BrCa graph data table

BrCa selection table with centrality measures

name	typeofnode	targetclass	avgchemblscoretarget	countchemblscoretarget	countratiotarget	brcaactivities	avgchemblscorepathway	countchemblscorepathway	countratiopathway	numberofpathwayproteinswithrecords	totalnumberofproteinsinthepathway	rateproteinswithrecordsvstotalpathwayproteins	targetidentifiedfrom	eccentricity	closnesscentrality	harmonicclosnesscentrality	betweenesscentrality	pageranks
Signal attenuation	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	115	0.008695652	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
EPHB-mediated forward signaling	pathway	pathway	5.0	4	0.5		5.0	4.0	0.5	1	602	0.00166113	Untagged	12.0	0.1338679827267119	0.1570542488745255	0.0	0.0014292794771940834
RHO GTPases Activate WASPs and WAVEs	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	547	0.001828154	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Transferrin endocytosis and recycling	pathway	pathway	5.0	2	1.0		5.0	2.0	1.0	1	478	0.00209205	Untagged	2.0	0.5714285714285714	0.625	0.0	0.0017875358290478892
Golgi Cisternae Pericentriolar Stack Reorganization	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	125	0.008	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Negative regulation of FGFR3 signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	281	0.003558719	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
ISG15 antiviral mechanism	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	334	0.002994012	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Gastrin-CREB signalling pathway via PKC and MAPK	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	146	0.006849315	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Ion channel transport	pathway	pathway	5.0	2	1.0		5.0	2.0	1.0	1	286	0.003496503	Untagged	2.0	0.5714285714285714	0.625	0.0	0.0017875358290478892
CREB phosphorylation through the activation of Ras	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	256	0.00390625	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
phospho-PLA2 pathway	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	29	0.034482759	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
ROS, RNS production in phagocytes	pathway	pathway	5.0	2	1.0		5.0	2.0	1.0	1	518	0.001930502	Untagged	2.0	0.5714285714285714	0.625	0.0	0.0017875358290478892
Spry regulation of FGF signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	187	0.005347594	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Heme degradation	pathway	pathway	5.0	3	1.0		5.0	3.0	1.0	1	89	0.011235955	Untagged	10.0	0.16705157813702848	0.19329054202326157	0.0	0.0014613369130400443
Toll Like Receptor TLR1:TLR2 Cascade	pathway	pathway	5.0	9	1.0		5.0	9.0	1.0	1	7	0.142857143	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
MAPK3 (ERK1) activation	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	141	0.007092199	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Toll Like Receptor TLR6:TLR2 Cascade	pathway	pathway	5.0	9	1.0		5.0	9.0	1.0	1	4	0.25	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Iron uptake and transport	pathway	pathway	5.0	3	1.0		5.0	3.0	1.0	1	469	0.002132196	Untagged	10.0	0.16705157813702848	0.19329054202326157	0.0	0.0014613369130400443
Negative regulation of FGFR1 signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	322	0.00310559	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Insulin receptor recycling	pathway	pathway	5.0	2	1.0		5.0	2.0	1.0	1	422	0.002369668	Untagged	2.0	0.5714285714285714	0.625	0.0	0.0017875358290478892
Negative feedback regulation of MAPK pathway	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	157	0.006369427	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
MAPK1 (ERK2) activation	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	136	0.007352941	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Apoptotic cleavage of cellular proteins	pathway	pathway	5.0	36	0.777777778		5.0	36.0	0.777777778	1	271	0.003690037	Untagged	11.0	0.14118412491867274	0.16650590832618514	0.0	0.0011703467400629608
ERKs are inactivated	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	222	0.004504505	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
NCAM signaling for neurite out-growth	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	364	0.002747253	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Heme biosynthesis	pathway	pathway	5.0	11	0.909090909		5.0	11.0	0.909090909	1	214	0.004672897	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
RNA Polymerase I Promoter Opening	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	84	0.011904762	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
RSK activation	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	134	0.007462687	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	pathway	pathway	5.0	4	0.5		5.0	4.0	0.5	1	38	0.026315789	Untagged	12.0	0.1338679827267119	0.1570542488745255	0.0	0.0014292794771940834
Negative regulation of FGFR4 signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	296	0.003378378	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Advanced glycosylation endproduct receptor signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	74	0.013513514	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Negative regulation of FGFR2 signaling	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	359	0.002785515	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Transfer of LPS from LBP carrier to CD14	pathway	pathway	5.0	9	1.0		5.0	9.0	1.0	1	18	0.055555556	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Thrombin signalling through proteinase activated receptors (PARs)	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	212	0.004716981	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Signaling by Retinoic Acid	pathway	pathway	5.0	36	0.777777778		5.0	36.0	0.777777778	1	320	0.003125	Untagged	11.0	0.14118412491867274	0.16650590832618514	0.0	0.0011703467400629608
FCERI mediated MAPK activation	pathway	pathway	5.0	8	0.5		5.0	8.0	0.5	1	677	0.001477105	Untagged	7.0	0.2897727272727273	0.3631652661064424	0.0	0.001492922174479484
Elevation of cytosolic Ca2+ levels	pathway	pathway	5.007619048	567	0.761904762		5.007619048	567.0	0.761904762	1	201	0.004975124	Untagged	12.0	0.1320754716981132	0.15522373172142778	0.0	0.0016704991731886604
SUMOylation of DNA damage response and repair proteins	pathway	pathway	5.025864087	10364	0.591084523		5.025864087	10364.0	0.591084523	1	892	0.001121076	Untagged	11.0	0.15645277577505406	0.2035039333426437	340.43269230769226	0.0019388519616099797
RUNX3 regulates p14-ARF	pathway	pathway	5.025864087	10364	0.591084523		5.025864087	10364.0	0.591084523	1	142	0.007042254	Untagged	11.0	0.15466856735566642	0.1967451007773595	0.0	9.764295354840718E-4
Platelet Aggregation (Plug Formation)	pathway	pathway	5.039188911	22	0.636363636		5.039188911	22.0	0.636363636	1	71	0.014084507	Untagged	12.0	0.14672075726842462	0.18560921924977286	0.0	0.0011448392815209746
Detoxification of Reactive Oxygen Species	pathway	pathway	5.08208191	11	0.888888889		5.08208191	11.0	0.888888889	2	571	0.003502627	Untagged	12.0	0.13436532507739937	0.1638459978321733	216.0	0.0026450886369640612
Interleukin-10 signaling	pathway	pathway	5.107142857	7	0.714285714		5.107142857	7.0	0.714285714	1	109	0.009174312	Untagged	10.0	0.17978458989229495	0.20661802355350806	0.0	0.0013090419171511401
FGFR2 alternative splicing	pathway	pathway	5.11	6	1.0		5.11	6.0	1.0	2	419	0.00477327	Untagged	4.0	0.4	0.4861111111111111	0.0	0.0016043914932623146
Processing of Capped Intron-Containing Pre-mRNA	pathway	pathway	5.11	6	1.0		5.11	6.0	1.0	2	475	0.004210526	Untagged	4.0	0.4	0.4861111111111111	0.0	0.0016043914932623146
Androgen biosynthesis	pathway	pathway	5.11	3	0.666666667		5.11	3.0	0.666666667	1	142	0.007042254	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Glucocorticoid biosynthesis	pathway	pathway	5.11	3	0.666666667		5.11	3.0	0.666666667	1	112	0.008928571	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Mineralocorticoid biosynthesis	pathway	pathway	5.11	3	0.666666667		5.11	3.0	0.666666667	1	71	0.014084507	Untagged	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Glycosphingolipid metabolism	pathway	pathway	5.145980003	3	1.0		5.145980003	3.0	1.0	3	628	0.00477707	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Purine salvage	pathway	pathway	5.151679919	12	0.585714286		5.151679919	12.0	0.585714286	2	243	0.008230453	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Interleukin-12 family signaling	pathway	pathway	5.16416382	9	0.777777778		5.16416382	9.0	0.777777778	1	230	0.004347826	Untagged	12.0	0.1341991341991342	0.1607738012115895	0.0	0.0013418349964516964
