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AID | BioAssay Name | gene | protName | program | programCategory | area | disease | assayType | assayMode | addTasks | level | tractability | PoC | MLmodels | virtualScreening | TID/assayID | pathwaysAnalysis | graphsGeneration | literatureCheck | webPublication | Deposit Date | Modify Date | Outcome Type | Number of Tested CIDs | Number of Active CIDs |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
720647 | Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition | LGR2 | Leucine-rich repeat-containing G-protein-coupled receptor 2 | hyphantria cunea | antiInfective | antiArthropodal | hyphantria cunea | cAMP | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/10/2013 | 15/01/2015 | Screening | 375648 | 1337 |
11 gram + & - bacterial strains at ChEMBL | antibacterial | antiInfective | antibacterial | 11_bacterialStrains | cellDeath | phenotypic | TID | 3 | virtual screening, targetID and repurposing completed | completed | completed | completed | underway | notStarted | underway | notStarted | notStarted | ||||||||
492967 | A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis | CapD | polysaccharide biosynthesis protein | Bacillus anthracis | antiInfective | antibacterial | anthrax | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/12/2010 | 19/10/2016 | Other | 138854 | 320 |
912 | qHTS Assay for Anthrax Lethal Toxin Internalization | Bacillus anthracis Lethal Toxin Internalization | antiInfective | antibacterial | anthrax | toxinInternalization | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/12/2007 | 12/07/2010 | Confirmatory | 68961 | 466 | ||
588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | P15917 | Lethal Factor Protease | Bacillus anthracis Lethal factor inhibitors | antiInfective | antibacterial | anthrax | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2011 | 13/10/2011 | Screening | 354794 | 422 |
several TB strains | TB | antiInfective | antibacterial | antibacterials | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | ||||||||
1490 | qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) | FFP | 4'-phosphopantetheinyl transferase ffp | Bacillus subtilis | antiInfective | antibacterial | B. subtilis | enzymeAct | targetBased | phenotypeID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 08/01/2009 | 26/01/2010 | Confirmatory | 306599 | 10840 |
651965 | qHTS Assay for Activators of ClpP | CLPP | ATP-dependent Clp protease proteolytic subunit | Bacillus subtilis (strain 168) | antiInfective | antibacterial | B. subtilis | enzymeAct | targetBased | phenotypeID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 03/01/2013 | 03/01/2013 | Confirmatory | 338378 | 6439 |
588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | BOTA | Botulinum neurotoxin type A | Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) | antiInfective | antibacterial | botulism | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2011 | 14/11/2011 | Screening | 354794 | 609 |
588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | BoNT/F | botulinum neurotoxin type F | Clostridium botulinum toxin inhibitors | antiInfective | antibacterial | botulism | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2011 | 13/10/2011 | Screening | 354794 | 780 |
652162 | C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_Activity | ToxB | TcdB glycohydrolase | TcdB glycohydrolaseInhibitors | antiInfective | antibacterial | C. difficile | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/03/2013 | 27/03/2013 | Screening | 349124 | 837 | |
602405 | PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity | WLAI | PglD | Campylobacter jejuni | antiInfective | antibacterial | Campylobacter jejuni | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2012 | 15/03/2012 | Screening | 355889 | 350 |
504770 | A screen for compounds that inhibit replication of Vibrio cholerae chromosome II | AAF95916 | Uncharacterized protein | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) | antiInfective | antibacterial | cholera | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/05/2011 | 19/10/2016 | Other | 132441 | 351 |
588436 | Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity | Vibrio cholerae BH1578 strain | antiInfective | antibacterial | cholera | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2011 | 04/10/2011 | Screening | 349947 | 553 | ||
1217 | uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays | DLD | Dihydrolipoyl dehydrogenase , Dihydrolipoyl dehydrogenase, mitochondrial | DiaphoraseInhibitors | antiInfective | antibacterial | Clostridium kluyveri | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/03/2008 | 29/09/2010 | Screening | 194152 | 1342 | |
1053175 | A screen for compounds that inhibit growth of Escherichia coli | Escherichia coli | antiInfective | antibacterial | E. coli | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 26/06/2014 | 17/10/2016 | Other | 327980 | 699 | ||
651602 | Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) | RECD | RecBCD enzyme subunit RecD | Escherichia coli (strain K12) | antiInfective | antibacterial | E. coli | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2012 | 27/09/2012 | Screening | 362577 | 949 |
602123 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon) | LON | Lon protease | Escherichia coli (strain K12) | antiInfective | antibacterial | E. coli | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/12/2011 | 10/12/2011 | Screening | 362020 | 1524 |
585 | Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) | AMPC | Beta-lactamase | Escherichia coli (strain K12) | antiInfective | antibacterial | E. coli | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/02/2007 | 30/04/2007 | Confirmatory | 69668 | 1256 |
485341 | qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) | AMPC | Beta-lactamase | Escherichia coli (strain K12) | antiInfective | antibacterial | E. coli | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2010 | 04/10/2010 | Confirmatory | 330677 | 1730 |
504720 | uHTS identification of MazEF TA System activators via a fluorescence-based single-stranded RNase assay | MAZF | Endoribonuclease toxin MazF | Escherichia coli (strain K12) | antiInfective | antibacterial | E. coli | toxinAntitoxin-RNAseActivity | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/05/2011 | 05/05/2011 | Screening | 348923 | 1104 |
2315 | A qHTS for Small Molecule Inhibitors of Shiga Toxin | STX1 | rRNA N-glycosylase | Escherichia coli O157:H7 | antiInfective | antibacterial | E. coli | proteinSynthesis | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/02/2010 | 04/02/2010 | Screening | 292805 | 26874 |
2314 | Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin | STX1 | rRNA N-glycosylase | Escherichia coli O157:H7 | antiInfective | antibacterial | E. coli | proteinSynthesis | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/02/2010 | 04/02/2010 | Screening | 295619 | 37013 |
720706 | HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_Activity | Escherichia coli ribosomal RNAs | antiInfective | antibacterial | E. coli | GFP fluorescence | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 05/03/2014 | Screening | 348128 | 5500 | ||
573 | Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS | Escherichia coli ?tolC mutations | antiInfective | antibacterial | E. coli | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 04/01/2007 | 04/05/2007 | Screening | 65096 | 1420 | ||
1066 | High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary Screen | MVAE | Acetyl-CoA acetyltransferase | Enterococcus faecalis (Streptococcus faecalis) | antiInfective | antibacterial | Enterococcus faecalis | enzymeAct | targetBased | phenotypeID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 03/03/2008 | 14/03/2008 | Screening | 194344 | 792 |
361 | Pyruvate Kinase | PYK | Pyruvate kinase | Geobacillus stearothermophilus (Bacillus stearothermophilus) | antiInfective | antibacterial | Geobacillus stearothermophilus | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/01/2006 | 31/10/2006 | Confirmatory | 51415 | 602 |
435030 | Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex | AddAB | Helicobacter pylori | antiInfective | antibacterial | H. pylori | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/07/2010 | 26/10/2010 | Screening | 326024 | 935 | |
449728 | Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability | Helicobacter pylori | antiInfective | antibacterial | H. pylori | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/07/2010 | 27/10/2010 | Screening | 326024 | 893 | ||
1272365 | SSB-PriA antibiotic resistant target AlphaScreen | SSB | single-stranded DNA binding protein | Klebsiella pneumonia SSB-PriA interaction | antiInfective | antibacterial | K. pneumonia | protProtInteraction | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/09/2018 | 22/08/2023 | Screening | 431236 | 2568 |
1020 | Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay | ZWF | Glucose-6-phosphate 1-dehydrogenase | Leuconostoc mesenteroides | antiInfective | antibacterial | Leuconostoc mesenteroides | counterScreen | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/01/2008 | 24/09/2010 | Screening | 195560 | 236 |
2094 | Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System | LUXP | Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi (Beneckea harveyi) | antiInfective | antibacterial | luminous vibriosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/11/2009 | 04/11/2009 | Screening | 302177 | 1222 |
1556 | Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase | BLAIMP-1 | Beta-lactamase | Pseudomonas aeruginosa | antiInfective | antibacterial | P. aeruginosa | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/03/2009 | 04/01/2013 | Screening | 290726 | 1322 |
488965 | Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_Activity | PvdQ | PvdQ acylase | Pseudomonas aeruginosa | antiInfective | antibacterial | P. aeruginosa | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/10/2010 | 30/11/2010 | Screening | 337500 | 213 |
1527 | Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase | BLAVIM-2 | Metallo-beta-lactamase type 2 | Pseudomonas aeruginosa | antiInfective | antibacterial | P. aeruginosa | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/02/2009 | 26/12/2012 | Screening | 290726 | 2575 |
504884 | Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_Activity | SUPX | DNA topoisomerase 1 | Yersinia pestis | antiInfective | antibacterial | plague | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/06/2011 | 18/10/2011 | Screening | 356253 | 229 |
898 | YopH HTS | YopH | Yersinia outer protein H | Yersinia pestis | antiInfective | antibacterial | plague | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2007 | 18/12/2007 | Screening | 139929 | 223 |
602399 | uHTS identification of inhibitors of NadD in a Colorimetric assay | NaMNAT | nicotinic acid mononucleotide adenylyltransferase | NadD_inhibitors | antiInfective | antibacterial | S. aureus | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2012 | 20/06/2012 | Screening | 362063 | 2815 | |
463173 | A screen for compounds that inhibit cell wall-associated teichoic acid synthesis in Staphylococcus aureus | Staphylococcus aureus | antiInfective | antibacterial | S. aureus | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 30/08/2010 | 19/10/2016 | Screening | 51739 | 4434 | ||
720641 | A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus | LtaS | Lipoteichoic acid (LTA) synthase | Staphylococcus aureus | antiInfective | antibacterial | S. aureus | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/09/2013 | 02/11/2016 | Other | 168223 | 878 |
1259311 | A screen for compounds that are lethal to S. aureus RN4220 | Staphylococcus aureus RN4220 | antiInfective | antibacterial | S. aureus | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 17/04/2017 | 17/04/2017 | Other | 327980 | 1062 | ||
1259309 | A screen for compounds that are lethal to S. aureus RN4220 with the processive glycosyltransferase UgtP deleted | Staphylococcus aureus RN4220 | antiInfective | antibacterial | S. aureus | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 17/04/2017 | 17/04/2017 | Other | 327980 | 1782 | ||
555 | Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK | MK | mevalonate kinase | Streptococcus Pneumoniae | antiInfective | antibacterial | S. Pneumoniae | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/12/2006 | 09/04/2007 | Screening | 65241 | 316 |
556 | Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC | MVAD | diphosphomevalonate decarboxylase | Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | antiInfective | antibacterial | S. Pneumoniae | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/12/2006 | 09/04/2007 | Screening | 65385 | 320 |
539 | Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - PMK | MVAK2 | phosphomevalonate kinase | Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) | antiInfective | antibacterial | S. Pneumoniae | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/11/2006 | 09/04/2007 | Screening | 65392 | 319 |
1662 | MLPCN Streptokinase Expression Inhibition | SKA | Streptokinase A | Streptococcus pyogenes serotype M1 | antiInfective | antibacterial | S. Pneumoniae | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/04/2009 | 09/04/2009 | Screening | 303477 | 3959 |
1863 | A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium | PhoB/PhoR | PhoP regulon | Salmonella Typhi | antiInfective | antibacterial | salmonellosis | GFP reporter | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2009 | 22/02/2010 | Confirmatory | 300458 | 474 |
1850 | A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi | PhoB/PhoR | PhoP regulon | Salmonella Typhimurium | antiInfective | antibacterial | salmonellosis | GFP reporter | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/07/2009 | 17/02/2010 | Confirmatory | 305999 | 1018 |
1159583 | High throughput screen for small molecule inhibitors of a hypoxia-regulated fluorescent biosensor in Mycobacterium tuberculosis | Mycobacterium Tuberculosis | antiInfective | antibacterial | tuberculosis | GFP reporter | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 08/01/2016 | 17/10/2016 | Other | 300060 | 312 | ||
449762 | High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media | Mycobacterium Tuberculosis | antiInfective | antibacterial | tuberculosis | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 22/07/2010 | 23/07/2010 | Confirmatory | 327558 | 1938 | ||
540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | MENB | 1,4-dihydroxy-2-naphthoyl-CoA synthase | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/07/2011 | 18/10/2016 | Other | 102628 | 440 |
2221 | Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity | RECA | Protein RecA | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | antiInfective | antibacterial | tuberculosis | GFP fluorescence | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2009 | 08/06/2010 | Screening | 293376 | 2191 |
588726 | Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis | FBA | Fructose-bisphosphate aldolase | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/10/2011 | 02/08/2012 | Screening | 359207 | 8215 |
1376 | Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU) | GLMU | Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/08/2008 | 28/06/2010 | Confirmatory | 215860 | 533 |
493033 | A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtI | MBTI | Salicylate synthase | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/01/2011 | 19/10/2016 | Other | 104192 | 927 |
1949 | High Throughput Screen of 100,000 compound library to Identify Inhibitors of Mycobacterium tuberculosis H37Rv | Mycobacterium tuberculosis H37Rv | antiInfective | antibacterial | tuberculosis | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 18/09/2009 | 13/10/2009 | Confirmatory | 100685 | 1594 | ||
1626 | High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv | Mycobacterium tuberculosis H37Rv | antiInfective | antibacterial | tuberculosis | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 26/03/2009 | 02/10/2009 | Confirmatory | 215098 | 2044 | ||
434955 | Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics | Mycobacterium Tuberculosis sensitization to betaLactam | antiInfective | antibacterial | tuberculosis | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/05/2010 | 28/07/2010 | Confirmatory | 327901 | 876 | ||
488890 | Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis | Mycobacterium tuberculosis, non-replicating, drug-tolerant | antiInfective | antibacterial | tuberculosis | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 25/10/2010 | 02/12/2010 | Confirmatory | 324433 | 1277 | ||
588549 | Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_Activity | FadD28 | fatty acyl-AMP ligase | Mycobacterium tuberculosis | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/10/2011 | 18/10/2011 | Screening | 355054 | 777 |
602481 | Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity | BioA | 7,8-Diaminopelargonic acid synthase | Mycobacterium tuberculosis | antiInfective | antibacterial | tuberculosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/03/2012 | 24/03/2012 | Screening | 353572 | 342 |
1532 | Rml C and D inhibition 384-well mixture HTS | RmlC_inhibitors | antiInfective | antibacterial | tuberculosis | enzymeActFlint | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/03/2009 | 03/03/2009 | Screening | 106271 | 417 | |||
504577 | HTS of Small Molecules that Regulate V-ATPase Proton Transport in Yeast using pHLuorin | VMA11 | V-type proton ATPase subunit c' | VMA11 | antiInfective | antifungal | antifungal | pHSensitiveDye | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/03/2011 | 18/01/2012 | Screening | 345985 | 1287 |
1962 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). | TPT1 | TPT1 | antiInfective | antifungal | antifungal | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/09/2009 | 16/06/2010 | Screening | 302663 | 2452 | |
