BrCa graph data table

BrCa selection table with centrality measures

nametypeofnodetargetclassavgchemblscoretargetcountchemblscoretargetcountratiotargetbrcaactivitiesavgchemblscorepathwaycountchemblscorepathwaycountratiopathwaynumberofpathwayproteinswithrecordstotalnumberofproteinsinthepathwayrateproteinswithrecordsvstotalpathwayproteinstargetidentifiedfromeccentricityclosnesscentralityharmonicclosnesscentralitybetweenesscentralitypageranks
Signal attenuationpathwaypathway5.080.55.08.00.511150.008695652Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
EPHB-mediated forward signalingpathwaypathway5.040.55.04.00.516020.00166113Untagged12.00.13386798272671190.15705424887452550.00.0014292794771940834
RHO GTPases Activate WASPs and WAVEspathwaypathway5.080.55.08.00.515470.001828154Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Transferrin endocytosis and recyclingpathwaypathway5.021.05.02.01.014780.00209205Untagged2.00.57142857142857140.6250.00.0017875358290478892
Golgi Cisternae Pericentriolar Stack Reorganizationpathwaypathway5.080.55.08.00.511250.008Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Negative regulation of FGFR3 signalingpathwaypathway5.080.55.08.00.512810.003558719Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
ISG15 antiviral mechanismpathwaypathway5.080.55.08.00.513340.002994012Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Gastrin-CREB signalling pathway via PKC and MAPKpathwaypathway5.080.55.08.00.511460.006849315Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Ion channel transportpathwaypathway5.021.05.02.01.012860.003496503Untagged2.00.57142857142857140.6250.00.0017875358290478892
CREB phosphorylation through the activation of Raspathwaypathway5.080.55.08.00.512560.00390625Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
phospho-PLA2 pathwaypathwaypathway5.080.55.08.00.51290.034482759Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
ROS, RNS production in phagocytespathwaypathway5.021.05.02.01.015180.001930502Untagged2.00.57142857142857140.6250.00.0017875358290478892
Spry regulation of FGF signalingpathwaypathway5.080.55.08.00.511870.005347594Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Heme degradationpathwaypathway5.031.05.03.01.01890.011235955Untagged10.00.167051578137028480.193290542023261570.00.0014613369130400443
Toll Like Receptor TLR1:TLR2 Cascadepathwaypathway5.091.05.09.01.0170.142857143Untagged2.00.60.66666666666666660.00.0018918821757760705
MAPK3 (ERK1) activationpathwaypathway5.080.55.08.00.511410.007092199Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Toll Like Receptor TLR6:TLR2 Cascadepathwaypathway5.091.05.09.01.0140.25Untagged2.00.60.66666666666666660.00.0018918821757760705
Iron uptake and transportpathwaypathway5.031.05.03.01.014690.002132196Untagged10.00.167051578137028480.193290542023261570.00.0014613369130400443
Negative regulation of FGFR1 signalingpathwaypathway5.080.55.08.00.513220.00310559Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Insulin receptor recyclingpathwaypathway5.021.05.02.01.014220.002369668Untagged2.00.57142857142857140.6250.00.0017875358290478892
Negative feedback regulation of MAPK pathwaypathwaypathway5.080.55.08.00.511570.006369427Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
MAPK1 (ERK2) activationpathwaypathway5.080.55.08.00.511360.007352941Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Apoptotic cleavage of cellular proteinspathwaypathway5.0360.7777777785.036.00.77777777812710.003690037Untagged11.00.141184124918672740.166505908326185140.00.0011703467400629608
ERKs are inactivatedpathwaypathway5.080.55.08.00.512220.004504505Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
NCAM signaling for neurite out-growthpathwaypathway5.080.55.08.00.513640.002747253Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Heme biosynthesispathwaypathway5.0110.9090909095.011.00.90909090912140.004672897Untagged1.01.01.00.00.0027266529496015224
RNA Polymerase I Promoter Openingpathwaypathway5.080.55.08.00.51840.011904762Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
RSK activationpathwaypathway5.080.55.08.00.511340.007462687Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationpathwaypathway5.040.55.04.00.51380.026315789Untagged12.00.13386798272671190.15705424887452550.00.0014292794771940834
Negative regulation of FGFR4 signalingpathwaypathway5.080.55.08.00.512960.003378378Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Advanced glycosylation endproduct receptor signalingpathwaypathway5.080.55.08.00.51740.013513514Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Negative regulation of FGFR2 signalingpathwaypathway5.080.55.08.00.513590.002785515Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Transfer of LPS from LBP carrier to CD14pathwaypathway5.091.05.09.01.01180.055555556Untagged2.00.60.66666666666666660.00.0018918821757760705
Thrombin signalling through proteinase activated receptors (PARs)pathwaypathway5.080.55.08.00.512120.004716981Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Signaling by Retinoic Acidpathwaypathway5.0360.7777777785.036.00.77777777813200.003125Untagged11.00.141184124918672740.166505908326185140.00.0011703467400629608
FCERI mediated MAPK activationpathwaypathway5.080.55.08.00.516770.001477105Untagged7.00.28977272727272730.36316526610644240.00.001492922174479484
Elevation of cytosolic Ca2+ levelspathwaypathway5.0076190485670.7619047625.007619048567.00.76190476212010.004975124Untagged12.00.13207547169811320.155223731721427780.00.0016704991731886604
SUMOylation of DNA damage response and repair proteinspathwaypathway5.025864087103640.5910845235.02586408710364.00.59108452318920.001121076Untagged11.00.156452775775054060.2035039333426437340.432692307692260.0019388519616099797
RUNX3 regulates p14-ARFpathwaypathway5.025864087103640.5910845235.02586408710364.00.59108452311420.007042254Untagged11.00.154668567355666420.19674510077735950.09.764295354840718E-4
Platelet Aggregation (Plug Formation)pathwaypathway5.039188911220.6363636365.03918891122.00.6363636361710.014084507Untagged12.00.146720757268424620.185609219249772860.00.0011448392815209746
Detoxification of Reactive Oxygen Speciespathwaypathway5.08208191110.8888888895.0820819111.00.88888888925710.003502627Untagged12.00.134365325077399370.1638459978321733216.00.0026450886369640612
Interleukin-10 signalingpathwaypathway5.10714285770.7142857145.1071428577.00.71428571411090.009174312Untagged10.00.179784589892294950.206618023553508060.00.0013090419171511401
FGFR2 alternative splicingpathwaypathway5.1161.05.116.01.024190.00477327Untagged4.00.40.48611111111111110.00.0016043914932623146
Processing of Capped Intron-Containing Pre-mRNApathwaypathway5.1161.05.116.01.024750.004210526Untagged4.00.40.48611111111111110.00.0016043914932623146
Androgen biosynthesispathwaypathway5.1130.6666666675.113.00.66666666711420.007042254Untagged2.00.60.66666666666666660.00.0018918821757760705
Glucocorticoid biosynthesispathwaypathway5.1130.6666666675.113.00.66666666711120.008928571Untagged2.00.60.66666666666666660.00.0018918821757760705
Mineralocorticoid biosynthesispathwaypathway5.1130.6666666675.113.00.6666666671710.014084507Untagged2.00.60.66666666666666660.00.0018918821757760705
Glycosphingolipid metabolismpathwaypathway5.14598000331.05.1459800033.01.036280.00477707Untagged0.00.00.00.04.0899794244022864E-4
Purine salvagepathwaypathway5.151679919120.5857142865.15167991912.00.58571428622430.008230453Untagged1.01.01.00.00.0027266529496015224
Interleukin-12 family signalingpathwaypathway5.1641638290.7777777785.164163829.00.77777777812300.004347826Untagged12.00.13419913419913420.16077380121158950.00.0013418349964516964
Collagen biosynthesis and modifying enzymespathwaypathway5.1641638290.7777777785.164163829.00.77777777818070.001239157Untagged12.00.13419913419913420.16077380121158950.00.0013418349964516964
