drTarget portfolio 2025

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AIDBioAssay NamegeneprotNameprogramprogramCategoryareadiseaseassayTypeassayModeaddTasksleveltractabilityPoCMLmodelsvirtualScreeningTID/assayIDpathwaysAnalysisgraphsGenerationliteratureCheckwebPublicationDeposit DateModify DateOutcome TypeNumber of Tested CIDsNumber of Active CIDs
720647Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells InhibitionLGR2Leucine-rich repeat-containing G-protein-coupled receptor 2 hyphantria cuneaantiInfectiveantiArthropodalhyphantria cuneacAMPtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/10/201315/01/2015Screening3756481337
11 gram + & - bacterial strains at ChEMBLantibacterialantiInfectiveantibacterial11_bacterialStrainscellDeathphenotypicTID3virtual screening, targetID and repurposing completedcompletedcompletedcompletedunderwaynotStartedunderwaynotStartednotStarted
492967A screen for compounds that inhibit the CapD enzyme of Bacillus anthracisCapDpolysaccharide biosynthesis proteinBacillus anthracisantiInfectiveantibacterialanthraxenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/12/201019/10/2016Other138854320
912qHTS Assay for Anthrax Lethal Toxin InternalizationBacillus anthracis Lethal Toxin InternalizationantiInfectiveantibacterialanthraxtoxinInternalizationphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/12/200712/07/2010Confirmatory68961466
588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound setP15917Lethal Factor ProteaseBacillus anthracis Lethal factor inhibitorsantiInfectiveantibacterialanthraxenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201113/10/2011Screening354794422
several TB strainsTBantiInfectiveantibacterialantibacterialscellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
1490qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)FFP4'-phosphopantetheinyl transferase ffpBacillus subtilisantiInfectiveantibacterialB. subtilisenzymeActtargetBasedphenotypeID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted08/01/200926/01/2010Confirmatory30659910840
651965qHTS Assay for Activators of ClpPCLPPATP-dependent Clp protease proteolytic subunitBacillus subtilis (strain 168)antiInfectiveantibacterialB. subtilisenzymeActtargetBasedphenotypeID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted03/01/201303/01/2013Confirmatory3383786439
588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound setBOTABotulinum neurotoxin type AClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)antiInfectiveantibacterialbotulism enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201114/11/2011Screening354794609
588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound setBoNT/Fbotulinum neurotoxin type FClostridium botulinum toxin inhibitorsantiInfectiveantibacterialbotulism enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201113/10/2011Screening354794780
652162C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_ActivityToxBTcdB glycohydrolaseTcdB glycohydrolaseInhibitorsantiInfectiveantibacterialC. difficileenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/03/201327/03/2013Screening349124837
602405PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_ActivityWLAIPglDCampylobacter jejuniantiInfectiveantibacterialCampylobacter jejunienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201215/03/2012Screening355889350
504770A screen for compounds that inhibit replication of Vibrio cholerae chromosome IIAAF95916Uncharacterized proteinVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)antiInfectiveantibacterialcholera cellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/05/201119/10/2016Other132441351
588436Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_ActivityVibrio cholerae BH1578 strainantiInfectiveantibacterialcholera cellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201104/10/2011Screening349947553
1217uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary AssaysDLDDihydrolipoyl dehydrogenase , Dihydrolipoyl dehydrogenase, mitochondrialDiaphoraseInhibitorsantiInfectiveantibacterialClostridium kluyverienzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/03/200829/09/2010Screening1941521342
1053175A screen for compounds that inhibit growth of Escherichia coliEscherichia coliantiInfectiveantibacterialE. colicellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted26/06/201417/10/2016Other327980699
651602Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage)RECDRecBCD enzyme subunit RecDEscherichia coli (strain K12)antiInfectiveantibacterialE. colienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/201227/09/2012Screening362577949
602123Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon)LONLon proteaseEscherichia coli (strain K12)antiInfectiveantibacterialE. colienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/12/201110/12/2011Screening3620201524
585Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent)AMPCBeta-lactamaseEscherichia coli (strain K12)antiInfectiveantibacterialE. colienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/02/200730/04/2007Confirmatory696681256
485341qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent)AMPCBeta-lactamaseEscherichia coli (strain K12)antiInfectiveantibacterialE. colienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201004/10/2010Confirmatory3306771730
504720uHTS identification of MazEF TA System activators via a fluorescence-based single-stranded RNase assayMAZFEndoribonuclease toxin MazFEscherichia coli (strain K12)antiInfectiveantibacterialE. colitoxinAntitoxin-RNAseActivitytargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/05/201105/05/2011Screening3489231104
2315A qHTS for Small Molecule Inhibitors of Shiga ToxinSTX1rRNA N-glycosylaseEscherichia coli O157:H7antiInfectiveantibacterialE. coliproteinSynthesistargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/02/201004/02/2010Screening29280526874
2314Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga ToxinSTX1rRNA N-glycosylaseEscherichia coli O157:H7antiInfectiveantibacterialE. coliproteinSynthesistargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/02/201004/02/2010Screening29561937013
720706HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_ActivityEscherichia coli ribosomal RNAsantiInfectiveantibacterialE. coliGFP fluorescencephenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201305/03/2014Screening3481285500
573Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTSEscherichia coli ?tolC mutationsantiInfectiveantibacterialE. colicellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted04/01/200704/05/2007Screening650961420
1066High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary ScreenMVAEAcetyl-CoA acetyltransferaseEnterococcus faecalis (Streptococcus faecalis)antiInfectiveantibacterialEnterococcus faecalisenzymeActtargetBasedphenotypeID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted03/03/200814/03/2008Screening194344792
361Pyruvate KinasePYKPyruvate kinaseGeobacillus stearothermophilus (Bacillus stearothermophilus)antiInfectiveantibacterialGeobacillus stearothermophilusenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/01/200631/10/2006Confirmatory51415602
435030Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complexAddABHelicobacter pyloriantiInfectiveantibacterialH. pylorienzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/07/201026/10/2010Screening326024935
449728Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viabilityHelicobacter pyloriantiInfectiveantibacterialH. pyloricellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/07/201027/10/2010Screening326024893
1272365SSB-PriA antibiotic resistant target AlphaScreenSSBsingle-stranded DNA binding protein Klebsiella pneumonia SSB-PriA interactionantiInfectiveantibacterialK. pneumoniaprotProtInteractiontargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted05/09/201822/08/2023Screening4312362568
1020Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary AssayZWFGlucose-6-phosphate 1-dehydrogenaseLeuconostoc mesenteroidesantiInfectiveantibacterialLeuconostoc mesenteroidescounterScreentargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/01/200824/09/2010Screening195560236
2094Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing SystemLUXPAutoinducer 2-binding periplasmic protein LuxPVibrio harveyi (Beneckea harveyi)antiInfectiveantibacterialluminous vibriosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/11/200904/11/2009Screening3021771222
1556Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamaseBLAIMP-1Beta-lactamasePseudomonas aeruginosaantiInfectiveantibacterialP. aeruginosaenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted17/03/200904/01/2013Screening2907261322
488965Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_ActivityPvdQ PvdQ acylasePseudomonas aeruginosaantiInfectiveantibacterialP. aeruginosaenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted28/10/201030/11/2010Screening337500213
1527Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamaseBLAVIM-2Metallo-beta-lactamase type 2Pseudomonas aeruginosaantiInfectiveantibacterialP. aeruginosaenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted25/02/200926/12/2012Screening2907262575
504884Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_ActivitySUPXDNA topoisomerase 1Yersinia pestisantiInfectiveantibacterialplagueenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/06/201118/10/2011Screening356253229
898YopH HTSYopHYersinia outer protein HYersinia pestisantiInfectiveantibacterialplagueenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200718/12/2007Screening139929223
602399uHTS identification of inhibitors of NadD in a Colorimetric assayNaMNATnicotinic acid mononucleotide adenylyltransferaseNadD_inhibitorsantiInfectiveantibacterialS. aureusenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201220/06/2012Screening3620632815
463173A screen for compounds that inhibit cell wall-associated teichoic acid synthesis in Staphylococcus aureusStaphylococcus aureusantiInfectiveantibacterialS. aureuscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted30/08/201019/10/2016Screening517394434
720641A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureusLtaSLipoteichoic acid (LTA) synthaseStaphylococcus aureusantiInfectiveantibacterialS. aureusenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted19/09/201302/11/2016Other168223878
1259311A screen for compounds that are lethal to S. aureus RN4220Staphylococcus aureus RN4220antiInfectiveantibacterialS. aureuscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted17/04/201717/04/2017Other3279801062
1259309A screen for compounds that are lethal to S. aureus RN4220 with the processive glycosyltransferase UgtP deletedStaphylococcus aureus RN4220antiInfectiveantibacterialS. aureuscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted17/04/201717/04/2017Other3279801782
555Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MKMKmevalonate kinaseStreptococcus PneumoniaeantiInfectiveantibacterialS. PneumoniaeenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted14/12/200609/04/2007Screening65241316
556Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DCMVADdiphosphomevalonate decarboxylaseStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)antiInfectiveantibacterialS. PneumoniaeenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted14/12/200609/04/2007Screening65385320
539Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - PMKMVAK2phosphomevalonate kinaseStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)antiInfectiveantibacterialS. PneumoniaeenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted30/11/200609/04/2007Screening65392319
1662MLPCN Streptokinase Expression InhibitionSKAStreptokinase AStreptococcus pyogenes serotype M1antiInfectiveantibacterialS. PneumoniaeenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted06/04/200909/04/2009Screening3034773959
1863A small molecule screen for inhibitors of the PhoP regulon in Salmonella TyphimuriumPhoB/PhoRPhoP regulonSalmonella TyphiantiInfectiveantibacterialsalmonellosisGFP reportertargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/200922/02/2010Confirmatory300458474
1850A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhiPhoB/PhoRPhoP regulonSalmonella TyphimuriumantiInfectiveantibacterialsalmonellosisGFP reportertargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/07/200917/02/2010Confirmatory3059991018
1159583High throughput screen for small molecule inhibitors of a hypoxia-regulated fluorescent biosensor in Mycobacterium tuberculosisMycobacterium TuberculosisantiInfectiveantibacterialtuberculosisGFP reporterphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted08/01/201617/10/2016Other300060312
449762High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 MediaMycobacterium TuberculosisantiInfectiveantibacterialtuberculosiscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted22/07/201023/07/2010Confirmatory3275581938
540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosisMENB1,4-dihydroxy-2-naphthoyl-CoA synthaseMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)antiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/07/201118/10/2016Other102628440
2221Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing ActivityRECAProtein RecAMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)antiInfectiveantibacterialtuberculosisGFP fluorescencetargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200908/06/2010Screening2933762191
588726Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosisFBAFructose-bisphosphate aldolaseMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)antiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/10/201102/08/2012Screening3592078215
1376Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU)GLMUBifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylaseMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)antiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/08/200828/06/2010Confirmatory215860533
493033A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtIMBTISalicylate synthaseMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)antiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/01/201119/10/2016Other104192927
1949High Throughput Screen of 100,000 compound library to Identify Inhibitors of Mycobacterium tuberculosis H37RvMycobacterium tuberculosis H37RvantiInfectiveantibacterialtuberculosiscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted18/09/200913/10/2009Confirmatory1006851594
1626High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37RvMycobacterium tuberculosis H37RvantiInfectiveantibacterialtuberculosiscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted26/03/200902/10/2009Confirmatory2150982044
434955Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam AntibioticsMycobacterium Tuberculosis sensitization to betaLactamantiInfectiveantibacterialtuberculosiscellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/05/201028/07/2010Confirmatory327901876
488890Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosisMycobacterium tuberculosis, non-replicating, drug-tolerantantiInfectiveantibacterialtuberculosiscellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted25/10/201002/12/2010Confirmatory3244331277
588549Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_ActivityFadD28fatty acyl-AMP ligaseMycobacterium tuberculosisantiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/10/201118/10/2011Screening355054777
602481Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_ActivityBioA7,8-Diaminopelargonic acid synthaseMycobacterium tuberculosisantiInfectiveantibacterialtuberculosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/03/201224/03/2012Screening353572342
1532Rml C and D inhibition 384-well mixture HTSRmlC_inhibitorsantiInfectiveantibacterialtuberculosisenzymeActFlintphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/03/200903/03/2009Screening106271417
504577HTS of Small Molecules that Regulate V-ATPase Proton Transport in Yeast using pHLuorinVMA11V-type proton ATPase subunit c'VMA11antiInfectiveantifungalantifungalpHSensitiveDyetargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/03/201118/01/2012Screening3459851287
1962Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1).TPT1TPT1antiInfectiveantifungalantifungalenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/09/200916/06/2010Screening3026632452
540336Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_ActivityRTT109Histone acetyltransferase RTT109Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)antiInfectiveantifungalcandidiasisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/08/201109/08/2011Screening328088521
1979Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compoundHSP90Heat shock protein 90 homologfluconazole-resistant C.albicansantiInfectiveantifungalcandidiasiscellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/10/200914/10/2009Screening3024511736
485275Phenotypic HTS multiplex for antifungal efflux pump inhibitorsantifungal efflux pumps inhibitorsantiInfectiveantifungalfungsusGeneraltransportFLINTphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/201009/03/2012Screening3288971437
652067Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12)DAF-12Nuclear hormone receptor family member daf-12DAF-12_activatorsantiInfectiveantihelminthicH. contortusexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/02/201325/06/2013Screening3699535353
687014Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12).DAF-12Nuclear hormone receptor family member daf-12DAF-12_activatorsantiInfectiveantihelminthicH. glycinesexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/05/201331/05/2013Screening3699536837
652126Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12)DAF-12Nuclear hormone receptor family member daf-12DAF-12_activatorsantiInfectiveantihelminthicS. stercoralisexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201325/06/2013Screening3699533700
1885Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi ReplicationT. Cruzi replicationantiInfectiveantimicrobialchagascellGrowthphenotypicTID2prospective analytics successfulnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/07/200929/09/2009Screening3032184394
651654HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_ActivityAKadenylate kinaseCryptococcus neoformansantiInfectiveantimicrobialcryptococcosisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/10/201219/10/2012Screening357997735
2451qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia LambliaFBAFructose-bisphosphate aldolaseGiardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)antiInfectiveantimicrobialgiardiasisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/03/201028/04/2010Confirmatory2877382034
540267Small Molecules that selectively kill Giardia lamblia: qHTSGiardia lambliaantiInfectiveantimicrobialgiardiasiscellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/07/201118/07/2011Screening342452530
1721qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK)PYKPyruvate kinaseLeishmania mexicanaantiInfectiveantimicrobialleishmaniasisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/05/200916/03/2010Confirmatory2927321088
1063Leishmania major promastigote HTSLeishmania promastigoteantiInfectiveantimicrobialleishmaniasiscellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/02/200829/02/2008Screening19614117620
1259423Primary cell-based high-throughput screening assay for identification of small molecule agonists of Aedes aegypti NPYLR7 [Small Molecule Inhibitors of Mosquito Biting Behavior]NPYLR7mosquito (Aedes aegypti) neuropeptide receptor NPYLR7 Inhibitors of Mosquito Biting BehaviorantiInfectiveantimicrobialmalariaGFP fluorescencetargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/201820/08/2018Screening265113400
449703NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assayP. Falciparum erythrocyte 3D7antiInfectiveantimicrobialmalariacellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/07/201003/05/2024Confirmatory56084205
2306Inhibition of P. falciparum 3D7P. falciparum 3d7antiInfectiveantimicrobialmalariacellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/01/201013/05/2010Screening1345613456
2302Inhibition of P. falciparum Dd2P. falciparum Dd2antiInfectiveantimicrobialmalariacellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/01/201013/05/2010Screening134567921
449704NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assayP. falciparum erythrocyte W2antiInfectiveantimicrobialmalariacellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/07/201003/05/2024Confirmatory56084612
2304Inhibition of P. falciparum LDHP. falciparum LDHantiInfectiveantimicrobialmalariacellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/01/201013/05/2010Screening134560
1906QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1).CTSL1 Cathepsin L proteinasePFM18AAPinhibitorsCounterscreenantiInfectiveantimicrobialmalariaenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/08/200916/06/2010Screening3026631482
504690uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assayG6PD-6PGLglucose-6-phosphate dehydrogenasePlasmodium bergheiantiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/04/201117/05/2011Screening3489232710
1671177Calibr Malaria Delayed Death Assay SOPPlasmodium falciparumantiInfectiveantimicrobialmalariacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/08/202130/08/2022Confirmatory37708433
1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).Pf-apPOLapicoplast DNA polymerasePlasmodium falciparumantiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/10/202206/10/2022Screening201181519
504832Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubationPlasmodium falciparumantiInfectiveantimicrobialmalariacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/06/201122/06/2011Confirmatory30496918055
504834Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubationPlasmodium falciparumantiInfectiveantimicrobialmalariacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/06/201122/06/2011Confirmatory32320022332
720542qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary ScreenAMA1-RONPlasmodium falciparumantiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/07/201327/07/2013Confirmatory364096735
1347417qHTS Primary assay for Inhibitors of Plasmodium falciparum Dd2 growth in vitroPlasmodium falciparumantiInfectiveantimicrobialmalariacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/04/202006/04/2020Confirmatory1236085316
504621Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2811999Heat shock protein 90, putativePlasmodium falciparum (isolate 3D7)antiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/03/201130/03/2011Screening307132972
504582In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity811941HSP40, subfamily APlasmodium falciparum (isolate 3D7)antiInfectiveantimicrobialmalariasurvivalphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/03/201131/03/2011Screening3365192306
1445Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP)M1AAPAminopeptidase NPlasmodium falciparum (isolate 3D7)antiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/12/200808/12/2008Confirmatory216987913
1619Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)LAPLeucine aminopeptidasePlasmodium falciparum (isolate 3D7)antiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/03/200927/03/2009Confirmatory216988827