540336 | Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity | RTT109 | Histone acetyltransferase RTT109 | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | antiInfective | antifungal | candidiasis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/08/2011 | 09/08/2011 | Screening | 328088 | 521 |
1979 | Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound | HSP90 | Heat shock protein 90 homolog | fluconazole-resistant C.albicans | antiInfective | antifungal | candidiasis | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/10/2009 | 14/10/2009 | Screening | 302451 | 1736 |
485275 | Phenotypic HTS multiplex for antifungal efflux pump inhibitors | antifungal efflux pumps inhibitors | antiInfective | antifungal | fungsusGeneral | transportFLINT | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2010 | 09/03/2012 | Screening | 328897 | 1437 | ||
652067 | Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) | DAF-12 | Nuclear hormone receptor family member daf-12 | DAF-12_activators | antiInfective | antihelminthic | H. contortus | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/02/2013 | 25/06/2013 | Screening | 369953 | 5353 | |
687014 | Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). | DAF-12 | Nuclear hormone receptor family member daf-12 | DAF-12_activators | antiInfective | antihelminthic | H. glycines | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/05/2013 | 31/05/2013 | Screening | 369953 | 6837 | |
652126 | Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) | DAF-12 | Nuclear hormone receptor family member daf-12 | DAF-12_activators | antiInfective | antihelminthic | S. stercoralis | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2013 | 25/06/2013 | Screening | 369953 | 3700 | |
1885 | Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication | T. Cruzi replication | antiInfective | antimicrobial | chagas | cellGrowth | phenotypic | TID | 2 | prospective analytics successful | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/07/2009 | 29/09/2009 | Screening | 303218 | 4394 | ||
651654 | HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity | AK | adenylate kinase | Cryptococcus neoformans | antiInfective | antimicrobial | cryptococcosis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/10/2012 | 19/10/2012 | Screening | 357997 | 735 |
2451 | qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia | FBA | Fructose-bisphosphate aldolase | Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia) | antiInfective | antimicrobial | giardiasis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/03/2010 | 28/04/2010 | Confirmatory | 287738 | 2034 |
540267 | Small Molecules that selectively kill Giardia lamblia: qHTS | Giardia lamblia | antiInfective | antimicrobial | giardiasis | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/07/2011 | 18/07/2011 | Screening | 342452 | 530 | ||
1721 | qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) | PYK | Pyruvate kinase | Leishmania mexicana | antiInfective | antimicrobial | leishmaniasis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/05/2009 | 16/03/2010 | Confirmatory | 292732 | 1088 |
1063 | Leishmania major promastigote HTS | Leishmania promastigote | antiInfective | antimicrobial | leishmaniasis | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/02/2008 | 29/02/2008 | Screening | 196141 | 17620 | ||
1259423 | Primary cell-based high-throughput screening assay for identification of small molecule agonists of Aedes aegypti NPYLR7 [Small Molecule Inhibitors of Mosquito Biting Behavior] | NPYLR7 | mosquito (Aedes aegypti) neuropeptide receptor NPYLR7 | Inhibitors of Mosquito Biting Behavior | antiInfective | antimicrobial | malaria | GFP fluorescence | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2018 | 20/08/2018 | Screening | 265113 | 400 |
449703 | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | P. Falciparum erythrocyte 3D7 | antiInfective | antimicrobial | malaria | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/07/2010 | 03/05/2024 | Confirmatory | 5608 | 4205 | ||
2306 | Inhibition of P. falciparum 3D7 | P. falciparum 3d7 | antiInfective | antimicrobial | malaria | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/01/2010 | 13/05/2010 | Screening | 13456 | 13456 | ||
2302 | Inhibition of P. falciparum Dd2 | P. falciparum Dd2 | antiInfective | antimicrobial | malaria | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/01/2010 | 13/05/2010 | Screening | 13456 | 7921 | ||
449704 | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | P. falciparum erythrocyte W2 | antiInfective | antimicrobial | malaria | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/07/2010 | 03/05/2024 | Confirmatory | 5608 | 4612 | ||
2304 | Inhibition of P. falciparum LDH | P. falciparum LDH | antiInfective | antimicrobial | malaria | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/01/2010 | 13/05/2010 | Screening | 13456 | 0 | ||
1906 | QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). | CTSL1 | Cathepsin L proteinase | PFM18AAPinhibitorsCounterscreen | antiInfective | antimicrobial | malaria | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/08/2009 | 16/06/2010 | Screening | 302663 | 1482 | |
504690 | uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay | G6PD-6PGL | glucose-6-phosphate dehydrogenase | Plasmodium berghei | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/04/2011 | 17/05/2011 | Screening | 348923 | 2710 |
1671177 | Calibr Malaria Delayed Death Assay SOP | Plasmodium falciparum | antiInfective | antimicrobial | malaria | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/08/2021 | 30/08/2022 | Confirmatory | 37708 | 433 | ||
1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | Pf-apPOL | apicoplast DNA polymerase | Plasmodium falciparum | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/10/2022 | 06/10/2022 | Screening | 201181 | 519 |
504832 | Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation | Plasmodium falciparum | antiInfective | antimicrobial | malaria | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/06/2011 | 22/06/2011 | Confirmatory | 304969 | 18055 | ||
504834 | Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation | Plasmodium falciparum | antiInfective | antimicrobial | malaria | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/06/2011 | 22/06/2011 | Confirmatory | 323200 | 22332 | ||
720542 | qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen | AMA1-RON | Plasmodium falciparum | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/07/2013 | 27/07/2013 | Confirmatory | 364096 | 735 | |
1347417 | qHTS Primary assay for Inhibitors of Plasmodium falciparum Dd2 growth in vitro | Plasmodium falciparum | antiInfective | antimicrobial | malaria | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/04/2020 | 06/04/2020 | Confirmatory | 123608 | 5316 | ||
504621 | Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | 811999 | Heat shock protein 90, putative | Plasmodium falciparum (isolate 3D7) | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/03/2011 | 30/03/2011 | Screening | 307132 | 972 |
504582 | In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity | 811941 | HSP40, subfamily A | Plasmodium falciparum (isolate 3D7) | antiInfective | antimicrobial | malaria | survival | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/03/2011 | 31/03/2011 | Screening | 336519 | 2306 |
1445 | Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) | M1AAP | Aminopeptidase N | Plasmodium falciparum (isolate 3D7) | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/12/2008 | 08/12/2008 | Confirmatory | 216987 | 913 |
1619 | Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) | LAP | Leucine aminopeptidase | Plasmodium falciparum (isolate 3D7) | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/03/2009 | 27/03/2009 | Confirmatory | 216988 | 827 |
1822 | QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). | M18AAP | Aspartyl aminopeptidase | Plasmodium falciparum (isolate 3D7) | antiInfective | antimicrobial | malaria | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/06/2009 | 15/06/2010 | Screening | 290726 | 3497 |
1159554 | Plasmodium falciparum Dd2 Sybr green parasite growth Measured in Cell-Based and Microorganism Combination System Using Plate Reader | Plasmodium falciparum Dd2 | antiInfective | antimicrobial | malaria | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/09/2015 | 22/09/2015 | Screening | 93079 | 2144 | ||
485364 | qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins | TGR | thioredoxin-disulfide reductase | Schistosoma mansoni (Blood fluke) | antiInfective | antimicrobial | schistosomiasis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/10/2010 | 06/10/2010 | Confirmatory | 356643 | 10735 |
624268 | Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) | 3662741 | methionine--tRNA ligase | met-tRNA synt | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/06/2012 | 23/07/2012 | Screening | 363803 | 1456 |
624173 | qHTS of Trypanosoma Brucei Inhibitors | TB08.30K1.730 | Uncharacterized protein | T. brucei | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | phenotypic | TID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2012 | 30/05/2012 | Confirmatory | 406726 | 491 |
1117264 | Fluorescence-based biochemical high throughput primary assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1) | REL1 | RNA-editing ligase 1, mitochondrial | Trypanosoma brucei brucei | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/08/2014 | 27/08/2014 | Screening | 89157 | 438 |
1430 | HTS assay for inhibitors of Trypanosoma brucei hexokinase 1 | 3663016 | Phosphotransferase | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/11/2008 | 10/11/2008 | Screening | 220222 | 239 |
485367 | qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase | TB03.3K10.320 | ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/10/2010 | 05/11/2010 | Confirmatory | 330677 | 557 |
624255 | Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_SinglePoint_HTS_Activity | Trypanosoma cruzi | antiInfective | antimicrobial | trypanosomiasis | cellDeathGrowth | phenotypic | TID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/06/2012 | 04/06/2012 | Screening | 76537 | 4582 | ||
1478 | qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) | P25779 | Cruzipain | Trypanosoma cruzi | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/01/2009 | 19/02/2010 | Confirmatory | 195013 | 848 |
1476 | qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) | P25779 | Cruzipain | Trypanosoma cruzi | antiInfective | antimicrobial | trypanosomiasis | enzymeAct | targetBased | phenotypeID | 2 | prospective analytics successful | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/01/2009 | 19/02/2010 | Confirmatory | 195013 | 4500 |
488862 | Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity | PrP_Inhibitors | antiInfective | antiPrion | prionDisease | PrP_reporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/10/2010 | 21/10/2010 | Screening | 334634 | 1167 | |||
1251 | Anti-Viral Drugs Against Arbovirus Infections, a Primary Screen | Bluetongue virus (BTV) | antiInfective | antiviral | BTV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/04/2008 | 14/04/2008 | Screening | 195407 | 715 | ||
651958 | Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate | vOTU | viral ovarian tumor domain protease | Crimean-Congo Hemorrhagic Fever (CCHF) virus | antiInfective | antiviral | CCHFV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/12/2012 | 26/12/2012 | Screening | 368927 | 2045 |
588689 | Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition | P29991 | Genome polyprotein [Cleaved into: Capsid protein C | Dengue virus type 2 | antiInfective | antiviral | Dengue | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2011 | 26/10/2011 | Confirmatory | 338623 | 1013 |
651640 | DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity | dengueVirus | antiInfective | antiviral | Dengue | cellViability | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2012 | 12/10/2012 | Screening | 343305 | 5946 | |||
2234 | Counterscreen for inhibitors of EBNA-1: fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of the Epstein-Barr virus-encoded protein, ZTA. | P03206 | Lytic switch protein BZLF1 | Epstein-Barr virus | antiInfective | antiviral | EBV | counterScreen | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/01/2010 | 15/06/2010 | Screening | 314999 | 485 |
1950 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1). | BKRF1 | BKRF1 protein, Epstein-Barr nuclear antigen 1 | Epstein-Barr virus | antiInfective | antiviral | EBV | FP-DNA-binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/09/2009 | 16/06/2010 | Screening | 302663 | 1022 |
504558 | Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity | LMP1 | Latent membrane protein 1 | Epstein-Barr virus | antiInfective | antiviral | EBV | InfectionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/03/2011 | 24/03/2011 | Screening | 345064 | 2373 |
1085 | uHTS for Small Molecule Inhibitiors of Epstein-Barr Virus Inhibitors | Q1HVG2 | Glycoprotein 42 | Epstein-Barr virus | antiInfective | antiviral | EBV | FP_binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/03/2008 | 03/03/2008 | Screening | 218602 | 926 |
1159524 | High Throughput Screening for Foot and Mouth Disease Virus Antivirals | Foot-and-mouth disease virus | antiInfective | antiviral | FMDV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/07/2015 | 15/07/2015 | Confirmatory | 404062 | 5020 | ||
1745856 | Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Firefly Luciferase Signal | P03308 | Genome polyprotein [Cleaved into: Leader protease | Foot-and-mouth disease virus | antiInfective | antiviral | FMDV | cellDeathGrowth | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/06/2022 | 16/06/2022 | Confirmatory | 117258 | 273 |
1745857 | Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Renilla Luciferase Signal | P03308 | Genome polyprotein [Cleaved into: Leader protease | Foot-and-mouth disease virus | antiInfective | antiviral | FMDV | cellDeathGrowth | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/06/2022 | 16/06/2022 | Confirmatory | 117258 | 373 |
1347131 | qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound library | AAA42670 | Genome polyprotein [Cleaved into: Leader protease | Foot-and-mouth disease virus | antiInfective | antiviral | FMDV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/09/2019 | 12/09/2019 | Confirmatory | 404063 | 1959 |
504329 | Discovery of Small Molecule Probes for H1N1 Influenza NS1A | NS1 | Non-structural protein 1 | Influenza A virus | antiInfective | antiviral | H1N1 | alphaScreen | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 22/02/2011 | Confirmatory | 335224 | 1010 |
2326 | qHTS Assay for Inhibitors of Influenza NS1 Protein Function | NS1 | Non-structural protein 1 | Influenza NS1 | antiInfective | antiviral | H1N1 | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/02/2010 | 01/02/2010 | Confirmatory | 269561 | 1073 |
1259415 | qHTS Assay for inhibitors of the human cytomegalovirus (HCMV) | HCMV inhibitors | antiInfective | antiviral | HCMV | InfectionReporter | phenotypic | TID | 0 | under evaluation | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/06/2018 | 20/06/2018 | Screening | 403256 | 18370 | ||
1918969 | Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress | NEC2 | Nuclear egress membrane protein, Nuclear egress protein 2 | Human cytomegalovirus | antiInfective | antiviral | HCMV | FRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/08/2023 | 02/11/2023 | Screening | 183911 | 278 |
651820 | qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) | HCV inhibitors | antiInfective | antiviral | HCV | InfectionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/11/2012 | 28/11/2012 | Confirmatory | 339573 | 11624 | ||
1845 | Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID) | NS3 | Genome polyprotein | Hepacivirus hominis | antiInfective | antiviral | HCV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/07/2009 | 15/06/2010 | Screening | 290725 | 487 |
1800 | Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) | NS3 | Genome polyprotein | Hepacivirus hominis | antiInfective | antiviral | HCV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/06/2009 | 15/06/2010 | Screening | 290726 | 1635 |
1899 | TR-FRET-based primary biochemical high-throughput screening assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization | ABC47431 | Core protein | Hepacivirus hominis | antiInfective | antiviral | HCV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/08/2009 | 15/06/2010 | Screening | 302663 | 998 |
623901 | Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity | miR122_inhibitors | antiInfective | antiviral | HCV | exprressionReporterLuci | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/03/2012 | 28/03/2012 | Screening | 333274 | 472 | |||
504423 | C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity | ORF73 | LANA | Human herpesvirus 8 | antiInfective | antiviral | HHV-8 | FP_binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/03/2011 | 07/03/2011 | Screening | 336515 | 262 |
2629 | Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction | LANA1 | Protein LANA1 | Human herpesvirus 8 | antiInfective | antiviral | HHV-8 | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/03/2010 | 22/03/2010 | Screening | 323564 | 1946 |
493011 | uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay | APOBEC3A | DNA dC->dU-editing enzyme APOBEC-3A | APOBEC3A_inhibitors | antiInfective | antiviral | HIV | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/01/2011 | 05/01/2011 | Screening | 331753 | 1372 | |
602313 | qHTS for Inhibitors of Vif-A3F Interactions: qHTS | APOBEC3F | DNA dC->dU-editing enzyme APOBEC-3F | APOBEC3F_inhibitors | antiInfective | antiviral | HIV | PPI_FLINT | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/03/2012 | 08/03/2012 | Confirmatory | 383848 | 765 | |