Chylomicron assemblypathwaypathway5.1641638290.7777777785.164163829.00.77777777811030.009708738Untagged12.00.13419913419913420.16077380121158950.00.0013418349964516964
VLDL assemblypathwaypathway5.1641638290.7777777785.164163829.00.7777777781500.02Untagged12.00.13419913419913420.16077380121158950.00.0013418349964516964
VEGFR2 mediated vascular permeabilitypathwaypathway5.1825737622880.7524038465.182573762288.00.75240384623420.005847953Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
Scavenging by Class F Receptorspathwaypathway5.1825737622880.7524038465.182573762288.00.7524038462110.181818182Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
EPHA-mediated growth cone collapsepathwaypathway5.1825737622880.7524038465.182573762288.00.75240384623820.005235602Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
Signaling by ERBB2pathwaypathway5.1825737622880.7524038465.182573762288.00.75240384622320.00862069Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
eNOS activationpathwaypathway5.1825737622880.7524038465.182573762288.00.75240384621180.016949153Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
Downregulation of ERBB2 signalingpathwaypathway5.1825737622880.7524038465.182573762288.00.75240384623270.006116208Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
vRNP Assemblypathwaypathway5.1825737622880.7524038465.182573762288.00.752403846260.333333333Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
PIWI-interacting RNA (piRNA) biogenesispathwaypathway5.1825737622880.7524038465.182573762288.00.7524038462580.034482759Untagged8.00.190853122251539140.216683124862848960.00.0013643942200226977
Chromatin modifying enzymespathwaypathway5.18333333351.05.1833333335.01.031070.028037383Untagged0.00.00.00.04.0899794244022864E-4
Growth hormone receptor signalingpathwaypathway5.203333333120.6666666675.20333333312.00.66666666721760.011363636Untagged7.00.296511627906976770.381139122315592798.00.0027837910033156037
Metabolism of Angiotensinogen to Angiotensinspathwaypathway5.23047938640.8333333335.2304793864.00.83333333321480.013513514Untagged2.00.66666666666666660.750.00.0021005748692324343
CLEC7A/inflammasome pathwaypathwaypathway5.256432251220.6547619055.25643225122.00.6547619053450.066666667Untagged10.00.179784589892294950.206618023553508060.00.0013090419171511401
RNF mutants show enhanced WNT signaling and proliferationpathwaypathway5.2666954990.5555555565.266695499.00.555555556180.125Untagged8.00.21250.25427170868347340.00.0014344925990242398
Regulation of FZD by ubiquitinationpathwaypathway5.2666954990.5555555565.266695499.00.55555555611750.005714286Untagged8.00.21250.25427170868347340.00.0014344925990242398
Interleukin-1 processingpathwaypathway5.27798171190.6488095245.2779817119.00.6488095242690.028985507Untagged10.00.179784589892294950.206618023553508060.00.0013090419171511401
Activation of Matrix Metalloproteinasespathwaypathway5.30904095350.8333333335.3090409535.00.83333333324010.004987531Untagged2.00.66666666666666660.750.00.0021005748692324343
Interconversion of nucleotide di- and triphosphatespathwaypathway5.37516409760.6666666675.3751640976.00.66666666715690.001757469Untagged11.00.146720757268424620.167405623050784660.00.0013690441116493116
Association of TriC/CCT with target proteins during biosynthesispathwaypathway5.383512152103800.6705422625.38351215210380.00.67054226222050.009756098Untagged11.00.154889364739471820.199817297397943232.249122807017560.001632664400168809
NR1D1 (REV-ERBA) represses gene expressionpathwaypathway5.383512152103800.6705422625.38351215210380.00.670542262260.333333333Untagged11.00.154889364739471820.199817297397943232.249122807017560.001632664400168809
Orexin and neuropeptides FF and QRFP bind to their respective receptorspathwaypathway5.392159498760.9074074075.39215949876.00.9074074073580.051724138Untagged3.00.57142857142857140.70833333333333333.00.003352731029970611
Amyloid fiber formationpathwaypathway5.41464563721.05.4146456372.01.01710.014084507Untagged1.01.01.00.00.0027266529496015224
mRNA Splicing - Major Pathwaypathwaypathway5.433875618590.8993710695.43387561859.00.899371069331159.63082E-4Untagged2.00.66666666666666660.759.50.003820533100982685
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)pathwaypathway5.448820563120.5833333335.44882056312.00.583333333180.125Untagged0.00.00.00.04.0899794244022864E-4
TRAF6 mediated NF-kB activationpathwaypathway5.448820563120.5833333335.44882056312.00.58333333312080.004807692Untagged0.00.00.00.04.0899794244022864E-4
PKMTs methylate histone lysinespathwaypathway5.448820563120.5833333335.44882056312.00.58333333313900.002564103Untagged13.00.119823302043070120.13912849822988060.00.0016470161266018098
IkBA variant leads to EDA-IDpathwaypathway5.448820563120.5833333335.44882056312.00.583333333170.142857143Untagged0.00.00.00.04.0899794244022864E-4
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathwaypathway5.448820563120.5833333335.44882056312.00.58333333311520.006578947Untagged0.00.00.00.04.0899794244022864E-4
Regulated proteolysis of p75NTRpathwaypathway5.448820563120.5833333335.44882056312.00.5833333331980.010204082Untagged0.00.00.00.04.0899794244022864E-4
NF-kB is activated and signals survivalpathwaypathway5.448820563120.5833333335.44882056312.00.58333333311350.007407407Untagged0.00.00.00.04.0899794244022864E-4
TAK1 activates NFkB by phosphorylation and activation of IKKs complexpathwaypathway5.448820563120.5833333335.44882056312.00.58333333313520.002840909Untagged0.00.00.00.04.0899794244022864E-4
RIP-mediated NFkB activation via ZBP1pathwaypathway5.448820563120.5833333335.44882056312.00.58333333311900.005263158Untagged0.00.00.00.04.0899794244022864E-4
HATs acetylate histonespathwaypathway5.459375170.81255.45937517.00.812525880.003401361Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Transcription of E2F targets under negative control by DREAM complexpathwaypathway5.464829741105160.8110321385.46482974110516.00.8110321384270.148148148Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
BMAL1:CLOCK,NPAS2 activates circadian gene expressionpathwaypathway5.528591435103960.6553615085.52859143510396.00.6553615083670.044776119Untagged11.00.15850986121256390.22017060000931024486.915121136174430.0024742439129721715
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)pathwaypathway5.528591435103960.6553615085.52859143510396.00.65536150832530.011857708Untagged11.00.15850986121256390.22017060000931024486.915121136174430.0024742439129721715
Transcriptional activation of mitochondrial biogenesispathwaypathway5.528591435103960.6553615085.52859143510396.00.65536150832190.01369863Untagged11.00.15850986121256390.22017060000931024486.915121136174430.0024742439129721715
NoRC negatively regulates rRNA expressionpathwaypathway5.573331376138680.8037844275.57333137613868.00.80378442741760.022727273Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
RNA Polymerase I Transcription Initiationpathwaypathway5.573331376138680.8037844275.57333137613868.00.80378442745370.00744879Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
Regulation of TP53 Activity through Acetylationpathwaypathway5.573331376138680.8037844275.57333137613868.00.80378442742110.018957346Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionpathwaypathway5.573331376138680.8037844275.57333137613868.00.8037844274780.051282051Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
Prolactin receptor signalingpathwaypathway5.6121.05.612.01.011250.008Untagged9.00.188888888888888880.222136632430749960.00.0016998667712763483
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1pathwaypathway5.622985308104150.8140494515.62298530810415.00.8140494513270.111111111Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
Downregulation of SMAD2/3:SMAD4 transcriptional activitypathwaypathway5.622985308104150.8140494515.62298530810415.00.81404945133740.00802139Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