1822QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).M18AAPAspartyl aminopeptidasePlasmodium falciparum (isolate 3D7)antiInfectiveantimicrobialmalariaenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/06/200915/06/2010Screening2907263497
1159554Plasmodium falciparum Dd2 Sybr green parasite growth Measured in Cell-Based and Microorganism Combination System Using Plate ReaderPlasmodium falciparum Dd2antiInfectiveantimicrobialmalariacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/09/201522/09/2015Screening930792144
485364qHTS Assay for the Inhibitors of Schistosoma Mansoni PeroxiredoxinsTGRthioredoxin-disulfide reductaseSchistosoma mansoni (Blood fluke)antiInfectiveantimicrobialschistosomiasisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/10/201006/10/2010Confirmatory35664310735
624268Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS)3662741methionine--tRNA ligasemet-tRNA syntantiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/06/201223/07/2012Screening3638031456
624173qHTS of Trypanosoma Brucei InhibitorsTB08.30K1.730Uncharacterized proteinT. bruceiantiInfectiveantimicrobialtrypanosomiasisenzymeActphenotypicTID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted22/05/201230/05/2012Confirmatory406726491
1117264Fluorescence-based biochemical high throughput primary assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1)REL1RNA-editing ligase 1, mitochondrialTrypanosoma brucei bruceiantiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted27/08/201427/08/2014Screening89157438
1430HTS assay for inhibitors of Trypanosoma brucei hexokinase 13663016PhosphotransferaseTrypanosoma brucei brucei (strain 927/4 GUTat10.1)antiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted10/11/200810/11/2008Screening220222239
485367qHTS Assay to Find Inhibitors of T. brucei phosphofructokinaseTB03.3K10.320ATP-dependent 6-phosphofructokinaseTrypanosoma brucei brucei (strain 927/4 GUTat10.1)antiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted06/10/201005/11/2010Confirmatory330677557
624255Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_SinglePoint_HTS_ActivityTrypanosoma cruziantiInfectiveantimicrobialtrypanosomiasiscellDeathGrowthphenotypicTID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted04/06/201204/06/2012Screening765374582
1478qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent)P25779CruzipainTrypanosoma cruziantiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted02/01/200919/02/2010Confirmatory195013848
1476qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent)P25779CruzipainTrypanosoma cruziantiInfectiveantimicrobialtrypanosomiasisenzymeActtargetBasedphenotypeID2prospective analytics successfulcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted02/01/200919/02/2010Confirmatory1950134500
488862Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_ActivityPrP_InhibitorsantiInfectiveantiPrionprionDiseasePrP_reporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/10/201021/10/2010Screening3346341167
1251Anti-Viral Drugs Against Arbovirus Infections, a Primary ScreenBluetongue virus (BTV)antiInfectiveantiviralBTVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/04/200814/04/2008Screening195407715
651958Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substratevOTUviral ovarian tumor domain proteaseCrimean-Congo Hemorrhagic Fever (CCHF) virusantiInfectiveantiviralCCHFVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/12/201226/12/2012Screening3689272045
588689Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme InhibitionP29991Genome polyprotein [Cleaved into: Capsid protein CDengue virus type 2antiInfectiveantiviralDengueenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201126/10/2011Confirmatory3386231013
651640DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_ActivitydengueVirusantiInfectiveantiviralDenguecellViabilityphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201212/10/2012Screening3433055946
2234Counterscreen for inhibitors of EBNA-1: fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of the Epstein-Barr virus-encoded protein, ZTA.P03206Lytic switch protein BZLF1Epstein-Barr virusantiInfectiveantiviralEBVcounterScreentargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/01/201015/06/2010Screening314999485
1950Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1).BKRF1BKRF1 protein, Epstein-Barr nuclear antigen 1Epstein-Barr virusantiInfectiveantiviralEBVFP-DNA-bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/09/200916/06/2010Screening3026631022
504558Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_ActivityLMP1Latent membrane protein 1Epstein-Barr virusantiInfectiveantiviralEBVInfectionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/03/201124/03/2011Screening3450642373
1085uHTS for Small Molecule Inhibitiors of Epstein-Barr Virus InhibitorsQ1HVG2Glycoprotein 42Epstein-Barr virusantiInfectiveantiviralEBVFP_bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/03/200803/03/2008Screening218602926
1159524High Throughput Screening for Foot and Mouth Disease Virus AntiviralsFoot-and-mouth disease virusantiInfectiveantiviralFMDVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/07/201515/07/2015Confirmatory4040625020
1745856Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Firefly Luciferase SignalP03308Genome polyprotein [Cleaved into: Leader proteaseFoot-and-mouth disease virusantiInfectiveantiviralFMDVcellDeathGrowthtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/06/202216/06/2022Confirmatory117258273
1745857Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Renilla Luciferase SignalP03308Genome polyprotein [Cleaved into: Leader proteaseFoot-and-mouth disease virusantiInfectiveantiviralFMDVcellDeathGrowthtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/06/202216/06/2022Confirmatory117258373
1347131qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound libraryAAA42670Genome polyprotein [Cleaved into: Leader proteaseFoot-and-mouth disease virusantiInfectiveantiviralFMDVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/09/201912/09/2019Confirmatory4040631959
504329Discovery of Small Molecule Probes for H1N1 Influenza NS1ANS1Non-structural protein 1Influenza A virusantiInfectiveantiviralH1N1alphaScreentargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201122/02/2011Confirmatory3352241010
2326qHTS Assay for Inhibitors of Influenza NS1 Protein FunctionNS1Non-structural protein 1Influenza NS1antiInfectiveantiviralH1N1enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/02/201001/02/2010Confirmatory2695611073
1259415qHTS Assay for inhibitors of the human cytomegalovirus (HCMV)HCMV inhibitorsantiInfectiveantiviralHCMVInfectionReporterphenotypicTID0under evaluationnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/06/201820/06/2018Screening40325618370
1918969Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear EgressNEC2Nuclear egress membrane protein, Nuclear egress protein 2Human cytomegalovirusantiInfectiveantiviralHCMVFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/08/202302/11/2023Screening183911278
651820qHTS Assay for Inhibitors of Hepatitis C Virus (HCV)HCV inhibitorsantiInfectiveantiviralHCVInfectionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/11/201228/11/2012Confirmatory33957311624
1845Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID)NS3Genome polyproteinHepacivirus hominisantiInfectiveantiviralHCVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/07/200915/06/2010Screening290725487
1800Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3)NS3Genome polyproteinHepacivirus hominisantiInfectiveantiviralHCVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/06/200915/06/2010Screening2907261635
1899TR-FRET-based primary biochemical high-throughput screening assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerizationABC47431Core proteinHepacivirus hominisantiInfectiveantiviralHCVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/08/200915/06/2010Screening302663998
623901Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_ActivitymiR122_inhibitorsantiInfectiveantiviralHCVexprressionReporterLuciphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/03/201228/03/2012Screening333274472
504423C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_ActivityORF73LANAHuman herpesvirus 8antiInfectiveantiviralHHV-8FP_bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/03/201107/03/2011Screening336515262
2629Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B InteractionLANA1Protein LANA1Human herpesvirus 8antiInfectiveantiviralHHV-8enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/03/201022/03/2010Screening3235641946
493011uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assayAPOBEC3ADNA dC->dU-editing enzyme APOBEC-3AAPOBEC3A_inhibitorsantiInfectiveantiviralHIVenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/01/201105/01/2011Screening3317531372
602313qHTS for Inhibitors of Vif-A3F Interactions: qHTSAPOBEC3FDNA dC->dU-editing enzyme APOBEC-3FAPOBEC3F_inhibitorsantiInfectiveantiviralHIVPPI_FLINTtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/03/201208/03/2012Confirmatory383848765
602310qHTS for Inhibitors of Vif-A3G Interactions: qHTSAPOBEC3GDNA dC->dU-editing enzyme APOBEC-3GAPOBEC3G_inhibitorsantiInfectiveantiviralHIVPPI_FLINTtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/03/201227/11/2012Confirmatory402348311
493012uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assayAPOBEC3GDNA dC->dU-editing enzyme APOBEC-3GAPOBEC3G_inhibitorsantiInfectiveantiviralHIVenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/01/201105/01/2011Screening331753931
651610HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_ActivityHIV fussionantiInfectiveantiviralHIVcellFussionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/10/201224/10/2012Screening3548223866
463187384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSCHck-NefHck-NefHIV type 1antiInfectiveantiviralHIVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/09/201001/09/2010Screening2202221495
372HIV-1 RNase H InhibitionGAG-POLGag-Pol polyproteinHIV type 1antiInfectiveantiviralHIVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/03/200622/08/2008Screening99768769
565HIV-1 RT-RNase H MLSCN HTS MH077605GAG-POLGag-Pol polyproteinHIV type 1antiInfectiveantiviralHIVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200626/09/2007Screening652181250
1259389HIV1_TAR : FRET assay measuring displacement of FAM and TAMRA-labeled Tat peptide from HIV-1 TAR RNA.TARtransactivation response elementHIV type 1antiInfectiveantiviralHIVFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/03/201809/03/2018Screening103073615
602346Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_ActivityVIFVirion infectivity factorHIV type 1antiInfectiveantiviralHIVFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/03/201209/03/2012Screening3356811162
179NCI AIDS Antiviral AssayHIV type 1antiInfectiveantiviralHIVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004Confirmatory419761527
704Primary biochemical high-throughput screening assay for inhibitors of the HIV Rev RRE RNA interaction (disruption of protein-RNA interaction)REVProtein RevHIV type 1antiInfectiveantiviralHIVFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/05/200706/11/2009Screening96879769
624416TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9ENVEnvelope glycoprotein gp160HIV type 1antiInfectiveantiviralHIVTRFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/07/201226/07/2012Screening3625771546
1986uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors.ENVEnvelope glycoprotein gp160 [Cleaved into: Surface protein gp120HIV type 1antiInfectiveantiviralHIVviralFusiontargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/10/200930/12/2010Confirmatory292323890
1117319High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interactionVIFVirion infectivity factorHIV-VIFantiInfectiveantiviralHIVFRET bindingtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/02/201523/03/2015Confirmatory2587501498
651644qHTS Assay for Inhibitors of the HIV-1 protein VprVPRProtein VprHIV-VPRantiInfectiveantiviralHIVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/10/201216/10/2012Confirmatory361879750
743269TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA IntegrationPSIP1PC4 and SFRS1-interacting proteinPSIP1antiInfectiveantiviralHIVFRET bindingtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/01/201431/01/2014Screening3699532353
540256qHTS for Inhibitors of binding or entry into cells for Lassa VirusLassa virus entryantiInfectiveantiviralLassa virusviralEntryphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/07/201123/07/2011Confirmatory2971563648
540276qHTS for inhibitors of binding or entry into cells for Marburg VirusMargburg virus entryantiInfectiveantiviralMargburg virusviralEntryphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/07/201118/11/2011Confirmatory2841604700
841Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library)RNA-Dependent RNA Polymerase ComplexMeasles VirusantiInfectiveantiviralMeaslescellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/11/200706/11/2007Screening1377772077
588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activitiesP03300Genome polyprotein [Cleaved into: P1; Capsid protein VP0Poliovirus type 1antiInfectiveantiviralPoliovirus type 1enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/10/201118/10/2016Other1515251001
2391A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV)Respiratory syncytial virusantiInfectiveantiviralRSVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201022/02/2010Confirmatory313719409
PLP&3CLP proteasesPChem screens plus phenotypic records @ ChEMBLPLP&3CLP proteasesPLP&3CLP proteasesSARS-CoVantiInfectiveantiviralSARS-CoVproteases& cellDeathphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletedcompleted
1706QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)AAZ820163C-like proteaseSARS-CoVantiInfectiveantiviralSARS-CoVenzymeActtargetBasedphenotypeID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted01/05/200915/06/2010Screening290726405
485353qHTS of Yeast-based Assay for SARS-CoV PLPREPReplicase polyprotein 1abSARS-CoVantiInfectiveantiviralSARS-CoVenzymeActtargetBasedphenotypeID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted05/10/201012/11/2010Confirmatory328641609
1903Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagentsP03070Large T antigenSimian virus 40 (SV40)antiInfectiveantiviralSV40enzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/08/200904/03/2011Confirmatory3053551203
493162A screen for compounds that inhibit processive DNA synthesis of vaccinia virusOPG071DNA polymeraseVaccinia virus (VACV)antiInfectiveantiviralVACVenzymeActtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/02/201119/10/2016Other45651427
720579qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS3707576Ankyrin repeat protein B19Vaccinia virus (VACV)antiInfectiveantiviralVACVInfectionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/08/201321/08/2013Confirmatory3067371931
720580qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS3707576Ankyrin repeat protein B19Vaccinia virus (VACV)antiInfectiveantiviralVACVInfectionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/08/201319/08/2013Confirmatory3263631520
588727A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83Venezuelan equine encephalitis virusantiInfectiveantiviralVEEVcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/10/201130/10/2011Confirmatory347901453
720596TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC)PRNPMajor prion proteinPRNPantiInfectiveprionDiseaseprionDiseaseexpressiontargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/09/201303/09/2013Screening3699531596
686954uHTS identification of small molecule inhibitors of Artemis endonuclease activity via a fluorescence intensity assayDCLRE1CProtein artemisartemis_inhibitorscancercanceracuteLymphoblasticLymphomaenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/04/201325/04/2013Screening30104235
8 cell line screens at ChEMBLBrCa cell linescancercancerbreast cancercellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedunderwaynotStartednotStartednotStartednotStartednotStartednotStarted
avg of cell line screens at ChEMBLBrCaAvgcancercancerbreast cancercellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletedcompleted
720582QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10.ADAM10Disintegrin and metalloproteinase domain-containing protein 10ADAM10_inhibitorscancercancerbreastCancerenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/08/201321/08/2013Screening3699532294
720648QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17.ADAM17Disintegrin and metalloproteinase domain-containing protein 17ADAM17_inhibitorscancercancerbreastCancerenzymeActFlinttargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/10/201317/10/2013Screening3699533080
624202qHTS Assay to Identify Small Molecule Activators of BRCA1 ExpressionBRCA1Breast cancer type 1 susceptibility proteinBRCA1 activationcancercancerbreastCancerexpressionReporterphenotypic&targetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/05/201224/05/2012Confirmatory3760293978
89NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200411/04/2024Confirmatory372322330
1794793NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening716552694
97NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200412/04/2024Confirmatory385022659
1794788NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening718412560
83NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200411/04/2024Confirmatory404004425
1794796NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening759814212
95NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200414/04/2024Confirmatory400902464
1794789NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening747063330
85NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200411/04/2024Confirmatory401933548
1794794NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening750715500
93NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200412/04/2024Confirmatory407792492
1794790NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening749722944
91NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartedcompleted15/08/200412/04/2024Confirmatory381482490
1794792NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell linebreastCancercancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening727673276
2717Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem CellsbreastCancerStemCellsCadherinNullcancercancerbreastCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/03/201001/03/2011Screening3006213187
629HTS of Estrogen Receptor- alpha Coactivator Binding inhibitorsESR1Estrogen receptor, Estrogen receptorESR1_inhibitorscancercancerbreastCancerPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/03/200723/04/2007Screening860951442
633HTS for Estrogen Receptor-beta Coactivator Binding inhibitorsESR2Estrogen receptor betaESR2_inhibitorscancercancerbreastCancerPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/03/200704/06/2007Screening860951114
485317HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSGFERFAD-linked sulfhydryl oxidase ALRALR inhibitorscancercancercancerenzymeActtargetBasedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablecompletedstartednotStarted29/09/201018/10/2010Screening28872810857
595qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction Disrupters of an Hsp90 Co-Chaperone InteractioncancercancercancerGeneralPPI_alphascreenphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/02/200719/10/2007Confirmatory69668300
1259310AlphaScreen-based biochemical high throughput primary assay to identify activators of the E3 ligase (FBW7).FBW7 E3 ligase E3 ligase activatorscancercancercancerGeneralPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/04/201717/04/2017Screening641445853
651550HTS Assay for Inhibitors of Akt Phophorylation: Primary ScreenAKT1RAC-alpha serine/threonine-protein kinaseAKT1_inhibitorscancercancercancerGeneralenzymeActPhosphorylationtargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/08/201224/08/2012Screening3565171139
1671190Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12ALOX12_inhibitorscancercancercancerGeneralenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/08/202118/08/2021Confirmatory5642886030
881qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2)ALOX15BPolyunsaturated fatty acid lipoxygenase ALOX15BALOX15B_inhibitorscancercancercancerGeneralenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/12/200704/03/2011Confirmatory107252595
489031uHTS Fluorescent assay for identification of activators of Apaf-1APAF1Apoptotic protease-activating factor 1APAF1_activatorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/11/201014/04/2011Screening3316711041
2517qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)APEX1DNA repair nuclease/redox regulator APEX1APEX1_inhibitorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/03/201016/07/2013Confirmatory3458981172
2521uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assayAPLNRApelin receptorAPLNR_antagonistscancercancercancerGeneralbetaArrestintargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/03/201013/01/2011Screening3303921062
504490Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction That Mediate GPCR Degradation and RecyclingARRB1Beta-arrestin-1 , cDNA FLJ53544ARRB1_inhibitorscancercancercancerGeneralPPI_FLINTtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/201126/03/2011Screening3383731061
504466qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1ATAD5ATPase family AAA domain-containing protein 5ATAD5_inhibitorscancercancercancerGeneralreporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/201116/03/2011Confirmatory3301094174
504467qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1ATAD5ATPase family AAA domain-containing protein 5ATAD5_inhibitorscancercancercancerGeneralreporterLucitargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartedunderway16/03/201116/03/2011Confirmatory3301077652
436HTS for BAP1 Enzyme inhibitorsBAP1Ubiquitin carboxyl-terminal hydrolase BAP1BAP1_inhibitorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/06/200603/01/2008Screening71016346
2528qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)BLMRecQ-like DNA helicase BLMBLM_inhibitorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/03/201015/03/2010Confirmatory347933673
1224903Identification of CBX7 inhibitors - Primary Alpha ScreenCBX7Chromobox protein homolog 7 inhibitorsChromobox protein homolog 7 inhibitorscancercancercancerGeneralPPI_alphascreentargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/10/201624/10/2016Screening64999724
1347074Dicer-mediated maturation of pre-microRNADICER1DicerDicer_inhibitorscancercancercancerGeneralenzimeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/07/201929/07/2019Other467152829
504332qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9aEHMT2E92 histone-lys N-methyltransferase 2EHMT2_inhibitorscancercancercancerGeneralalphaScreenMethylationtargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201122/02/2011Confirmatory34833830875
651548EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_ActivityEZH2Histone-lysine N-methyltransferase EZH2EZH2_inhibitorscancercancercancerGeneralenzymeActTRFtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/08/201223/08/2012Screening57013201
602261uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assayFASNFatty acid synthaseFASN_inhibitorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/02/201216/02/2012Screening3620632427