Collagen biosynthesis and modifying enzymes	pathway	pathway	5.16416382	9	0.777777778		5.16416382	9.0	0.777777778	1	807	0.001239157	Untagged	12.0	0.1341991341991342	0.1607738012115895	0.0	0.0013418349964516964
Chylomicron assembly	pathway	pathway	5.16416382	9	0.777777778		5.16416382	9.0	0.777777778	1	103	0.009708738	Untagged	12.0	0.1341991341991342	0.1607738012115895	0.0	0.0013418349964516964
VLDL assembly	pathway	pathway	5.16416382	9	0.777777778		5.16416382	9.0	0.777777778	1	50	0.02	Untagged	12.0	0.1341991341991342	0.1607738012115895	0.0	0.0013418349964516964
VEGFR2 mediated vascular permeability	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	342	0.005847953	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
Scavenging by Class F Receptors	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	11	0.181818182	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
EPHA-mediated growth cone collapse	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	382	0.005235602	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
Signaling by ERBB2	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	232	0.00862069	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
eNOS activation	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	118	0.016949153	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
Downregulation of ERBB2 signaling	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	327	0.006116208	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
vRNP Assembly	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	6	0.333333333	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
PIWI-interacting RNA (piRNA) biogenesis	pathway	pathway	5.182573762	288	0.752403846		5.182573762	288.0	0.752403846	2	58	0.034482759	Untagged	8.0	0.19085312225153914	0.21668312486284896	0.0	0.0013643942200226977
Chromatin modifying enzymes	pathway	pathway	5.183333333	5	1.0		5.183333333	5.0	1.0	3	107	0.028037383	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Growth hormone receptor signaling	pathway	pathway	5.203333333	12	0.666666667		5.203333333	12.0	0.666666667	2	176	0.011363636	Untagged	7.0	0.29651162790697677	0.3811391223155927	98.0	0.0027837910033156037
Metabolism of Angiotensinogen to Angiotensins	pathway	pathway	5.230479386	4	0.833333333		5.230479386	4.0	0.833333333	2	148	0.013513514	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
CLEC7A/inflammasome pathway	pathway	pathway	5.256432251	22	0.654761905		5.256432251	22.0	0.654761905	3	45	0.066666667	Untagged	10.0	0.17978458989229495	0.20661802355350806	0.0	0.0013090419171511401
RNF mutants show enhanced WNT signaling and proliferation	pathway	pathway	5.26669549	9	0.555555556		5.26669549	9.0	0.555555556	1	8	0.125	Untagged	8.0	0.2125	0.2542717086834734	0.0	0.0014344925990242398
Regulation of FZD by ubiquitination	pathway	pathway	5.26669549	9	0.555555556		5.26669549	9.0	0.555555556	1	175	0.005714286	Untagged	8.0	0.2125	0.2542717086834734	0.0	0.0014344925990242398
Interleukin-1 processing	pathway	pathway	5.27798171	19	0.648809524		5.27798171	19.0	0.648809524	2	69	0.028985507	Untagged	10.0	0.17978458989229495	0.20661802355350806	0.0	0.0013090419171511401
Activation of Matrix Metalloproteinases	pathway	pathway	5.309040953	5	0.833333333		5.309040953	5.0	0.833333333	2	401	0.004987531	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
Interconversion of nucleotide di- and triphosphates	pathway	pathway	5.375164097	6	0.666666667		5.375164097	6.0	0.666666667	1	569	0.001757469	Untagged	11.0	0.14672075726842462	0.16740562305078466	0.0	0.0013690441116493116
Association of TriC/CCT with target proteins during biosynthesis	pathway	pathway	5.383512152	10380	0.670542262		5.383512152	10380.0	0.670542262	2	205	0.009756098	Untagged	11.0	0.15488936473947182	0.1998172973979432	32.24912280701756	0.001632664400168809
NR1D1 (REV-ERBA) represses gene expression	pathway	pathway	5.383512152	10380	0.670542262		5.383512152	10380.0	0.670542262	2	6	0.333333333	Untagged	11.0	0.15488936473947182	0.1998172973979432	32.24912280701756	0.001632664400168809
Orexin and neuropeptides FF and QRFP bind to their respective receptors	pathway	pathway	5.392159498	76	0.907407407		5.392159498	76.0	0.907407407	3	58	0.051724138	Untagged	3.0	0.5714285714285714	0.7083333333333333	3.0	0.003352731029970611
Amyloid fiber formation	pathway	pathway	5.414645637	2	1.0		5.414645637	2.0	1.0	1	71	0.014084507	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
mRNA Splicing - Major Pathway	pathway	pathway	5.433875618	59	0.899371069		5.433875618	59.0	0.899371069	3	3115	9.63082E-4	Untagged	2.0	0.6666666666666666	0.75	9.5	0.003820533100982685
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	8	0.125	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
TRAF6 mediated NF-kB activation	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	208	0.004807692	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
PKMTs methylate histone lysines	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	390	0.002564103	Untagged	13.0	0.11982330204307012	0.1391284982298806	0.0	0.0016470161266018098
IkBA variant leads to EDA-ID	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	7	0.142857143	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	152	0.006578947	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Regulated proteolysis of p75NTR	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	98	0.010204082	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
NF-kB is activated and signals survival	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	135	0.007407407	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	352	0.002840909	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
RIP-mediated NFkB activation via ZBP1	pathway	pathway	5.448820563	12	0.583333333		5.448820563	12.0	0.583333333	1	190	0.005263158	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
HATs acetylate histones	pathway	pathway	5.459375	17	0.8125		5.459375	17.0	0.8125	2	588	0.003401361	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Transcription of E2F targets under negative control by DREAM complex	pathway	pathway	5.464829741	10516	0.811032138		5.464829741	10516.0	0.811032138	4	27	0.148148148	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
BMAL1:CLOCK,NPAS2 activates circadian gene expression	pathway	pathway	5.528591435	10396	0.655361508		5.528591435	10396.0	0.655361508	3	67	0.044776119	Untagged	11.0	0.1585098612125639	0.22017060000931024	486.91512113617443	0.0024742439129721715
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	pathway	pathway	5.528591435	10396	0.655361508		5.528591435	10396.0	0.655361508	3	253	0.011857708	Untagged	11.0	0.1585098612125639	0.22017060000931024	486.91512113617443	0.0024742439129721715
Transcriptional activation of mitochondrial biogenesis	pathway	pathway	5.528591435	10396	0.655361508		5.528591435	10396.0	0.655361508	3	219	0.01369863	Untagged	11.0	0.1585098612125639	0.22017060000931024	486.91512113617443	0.0024742439129721715
NoRC negatively regulates rRNA expression	pathway	pathway	5.573331376	13868	0.803784427		5.573331376	13868.0	0.803784427	4	176	0.022727273	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
RNA Polymerase I Transcription Initiation	pathway	pathway	5.573331376	13868	0.803784427		5.573331376	13868.0	0.803784427	4	537	0.00744879	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
Regulation of TP53 Activity through Acetylation	pathway	pathway	5.573331376	13868	0.803784427		5.573331376	13868.0	0.803784427	4	211	0.018957346	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	pathway	pathway	5.573331376	13868	0.803784427		5.573331376	13868.0	0.803784427	4	78	0.051282051	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
Prolactin receptor signaling	pathway	pathway	5.61	2	1.0		5.61	2.0	1.0	1	125	0.008	Untagged	9.0	0.18888888888888888	0.22213663243074996	0.0	0.0016998667712763483
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	pathway	pathway	5.622985308	10415	0.814049451		5.622985308	10415.0	0.814049451	3	27	0.111111111	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