Deactivation of the beta-catenin transactivating complexpathwaypathway5.622985308104150.8140494515.62298530810415.00.81404945134520.006637168Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionpathwaypathway5.622985308104150.8140494515.62298530810415.00.81404945134380.006849315Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
Repression of WNT target genespathwaypathway5.622985308104150.8140494515.62298530810415.00.81404945131050.028571429Untagged11.00.155110793423874180.20288949401852692.16430499325236170.0020352362888410623
CD209 (DC-SIGN) signalingpathwaypathway5.633785282280.6041666675.63378528228.00.60416666722900.006896552Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Activation of anterior HOX genes in hindbrain development during early embryogenesispathwaypathway5.640573077104070.650612045.64057307710407.00.6506120441780.02247191Untagged11.00.158741770299926840.22324279662989396702.91512113617430.0034440460960183097
Degradation of the extracellular matrixpathwaypathway5.6469160160.93755.646916016.00.937538830.003397508Untagged10.00.177723177723177720.218899495281984380.00.001123562288537993
Formation of the beta-catenin:TCF transactivating complexpathwaypathway5.671926481104310.7667870885.67192648110431.00.76678708844130.00968523Untagged11.00.158741770299926840.223242796629893961320.88006876164240.002876815801644425
WNT ligand biogenesis and traffickingpathwaypathway5.6775798151510.5348200315.677579815151.00.53482003123120.006410256Untagged8.00.216101694915254240.280415499533146673.50.003773841243687631
Class B/2 (Secretin family receptors)pathwaypathway5.6775798151510.5348200315.677579815151.00.53482003122190.00913242Untagged8.00.216101694915254240.280415499533146673.50.0037738412436876313
Antigen activates B Cell Receptor (BCR) leading to generation of second messengerspathwaypathway5.67987013280230.7093323345.6798701328023.00.70933233424330.004618938Untagged10.00.178895300906842550.24213846829054236430.00.0026801008435565826
GP1b-IX-V activation signallingpathwaypathway5.695655062274780.6465617725.69565506227478.00.64656177221610.01242236Untagged10.00.184680851063829780.2544272547728773496.93967698967660.0021544409518888964
Lysosphingolipid and LPA receptorspathwaypathway5.7421.05.742.01.011040.009615385Untagged1.01.01.00.00.0027266529496015224
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variantspathwaypathway5.767347487414000.7045818765.76734748741400.00.7045818763190.157894737Untagged8.00.20607787274453940.26437897739741073879.65773115773140.0023739958903906196
Constitutive Signaling by EGFRvIIIpathwaypathway5.767347487414000.7045818765.76734748741400.00.7045818763150.2Untagged8.00.20607787274453940.26437897739741073879.65773115773140.0023739958903906196
Rap1 signallingpathwaypathway5.7950.65.795.00.612260.004424779Untagged12.00.13486637663144810.162737812622605530.00.0012475247505132334
MET activates RAP1 and RAC1pathwaypathway5.7950.65.795.00.611790.005586592Untagged12.00.13486637663144810.162737812622605530.00.0012475247505132334
ARMS-mediated activationpathwaypathway5.7950.65.795.00.61750.013333333Untagged12.00.13486637663144810.162737812622605530.00.0012475247505132334
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionpathwaypathway5.7950.65.795.00.614150.002409639Untagged12.00.13486637663144810.162737812622605530.00.0012475247505132334
Frs2-mediated activationpathwaypathway5.7950.65.795.00.611000.01Untagged12.00.13486637663144810.162737812622605530.00.0012475247505132334
Formation of the cornified envelopepathwaypathway5.797751264560.8473205265.79775126456.00.84732052649750.004102564Untagged4.00.50.635416666666666613.00.0044546840083874994
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationpathwaypathway5.8028025987760.6990069365.802802598776.00.69900693631400.021428571Untagged7.00.2234809474768280.247278911564626146573.7181984682220.0022616918199176404
DNA Damage/Telomere Stress Induced Senescencepathwaypathway5.814496172340.6666666675.81449617234.00.66666666723020.006622517Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Activation of gene expression by SREBF (SREBP)pathwaypathway5.81875160.6255.8187516.00.6251490.020408163Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Activation of the TFAP2 (AP-2) family of transcription factorspathwaypathway5.81875160.6255.8187516.00.62511230.008130081Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
TRAF3-dependent IRF activation pathwaypathwaypathway5.81875160.6255.8187516.00.6251710.014084507Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
YAP1- and WWTR1 (TAZ)-stimulated gene expressionpathwaypathway5.81875160.6255.8187516.00.62511290.007751938Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
RUNX3 regulates NOTCH signalingpathwaypathway5.81875160.6255.8187516.00.62511620.00617284Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Pre-NOTCH Transcription and Translationpathwaypathway5.81875160.6255.8187516.00.6251370.027027027Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
RUNX1 regulates transcription of genes involved in differentiation of myeloid cellspathwaypathway5.81875160.6255.8187516.00.6251760.013157895Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionpathwaypathway5.81875160.6255.8187516.00.6251500.02Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
RUNX3 regulates YAP1-mediated transcriptionpathwaypathway5.81875160.6255.8187516.00.6251880.011363636Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
TP53 Regulates Transcription of Genes Involved in Cytochrome C Releasepathwaypathway5.81875160.6255.8187516.00.62511180.008474576Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
TRAF6 mediated IRF7 activationpathwaypathway5.81875160.6255.8187516.00.62511810.005524862Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Regulation of gene expression by Hypoxia-inducible Factorpathwaypathway5.81875160.6255.8187516.00.62511190.008403361Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Notch-HLH transcription pathwaypathwaypathway5.81875160.6255.8187516.00.62511470.006802721Untagged13.00.123505976095617530.166132740787119320.00.0012505774552435912
Ca2+ activated K+ channelspathwaypathway5.83666666760.6666666675.8366666676.00.66666666711450.006896552Untagged1.01.01.00.00.0027266529496015224
Class A/1 (Rhodopsin-like receptors)pathwaypathway5.85843591750.6944444445.8584359175.00.69444444421990.010050251Untagged3.00.57142857142857140.70833333333333333.00.003352731029970611
Muscarinic acetylcholine receptorspathwaypathway5.9378755991040.55.937875599104.00.51580.017241379Untagged1.01.01.00.00.0027266529496015224
Activation of E2F1 target genes at G1/Spathwaypathway5.94374298109330.7001713565.9437429810933.00.7001713566370.162162162Untagged9.00.206863679694947570.27205032550654728463.7396463186250.00484284554296395
Negative regulation of TCF-dependent signaling by WNT ligand antagonistspathwaypathway5.9551109552000.5735892965.955110955200.00.5735892962520.038461538Untagged8.00.214285714285714270.2673436041083150.00.00279015952582251
Phenylalanine and tyrosine catabolismpathwaypathway6.033998098270.7037037046.03399809827.00.70370370412060.004854369Untagged1.01.01.00.00.0027266529496015224
Role of phospholipids in phagocytosispathwaypathway6.06569697439300.7254079256.0656969743930.00.72540792525780.003460208Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
mRNA Splicing - Minor Pathwaypathwaypathway6.081626853530.6981132086.08162685353.00.698113208110149.86193E-4Untagged4.00.40.55555555555555560.50.002625139550160599
RIPK1-mediated regulated necrosispathwaypathway6.1102559092630.6642192856.110255909263.00.66421928521670.011976048Untagged11.00.141368078175895780.169578104946768840.50.0019036038780019609
TNFR1-induced NFkappaB signaling pathwaypathwaypathway6.1102559092630.6642192856.110255909263.00.66421928522900.006896552Untagged11.00.141368078175895780.169578104946768840.50.0019036038780019609
