571429 | 400.5 |
| Heat shock protein HSP 90-beta | Uptake and function of diphtheria toxin | Homo sapiens | cytosolic other | chemblRecordsActualValues | 5.460794139 | Actual | 5.460794139 | 38 | 0.947368421 | 3 | Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-beta, Heat shock protein HSP90 | 5.064431948 | 133.5 | 0.848620951 | 7 | 0.428571429 | 400.5 |
| Arginase-1 | Urea cycle | Homo sapiens | enzyme | chemblRecordsPrediction | 6.126875 | Prediction | 6.126875 | 64 | 0.84375 | 2 | Arginase-1, Arginase-2- mitochondrial | 6.168845663 | 56.5 | 0.921875 | 149 | 0.013422819 | 113 |
| Arginase-2- mitochondrial | Urea cycle | Homo sapiens | enzyme | chemblRecordsPrediction | 6.210816327 | Prediction | 6.210816327 | 49 | 1 | 2 | Arginase-1, Arginase-2- mitochondrial | 6.168845663 | 56.5 | 0.921875 | 149 | 0.013422819 | 113 |
| Placenta growth factor | VEGF binds to VEGFR leading to receptor dimerization | Homo sapiens | unclassified | chemblRecordsPrediction | 6.957936508 | Prediction | 6.957936508 | 63 | 0.825396825 | 1 | Placenta growth factor | 6.957936508 | 63 | 0.825396825 | 99 | 0.01010101 | 63 |
| Placenta growth factor | VEGF ligand-receptor interactions | Homo sapiens | unclassified | chemblRecordsPrediction | 6.957936508 | Prediction | 6.957936508 | 63 | 0.825396825 | 1 | Placenta growth factor | 6.957936508 | 63 | 0.825396825 | 62 | 0.016129032 | 63 |
| Heat shock protein HSP90 | VEGFA-VEGFR2 Pathway | Homo sapiens | cytosolic other, enzyme kinase protein kinase cmgc mapk p38, enzyme, unclassified, membrane receptor | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 6 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90, Integrin alpha-V/beta-3, MAP kinase p38, PI3-kinase class I, Src homology 2 domain containing transforming protein C2 | 5.951087275 | 11624.89474 | 0.719141823 | 899 | 0.006674082 | 69749.36842 |
| Heat shock protein HSP90 | VEGFR2 mediated vascular permeability | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 342 | 0.005847953 | 288 |
| 26S proteosome | Vif-mediated degradation of APOBEC3G | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Proteasome Macropain subunit MB1 | Vif-mediated degradation of APOBEC3G | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Proteasome subunit beta type-7 | Vif-mediated degradation of APOBEC3G | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 56 | 0.107142857 | 34302.25 |
| Protein disulfide-isomerase | VLDL assembly | Homo sapiens | enzyme | chemblRecordsActualValues | 5.16416382 | Actual | 5.16416382 | 9 | 0.777777778 | 1 | Protein disulfide-isomerase | 5.16416382 | 9 | 0.777777778 | 50 | 0.02 | 9 |
| 26S proteosome | Vpu mediated degradation of CD4 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 6.251 | Actual | 6.251 | 7220 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 53 | 0.113207547 | 34302.25 |
| Proteasome Macropain subunit MB1 | Vpu mediated degradation of CD4 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsActualValues | 7.703082613 | Actual | 7.703082613 | 11 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 53 | 0.113207547 | 34302.25 |
| Proteasome subunit beta type-7 | Vpu mediated degradation of CD4 | Homo sapiens | enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, unclassified | chemblRecordsPrediction | 7.698970004 | Prediction | 7.698970004 | 8 | 1 | 6 | 26S proteosome, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8 | 6.366166302 | 5717.041667 | 1 | 53 | 0.113207547 | 34302.25 |
| Heat shock protein HSP90 | vRNP Assembly | Homo sapiens | cytosolic other | chemblRecordsActualValues | 4.43178613 | Actual | 4.43178613 | 208 | 0.942307692 | 2 | Heat shock protein HSP 90-alpha, Heat shock protein HSP90 | 5.182573762 | 144 | 0.752403846 | 6 | 0.333333333 | 288 |
| Casein kinase II alpha/beta | WNT mediated activation of DVL | Homo sapiens | enzyme kinase protein kinase other ck2, enzyme kinase reg | chemblRecordsPrediction | 8 | Prediction | 8 | 16 | 0.75 | 1 | Casein kinase II alpha/beta | 8 | 16 | 0.75 | 113 | 0.008849558 | 16 |