602310 | qHTS for Inhibitors of Vif-A3G Interactions: qHTS | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | APOBEC3G_inhibitors | antiInfective | antiviral | HIV | PPI_FLINT | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/03/2012 | 27/11/2012 | Confirmatory | 402348 | 311 | |
493012 | uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | APOBEC3G_inhibitors | antiInfective | antiviral | HIV | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/01/2011 | 05/01/2011 | Screening | 331753 | 931 | |
651610 | HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity | HIV fussion | antiInfective | antiviral | HIV | cellFussionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/10/2012 | 24/10/2012 | Screening | 354822 | 3866 | ||
463187 | 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC | Hck-Nef | Hck-Nef | HIV type 1 | antiInfective | antiviral | HIV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/09/2010 | 01/09/2010 | Screening | 220222 | 1495 |
372 | HIV-1 RNase H Inhibition | GAG-POL | Gag-Pol polyprotein | HIV type 1 | antiInfective | antiviral | HIV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/03/2006 | 22/08/2008 | Screening | 99768 | 769 |
565 | HIV-1 RT-RNase H MLSCN HTS MH077605 | GAG-POL | Gag-Pol polyprotein | HIV type 1 | antiInfective | antiviral | HIV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2006 | 26/09/2007 | Screening | 65218 | 1250 |
1259389 | HIV1_TAR : FRET assay measuring displacement of FAM and TAMRA-labeled Tat peptide from HIV-1 TAR RNA. | TAR | transactivation response element | HIV type 1 | antiInfective | antiviral | HIV | FRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/03/2018 | 09/03/2018 | Screening | 103073 | 615 |
602346 | Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity | VIF | Virion infectivity factor | HIV type 1 | antiInfective | antiviral | HIV | FRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/03/2012 | 09/03/2012 | Screening | 335681 | 1162 |
179 | NCI AIDS Antiviral Assay | HIV type 1 | antiInfective | antiviral | HIV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | Confirmatory | 41976 | 1527 | ||
704 | Primary biochemical high-throughput screening assay for inhibitors of the HIV Rev RRE RNA interaction (disruption of protein-RNA interaction) | REV | Protein Rev | HIV type 1 | antiInfective | antiviral | HIV | FRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/05/2007 | 06/11/2009 | Screening | 96879 | 769 |
624416 | TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 | ENV | Envelope glycoprotein gp160 | HIV type 1 | antiInfective | antiviral | HIV | TRFRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/07/2012 | 26/07/2012 | Screening | 362577 | 1546 |
1986 | uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. | ENV | Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 | HIV type 1 | antiInfective | antiviral | HIV | viralFusion | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/10/2009 | 30/12/2010 | Confirmatory | 292323 | 890 |
1117319 | High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction | VIF | Virion infectivity factor | HIV-VIF | antiInfective | antiviral | HIV | FRET binding | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/02/2015 | 23/03/2015 | Confirmatory | 258750 | 1498 |
651644 | qHTS Assay for Inhibitors of the HIV-1 protein Vpr | VPR | Protein Vpr | HIV-VPR | antiInfective | antiviral | HIV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/10/2012 | 16/10/2012 | Confirmatory | 361879 | 750 |
743269 | TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration | PSIP1 | PC4 and SFRS1-interacting protein | PSIP1 | antiInfective | antiviral | HIV | FRET binding | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/01/2014 | 31/01/2014 | Screening | 369953 | 2353 |
540256 | qHTS for Inhibitors of binding or entry into cells for Lassa Virus | Lassa virus entry | antiInfective | antiviral | Lassa virus | viralEntry | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/07/2011 | 23/07/2011 | Confirmatory | 297156 | 3648 | ||
540276 | qHTS for inhibitors of binding or entry into cells for Marburg Virus | Margburg virus entry | antiInfective | antiviral | Margburg virus | viralEntry | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/07/2011 | 18/11/2011 | Confirmatory | 284160 | 4700 | ||
841 | Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) | RNA-Dependent RNA Polymerase Complex | Measles Virus | antiInfective | antiviral | Measles | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/11/2007 | 06/11/2007 | Screening | 137777 | 2077 | |
588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | P03300 | Genome polyprotein [Cleaved into: P1; Capsid protein VP0 | Poliovirus type 1 | antiInfective | antiviral | Poliovirus type 1 | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/10/2011 | 18/10/2016 | Other | 151525 | 1001 |
2391 | A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) | Respiratory syncytial virus | antiInfective | antiviral | RSV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2010 | 22/02/2010 | Confirmatory | 313719 | 409 | ||
PLP&3CLP proteasesPChem screens plus phenotypic records @ ChEMBL | PLP&3CLP proteases | PLP&3CLP proteases | SARS-CoV | antiInfective | antiviral | SARS-CoV | proteases& cellDeath | phenotypic&targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | completed | completed | ||||||
1706 | QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) | AAZ82016 | 3C-like protease | SARS-CoV | antiInfective | antiviral | SARS-CoV | enzymeAct | targetBased | phenotypeID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 01/05/2009 | 15/06/2010 | Screening | 290726 | 405 |
485353 | qHTS of Yeast-based Assay for SARS-CoV PLP | REP | Replicase polyprotein 1ab | SARS-CoV | antiInfective | antiviral | SARS-CoV | enzymeAct | targetBased | phenotypeID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 05/10/2010 | 12/11/2010 | Confirmatory | 328641 | 609 |
1903 | Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents | P03070 | Large T antigen | Simian virus 40 (SV40) | antiInfective | antiviral | SV40 | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/08/2009 | 04/03/2011 | Confirmatory | 305355 | 1203 |
493162 | A screen for compounds that inhibit processive DNA synthesis of vaccinia virus | OPG071 | DNA polymerase | Vaccinia virus (VACV) | antiInfective | antiviral | VACV | enzymeAct | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/02/2011 | 19/10/2016 | Other | 45651 | 427 |
720579 | qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS | 3707576 | Ankyrin repeat protein B19 | Vaccinia virus (VACV) | antiInfective | antiviral | VACV | InfectionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/08/2013 | 21/08/2013 | Confirmatory | 306737 | 1931 |
720580 | qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS | 3707576 | Ankyrin repeat protein B19 | Vaccinia virus (VACV) | antiInfective | antiviral | VACV | InfectionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/08/2013 | 19/08/2013 | Confirmatory | 326363 | 1520 |
588727 | A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 | Venezuelan equine encephalitis virus | antiInfective | antiviral | VEEV | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/10/2011 | 30/10/2011 | Confirmatory | 347901 | 453 | ||
720596 | TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) | PRNP | Major prion protein | PRNP | antiInfective | prionDisease | prionDisease | expression | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/09/2013 | 03/09/2013 | Screening | 369953 | 1596 |
686954 | uHTS identification of small molecule inhibitors of Artemis endonuclease activity via a fluorescence intensity assay | DCLRE1C | Protein artemis | artemis_inhibitors | cancer | cancer | acuteLymphoblasticLymphoma | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/04/2013 | 25/04/2013 | Screening | 30104 | 235 | |
8 cell line screens at ChEMBL | BrCa cell lines | cancer | cancer | breast cancer | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | underway | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | ||||||||
avg of cell line screens at ChEMBL | BrCaAvg | cancer | cancer | breast cancer | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | completed | completed | ||||||||
720582 | QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 | ADAM10_inhibitors | cancer | cancer | breastCancer | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/08/2013 | 21/08/2013 | Screening | 369953 | 2294 | |
720648 | QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | ADAM17_inhibitors | cancer | cancer | breastCancer | enzymeActFlint | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/10/2013 | 17/10/2013 | Screening | 369953 | 3080 |
624202 | qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression | BRCA1 | Breast cancer type 1 susceptibility protein | BRCA1 activation | cancer | cancer | breastCancer | expressionReporter | phenotypic&targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/05/2012 | 24/05/2012 | Confirmatory | 376029 | 3978 |
89 | NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 11/04/2024 | Confirmatory | 37232 | 2330 | ||
1794793 | NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 71655 | 2694 | ||
97 | NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 12/04/2024 | Confirmatory | 38502 | 2659 | ||
1794788 | NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 71841 | 2560 | ||
83 | NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 11/04/2024 | Confirmatory | 40400 | 4425 | ||
1794796 | NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 75981 | 4212 | ||
95 | NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 14/04/2024 | Confirmatory | 40090 | 2464 | ||
1794789 | NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 74706 | 3330 | ||
85 | NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 11/04/2024 | Confirmatory | 40193 | 3548 | ||
1794794 | NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 75071 | 5500 | ||
93 | NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 12/04/2024 | Confirmatory | 40779 | 2492 | ||
1794790 | NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 74972 | 2944 | ||
91 | NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | completed | 15/08/2004 | 12/04/2024 | Confirmatory | 38148 | 2490 | ||
1794792 | NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line | breastCancer | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 72767 | 3276 | ||
2717 | Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells | breastCancerStemCellsCadherinNull | cancer | cancer | breastCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/03/2010 | 01/03/2011 | Screening | 300621 | 3187 | ||
629 | HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors | ESR1 | Estrogen receptor, Estrogen receptor | ESR1_inhibitors | cancer | cancer | breastCancer | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/03/2007 | 23/04/2007 | Screening | 86095 | 1442 | |
633 | HTS for Estrogen Receptor-beta Coactivator Binding inhibitors | ESR2 | Estrogen receptor beta | ESR2_inhibitors | cancer | cancer | breastCancer | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/03/2007 | 04/06/2007 | Screening | 86095 | 1114 | |
485317 | HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS | GFER | FAD-linked sulfhydryl oxidase ALR | ALR inhibitors | cancer | cancer | cancer | enzymeAct | targetBased | assayID | 3 | virtual screening, assayID, pathway analysis and repurposing completed | completed | completed | completed | completed | notApplicable | completed | started | notStarted | 29/09/2010 | 18/10/2010 | Screening | 288728 | 10857 |
595 | qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction | Disrupters of an Hsp90 Co-Chaperone Interaction | cancer | cancer | cancerGeneral | PPI_alphascreen | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/02/2007 | 19/10/2007 | Confirmatory | 69668 | 300 | |||
1259310 | AlphaScreen-based biochemical high throughput primary assay to identify activators of the E3 ligase (FBW7). | FBW7 | E3 ligase | E3 ligase activators | cancer | cancer | cancerGeneral | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/04/2017 | 17/04/2017 | Screening | 641445 | 853 | |
651550 | HTS Assay for Inhibitors of Akt Phophorylation: Primary Screen | AKT1 | RAC-alpha serine/threonine-protein kinase | AKT1_inhibitors | cancer | cancer | cancerGeneral | enzymeActPhosphorylation | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/08/2012 | 24/08/2012 | Screening | 356517 | 1139 |
1671190 | Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 | ALOX12 | Polyunsaturated fatty acid lipoxygenase ALOX12 | ALOX12_inhibitors | cancer | cancer | cancerGeneral | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/08/2021 | 18/08/2021 | Confirmatory | 564288 | 6030 | |
881 | qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) | ALOX15B | Polyunsaturated fatty acid lipoxygenase ALOX15B | ALOX15B_inhibitors | cancer | cancer | cancerGeneral | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/12/2007 | 04/03/2011 | Confirmatory | 107252 | 595 | |
489031 | uHTS Fluorescent assay for identification of activators of Apaf-1 | APAF1 | Apoptotic protease-activating factor 1 | APAF1_activators | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/11/2010 | 14/04/2011 | Screening | 331671 | 1041 | |
2517 | qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) | APEX1 | DNA repair nuclease/redox regulator APEX1 | APEX1_inhibitors | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/03/2010 | 16/07/2013 | Confirmatory | 345898 | 1172 | |
2521 | uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay | APLNR | Apelin receptor | APLNR_antagonists | cancer | cancer | cancerGeneral | betaArrestin | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/03/2010 | 13/01/2011 | Screening | 330392 | 1062 | |
504490 | Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction That Mediate GPCR Degradation and Recycling | ARRB1 | Beta-arrestin-1 , cDNA FLJ53544 | ARRB1_inhibitors | cancer | cancer | cancerGeneral | PPI_FLINT | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2011 | 26/03/2011 | Screening | 338373 | 1061 | |
504466 | qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 | ATAD5 | ATPase family AAA domain-containing protein 5 | ATAD5_inhibitors | cancer | cancer | cancerGeneral | reporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2011 | 16/03/2011 | Confirmatory | 330109 | 4174 | |
504467 | qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 | ATAD5 | ATPase family AAA domain-containing protein 5 | ATAD5_inhibitors | cancer | cancer | cancerGeneral | reporterLuci | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | underway | 16/03/2011 | 16/03/2011 | Confirmatory | 330107 | 7652 |
436 | HTS for BAP1 Enzyme inhibitors | BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 | BAP1_inhibitors | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/06/2006 | 03/01/2008 | Screening | 71016 | 346 | |
2528 | qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) | BLM | RecQ-like DNA helicase BLM | BLM_inhibitors | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/03/2010 | 15/03/2010 | Confirmatory | 347933 | 673 | |
1224903 | Identification of CBX7 inhibitors - Primary Alpha Screen | CBX7 | Chromobox protein homolog 7 inhibitors | Chromobox protein homolog 7 inhibitors | cancer | cancer | cancerGeneral | PPI_alphascreen | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/10/2016 | 24/10/2016 | Screening | 64999 | 724 | |
1347074 | Dicer-mediated maturation of pre-microRNA | DICER1 | Dicer | Dicer_inhibitors | cancer | cancer | cancerGeneral | enzimeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/07/2019 | 29/07/2019 | Other | 46715 | 2829 | |
504332 | qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a | EHMT2 | E92 histone-lys N-methyltransferase 2 | EHMT2_inhibitors | cancer | cancer | cancerGeneral | alphaScreenMethylation | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 22/02/2011 | Confirmatory | 348338 | 30875 |
651548 | EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity | EZH2 | Histone-lysine N-methyltransferase EZH2 | EZH2_inhibitors | cancer | cancer | cancerGeneral | enzymeActTRF | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/08/2012 | 23/08/2012 | Screening | 57013 | 201 | |
602261 | uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay | FASN | Fatty acid synthase | FASN_inhibitors | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/02/2012 | 16/02/2012 | Screening | 362063 | 2427 | |
645 | Isolation of Inhibitors of Her-Kinase Expression - 66K library screen | Her-Kinase Expression | cancer | cancer | cancerGeneral | proteinExpressionAlphascreen | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/04/2007 | 16/11/2007 | Screening | 64629 | 448 | |||
624352 | uHTS identification of HIF-2a Inhibitors in a luminesence assay | EPAS1 | Endothelial PAS domain-containing protein 1 | HIF-2a_inhibitors | cancer | cancer | cancerGeneral | expressionReporterLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/07/2012 | 03/07/2012 | Screening | 363840 | 2624 | |
429 | HTS for Tumor Hsp90 Inhibitors | HSP90AA1 | Heat shock protein HSP 90-alpha | HSP90 known inhibitor displacement | cancer | cancer | cancerGeneral | binding | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/06/2006 | 18/10/2007 | Screening | 63696 | 220 |
1259370 | Inhibitors of CDC25B-CDK2/CyclinA interaction | CCNA2 | Cyclin-A2 | Inhibitors of CDC25B-CDK2/CyclinA interaction | cancer | cancer | cancerGeneral | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/02/2018 | 23/02/2018 | Other | 93798 | 679 | |
1347041 | qHTS assay for inhibitors of human lactate dehydrogenase | LDHA | lactate dehydrogenase | lactateDehydrogenaseInhibitors | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/04/2019 | 17/04/2019 | Screening | 476056 | 732 | |
1347076 | qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1 | ABCB1 | ATP-binding cassette, sub-family B , ATP-dependent translocase ABCB1 | MDR1-selective compounds | cancer | cancer | cancerGeneral | cellDeathGrowth | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/07/2019 | 31/07/2019 | Confirmatory | 396029 | 13426 | |