Regulation of TNFR1 signalingpathwaypathway6.1102559092630.6642192856.110255909263.00.66421928523250.006153846Untagged11.00.141368078175895780.169578104946768840.50.0019036038780019609
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwaypathwaypathway6.1102559092630.6642192856.110255909263.00.66421928521570.012738854Untagged11.00.141368078175895780.169578104946768840.50.0019036038780019609
Regulation of necroptotic cell deathpathwaypathway6.1102559092630.6642192856.110255909263.00.6642192852660.03030303Untagged11.00.141368078175895780.169578104946768840.50.0019036038780019609
Amine ligand-binding receptorspathwaypathway6.1240.56.124.00.51400.025Untagged4.00.357142857142857150.46666666666666670.00.0017968114881994888
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)pathwaypathway6.1338615523510.7108091736.133861552351.00.710809173717500.004Untagged10.00.180984153461217680.23871516348474931315.2494190020520.004723554427030849
Interleukin-4 and 13 signalingpathwaypathway6.163846248279500.7665089546.16384624827950.00.76650895492580.034883721Untagged8.00.249138920780711810.339817862628922312915.3012115077820.007722897526414495
Urea cyclepathwaypathway6.1688456631130.9218756.168845663113.00.92187521490.013422819Untagged1.01.01.01.00.003978809110339699
Platelet degranulation pathwaypathway6.231365403615690.7701191146.23136540361569.00.770119114722750.003076923Untagged10.00.181894383906119030.244629141979372941080.8794531491910.005378518520226369
Post-translational protein phosphorylationpathwaypathway6.2322430122700.67614556.232243012270.00.6761455515890.003146633Untagged10.00.180382377389858680.2344908931314467885.24941900205010.003685710892281156
Negative regulation of MAPK pathwaypathwaypathway6.263333333150.756.26333333315.00.7534940.006072874Untagged5.00.404761904761904770.4601307189542483650.00.0025673186508980866
Interleukin-1 family signalingpathwaypathway6.282459795422240.9729853486.28245979542224.00.972985348811080.007220217Untagged8.00.21047526673132880.248107307439104954779.4008491508470.00598161224350624
Regulation of TP53 Activity through Phosphorylationpathwaypathway6.3152228212000.6166666676.315222821200.00.61666666739640.003112033Untagged11.00.15850986121256390.210180474927019271323.56730769230740.002414495144805186
Ub-specific processing proteasespathwaypathway6.347540025458320.9566088366.34754002545832.00.956608836927430.003281079Untagged9.00.1939231456657730.25845585546046415182.4502997002970.008487355747571564
HDMs demethylate histonespathwaypathway6.3531.06.353.01.022350.008510638Untagged1.01.01.00.00.0027266529496015224
Role of LAT2/NTAL/LAB on calcium mobilizationpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990714290.002331002Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
GAB1 signalosomepathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990711680.005952381Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Nephrin family interactionspathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990711800.005555556Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Interleukin-3, 5 and GM-CSF signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712210.004524887Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
DAP12 signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990713860.002590674Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
G beta:gamma signalling through PI3Kgammapathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990713190.003134796Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PIP3 activates AKT signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.656759907110969.12409E-4Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Rho GTPase cyclepathwaypathway6.352121212274560.6567599076.35212121227456.00.656759907122614.42282E-4Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI3K events in ERBB4 signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990711310.007633588Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI3K events in ERBB2 signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712430.004115226Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by FGFR1 in diseasepathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071350.028571429Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
G alpha (12/13) signalling eventspathwaypathway6.352121212274560.6567599076.35212121227456.00.656759907111228.91266E-4Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI-3K cascade:FGFR4pathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712580.003875969Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by FGFR3 fusions in cancerpathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071100.1Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
CD28 dependent PI3K/Akt signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712470.004048583Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by FGFR2 in diseasepathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071300.033333333Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Regulation of signaling by CBLpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712220.004504505Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI3K/AKT activationpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990711240.008064516Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI-3K cascade:FGFR2pathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990713280.00304878Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Interleukin-7 signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712660.003759398Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
RET signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990714460.002242152Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI3K Cascadepathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990715250.001904762Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
GPVI-mediated activation cascadepathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990715680.001760563Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI-3K cascade:FGFR1pathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712690.003717472Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Costimulation by the CD28 familypathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071710.014084507Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by FGFR4 in diseasepathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071110.090909091Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by cytosolic FGFR1 fusion mutantspathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071180.055555556Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Tie2 Signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712570.003891051Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Downstream signal transductionpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990713950.002531646Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Signaling by FGFR3 point mutants in cancerpathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071240.041666667Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Interleukin receptor SHC signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712650.003773585Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
PI-3K cascade:FGFR3pathwaypathway6.352121212274560.6567599076.35212121227456.00.65675990712500.004Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
MET activates PI3K/AKT signalingpathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071890.011235955Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Constitutive Signaling by Aberrant PI3K in Cancerpathwaypathway6.352121212274560.6567599076.35212121227456.00.6567599071740.013513514Untagged10.00.178307313064913740.237914197937239780.00.0014185996128081506