645Isolation of Inhibitors of Her-Kinase Expression - 66K library screenHer-Kinase ExpressioncancercancercancerGeneralproteinExpressionAlphascreenphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/04/200716/11/2007Screening64629448
624352uHTS identification of HIF-2a Inhibitors in a luminesence assayEPAS1Endothelial PAS domain-containing protein 1HIF-2a_inhibitorscancercancercancerGeneralexpressionReporterLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/07/201203/07/2012Screening3638402624
429HTS for Tumor Hsp90 InhibitorsHSP90AA1Heat shock protein HSP 90-alphaHSP90 known inhibitor displacementcancercancercancerGeneralbindingtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/06/200618/10/2007Screening63696220
1259370Inhibitors of CDC25B-CDK2/CyclinA interactionCCNA2Cyclin-A2Inhibitors of CDC25B-CDK2/CyclinA interactioncancercancercancerGeneralPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/02/201823/02/2018Other93798679
1347041qHTS assay for inhibitors of human lactate dehydrogenaseLDHA lactate dehydrogenaselactateDehydrogenaseInhibitorscancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/04/201917/04/2019Screening476056732
1347076qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1ABCB1ATP-binding cassette, sub-family B , ATP-dependent translocase ABCB1MDR1-selective compoundscancercancercancerGeneralcellDeathGrowthtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/07/201931/07/2019Confirmatory39602913426
1347075qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1ABCB1ATP-binding cassette, sub-family B , ATP-dependent translocase ABCB1MDR1-selective compoundscancercancercancerGeneralcellDeathGrowthtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/07/201931/07/2019Confirmatory3959815516
2289qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21miRNA_modulatorscancercancercancerGeneralmiRNA_stainFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/01/201025/01/2010Confirmatory3335103282
2029Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN.CIT2Citrate synthase, peroxisomalmTOR_pathwayModulatorscancercancercancerGeneralreporterGFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/200905/04/2011Screening321534210
2023Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN.APE1Vacuolar aminopeptidase 1mTOR_pathwayModulatorscancercancercancerGeneralreporterGFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/200905/04/2011Screening3247341090
588692Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2NLG_inhibitorscancercancercancerGeneralNLG_reporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201128/11/2011Screening358025830
504444Nrf2 qHTS screen for inhibitorsNFE2L2Nuclear factor erythroid 2-related factor 2nrf2InhibitorscancercancercancerGeneralexpressionReportertargetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaynotStarted15/03/201115/03/2011Confirmatory3608737438
449763uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assayPERK-elF2a-CHOP pathway activatorscancercancercancerGeneralexprressionReporterLuciphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/07/201014/01/2011Screening3316711124
588405HTS Assay for Peg3 Promoter InhibitorsPPP1R15AProtein phosphatase 1 regulatory subunit 15APPP1R15AcancercancercancerGeneralexpressionReportertargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/09/201123/09/2011Screening3592446145
1347419Antagonist identification of Pyk2 oligomerization: high-throughput screening cellular assayPTK2BProtein tyrosine kinase 2 betaPyk2 cancercancercancerGeneraloligomerizationLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/04/202022/04/2020Other98749818
868Screen for Chemicals that Inhibit the RAM NetworkRAM network inhibitorscancercancercancerGeneralyeastGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/12/200703/06/2008Screening1945503545
1159607Screen for inhibitors of RMI FANCM (MM2) intereactionRMI FANCM intereactioncancercancercancerGeneralPPI_FPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/02/201618/04/2016Other69794402
624156Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_ActivityrosLevelscancercancercancerGeneralrosLevelsFlintphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/05/201216/05/2012Screening45939901
1347056Inhibitor identification of TROY dependent signaling using uHTS single point assayTROY_signalling_inhibitorscancercancercancerGeneralnfkbReporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/06/201904/06/2019Screening3606573551
1259251AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of Unc-51 Like Autophagy Activating Kinase 1 (ULK1).ULK1Unc-51 Like Autophagy Activating Kinase 1ULK1cancercancercancerGeneralenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/03/201706/03/2017Screening30185575
1992HTS Colorimetric assay for the identification of compounds that inhibit VHR1DUSP3Dual specificity protein phosphatase 3VHR1_inhibitorscancercancercancerGeneralenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/10/200930/12/2010Screening49813347
1654uHTS absorbance assay for the identification of compounds that inhibit VHR1.DUSP3Dual specificity protein phosphatase 3VHR1_inhibitorscancercancercancerGeneralenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/04/200930/12/2010Confirmatory2910061524
2012uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)EIF4HEukaryotic translation initiation factor 4HEIF4HcancercancercancerGeneralbindingFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/10/200912/01/2011Confirmatory2909152744
588458uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assayDNMT1DNA methyltransferase-1DNMT1cancercancercancerGeneralenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/10/201106/10/2011Screening3592442975
1789Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90)HSP90AA1Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens , Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-alphaHSP90AA1cancercancercancerGeneralenzymeActtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/05/200915/06/2010Screening2907262649
504706qHTS assay for re-activators of p53 using a Luc reporterTP53Cellular tumor antigen p53, Cellular tumor antigen p53TP53cancercancercancerGeneralexpressionReporterphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted27/04/201127/04/2011Confirmatory321427201
1259400qHTS Assay for Antagonists of the Relaxin Receptor RXFP1RXFP1Relaxin receptor 1relaxinInhibitorscancercancercancerGeneralcAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/03/201820/03/2018Screening3501772058
167NCI Yeast Anticancer Drug Screen. Data for the bub3 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004805049618
165NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004804988083
157NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004811338837
175NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/20048111210175
155NCI Yeast Anticancer Drug Screen. Data for the rad50 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004811339814
161NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strainyeastScreenWithAlterationsInDnaRepaircancercancercancerWithAlterationsInDnaRepaircellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004804989555
45NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory529312856
1794759NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening752892115
47NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory532053526
1794758NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening723533611
49NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory505113547
1794752NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening745204513
53NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory527782515
1794751NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening742081576
55NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200414/04/2024Confirmatory496853444
1794750NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening730933359
59NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell lineCNS_tumorcancercancerCNS_tumorcellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory532113544
9 cell line screens at ChEMBLCoCa cell linescancercancercolon cancercellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedunderwayunderwayunderwayunderway
67NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory527123480
1794742NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening727434943
77NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory484212752
1794799NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening728523007
79NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory527274422
1794798NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening755515013
71NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory530503475
1794746NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening755303437
65NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory528443773
1794748NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202215/04/2024Screening746885101
73NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory531043462
1794800NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening752183369
81NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200411/04/2024Confirmatory535084024
1794795NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell linecolonCancercancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening753273576
818High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin ExpressioncolonCancerNotExpressingOncogenicBetaCatenincancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/10/200716/10/2007Screening1387372051
827High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor SuppressorcolonCancerwithPtenDeletioncancercancercolonCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/10/200716/10/2007Screening1384171658
651661Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity EWS/Fli transcriptional activity inhibitorscancercancerEwingSarcomacellViabilityAlamarBluephenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/10/201226/10/2012Screening3422362318
1794753NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell lineglioblastomacancercancerglioblastomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening731843470
1159606uHTS identification of small molecule inhibitors of TWEAK-Fn14 interactions, using a cell-based reporter assayinhibitors of TWEAK-Fn14 interactionscancercancerglioblastomareporterLumiGlophenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/02/201624/02/2016Other3620637302
686971qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell linegliomaWithIdh1MutationscancercancergliomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/05/201309/05/2013Confirmatory3644647438
686970qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell lineHEL-S-26Isocitrate dehydrogenase [NADP]gliomaWithIdh1MutationscancercancergliomacellDeathGrowthtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/05/201309/05/2013Confirmatory3644645966
602342Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_ActivitymiR122_activatorscancercancerhepatocellularCarcinomaexprressionReporterLuciphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/03/201216/03/2012Screening3332741022
588664TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl)ABL1Tyrosine-protein kinase ABL1ABL1_interactioncancercancerleukemiaPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/10/201125/10/2011Screening3592071432
624256HTS to identify compounds that promote myeloid differentiation with MLPCN compound setHOXA9Homeobox protein Hox-A9HOXA9cancercancerleukemiaexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/06/201218/06/2012Screening3585563721
119NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory505805047
1794778NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening704894627
1794776NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening716755995
121NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory518554709
1794777NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening718804980
123NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory522194310
1794779NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening737774676
113NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory497814206
1794781NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening707804886
115NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory443075398
1794780NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell lineleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening671135428
248NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) miceleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004557411560
330NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) miceleukemiacancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200415/08/2004445272353
1768qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant PeptideMEN1MeninMenin-MLL_inhibitorscancercancerleukemiaPPItargetBasedassayID2prospective analytics successfulcompletedcompletedcompletednotStartednotStartednotStartednotStartednotStarted15/05/200915/05/2009Confirmatory263421615
125NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell linerenalCancercancercancerleukemiacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory484264751
11 cell line screens at ChEMBLLuCa cell linescancercancerlung cancercellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway
23NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200410/04/2024Confirmatory500803993
1794757NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening734624776
25NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200410/04/2024Confirmatory522573432
1794745NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening739684221
29NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200410/04/2024Confirmatory494162812
1794766NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening718823760
35NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory502952412
1794763NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening709392926
39NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200410/04/2024Confirmatory525931983
1794761NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202215/04/2024Screening748692694
37NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory524383585
1794755NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening733274240
33NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory527172210
1794764NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening717972912
31NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory523993598
1794756NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell linemelanomacancercancermelanomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening747823675
1259374AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of microphthalmia-associated transcription factor (MITF)MITFcDNA FLJ53142, highly similar to Microphthalmia-associated transcription factor, Melanocyte inducing transcription factor, Microphthalmia-associated transcription factor , Microphthalmia-associated transcription factor isoformMITF inhibitorscancercancermelanomaalphaScreentargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/02/201820/02/2018Screening6423625830
588334MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_ActivityMITF_expressionEnhancerscancercancermelanomaexpressionReporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/08/201125/08/2011Screening3008452272
493098uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assayCCR6C-C chemokine receptor type 6CCR6_antagonistscancercancermetastasisbetaArrestinLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/01/201127/01/2011Screening3406961654
602244uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assayCXCR6C-X-C chemokine receptor type 6CXCR6_inhibitorscancercancermetastasisbetaArrestinLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/02/201213/03/2012Screening3620631298
652025qHTS of IL-2 ActivatorsIL2Interleukin-2IL2cancercancerneoplasm of thoraxtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/02/201312/02/2013Confirmatory364617238
743126QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)PLA2G3Group 3 secretory phospholipase A2PLA2G3cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/11/201325/11/2013Screening3699532089
651658Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_ActivityFGF22Fibroblast growth factor 22FGF22_inhibitorscancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/10/201219/10/2012Screening3396505128
803Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2)GALR2Galanin receptor type 2GALR2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/09/200716/06/2010Screening140088678
828Primary cell-based high-throughput screening assay to identify antagonists of Galanin Receptor 2 (GALR2)GALR2Galanin receptor type 2GALR2_antagonistscancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/10/200716/06/2010Screening140088548
1346428qHTS for Agonists of Human Resolvin D1 Receptor DRV1GPR32Probable G-protein coupled receptor 32GPR32cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/11/201826/11/2018Screening474731217
2013Image-Based HTS for Selective Antagonists for GPR55GPR55G-protein coupled receptor 55GPR55cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/10/200912/01/2011Confirmatory291657370
2718Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3HDAC3Histone deacetylase 3HDAC3cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/03/201029/03/2010Screening318291483
759HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtypeHRASGTPase HRasHRAScancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/07/200726/10/2009Screening194628267
2098Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1).HSF1Heat shock factor 1 , Heat shock factor protein 1 , Heat shock transcription factor 1 alpha isoform, Heat shock transcription factor 1 beta isoform, Heat shock transcription factor 1 gammaalpha isoformHSF1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/11/200904/11/2009Screening3013242328
1446Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617FJAK2Tyrosine-protein kinase , Tyrosine-protein kinase JAK2JAK2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/12/200816/06/2010Screening2179592390
504327qHTS Assay for Inhibitors of GCN5L2KAT2AHistone acetyltransferase KAT2AKAT2Acancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201122/02/2011Confirmatory381571792
2147qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E)KDM4ELysine-specific demethylase 4EKDM4Ecancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/11/200919/11/2009Confirmatory2269143523
504523Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_ActivityKEAP1Kelch-like ECH-associated protein 1KEAP1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/201121/03/2011Screening336894489
1700Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5)KLF5Epididymis secretory sperm binding protein , Krueppel-like factor 5KLF5cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/04/200929/06/2009Screening290726671
873Kallikrein 5 1536 HTSKLK5Kallikrein-5KLK5cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/12/200719/11/2008Screening2141871264
652039Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogenKLK7Kallikrein-7KLK7cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/02/201314/02/2013Screening3689273325
485360qHTS Assay for the Inhibitors of L3MBTL1L3MBTL1LethalL3MBTL1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/10/201005/10/2010Confirmatory2253091492
2174Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1).LYPLA1Acyl-protein thioesterase 1LYPLA1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/12/200915/06/2010Screening314999499
1529Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 WildtypeMAP3K3Mitogen-activated protein kinase kinase kinase 3MAP3K3cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/03/200902/03/2009Screening2895734159
995qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening AssayMAPK1Mitogen-activated protein kinase 1MAPK1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/12/200706/07/2010Confirmatory70898707
1454qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGFMAPK1Mitogen-activated protein kinase 1MAPK1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/12/200819/12/2008Confirmatory131324544
746Primary biochemical high-throughput screening assay for inhibitors of the c-Jun N-Terminal Kinase 3 (JNK3)MAPK10Mitogen-activated protein kinase 10MAPK10cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/06/200725/06/2007Screening59788366
1230E3 Ligase HTS_1536MDM2E3 ubiquitin-protein ligase Mdm2MDM2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/03/200818/03/2009Screening207811220
485346uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format.MDM4Protein Mdm4MDM4cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201004/10/2010Screening33167110022
488899MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_ActivityMITFcDNA FLJ53142, highly similar to Microphthalmia-associated transcription factor, Melanocyte inducing transcription factor, Microphthalmia-associated transcription factor , Microphthalmia-associated transcription factor isoformMITFcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201025/10/2010Screening3313602760
651704Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_ActivityMLLT3Protein AF-9MLLT3cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201221/02/2013Screening3444591627
588354Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1)NCOA1Nuclear receptor coactivator 1NCOA1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/09/201113/09/2011Screening359206428
651957Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2)NCOA2Nuclear receptor coactivator 2NCOA2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/12/201226/12/2012Screening368927620
793Primary cell based high-throughput screening assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2)NPY2RNeuropeptide Y receptor type 2NPY2Rcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/08/200716/06/2010Screening1400881384
1359Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2NPY2RNeuropeptide Y receptor type 2NPY2Rcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/200815/06/2010Screening217959969
602396Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2)NR5A2Nuclear receptor subfamily 5 group A member 2NR5A2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201221/09/2012Screening363803458
743445Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2NSD2Histone-lysine N-methyltransferase NSD2NSD2cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/04/201410/04/2014Screening3096841662
493036Image-Based HTS for Selective Agonists for NTR1NTSR1Neurotensin receptor type 1NTSR1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/01/201131/03/2011Screening331753556
1778uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assayOPRK1Kappa-type opioid receptorOPRK1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/200930/12/2010Confirmatory290355265
504326Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptorsOPRM1Mu-type opioid receptorOPRM1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201126/09/2011Screening335239991
504357Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptorsOPRM1Mu-type opioid receptorOPRM1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/02/201124/02/2011Screening335239695