Downregulation of SMAD2/3:SMAD4 transcriptional activity	pathway	pathway	5.622985308	10415	0.814049451		5.622985308	10415.0	0.814049451	3	374	0.00802139	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
Deactivation of the beta-catenin transactivating complex	pathway	pathway	5.622985308	10415	0.814049451		5.622985308	10415.0	0.814049451	3	452	0.006637168	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	pathway	pathway	5.622985308	10415	0.814049451		5.622985308	10415.0	0.814049451	3	438	0.006849315	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
Repression of WNT target genes	pathway	pathway	5.622985308	10415	0.814049451		5.622985308	10415.0	0.814049451	3	105	0.028571429	Untagged	11.0	0.15511079342387418	0.2028894940185269	2.1643049932523617	0.0020352362888410623
CD209 (DC-SIGN) signaling	pathway	pathway	5.633785282	28	0.604166667		5.633785282	28.0	0.604166667	2	290	0.006896552	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Activation of anterior HOX genes in hindbrain development during early embryogenesis	pathway	pathway	5.640573077	10407	0.65061204		5.640573077	10407.0	0.65061204	4	178	0.02247191	Untagged	11.0	0.15874177029992684	0.22324279662989396	702.9151211361743	0.0034440460960183097
Degradation of the extracellular matrix	pathway	pathway	5.64691601	6	0.9375		5.64691601	6.0	0.9375	3	883	0.003397508	Untagged	10.0	0.17772317772317772	0.21889949528198438	0.0	0.001123562288537993
Formation of the beta-catenin:TCF transactivating complex	pathway	pathway	5.671926481	10431	0.766787088		5.671926481	10431.0	0.766787088	4	413	0.00968523	Untagged	11.0	0.15874177029992684	0.22324279662989396	1320.8800687616424	0.002876815801644425
WNT ligand biogenesis and trafficking	pathway	pathway	5.677579815	151	0.534820031		5.677579815	151.0	0.534820031	2	312	0.006410256	Untagged	8.0	0.21610169491525424	0.2804154995331466	73.5	0.003773841243687631
Class B/2 (Secretin family receptors)	pathway	pathway	5.677579815	151	0.534820031		5.677579815	151.0	0.534820031	2	219	0.00913242	Untagged	8.0	0.21610169491525424	0.2804154995331466	73.5	0.0037738412436876313
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	pathway	pathway	5.67987013	28023	0.709332334		5.67987013	28023.0	0.709332334	2	433	0.004618938	Untagged	10.0	0.17889530090684255	0.24213846829054236	430.0	0.0026801008435565826
GP1b-IX-V activation signalling	pathway	pathway	5.695655062	27478	0.646561772		5.695655062	27478.0	0.646561772	2	161	0.01242236	Untagged	10.0	0.18468085106382978	0.2544272547728773	496.9396769896766	0.0021544409518888964
Lysosphingolipid and LPA receptors	pathway	pathway	5.74	2	1.0		5.74	2.0	1.0	1	104	0.009615385	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	pathway	pathway	5.767347487	41400	0.704581876		5.767347487	41400.0	0.704581876	3	19	0.157894737	Untagged	8.0	0.2060778727445394	0.26437897739741073	879.6577311577314	0.0023739958903906196
Constitutive Signaling by EGFRvIII	pathway	pathway	5.767347487	41400	0.704581876		5.767347487	41400.0	0.704581876	3	15	0.2	Untagged	8.0	0.2060778727445394	0.26437897739741073	879.6577311577314	0.0023739958903906196
Rap1 signalling	pathway	pathway	5.79	5	0.6		5.79	5.0	0.6	1	226	0.004424779	Untagged	12.0	0.1348663766314481	0.16273781262260553	0.0	0.0012475247505132334
MET activates RAP1 and RAC1	pathway	pathway	5.79	5	0.6		5.79	5.0	0.6	1	179	0.005586592	Untagged	12.0	0.1348663766314481	0.16273781262260553	0.0	0.0012475247505132334
ARMS-mediated activation	pathway	pathway	5.79	5	0.6		5.79	5.0	0.6	1	75	0.013333333	Untagged	12.0	0.1348663766314481	0.16273781262260553	0.0	0.0012475247505132334
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	pathway	pathway	5.79	5	0.6		5.79	5.0	0.6	1	415	0.002409639	Untagged	12.0	0.1348663766314481	0.16273781262260553	0.0	0.0012475247505132334
Frs2-mediated activation	pathway	pathway	5.79	5	0.6		5.79	5.0	0.6	1	100	0.01	Untagged	12.0	0.1348663766314481	0.16273781262260553	0.0	0.0012475247505132334
Formation of the cornified envelope	pathway	pathway	5.797751264	56	0.847320526		5.797751264	56.0	0.847320526	4	975	0.004102564	Untagged	4.0	0.5	0.6354166666666666	13.0	0.0044546840083874994
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	pathway	pathway	5.802802598	776	0.699006936		5.802802598	776.0	0.699006936	3	140	0.021428571	Untagged	7.0	0.223480947476828	0.24727891156462614	6573.718198468222	0.0022616918199176404
DNA Damage/Telomere Stress Induced Senescence	pathway	pathway	5.814496172	34	0.666666667		5.814496172	34.0	0.666666667	2	302	0.006622517	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Activation of gene expression by SREBF (SREBP)	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	49	0.020408163	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Activation of the TFAP2 (AP-2) family of transcription factors	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	123	0.008130081	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
TRAF3-dependent IRF activation pathway	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	71	0.014084507	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
YAP1- and WWTR1 (TAZ)-stimulated gene expression	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	129	0.007751938	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
RUNX3 regulates NOTCH signaling	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	162	0.00617284	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Pre-NOTCH Transcription and Translation	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	37	0.027027027	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	76	0.013157895	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	50	0.02	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
RUNX3 regulates YAP1-mediated transcription	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	88	0.011363636	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	118	0.008474576	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
TRAF6 mediated IRF7 activation	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	181	0.005524862	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Regulation of gene expression by Hypoxia-inducible Factor	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	119	0.008403361	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Notch-HLH transcription pathway	pathway	pathway	5.81875	16	0.625		5.81875	16.0	0.625	1	147	0.006802721	Untagged	13.0	0.12350597609561753	0.16613274078711932	0.0	0.0012505774552435912
Ca2+ activated K+ channels	pathway	pathway	5.836666667	6	0.666666667		5.836666667	6.0	0.666666667	1	145	0.006896552	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Class A/1 (Rhodopsin-like receptors)	pathway	pathway	5.85843591	75	0.694444444		5.85843591	75.0	0.694444444	2	199	0.010050251	Untagged	3.0	0.5714285714285714	0.7083333333333333	3.0	0.003352731029970611
Muscarinic acetylcholine receptors	pathway	pathway	5.937875599	104	0.5		5.937875599	104.0	0.5	1	58	0.017241379	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Activation of E2F1 target genes at G1/S	pathway	pathway	5.94374298	10933	0.700171356		5.94374298	10933.0	0.700171356	6	37	0.162162162	Untagged	9.0	0.20686367969494757	0.2720503255065472	8463.739646318625	0.00484284554296395
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	pathway	pathway	5.955110955	200	0.573589296		5.955110955	200.0	0.573589296	2	52	0.038461538	Untagged	8.0	0.21428571428571427	0.26734360410831	50.0	0.00279015952582251
Phenylalanine and tyrosine catabolism	pathway	pathway	6.033998098	27	0.703703704		6.033998098	27.0	0.703703704	1	206	0.004854369	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Role of phospholipids in phagocytosis	pathway	pathway	6.06569697	43930	0.725407925		6.06569697	43930.0	0.725407925	2	578	0.003460208	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
mRNA Splicing - Minor Pathway	pathway	pathway	6.081626853	53	0.698113208		6.081626853	53.0	0.698113208	1	1014	9.86193E-4	Untagged	4.0	0.4	0.5555555555555556	0.5	0.002625139550160599
RIPK1-mediated regulated necrosis	pathway	pathway	6.110255909	263	0.664219285		6.110255909	263.0	0.664219285	2	167	0.011976048	Untagged	11.0	0.14136807817589578	0.16957810494676884	0.5	0.0019036038780019609
TNFR1-induced NFkappaB signaling pathway	pathway	pathway	6.110255909	263	0.664219285		6.110255909	263.0	0.664219285	2	290	0.006896552	Untagged	11.0	0.14136807817589578	0.16957810494676884	0.5	0.0019036038780019609