Regulation of APC/C activators between G1/S and early anaphasepathwaypathway6.375077591240.56.37507759124.00.513860.002590674Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Cyclin E associated events during G1/S transition pathwaypathway6.375077591240.56.37507759124.00.511850.005405405Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Processing of DNA double-strand break endspathwaypathway6.375077591240.56.37507759124.00.518240.001213592Untagged11.00.157132512671976840.20380566693930804430.00.002597281611620672
Cyclin A:Cdk2-associated events at S phase entrypathwaypathway6.375077591240.56.37507759124.00.512140.004672897Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Meiotic recombinationpathwaypathway6.375077591240.56.37507759124.00.51820.012195122Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
G2 Phasepathwaypathway6.375077591240.56.37507759124.00.51820.012195122Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Activation of ATR in response to replication stresspathwaypathway6.375077591240.56.37507759124.00.515420.001845018Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexespathwaypathway6.375077591240.56.37507759124.00.51520.019230769Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Regulation of TP53 Degradationpathwaypathway6.375077591240.56.37507759124.00.513870.002583979Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
p53-Dependent G1 DNA Damage Responsepathwaypathway6.375077591240.56.37507759124.00.51680.014705882Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
PTK6 Regulates Cell Cyclepathwaypathway6.375077591240.56.37507759124.00.51270.037037037Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexespathwaypathway6.375077591240.56.37507759124.00.5130.333333333Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
Activation of the pre-replicative complexpathwaypathway6.375077591240.56.37507759124.00.515890.001697793Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrestpathwaypathway6.375077591240.56.37507759124.00.51970.010309278Untagged11.00.156678700361010840.199581396586005460.00.0013592634274590906
RUNX3 Regulates Immune Response and Cell Migrationpathwaypathway6.3841.06.384.01.0190.111111111Untagged12.00.137777777777777780.163494889646963570.00.0013187812806704088
Interferon alpha/beta signalingpathwaypathway6.41230265272241.06.4123026527224.01.022910.006872852Untagged9.00.167826759474091260.18685721600468210.33333333333333330.0019248433729375496
Respiratory electron transportpathwaypathway6.4331.06.433.01.036780.004424779Untagged0.00.00.00.04.0899794244022864E-4
Gluconeogenesispathwaypathway6.49580.7857142866.4958.00.78571428626630.003016591Untagged1.01.01.00.00.0027266529496015224
p130Cas linkage to MAPK signaling for integrinspathwaypathway6.540422228350.7465909096.54042222835.00.74659090942760.014492754Untagged10.00.182199832073887490.24194096993636222543.19647297147340.0034201033369954037
GRB2:SOS provides linkage to MAPK signaling for Integrins pathwaypathway6.540422228350.7465909096.54042222835.00.74659090942930.013651877Untagged10.00.182199832073887490.24194096993636222543.19647297147340.0034201033369954037
Integrin alphaIIb beta3 signalingpathwaypathway6.540422228350.7465909096.54042222835.00.74659090943960.01010101Untagged10.00.182199832073887490.24194096993636222543.19647297147340.0034201033369954037
Platelet Adhesion to exposed collagenpathwaypathway6.666396304200.8787878796.66639630420.00.8787878792990.02020202Untagged10.00.18068276436303080.23069453587886823116.960671346197660.0019274821571843982
Transport of organic anionspathwaypathway6.67010820221.06.6701082022.01.011520.006578947Untagged1.01.01.03.00.005230965271077875
Potassium transport channelspathwaypathway6.6750850354540.5330396486.675085035454.00.5330396481590.016949153Untagged1.01.01.00.00.0027266529496015224
Releasepathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Uncoating of the Influenza Virionpathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Buddingpathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Entry of Influenza Virion into Host Cell via Endocytosispathwaypathway6.68444444490.5555555566.6844444449.00.5555555561110.090909091Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Influenza Life Cyclepathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Viral mRNA Translationpathwaypathway6.68444444490.5555555566.6844444449.00.55555555611010.00990099Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Packaging of Eight RNA Segmentspathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatuspathwaypathway6.68444444490.5555555566.6844444449.00.555555556130.333333333Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Assembly of Viral Components at the Budding Sitepathwaypathway6.68444444490.5555555566.6844444449.00.555555556170.142857143Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Fusion of the Influenza Virion to the Host Cell Endosomepathwaypathway6.68444444490.5555555566.6844444449.00.555555556190.111111111Untagged12.00.13370301910043130.163540606858579320.00.0014870077772062198
Cell surface interactions at the vascular wallpathwaypathway6.691659626240.8756.69165962624.00.87549780.00408998Untagged10.00.185628742514970050.2458580206276064492.512652844232150.0036700898176740444
Pyrimidine biosynthesispathwaypathway6.70251648561.06.7025164856.01.01670.014925373Untagged1.01.01.00.00.0027266529496015224
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellpathwaypathway6.848148148170.8518518526.84814814817.00.85185185239510.003154574Untagged10.00.17919075144508670.234381171823568632357.203030303030.0031794339910998235
Synthesis of PCpathwaypathway6.886666667220.8333333336.88666666722.00.83333333324480.004464286Untagged13.00.121568627450980390.148070784821936780.00.001464229659786324
VEGF ligand-receptor interactionspathwaypathway6.957936508630.8253968256.95793650863.00.8253968251620.016129032Untagged2.00.66666666666666660.750.00.0021005748692324343
VEGF binds to VEGFR leading to receptor dimerizationpathwaypathway6.957936508630.8253968256.95793650863.00.8253968251990.01010101Untagged2.00.66666666666666660.750.00.0021005748692324343
Chylomicron clearancepathwaypathway6.9874946653580.5586592186.987494665358.00.5586592181610.016393443Untagged5.00.28571428571428570.37291666666666670.00.0017472045995132648
Metabolism of folate and pterinespathwaypathway7.043260274880.5922131157.04326027488.00.59221311513130.003194888Untagged9.00.177142857142857130.192941262526516750.00.0013062955423351714
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3pathwaypathway7.050651763790.5949367097.05065176379.00.59493670911500.006666667Untagged12.00.133210558624923260.154398993223878120.00.0014468414771899216
HIV elongation arrest and recoverypathwaypathway7.12735333120.6666666677.1273533312.00.6666666671360.027777778Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Formation of HIV-1 elongation complex containing HIV-1 Tatpathwaypathway7.12735333120.6666666677.1273533312.00.6666666671470.021276596Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Tat-mediated elongation of the HIV-1 transcriptpathwaypathway7.12735333120.6666666677.1273533312.00.6666666671450.022222222Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
RNA Polymerase II Transcription Elongationpathwaypathway7.12735333120.6666666677.1273533312.00.66666666717880.001269036Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Formation of RNA Pol II elongation complex pathwaypathway7.12735333120.6666666677.1273533312.00.66666666716140.001628664Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