1347075 | qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1 | ABCB1 | ATP-binding cassette, sub-family B , ATP-dependent translocase ABCB1 | MDR1-selective compounds | cancer | cancer | cancerGeneral | cellDeathGrowth | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/07/2019 | 31/07/2019 | Confirmatory | 395981 | 5516 | |
2289 | qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 | miRNA_modulators | cancer | cancer | cancerGeneral | miRNA_stainFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/01/2010 | 25/01/2010 | Confirmatory | 333510 | 3282 | |||
2029 | Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. | CIT2 | Citrate synthase, peroxisomal | mTOR_pathwayModulators | cancer | cancer | cancerGeneral | reporterGFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2009 | 05/04/2011 | Screening | 321534 | 210 | |
2023 | Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. | APE1 | Vacuolar aminopeptidase 1 | mTOR_pathwayModulators | cancer | cancer | cancerGeneral | reporterGFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2009 | 05/04/2011 | Screening | 324734 | 1090 | |
588692 | Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | NLG_inhibitors | cancer | cancer | cancerGeneral | NLG_reporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2011 | 28/11/2011 | Screening | 358025 | 830 | |||
504444 | Nrf2 qHTS screen for inhibitors | NFE2L2 | Nuclear factor erythroid 2-related factor 2 | nrf2Inhibitors | cancer | cancer | cancerGeneral | expressionReporter | targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | notStarted | 15/03/2011 | 15/03/2011 | Confirmatory | 360873 | 7438 |
449763 | uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay | PERK-elF2a-CHOP pathway activators | cancer | cancer | cancerGeneral | exprressionReporterLuci | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/07/2010 | 14/01/2011 | Screening | 331671 | 1124 | |||
588405 | HTS Assay for Peg3 Promoter Inhibitors | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | PPP1R15A | cancer | cancer | cancerGeneral | expressionReporter | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/09/2011 | 23/09/2011 | Screening | 359244 | 6145 |
1347419 | Antagonist identification of Pyk2 oligomerization: high-throughput screening cellular assay | PTK2B | Protein tyrosine kinase 2 beta | Pyk2 | cancer | cancer | cancerGeneral | oligomerizationLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/04/2020 | 22/04/2020 | Other | 98749 | 818 | |
868 | Screen for Chemicals that Inhibit the RAM Network | RAM network inhibitors | cancer | cancer | cancerGeneral | yeastGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/12/2007 | 03/06/2008 | Screening | 194550 | 3545 | |||
1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | RMI FANCM intereaction | cancer | cancer | cancerGeneral | PPI_FP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/02/2016 | 18/04/2016 | Other | 69794 | 402 | |||
624156 | Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity | rosLevels | cancer | cancer | cancerGeneral | rosLevelsFlint | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/05/2012 | 16/05/2012 | Screening | 45939 | 901 | |||
1347056 | Inhibitor identification of TROY dependent signaling using uHTS single point assay | TROY_signalling_inhibitors | cancer | cancer | cancerGeneral | nfkbReporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/06/2019 | 04/06/2019 | Screening | 360657 | 3551 | |||
1259251 | AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of Unc-51 Like Autophagy Activating Kinase 1 (ULK1). | ULK1 | Unc-51 Like Autophagy Activating Kinase 1 | ULK1 | cancer | cancer | cancerGeneral | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/03/2017 | 06/03/2017 | Screening | 30185 | 575 | |
1992 | HTS Colorimetric assay for the identification of compounds that inhibit VHR1 | DUSP3 | Dual specificity protein phosphatase 3 | VHR1_inhibitors | cancer | cancer | cancerGeneral | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/10/2009 | 30/12/2010 | Screening | 49813 | 347 | |
1654 | uHTS absorbance assay for the identification of compounds that inhibit VHR1. | DUSP3 | Dual specificity protein phosphatase 3 | VHR1_inhibitors | cancer | cancer | cancerGeneral | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/04/2009 | 30/12/2010 | Confirmatory | 291006 | 1524 | |
2012 | uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) | EIF4H | Eukaryotic translation initiation factor 4H | EIF4H | cancer | cancer | cancerGeneral | bindingFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/10/2009 | 12/01/2011 | Confirmatory | 290915 | 2744 | |
588458 | uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay | DNMT1 | DNA methyltransferase-1 | DNMT1 | cancer | cancer | cancerGeneral | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/10/2011 | 06/10/2011 | Screening | 359244 | 2975 | |
1789 | Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) | HSP90AA1 | Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens , Heat shock protein HSP 90-alpha, Heat shock protein HSP 90-alpha | HSP90AA1 | cancer | cancer | cancerGeneral | enzymeAct | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/05/2009 | 15/06/2010 | Screening | 290726 | 2649 |
504706 | qHTS assay for re-activators of p53 using a Luc reporter | TP53 | Cellular tumor antigen p53, Cellular tumor antigen p53 | TP53 | cancer | cancer | cancerGeneral | expressionReporter | phenotypic&targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | 27/04/2011 | 27/04/2011 | Confirmatory | 321427 | 201 |
1259400 | qHTS Assay for Antagonists of the Relaxin Receptor RXFP1 | RXFP1 | Relaxin receptor 1 | relaxinInhibitors | cancer | cancer | cancerGeneral | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/03/2018 | 20/03/2018 | Screening | 350177 | 2058 |
167 | NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 80504 | 9618 | |||
165 | NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 80498 | 8083 | |||
157 | NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 81133 | 8837 | |||
175 | NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 81112 | 10175 | |||
155 | NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 81133 | 9814 | |||
161 | NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | yeastScreenWithAlterationsInDnaRepair | cancer | cancer | cancerWithAlterationsInDnaRepair | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 80498 | 9555 | |||
45 | NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52931 | 2856 | ||
1794759 | NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 75289 | 2115 | ||
47 | NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 53205 | 3526 | ||
1794758 | NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 72353 | 3611 | ||
49 | NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 50511 | 3547 | ||
1794752 | NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 74520 | 4513 | ||
53 | NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52778 | 2515 | ||
1794751 | NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 74208 | 1576 | ||
55 | NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 14/04/2024 | Confirmatory | 49685 | 3444 | ||
1794750 | NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 73093 | 3359 | ||
59 | NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line | CNS_tumor | cancer | cancer | CNS_tumor | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 53211 | 3544 | ||
9 cell line screens at ChEMBL | CoCa cell lines | cancer | cancer | colon cancer | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | underway | underway | underway | underway | ||||||||
67 | NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52712 | 3480 | ||
1794742 | NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 72743 | 4943 | ||
77 | NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 48421 | 2752 | ||
1794799 | NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 72852 | 3007 | ||
79 | NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52727 | 4422 | ||
1794798 | NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 75551 | 5013 | ||
71 | NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 53050 | 3475 | ||
1794746 | NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 75530 | 3437 | ||
65 | NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52844 | 3773 | ||
1794748 | NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 15/04/2024 | Screening | 74688 | 5101 | ||
73 | NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 53104 | 3462 | ||
1794800 | NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 75218 | 3369 | ||
81 | NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 53508 | 4024 | ||
1794795 | NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line | colonCancer | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 75327 | 3576 | ||
818 | High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression | colonCancerNotExpressingOncogenicBetaCatenin | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/10/2007 | 16/10/2007 | Screening | 138737 | 2051 | ||
827 | High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor | colonCancerwithPtenDeletion | cancer | cancer | colonCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/10/2007 | 16/10/2007 | Screening | 138417 | 1658 | ||
651661 | Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity | EWS/Fli transcriptional activity inhibitors | cancer | cancer | EwingSarcoma | cellViabilityAlamarBlue | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/10/2012 | 26/10/2012 | Screening | 342236 | 2318 | |||
1794753 | NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line | glioblastoma | cancer | cancer | glioblastoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 73184 | 3470 | ||
1159606 | uHTS identification of small molecule inhibitors of TWEAK-Fn14 interactions, using a cell-based reporter assay | inhibitors of TWEAK-Fn14 interactions | cancer | cancer | glioblastoma | reporterLumiGlo | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/02/2016 | 24/02/2016 | Other | 362063 | 7302 | |||
686971 | qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line | gliomaWithIdh1Mutations | cancer | cancer | glioma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/05/2013 | 09/05/2013 | Confirmatory | 364464 | 7438 | ||
686970 | qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line | HEL-S-26 | Isocitrate dehydrogenase [NADP] | gliomaWithIdh1Mutations | cancer | cancer | glioma | cellDeathGrowth | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/05/2013 | 09/05/2013 | Confirmatory | 364464 | 5966 |
602342 | Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity | miR122_activators | cancer | cancer | hepatocellularCarcinoma | exprressionReporterLuci | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/03/2012 | 16/03/2012 | Screening | 333274 | 1022 | |||
588664 | TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) | ABL1 | Tyrosine-protein kinase ABL1 | ABL1_interaction | cancer | cancer | leukemia | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/10/2011 | 25/10/2011 | Screening | 359207 | 1432 | |
624256 | HTS to identify compounds that promote myeloid differentiation with MLPCN compound set | HOXA9 | Homeobox protein Hox-A9 | HOXA9 | cancer | cancer | leukemia | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/06/2012 | 18/06/2012 | Screening | 358556 | 3721 |
119 | NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 50580 | 5047 | ||
1794778 | NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 70489 | 4627 | ||
1794776 | NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 71675 | 5995 | ||
121 | NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 51855 | 4709 | ||
1794777 | NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 71880 | 4980 | ||
123 | NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52219 | 4310 | ||
1794779 | NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 73777 | 4676 | ||
113 | NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 49781 | 4206 | ||
1794781 | NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 70780 | 4886 | ||
115 | NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 44307 | 5398 | ||
1794780 | NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell line | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 67113 | 5428 | ||
248 | NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 55741 | 1560 | |||
330 | NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice | leukemia | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 15/08/2004 | 44527 | 2353 | |||
1768 | qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide | MEN1 | Menin | Menin-MLL_inhibitors | cancer | cancer | leukemia | PPI | targetBased | assayID | 2 | prospective analytics successful | completed | completed | completed | notStarted | notStarted | notStarted | notStarted | notStarted | 15/05/2009 | 15/05/2009 | Confirmatory | 263421 | 615 |
125 | NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line | renalCancer | cancer | cancer | leukemia | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 48426 | 4751 | ||
11 cell line screens at ChEMBL | LuCa cell lines | cancer | cancer | lung cancer | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | ||||||||
23 | NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 50080 | 3993 | ||
1794757 | NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 73462 | 4776 | ||
25 | NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 52257 | 3432 | ||
1794745 | NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 73968 | 4221 | ||
29 | NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 49416 | 2812 | ||
1794766 | NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 71882 | 3760 | ||
35 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 50295 | 2412 | ||
1794763 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 70939 | 2926 | ||
39 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 52593 | 1983 | ||
1794761 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 15/04/2024 | Screening | 74869 | 2694 | ||
37 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52438 | 3585 | ||
1794755 | NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 73327 | 4240 | ||
33 | NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52717 | 2210 | ||
1794764 | NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 71797 | 2912 | ||
31 | NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 52399 | 3598 | ||
1794756 | NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line | melanoma | cancer | cancer | melanoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 74782 | 3675 | ||
1259374 | AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of microphthalmia-associated transcription factor (MITF) | MITF | cDNA FLJ53142, highly similar to Microphthalmia-associated transcription factor, Melanocyte inducing transcription factor, Microphthalmia-associated transcription factor , Microphthalmia-associated transcription factor isoform | MITF inhibitors | cancer | cancer | melanoma | alphaScreen | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/02/2018 | 20/02/2018 | Screening | 642362 | 5830 |
588334 | MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity | MITF_expressionEnhancers | cancer | cancer | melanoma | expressionReporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/08/2011 | 25/08/2011 | Screening | 300845 | 2272 | |||
493098 | uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay | CCR6 | C-C chemokine receptor type 6 | CCR6_antagonists | cancer | cancer | metastasis | betaArrestinLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/01/2011 | 27/01/2011 | Screening | 340696 | 1654 | |
602244 | uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay | CXCR6 | C-X-C chemokine receptor type 6 | CXCR6_inhibitors | cancer | cancer | metastasis | betaArrestinLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/02/2012 | 13/03/2012 | Screening | 362063 | 1298 | |
652025 | qHTS of IL-2 Activators | IL2 | Interleukin-2 | IL2 | cancer | cancer | neoplasm of thorax | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/02/2013 | 12/02/2013 | Confirmatory | 364617 | 238 | ||
743126 | QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) | PLA2G3 | Group 3 secretory phospholipase A2 | PLA2G3 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/11/2013 | 25/11/2013 | Screening | 369953 | 2089 | ||
651658 | Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity | FGF22 | Fibroblast growth factor 22 | FGF22_inhibitors | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/10/2012 | 19/10/2012 | Screening | 339650 | 5128 | ||
803 | Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2) | GALR2 | Galanin receptor type 2 | GALR2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/09/2007 | 16/06/2010 | Screening | 140088 | 678 | ||
828 | Primary cell-based high-throughput screening assay to identify antagonists of Galanin Receptor 2 (GALR2) | GALR2 | Galanin receptor type 2 | GALR2_antagonists | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/10/2007 | 16/06/2010 | Screening | 140088 | 548 | ||
1346428 | qHTS for Agonists of Human Resolvin D1 Receptor DRV1 | GPR32 | Probable G-protein coupled receptor 32 | GPR32 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/11/2018 | 26/11/2018 | Screening | 47473 | 1217 | ||
2013 | Image-Based HTS for Selective Antagonists for GPR55 | GPR55 | G-protein coupled receptor 55 | GPR55 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/10/2009 | 12/01/2011 | Confirmatory | 291657 | 370 | ||
2718 | Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3 | HDAC3 | Histone deacetylase 3 | HDAC3 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/03/2010 | 29/03/2010 | Screening | 318291 | 483 | ||
759 | HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype | HRAS | GTPase HRas | HRAS | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/07/2007 | 26/10/2009 | Screening | 194628 | 267 | ||