2014uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)PABPC1Polyadenylate-binding protein 1PABPC1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/10/200912/01/2011Confirmatory2909152982
588489uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assayPABPC1Polyadenylate-binding protein 1PABPC1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/10/201111/10/2011Screening3592441307
588579qHTS for Inhibitors of Polymerase KappaPOLKDNA polymerase kappaPOLKcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/10/201120/10/2011Confirmatory3952952034
504707Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complexPRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]PRKAR1Acancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/04/201127/04/2011Screening343468285
764HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutantRAC1Ras-related C3 botulinum toxin substrate 1RAC1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/07/200725/10/2009Screening194629219
757HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtypeRAC1Ras-related C3 botulinum toxin substrate 1RAC1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/07/200726/10/2009Screening194628521
602329Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_ActivityRAD54LDNA repair and recombination protein RAD54-likeRAD54Lcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/03/201208/03/2012Screening358498505
1347404ROC1-CUL1 CTD Inhibitor di-Ub FRET Primary HTS ScreenRBX1E3 ubiquitin-protein ligase RBX1RBX1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/03/202013/03/2020Screening143816859
2563Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting EnzymeRCE1CAAX prenyl protease 2RCE1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/201016/03/2010Screening294698799
2549qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)RECQLATP-dependent DNA helicase Q1RECQLcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201015/03/2010Confirmatory2349151245
1496uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb via a fluorescence resonance energy transfer (FRET) assay.RUNX1Runt-related transcription factor 1RUNX1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/01/200929/12/2010Screening215667993
1434uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay.RUNX1Runt-related transcription factor 1RUNX1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/11/200819/01/2011Confirmatory2182341620
686992Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_ActivitySELEE-selectinSELEcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/05/201321/10/2013Screening257988963
2540HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8)SENP8Sentrin-specific protease 8SENP8cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/03/201013/01/2011Screening3303924119
602440uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8)SENP8Sentrin-specific protease 8SENP8cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/201221/03/2012Screening3638402341
602393Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_ActivitySMARCA4Transcription activator BRG1SMARCA4cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201214/03/2012Screening3447337043
623870ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_ActivityTACC3Transforming acidic coiled-coil-containing protein 3TACC3cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/03/201227/03/2012Screening3911792589
624354uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assayTNFRSF10BTumor necrosis factor receptor superfamily member 10BTNFRSF10Bcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/07/201203/07/2012Screening3638403764
588453qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTSTXNRD1Thioredoxin reductase 1, cytoplasmicTXNRD1cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/10/201105/10/2011Confirmatory3866633977
651699uHTS identification of inhibitors of cullin neddylation in a TR-FRET assayUBE2MNEDD8-conjugating enzyme Ubc12UBE2Mcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201225/10/2012Screening3638402123
1645853USP8 deubiquitinase inhibition: Primary qHTSUSP8Ubiquitin carboxyl-terminal hydrolase 8USP8cancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other474802010
651768qHTS for Inhibitors of WRN HelicaseWRNBifunctional 3'-5' exonuclease/ATP-dependent helicase WRNWRNcancercancerneoplastic disease or syndrometargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/11/201216/11/2012Confirmatory3640111678
19NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory535602992
1794740NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202215/04/2024Screening743862485
21NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory508202137
1794765NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening643891626
9NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory520012981
1794735NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202215/04/2024Screening736432556
13NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory475373298
1794738NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202214/04/2024Screening651893616
3NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory495642467
1794732NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202215/04/2024Screening723752184
1NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory532143094
1794731NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/09/202215/04/2024Screening750102580
5NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory520462317
1794733NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202218/04/2024Screening730501747
7NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory520334098
1794736NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202214/04/2024Screening752114608
15NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell linenonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedunderwayunderwayunderwaynotStartednotStarted15/08/200410/04/2024Confirmatory489874260
1794739NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomacancercancernonSmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/09/202212/04/2024Screening712755229
904qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive TemperatureTP53Cellular tumor antigen p53nonSmallCellLungCarcinomaWithP53MutationscancercancernonSmallCellLungCarcinomacellDeathGrowthtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200706/07/2010Confirmatory54509528
903qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive TemperatureTP53Cellular tumor antigen p53nonSmallCellLungCarcinomaWithP53MutationscancercancernonSmallCellLungCarcinomacellDeathGrowthtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200706/07/2010Confirmatory54513338
902qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive TemperatureTP53Cellular tumor antigen p53nonSmallCellLungCarcinomaWithP53MutationscancercancernonSmallCellLungCarcinomacellDeathGrowthtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200706/07/2010Confirmatory1253941890
924qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive TemperatureTP53Cellular tumor antigen p53nonSmallCellLungCarcinomaWithP53MutationscancercancernonSmallCellLungCarcinomacellDeathGrowthtargetBasedTID-assayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200706/07/2010Confirmatory1240221156
1794786NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening728673166
101NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory526093249
1794787NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening748644915
99NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory519833749
1794784NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening730882443
105NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory509692336
1794783NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening750041854
107NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory525022104
1794782NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening745862891
109NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory534263114
1794785NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening732972087
103NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell lineovarianCancercancercancerovarianCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory510812532
1794760NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell lineprostateCancercancercancerprostateCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202216/04/2024Screening747762861
43NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell lineprostateCancercancercancerprostateCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory405982824
1794754NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell lineprostateCancercancercancerprostateCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/202214/04/2024Screening737002603
41NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell lineprostateCancercancercancerprostateCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200411/04/2024Confirmatory404983034
686964TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotideMBD2Methyl-CpG-binding domain protein 2MBD2cancercancerReactivate the silenced genes in cancer cellsFRET bindingtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/05/201301/05/2013Screening3699531149
1794775NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202215/04/2024Screening746883319
137NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory524283081
1794774NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening698513516
129NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory470903449
1794771NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening745453244
139NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory528943233
1794772NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening683222874
131NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory501883283
1794773NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening712154339
133NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory480613402
1794767NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening747082495
145NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory529673005
1794769NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202214/04/2024Screening744452716
141NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory520471986
1794768NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/202216/04/2024Screening746773544
143NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell linerenalCancercancercancerrenalCancercellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/08/200412/04/2024Confirmatory527262935
598Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K ScreensmallCellLungCarcinomaCellLineExpressingTransportDetoxProtMDR1cancercancersmallCellLungCarcinomacellDeathGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/02/200716/11/2007Screening852005142
2690A yeast HTS for caloric restriction mimetics that inhibit age-related superoxidesuperoxideGenerationInhibitorsnonProligerativebiologicalProcessagingsuperoxideFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/03/201019/05/2010Screening328830590
648Human Endothelial Cell Proliferation Assay in 384-well formatangiogenesis_modulatorsnonProligerativebiologicalProcessangiogenesiscellGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/04/200712/10/2007Screening86159925
719Human Lung Fibroblast Proliferation Assayangiogenesis_modulators_secondarynonProligerativebiologicalProcessangiogenesiscellGrowthphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/200727/08/2013Screening84879937
1008Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1BCL2A1Bcl-2-related protein A1BCL2A1_modulatorsnonProligerativebiologicalProcessapoptosisPPI_FLINTtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/01/200827/03/2008Screening194826237
2129Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL).BCL2L1Bcl-2-like protein 1BCL2L1_modulatorsnonProligerativebiologicalProcessapoptosisbindingFP_PPItargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/11/200915/06/2010Screening3149982199
2462Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis.BCL2L11Bcl-2-like protein 11BCL2L11_inhibitorsnonProligerativebiologicalProcessapoptosisenzymeActLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/03/201003/03/2010Screening325630216
2732HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stressDDIT3DNA damage-inducible transcript 3 proteinDDIT3_inhibitorsnonProligerativebiologicalProcessapoptosisexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/03/201031/03/2010Screening2186548241
463141Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3CASP3Caspase-3procaspase3ActivatorsnonProligerativebiologicalProcessapoptosisenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/08/201007/01/2011Screening326024350
923qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Regioncaspase1InhibitorsnonProligerativebiologicalProcessapoptosisInhibitionenzymeActFlintphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200712/07/2010Confirmatory73912779
504462uHTS fluorescent assay for identification of inhibitors of ATG4BATG4BCysteine protease ATG4BATG4B_inhibitorsnonProligerativebiologicalProcessautophagyenzymeActphenotypic&targetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/201116/03/2011Screening3401191734
463193High-content cell-based screening for modulators of autophagyautophagy imaging assaynonProligerativebiologicalProcessautophagyimaging localizationphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway03/09/201003/09/2010Screening1945281903
782uHTS for Small Molecule Inhibitors of Eukaryotic Translation InitiationEIF4EEukaryotic translation initiation factor 4EEIF4E_inhibitionnonProligerativebiologicalProcessautophagyPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/07/200704/03/2011Screening217332799
2216Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complexRanGTP-Importin-beta complex inhibitorsnonProligerativebiologicalProcesscellDivisionPPI_FRETphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/12/200923/12/2009Screening3023873282
1024HTS Assay for Activators of Cytochrome P450 2A9CYP2C9Cytochrome P450 2C9CYP2C9_activatorsnonProligerativebiologicalProcesscytochromesRolesenzymeActLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/01/200820/09/2010Screening958581368
cell growth assays at ChEMBLcytotoxnonProligerativebiologicalProcesscytotoxicitycellGrowthphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted
1665High Throughput Imaging Assay for Beta-CateninCTNNB1Catenin beta-1betaCateninTranslocationnonProligerativebiologicalProcessdementiaalexaFluorImagingtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/04/200930/12/2010Confirmatory193542587
602162Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound SetABCB6ATP-binding cassette sub-family B member 6ABCB6_inhibitorsnonProligerativebiologicalProcessdrugTransportdrugTransporttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/12/201128/12/2011Screening362098692
504411Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB)DAGLBDiacylglycerol lipase-betaDAGLB_inhibitorsnonProligerativebiologicalProcessendocannabinoidSignalingenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/03/201103/03/2011Screening343468202
1865Quantitative High-Throughput Screen for Regulators of Epigenetic ControlEpigeneticControlnonProligerativebiologicalProcessEpigeneticControlreporterGFPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/200910/07/2009Confirmatory272097537
602363Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity start codon recognitionnonProligerativebiologicalProcessgeneRegulationyeastGrowthLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/03/201212/03/2012Screening347159450
488896HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_ActivitySCARB1Scavenger receptor class B member 1SCARB1nonProligerativebiologicalProcessLipid transportuptaketargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201025/10/2010Screening3192043065
624037Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5Muscarinic acetylcholine receptor M5CHRM5nonProligerativebiologicalProcessM4_AcChBiology[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/04/201209/05/2012Screening363803698
624040Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5Muscarinic acetylcholine receptor M5CHRM5nonProligerativebiologicalProcessM4_AcChBiology[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/04/201209/05/2012Screening3638032133
624038Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5Muscarinic acetylcholine receptor M5CHRM5nonProligerativebiologicalProcessM4_AcChBiology[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/04/201209/05/2012Screening3638031081
1362Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary ScreenmitochondrialFusionnonProligerativebiologicalProcessmitochondrialFusiondifferentialGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/07/200817/07/2008Screening1941534011
485298qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial FusionmitochondrialFusionnonProligerativebiologicalProcessmitochondrialFusiondifferentialGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/09/201029/09/2010Confirmatory322166738
1377HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells.necrosisByCaspaseInhibitorsnonProligerativebiologicalProcessnecrosisATP_lumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/08/200811/08/2008Screening217101832
493091uHTS Colorimetric assay for identification of inhibitors of Scp-1CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1CTDSP1_inhibitorsnonProligerativebiologicalProcessnervousSystemDevelopmentenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/01/201126/01/2011Screening3406962986
651723MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_ActivityPGC1aActivatorsnonProligerativebiologicalProcessOxidative Metabolic FunctionacetylationFRETphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/10/201228/10/2012Screening345870740
651687MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_ActivityPGC1aInhibitorsnonProligerativebiologicalProcessOxidative Metabolic FunctionacetylationFRETphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/10/201223/10/2012Screening345870601
624377Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1)ASAP1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1ASAP1_inhibitorsnonProligerativebiologicalProcessprospectiveBiologyenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/201210/07/2012Screening362577680
1416Primary cell-based high-throughput screening assay to measure PERK inhibitionEIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3PERK_inhibitorsnonProligerativebiologicalProcessproteinMisfoldingenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/10/200816/06/2010Screening217959370
1381HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules.DyneinTransportnonProligerativebiologicalProcessproteinTransportimagingGFPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/08/200818/08/2008Screening2199021036
761HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtypeRAS_inhibitorsnonProligerativebiologicalProcessRAS_pathwaysenzymeActFlintphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/07/200725/10/2009Screening194628398
739Modulators of Post-Golgi TransportModulators of Post-Golgi TransportnonProligerativebiologicalProcesssecretionPathyeastCellGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/06/200704/10/2007Screening97509875
738Screening for Modulators of Post-Golgi Transport, Control StrainModulators of Post-Golgi TransportnonProligerativebiologicalProcesssecretionPathyeastCellGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/06/200704/10/2007Screening975184851
504408Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_ActivityHSF1Heat Shock Factor-1HSF1_activatorsnonProligerativebiologicalProcessstressResponseexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/03/201107/03/2011Screening3011705173
2716Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301SUMOylationInhibitorsnonProligerativebiologicalProcessSUMOylationyeastGrowthAtpLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/03/201029/03/2010Screening3184583322
1814MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activatorsaSynucleinExpressionActivatorsnonProligerativebiologicalProcesssynucleinEffectexpressionReporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/06/200914/12/2009Screening30380121690
588473uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complexCRHBPCorticotropin-releasing factor-binding proteinCRHBP_agonistsnonProligerativebiologicalProcesstoolCompounds[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/10/201108/10/2011Screening3489231622
488922Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9KCNK9two-pore domain potassium channelKCNK9_blockersnonProligerativebiologicalProcesstoolCompoundsTlInfluxtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201001/11/2010Screening3056103794
804Screen for Chemicals that Shorten Yeast LifespanlifespannonProligerativebiologicalProcesstoolCompoundsyeastGrowthphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/09/200716/11/2007Screening138737710
720700Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1).PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 , Phosphoinositide phospholipase CPLCG1nonProligerativebiologicalProcesstoolCompoundsMultiDiseasesenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201328/01/2014Screening3699533123
651999uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assayCOPS5COP9 signalosome complex subunit 5COPS5nonProligerativebiologicalProcessUbiquitination enzymeActFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/01/201330/01/2013Screening3638401401
2544uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphataseALPIIntestinal-type alkaline phosphataseALPI_inhibitorsnonProligerativebiologicalProcessalcalinePhosphataseenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/03/201013/01/2011Screening330392393
2806uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphataseALPIAlkaline phosphataseALPI_inhibitorsnonProligerativebiologicalProcessalcalinePhosphataseenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/201012/01/2011Screening331670664
1259354Small-molecule inhibitors of ST2 (IL1RL1)IL1RL1Interleukin-1 receptor-like 1IL1RL1nonProligerativerespiratorybronchial diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/01/201802/01/2018Screening759241804
602410Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3KCNK3Potassium channel subfamily K member 3KCNK3nonProligerativecardioVasculararterial disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/201216/03/2012Screening3396742841
2642Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channelsKCNQ1Potassium voltage-gated channel subfamily KQT member 1KCNQ1nonProligerativecardioVascularcongenital heart diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/03/201018/11/2010Screening3056103878
2648Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channelsKCNQ1Potassium voltage-gated channel subfamily KQT member 1KCNQ1nonProligerativecardioVascularcongenital heart diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/03/201018/11/2010Screening3056101082
1347048Natriuretic polypeptide receptor (hNpr1) antagonism - Primary qHTSNPR1Atrial natriuretic peptide receptor 1NPR1nonProligerativecardioVascularcongestive heart failuretargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/05/201927/02/2020Other761681231
1511Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agentsKCNH2Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2KCNH2nonProligerativecardioVascularRare genetic cardiac diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/01/200927/03/2010Screening3056101552