TP53 Regulates Transcription of DNA Repair Genespathwaypathway7.12735333120.6666666677.1273533312.00.66666666719020.001108647Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Tat-mediated HIV elongation arrest and recoverypathwaypathway7.12735333120.6666666677.1273533312.00.6666666671350.028571429Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Formation of HIV elongation complex in the absence of HIV Tatpathwaypathway7.12735333120.6666666677.1273533312.00.6666666671480.020833333Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Pausing and recovery of Tat-mediated HIV elongationpathwaypathway7.12735333120.6666666677.1273533312.00.6666666671350.028571429Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Interactions of Tat with host cellular proteinspathwaypathway7.12735333120.6666666677.1273533312.00.666666667130.333333333Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Pausing and recovery of HIV elongationpathwaypathway7.12735333120.6666666677.1273533312.00.6666666671360.027777778Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
RNA Polymerase II Pre-transcription Eventspathwaypathway7.12735333120.6666666677.1273533312.00.666666667114476.91085E-4Untagged2.00.52173913043478260.54166666666666660.00.0015788431355915264
Assembly of active LPL and LIPC lipase complexespathwaypathway7.1342124494010.5932830977.134212449401.00.5932830972920.02173913Untagged3.00.50.583333333333333412.00.002951877764504914
Signaling by NODALpathwaypathway7.280930233430.6279069777.28093023343.00.62790697711200.008333333Untagged4.00.40.468750000000000060.00.001613671107431878
NGF processingpathwaypathway7.280930233430.6279069777.28093023343.00.6279069771640.015625Untagged4.00.40.468750000000000060.00.001613671107431878
Platelet sensitization by LDLpathwaypathway7.2919621021630.87.291962102163.00.821330.015037594Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Basigin interactionspathwaypathway7.3187514421.07.318751442.01.023620.005524862Untagged10.00.17570850202429150.21863616414307713216.00.0024099723126113108
ECM proteoglycanspathwaypathway7.366619105120.9583333337.36661910512.00.95833333345750.006956522Untagged10.00.185628742514970050.2439378977397416264.227933470038860.0026283780655050764
PECAM1 interactionspathwaypathway7.4741.07.474.01.01120.083333333Untagged12.00.139370584457289670.172250650015627340.00.0011311708437438885
Cross-presentation of particulate exogenous antigens (phagosomes)pathwaypathway7.4741.07.474.01.011290.007751938Untagged12.00.139370584457289670.172250650015627340.00.0011311708437438885
Elastic fibre formationpathwaypathway7.47333333381.07.4733333338.01.021940.010309278Untagged10.00.18068276436303080.23069453587886823104.830432140958410.001913813719407312
Laminin interactionspathwaypathway7.477581.07.47758.01.023640.005494505Untagged10.00.18068276436303080.23069453587886823104.830432140958410.001913813719407312
MET interacts with TNS proteinspathwaypathway7.4841.07.484.01.01730.01369863Untagged10.00.175424413904607920.215563967522493430.00.0011916408181036522
Smooth Muscle Contractionpathwaypathway7.4841.07.484.01.015490.001821494Untagged10.00.175424413904607920.215563967522493430.00.0011916408181036522
Localization of the PINCH-ILK-PARVIN complex to focal adhesionspathwaypathway7.4841.07.484.01.01380.026315789Untagged10.00.175424413904607920.215563967522493430.00.0011916408181036522
CHL1 interactionspathwaypathway7.4841.07.484.01.01160.0625Untagged10.00.175424413904607920.215563967522493430.00.0011916408181036522
Other semaphorin interactionspathwaypathway7.4841.07.484.01.011560.006410256Untagged10.00.175424413904607920.215563967522493430.00.0011916408181036522
Disassembly of the destruction complex and recruitment of AXIN to the membranepathwaypathway7.640014411120.7777777787.64001441112.00.77777777822240.008928571Untagged6.00.32278481012658230.3781045751633987410.00.0025088890754428423
Fibronectin matrix formationpathwaypathway7.6712580.8757.671258.00.87521290.015503876Untagged10.00.184680851063829780.238561553653720194.370228601807570.0019062051642014166
MET activates PTK2 signalingpathwaypathway7.6712580.8757.671258.00.87523910.00511509Untagged10.00.184680851063829780.238561553653720194.370228601807570.0019062051642014166
Cyclin D associated events in G1pathwaypathway7.8321.07.832.01.025190.003853565Untagged0.00.00.00.04.0899794244022864E-4
Non-integrin membrane-ECM interactionspathwaypathway7.862540.757.86254.00.7512940.003401361Untagged10.00.177723177723177720.21889949528198440.00.001123562288537993
Extracellular matrix organizationpathwaypathway7.862540.757.86254.00.7511780.005617978Untagged10.00.177723177723177720.21889949528198440.00.001123562288537993
Receptor Mediated Mitophagypathwaypathway8.0160.758.016.00.7511290.007751938Untagged13.00.121568627450980390.148070784821936780.00.001464229659786324
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownpathwaypathway8.0160.758.016.00.7515050.001980198Untagged13.00.12712360867018160.16349211464418859120.346153846153810.002426652085912232
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingpathwaypathway8.0160.758.016.00.7514240.002358491Untagged13.00.121568627450980390.148070784821936780.00.001464229659786324
Condensation of Prometaphase Chromosomespathwaypathway8.0160.758.016.00.7511570.006369427Untagged13.00.121568627450980390.148070784821936780.00.001464229659786324
WNT mediated activation of DVLpathwaypathway8.0160.758.016.00.7511130.008849558Untagged13.00.121568627450980390.148070784821936780.00.001464229659786324
Cytosolic tRNA aminoacylationpathwaypathway8.23521.08.2352.01.01470.021276596Untagged2.00.66666666666666660.750.00.0021005748692324343
SeMet incorporation into proteinspathwaypathway8.23521.08.2352.01.01110.090909091Untagged2.00.66666666666666660.750.00.0021005748692324343
G alpha (s) signalling eventspathwaypathway8.57666666770.8333333338.5766666677.00.833333333314410.002081888Untagged2.00.6250.76.00.003127038360082922
BBSome-mediated cargo-targeting to ciliumpathwaypathway8.66251.08.6625.01.011470.006802721Untagged1.01.01.00.00.0027266529496015224
NGF-independant TRKA activationpathwaypathway9.7621.09.762.01.01150.066666667Untagged4.00.41666666666666670.51666666666666660.00.0017392248143236618
Glucagon-type ligand receptorspathwaypathway9.80531.09.8053.01.022820.007092199Untagged4.00.41666666666666670.51666666666666660.00.0017392248143236618
CTLA4 inhibitory signalingpathwaypathway10.0133333331.010.013333333.01.012210.004524887Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
S37 mutants of beta-catenin aren't phosphorylatedpathwaypathway10.0133333331.010.013333333.01.01150.066666667Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalpathwaypathway10.0133333331.010.013333333.01.0111198.93655E-4Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Beta-catenin phosphorylation cascadepathwaypathway10.0133333331.010.013333333.01.012010.004975124Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
APC truncation mutants have impaired AXIN bindingpathwaypathway10.0133333331.010.013333333.01.01140.071428571Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
S33 mutants of beta-catenin aren't phosphorylatedpathwaypathway10.0133333331.010.013333333.01.01150.066666667Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
T41 mutants of beta-catenin aren't phosphorylatedpathwaypathway10.0133333331.010.013333333.01.01150.066666667Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
S45 mutants of beta-catenin aren't phosphorylatedpathwaypathway10.0133333331.010.013333333.01.01150.066666667Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
AXIN missense mutants destabilize the destruction complexpathwaypathway10.0133333331.010.013333333.01.01140.071428571Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Misspliced GSK3beta mutants stabilize beta-cateninpathwaypathway10.0133333331.010.013333333.01.01150.066666667Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
RAF activationpathwaypathway10.0133333331.010.013333333.01.013560.002808989Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Truncations of AMER1 destabilize the destruction complexpathwaypathway10.0133333331.010.013333333.01.01140.071428571Untagged6.00.286516853932584250.33006535947712420.00.0014833944188588312