Regulation of TNFR1 signaling	pathway	pathway	6.110255909	263	0.664219285		6.110255909	263.0	0.664219285	2	325	0.006153846	Untagged	11.0	0.14136807817589578	0.16957810494676884	0.5	0.0019036038780019609
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	pathway	pathway	6.110255909	263	0.664219285		6.110255909	263.0	0.664219285	2	157	0.012738854	Untagged	11.0	0.14136807817589578	0.16957810494676884	0.5	0.0019036038780019609
Regulation of necroptotic cell death	pathway	pathway	6.110255909	263	0.664219285		6.110255909	263.0	0.664219285	2	66	0.03030303	Untagged	11.0	0.14136807817589578	0.16957810494676884	0.5	0.0019036038780019609
Amine ligand-binding receptors	pathway	pathway	6.12	4	0.5		6.12	4.0	0.5	1	40	0.025	Untagged	4.0	0.35714285714285715	0.4666666666666667	0.0	0.0017968114881994888
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	pathway	pathway	6.133861552	351	0.710809173		6.133861552	351.0	0.710809173	7	1750	0.004	Untagged	10.0	0.18098415346121768	0.2387151634847493	1315.249419002052	0.004723554427030849
Interleukin-4 and 13 signaling	pathway	pathway	6.163846248	27950	0.766508954		6.163846248	27950.0	0.766508954	9	258	0.034883721	Untagged	8.0	0.24913892078071181	0.3398178626289223	12915.301211507782	0.007722897526414495
Urea cycle	pathway	pathway	6.168845663	113	0.921875		6.168845663	113.0	0.921875	2	149	0.013422819	Untagged	1.0	1.0	1.0	1.0	0.003978809110339699
Platelet degranulation	pathway	pathway	6.231365403	61569	0.770119114		6.231365403	61569.0	0.770119114	7	2275	0.003076923	Untagged	10.0	0.18189438390611903	0.24462914197937294	1080.879453149191	0.005378518520226369
Post-translational protein phosphorylation	pathway	pathway	6.232243012	270	0.6761455		6.232243012	270.0	0.6761455	5	1589	0.003146633	Untagged	10.0	0.18038237738985868	0.2344908931314467	885.2494190020501	0.003685710892281156
Negative regulation of MAPK pathway	pathway	pathway	6.263333333	15	0.75		6.263333333	15.0	0.75	3	494	0.006072874	Untagged	5.0	0.40476190476190477	0.4601307189542483	650.0	0.0025673186508980866
Interleukin-1 family signaling	pathway	pathway	6.282459795	42224	0.972985348		6.282459795	42224.0	0.972985348	8	1108	0.007220217	Untagged	8.0	0.2104752667313288	0.24810730743910495	4779.400849150847	0.00598161224350624
Regulation of TP53 Activity through Phosphorylation	pathway	pathway	6.315222821	200	0.616666667		6.315222821	200.0	0.616666667	3	964	0.003112033	Untagged	11.0	0.1585098612125639	0.21018047492701927	1323.5673076923074	0.002414495144805186
Ub-specific processing proteases	pathway	pathway	6.347540025	45832	0.956608836		6.347540025	45832.0	0.956608836	9	2743	0.003281079	Untagged	9.0	0.193923145665773	0.2584558554604641	5182.450299700297	0.008487355747571564
HDMs demethylate histones	pathway	pathway	6.35	3	1.0		6.35	3.0	1.0	2	235	0.008510638	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Role of LAT2/NTAL/LAB on calcium mobilization	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	429	0.002331002	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
GAB1 signalosome	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	168	0.005952381	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Nephrin family interactions	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	180	0.005555556	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Interleukin-3, 5 and GM-CSF signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	221	0.004524887	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
DAP12 signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	386	0.002590674	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
G beta:gamma signalling through PI3Kgamma	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	319	0.003134796	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PIP3 activates AKT signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	1096	9.12409E-4	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Rho GTPase cycle	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	2261	4.42282E-4	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI3K events in ERBB4 signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	131	0.007633588	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI3K events in ERBB2 signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	243	0.004115226	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by FGFR1 in disease	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	35	0.028571429	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
G alpha (12/13) signalling events	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	1122	8.91266E-4	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI-3K cascade:FGFR4	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	258	0.003875969	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by FGFR3 fusions in cancer	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	10	0.1	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
CD28 dependent PI3K/Akt signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	247	0.004048583	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by FGFR2 in disease	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	30	0.033333333	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Regulation of signaling by CBL	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	222	0.004504505	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI3K/AKT activation	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	124	0.008064516	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI-3K cascade:FGFR2	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	328	0.00304878	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Interleukin-7 signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	266	0.003759398	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
RET signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	446	0.002242152	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI3K Cascade	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	525	0.001904762	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
GPVI-mediated activation cascade	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	568	0.001760563	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI-3K cascade:FGFR1	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	269	0.003717472	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Costimulation by the CD28 family	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	71	0.014084507	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by FGFR4 in disease	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	11	0.090909091	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by cytosolic FGFR1 fusion mutants	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	18	0.055555556	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Tie2 Signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	257	0.003891051	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Downstream signal transduction	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	395	0.002531646	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Signaling by FGFR3 point mutants in cancer	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	24	0.041666667	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Interleukin receptor SHC signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	265	0.003773585	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
PI-3K cascade:FGFR3	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	250	0.004	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
MET activates PI3K/AKT signaling	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	89	0.011235955	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Constitutive Signaling by Aberrant PI3K in Cancer	pathway	pathway	6.352121212	27456	0.656759907		6.352121212	27456.0	0.656759907	1	74	0.013513514	Untagged	10.0	0.17830731306491374	0.23791419793723978	0.0	0.0014185996128081506
Regulation of APC/C activators between G1/S and early anaphase	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	386	0.002590674	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Cyclin E associated events during G1/S transition	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	185	0.005405405	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Processing of DNA double-strand break ends	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	824	0.001213592	Untagged	11.0	0.15713251267197684	0.20380566693930804	430.0	0.002597281611620672