2098 | Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). | HSF1 | Heat shock factor 1 , Heat shock factor protein 1 , Heat shock transcription factor 1 alpha isoform, Heat shock transcription factor 1 beta isoform, Heat shock transcription factor 1 gammaalpha isoform | HSF1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/11/2009 | 04/11/2009 | Screening | 301324 | 2328 | ||
1446 | Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F | JAK2 | Tyrosine-protein kinase , Tyrosine-protein kinase JAK2 | JAK2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/12/2008 | 16/06/2010 | Screening | 217959 | 2390 | ||
504327 | qHTS Assay for Inhibitors of GCN5L2 | KAT2A | Histone acetyltransferase KAT2A | KAT2A | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 22/02/2011 | Confirmatory | 381571 | 792 | ||
2147 | qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) | KDM4E | Lysine-specific demethylase 4E | KDM4E | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/11/2009 | 19/11/2009 | Confirmatory | 226914 | 3523 | ||
504523 | Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity | KEAP1 | Kelch-like ECH-associated protein 1 | KEAP1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2011 | 21/03/2011 | Screening | 336894 | 489 | ||
1700 | Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5) | KLF5 | Epididymis secretory sperm binding protein , Krueppel-like factor 5 | KLF5 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/04/2009 | 29/06/2009 | Screening | 290726 | 671 | ||
873 | Kallikrein 5 1536 HTS | KLK5 | Kallikrein-5 | KLK5 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/12/2007 | 19/11/2008 | Screening | 214187 | 1264 | ||
652039 | Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen | KLK7 | Kallikrein-7 | KLK7 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/02/2013 | 14/02/2013 | Screening | 368927 | 3325 | ||
485360 | qHTS Assay for the Inhibitors of L3MBTL1 | L3MBTL1 | Lethal | L3MBTL1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/10/2010 | 05/10/2010 | Confirmatory | 225309 | 1492 | ||
2174 | Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1). | LYPLA1 | Acyl-protein thioesterase 1 | LYPLA1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/12/2009 | 15/06/2010 | Screening | 314999 | 499 | ||
1529 | Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | MAP3K3 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/03/2009 | 02/03/2009 | Screening | 289573 | 4159 | ||
995 | qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay | MAPK1 | Mitogen-activated protein kinase 1 | MAPK1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/12/2007 | 06/07/2010 | Confirmatory | 70898 | 707 | ||
1454 | qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF | MAPK1 | Mitogen-activated protein kinase 1 | MAPK1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/12/2008 | 19/12/2008 | Confirmatory | 131324 | 544 | ||
746 | Primary biochemical high-throughput screening assay for inhibitors of the c-Jun N-Terminal Kinase 3 (JNK3) | MAPK10 | Mitogen-activated protein kinase 10 | MAPK10 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/06/2007 | 25/06/2007 | Screening | 59788 | 366 | ||
1230 | E3 Ligase HTS_1536 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | MDM2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/03/2008 | 18/03/2009 | Screening | 207811 | 220 | ||
485346 | uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. | MDM4 | Protein Mdm4 | MDM4 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2010 | 04/10/2010 | Screening | 331671 | 10022 | ||
488899 | MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity | MITF | cDNA FLJ53142, highly similar to Microphthalmia-associated transcription factor, Melanocyte inducing transcription factor, Microphthalmia-associated transcription factor , Microphthalmia-associated transcription factor isoform | MITF | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2010 | 25/10/2010 | Screening | 331360 | 2760 | ||
651704 | Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity | MLLT3 | Protein AF-9 | MLLT3 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2012 | 21/02/2013 | Screening | 344459 | 1627 | ||
588354 | Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) | NCOA1 | Nuclear receptor coactivator 1 | NCOA1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/09/2011 | 13/09/2011 | Screening | 359206 | 428 | ||
651957 | Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) | NCOA2 | Nuclear receptor coactivator 2 | NCOA2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/12/2012 | 26/12/2012 | Screening | 368927 | 620 | ||
793 | Primary cell based high-throughput screening assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2) | NPY2R | Neuropeptide Y receptor type 2 | NPY2R | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/08/2007 | 16/06/2010 | Screening | 140088 | 1384 | ||
1359 | Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2 | NPY2R | Neuropeptide Y receptor type 2 | NPY2R | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2008 | 15/06/2010 | Screening | 217959 | 969 | ||
602396 | Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) | NR5A2 | Nuclear receptor subfamily 5 group A member 2 | NR5A2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2012 | 21/09/2012 | Screening | 363803 | 458 | ||
743445 | Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | NSD2 | Histone-lysine N-methyltransferase NSD2 | NSD2 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/04/2014 | 10/04/2014 | Screening | 309684 | 1662 | ||
493036 | Image-Based HTS for Selective Agonists for NTR1 | NTSR1 | Neurotensin receptor type 1 | NTSR1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/01/2011 | 31/03/2011 | Screening | 331753 | 556 | ||
1778 | uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay | OPRK1 | Kappa-type opioid receptor | OPRK1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2009 | 30/12/2010 | Confirmatory | 290355 | 265 | ||
504326 | Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors | OPRM1 | Mu-type opioid receptor | OPRM1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 26/09/2011 | Screening | 335239 | 991 | ||
504357 | Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors | OPRM1 | Mu-type opioid receptor | OPRM1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/02/2011 | 24/02/2011 | Screening | 335239 | 695 | ||
2014 | uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) | PABPC1 | Polyadenylate-binding protein 1 | PABPC1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/10/2009 | 12/01/2011 | Confirmatory | 290915 | 2982 | ||
588489 | uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay | PABPC1 | Polyadenylate-binding protein 1 | PABPC1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/10/2011 | 11/10/2011 | Screening | 359244 | 1307 | ||
588579 | qHTS for Inhibitors of Polymerase Kappa | POLK | DNA polymerase kappa | POLK | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/10/2011 | 20/10/2011 | Confirmatory | 395295 | 2034 | ||
504707 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] | PRKAR1A | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/04/2011 | 27/04/2011 | Screening | 343468 | 285 | ||
764 | HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant | RAC1 | Ras-related C3 botulinum toxin substrate 1 | RAC1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/07/2007 | 25/10/2009 | Screening | 194629 | 219 | ||
757 | HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype | RAC1 | Ras-related C3 botulinum toxin substrate 1 | RAC1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/07/2007 | 26/10/2009 | Screening | 194628 | 521 | ||
602329 | Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity | RAD54L | DNA repair and recombination protein RAD54-like | RAD54L | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/03/2012 | 08/03/2012 | Screening | 358498 | 505 | ||
1347404 | ROC1-CUL1 CTD Inhibitor di-Ub FRET Primary HTS Screen | RBX1 | E3 ubiquitin-protein ligase RBX1 | RBX1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/03/2020 | 13/03/2020 | Screening | 143816 | 859 | ||
2563 | Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme | RCE1 | CAAX prenyl protease 2 | RCE1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2010 | 16/03/2010 | Screening | 294698 | 799 | ||
2549 | qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) | RECQL | ATP-dependent DNA helicase Q1 | RECQL | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2010 | 15/03/2010 | Confirmatory | 234915 | 1245 | ||
1496 | uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb via a fluorescence resonance energy transfer (FRET) assay. | RUNX1 | Runt-related transcription factor 1 | RUNX1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/01/2009 | 29/12/2010 | Screening | 215667 | 993 | ||
1434 | uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. | RUNX1 | Runt-related transcription factor 1 | RUNX1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/11/2008 | 19/01/2011 | Confirmatory | 218234 | 1620 | ||
686992 | Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity | SELE | E-selectin | SELE | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/05/2013 | 21/10/2013 | Screening | 257988 | 963 | ||
2540 | HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) | SENP8 | Sentrin-specific protease 8 | SENP8 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/03/2010 | 13/01/2011 | Screening | 330392 | 4119 | ||
602440 | uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) | SENP8 | Sentrin-specific protease 8 | SENP8 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2012 | 21/03/2012 | Screening | 363840 | 2341 | ||
602393 | Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity | SMARCA4 | Transcription activator BRG1 | SMARCA4 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2012 | 14/03/2012 | Screening | 344733 | 7043 | ||
623870 | ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity | TACC3 | Transforming acidic coiled-coil-containing protein 3 | TACC3 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/03/2012 | 27/03/2012 | Screening | 391179 | 2589 | ||
624354 | uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay | TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B | TNFRSF10B | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/07/2012 | 03/07/2012 | Screening | 363840 | 3764 | ||
588453 | qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS | TXNRD1 | Thioredoxin reductase 1, cytoplasmic | TXNRD1 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/10/2011 | 05/10/2011 | Confirmatory | 386663 | 3977 | ||
651699 | uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay | UBE2M | NEDD8-conjugating enzyme Ubc12 | UBE2M | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2012 | 25/10/2012 | Screening | 363840 | 2123 | ||
1645853 | USP8 deubiquitinase inhibition: Primary qHTS | USP8 | Ubiquitin carboxyl-terminal hydrolase 8 | USP8 | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 2010 | ||
651768 | qHTS for Inhibitors of WRN Helicase | WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | WRN | cancer | cancer | neoplastic disease or syndrome | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/11/2012 | 16/11/2012 | Confirmatory | 364011 | 1678 | ||
19 | NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 53560 | 2992 | ||
1794740 | NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 15/04/2024 | Screening | 74386 | 2485 | ||
21 | NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 50820 | 2137 | ||
1794765 | NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 64389 | 1626 | ||
9 | NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 52001 | 2981 | ||
1794735 | NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 15/04/2024 | Screening | 73643 | 2556 | ||
13 | NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 47537 | 3298 | ||
1794738 | NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 14/04/2024 | Screening | 65189 | 3616 | ||
3 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 49564 | 2467 | ||
1794732 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 15/04/2024 | Screening | 72375 | 2184 | ||
1 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 53214 | 3094 | ||
1794731 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/09/2022 | 15/04/2024 | Screening | 75010 | 2580 | ||
5 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 52046 | 2317 | ||
1794733 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 18/04/2024 | Screening | 73050 | 1747 | ||
7 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 52033 | 4098 | ||
1794736 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 14/04/2024 | Screening | 75211 | 4608 | ||
15 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | underway | underway | underway | notStarted | notStarted | 15/08/2004 | 10/04/2024 | Confirmatory | 48987 | 4260 | ||
1794739 | NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line, single concentration | nonSmallCellLungCarcinoma | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/09/2022 | 12/04/2024 | Screening | 71275 | 5229 | ||
904 | qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature | TP53 | Cellular tumor antigen p53 | nonSmallCellLungCarcinomaWithP53Mutations | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2007 | 06/07/2010 | Confirmatory | 54509 | 528 |
903 | qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature | TP53 | Cellular tumor antigen p53 | nonSmallCellLungCarcinomaWithP53Mutations | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2007 | 06/07/2010 | Confirmatory | 54513 | 338 |
902 | qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature | TP53 | Cellular tumor antigen p53 | nonSmallCellLungCarcinomaWithP53Mutations | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2007 | 06/07/2010 | Confirmatory | 125394 | 1890 |
924 | qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature | TP53 | Cellular tumor antigen p53 | nonSmallCellLungCarcinomaWithP53Mutations | cancer | cancer | nonSmallCellLungCarcinoma | cellDeathGrowth | targetBased | TID-assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2007 | 06/07/2010 | Confirmatory | 124022 | 1156 |
1794786 | NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 72867 | 3166 | ||
101 | NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52609 | 3249 | ||
1794787 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 74864 | 4915 | ||
99 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 51983 | 3749 | ||
1794784 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 73088 | 2443 | ||
105 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 50969 | 2336 | ||
1794783 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 75004 | 1854 | ||
107 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52502 | 2104 | ||
1794782 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 74586 | 2891 | ||
109 | NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 53426 | 3114 | ||
1794785 | NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 73297 | 2087 | ||
103 | NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line | ovarianCancer | cancer | cancer | ovarianCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 51081 | 2532 | ||
1794760 | NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line | prostateCancer | cancer | cancer | prostateCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 16/04/2024 | Screening | 74776 | 2861 | ||
43 | NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line | prostateCancer | cancer | cancer | prostateCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 40598 | 2824 | ||
1794754 | NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line | prostateCancer | cancer | cancer | prostateCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2022 | 14/04/2024 | Screening | 73700 | 2603 | ||
41 | NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line | prostateCancer | cancer | cancer | prostateCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 11/04/2024 | Confirmatory | 40498 | 3034 | ||
686964 | TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide | MBD2 | Methyl-CpG-binding domain protein 2 | MBD2 | cancer | cancer | Reactivate the silenced genes in cancer cells | FRET binding | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/05/2013 | 01/05/2013 | Screening | 369953 | 1149 |
1794775 | NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 15/04/2024 | Screening | 74688 | 3319 | ||
137 | NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52428 | 3081 | ||
1794774 | NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 69851 | 3516 | ||
129 | NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 47090 | 3449 | ||
1794771 | NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 74545 | 3244 | ||
139 | NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52894 | 3233 | ||
1794772 | NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 68322 | 2874 | ||
131 | NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 50188 | 3283 | ||
1794773 | NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 71215 | 4339 | ||
133 | NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 48061 | 3402 | ||
1794767 | NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 74708 | 2495 | ||
145 | NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52967 | 3005 | ||
1794769 | NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 14/04/2024 | Screening | 74445 | 2716 | ||
141 | NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52047 | 1986 | ||
1794768 | NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2022 | 16/04/2024 | Screening | 74677 | 3544 | ||
143 | NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line | renalCancer | cancer | cancer | renalCancer | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/08/2004 | 12/04/2024 | Confirmatory | 52726 | 2935 | ||
598 | Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen | smallCellLungCarcinomaCellLineExpressingTransportDetoxProtMDR1 | cancer | cancer | smallCellLungCarcinoma | cellDeathGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/02/2007 | 16/11/2007 | Screening | 85200 | 5142 | ||