720551qHTS for Inhibitors of KCHN2 3.1: Wildtype qHTSKCNH2Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2KCNH2nonProligerativecardioVascularRare genetic cardiac diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/07/201331/07/2013Confirmatory3436661267
798Factor XIa 1536 HTSF11Coagulation factor XIF11_modulationnonProligerativecardioVascularantithrombotic enzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/09/200707/10/2008Screening218707302
800Factor XIIa 1536 HTSF12Coagulation factor XIIF12_modulationnonProligerativecardioVascularantithrombotic enzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/09/200704/03/2011Screening217430649
1046Thrombin 1536 HTSF2ProthrombinF2_modulationnonProligerativecardioVascularantithrombotic enzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/02/200807/10/2008Screening217233557
2520uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assayAPLNRApelin receptorAPLNR_agonistsnonProligerativecardioVascularhypertensionbetaArrestintargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/03/201013/01/2011Screening330348347
743397HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_ActivityCACNA1DVoltage-dependent N-type calcium channel subunit alpha-1BCACNA1D_inhibitorsnonProligerativecardioVascularhypertensionPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/04/201408/04/2014Screening335531328
1671463High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activityGC-A_PAMsnonProligerativecardioVascularhypertensioncGMP_FRET_competitionphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/12/202108/12/2021Screening370293519
707Novel sEH inhibitors for the therapeutic treatment of hypertension and inflammationEPHX2Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2sEH_inhibitorsnonProligerativecardioVascularhypertensionenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/05/200702/05/2007Screening90640310
1910Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor PathwayHIF_expressionActivatorsnonProligerativecardioVascularischemiaHIF_expressionReporter Lumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/08/200908/10/2009Screening300341950
588492uHTS identification of small molecule modulators of myocardial damagemyocardial damagenonProligerativecardioVascularmyocardial infarctioncellViability_ATP_lUMIphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201112/10/2011Screening3592442272
1920062High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activityGC-B_PAMsnonProligerativecardioVascularmyocardialFibrosiscGMP_FRET_competitionphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/02/202416/02/2024Screening370293399
504339qHTS Assay for Inhibitors of JMJD2A-Tudor DomainKDM4ALysine-specific demethylase 4AKDM4AnonProligerativebiologicalProcessepigeneticsalphaScreentargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201122/02/2011Confirmatory38452716920
1663MLPCN Platelet Activation -Dense Granule ReleaseplateletActivationInhibitorsnonProligerativehematologicthrombosisATP_lumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/04/200909/04/2009Screening302451661
1775Profiling compound fluorescence on Avidin Beads with 488 nm excitation and 530 nm emissionfluorescentCompoundsnonProligerativecounterscreencounterscreenavidinBeadsFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/05/200924/05/2009Other217453825
1776Profiling compound fluorescence on GSH Beads with 488 nm excitation and 530 nm emissionfluorescentCompoundsnonProligerativecounterscreencounterscreenGshBeadsFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/05/200928/03/2011Other194826489
709Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nmfluorescentCompoundsnonProligerativecounterscreencounterscreenautofluorescencephenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/05/200725/05/2007Screening654203590
589qHTS Assay for Spectroscopic Profiling in 4-MU Spectral RegionfluorescentCompoundsnonProligerativecounterscreencounterscreenFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/02/200701/03/2007Other584646214
590qHTS Assay for Spectroscopic Profiling in A350 Spectral RegionfluorescentCompoundsnonProligerativecounterscreencounterscreenFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/02/200701/03/2007Other584646427
593qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral RegionfluorescentCompoundsnonProligerativecounterscreencounterscreenFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/02/200727/03/2007Other58463532
463104uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assayIRE1-XBP1 pathway activatorsnonProligerativecytoprotectioncellRecoveryexprressionReporterLuciphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/08/201014/01/2011Screening3316711099
2052HTS for developing T Cell Immune ModulatorsITGALIntegrin alpha L, Integrin alpha-L , VWFA domain-containing proteinITGALnonProligerativedermatologyskin diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/10/200902/03/2010Screening326271221
463082Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH)PLA2G7Platelet-activating factor acetylhydrolasePLA2G7nonProligerativedermatologyskin diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/08/201003/08/2010Screening3260244934
2205HCS assay for microtubule stabilizersTUBBTubulin beta chainTUBBnonProligerativedermatologyskin diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/12/200915/12/2009Screening1958211625
639HTS of Estrogen Receptor- alpha Coactivator Binding PotentiatorsESR1Estrogen receptor, Estrogen receptorESR1_modulatorsnonProligerativereproductiveSystemmenopauseSymptomsPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/03/200723/04/2007Screening860951151
2557HTS for Identification of VLA-4 Allosteric Modulators from MLPCN libraryITGA4Integrin alpha-4ITGA4nonProligerativegastroIntestinalintestinal diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201023/07/2010Screening326888645
1645858OTUD3 deubiquitinase inhibition: Primary qHTSOTUD3OTU domain-containing protein 3OTUD3nonProligerativegastroIntestinalintestinal diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other47480334
2546VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activityRORCNuclear receptor ROR-gammaRORCnonProligerativegastroIntestinalintestinal diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/03/201013/03/2010Confirmatory30406010600
624170qHTS for Inhibitors of Glutaminase (GLS)GLSglutaminase , Glutaminase kidney isoform, mitochondrialGLSnonProligerativegeneticDisorderautosomal recessive diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/201222/05/2012Confirmatory405291844
504700Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complexPRKACBcAMP-dependent protein kinase catalytic subunit betaPRKACBnonProligerativegeneticDisordercardioacrofacial dysplasia 2targetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/04/201122/04/2011Screening343468273
1508649Cell-based coincidence reporter assay to measure PMP22 gene transcription in S16 Pmp22-F2sN cells - Primary screenPMP22Peripheral myelin protein 22PMP22nonProligerativegeneticDisorderchromosomal disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/03/202131/01/2022Confirmatory42576834
886qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II)HSD17B103-hydroxyacyl-CoA dehydrogenase type-2HSD17B10nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/12/200712/07/2010Confirmatory720722464
893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4HSD17B103-hydroxyacyl-CoA dehydrogenase type-2HSD17B10nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/12/200706/07/2010Confirmatory739125649
624414qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1)MCOLN1Mucolipin-1MCOLN1nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/07/201226/07/2012Screening400814482
493208Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: SytravonMTORSerine/threonine-protein kinase mTORMTORnonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/02/201114/02/2011Confirmatory43989342
522Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1)NR5A1Steroidogenic factor 1NR5A1nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/11/200603/04/2007Screening649081225
525Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1)NR5A1Steroidogenic factor 1NR5A1nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/11/200603/04/2007Screening64908359
651724qHTS Assay for Inhibitors of the CtBP/E1A InteractionRBBP8DNA endonuclease RBBP8RBBP8nonProligerativegeneticDisorderdevelopmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201229/10/2012Screening3352141652
1224905High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunitsGNAI3Guanine nucleotide-binding protein GGNAI3nonProligerativegeneticDisorderear malformationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/11/201618/12/2017Screening204125876
1947Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the serine hydrolase family member Fam108B.ABHD17BAlpha/beta hydrolase domain-containing protein 17BABHD17BnonProligerativegeneticDisordergenetic, familial or congenital diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/09/200915/06/2010Screening302663993
799Identification of Molecular Probes that Activate MRP-1ABCC1Multidrug resistance-associated protein 1ABCC1_activatorsnonProligerativegeneticDisorderPseudoxanthoma elasticum cellDeathGrowthtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/09/200720/11/2007Screening138717842
652017Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM)SMARCA2cDNA FLJ36757 fis, clone UTERU2018522, highly similar to Human transcriptional activator hSNF2a, cDNA FLJ53181, highly similar to Probable global transcription activator SNF2L2, Probable global transcription activator SNF2L2 , SMARCA2 protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2SMARCA2nonProligerativegeneticDisorderRare genetic developmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/02/201306/02/2013Screening3689273838
1259422Luminescence cell-based high throughput primary assay to identify inhibitors of TEAD-YAP interaction.YAP1Transcriptional coactivator YAP1YAP1nonProligerativegeneticDisorderRare genetic developmental defect during embryogenesistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/07/201831/07/2018Screening6394289218
588591qHTS for Inhibitors of Polymerase EtaPOLHDNA polymerase etaPOLHnonProligerativegeneticDisorderRare genetic skin diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/10/201120/10/2011Confirmatory3887174730
720704Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3).PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3PLCB3nonProligerativegeneticDisorderspondylometaphyseal dysplasia with corneal dystrophytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201314/11/2013Screening369953662
720509Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]FGBFibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]FGB_inhibitorsnonProligerativehematologiccoagulation protein diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/201310/07/2013Screening369953760
720508Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]FGBFibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]FGB_inhibitorsnonProligerativehematologiccoagulation protein diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/201310/07/2013Screening369953498
540303qHTS for Inhibitors of Cell Surface uPA GenerationPLAUUrokinase-type plasminogen activatorPLAUnonProligerativehematologicinherited bleeding disorder, platelet-typetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/07/201127/07/2011Confirmatory3252471021
624330Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory ScreensRACGAP1Rac GTPase-activating protein 1RACGAP1nonProligerativehematologicnormocytic anemiatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/06/201203/07/2012Confirmatory3420592057
504454HTS for Beta-2AR agonists via FAP methodADRB2Beta-2 adrenergic receptorADRB2_activatorsnonProligerativeimmuneasthmabetaArrestintargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/201121/09/2011Screening3392971446
1053197Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE)SIAESialate O-acetylesteraseSIAEnonProligerativeimmuneautoimmune diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/07/201428/07/2014Screening3699332555
449Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism PotentiatorsS1PR1Sphingosine 1-phosphate receptor 1S1PR1nonProligerativeimmuneautoimmune disorder of the nervous systemtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/07/200601/11/2007Screening55710315
1159521qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathwayRORCRORCgammaRORCgammaPathwayInhibitorsnonProligerativeimmuneautoimmune disordersexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/06/201525/06/2015Confirmatory7671874
2551qHTS for inhibitors of ROR gamma transcriptional activityRORCNuclear receptor ROR-gammaRORCgammaPathwayInhibitorsnonProligerativeimmuneautoimmune disordersexpressionReportertargetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedcompletednotStarted15/03/201015/03/2010Confirmatory30543916717
651800Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe TCR-CD3 interactionnonProligerativeimmuneautoimmuneDisordersPPI_FPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/11/201219/11/2012Screening3625741343
1259398human cGAS chemiluminescence screenCGASCyclic GMP-AMP synthasecGAS_inhibitorsnonProligerativeimmuneautoimmuneDisordersenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201804/01/2019Screening281243218
1259399mouse cGAS chemiluminescence screenCGASCyclic GMP-AMP synthasecGAS_inhibitorsnonProligerativeimmuneautoimmuneDisordersenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201804/01/2019Screening160326237
1259397mouse cGAS RapidFire screenCGASCyclic GMP-AMP synthasecGAS_inhibitorsnonProligerativeimmuneautoimmuneDisordersenzymeActMassSpecttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201804/01/2019Screening123258226
652197MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_ActivityERAP1Endoplasmic reticulum aminopeptidase 1ERAP1_inhibitorsnonProligerativeimmuneautoimmuneDisordersenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/03/201327/03/2013Screening335777499
1919969qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathwayAntioxidant Response ElementnonProligerativeimmuneCOPDexpressionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/01/202430/01/2024Tox217671943
624171qHTS of Nrf2 ActivatorsNFE2L2NFE2 like bZIP transcription factor 2, Nuclear factor erythroid 2-related factor 2Nrf2 activatorsnonProligerativeimmuneCOPDexpressionReporterphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completednotStartedcompletedcompletedcompletedcompletedcompletedcompletednotStarted22/05/201222/05/2012Confirmatory4038711243
1566uHTS luminescence assay for the identification of compounds that inhibit NOD2NOD2Nucleotide-binding oligomerization domain-containing protein 2NOD2nonProligerativeimmuneCrohn's diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/03/200930/12/2010Confirmatory2923231836
485317HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSGFERFAD-linked sulfhydryl oxidase ALRALR activatorsnonProligerativeimmunefibrosisenzymeActtargetBasedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablenotStartednotStartednotStarted29/09/201018/10/2010Screening28872810857
743247Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_ActivityfibronectinDepositionnonProligerativeimmunefibrosisfibronectinAccumulationFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/01/201413/01/2014Screening342865297
602163Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA)MSRAMitochondrial peptide methionine sulfoxide reductase , peptide-methionineMSRAnonProligerativeimmunefibrosisenzymeActtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/01/201203/01/2012Screening3620261074
1274uHTS of small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)NCF1Neutrophil cytosol factor 1p47phoxInhibitorsnonProligerativeimmunefibrosisbindingFPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/05/200803/06/2008Screening2174541142
1259400qHTS Assay for Antagonists of the Relaxin Receptor RXFP1Taking the negative queue for PMsRXFP1Relaxin receptor 1relaxin PMsnonProligerativeimmunefibrosiscAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/03/201820/03/2018Screening3501772058
630HTS of Smad transcription factor inhibitorsSMAD3Mothers against decapentaplegic homolog 3SMAD3nonProligerativeimmunefibrosisbindingFRETtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/03/200723/03/2007Screening88033251
2676qHTS Assay for Agonists of the Relaxin Receptor RXFP1RXFP1Relaxin receptor 1RXFP1nonProligerativeimmunefibrosiscAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/03/201015/03/2018Confirmatory3621981084
588855qHTS for Inhibitors of TGF-bTGFB1HSPC193, Mothers against decapentaplegic homolog 3TGFB1nonProligerativeimmunefibrosisGFP ligand internalizationtargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/12/201106/12/2011Confirmatory4033454970
1497HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay.ITGB2Integrin beta-2ITGB2nonProligerativeimmuneimmune deficiency diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/01/200929/12/2010Screening92518501
1259416Toxoplasma gondii inhibition HTS in the presence of IFN-yIFNGInterferon gammaIFNGnonProligerativeimmuneImmune dysregulation disease with immunodeficiencytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/07/201827/07/2018Screening672752509
1645855USP17 deubiquitinase inhibition: Primary qHTSUSP17L5Ubiquitin carboxyl-terminal hydrolase 17-like protein 5USP17L5nonProligerativeimmuneimmunodeficiency diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other474803075
796IL-1B Induced NFkB Translocation - Primary Screen NFkB_Translocation_inhibitorsnonProligerativeimmuneimmunomodulationimagingTranslocationphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/09/200726/03/2009Screening94265409
2796Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR)AHRAryl hydrocarbon receptorAHR_activatorsnonProligerativeimmuneimmunomodulationreporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/04/201005/08/2010Screening3247477988
1347428Primary qHTS assay for inhibitors of Activation Induced Cytidine Deaminase (AID): AID signalAICDASingle-stranded DNA cytosine deaminaseAICDA_inhibitorsnonProligerativeimmuneimmunomodulationenzymeActFrettargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/06/202015/06/2021Confirmatory90878289
887qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase)ALOX15Polyunsaturated fatty acid lipoxygenase ALOX15ALOX15_inhibitorsnonProligerativeimmuneimmunomodulationenzymeActAbstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/12/200706/07/2010Confirmatory731741034
696Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphataseALPGAlkaline phosphatase, germ cell typeALPG_activatorsnonProligerativeimmuneimmunomodulationenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/04/200730/08/2010Confirmatory957291178
651702Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound LibraryCTL granule exocytosisnonProligerativeimmuneimmunomodulationflowCytometryphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201204/03/2013Screening3638752400
1246Primary HTS assay for chemical inhibitors of TNF alpha stimulated E-Selectin expressionSELEE-SelectinE-selectinExpressionnonProligerativeimmuneimmunomodulationimmunostainingtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/03/200809/04/2008Screening118096843
861Primary cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 bindinginhibitors of TLR4-MyD88 bindingnonProligerativeimmuneimmunomodulationPPI_enzymeComplementationphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/11/200721/11/2007Screening195980357
819Primary HTS assay for chemical potentiators of IL-1B stimulated NFkB nuclear translocationNFkB nuclear translocationnonProligerativeimmuneimmunomodulationimmunostainingImagingphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/10/200726/03/2009Screening94231282
435022uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activationNFKB1_activationnonProligerativeimmuneimmunomodulationnfkbReporterLumiphenotypic0records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/06/201014/01/2011Screening3316701077
435003uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activationNFKB1_activationnonProligerativeimmuneimmunomodulationnfkbReporterLumiphenotypic0records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/06/201014/01/2011Screening3303921733
932Primary cell-based high throughput screening assay to measure STAT1 activationSTAT1Signal transducer and activator of transcription 1-alpha/betaSTAT1 activationnonProligerativeimmuneimmunomodulationexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200726/09/2011Screening1959805134
802Primary HTS assay for chemical inhibitors of TNF alpha stimulated VCAM1 expressionVCAM1VCAM1 VCAM1_expressionnonProligerativeimmuneimmunomodulationimmunostainingtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/09/200719/11/2007Screening94498457
871Primary cell-based high throughput screening assay to measure STAT3 activationSTAT3Signal transducer and activator of transcription, Signal transducer and activator of transcription 3STAT3nonProligerativeimmuneimmunomodulationexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/12/200711/09/2008Screening1946661772
862Primary cell-based high throughput screening assay to measure STAT3 inhibitionSTAT3Signal transducer and activator of transcription, Signal transducer and activator of transcription 3STAT3nonProligerativeimmuneimmunomodulationexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/11/200711/09/2008Screening1946661722
743279qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary ScreenIL1BInterleukin-1 betaIL-1b InflammasomenonProligerativeimmuneInflammation CASP COPDIL-1B productionphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway11/02/201413/02/2014Screening36205117187
588358HTS to Find Inhibitors of Pathogenic Pemphigus AntibodiespemphigusAntibodiesInhibitorsnonProligerativeimmunepemphigusantigenAntibodyBindingFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/09/201122/09/2011Screening3113441495
920Primary cell-based high throughput screening assay to measure STAT1 inhibitionSTAT1Signal transducer and activator of transcription 1-alpha/betaSTAT1nonProligerativeimmunePrimary immunodeficiency due to a defect in innate immunitytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/12/200711/09/2008Screening195980695
588511Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A)ANO1Anoctamin-1ANO1_inhibitorsnonProligerativeimmunepsoriasis[Cl-]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/10/201127/03/2013Screening3065023633
1053188Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based System Using Plate Reader - 7124-01_Inhibitor_SinglePoint_HTS_ActivityInhibitors of CD40 SignalingnonProligerativeimmunerheumatoidArthritisnfkbReporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/07/201409/07/2015Screening82418778
619Fluorescence polarization assay for PLK1 inhibitorsPLK1Serine/threonine-protein kinase PLK1PLK1nonProligerativeimmunetype II hypersensitivity reaction diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/03/200708/08/2007Screening97099518
720504qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary ScreenPLK1Serine/threonine-protein kinase PLK1PLK1nonProligerativeimmunetype II hypersensitivity reaction diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/07/201309/07/2013Confirmatory36406510181