Cyclin A:Cdk2-associated events at S phase entry	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	214	0.004672897	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Meiotic recombination	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	82	0.012195122	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
G2 Phase	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	82	0.012195122	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Activation of ATR in response to replication stress	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	542	0.001845018	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	52	0.019230769	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Regulation of TP53 Degradation	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	387	0.002583979	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
p53-Dependent G1 DNA Damage Response	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	68	0.014705882	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
PTK6 Regulates Cell Cycle	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	27	0.037037037	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	3	0.333333333	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
Activation of the pre-replicative complex	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	589	0.001697793	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	pathway	pathway	6.375077591	24	0.5		6.375077591	24.0	0.5	1	97	0.010309278	Untagged	11.0	0.15667870036101084	0.19958139658600546	0.0	0.0013592634274590906
RUNX3 Regulates Immune Response and Cell Migration	pathway	pathway	6.38	4	1.0		6.38	4.0	1.0	1	9	0.111111111	Untagged	12.0	0.13777777777777778	0.16349488964696357	0.0	0.0013187812806704088
Interferon alpha/beta signaling	pathway	pathway	6.412302652	7224	1.0		6.412302652	7224.0	1.0	2	291	0.006872852	Untagged	9.0	0.16782675947409126	0.1868572160046821	0.3333333333333333	0.0019248433729375496
Respiratory electron transport	pathway	pathway	6.43	3	1.0		6.43	3.0	1.0	3	678	0.004424779	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Gluconeogenesis	pathway	pathway	6.495	8	0.785714286		6.495	8.0	0.785714286	2	663	0.003016591	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
p130Cas linkage to MAPK signaling for integrins	pathway	pathway	6.540422228	35	0.746590909		6.540422228	35.0	0.746590909	4	276	0.014492754	Untagged	10.0	0.18219983207388749	0.24194096993636222	543.1964729714734	0.0034201033369954037
GRB2:SOS provides linkage to MAPK signaling for Integrins	pathway	pathway	6.540422228	35	0.746590909		6.540422228	35.0	0.746590909	4	293	0.013651877	Untagged	10.0	0.18219983207388749	0.24194096993636222	543.1964729714734	0.0034201033369954037
Integrin alphaIIb beta3 signaling	pathway	pathway	6.540422228	35	0.746590909		6.540422228	35.0	0.746590909	4	396	0.01010101	Untagged	10.0	0.18219983207388749	0.24194096993636222	543.1964729714734	0.0034201033369954037
Platelet Adhesion to exposed collagen	pathway	pathway	6.666396304	20	0.878787879		6.666396304	20.0	0.878787879	2	99	0.02020202	Untagged	10.0	0.1806827643630308	0.23069453587886823	116.96067134619766	0.0019274821571843982
Transport of organic anions	pathway	pathway	6.670108202	2	1.0		6.670108202	2.0	1.0	1	152	0.006578947	Untagged	1.0	1.0	1.0	3.0	0.005230965271077875
Potassium transport channels	pathway	pathway	6.675085035	454	0.533039648		6.675085035	454.0	0.533039648	1	59	0.016949153	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Release	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Uncoating of the Influenza Virion	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Budding	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Entry of Influenza Virion into Host Cell via Endocytosis	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	11	0.090909091	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Influenza Life Cycle	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Viral mRNA Translation	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	101	0.00990099	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Packaging of Eight RNA Segments	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	3	0.333333333	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Assembly of Viral Components at the Budding Site	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	7	0.142857143	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Fusion of the Influenza Virion to the Host Cell Endosome	pathway	pathway	6.684444444	9	0.555555556		6.684444444	9.0	0.555555556	1	9	0.111111111	Untagged	12.0	0.1337030191004313	0.16354060685857932	0.0	0.0014870077772062198
Cell surface interactions at the vascular wall	pathway	pathway	6.691659626	24	0.875		6.691659626	24.0	0.875	4	978	0.00408998	Untagged	10.0	0.18562874251497005	0.2458580206276064	492.51265284423215	0.0036700898176740444
Pyrimidine biosynthesis	pathway	pathway	6.702516485	6	1.0		6.702516485	6.0	1.0	1	67	0.014925373	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	pathway	pathway	6.848148148	17	0.851851852		6.848148148	17.0	0.851851852	3	951	0.003154574	Untagged	10.0	0.1791907514450867	0.23438117182356863	2357.20303030303	0.0031794339910998235
Synthesis of PC	pathway	pathway	6.886666667	22	0.833333333		6.886666667	22.0	0.833333333	2	448	0.004464286	Untagged	13.0	0.12156862745098039	0.14807078482193678	0.0	0.001464229659786324
VEGF ligand-receptor interactions	pathway	pathway	6.957936508	63	0.825396825		6.957936508	63.0	0.825396825	1	62	0.016129032	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
VEGF binds to VEGFR leading to receptor dimerization	pathway	pathway	6.957936508	63	0.825396825		6.957936508	63.0	0.825396825	1	99	0.01010101	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
Chylomicron clearance	pathway	pathway	6.987494665	358	0.558659218		6.987494665	358.0	0.558659218	1	61	0.016393443	Untagged	5.0	0.2857142857142857	0.3729166666666667	0.0	0.0017472045995132648
Metabolism of folate and pterines	pathway	pathway	7.04326027	488	0.592213115		7.04326027	488.0	0.592213115	1	313	0.003194888	Untagged	9.0	0.17714285714285713	0.19294126252651675	0.0	0.0013062955423351714
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	pathway	pathway	7.050651763	79	0.594936709		7.050651763	79.0	0.594936709	1	150	0.006666667	Untagged	12.0	0.13321055862492326	0.15439899322387812	0.0	0.0014468414771899216
HIV elongation arrest and recovery	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	36	0.027777778	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Formation of HIV-1 elongation complex containing HIV-1 Tat	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	47	0.021276596	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Tat-mediated elongation of the HIV-1 transcript	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	45	0.022222222	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
RNA Polymerase II Transcription Elongation	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	788	0.001269036	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Formation of RNA Pol II elongation complex	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	614	0.001628664	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
TP53 Regulates Transcription of DNA Repair Genes	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	902	0.001108647	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Tat-mediated HIV elongation arrest and recovery	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	35	0.028571429	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Formation of HIV elongation complex in the absence of HIV Tat	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	48	0.020833333	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Pausing and recovery of Tat-mediated HIV elongation	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	35	0.028571429	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Interactions of Tat with host cellular proteins	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	3	0.333333333	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Pausing and recovery of HIV elongation	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	36	0.027777778	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