Vacuolar protein sorting-associated protein 35targetunclassified5.020.5Predictionprediction9.00.178321678321678330.213826641767818150.00.0014777365348097333
Uroporphyrinogen-III synthasetargetenzyme5.0110.909090909Predictionprediction1.01.01.00.00.0027266529496015224
V-type proton ATPase subunit B- brain isoformtargetenzyme hydrolase, transporter ntpase f-type and v-type v-type atpase5.021.0Predictionprediction1.01.01.06.00.006483121431816054
Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteinstargetauxiliary transport protein fabp, enzyme5.0360.777777778Predictionprediction10.00.16426949280847840.21443018067442035958.50.007162323676749802
Kallikrein 8targetenzyme protease serine pas s1a5.021.0Predictionprediction5.00.347826086956521730.431249999999999970.00.0016710128302331003
Thioredoxin reductase 2targetenzyme5.021.0Predictionprediction13.00.118514472965592570.137322661977039740.00.001532687313842023
Splicing factor 3B subunit 2targetunclassified5.040.5Predictionprediction3.00.50.6111111111111112.00.0026068334618222105
Toll-like receptor 4/MD-2targetmembrane receptor, surface antigen5.01201.0Predictionprediction0.00.00.00.04.0899794244022864E-4
Toll-like receptor 4/MD-2/CD14targetmembrane receptor, surface antigen5.091.0Predictionprediction1.01.01.03.00.005230965271077875
Heme oxygenase 1targetenzyme5.031.0Actualprediction9.00.200369344413665750.2476373345036941431.00.0037120795769695313
Cofilin-1targetunclassified5.040.5Actualprediction11.00.154448398576512460.19318264940384727431.00.003599172380765105
Mitogen-activated protein kinase; ERK1/ERK2targetenzyme kinase protein kinase cmgc mapk erk5.080.5Actualprediction6.00.404761904761904770.625816993464052947.00.03057819450009074
ORAI 1/2/3targetion channel other misc crac-c5.0076190485670.761904762Predictionprediction11.00.152067274001401550.18934788969351155216.00.0029664986849140713
Histone deacetylasetargetenzyme, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv5.025864087103640.591084523Actualprediction10.00.182813816343723680.276444663887061355018.7454999678980.01333964209376289
von Willebrand factortargetunclassified5.039188911220.636363636Predictionprediction11.00.171813143309580360.2436983395508743688.92714931267570.006055333579376479
Integrin alpha Mtargetmembrane receptor5.044138505120.75Predictionprediction9.00.200740055504162820.2463316509399459126.158333333333430.0020083093729401863
Heat shock factor protein 1targetunclassified5.055052677300.6Actualprediction0.00.00.00.04.0899794244022864E-4
Interleukin-1 betatargetsecreted5.10714285770.714285714Predictionprediction9.00.2189707366296670.2709238534123335211.2323509823470.005291491197525053
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type IItargetenzyme reductase5.1130.666666667Predictionprediction1.01.01.03.00.005230965271077875
Protein disulfide-isomerasetargetenzyme5.1641638290.777777778Actualprediction11.00.154889364739471820.204012142491405041280.750.007678218117811655
Purinergic receptor P2Y12targetmembrane receptor 7tm1 smallmol nucleotide-like receptor purine receptor5.220.5Actualprediction0.00.00.00.04.0899794244022864E-4
Protein Wnt-3atargetunclassified5.2666954990.555555556Actualprediction7.00.268421052631578950.3593370681605978405.00.007234946911463422
Galectin-1targetcytosolic other5.268614844370.648648649Predictionprediction11.00.153573956121726830.18749908565576730.750.0019942089552043747
Hypoxanthine-guanine phosphoribosyltransferasetargetenzyme5.32070949550.6Actualprediction1.01.01.00.00.0027266529496015224
Histone-lysine N-methyltransferase NSD2targetepigenetic regulator writer pmt set5.348926307240.5Actualprediction12.00.13605015673981190.16602396579355086216.00.002911846263284332
Ribonucleoside-diphosphate reductase M2 chaintargetenzyme5.37516409760.666666667Actualprediction10.00.171813143309580360.20670580059980978216.00.0022577474847268555
Serum amyloid P-componenttargetsecreted5.41464563721.0Predictionprediction1.01.01.00.00.0027266529496015224
Solute carrier organic anion transporter family member 4A1targettransporter electrochemical slc slc215.43628561120.5Predictionprediction2.00.60.66666666666666660.00.0018918821757760705
Tubulin beta-1 chaintargetstructural5.44857142970.857142857Actualprediction0.00.00.00.04.0899794244022864E-4
Tubulintargetstructural5.456414547614090.883502418Actualprediction11.00.15400993612491130.187038256162679770.00.0011704275229214062
Heterogeneous nuclear ribonucleoprotein A1targetunclassified5.5241.0Actualprediction3.00.60.72222222222222239.00.004218448085898324
Prolactin receptortargetunclassified5.6121.0Predictionprediction8.00.23181818181818180.286227824463118350.00.0030350802141954287
Proteasome Macropain subunittargetenzyme protease threonine pbt t1a5.65333333331.0Actualprediction8.00.200740055504162820.22796247531270572661.21363358863370.0018559588557341767
Histone deacetylase (HDAC1 and HDAC2)targetepigenetic regulator eraser hdac hdac class i5.741.0Actualprediction10.00.17919075144508670.247796430400117651077.59523809523720.007466916810915321
Sphingosine 1-phosphate receptor Edg-5targetmembrane receptor 7tm1 smallmol lipid-like ligand receptor edg receptor5.7421.0Actualprediction1.01.01.00.00.0027266529496015224
Histone deacetylase 3targetepigenetic regulator eraser hdac hdac class i5.741160217160.75Actualprediction12.00.137952956134774320.1871288593638822422.72222222222220.004628750135250316
Proline-rich AKT1 substrate 1targetunclassified5.7540.5Predictionprediction0.00.00.00.04.0899794244022864E-4
G-protein coupled receptor 55targetmembrane receptor 7tm1 smallmol lipid-like ligand receptor lysophosphatidylinositol receptor5.78333333330.666666667Actualprediction4.00.40.52083333333333330.00.0018342001576266544
Ras-related protein Rap-1Atargetunclassified5.7950.6Predictionprediction11.00.155778894472361820.208082803013678541070.750.00788704757135434
CREB-binding proteintargetepigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp5.81875160.625Actualprediction12.00.140817650876054520.232443759517493333141.7744939271250.019790234611574017
Small conductance calcium-activated potassium channel protein 3targetion channel vgc k ca act k5.83666666760.666666667Actualprediction1.01.01.00.00.0027266529496015224
Orexin receptor 1targetmembrane receptor 7tm1 peptide short peptide orexin receptor5.84521.0Actualprediction4.00.40.52083333333333330.00.0018342001576266544
Galanin receptor 3targetmembrane receptor 7tm1 peptide short peptide galanin receptor5.88470139260.5Actualprediction0.00.00.00.04.0899794244022864E-4
Chymasetargetenzyme protease serine pas s1a5.89291786730.666666667Actualprediction1.01.01.01.00.003978809110339699
Heat shock protein HSP 90-alphatargetcytosolic other5.933361395800.5625Actualprediction7.00.235613463626492940.293438665788896777818.9863303363630.01347885915407883
Cannabinoid CB1 receptor/orexin receptor 1 complextargetmembrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor5.933538486720.722222222Predictionprediction2.00.66666666666666660.754.00.00325940237281308
Muscarinic acetylcholine receptor M1/M5 chimeric proteintargetmembrane receptor 7tm1 smallmol monoamine receptor acetylcholine receptor5.9378755991040.5Predictionprediction1.01.01.00.00.0027266529496015224
Nuclear receptor coactivator 3targetepigenetic regulator writer hat src5.976518006110.636363636Actualprediction12.00.137081490840176870.17176787626096360.00.0011403613828064518
E3 SUMO-protein ligase CBX4targetenzyme5.98520.5Predictionprediction12.00.136735979836168860.17047316482800323160.278846153846130.0022633112756610795
Corticotropin-releasing factor-binding proteintargetunclassified6.060.5Predictionprediction9.00.178321678321678330.213826641767818150.00.0014777365348097333
Tyrosine aminotransferasetargetenzyme6.033998098270.703703704Predictionprediction1.01.01.00.00.0027266529496015224