2690 | A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide | superoxideGenerationInhibitors | nonProligerative | biologicalProcess | aging | superoxideFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/03/2010 | 19/05/2010 | Screening | 328830 | 590 | |||
648 | Human Endothelial Cell Proliferation Assay in 384-well format | angiogenesis_modulators | nonProligerative | biologicalProcess | angiogenesis | cellGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/04/2007 | 12/10/2007 | Screening | 86159 | 925 | |||
719 | Human Lung Fibroblast Proliferation Assay | angiogenesis_modulators_secondary | nonProligerative | biologicalProcess | angiogenesis | cellGrowth | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2007 | 27/08/2013 | Screening | 84879 | 937 | ||
1008 | Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1 | BCL2A1 | Bcl-2-related protein A1 | BCL2A1_modulators | nonProligerative | biologicalProcess | apoptosis | PPI_FLINT | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/01/2008 | 27/03/2008 | Screening | 194826 | 237 | |
2129 | Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). | BCL2L1 | Bcl-2-like protein 1 | BCL2L1_modulators | nonProligerative | biologicalProcess | apoptosis | bindingFP_PPI | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/11/2009 | 15/06/2010 | Screening | 314998 | 2199 | |
2462 | Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. | BCL2L11 | Bcl-2-like protein 11 | BCL2L11_inhibitors | nonProligerative | biologicalProcess | apoptosis | enzymeActLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/03/2010 | 03/03/2010 | Screening | 325630 | 216 | |
2732 | HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress | DDIT3 | DNA damage-inducible transcript 3 protein | DDIT3_inhibitors | nonProligerative | biologicalProcess | apoptosis | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/03/2010 | 31/03/2010 | Screening | 218654 | 8241 | |
463141 | Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 | CASP3 | Caspase-3 | procaspase3Activators | nonProligerative | biologicalProcess | apoptosis | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/08/2010 | 07/01/2011 | Screening | 326024 | 350 | |
923 | qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region | caspase1Inhibitors | nonProligerative | biologicalProcess | apoptosisInhibition | enzymeActFlint | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2007 | 12/07/2010 | Confirmatory | 73912 | 779 | |||
504462 | uHTS fluorescent assay for identification of inhibitors of ATG4B | ATG4B | Cysteine protease ATG4B | ATG4B_inhibitors | nonProligerative | biologicalProcess | autophagy | enzymeAct | phenotypic&targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2011 | 16/03/2011 | Screening | 340119 | 1734 |
463193 | High-content cell-based screening for modulators of autophagy | autophagy imaging assay | nonProligerative | biologicalProcess | autophagy | imaging localization | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | 03/09/2010 | 03/09/2010 | Screening | 194528 | 1903 | ||
782 | uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation | EIF4E | Eukaryotic translation initiation factor 4E | EIF4E_inhibition | nonProligerative | biologicalProcess | autophagy | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/07/2007 | 04/03/2011 | Screening | 217332 | 799 | |
2216 | Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex | RanGTP-Importin-beta complex inhibitors | nonProligerative | biologicalProcess | cellDivision | PPI_FRET | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/12/2009 | 23/12/2009 | Screening | 302387 | 3282 | |||
1024 | HTS Assay for Activators of Cytochrome P450 2A9 | CYP2C9 | Cytochrome P450 2C9 | CYP2C9_activators | nonProligerative | biologicalProcess | cytochromesRoles | enzymeActLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/01/2008 | 20/09/2010 | Screening | 95858 | 1368 | |
cell growth assays at ChEMBL | cytotox | nonProligerative | biologicalProcess | cytotoxicity | cellGrowth | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | ||||||||
1665 | High Throughput Imaging Assay for Beta-Catenin | CTNNB1 | Catenin beta-1 | betaCateninTranslocation | nonProligerative | biologicalProcess | dementia | alexaFluorImaging | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/04/2009 | 30/12/2010 | Confirmatory | 193542 | 587 | |
602162 | Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound Set | ABCB6 | ATP-binding cassette sub-family B member 6 | ABCB6_inhibitors | nonProligerative | biologicalProcess | drugTransport | drugTransport | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/12/2011 | 28/12/2011 | Screening | 362098 | 692 | |
504411 | Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB) | DAGLB | Diacylglycerol lipase-beta | DAGLB_inhibitors | nonProligerative | biologicalProcess | endocannabinoidSignaling | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/03/2011 | 03/03/2011 | Screening | 343468 | 202 | |
1865 | Quantitative High-Throughput Screen for Regulators of Epigenetic Control | EpigeneticControl | nonProligerative | biologicalProcess | EpigeneticControl | reporterGFP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2009 | 10/07/2009 | Confirmatory | 272097 | 537 | |||
602363 | Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity | start codon recognition | nonProligerative | biologicalProcess | geneRegulation | yeastGrowthLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/03/2012 | 12/03/2012 | Screening | 347159 | 450 | |||
488896 | HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity | SCARB1 | Scavenger receptor class B member 1 | SCARB1 | nonProligerative | biologicalProcess | Lipid transport | uptake | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2010 | 25/10/2010 | Screening | 319204 | 3065 |
624037 | Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) | CHRM5 | Muscarinic acetylcholine receptor M5 | CHRM5 | nonProligerative | biologicalProcess | M4_AcChBiology | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/04/2012 | 09/05/2012 | Screening | 363803 | 698 | |
624040 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) | CHRM5 | Muscarinic acetylcholine receptor M5 | CHRM5 | nonProligerative | biologicalProcess | M4_AcChBiology | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/04/2012 | 09/05/2012 | Screening | 363803 | 2133 | |
624038 | Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) | CHRM5 | Muscarinic acetylcholine receptor M5 | CHRM5 | nonProligerative | biologicalProcess | M4_AcChBiology | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/04/2012 | 09/05/2012 | Screening | 363803 | 1081 | |
1362 | Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen | mitochondrialFusion | nonProligerative | biologicalProcess | mitochondrialFusion | differentialGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/07/2008 | 17/07/2008 | Screening | 194153 | 4011 | |||
485298 | qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion | mitochondrialFusion | nonProligerative | biologicalProcess | mitochondrialFusion | differentialGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/09/2010 | 29/09/2010 | Confirmatory | 322166 | 738 | |||
1377 | HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. | necrosisByCaspaseInhibitors | nonProligerative | biologicalProcess | necrosis | ATP_lumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/08/2008 | 11/08/2008 | Screening | 217101 | 832 | |||
493091 | uHTS Colorimetric assay for identification of inhibitors of Scp-1 | CTDSP1 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | CTDSP1_inhibitors | nonProligerative | biologicalProcess | nervousSystemDevelopment | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/01/2011 | 26/01/2011 | Screening | 340696 | 2986 | |
651723 | MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity | PGC1aActivators | nonProligerative | biologicalProcess | Oxidative Metabolic Function | acetylationFRET | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/10/2012 | 28/10/2012 | Screening | 345870 | 740 | |||
651687 | MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity | PGC1aInhibitors | nonProligerative | biologicalProcess | Oxidative Metabolic Function | acetylationFRET | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/10/2012 | 23/10/2012 | Screening | 345870 | 601 | |||
624377 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | ASAP1_inhibitors | nonProligerative | biologicalProcess | prospectiveBiology | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2012 | 10/07/2012 | Screening | 362577 | 680 | |
1416 | Primary cell-based high-throughput screening assay to measure PERK inhibition | EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 | PERK_inhibitors | nonProligerative | biologicalProcess | proteinMisfolding | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/10/2008 | 16/06/2010 | Screening | 217959 | 370 | |
1381 | HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. | DyneinTransport | nonProligerative | biologicalProcess | proteinTransport | imagingGFP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/08/2008 | 18/08/2008 | Screening | 219902 | 1036 | |||
761 | HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype | RAS_inhibitors | nonProligerative | biologicalProcess | RAS_pathways | enzymeActFlint | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/07/2007 | 25/10/2009 | Screening | 194628 | 398 | |||
739 | Modulators of Post-Golgi Transport | Modulators of Post-Golgi Transport | nonProligerative | biologicalProcess | secretionPath | yeastCellGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/06/2007 | 04/10/2007 | Screening | 97509 | 875 | |||
738 | Screening for Modulators of Post-Golgi Transport, Control Strain | Modulators of Post-Golgi Transport | nonProligerative | biologicalProcess | secretionPath | yeastCellGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/06/2007 | 04/10/2007 | Screening | 97518 | 4851 | |||
504408 | Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity | HSF1 | Heat Shock Factor-1 | HSF1_activators | nonProligerative | biologicalProcess | stressResponse | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/03/2011 | 07/03/2011 | Screening | 301170 | 5173 | |
2716 | Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 | SUMOylationInhibitors | nonProligerative | biologicalProcess | SUMOylation | yeastGrowthAtpLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/03/2010 | 29/03/2010 | Screening | 318458 | 3322 | |||
1814 | MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators | aSynucleinExpressionActivators | nonProligerative | biologicalProcess | synucleinEffect | expressionReporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/06/2009 | 14/12/2009 | Screening | 303801 | 21690 | |||
588473 | uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex | CRHBP | Corticotropin-releasing factor-binding protein | CRHBP_agonists | nonProligerative | biologicalProcess | toolCompounds | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/10/2011 | 08/10/2011 | Screening | 348923 | 1622 | |
488922 | Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 | KCNK9 | two-pore domain potassium channel | KCNK9_blockers | nonProligerative | biologicalProcess | toolCompounds | TlInflux | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2010 | 01/11/2010 | Screening | 305610 | 3794 | |
804 | Screen for Chemicals that Shorten Yeast Lifespan | lifespan | nonProligerative | biologicalProcess | toolCompounds | yeastGrowth | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/09/2007 | 16/11/2007 | Screening | 138737 | 710 | |||
720700 | Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 , Phosphoinositide phospholipase C | PLCG1 | nonProligerative | biologicalProcess | toolCompoundsMultiDiseases | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 28/01/2014 | Screening | 369953 | 3123 | |
651999 | uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay | COPS5 | COP9 signalosome complex subunit 5 | COPS5 | nonProligerative | biologicalProcess | Ubiquitination | enzymeActFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/01/2013 | 30/01/2013 | Screening | 363840 | 1401 | |
2544 | uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase | ALPI | Intestinal-type alkaline phosphatase | ALPI_inhibitors | nonProligerative | biologicalProcess | alcalinePhosphatase | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/03/2010 | 13/01/2011 | Screening | 330392 | 393 | |
2806 | uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase | ALPI | Alkaline phosphatase | ALPI_inhibitors | nonProligerative | biologicalProcess | alcalinePhosphatase | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2010 | 12/01/2011 | Screening | 331670 | 664 | |
1259354 | Small-molecule inhibitors of ST2 (IL1RL1) | IL1RL1 | Interleukin-1 receptor-like 1 | IL1RL1 | nonProligerative | respiratory | bronchial disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/01/2018 | 02/01/2018 | Screening | 75924 | 1804 | ||
602410 | Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 | KCNK3 | Potassium channel subfamily K member 3 | KCNK3 | nonProligerative | cardioVascular | arterial disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2012 | 16/03/2012 | Screening | 339674 | 2841 | ||
2642 | Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | KCNQ1 | nonProligerative | cardioVascular | congenital heart disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/03/2010 | 18/11/2010 | Screening | 305610 | 3878 | ||
2648 | Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels | KCNQ1 | Potassium voltage-gated channel subfamily KQT member 1 | KCNQ1 | nonProligerative | cardioVascular | congenital heart disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/03/2010 | 18/11/2010 | Screening | 305610 | 1082 | ||
1347048 | Natriuretic polypeptide receptor (hNpr1) antagonism - Primary qHTS | NPR1 | Atrial natriuretic peptide receptor 1 | NPR1 | nonProligerative | cardioVascular | congestive heart failure | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/05/2019 | 27/02/2020 | Other | 76168 | 1231 | ||
1511 | Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents | KCNH2 | Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2 | KCNH2 | nonProligerative | cardioVascular | Rare genetic cardiac disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/01/2009 | 27/03/2010 | Screening | 305610 | 1552 | ||
720551 | qHTS for Inhibitors of KCHN2 3.1: Wildtype qHTS | KCNH2 | Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2 | KCNH2 | nonProligerative | cardioVascular | Rare genetic cardiac disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/07/2013 | 31/07/2013 | Confirmatory | 343666 | 1267 | ||
798 | Factor XIa 1536 HTS | F11 | Coagulation factor XI | F11_modulation | nonProligerative | cardioVascular | antithrombotic | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/09/2007 | 07/10/2008 | Screening | 218707 | 302 | |
800 | Factor XIIa 1536 HTS | F12 | Coagulation factor XII | F12_modulation | nonProligerative | cardioVascular | antithrombotic | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/09/2007 | 04/03/2011 | Screening | 217430 | 649 | |
1046 | Thrombin 1536 HTS | F2 | Prothrombin | F2_modulation | nonProligerative | cardioVascular | antithrombotic | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/02/2008 | 07/10/2008 | Screening | 217233 | 557 | |
2520 | uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay | APLNR | Apelin receptor | APLNR_agonists | nonProligerative | cardioVascular | hypertension | betaArrestin | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/03/2010 | 13/01/2011 | Screening | 330348 | 347 | |
743397 | HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_Activity | CACNA1D | Voltage-dependent N-type calcium channel subunit alpha-1B | CACNA1D_inhibitors | nonProligerative | cardioVascular | hypertension | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/04/2014 | 08/04/2014 | Screening | 335531 | 328 | |
1671463 | High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity | GC-A_PAMs | nonProligerative | cardioVascular | hypertension | cGMP_FRET_competition | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/12/2021 | 08/12/2021 | Screening | 370293 | 519 | |||
707 | Novel sEH inhibitors for the therapeutic treatment of hypertension and inflammation | EPHX2 | Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 | sEH_inhibitors | nonProligerative | cardioVascular | hypertension | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/05/2007 | 02/05/2007 | Screening | 90640 | 310 | |
1910 | Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway | HIF_expressionActivators | nonProligerative | cardioVascular | ischemia | HIF_expressionReporter Lumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/08/2009 | 08/10/2009 | Screening | 300341 | 950 | |||
588492 | uHTS identification of small molecule modulators of myocardial damage | myocardial damage | nonProligerative | cardioVascular | myocardial infarction | cellViability_ATP_lUMI | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2011 | 12/10/2011 | Screening | 359244 | 2272 | |||
1920062 | High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity | GC-B_PAMs | nonProligerative | cardioVascular | myocardialFibrosis | cGMP_FRET_competition | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/02/2024 | 16/02/2024 | Screening | 370293 | 399 | |||
504339 | qHTS Assay for Inhibitors of JMJD2A-Tudor Domain | KDM4A | Lysine-specific demethylase 4A | KDM4A | nonProligerative | biologicalProcess | epigenetics | alphaScreen | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 22/02/2011 | Confirmatory | 384527 | 16920 |
1663 | MLPCN Platelet Activation -Dense Granule Release | plateletActivationInhibitors | nonProligerative | hematologic | thrombosis | ATP_lumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/04/2009 | 09/04/2009 | Screening | 302451 | 661 | |||