RNA Polymerase II Pre-transcription Events	pathway	pathway	7.12735333	12	0.666666667		7.12735333	12.0	0.666666667	1	1447	6.91085E-4	Untagged	2.0	0.5217391304347826	0.5416666666666666	0.0	0.0015788431355915264
Assembly of active LPL and LIPC lipase complexes	pathway	pathway	7.134212449	401	0.593283097		7.134212449	401.0	0.593283097	2	92	0.02173913	Untagged	3.0	0.5	0.5833333333333334	12.0	0.002951877764504914
Signaling by NODAL	pathway	pathway	7.280930233	43	0.627906977		7.280930233	43.0	0.627906977	1	120	0.008333333	Untagged	4.0	0.4	0.46875000000000006	0.0	0.001613671107431878
NGF processing	pathway	pathway	7.280930233	43	0.627906977		7.280930233	43.0	0.627906977	1	64	0.015625	Untagged	4.0	0.4	0.46875000000000006	0.0	0.001613671107431878
Platelet sensitization by LDL	pathway	pathway	7.291962102	163	0.8		7.291962102	163.0	0.8	2	133	0.015037594	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Basigin interactions	pathway	pathway	7.31875	1442	1.0		7.31875	1442.0	1.0	2	362	0.005524862	Untagged	10.0	0.1757085020242915	0.21863616414307713	216.0	0.0024099723126113108
ECM proteoglycans	pathway	pathway	7.366619105	12	0.958333333		7.366619105	12.0	0.958333333	4	575	0.006956522	Untagged	10.0	0.18562874251497005	0.2439378977397416	264.22793347003886	0.0026283780655050764
PECAM1 interactions	pathway	pathway	7.47	4	1.0		7.47	4.0	1.0	1	12	0.083333333	Untagged	12.0	0.13937058445728967	0.17225065001562734	0.0	0.0011311708437438885
Cross-presentation of particulate exogenous antigens (phagosomes)	pathway	pathway	7.47	4	1.0		7.47	4.0	1.0	1	129	0.007751938	Untagged	12.0	0.13937058445728967	0.17225065001562734	0.0	0.0011311708437438885
Elastic fibre formation	pathway	pathway	7.473333333	8	1.0		7.473333333	8.0	1.0	2	194	0.010309278	Untagged	10.0	0.1806827643630308	0.23069453587886823	104.83043214095841	0.001913813719407312
Laminin interactions	pathway	pathway	7.4775	8	1.0		7.4775	8.0	1.0	2	364	0.005494505	Untagged	10.0	0.1806827643630308	0.23069453587886823	104.83043214095841	0.001913813719407312
MET interacts with TNS proteins	pathway	pathway	7.48	4	1.0		7.48	4.0	1.0	1	73	0.01369863	Untagged	10.0	0.17542441390460792	0.21556396752249343	0.0	0.0011916408181036522
Smooth Muscle Contraction	pathway	pathway	7.48	4	1.0		7.48	4.0	1.0	1	549	0.001821494	Untagged	10.0	0.17542441390460792	0.21556396752249343	0.0	0.0011916408181036522
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	pathway	pathway	7.48	4	1.0		7.48	4.0	1.0	1	38	0.026315789	Untagged	10.0	0.17542441390460792	0.21556396752249343	0.0	0.0011916408181036522
CHL1 interactions	pathway	pathway	7.48	4	1.0		7.48	4.0	1.0	1	16	0.0625	Untagged	10.0	0.17542441390460792	0.21556396752249343	0.0	0.0011916408181036522
Other semaphorin interactions	pathway	pathway	7.48	4	1.0		7.48	4.0	1.0	1	156	0.006410256	Untagged	10.0	0.17542441390460792	0.21556396752249343	0.0	0.0011916408181036522
Disassembly of the destruction complex and recruitment of AXIN to the membrane	pathway	pathway	7.640014411	12	0.777777778		7.640014411	12.0	0.777777778	2	224	0.008928571	Untagged	6.0	0.3227848101265823	0.3781045751633987	410.0	0.0025088890754428423
Fibronectin matrix formation	pathway	pathway	7.67125	8	0.875		7.67125	8.0	0.875	2	129	0.015503876	Untagged	10.0	0.18468085106382978	0.2385615536537201	94.37022860180757	0.0019062051642014166
MET activates PTK2 signaling	pathway	pathway	7.67125	8	0.875		7.67125	8.0	0.875	2	391	0.00511509	Untagged	10.0	0.18468085106382978	0.2385615536537201	94.37022860180757	0.0019062051642014166
Cyclin D associated events in G1	pathway	pathway	7.83	2	1.0		7.83	2.0	1.0	2	519	0.003853565	Untagged	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Non-integrin membrane-ECM interactions	pathway	pathway	7.8625	4	0.75		7.8625	4.0	0.75	1	294	0.003401361	Untagged	10.0	0.17772317772317772	0.2188994952819844	0.0	0.001123562288537993
Extracellular matrix organization	pathway	pathway	7.8625	4	0.75		7.8625	4.0	0.75	1	178	0.005617978	Untagged	10.0	0.17772317772317772	0.2188994952819844	0.0	0.001123562288537993
Receptor Mediated Mitophagy	pathway	pathway	8.0	16	0.75		8.0	16.0	0.75	1	129	0.007751938	Untagged	13.0	0.12156862745098039	0.14807078482193678	0.0	0.001464229659786324
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	pathway	pathway	8.0	16	0.75		8.0	16.0	0.75	1	505	0.001980198	Untagged	13.0	0.1271236086701816	0.16349211464418859	120.34615384615381	0.002426652085912232
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	pathway	pathway	8.0	16	0.75		8.0	16.0	0.75	1	424	0.002358491	Untagged	13.0	0.12156862745098039	0.14807078482193678	0.0	0.001464229659786324
Condensation of Prometaphase Chromosomes	pathway	pathway	8.0	16	0.75		8.0	16.0	0.75	1	157	0.006369427	Untagged	13.0	0.12156862745098039	0.14807078482193678	0.0	0.001464229659786324
WNT mediated activation of DVL	pathway	pathway	8.0	16	0.75		8.0	16.0	0.75	1	113	0.008849558	Untagged	13.0	0.12156862745098039	0.14807078482193678	0.0	0.001464229659786324
Cytosolic tRNA aminoacylation	pathway	pathway	8.235	2	1.0		8.235	2.0	1.0	1	47	0.021276596	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
SeMet incorporation into proteins	pathway	pathway	8.235	2	1.0		8.235	2.0	1.0	1	11	0.090909091	Untagged	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
G alpha (s) signalling events	pathway	pathway	8.576666667	7	0.833333333		8.576666667	7.0	0.833333333	3	1441	0.002081888	Untagged	2.0	0.625	0.7	6.0	0.003127038360082922
BBSome-mediated cargo-targeting to cilium	pathway	pathway	8.66	25	1.0		8.66	25.0	1.0	1	147	0.006802721	Untagged	1.0	1.0	1.0	0.0	0.0027266529496015224
NGF-independant TRKA activation	pathway	pathway	9.76	2	1.0		9.76	2.0	1.0	1	15	0.066666667	Untagged	4.0	0.4166666666666667	0.5166666666666666	0.0	0.0017392248143236618
Glucagon-type ligand receptors	pathway	pathway	9.805	3	1.0		9.805	3.0	1.0	2	282	0.007092199	Untagged	4.0	0.4166666666666667	0.5166666666666666	0.0	0.0017392248143236618
CTLA4 inhibitory signaling	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	221	0.004524887	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
S37 mutants of beta-catenin aren't phosphorylated	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	15	0.066666667	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	1119	8.93655E-4	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Beta-catenin phosphorylation cascade	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	201	0.004975124	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
APC truncation mutants have impaired AXIN binding	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	14	0.071428571	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
S33 mutants of beta-catenin aren't phosphorylated	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	15	0.066666667	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
T41 mutants of beta-catenin aren't phosphorylated	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	15	0.066666667	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
S45 mutants of beta-catenin aren't phosphorylated	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	15	0.066666667	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
AXIN missense mutants destabilize the destruction complex	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	14	0.071428571	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Misspliced GSK3beta mutants stabilize beta-catenin	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	15	0.066666667	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
RAF activation	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	356	0.002808989	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Truncations of AMER1 destabilize the destruction complex	pathway	pathway	10.01333333	3	1.0		10.01333333	3.0	1.0	1	14	0.071428571	Untagged	6.0	0.28651685393258425	0.3300653594771242	0.0	0.0014833944188588312
Vacuolar protein sorting-associated protein 35	target	unclassified	5.0	2	0.5	Prediction							prediction	9.0	0.17832167832167833	0.21382664176781815	0.0	0.0014777365348097333
Uroporphyrinogen-III synthase	target	enzyme	5.0	11	0.909090909	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
V-type proton ATPase subunit B- brain isoform	target	enzyme hydrolase, transporter ntpase f-type and v-type v-type atpase	5.0	2	1.0	Prediction							prediction	1.0	1.0	1.0	6.0	0.006483121431816054
Complex of retinoic acid binding (CRABPII) and inhibitor of apoptosis (cIAP1) proteins	target	auxiliary transport protein fabp, enzyme	5.0	36	0.777777778	Prediction							prediction	10.0	0.1642694928084784	0.21443018067442035	958.5	0.007162323676749802