Splicing factor 3B subunit 3targetunclassified6.081626853530.698113208Predictionprediction3.00.50.6111111111111112.00.0026068334618222105
Proto-oncogene protein Wnt-3targetunclassified6.0884641391420.514084507Predictionprediction9.00.180851063829787250.231800497976968442.00.002546475127179238
Tubulin beta-2 chaintargetstructural6.09539921521.0Actualprediction0.00.00.00.04.0899794244022864E-4
Trace amine-associated receptor 1targetmembrane receptor 7tm1 smallmol monoamine receptor trace amine receptor6.1240.5Actualprediction3.00.50.63333333333333344.00.0032643461240343123
Arginase-1targetenzyme6.126875640.84375Predictionprediction2.00.66666666666666660.750.00.0021005748692324343
Solute carrier organic anion transporter family member 1C1targettransporter electrochemical slc slc21, unclassified6.13960677960.5Predictionprediction2.00.60.66666666666666660.00.0018918821757760705
Histone deacetylase 1targetenzyme, epigenetic regulator eraser hdac hdac class i6.143091837470.85106383Actualprediction10.00.17919075144508670.247796430400117651077.59523809523720.007466916810915321
Arginase-2- mitochondrialtargetenzyme6.210816327491.0Predictionprediction2.00.66666666666666660.750.00.0021005748692324343
26S proteosometargetenzyme, enzyme protease threonine pbt t1a, unclassified6.25172201.0Actualprediction8.00.201112140871177010.2310346719332895768.71363358863380.00267362323680688
COUP transcription factor 2targettranscription factor nuclear receptor nr2 nr2f nr2f26.28995203860.833333333Actualprediction0.00.00.00.04.0899794244022864E-4
PI3-kinase class Itargetenzyme, unclassified6.352121212274560.656759907Predictionprediction9.00.216783216783216770.364841635578963157793.662246087240.04747733483826884
CDK2/Cyclin A1targetcytosolic other, enzyme kinase protein kinase cmgc cdk cdc26.375077591240.5Predictionprediction10.00.185628742514970050.27953880476921995955.8914835164860.0201132453842807
Leukocyte adhesion glycoprotein LFA-1 alphatargetadhesion, membrane receptor6.3841.0Actualprediction11.00.159676232523914640.20280520810474711276.436363636363750.0032089709739432084
Proteasome component C5targetenzyme protease threonine pbt t1a6.3931.0Actualprediction8.00.200740055504162820.22796247531270572661.21363358863370.0018559588557341767
Proteasome subunit beta type-8targetenzyme protease threonine pbt t1a6.57360530341.0Actualprediction8.00.201112140871177010.2310346719332895768.71363358863380.00267362323680688
Lysine-specific demethylase 5Atargetepigenetic regulator eraser kdm jumonji, epigenetic regulator reader phd6.621.0Actualprediction1.01.01.00.00.0027266529496015224
Secreted frizzled-related protein 1targetunclassified6.6435264211910.591623037Predictionprediction9.00.177083333333333340.208924680983504450.00.0015942871678883384
Solute carrier organic anion transporter family member 4C1targettransporter electrochemical slc slc216.67010820221.0Actualprediction2.00.60.66666666666666660.00.0018918821757760705
ATP-sensitive inward rectifier potassium channel 1targetion channel vgc k kir, unclassified6.6750850354540.533039648Predictionprediction1.01.01.00.00.0027266529496015224
Hemagglutinintargetunclassified6.68444444490.555555556Predictionprediction11.00.154228855721393030.2132451905493382115.00.013942300462282198
Dihydroorotate dehydrogenasetargetenzyme, enzyme reductase6.70251648561.0Actualprediction1.01.01.00.00.0027266529496015224
Prostasintargetenzyme protease serine pas s1a6.707826087230.608695652Predictionprediction5.00.347826086956521730.431249999999999970.00.0016710128302331003
Non-secretory ribonucleasetargetenzyme6.7420.5Predictionprediction0.00.00.00.04.0899794244022864E-4
Glucose-6-phosphate translocasetargettransporter electrochemical slc slc376.7570.571428571Predictionprediction1.01.01.00.00.0027266529496015224
Sodium/potassium-transporting ATPase alpha-1 chaintargetenzyme hydrolase, transporter ntpase p-type atpase na k atpase6.961.0Actualprediction0.00.00.00.04.0899794244022864E-4
Placenta growth factortargetunclassified6.957936508630.825396825Predictionprediction1.01.01.01.00.003978809110339699
Hepatic lipasetargetenzyme6.9874946653580.558659218Predictionprediction4.00.380952380952380930.57.00.003148377893225996
Dihydrofolate reductasetargetenzyme, enzyme reductase, unclassified7.043260274880.592213115Actualprediction8.00.215064420218037650.244201228878648456621.9324841825080.003164981939637638
Prostate specific antigentargetenzyme protease serine pas s1a7.050651763790.594936709Predictionprediction11.00.153573956121726830.1874990856557673216.00.002440823649304329
Potassium-transporting ATPase alpha chain 2targetenzyme hydrolase, transporter ntpase p-type atpase h k atpase7.121.0Actualprediction0.00.00.00.04.0899794244022864E-4
CDK9/Cyclin Ktargetenzyme kinase protein kinase cmgc cdk cdk9, unclassified7.12735333120.666666667Predictionprediction1.01.01.066.00.016500370717721466
Baculoviral IAP repeat-containing protein 3targetenzyme7.2205118172270.550660793Predictionprediction10.00.163773584905660380.2082857874332528527.50.005173433667284805
Sodium/potassium-transporting ATPasetargetenzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase7.2659601.0Actualprediction11.00.149552033080634060.17461231804549740.00.001432686450426878
Subtilisin/kexin type 6targetenzyme protease serine sb s8b7.280930233430.627906977Predictionprediction3.00.61538461538461540.729166666666666622.00.005668364405452068
Tankyrase 1/2targetenzyme7.4280.5Predictionprediction10.00.162546816479400750.192924804330333880.00.0011300293879135217
Integrin alpha-V/beta-3targetmembrane receptor7.4741.0Actualprediction11.00.161819537658463820.22469460902640617600.80962254120130.007640881956802024
Integrin alpha1/beta1 complextargetmembrane receptor7.4841.0Predictionprediction9.00.212536728697355540.298866213151927354898.2047341547340.013801601308931261
Proteasome subunit beta type-7targetunclassified7.69897000481.0Predictionprediction8.00.200740055504162820.22796247531270572661.21363358863370.0018559588557341767
Proteasome Macropain subunit MB1targetenzyme protease threonine pbt t1a7.703082613111.0Actualprediction8.00.200740055504162820.22796247531270572661.21363358863370.0018559588557341767
Proteinase-activated receptor 2targetmembrane receptor 7tm1 peptide protease-activated receptor, membrane receptor 7tm1 peptide protease-activated receptor protease-activated receptor7.74541.0Actualprediction0.00.00.00.04.0899794244022864E-4
Fibronectintargetadhesion7.862540.75Predictionprediction9.00.215920398009950250.303781727744861736049.016436049330.011760497212861456
Casein kinase II alpha/betatargetenzyme kinase protein kinase other ck2, enzyme kinase reg8.0160.75Predictionprediction12.00.13830465264499680.186607683151461731234.56730769230740.008685825705168286
Kininogen-1targetunclassified8.0662903231240.620967742Predictionprediction11.00.156678700361010840.2007095311242774246.931818181818190.0027556385356855523
Tubulin beta-3 chaintargetstructural8.167541.0Actualprediction0.00.00.00.04.0899794244022864E-4
Arginyl-tRNA synthetasetargetenzyme8.23521.0Predictionprediction1.01.01.01.00.003978809110339699
Opioid receptors; delta & kappatargetmembrane receptor 7tm1 peptide short peptide opioid receptor8.2635661371760.522727273Predictionprediction9.00.199632014719411220.241492941262526570.00.0012289727076142327
Somatostatin receptortargetmembrane receptor 7tm1 peptide short peptide somatostatin receptor8.66251.0Actualprediction1.01.01.00.00.0027266529496015224
Pituitary adenylate cyclase-activating polypeptidetargetunclassified9.7621.0Predictionprediction3.00.6250.76666666666666667.00.004693272096645086
Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoformtargetenzyme phosphatase protein phosphatase reg10.0133333331.0Predictionprediction5.00.39843750.5251633986928104869.00.018946388392949917
Best protein/pathway scores with centrality measures