1775 | Profiling compound fluorescence on Avidin Beads with 488 nm excitation and 530 nm emission | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | avidinBeadsFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/05/2009 | 24/05/2009 | Other | 217453 | 825 | |||
1776 | Profiling compound fluorescence on GSH Beads with 488 nm excitation and 530 nm emission | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | GshBeadsFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/05/2009 | 28/03/2011 | Other | 194826 | 489 | |||
709 | Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | autofluorescence | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/05/2007 | 25/05/2007 | Screening | 65420 | 3590 | |||
589 | qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | FLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/02/2007 | 01/03/2007 | Other | 58464 | 6214 | |||
590 | qHTS Assay for Spectroscopic Profiling in A350 Spectral Region | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | FLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/02/2007 | 01/03/2007 | Other | 58464 | 6427 | |||
593 | qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region | fluorescentCompounds | nonProligerative | counterscreen | counterscreen | FLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/02/2007 | 27/03/2007 | Other | 58463 | 532 | |||
463104 | uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay | IRE1-XBP1 pathway activators | nonProligerative | cytoprotection | cellRecovery | exprressionReporterLuci | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/08/2010 | 14/01/2011 | Screening | 331671 | 1099 | |||
2052 | HTS for developing T Cell Immune Modulators | ITGAL | Integrin alpha L, Integrin alpha-L , VWFA domain-containing protein | ITGAL | nonProligerative | dermatology | skin disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/10/2009 | 02/03/2010 | Screening | 326271 | 221 | ||
463082 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) | PLA2G7 | Platelet-activating factor acetylhydrolase | PLA2G7 | nonProligerative | dermatology | skin disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/08/2010 | 03/08/2010 | Screening | 326024 | 4934 | ||
2205 | HCS assay for microtubule stabilizers | TUBB | Tubulin beta chain | TUBB | nonProligerative | dermatology | skin disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/12/2009 | 15/12/2009 | Screening | 195821 | 1625 | ||
639 | HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators | ESR1 | Estrogen receptor, Estrogen receptor | ESR1_modulators | nonProligerative | reproductiveSystem | menopauseSymptoms | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/03/2007 | 23/04/2007 | Screening | 86095 | 1151 | |
2557 | HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library | ITGA4 | Integrin alpha-4 | ITGA4 | nonProligerative | gastroIntestinal | intestinal disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2010 | 23/07/2010 | Screening | 326888 | 645 | ||
1645858 | OTUD3 deubiquitinase inhibition: Primary qHTS | OTUD3 | OTU domain-containing protein 3 | OTUD3 | nonProligerative | gastroIntestinal | intestinal disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 334 | ||
2546 | VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity | RORC | Nuclear receptor ROR-gamma | RORC | nonProligerative | gastroIntestinal | intestinal disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/03/2010 | 13/03/2010 | Confirmatory | 304060 | 10600 | ||
624170 | qHTS for Inhibitors of Glutaminase (GLS) | GLS | glutaminase , Glutaminase kidney isoform, mitochondrial | GLS | nonProligerative | geneticDisorder | autosomal recessive disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2012 | 22/05/2012 | Confirmatory | 405291 | 844 | ||
504700 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complex | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | PRKACB | nonProligerative | geneticDisorder | cardioacrofacial dysplasia 2 | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/04/2011 | 22/04/2011 | Screening | 343468 | 273 | ||
1508649 | Cell-based coincidence reporter assay to measure PMP22 gene transcription in S16 Pmp22-F2sN cells - Primary screen | PMP22 | Peripheral myelin protein 22 | PMP22 | nonProligerative | geneticDisorder | chromosomal disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/03/2021 | 31/01/2022 | Confirmatory | 42576 | 834 | ||
886 | qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) | HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 | HSD17B10 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/12/2007 | 12/07/2010 | Confirmatory | 72072 | 2464 | ||
893 | qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 | HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 | HSD17B10 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/12/2007 | 06/07/2010 | Confirmatory | 73912 | 5649 | ||
624414 | qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) | MCOLN1 | Mucolipin-1 | MCOLN1 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/07/2012 | 26/07/2012 | Screening | 400814 | 482 | ||
493208 | Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon | MTOR | Serine/threonine-protein kinase mTOR | MTOR | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/02/2011 | 14/02/2011 | Confirmatory | 43989 | 342 | ||
522 | Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) | NR5A1 | Steroidogenic factor 1 | NR5A1 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/11/2006 | 03/04/2007 | Screening | 64908 | 1225 | ||
525 | Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) | NR5A1 | Steroidogenic factor 1 | NR5A1 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/11/2006 | 03/04/2007 | Screening | 64908 | 359 | ||
651724 | qHTS Assay for Inhibitors of the CtBP/E1A Interaction | RBBP8 | DNA endonuclease RBBP8 | RBBP8 | nonProligerative | geneticDisorder | developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2012 | 29/10/2012 | Screening | 335214 | 1652 | ||
1224905 | High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunits | GNAI3 | Guanine nucleotide-binding protein G | GNAI3 | nonProligerative | geneticDisorder | ear malformation | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/11/2016 | 18/12/2017 | Screening | 204125 | 876 | ||
1947 | Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the serine hydrolase family member Fam108B. | ABHD17B | Alpha/beta hydrolase domain-containing protein 17B | ABHD17B | nonProligerative | geneticDisorder | genetic, familial or congenital disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/09/2009 | 15/06/2010 | Screening | 302663 | 993 | ||
799 | Identification of Molecular Probes that Activate MRP-1 | ABCC1 | Multidrug resistance-associated protein 1 | ABCC1_activators | nonProligerative | geneticDisorder | Pseudoxanthoma elasticum | cellDeathGrowth | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/09/2007 | 20/11/2007 | Screening | 138717 | 842 | |
652017 | Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) | SMARCA2 | cDNA FLJ36757 fis, clone UTERU2018522, highly similar to Human transcriptional activator hSNF2a, cDNA FLJ53181, highly similar to Probable global transcription activator SNF2L2, Probable global transcription activator SNF2L2 , SMARCA2 protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | SMARCA2 | nonProligerative | geneticDisorder | Rare genetic developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/02/2013 | 06/02/2013 | Screening | 368927 | 3838 | ||
1259422 | Luminescence cell-based high throughput primary assay to identify inhibitors of TEAD-YAP interaction. | YAP1 | Transcriptional coactivator YAP1 | YAP1 | nonProligerative | geneticDisorder | Rare genetic developmental defect during embryogenesis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/07/2018 | 31/07/2018 | Screening | 639428 | 9218 | ||
588591 | qHTS for Inhibitors of Polymerase Eta | POLH | DNA polymerase eta | POLH | nonProligerative | geneticDisorder | Rare genetic skin disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/10/2011 | 20/10/2011 | Confirmatory | 388717 | 4730 | ||
720704 | Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | PLCB3 | nonProligerative | geneticDisorder | spondylometaphyseal dysplasia with corneal dystrophy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 14/11/2013 | Screening | 369953 | 662 | ||
720509 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] | FGB | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | FGB_inhibitors | nonProligerative | hematologic | coagulation protein disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2013 | 10/07/2013 | Screening | 369953 | 760 | ||
720508 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] | FGB | Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] | FGB_inhibitors | nonProligerative | hematologic | coagulation protein disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2013 | 10/07/2013 | Screening | 369953 | 498 | ||
540303 | qHTS for Inhibitors of Cell Surface uPA Generation | PLAU | Urokinase-type plasminogen activator | PLAU | nonProligerative | hematologic | inherited bleeding disorder, platelet-type | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/07/2011 | 27/07/2011 | Confirmatory | 325247 | 1021 | ||
624330 | Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens | RACGAP1 | Rac GTPase-activating protein 1 | RACGAP1 | nonProligerative | hematologic | normocytic anemia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/06/2012 | 03/07/2012 | Confirmatory | 342059 | 2057 | ||
504454 | HTS for Beta-2AR agonists via FAP method | ADRB2 | Beta-2 adrenergic receptor | ADRB2_activators | nonProligerative | immune | asthma | betaArrestin | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2011 | 21/09/2011 | Screening | 339297 | 1446 | |
1053197 | Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE) | SIAE | Sialate O-acetylesterase | SIAE | nonProligerative | immune | autoimmune disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/07/2014 | 28/07/2014 | Screening | 369933 | 2555 | ||
449 | Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism Potentiators | S1PR1 | Sphingosine 1-phosphate receptor 1 | S1PR1 | nonProligerative | immune | autoimmune disorder of the nervous system | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/07/2006 | 01/11/2007 | Screening | 55710 | 315 | ||
1159521 | qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway | RORC | RORCgamma | RORCgammaPathwayInhibitors | nonProligerative | immune | autoimmune disorders | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/06/2015 | 25/06/2015 | Confirmatory | 7671 | 874 |
2551 | qHTS for inhibitors of ROR gamma transcriptional activity | RORC | Nuclear receptor ROR-gamma | RORCgammaPathwayInhibitors | nonProligerative | immune | autoimmune disorders | expressionReporter | targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | completed | notStarted | 15/03/2010 | 15/03/2010 | Confirmatory | 305439 | 16717 |
651800 | Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe | TCR-CD3 interaction | nonProligerative | immune | autoimmuneDisorders | PPI_FP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/11/2012 | 19/11/2012 | Screening | 362574 | 1343 | |||
1259398 | human cGAS chemiluminescence screen | CGAS | Cyclic GMP-AMP synthase | cGAS_inhibitors | nonProligerative | immune | autoimmuneDisorders | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2018 | 04/01/2019 | Screening | 281243 | 218 | |
1259399 | mouse cGAS chemiluminescence screen | CGAS | Cyclic GMP-AMP synthase | cGAS_inhibitors | nonProligerative | immune | autoimmuneDisorders | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2018 | 04/01/2019 | Screening | 160326 | 237 | |
1259397 | mouse cGAS RapidFire screen | CGAS | Cyclic GMP-AMP synthase | cGAS_inhibitors | nonProligerative | immune | autoimmuneDisorders | enzymeActMassSpect | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2018 | 04/01/2019 | Screening | 123258 | 226 | |
652197 | MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_Activity | ERAP1 | Endoplasmic reticulum aminopeptidase 1 | ERAP1_inhibitors | nonProligerative | immune | autoimmuneDisorders | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/03/2013 | 27/03/2013 | Screening | 335777 | 499 | |
1919969 | qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway | Antioxidant Response Element | nonProligerative | immune | COPD | expressionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/01/2024 | 30/01/2024 | Tox21 | 7671 | 943 | ||
624171 | qHTS of Nrf2 Activators | NFE2L2 | NFE2 like bZIP transcription factor 2, Nuclear factor erythroid 2-related factor 2 | Nrf2 activators | nonProligerative | immune | COPD | expressionReporter | phenotypic&targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | notStarted | completed | completed | completed | completed | completed | completed | notStarted | 22/05/2012 | 22/05/2012 | Confirmatory | 403871 | 1243 |
1566 | uHTS luminescence assay for the identification of compounds that inhibit NOD2 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | NOD2 | nonProligerative | immune | Crohn's disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/03/2009 | 30/12/2010 | Confirmatory | 292323 | 1836 | ||
485317 | HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS | GFER | FAD-linked sulfhydryl oxidase ALR | ALR activators | nonProligerative | immune | fibrosis | enzymeAct | targetBased | assayID | 3 | virtual screening, assayID, pathway analysis and repurposing completed | completed | completed | completed | completed | notApplicable | notStarted | notStarted | notStarted | 29/09/2010 | 18/10/2010 | Screening | 288728 | 10857 |
743247 | Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity | fibronectinDeposition | nonProligerative | immune | fibrosis | fibronectinAccumulationFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/01/2014 | 13/01/2014 | Screening | 342865 | 297 | |||
602163 | Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA) | MSRA | Mitochondrial peptide methionine sulfoxide reductase , peptide-methionine | MSRA | nonProligerative | immune | fibrosis | enzymeAct | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/01/2012 | 03/01/2012 | Screening | 362026 | 1074 |
1274 | uHTS of small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) | NCF1 | Neutrophil cytosol factor 1 | p47phoxInhibitors | nonProligerative | immune | fibrosis | bindingFP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/05/2008 | 03/06/2008 | Screening | 217454 | 1142 |
1259400 | qHTS Assay for Antagonists of the Relaxin Receptor RXFP1Taking the negative queue for PMs | RXFP1 | Relaxin receptor 1 | relaxin PMs | nonProligerative | immune | fibrosis | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/03/2018 | 20/03/2018 | Screening | 350177 | 2058 |
630 | HTS of Smad transcription factor inhibitors | SMAD3 | Mothers against decapentaplegic homolog 3 | SMAD3 | nonProligerative | immune | fibrosis | bindingFRET | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/03/2007 | 23/03/2007 | Screening | 88033 | 251 |
2676 | qHTS Assay for Agonists of the Relaxin Receptor RXFP1 | RXFP1 | Relaxin receptor 1 | RXFP1 | nonProligerative | immune | fibrosis | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/03/2010 | 15/03/2018 | Confirmatory | 362198 | 1084 |
588855 | qHTS for Inhibitors of TGF-b | TGFB1 | HSPC193, Mothers against decapentaplegic homolog 3 | TGFB1 | nonProligerative | immune | fibrosis | GFP ligand internalization | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/12/2011 | 06/12/2011 | Confirmatory | 403345 | 4970 |
1497 | HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. | ITGB2 | Integrin beta-2 | ITGB2 | nonProligerative | immune | immune deficiency disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/01/2009 | 29/12/2010 | Screening | 92518 | 501 | ||
1259416 | Toxoplasma gondii inhibition HTS in the presence of IFN-y | IFNG | Interferon gamma | IFNG | nonProligerative | immune | Immune dysregulation disease with immunodeficiency | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/07/2018 | 27/07/2018 | Screening | 67275 | 2509 | ||
1645855 | USP17 deubiquitinase inhibition: Primary qHTS | USP17L5 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 | USP17L5 | nonProligerative | immune | immunodeficiency disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 3075 | ||
796 | IL-1B Induced NFkB Translocation - Primary Screen | NFkB_Translocation_inhibitors | nonProligerative | immune | immunomodulation | imagingTranslocation | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/09/2007 | 26/03/2009 | Screening | 94265 | 409 | |||
2796 | Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) | AHR | Aryl hydrocarbon receptor | AHR_activators | nonProligerative | immune | immunomodulation | reporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/04/2010 | 05/08/2010 | Screening | 324747 | 7988 | |
1347428 | Primary qHTS assay for inhibitors of Activation Induced Cytidine Deaminase (AID): AID signal | AICDA | Single-stranded DNA cytosine deaminase | AICDA_inhibitors | nonProligerative | immune | immunomodulation | enzymeActFret | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/06/2020 | 15/06/2021 | Confirmatory | 90878 | 289 | |
887 | qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) | ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | ALOX15_inhibitors | nonProligerative | immune | immunomodulation | enzymeActAbs | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/12/2007 | 06/07/2010 | Confirmatory | 73174 | 1034 | |
696 | Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase | ALPG | Alkaline phosphatase, germ cell type | ALPG_activators | nonProligerative | immune | immunomodulation | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/04/2007 | 30/08/2010 | Confirmatory | 95729 | 1178 | |
651702 | Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library | CTL granule exocytosis | nonProligerative | immune | immunomodulation | flowCytometry | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2012 | 04/03/2013 | Screening | 363875 | 2400 | ||