Kallikrein 8	target	enzyme protease serine pas s1a	5.0	2	1.0	Prediction							prediction	5.0	0.34782608695652173	0.43124999999999997	0.0	0.0016710128302331003
Thioredoxin reductase 2	target	enzyme	5.0	2	1.0	Prediction							prediction	13.0	0.11851447296559257	0.13732266197703974	0.0	0.001532687313842023
Splicing factor 3B subunit 2	target	unclassified	5.0	4	0.5	Prediction							prediction	3.0	0.5	0.611111111111111	2.0	0.0026068334618222105
Toll-like receptor 4/MD-2	target	membrane receptor, surface antigen	5.0	120	1.0	Prediction							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Toll-like receptor 4/MD-2/CD14	target	membrane receptor, surface antigen	5.0	9	1.0	Prediction							prediction	1.0	1.0	1.0	3.0	0.005230965271077875
Heme oxygenase 1	target	enzyme	5.0	3	1.0	Actual							prediction	9.0	0.20036934441366575	0.2476373345036941	431.0	0.0037120795769695313
Cofilin-1	target	unclassified	5.0	4	0.5	Actual							prediction	11.0	0.15444839857651246	0.19318264940384727	431.0	0.003599172380765105
Mitogen-activated protein kinase; ERK1/ERK2	target	enzyme kinase protein kinase cmgc mapk erk	5.0	8	0.5	Actual							prediction	6.0	0.40476190476190477	0.625816993464052	947.0	0.03057819450009074
ORAI 1/2/3	target	ion channel other misc crac-c	5.007619048	567	0.761904762	Prediction							prediction	11.0	0.15206727400140155	0.18934788969351155	216.0	0.0029664986849140713
Histone deacetylase	target	enzyme, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv	5.025864087	10364	0.591084523	Actual							prediction	10.0	0.18281381634372368	0.27644466388706135	5018.745499967898	0.01333964209376289
von Willebrand factor	target	unclassified	5.039188911	22	0.636363636	Prediction							prediction	11.0	0.17181314330958036	0.2436983395508743	688.9271493126757	0.006055333579376479
Integrin alpha M	target	membrane receptor	5.044138505	12	0.75	Prediction							prediction	9.0	0.20074005550416282	0.2463316509399459	126.15833333333343	0.0020083093729401863
Heat shock factor protein 1	target	unclassified	5.055052677	30	0.6	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Interleukin-1 beta	target	secreted	5.107142857	7	0.714285714	Prediction							prediction	9.0	0.218970736629667	0.270923853412333	5211.232350982347	0.005291491197525053
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II	target	enzyme reductase	5.11	3	0.666666667	Prediction							prediction	1.0	1.0	1.0	3.0	0.005230965271077875
Protein disulfide-isomerase	target	enzyme	5.16416382	9	0.777777778	Actual							prediction	11.0	0.15488936473947182	0.20401214249140504	1280.75	0.007678218117811655
Purinergic receptor P2Y12	target	membrane receptor 7tm1 smallmol nucleotide-like receptor purine receptor	5.2	2	0.5	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Protein Wnt-3a	target	unclassified	5.26669549	9	0.555555556	Actual							prediction	7.0	0.26842105263157895	0.3593370681605978	405.0	0.007234946911463422
Galectin-1	target	cytosolic other	5.268614844	37	0.648648649	Prediction							prediction	11.0	0.15357395612172683	0.1874990856557673	0.75	0.0019942089552043747
Hypoxanthine-guanine phosphoribosyltransferase	target	enzyme	5.320709495	5	0.6	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Histone-lysine N-methyltransferase NSD2	target	epigenetic regulator writer pmt set	5.348926307	24	0.5	Actual							prediction	12.0	0.1360501567398119	0.16602396579355086	216.0	0.002911846263284332
Ribonucleoside-diphosphate reductase M2 chain	target	enzyme	5.375164097	6	0.666666667	Actual							prediction	10.0	0.17181314330958036	0.20670580059980978	216.0	0.0022577474847268555
Serum amyloid P-component	target	secreted	5.414645637	2	1.0	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Solute carrier organic anion transporter family member 4A1	target	transporter electrochemical slc slc21	5.436285611	2	0.5	Prediction							prediction	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Tubulin beta-1 chain	target	structural	5.448571429	7	0.857142857	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Tubulin	target	structural	5.456414547	61409	0.883502418	Actual							prediction	11.0	0.1540099361249113	0.18703825616267977	0.0	0.0011704275229214062
Heterogeneous nuclear ribonucleoprotein A1	target	unclassified	5.52	4	1.0	Actual							prediction	3.0	0.6	0.7222222222222223	9.0	0.004218448085898324
Prolactin receptor	target	unclassified	5.61	2	1.0	Prediction							prediction	8.0	0.2318181818181818	0.2862278244631183	50.0	0.0030350802141954287
Proteasome Macropain subunit	target	enzyme protease threonine pbt t1a	5.653333333	3	1.0	Actual							prediction	8.0	0.20074005550416282	0.22796247531270572	661.2136335886337	0.0018559588557341767
Histone deacetylase (HDAC1 and HDAC2)	target	epigenetic regulator eraser hdac hdac class i	5.7	4	1.0	Actual							prediction	10.0	0.1791907514450867	0.24779643040011765	1077.5952380952372	0.007466916810915321
Sphingosine 1-phosphate receptor Edg-5	target	membrane receptor 7tm1 smallmol lipid-like ligand receptor edg receptor	5.74	2	1.0	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Histone deacetylase 3	target	epigenetic regulator eraser hdac hdac class i	5.741160217	16	0.75	Actual							prediction	12.0	0.13795295613477432	0.18712885936388224	22.7222222222222	0.004628750135250316
Proline-rich AKT1 substrate 1	target	unclassified	5.75	4	0.5	Prediction							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
G-protein coupled receptor 55	target	membrane receptor 7tm1 smallmol lipid-like ligand receptor lysophosphatidylinositol receptor	5.783333333	3	0.666666667	Actual							prediction	4.0	0.4	0.5208333333333333	0.0	0.0018342001576266544
Ras-related protein Rap-1A	target	unclassified	5.79	5	0.6	Prediction							prediction	11.0	0.15577889447236182	0.20808280301367854	1070.75	0.00788704757135434
CREB-binding protein	target	epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp	5.81875	16	0.625	Actual							prediction	12.0	0.14081765087605452	0.23244375951749333	3141.774493927125	0.019790234611574017
Small conductance calcium-activated potassium channel protein 3	target	ion channel vgc k ca act k	5.836666667	6	0.666666667	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Orexin receptor 1	target	membrane receptor 7tm1 peptide short peptide orexin receptor	5.845	2	1.0	Actual							prediction	4.0	0.4	0.5208333333333333	0.0	0.0018342001576266544
Galanin receptor 3	target	membrane receptor 7tm1 peptide short peptide galanin receptor	5.884701392	6	0.5	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Chymase	target	enzyme protease serine pas s1a	5.892917867	3	0.666666667	Actual							prediction	1.0	1.0	1.0	1.0	0.003978809110339699
Heat shock protein HSP 90-alpha	target	cytosolic other	5.933361395	80	0.5625	Actual							prediction	7.0	0.23561346362649294	0.29343866578889677	7818.986330336363	0.01347885915407883
Cannabinoid CB1 receptor/orexin receptor 1 complex	target	membrane receptor 7tm1 peptide short peptide orexin receptor, membrane receptor 7tm1 smallmol lipid-like ligand receptor cannabinoid receptor	5.933538486	72	0.722222222	Prediction							prediction	2.0	0.6666666666666666	0.75	4.0	0.00325940237281308
Muscarinic acetylcholine receptor M1/M5 chimeric protein	target	membrane receptor 7tm1 smallmol monoamine receptor acetylcholine receptor	5.937875599	104	0.5	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Nuclear receptor coactivator 3	target	epigenetic regulator writer hat src	5.976518006	11	0.636363636	Actual							prediction	12.0	0.13708149084017687	0.1717678762609636	0.0	0.0011403613828064518
E3 SUMO-protein ligase CBX4	target	enzyme	5.985	2	0.5	Prediction							prediction	12.0	0.13673597983616886	0.17047316482800323	160.27884615384613	0.0022633112756610795
Corticotropin-releasing factor-binding protein	target	unclassified	6.0	6	0.5	Prediction							prediction	9.0	0.17832167832167833	0.21382664176781815	0.0	0.0014777365348097333
Tyrosine aminotransferase	target	enzyme	6.033998098	27	0.703703704	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Splicing factor 3B subunit 3	target	unclassified	6.081626853	53	0.698113208	Prediction							prediction	3.0	0.5	0.611111111111111	2.0	0.0026068334618222105
Proto-oncogene protein Wnt-3	target	unclassified	6.088464139	142	0.514084507	Prediction							prediction	9.0	0.18085106382978725	0.23180049797696844	2.0	0.002546475127179238