485Primary HTS Assay for S1P3 AntagonistsS1PR3Sphingosine 1-phosphate receptor 3S1PR3nonProligerativeimmunetype II hypersensitivity reaction diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/10/200611/06/2010Screening169141462
1159537qHTS screening for TAG (triacylglycerol) accumulators in algaefuelBiosynthesisnonProligerativeindustriallipidBiosynthesisTG_levels_FLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/08/201524/07/2017Screening43680367
602429uHTS identification of SUMO1-mediated protein-protein interactionsSUMO1Small ubiquitin-related modifier 1SUMO1cancercancerresistanecToRadiationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/03/201220/03/2012Screening3638401202
540275HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1TRPV1Transient receptor potential cation channel subfamily V member 1TRPV1nonProligerativemetabolicEndocrineAbnormality of metabolism/homeostasistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/07/201120/07/2011Screening316642617
1508602Cell-based high throughput primary assay to identify activators of GPR151GPR151G-protein coupled receptor 151GPR151nonProligerativemetabolicEndocrinebody fat percentagetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/07/202031/07/2020Screening6427016746
1016Luminescent assay for identification of activators of bovine intestinal alkaline phosphataseALPIAlkaline phosphataseALPI_activatorsnonProligerativemetabolicEndocrinecholesterolLevelsenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/01/200827/08/2010Screening195570326
2524uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphataseALPIIntestinal-type alkaline phosphataseALPI_activatorsnonProligerativemetabolicEndocrinecholesterolLevelsenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/03/201013/01/2011Screening330392537
2805uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphataseALPIAlkaline phosphataseALPI_activatorsnonProligerativemetabolicEndocrinecholesterolLevelsenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/201012/01/2011Screening331670785
1224865Identify inhibitors of HNF4 alpha protein binding to DNANR2A1Hepatocyte nuclear factor 4 alphaHNF4_binding_to_DNA_enhancersnonProligerativemetabolicEndocrinecongenitalDiabetesDNA-Prot_binfingFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/09/201620/09/2016Screening3638391098
1216HTS identification of compounds activating phosphomannose isomerase (PMI) via a fluorescence intensity assay using a near- saturating concentration of mannose 6-phosphatMPIMannose-6-phosphate isomeraseMPInonProligerativemetabolicEndocrinedisorder of glycosylationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/03/200829/09/2010Screening194152656
1220HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphateMPIMannose-6-phosphate isomeraseMPInonProligerativemetabolicEndocrinedisorder of glycosylationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/03/200829/09/2010Confirmatory1941521288
1209HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.MPIMannose-6-phosphate isomeraseMPInonProligerativemetabolicEndocrinedisorder of glycosylationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/03/200820/09/2010Confirmatory194152814
624417qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode)GLP1RGlucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptorGLP1RnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBasedassayID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted26/07/201226/07/2012Confirmatory4051306428
493087Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE)IDEInsulin-degrading enzymeIDEnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/01/201125/01/2011Screening335239245
434962Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE)IDEInsulin-degrading enzymeIDEnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/06/201007/06/2010Screening3247471316
1296Primary screen for compounds that activate Insulin promoter activity in TRM-6 cellsINSInsulin, Insulin [Cleaved into: Insulin B chain; Insulin A chain]INSnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/200822/05/2008Screening1286951039
1273Primary screen for compounds that inhibit Insulin promoter activity in TRM-6 cellsINSInsulin, Insulin [Cleaved into: Insulin B chain; Insulin A chain]INSnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/05/200812/05/2008Screening1279611153
1051Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/02/200827/02/2008Other99314335
1049Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/02/200821/02/2008Other196176782
1048Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/02/200821/02/2008Other99314390
631Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/03/200725/01/2008Screening196177811
1032Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/02/200815/06/2010Screening196176670
731Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPeroxisome proliferator-activated receptor gammaPPARGnonProligerativemetabolicEndocrineendocrine pancreas disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/06/200716/06/2010Screening196177519
485270FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1)HCRTR1Orexin/Hypocretin receptor type 1HCRTR1nonProligerativemetabolicEndocrineEnergy balance, obesityIP1/[Ca++]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/09/201024/09/2010Screening3260245748
540308Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4RMC4RMelanocortin receptor 4MC4RnonProligerativemetabolicEndocrineEnergy balance, obesitybetaArrestintargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/07/201127/07/2011Screening3561603470
624287qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTSGNASGuanine nucleotide-binding protein GGNASnonProligerativemetabolicEndocrinehereditary hypoparathyroidismtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/06/201212/06/2012Confirmatory334825423
2751Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL)PREPLProlyl endopeptidase-likePREPLnonProligerativemetabolicEndocrineinborn disorder of amino acid transporttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/04/201015/06/2010Screening3247472221
1159527qHTS assay to identify small molecule agonists of the RXR signaling pathway:RXRretinoid X receptorRXRA_pathway_agonistsnonProligerativemetabolicEndocrineinsulin sensitizationexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/07/201531/07/2015Confirmatory7671173
686940Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2)NR2F2COUP transcription factor 2NR2F2nonProligerativemetabolicEndocrineinsulin sensitizationexpressionReportertargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/04/201315/04/2013Screening3699532602
1628HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 CellsInsulinPromoterDownRegulationnonProligerativemetabolicEndocrineinsulinSignalingimagingGFPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/03/200930/12/2010Confirmatory192372925
1625HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 CellsInsulinPromoterDownRegulationnonProligerativemetabolicEndocrineinsulinSignalingimagingGFPphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/03/200930/12/2010Confirmatory192980574
504847Inhibitors of the vitamin D receptor (VDR): qHTSVDRVitamin D3 receptorVDRnonProligerativemetabolicEndocrinenutritional deficiency diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/06/201124/06/2011Confirmatory3940503624
540295TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4RMC4RMelanocortin receptor 4MC4RnonProligerativemetabolicEndocrineobesitytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/07/201123/07/2011Screening3561601703
1656High Throughput Imaging Assay for Hepatic Lipid Droplet Formation LipidDropletFormationnonProligerativemetabolicEndocrineobesityimagingBodipyphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/04/200930/12/2010Screening236434954
720543Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4).ABHD4Abhydrolase Domain Containing 4, N-Acyl Phospholipase BABHD4_inhibitorsnonProligerativemetabolicEndocrineobesityFP_bindingtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/07/201324/07/2013Screening3699532005
1030qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)ALDH1A1Aldehyde dehydrogenase 1A1ALDH1A1_inhibitorsnonProligerativemetabolicEndocrineobesityenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/01/200815/03/2010Confirmatory21688116026
2685qHTS Assay for Lipid Storage Modulators in Drosophila S3 CellslipidStorageInhibitorsnonProligerativemetabolicEndocrineobesitylipidStainFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/03/201025/03/2010Confirmatory3208582061
651560uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assayACP1Low molecular weight phosphotyrosine protein phosphataseACP1_inhibitorsnonProligerativemetabolicEndocrineobesity associated insulin resistance and  the metabolic syndromeenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/09/201204/09/2012Screening363840817
1259318uHTS identification of small molecule modulators of Rev-erb Alpha.Rev-erb AlphanonProligerativemetabolicEndocrineobesity, diabetes and hyperlipidemiaFP_bindingphenotypicassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/05/201727/05/2017Screening3715402956
651582uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assayTriglycerideAccumulationInhibitorsnonProligerativemetabolicEndocrineobesity, diabetes and hyperlipidemiaTG_levels_FLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/09/201212/09/2012Screening2267211501
602281Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5)PLIN5Perilipin-5PLIN5nonProligerativemetabolicEndocrineobesity, diabetes, and cardiovascular diseaseE.complementation PPI bindingtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/02/201229/02/2012Screening3638032851
651710FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2RAD52DNA repair protein RAD52 homologRAD52nonProligerativemetabolicEndocrinesystolic blood pressuretargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201226/10/2012Screening3520741608
435005Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis.b cell apoptosisnonProligerativemetabolicEndocrineT1DiabetescellDeathphenotypicTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted18/06/201018/06/2010Screening3035002435
624172qHTS of GLP-1 Receptor AgonistsGLP1RGlucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptorGLP1R agonistsnonProligerativemetabolicEndocrineT2DiabetescAMPtargetBasedassayID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted22/05/201222/05/2012Confirmatory37346223
624417qHTS of GLP-1 Receptor Inverse Agonists: (PAM Mode) (Taking the negative queue for PAMs)GLP1RGlucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptorGLP1R PAMsnonProligerativemetabolicEndocrineT2DiabetescAMPtargetBasedassayID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaycompleted26/07/201226/07/2012Confirmatory4051306428
743287Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_ActivityGlucose-dependent insulin secretionnonProligerativemetabolicEndocrineT2diabetessecretion-associated reporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/02/201424/02/2014Screening3711082287
652154HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_ActivityPAX8Paired box protein Pax-8PAX8nonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/201321/03/2013Screening3539504145
720707qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screenRAPGEF3Rap guanine nucleotide exchange factor 3RAPGEF3nonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201331/10/2013Confirmatory364614268
720709qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screenRAPGEF3Rap guanine nucleotide exchange factor 3RAPGEF3nonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201331/10/2013Confirmatory364614517
1479Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2THRBThyroid hormone receptor betaTHRBnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/01/200907/01/2009Confirmatory276265806
493084qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Agonists.TRHRThyrotropin-releasing hormone receptorTRHRnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/01/201125/01/2011Screening361330651
504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaignTSHRThyrotropin receptorTSHRnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/06/201125/06/2011Screening329153670
504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaignTSHRThyrotropin receptorTSHRnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/06/201127/06/2011Screening329153670
926qHTS Assay for Agonists of the Thyroid Stimulating Hormone ReceptorTSHRThyrotropin receptorTSHRnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200706/07/2010Confirmatory72026352
938qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293TSHRThyrotropin receptorTSHRnonProligerativemetabolicEndocrinethyroid diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/12/200706/07/2010Confirmatory720261794
2380uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell linebeta-cell replicationnonProligerativemetabolicEndocrinetype I and type II diabetescellGrowth_ATP_lUMIphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/02/201013/01/2011Screening330392956
743266qHTS for PTHR1 Agonists: Primary ScreenPTH1RParathyroid hormone/parathyroid hormone-related peptide receptorPTH1RnonProligerativemuculoEskeletalConnectivebone development diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/01/201430/07/2019Confirmatory405685308
624296A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.GMNNGemininGMNNnonProligerativemuculoEskeletalConnectivebone diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/06/201215/06/2012Confirmatory3432349888
624297A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.GMNNGemininGMNNnonProligerativemuculoEskeletalConnectivebone diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/06/201215/06/2012Confirmatory3422796233
488847RNA aptamer-based HTS for inhibitors of GRK2GRK2Beta-adrenergic receptor kinase 1GRK2nonProligerativemuculoEskeletalConnectivebone diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/10/201015/03/2011Screening3279391924
618Luminescent HTS for small molecule inhibitors of MT1-MMP transcriptionMMP14Matrix metalloproteinase-14MMP14nonProligerativemuculoEskeletalConnectivebone diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/03/200727/08/2010Confirmatory86733537
651647uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assayMMP14Matrix metalloproteinase-14MMP14nonProligerativemuculoEskeletalConnectivebone diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/10/201218/10/2012Screening361500222
492956Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2)PAFAH2Platelet-activating factor acetylhydrolase 2, cytoplasmicPAFAH2nonProligerativemuculoEskeletalConnectivebone fracture related measurementtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/12/201002/12/2010Screening3352393325
2825uHTS Luminescent assay for identification of inhibitors of NALP3 in yeastNLRP3NACHT, LRR and PYD domains-containing protein 3, NACHT, LRR and PYD domains-containing protein 3NLRP3nonProligerativemuculoEskeletalConnectiveconnective tissue diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/05/201013/01/2011Screening3303921295
485272Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS)PADI4Protein-arginine deiminase type-4PADI4nonProligerativemuculoEskeletalConnectiveconnective tissue diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/09/201024/09/2010Screening3260221334
504734Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding.TLR9Toll-like receptor 9TLR9nonProligerativemuculoEskeletalConnectiveconnective tissue diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/05/201109/05/2011Screening343468734
2242qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe DiseaseGAALysosomal alpha-glucosidaseGAAnonProligerativemuculoEskeletalConnectivefamilial cardiomyopathytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/01/201012/01/2010Confirmatory199169715
2100qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of GlycogenGAALysosomal alpha-glucosidaseGAA_inhibitorsnonProligerativemuculoEskeletalConnectivefamilial cardiomyopathytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/11/200905/11/2009Confirmatory3022971165
1672Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1KCNJ2Inward rectifier potassium channel 2KCNJ2nonProligerativemuculoEskeletalConnectivefamilial periodic paralysistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/04/200929/03/2010Screening3056102592
540364Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoterFXNFrataxin, mitochondrialFXNnonProligerativemuculoEskeletalConnectiveFriedreich ataxiatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/08/201108/09/2011Screening3561601985
493008Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)TNNI3Troponin I, cardiac muscleTNNI3nonProligerativemuculoEskeletalConnectivehypertrophic cardiomyopathytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/12/201029/12/2010Screening335239801
493244Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)TNNI3Troponin I, cardiac muscleTNNI3nonProligerativemuculoEskeletalConnectivehypertrophic cardiomyopathytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/02/201117/02/2011Screening335238390
894qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)HPGD15-hydroxyprostaglandin dehydrogenase [NADHPGDnonProligerativemuculoEskeletalConnectivehypertrophic osteoarthropathy, primary, autosomal recessive, 1targetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted17/12/200701/03/2010Confirmatory1484806428
588413uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assayGLI1Zinc finger protein GLI1GLI1nonProligerativemuculoEskeletalConnectivenon-syndromic polydactylytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/201112/03/2012Screening3383282501
1012uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assayALPLAlkaline phosphatase, tissue-nonspecific isozymeALPL_inhibitorsnonProligerativemuculoEskeletalConnectiveboneDiseaseenzymeActLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/01/200830/08/2010Screening195560517
1224904HTS for inhibitors of DUX4-mediated transcriptional activationDUX4Double homeobox protein 4 , DUX4DUX4_inhibitorsnonProligerativemuculoEskeletalConnectivemuscularDystrophyexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/11/201610/10/2017Screening36365289
602340HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_ActivityC2C12_myopathynonProligerativemuculoEskeletalConnectivemyotoxicityATP_lumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/03/201228/03/2012Screening3292742586
588674Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2HIVEP3Schnurri-3Schnurri-3 InhibitorsnonProligerativemuculoEskeletalConnectiveosteoporosisexprressionReporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201117/03/2014Screening3568831841
1285Primary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translationAPPAmyloid-beta A4 protein, Amyloid-beta precursor proteinAPP_inhibitorsnonProligerativenervousSystemADtranslationphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/05/200819/05/2008Screening1937141590
651572Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1)ARFGAP1ADP-ribosylation factor GTPase-activating protein 1ARFGAP1_inhibitorsnonProligerativenervousSystemADenzymeActFlinttargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/09/201218/09/2012Screening362539954
624126Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4Muscarinic acetylcholine receptor M4CHRM4_PAMsnonProligerativenervousSystemAD[Ca++]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/201209/05/2012Screening3638031450
602449uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assaymPTPnonProligerativenervousSystemALS, AD, neurodegenerationabsorbance swellingphenotypicTID2records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/201228/03/2012Screening3638405033
1239High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary ScreenNFKB1Nuclear factor NF-kappa-B p105 subunitNFKB1nonProligerativenervousSystemALS, AD, neurodegenerationexpressionReportertargetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwaynotStarted17/03/200826/03/2009Screening1932653100
485349qHTS Assay for Identifying a Potential Treatment of Ataxia-TelangiectasiaATMSerine-protein kinase ATMATM_modulatorsnonProligerativenervousSystemataxiaTelangiectasiaenzymeActAlphalisatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201004/10/2010Confirmatory322361619
2797Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R)AVPR1AVasopressin V1a receptorAVPR1A_agonistsnonProligerativenervousSystembehavioralDisorders[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/04/201015/06/2010Screening324747813
588475uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complexCRHBPCorticotropin-releasing factor-binding proteinCRHBP_antagonistsnonProligerativenervousSystemdrugAddiction[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/10/201103/01/2012Screening3489232056
652054qHTS of D3 Dopamine Receptor Antagonist: qHTSDRD3Dopaminereceptor3D3_antagonistsnonProligerativenervousSystemdrugAddictioncAMP_reportertargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/02/201321/02/2013Screening3640519106
1259245Modulation of AMPAR-stargazin complexesCACNG2Voltage-dependent calcium channel gamma-2 subunitAMPAStargazinComplexModulatorsnonProligerativenervousSystemepilepsymembranePotentialtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201722/02/2017Other404731400
449739Inhibitors of Cav3 T-type Calcium Channels: Primary ScreenCACNA1HVoltage-dependent T-type calcium channel subunit alpha-1HCACNA1H_inhibitorsnonProligerativenervousSystemepilepsy[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/07/201009/03/2011Screening1047284230
504441Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_ActivityDYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1ADYRK1A_inhibitorsnonProligerativenervousSystemgeneticNeurodevelopmentalDisabilityenzymeActADP_glowtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/03/201110/03/2011Screening3100141321
1203Primary cell-based high-throughput screening assay to identify transcriptional activators of heat shock protein 70 (Hsp70)HSP70heatShockProt70Heat shock 70kDa protein 1AnonProligerativenervousSystemHD, AD, PD, ALS, neurodegenerationexpressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/03/200812/08/2008Screening19617682
651819High-Throughput Screening for Modulators of Cytosolic Chaperonin ActivityMARVELD2MARVEL domain-containing protein 2MARVELD2nonProligerativenervousSystemhearing disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/11/201228/11/2012Screening3622741085
729Primary Cell-Based High-Throughput Screening to Identify Agonists of the Sphingosine 1-phosphate receptor 2 (S1P2)S1PR2Sphingosine 1-phosphate receptor 2S1PR2nonProligerativenervousSystemhearing disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/06/200727/11/2007Screening96879447
736Primary Cell-Based High-Throughput Screening to Identify Antagonists of the Sphingosine 1-phosphate receptor 2 (S1P2)S1PR2Sphingosine 1-phosphate receptor 2S1PR2nonProligerativenervousSystemhearing disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/06/200710/01/2008Screening96879207
651821Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeatscagRnaRepeatsnonProligerativenervousSystemhuntingtonrnaBindingFLINTphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/11/201225/04/2013Screening3689274667
1671202Alphascreen assay for small molecules abrogating mHTT-CaM InteractionHTTHuntingtinHTTnonProligerativenervousSystemHuntington disease and related disorderstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/10/202121/10/2021Screening1898826790
1508623Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter ActivityHTTHuntingtinHTTnonProligerativenervousSystemHuntington disease and related disorderstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/01/202103/04/2021Confirmatory48068449
1688qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP)HTTHuntingtinHTTnonProligerativenervousSystemHuntington disease and related disorderstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/04/200921/04/2009Confirmatory2205712380
1471qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP)HTTHuntingtinHTTnonProligerativenervousSystemHuntington disease and related disorderstargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/12/200820/03/2009Confirmatory223611305
651725qHTS Assay for Inhibitors of the Six1/Eya2 InteractionSIX1Homeobox protein SIX1SIX1nonProligerativenervousSysteminherited auditory system diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201229/10/2012Screening3640532026
1671188Primary qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2)GPT2Alanine aminotransferase 2GPT2nonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/08/202117/08/2021Confirmatory98912236
596qHTS Assay for Tau Filament BindingMAPTMicrotubule-associated protein, Microtubule-associated protein tauMAPTnonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/02/200720/12/2007Confirmatory696681391
1468qHTS for Inhibitors of Tau Fibril Formation, Fluorescence PolarizationMAPTMicrotubule-associated protein, Microtubule-associated protein tauMAPTnonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/12/200830/12/2008Confirmatory2714021048
1671194Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expressionSNCAAlpha-synucleinSNCAnonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/08/202101/09/2021Confirmatory140118236
652106qHTS of alpha-syn InhibitorsSNCAAlpha-synucleinSNCAnonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201314/03/2013Confirmatory368791501
1347073qHTS of TDP-43 Inhibitors: NCGC Sytravon Library ScreenTARDBPTAR DNA-binding protein 43TARDBPnonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/07/201923/07/2019Confirmatory45163203
485290qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1)TDP1Tyrosyl-DNA phosphodiesterase 1TDP1nonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/09/201028/09/2010Confirmatory344442978
686978qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPTTDP1cDNA FLJ13452 fis, clone PLACE1003176, highly similar to Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1TDP1nonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/05/201316/05/2013Confirmatory41682463248
686979qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPTTDP1cDNA FLJ13452 fis, clone PLACE1003176, highly similar to Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1TDP1nonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/05/201316/05/2013Confirmatory41685649238
720702Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)TDP2Tyrosyl-DNA phosphodiesterase 2TDP2nonProligerativenervousSysteminherited neurodegenerative disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201329/10/2013Screening3699531241
560Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA)RORANuclear receptor ROR-alphaRORAnonProligerativenervousSystemintellectual developmental disorder with or without epilepsy or cerebellar ataxiatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200611/04/2007Screening64908979
561Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA)RORANuclear receptor ROR-alphaRORAnonProligerativenervousSystemintellectual developmental disorder with or without epilepsy or cerebellar ataxiatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/12/200603/04/2007Screening64908278
662Cell signaling CRE-BLA (Fsk stim)CREBcyclic-AMP Responsive Element Binding Protein_modulatorsnonProligerativenervousSystemlongTermMemoryreporterLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/04/200712/04/2007Confirmatory696691744
1415Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao.GNAO1Guanine nucleotide-binding protein GGNAO1nonProligerativenervousSystemMendelian neurodevelopmental disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/10/200801/12/2008Screening218528711
1439Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.GNAO1Guanine nucleotide-binding protein GGNAO1nonProligerativenervousSystemMendelian neurodevelopmental disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/12/200801/12/2008Screening218528770
1423Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.GNAO1Guanine nucleotide-binding protein GGNAO1nonProligerativenervousSystemMendelian neurodevelopmental disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/11/200801/12/2008Screening218528750
1456Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary ScreenSLC12A5Solute carrier family 12 member 5SLC12A5nonProligerativenervousSystemmonogenic epilepsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/12/200823/12/2008Other1891324127
422HTS for 14-3-3 protein interaction modulatorsYWHAG14-3-3 protein gammaYWHAGnonProligerativenervousSystemmonogenic epilepsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/06/200612/08/2008Screening157962312
489030uHTS Fluorescent assay for identification of inhibitors of Apaf-1APAF1Apoptotic protease-activating factor 1APAF1_inhibitorsnonProligerativenervousSystemneurodegenerationenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/11/201014/04/2011Screening3316712353
1276Primary screen for compounds that activate Alzheimer's amyloid precursorAPPAmyloid-beta A4 protein, Amyloid-beta precursor proteinAPP_inhibitorsnonProligerativenervousSystemneurodegenerationreporterLuciphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/05/200813/05/2008Screening1934001987
1347071qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary ScreenAPPAmyloid-beta precursor proteinAPP_inhibitorsnonProligerativenervousSystemneurodegenerationyeastsViabilitytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/07/201920/07/2019Confirmatory404343257
1236uHTS for Calpain InhibitorsCAPN2Calpain-2 catalytic subunitcalpainInhibitorsnonProligerativenervousSystemneurodegenerationenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/200814/03/2008Screening218602799
686996VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2CASP6Caspase-6Caspase6InhibitorsnonProligerativenervousSystemneurodegenerationenzymeActFlinttargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/05/201323/05/2013Screening3443181854
588814Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1)CHRM1Muscarinic acetylcholine receptor M1CHRM1_agonistsnonProligerativenervousSystemneurodegeneration[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/11/201109/05/2012Screening3592071189
626Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary ScreenCHRM1Muscarinic acetylcholine receptor M1CHRM1_allosteric_activatorsnonProligerativenervousSystemneurodegeneration[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/200719/09/2007Screening636761938
588819Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1).CHRM1Muscarinic acetylcholine receptor M1CHRM1_PAMsnonProligerativenervousSystemneurodegeneration[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/11/201109/05/2012Screening359207316
652048qHTS of D3 Dopamine Receptor Agonist: qHTSDRD3Dopaminereceptor3D3_agonistsnonProligerativenervousSystemneurodegenerationcAMP_reportertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/02/201312/03/2013Screening4075392380
652051qHTS of D3 Dopamine Receptor Potentiators: qHTSDRD3Dopaminereceptor3D3_PAMsnonProligerativenervousSystemneurodegenerationcAMP_reportertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/02/201321/02/2013Screening4075392380
540317HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone TailsCBX1Chromobox protein homolog 1HP1-betaChromodomainInteractionsInhibitorsnonProligerativenervousSystemneurodegenerationPPI_alphascreentargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/07/201128/07/2011Confirmatory3833632142
1117267Luminescence-based cell-based primary high throughput screening assay to identify activators of Transthyretin (TTR) transcriptionHEL111Transthyretin, TransthyretinHEL111nonProligerativenervousSystemneurodegenerationtranscriptionphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/08/201429/08/2014Screening919091155
1460qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T BindingMAPTMicrotubule-associated protein, Microtubule-associated protein tauMAPTnonProligerativenervousSystemneurodegenerationDFLINT aggregationphenotypic&targetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/12/200830/12/2008Confirmatory2674125703
488975Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT)SLC5A7High affinity choline transporter 1SLC5A7nonProligerativenervousSystemneurodegenerationCh-transport-coupled Na+ flow: MPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/11/201017/11/2010Screening3065022634
652104qHTS of TDP-43 InhibitorsTARDBPTAR DNA-binding protein 43TARDBPnonProligerativenervousSystemneurodegenerationyeastReportertargetBasedTID3records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201314/03/2013Confirmatory4037037150
1481Primary biochemical high-throughput screening assay to measure P97 ATPase inhibitionVCPTransitional endoplasmic reticulum ATPaseVCPnonProligerativenervousSystemneurodegenerationenzymeActtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/01/200916/06/2010Screening217959923
588795qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1).FEN1Flap endonuclease 1FEN1_inhibitorsnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/11/201116/11/2011Confirmatory3862701331
493131Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_ActivityFOSBProtein FosBFOSBnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/01/201131/01/2011Screening3373913330
1259313uHTS identification of small molecule modulators of NR3AGRIN3AGRIN3AnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/05/201713/05/2017Screening3397728480
1974Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1).GSTO1Glutathione S-transferase omega-1GSTO1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/10/200916/06/2010Screening3026633200
1645851Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (IP6K1)IP6K1Inositol hexakisphosphate kinase 1IP6K1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/04/202120/04/2021Confirmatory1432291157
1531Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 WildtypeMAP4K2Mitogen-activated protein kinase kinase kinase kinase 2MAP4K2nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/03/200902/03/2009Screening2894653276
1530Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutantMAP4K2Mitogen-activated protein kinase kinase kinase kinase 2MAP4K2nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/03/200902/03/2009Screening2895391003
2057Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide.MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variantMCL1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/10/200915/06/2010Screening3149982139
1021uHTS of Mcl-1/Bid interaction inhibitorsMCL1Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variantMCL1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/01/200808/01/2008Screening2186022129
1022uHTS of Mcl-1/Noxa interaction inhibitorsMCL1Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variantMCL1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/01/200808/01/2008Screening2173303334
1448Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)MCOLN3Mucolipin-3MCOLN3nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/12/200816/06/2010Screening217959632
602229Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)NR2E3Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b , Photoreceptor-specific nuclear receptorNR2E3nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/01/201226/01/2012Screening3620261281
2300TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3).NR2E3Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b , Photoreceptor-specific nuclear receptorNR2E3nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/01/201015/06/2010Screening314998380
492953Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2)PAFAH1B2Platelet-activating factor acetylhydrolase IB subunit alpha2PAFAH1B2nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/12/201002/12/2010Screening3352394158
1346378qHTS for small molecular inhibitors of PI4K2API4K2APhosphatidylinositol 4-kinase type 2-alphaPI4K2AnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/11/201826/11/2018Screening414643532
652105qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alphaPIP4K2AnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/03/201304/06/2024Confirmatory3288604078
1631qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate KinasePKMPyruvate kinase PKMPKMnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/03/200919/06/2009Confirmatory263662892
485314qHTS Assay for Inhibitors of DNA Polymerase BetaPOLBDNA polymerase betaPOLBnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/09/201029/09/2010Confirmatory3344574509
2130Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1).PPME1Protein phosphatase methylesterase 1PPME1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/11/200915/06/2010Screening3149991683
2235Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1).PPP1CASerine/threonine-protein phosphatase PP1-alpha catalytic subunitPPP1CAnonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/01/201015/06/2010Screening3149992841
652257Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1)PRMT1Protein arginine N-methyltransferase 1PRMT1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/04/201302/04/2013Screening3699534757
727Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK)PTK2Focal adhesion kinase 1PTK2nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/05/200711/09/2007Screening96879811
588621uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assayPTPN5Tyrosine-protein phosphatase non-receptor type 5PTPN5nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/10/201124/10/2011Screening359244887
652163S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_ActivityS100A4Protein S100-A4S100A4nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/03/201322/03/2013Screening352235501
624204uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assaySENP1SENP1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/05/201211/10/2012Screening363840774
2599uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6)SENP6cDNA FLJ11355 fis, clone HEMBA1000141, highly similar to Sentrin-specific protease 6, Sentrin-specific protease 6 , SUMO specific peptidase 6SENP6nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/03/201012/01/2011Screening3303925817
588478A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37UCHL5Ubiquitin carboxyl-terminal hydrolase isozyme L5UCHL5nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/10/201118/10/2016Other3307071075
687016Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotideUHRF1E3 ubiquitin-protein ligase UHRF1UHRF1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/05/201331/05/2013Screening3699532779
743255Inhibitors of USP1/UAF1: Primary ScreenUSP1Ubiquitin carboxyl-terminal hydrolase 1USP1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted16/01/201416/01/2014Confirmatory389569904
1645857USP28 deubiquitinase inhibition: Primary qHTSUSP28Ubiquitin carboxyl-terminal hydrolase 28USP28nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other474801413
1645860USP30 deubiquitinase inhibition: Primary qHTSUSP30Ubiquitin carboxyl-terminal hydrolase 30USP30nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other474802500
1321Primary Cell-based High Throughput Screening Assay for Inhibitors of Wee1 DegradationWEE1Wee1-like protein kinaseWEE1nonProligerativenervousSystemneurodegenerationtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/06/200815/06/2010Screening2179592616
880qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore)GNAI1Guanine nucleotide-binding protein GGNAI1nonProligerativenervousSystemNeurodevelopmental disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/12/200705/08/2009Confirmatory2298881007
504333qHTS Assay for Inhibitors of BAZ2BBAZ2BBromodomain adjacent to zinc finger domain protein 2BBAZ2B_modulatorsnonProligerativenervousSystemneurodevelopmentalDisordersalphaScreentargetBasedphenotypeID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/02/201122/02/2011Confirmatory35682615709
2073Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) AssayCACNA1BVoltage-dependent N-type calcium channel subunit alpha-1DCACNA1B_modulatorsnonProligerativenervousSystempainPPI_FRETtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/10/200908/10/2010Confirmatory292323567
652010Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1NR0B1Nuclear receptor subfamily 0 group B member 1NR0B1nonProligerativenervousSystempalsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/02/201301/02/2013Screening3689274094
504766Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1)NR0B1Nuclear receptor subfamily 0 group B member 1NR0B1nonProligerativenervousSystempalsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted18/05/201120/06/2011Screening3434683417
624125Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4Muscarinic acetylcholine receptor M4CHRM4_antgonistsnonProligerativenervousSystemparkinson[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/201211/09/2013Screening3638032629
504660Allosteric Agonists of the Human D1 Dopamine Receptor: qHTSDRD1Dopaminereceptor1D1_activatorsnonProligerativenervousSystemparkinson[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/04/201113/04/2011Screening3613303713
624465Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: AgonistsDRD2Dopaminereceptor2D2_agonistsnonProligerativenervousSystemparkinsonbetaArrestinLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/08/201207/08/2012Other359518300
485358HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for AgonistsDRD2Dopaminereceptor2D2_agonistsnonProligerativenervousSystemparkinson[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/10/201005/10/2010Screening3356521779
624464Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: PotentiatorsDRD2Dopaminereceptor2D2_PAMsnonProligerativenervousSystemparkinsonbetaArrestinLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/08/201207/08/2012Other357537806
485347HTS Assay for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Primary Screen for PotentiatorsDRD2Dopaminereceptor2D2_PAMsnonProligerativenervousSystemparkinson[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201005/10/2010Screening3398871178
1813MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitorsaSynucleinExpressionInhibitorsnonProligerativenervousSystemPDexpressionReporterLumiphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/06/200914/12/2009Screening3038012498
641Allosteric Modulators of D1 Receptors: Primary ScreenDRD1Dopamine receptor D1D1nonProligerativenervousSystemPDcAMP_reportertargetBasedassayID3virtual screening, assayID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletednotApplicablecompletednotStartednotStarted02/04/200716/11/2007Screening577053413
624466Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1)TAAR1Trace amine-associated receptor 1TAAR1nonProligerativenervousSystemPD[Ca++]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/08/201216/08/2012Screening3625775374
624127Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4Muscarinic acetylcholine receptor M4CHRM4_agonistsnonProligerativenervousSystempsychosis[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/201209/05/2012Screening363803502
504652Antagonist of Human D 1 Dopamine Receptor: qHTSDRD1Dopaminereceptor1D1_inhibitorsnonProligerativenervousSystempsychosis[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/04/201112/04/2011Screening35580511440
624463Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: AntagonistsDRD2Dopaminereceptor2D2_antagonistsnonProligerativenervousSystempsychosisbetaArrestinLumitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/08/201207/08/2012Other3622741056
485344HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for AntagonistsDRD2Dopaminereceptor2D2_antagonistsnonProligerativenervousSystempsychosis[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/10/201004/10/2010Screening3363086862
2156Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channelsKCNQ2Potassium voltage-gated channel subfamily KQT member 2KCNQ2nonProligerativenervousSystemRare genetic epilepsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/11/200930/03/2010Screening3056093405
2239Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channelsKCNQ2Potassium voltage-gated channel subfamily KQT member 2KCNQ2nonProligerativenervousSystemRare genetic epilepsytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/01/201030/03/2010Screening3056001644
1745845Primary qHTS for Inhibitors of ATXN expressionATXN2Ataxin-2ATXN2_repressorsnonProligerativenervousSystemspinocerebellarAtaxiareporterLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/04/202201/02/2023Confirmatory3584342554
1347120qHTS for Suppressors of FUS Proteinopathy: Primary screen using FUS-linked yeast assayFUSRNA-binding protein FUSFUS_asupressorsnonProligerativenervousSystemsporadic amyotrophic lateral sclerosistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/09/201907/09/2019Confirmatory385746932
778CYP2C19 AssayCYP2C19Cytochrome P450 2C19CYP2C19_inhibitorsnonProligerativenotSpecifiednotSpecifiedenzymeActLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/07/200727/08/2010Screening9585720295
777CYP2C9 AssayCYP2C9Cytochrome P450 2C9CYP2C9_inhibitorsnonProligerativenotSpecifiednotSpecifiedenzymeActLucitargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/07/200727/08/2010Screening9585818730
2099Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 ActivityKDM4CKDM4CnonProligerativeotherPhenotypesage at menarchetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/11/200905/11/2009Screening326066228
1861Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7).NPBWR1Neuropeptide B/W receptor 1, Neuropeptides B/W receptor type 1NPBWR1nonProligerativeotherPhenotypesage at menarchetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/07/200920/07/2009Screening2907263127
1441Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao.RGS16Regulator of G-protein signaling 16RGS16nonProligerativeotherPhenotypescircadian rhythmtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/12/200801/12/2008Screening218528826
1461qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal TransductionNPSR1Neuropeptide S receptorNPSR1nonProligerativepsychiatricDisorderanxietycAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/12/200810/06/2009Confirmatory2208622309
1040Primary cell-based high-throughput screening assay for antagonists of NPY-Y1NPY1RNeuropeptide Y receptor type 1NPY1RnonProligerativepsychiatricDisorderanxietycAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/02/200816/06/2010Screening1961761984
493056qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for EnhancersTRHRThyrotropin-releasing hormone receptorTRHRnonProligerativepsychiatricDisorderanxiety[Ca++]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/01/201120/01/2011Screening3613302424