Tubulin beta-2 chain	target	structural	6.095399215	2	1.0	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Trace amine-associated receptor 1	target	membrane receptor 7tm1 smallmol monoamine receptor trace amine receptor	6.12	4	0.5	Actual							prediction	3.0	0.5	0.6333333333333334	4.0	0.0032643461240343123
Arginase-1	target	enzyme	6.126875	64	0.84375	Prediction							prediction	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
Solute carrier organic anion transporter family member 1C1	target	transporter electrochemical slc slc21, unclassified	6.139606779	6	0.5	Prediction							prediction	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
Histone deacetylase 1	target	enzyme, epigenetic regulator eraser hdac hdac class i	6.143091837	47	0.85106383	Actual							prediction	10.0	0.1791907514450867	0.24779643040011765	1077.5952380952372	0.007466916810915321
Arginase-2- mitochondrial	target	enzyme	6.210816327	49	1.0	Prediction							prediction	2.0	0.6666666666666666	0.75	0.0	0.0021005748692324343
26S proteosome	target	enzyme, enzyme protease threonine pbt t1a, unclassified	6.251	7220	1.0	Actual							prediction	8.0	0.20111214087117701	0.2310346719332895	768.7136335886338	0.00267362323680688
COUP transcription factor 2	target	transcription factor nuclear receptor nr2 nr2f nr2f2	6.289952038	6	0.833333333	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
PI3-kinase class I	target	enzyme, unclassified	6.352121212	27456	0.656759907	Prediction							prediction	9.0	0.21678321678321677	0.36484163557896315	7793.66224608724	0.04747733483826884
CDK2/Cyclin A1	target	cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2	6.375077591	24	0.5	Prediction							prediction	10.0	0.18562874251497005	0.2795388047692199	5955.891483516486	0.0201132453842807
Leukocyte adhesion glycoprotein LFA-1 alpha	target	adhesion, membrane receptor	6.38	4	1.0	Actual							prediction	11.0	0.15967623252391464	0.20280520810474711	276.43636363636375	0.0032089709739432084
Proteasome component C5	target	enzyme protease threonine pbt t1a	6.39	3	1.0	Actual							prediction	8.0	0.20074005550416282	0.22796247531270572	661.2136335886337	0.0018559588557341767
Proteasome subunit beta type-8	target	enzyme protease threonine pbt t1a	6.573605303	4	1.0	Actual							prediction	8.0	0.20111214087117701	0.2310346719332895	768.7136335886338	0.00267362323680688
Lysine-specific demethylase 5A	target	epigenetic regulator eraser kdm jumonji, epigenetic regulator reader phd	6.6	2	1.0	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Secreted frizzled-related protein 1	target	unclassified	6.643526421	191	0.591623037	Prediction							prediction	9.0	0.17708333333333334	0.20892468098350445	0.0	0.0015942871678883384
Solute carrier organic anion transporter family member 4C1	target	transporter electrochemical slc slc21	6.670108202	2	1.0	Actual							prediction	2.0	0.6	0.6666666666666666	0.0	0.0018918821757760705
ATP-sensitive inward rectifier potassium channel 1	target	ion channel vgc k kir, unclassified	6.675085035	454	0.533039648	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Hemagglutinin	target	unclassified	6.684444444	9	0.555555556	Prediction							prediction	11.0	0.15422885572139303	0.213245190549338	2115.0	0.013942300462282198
Dihydroorotate dehydrogenase	target	enzyme, enzyme reductase	6.702516485	6	1.0	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Prostasin	target	enzyme protease serine pas s1a	6.707826087	23	0.608695652	Prediction							prediction	5.0	0.34782608695652173	0.43124999999999997	0.0	0.0016710128302331003
Non-secretory ribonuclease	target	enzyme	6.74	2	0.5	Prediction							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Glucose-6-phosphate translocase	target	transporter electrochemical slc slc37	6.75	7	0.571428571	Prediction							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Sodium/potassium-transporting ATPase alpha-1 chain	target	enzyme hydrolase, transporter ntpase p-type atpase na k atpase	6.9	6	1.0	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Placenta growth factor	target	unclassified	6.957936508	63	0.825396825	Prediction							prediction	1.0	1.0	1.0	1.0	0.003978809110339699
Hepatic lipase	target	enzyme	6.987494665	358	0.558659218	Prediction							prediction	4.0	0.38095238095238093	0.5	7.0	0.003148377893225996
Dihydrofolate reductase	target	enzyme, enzyme reductase, unclassified	7.04326027	488	0.592213115	Actual							prediction	8.0	0.21506442021803765	0.24420122887864845	6621.932484182508	0.003164981939637638
Prostate specific antigen	target	enzyme protease serine pas s1a	7.050651763	79	0.594936709	Prediction							prediction	11.0	0.15357395612172683	0.1874990856557673	216.0	0.002440823649304329
Potassium-transporting ATPase alpha chain 2	target	enzyme hydrolase, transporter ntpase p-type atpase h k atpase	7.1	2	1.0	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
CDK9/Cyclin K	target	enzyme kinase protein kinase cmgc cdk cdk9, unclassified	7.12735333	12	0.666666667	Prediction							prediction	1.0	1.0	1.0	66.0	0.016500370717721466
Baculoviral IAP repeat-containing protein 3	target	enzyme	7.220511817	227	0.550660793	Prediction							prediction	10.0	0.16377358490566038	0.2082857874332528	527.5	0.005173433667284805
Sodium/potassium-transporting ATPase	target	enzyme hydrolase, ion channel other plm, transporter ntpase p-type atpase na k atpase	7.265	960	1.0	Actual							prediction	11.0	0.14955203308063406	0.1746123180454974	0.0	0.001432686450426878
Subtilisin/kexin type 6	target	enzyme protease serine sb s8b	7.280930233	43	0.627906977	Prediction							prediction	3.0	0.6153846153846154	0.7291666666666666	22.0	0.005668364405452068
Tankyrase 1/2	target	enzyme	7.42	8	0.5	Prediction							prediction	10.0	0.16254681647940075	0.19292480433033388	0.0	0.0011300293879135217
Integrin alpha-V/beta-3	target	membrane receptor	7.47	4	1.0	Actual							prediction	11.0	0.16181953765846382	0.22469460902640617	600.8096225412013	0.007640881956802024
Integrin alpha1/beta1 complex	target	membrane receptor	7.48	4	1.0	Prediction							prediction	9.0	0.21253672869735554	0.29886621315192735	4898.204734154734	0.013801601308931261
Proteasome subunit beta type-7	target	unclassified	7.698970004	8	1.0	Prediction							prediction	8.0	0.20074005550416282	0.22796247531270572	661.2136335886337	0.0018559588557341767
Proteasome Macropain subunit MB1	target	enzyme protease threonine pbt t1a	7.703082613	11	1.0	Actual							prediction	8.0	0.20074005550416282	0.22796247531270572	661.2136335886337	0.0018559588557341767
Proteinase-activated receptor 2	target	membrane receptor 7tm1 peptide protease-activated receptor, membrane receptor 7tm1 peptide protease-activated receptor protease-activated receptor	7.745	4	1.0	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Fibronectin	target	adhesion	7.8625	4	0.75	Prediction							prediction	9.0	0.21592039800995025	0.30378172774486173	6049.01643604933	0.011760497212861456
Casein kinase II alpha/beta	target	enzyme kinase protein kinase other ck2, enzyme kinase reg	8.0	16	0.75	Prediction							prediction	12.0	0.1383046526449968	0.18660768315146173	1234.5673076923074	0.008685825705168286
Kininogen-1	target	unclassified	8.066290323	124	0.620967742	Prediction							prediction	11.0	0.15667870036101084	0.20070953112427742	46.93181818181819	0.0027556385356855523
Tubulin beta-3 chain	target	structural	8.1675	4	1.0	Actual							prediction	0.0	0.0	0.0	0.0	4.0899794244022864E-4
Arginyl-tRNA synthetase	target	enzyme	8.235	2	1.0	Prediction							prediction	1.0	1.0	1.0	1.0	0.003978809110339699
Opioid receptors; delta & kappa	target	membrane receptor 7tm1 peptide short peptide opioid receptor	8.263566137	176	0.522727273	Prediction							prediction	9.0	0.19963201471941122	0.24149294126252657	0.0	0.0012289727076142327
Somatostatin receptor	target	membrane receptor 7tm1 peptide short peptide somatostatin receptor	8.66	25	1.0	Actual							prediction	1.0	1.0	1.0	0.0	0.0027266529496015224
Pituitary adenylate cyclase-activating polypeptide	target	unclassified	9.76	2	1.0	Prediction							prediction	3.0	0.625	0.7666666666666666	7.0	0.004693272096645086
Serine/threonine protein phosphatase 2A- 56 kDa regulatory subunit- alpha isoform	target	enzyme phosphatase protein phosphatase reg	10.01333333	3	1.0	Prediction							prediction	5.0	0.3984375	0.5251633986928104	869.0	0.018946388392949917

Best protein/pathway scores with centrality measures