651719Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3)GALR3Galanin receptor type 3GALR3_antagonistsnonProligerativepsychiatricDisorderanxietycAMP-coupled CNG channel: MPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201229/10/2012Screening3578591562
504803Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1)HTRA1HTRA1 proteinHTRA1nonProligerativepsychiatricDisordercerebral arteriopathy with subcortical infarcts and leukoencephalopathytargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/06/201108/06/2011Screening3434671710
574Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E)HTR1E5-hydroxytryptamine receptor 1EHTR1EnonProligerativepsychiatricDisordercognitive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/01/200706/11/2007Screening64908446
571Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E)HTR1E5-hydroxytryptamine receptor 1EHTR1EnonProligerativepsychiatricDisordercognitive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/01/200701/11/2007Screening64908641
463165Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4)RGS4Regulator of G-protein signaling 4RGS4nonProligerativepsychiatricDisordercognitive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/08/201027/08/2010Screening3056101365
463111Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4)RGS4Regulator of G-protein signaling 4RGS4nonProligerativepsychiatricDisordercognitive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/08/201019/08/2010Screening3056102820
624169Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)HTR2A5-hydroxytryptamine receptor 2AHTR2AnonProligerativepsychiatricDisorderdevelopmental disorder of mental healthtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/201222/05/2012Screening3638032412
449768High Throughput Screening for Cocaine Antagonists: Primary ScreenSLC6A3Sodium-dependent dopamine transporterSLC6A3nonProligerativepsychiatricDisorderdrug addictionuptaketargetBasedassayID2prospective analytics successfulnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/07/201023/07/2010Screening1082861415
434989Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1)HCRTR1Orexin/Hypocretin receptor type 1HCRTR1nonProligerativepsychiatricDisorderinsomniatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/06/201015/06/2010Screening3260241387
567Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonistsHTR1A5-hydroxytryptamine receptor 1AHTR1AnonProligerativepsychiatricDisordermajor depressive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/12/200611/04/2007Screening64908366
612Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonistsHTR1A5-hydroxytryptamine receptor 1AHTR1AnonProligerativepsychiatricDisordermajor depressive disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/03/200711/04/2007Screening61606416
488969Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary ScreeningGRM8Glutamate metabotropic receptor 8, Glutamate receptor, metabotropic 8, isoform CRA_a, Metabotropic glutamate receptor 8GRM8nonProligerativepsychiatricDisordermental or behavioural disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201024/03/2012Screening1051512166
2650Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alphaGSK3AGlycogen synthase kinase-3 alphaGSK3AnonProligerativepsychiatricDisordermental or behavioural disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/03/201031/03/2010Screening315412318
1457qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with LithiumIMPA1Inositol monophosphatase 1IMPA1nonProligerativepsychiatricDisordermental or behavioural disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/12/200823/12/2008Confirmatory205582727
1347165Primary screen for KDM5B Histone Demethylases FDH-coupled qHTSKDM5B[histone H3]-trimethyl-L-lysine, Lysine-specific demethylase 5BKDM5BnonProligerativepsychiatricDisordermental or behavioural disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/12/201906/12/2019Confirmatory2178195697
2435Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR).OXTROxytocin receptorOXTRnonProligerativepsychiatricDisordermental or behavioural disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/02/201015/06/2010Screening3247471043
1304Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1NPY1RNeuropeptide Y receptor type 1NPY1RnonProligerativepsychiatricDisordermental processtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted30/05/200816/06/2010Screening217959798
720711qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screenRAPGEF4Rap guanine nucleotide exchange factor 4RAPGEF4nonProligerativepsychiatricDisordermental processtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201331/10/2013Confirmatory364614290
720708qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screenRAPGEF4Rap guanine nucleotide exchange factor 4RAPGEF4nonProligerativepsychiatricDisordermental processtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/10/201331/10/2013Confirmatory364614663
492972Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3)PAFAH1B3Platelet-activating factor acetylhydrolase IB subunit alpha1PAFAH1B3nonProligerativepsychiatricDisorderpervasive developmental disordertargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/12/201008/12/2010Screening335239928
624467Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1)TAAR1Trace amine-associated receptor 1TAAR1nonProligerativepsychiatricDisorderschizophrenia[Ca++]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/08/201208/08/2012Screening3625773573
743398Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_ActivityWnt/Beta-catenin pathwaynonProligerativepsychiatricDisorderschizophreniaexpressionReporterphenotypicTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/04/201408/04/2014Screening3042183630
504692Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A)HTR5A5-hydroxytryptamine receptor 5AHTR5AnonProligerativepsychiatricDisorderschizophreniatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/04/201101/07/2011Screening3352392035
504634Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A)HTR5A5-hydroxytryptamine receptor 5AHTR5AnonProligerativepsychiatricDisorderschizophreniatargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/04/201103/04/2011Screening335239279
720553qHTS for Inhibitors of KCHN2 3.1: Mutant qHTSKCNH2Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2KCNH2nonProligerativepsychiatricDisorderschizophrenia[Tl+]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/07/201331/07/2013Confirmatory3420843260
624288qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTSGNASGuanine nucleotide-binding protein GGNASnonProligerativerareDiseasesMcCune-Albright syndrome (MAS)cAMPtargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/06/201212/06/2012Confirmatory3374461356
485313qHTS Assay for NPC1 Promoter ActivatorsNPC1NPC intracellular cholesterol transporter 1NPC1nonProligerativerareDiseasesNiemann Pick Type C (NPC)expressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/09/201004/10/2010Confirmatory3206827575
485297qHTS Assay for Rab9 Promoter ActivatorsRAB9ARas-related protein Rab-9ARAB9AnonProligerativerareDiseasesNiemann Pick Type C (NPC)expressionReporterphenotypic&targetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted29/09/201029/09/2010Confirmatory3206039133
720511Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_SinglePoint_HTS_ActivityCFTRCystic fibrosis transmembrane conductance regulatorcftrCorrectorsnonProligerativerareDiseasescysticFibrosisIodineEntry_YFPtargetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway16/07/201316/07/2013Screening3437861253
602252Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_ActivityCFTRCystic fibrosis transmembrane conductance regulatorcftrTrafficModulatorsnonProligerativerareDiseasescysticFibrosisPPI_FPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted10/02/201210/02/2012Screening2965012737
588850uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assayNFKB1Cystic fibrosis transmembrane conductance regulatorNFKB1nonProligerativerareDiseasescysticFibrosisnfkbExpressionReporterGFPtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/12/201105/12/2011Screening3592443094
624291qHTS for Activators of Integrin-Mediated Alleviation for Muscular DystrophyCGAGlycoprotein hormones alpha chainCGA_integrin_activatorsnonProligerativerareDiseasesmuscularDistrophyexpressionReportertargetBasedTID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/06/201213/06/2012Confirmatory345855222
1458qHTS Assay for Enhancers of SMN2 Splice Variant ExpressionSMN1; SMN2Survival motor neuron proteinSMN1; SMN2nonProligerativerareDiseasesSMAexpressionReporterphenotypic&targetBasedTID3virtual screening, targetID, pathway analysis and repurposing completedcompletedcompletedcompletedcompletedcompletedcompletedunderwayunderway23/12/200823/12/2008Confirmatory2084895817
1422Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary ScreenPTGER2Prostaglandin E2 receptor EP2 subtypePTGER2nonProligerativereproductiveSystemmale reproductive system diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted31/10/200831/10/2008Screening2501901304
940Modulators of the EP2 prostaglandin E2 receptor - Primary ScreeningPTGER2Prostaglandin E2 receptor EP2 subtypePTGER2nonProligerativereproductiveSystemmale reproductive system diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/12/200730/10/2008Screening2555372141
624267Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2)RIPK2Receptor-interacting serine/threonine-protein kinase 2RIPK2nonProligerativereproductiveSystemmale reproductive system diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/06/201214/06/2012Screening3638031383
1565uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1PHOSPHO1Phosphoethanolamine/phosphocholine phosphatasePHOSPHO1nonProligerativereproductiveSystemsex hormone-binding globulin measurementtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/03/200930/12/2010Confirmatory2883213164
588590qHTS for Inhibitors of Polymerase IotaPOLIDNA polymerase iotaPOLInonProligerativerespiratorylower respiratory tract diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/10/201120/10/2011Confirmatory3860633989
624137SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_ActivityID4DNA-binding protein inhibitor ID-4ID4nonProligerativerespiratorypulmonary function measurementtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted09/05/201209/05/2012Screening31324362
2006uHTS HTRF assay for identification of inhibitors of SUMOylationUBE2ISUMO-conjugating enzyme UBC9UBE2InonProligerativerespiratoryrespiratory system diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/10/200913/01/2011Confirmatory2909151039
623877Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A)ANO1Anoctamin-1ANO1_activatorsnonProligerativerespiratorypulmonary arterial hypertension[Cl-]itargetBasedassayID1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/03/201227/03/2012Screening3351801022
628Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary ScreenCHRM1Muscarinic acetylcholine receptor M1CHRM1_allosteric_antagonistsnonProligerativerespiratoryrespiratoryDisorders[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/03/200729/10/2010Screening636562179
588852Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1)CHRM1Muscarinic acetylcholine receptor M1CHRM1_antgonistsnonProligerativerespiratoryrespiratoryDisorders[Ca++]itargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/12/201109/05/2012Screening3592074555
775Screen for Chemicals that Extend Yeast LifespanlifespannonProligerativeagingsenescenceyeastDeathReversionphenotypic1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/07/200716/11/2007Screening132777904
2550High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6)TRPC6Short transient receptor potential channel 6TRPC6nonProligerativeurinarySystemfocal segmental glomerulosclerosistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201025/10/2010Screening305610382
2553High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6)TRPC6Short transient receptor potential channel 6TRPC6nonProligerativeurinarySystemfocal segmental glomerulosclerosistargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201021/03/2010Screening3056103253
1918High throughput discovery of novel modulators of ROMK K+ channel activity: Primary ScreenKCNJ1ATP-sensitive inward rectifier potassium channel 1 , cDNA FLJ76032, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1KCNJ1nonProligerativeurinarySystemrenal tubular transport diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/09/200904/12/2009Screening1252682463
485281qHTS Assay for Identification of Novel General AnestheticsFTLFerritin light chainFTLnonProligerativevisualSystemeye diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/09/201027/09/2010Confirmatory341499255
360GlucocerebrosidaseGBA1Lysosomal acid glucosylceramidaseGBA1nonProligerativevisualSystemeye diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/01/200618/02/2007Confirmatory48118549
2071Colorimetric Assay for Inhibitors for NALP1NLRP1NACHT, LRR and PYD domains-containing protein 1NLRP1nonProligerativevisualSystemeye diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/10/200913/01/2011Screening2800241717
604Primary biochemical high-throughput screening assay for inhibitors of Rho kinase 2 (Rhok2)ROCK2Rho-associated protein kinase 2ROCK2nonProligerativevisualSystemeye diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/02/200711/04/2007Screening59788212
488977Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT)SLC5A7High affinity choline transporter 1SLC5A7nonProligerativevisualSystemeye diseasetargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted01/11/201014/12/2010Screening3065021509
2101qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher DiseaseGBAGlucosylceramidase , Lysosomal acid glucosylceramidaseGBAUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/11/200905/11/2009Confirmatory321552295
2280Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction.GLD-1Female germline-specific tumor suppressor gld-1GLD-1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted21/01/201010/05/2011Screening3247461419
651636uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assayGPR183G-protein coupled receptor 183GPR183UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201212/10/2012Screening3638402946
602179qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTSHEL-S-26Isocitrate dehydrogenase [NADP] , Isocitrate dehydrogenase [NADP] cytoplasmicHEL-S-26UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/01/201205/04/2012Confirmatory387604365
493160uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1)HKDC1Hexokinase HKDC1HKDC1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/02/201108/02/2011Screening340696540
624168uHTS identification of small molecule activators of alpha dystroglycan glycosylationLARGEGlycosyltransferase-like protein isoform A , Xylosyl- and glucuronyltransferase LARGE1LARGEUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted22/05/201222/05/2012Screening363840805
2016Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN.MEP2Ammonium transporter MEP2MEP2UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/200905/04/2011Screening3266511682
1832MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary ScreenMEX-5Zinc finger protein mex-5MEX-5UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/06/200929/09/2009Screening3017881137
588627Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signalingMGRG2Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1MGRG2UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/10/201124/10/2011Screening3065021351
588675Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signalingMGRG2Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1MGRG2UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201125/10/2011Screening3065021932
588676Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signalingMGRG2Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1MGRG2UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/10/201125/10/2011Screening3065023868
651718Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA)MSRAMitochondrial peptide methionine sulfoxide reductase , peptide-methionineMSRAUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/201229/10/2012Screening3625772709
588352Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)NCOA3Nuclear receptor coactivator 3NCOA3UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/09/201131/10/2011Screening359207620
1578uHTS luminescence assay for the identification of compounds that inhibit NOD1NOD1Nucleotide-binding oligomerization domain-containing protein 1NOD1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/03/200930/12/2010Confirmatory2894222997
602438uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assayNRP1Neuropilin-1NRP1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted20/03/201220/03/2012Screening3638403086
1645870Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo AssayNTMT1N-terminal Xaa-Pro-Lys N-methyltransferase 1NTMT1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted27/05/202127/05/2021Confirmatory564401336
624263A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 ExpressionPARK2E3 ubiquitin-protein ligase parkinPARK2UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted05/06/201205/06/2012Confirmatory406283823
1987Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5).PPP5CSerine/threonine-protein phosphatase 5PPP5CUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/10/200915/06/2010Screening314999564
2417High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar CompartmentPTBP1Polypyrimidine tract-binding protein 1PTBP1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/02/201024/02/2010Screening1397184338
521HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia TargetPTPN7Tyrosine-protein phosphatase non-receptor type 7PTPN7UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/11/200630/08/2010Confirmatory112381724
760HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtypeRAB2ARas-related protein Rab-2ARAB2AUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted06/07/200725/10/2009Screening194628365
1515Primary biochemical high throughput screening assay to identify inhibitors of Retinoblastoma binding protein 9 (RBBP9)RBBP9Serine hydrolase RBBP9RBBP9UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/02/200916/06/2010Screening217959445
2025Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN.RPL19BLarge ribosomal subunit protein eL19RPL19BUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted26/10/200905/04/2011Screening325372982
588493uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assayRPN1126S proteasome non-ATPase regulatory subunit 14 , Testis tissue sperm-binding protein Li 69nRPN11UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted12/10/201125/02/2012Screening3592442134
1509Primary Cell-Based Assay to Identify Agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4)S1PR4Sphingosine 1-phosphate receptor 4S1PR4UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/01/200916/06/2010Screening217959771
1510Primary Cell-Based Assay to Identify Antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4)S1PR4Sphingosine 1-phosphate receptor 4S1PR4UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/01/200916/06/2010Screening217959569
504775HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_ActivitySCARB1Scavenger receptor class B member 1SCARB1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted25/05/201125/05/2011Screening316970306
817Identification and characterization of compounds for addressing human bone marrow failureSDO1Ribosome maturation protein SDO1SDO1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/10/200703/10/2007Other138737298
434973uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7)SENP7Sentrin-specific protease 7 , SUMO specific peptidase 7SENP7UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/06/201014/01/2011Screening3316704902
652115MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrialSIRT5UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted15/03/201315/03/2013Screening3235073752
624304uHTS identification of SKN-1 Inhibitors in a fluoresence assaySKN-1Protein skinhead-1SKN-1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted19/06/201215/03/2013Screening3638401794
540253qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociationSNUPNSnurportin-1SNUPNUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted14/07/201114/07/2011Confirmatory340719242
2330Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33STK33cDNA FLJ35401 fis, clone SKNSH2005792, highly similar to Serine/threonine-protein kinase 33 , Serine/threonine kinase 33, Serine/threonine kinase 33 , Serine/threonine-protein kinase 33STK33UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/02/201003/02/2010Screening373412812
2661Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 ActivitySTK33Serine/threonine-protein kinase 33STK33UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/03/201024/03/2010Screening321808235
463195uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assayTIM10Mitochondrial import inner membrane translocase subunit TIM10TIM10UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted03/09/201025/10/2010Screening3316714615
463190uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assayTIM10Mitochondrial import inner membrane translocase subunit TIM10TIM10UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted02/09/201007/09/2010Screening3316717319
463212uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assayTIM23Mitochondrial import inner membrane translocase subunit TIM23TIM23UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted07/09/201007/09/2010Screening3316714405
1443uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cellsTNFSF10Tumor necrosis factor ligand superfamily member 10TNFSF10UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted08/12/200804/01/2011Screening217035883
2227Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4)TRPC4Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4TRPC4UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted28/12/200930/03/2010Screening3056001291
2237Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4).TRPC4Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4TRPC4UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted11/01/201030/03/2010Screening3056001510
2247Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4).TRPC4Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4TRPC4UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted13/01/201030/03/2010Screening3040011189
1424Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1)TRPN1Ion channel NompCTRPN1UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/11/200804/11/2008Screening217959390
485273uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET AssayUBE2NUbiquitin-conjugating enzyme E2 NUBE2NUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted24/09/201004/10/2010Screening3303931538
1645856USP10 deubiquitinase inhibition: Primary qHTSUSP10Ubiquitin carboxyl-terminal hydrolase 10USP10UntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted04/05/202101/07/2021Other47480509
781uHTS for 14-3-3/Bad interaction inhibitorsYWHAZ14-3-3 protein zeta/deltaYWHAZUntaggedtargetBased1records allow Machine LearningnotStartednotStartednotStartednotStartednotStartednotStartednotStartednotStarted23/07/200723/07/2007Screening2173321549