1246 | Primary HTS assay for chemical inhibitors of TNF alpha stimulated E-Selectin expression | SELE | E-Selectin | E-selectinExpression | nonProligerative | immune | immunomodulation | immunostaining | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/03/2008 | 09/04/2008 | Screening | 118096 | 843 | |
861 | Primary cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 binding | inhibitors of TLR4-MyD88 binding | nonProligerative | immune | immunomodulation | PPI_enzymeComplementation | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/11/2007 | 21/11/2007 | Screening | 195980 | 357 | |||
819 | Primary HTS assay for chemical potentiators of IL-1B stimulated NFkB nuclear translocation | NFkB nuclear translocation | nonProligerative | immune | immunomodulation | immunostainingImaging | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/10/2007 | 26/03/2009 | Screening | 94231 | 282 | |||
435022 | uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation | NFKB1_activation | nonProligerative | immune | immunomodulation | nfkbReporterLumi | phenotypic | 0 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/06/2010 | 14/01/2011 | Screening | 331670 | 1077 | |||
435003 | uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation | NFKB1_activation | nonProligerative | immune | immunomodulation | nfkbReporterLumi | phenotypic | 0 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/06/2010 | 14/01/2011 | Screening | 330392 | 1733 | |||
932 | Primary cell-based high throughput screening assay to measure STAT1 activation | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | STAT1 activation | nonProligerative | immune | immunomodulation | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2007 | 26/09/2011 | Screening | 195980 | 5134 |
802 | Primary HTS assay for chemical inhibitors of TNF alpha stimulated VCAM1 expression | VCAM1 | VCAM1 | VCAM1_expression | nonProligerative | immune | immunomodulation | immunostaining | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/09/2007 | 19/11/2007 | Screening | 94498 | 457 | |
871 | Primary cell-based high throughput screening assay to measure STAT3 activation | STAT3 | Signal transducer and activator of transcription, Signal transducer and activator of transcription 3 | STAT3 | nonProligerative | immune | immunomodulation | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/12/2007 | 11/09/2008 | Screening | 194666 | 1772 |
862 | Primary cell-based high throughput screening assay to measure STAT3 inhibition | STAT3 | Signal transducer and activator of transcription, Signal transducer and activator of transcription 3 | STAT3 | nonProligerative | immune | immunomodulation | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/11/2007 | 11/09/2008 | Screening | 194666 | 1722 |
743279 | qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen | IL1B | Interleukin-1 beta | IL-1b Inflammasome | nonProligerative | immune | Inflammation CASP COPD | IL-1B production | phenotypic&targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | 11/02/2014 | 13/02/2014 | Screening | 362051 | 17187 |
588358 | HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies | pemphigusAntibodiesInhibitors | nonProligerative | immune | pemphigus | antigenAntibodyBindingFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/09/2011 | 22/09/2011 | Screening | 311344 | 1495 | |||
920 | Primary cell-based high throughput screening assay to measure STAT1 inhibition | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | STAT1 | nonProligerative | immune | Primary immunodeficiency due to a defect in innate immunity | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/12/2007 | 11/09/2008 | Screening | 195980 | 695 | ||
588511 | Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) | ANO1 | Anoctamin-1 | ANO1_inhibitors | nonProligerative | immune | psoriasis | [Cl-]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/10/2011 | 27/03/2013 | Screening | 306502 | 3633 | |
1053188 | Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based System Using Plate Reader - 7124-01_Inhibitor_SinglePoint_HTS_Activity | Inhibitors of CD40 Signaling | nonProligerative | immune | rheumatoidArthritis | nfkbReporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/07/2014 | 09/07/2015 | Screening | 82418 | 778 | |||
619 | Fluorescence polarization assay for PLK1 inhibitors | PLK1 | Serine/threonine-protein kinase PLK1 | PLK1 | nonProligerative | immune | type II hypersensitivity reaction disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/03/2007 | 08/08/2007 | Screening | 97099 | 518 | ||
720504 | qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen | PLK1 | Serine/threonine-protein kinase PLK1 | PLK1 | nonProligerative | immune | type II hypersensitivity reaction disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/07/2013 | 09/07/2013 | Confirmatory | 364065 | 10181 | ||
485 | Primary HTS Assay for S1P3 Antagonists | S1PR3 | Sphingosine 1-phosphate receptor 3 | S1PR3 | nonProligerative | immune | type II hypersensitivity reaction disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/10/2006 | 11/06/2010 | Screening | 169141 | 462 | ||
1159537 | qHTS screening for TAG (triacylglycerol) accumulators in algae | fuelBiosynthesis | nonProligerative | industrial | lipidBiosynthesis | TG_levels_FLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/08/2015 | 24/07/2017 | Screening | 43680 | 367 | |||
602429 | uHTS identification of SUMO1-mediated protein-protein interactions | SUMO1 | Small ubiquitin-related modifier 1 | SUMO1 | cancer | cancer | resistanecToRadiation | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/03/2012 | 20/03/2012 | Screening | 363840 | 1202 | ||
540275 | HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 | TRPV1 | Transient receptor potential cation channel subfamily V member 1 | TRPV1 | nonProligerative | metabolicEndocrine | Abnormality of metabolism/homeostasis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/07/2011 | 20/07/2011 | Screening | 316642 | 617 | ||
1508602 | Cell-based high throughput primary assay to identify activators of GPR151 | GPR151 | G-protein coupled receptor 151 | GPR151 | nonProligerative | metabolicEndocrine | body fat percentage | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/07/2020 | 31/07/2020 | Screening | 642701 | 6746 | ||
1016 | Luminescent assay for identification of activators of bovine intestinal alkaline phosphatase | ALPI | Alkaline phosphatase | ALPI_activators | nonProligerative | metabolicEndocrine | cholesterolLevels | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/01/2008 | 27/08/2010 | Screening | 195570 | 326 | |
2524 | uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase | ALPI | Intestinal-type alkaline phosphatase | ALPI_activators | nonProligerative | metabolicEndocrine | cholesterolLevels | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/03/2010 | 13/01/2011 | Screening | 330392 | 537 | |
2805 | uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase | ALPI | Alkaline phosphatase | ALPI_activators | nonProligerative | metabolicEndocrine | cholesterolLevels | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2010 | 12/01/2011 | Screening | 331670 | 785 | |
1224865 | Identify inhibitors of HNF4 alpha protein binding to DNA | NR2A1 | Hepatocyte nuclear factor 4 alpha | HNF4_binding_to_DNA_enhancers | nonProligerative | metabolicEndocrine | congenitalDiabetes | DNA-Prot_binfingFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/09/2016 | 20/09/2016 | Screening | 363839 | 1098 | |
1216 | HTS identification of compounds activating phosphomannose isomerase (PMI) via a fluorescence intensity assay using a near- saturating concentration of mannose 6-phosphat | MPI | Mannose-6-phosphate isomerase | MPI | nonProligerative | metabolicEndocrine | disorder of glycosylation | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/03/2008 | 29/09/2010 | Screening | 194152 | 656 | ||
1220 | HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate | MPI | Mannose-6-phosphate isomerase | MPI | nonProligerative | metabolicEndocrine | disorder of glycosylation | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/03/2008 | 29/09/2010 | Confirmatory | 194152 | 1288 | ||
1209 | HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. | MPI | Mannose-6-phosphate isomerase | MPI | nonProligerative | metabolicEndocrine | disorder of glycosylation | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/03/2008 | 20/09/2010 | Confirmatory | 194152 | 814 | ||
624417 | qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) | GLP1R | Glucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptor | GLP1R | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | assayID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | 26/07/2012 | 26/07/2012 | Confirmatory | 405130 | 6428 | |
493087 | Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) | IDE | Insulin-degrading enzyme | IDE | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/01/2011 | 25/01/2011 | Screening | 335239 | 245 | ||
434962 | Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) | IDE | Insulin-degrading enzyme | IDE | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/06/2010 | 07/06/2010 | Screening | 324747 | 1316 | ||
1296 | Primary screen for compounds that activate Insulin promoter activity in TRM-6 cells | INS | Insulin, Insulin [Cleaved into: Insulin B chain; Insulin A chain] | INS | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2008 | 22/05/2008 | Screening | 128695 | 1039 | ||
1273 | Primary screen for compounds that inhibit Insulin promoter activity in TRM-6 cells | INS | Insulin, Insulin [Cleaved into: Insulin B chain; Insulin A chain] | INS | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/05/2008 | 12/05/2008 | Screening | 127961 | 1153 | ||
1051 | Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/02/2008 | 27/02/2008 | Other | 99314 | 335 | ||
1049 | Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/02/2008 | 21/02/2008 | Other | 196176 | 782 | ||
1048 | Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/02/2008 | 21/02/2008 | Other | 99314 | 390 | ||
631 | Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/03/2007 | 25/01/2008 | Screening | 196177 | 811 | ||
1032 | Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/02/2008 | 15/06/2010 | Screening | 196176 | 670 | ||
731 | Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) | PPARG | Peroxisome proliferator-activated receptor gamma | PPARG | nonProligerative | metabolicEndocrine | endocrine pancreas disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/06/2007 | 16/06/2010 | Screening | 196177 | 519 | ||
485270 | FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) | HCRTR1 | Orexin/Hypocretin receptor type 1 | HCRTR1 | nonProligerative | metabolicEndocrine | Energy balance, obesity | IP1/[Ca++]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/09/2010 | 24/09/2010 | Screening | 326024 | 5748 |
540308 | Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R | MC4R | Melanocortin receptor 4 | MC4R | nonProligerative | metabolicEndocrine | Energy balance, obesity | betaArrestin | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/07/2011 | 27/07/2011 | Screening | 356160 | 3470 |
624287 | qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS | GNAS | Guanine nucleotide-binding protein G | GNAS | nonProligerative | metabolicEndocrine | hereditary hypoparathyroidism | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/06/2012 | 12/06/2012 | Confirmatory | 334825 | 423 | ||
2751 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) | PREPL | Prolyl endopeptidase-like | PREPL | nonProligerative | metabolicEndocrine | inborn disorder of amino acid transport | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/04/2010 | 15/06/2010 | Screening | 324747 | 2221 | ||
1159527 | qHTS assay to identify small molecule agonists of the RXR signaling pathway: | RXR | retinoid X receptor | RXRA_pathway_agonists | nonProligerative | metabolicEndocrine | insulin sensitization | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/07/2015 | 31/07/2015 | Confirmatory | 7671 | 173 |
686940 | Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) | NR2F2 | COUP transcription factor 2 | NR2F2 | nonProligerative | metabolicEndocrine | insulin sensitization | expressionReporter | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/04/2013 | 15/04/2013 | Screening | 369953 | 2602 |
1628 | HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells | InsulinPromoterDownRegulation | nonProligerative | metabolicEndocrine | insulinSignaling | imagingGFP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/03/2009 | 30/12/2010 | Confirmatory | 192372 | 925 | |||
1625 | HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells | InsulinPromoterDownRegulation | nonProligerative | metabolicEndocrine | insulinSignaling | imagingGFP | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/03/2009 | 30/12/2010 | Confirmatory | 192980 | 574 | |||
504847 | Inhibitors of the vitamin D receptor (VDR): qHTS | VDR | Vitamin D3 receptor | VDR | nonProligerative | metabolicEndocrine | nutritional deficiency disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/06/2011 | 24/06/2011 | Confirmatory | 394050 | 3624 | ||
540295 | TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R | MC4R | Melanocortin receptor 4 | MC4R | nonProligerative | metabolicEndocrine | obesity | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/07/2011 | 23/07/2011 | Screening | 356160 | 1703 | ||
1656 | High Throughput Imaging Assay for Hepatic Lipid Droplet Formation | LipidDropletFormation | nonProligerative | metabolicEndocrine | obesity | imagingBodipy | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/04/2009 | 30/12/2010 | Screening | 236434 | 954 | |||
720543 | Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). | ABHD4 | Abhydrolase Domain Containing 4, N-Acyl Phospholipase B | ABHD4_inhibitors | nonProligerative | metabolicEndocrine | obesity | FP_binding | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/07/2013 | 24/07/2013 | Screening | 369953 | 2005 | |
1030 | qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) | ALDH1A1 | Aldehyde dehydrogenase 1A1 | ALDH1A1_inhibitors | nonProligerative | metabolicEndocrine | obesity | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/01/2008 | 15/03/2010 | Confirmatory | 216881 | 16026 | |
2685 | qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells | lipidStorageInhibitors | nonProligerative | metabolicEndocrine | obesity | lipidStainFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/03/2010 | 25/03/2010 | Confirmatory | 320858 | 2061 | |||
651560 | uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | ACP1_inhibitors | nonProligerative | metabolicEndocrine | obesity associated insulin resistance and the metabolic syndrome | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/09/2012 | 04/09/2012 | Screening | 363840 | 817 | |
1259318 | uHTS identification of small molecule modulators of Rev-erb Alpha. | Rev-erb Alpha | nonProligerative | metabolicEndocrine | obesity, diabetes and hyperlipidemia | FP_binding | phenotypic | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/05/2017 | 27/05/2017 | Screening | 371540 | 2956 | ||
651582 | uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay | TriglycerideAccumulationInhibitors | nonProligerative | metabolicEndocrine | obesity, diabetes and hyperlipidemia | TG_levels_FLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/09/2012 | 12/09/2012 | Screening | 226721 | 1501 | |||
602281 | Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) | PLIN5 | Perilipin-5 | PLIN5 | nonProligerative | metabolicEndocrine | obesity, diabetes, and cardiovascular disease | E.complementation PPI binding | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/02/2012 | 29/02/2012 | Screening | 363803 | 2851 |
651710 | FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | RAD52 | DNA repair protein RAD52 homolog | RAD52 | nonProligerative | metabolicEndocrine | systolic blood pressure | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2012 | 26/10/2012 | Screening | 352074 | 1608 | ||
435005 | Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. | b cell apoptosis | nonProligerative | metabolicEndocrine | T1Diabetes | cellDeath | phenotypic | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | 18/06/2010 | 18/06/2010 | Screening | 303500 | 2435 | ||
624172 | qHTS of GLP-1 Receptor Agonists | GLP1R | Glucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptor | GLP1R agonists | nonProligerative | metabolicEndocrine | T2Diabetes | cAMP | targetBased | assayID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | 22/05/2012 | 22/05/2012 | Confirmatory | 373462 | 23 |
624417 | qHTS of GLP-1 Receptor Inverse Agonists: (PAM Mode) (Taking the negative queue for PAMs) | GLP1R | Glucagon-like peptide 1 receptor , Glucagon-like peptide-1 receptor | GLP1R PAMs | nonProligerative | metabolicEndocrine | T2Diabetes | cAMP | targetBased | assayID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | completed | 26/07/2012 | 26/07/2012 | Confirmatory | 405130 | 6428 |
743287 | Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activity | Glucose-dependent insulin secretion | nonProligerative | metabolicEndocrine | T2diabetes | secretion-associated reporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/02/2014 | 24/02/2014 | Screening | 371108 | 2287 | ||
652154 | HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity | PAX8 | Paired box protein Pax-8 | PAX8 | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2013 | 21/03/2013 | Screening | 353950 | 4145 | ||
720707 | qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | RAPGEF3 | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 31/10/2013 | Confirmatory | 364614 | 268 | ||
720709 | qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen | RAPGEF3 | Rap guanine nucleotide exchange factor 3 | RAPGEF3 | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 31/10/2013 | Confirmatory | 364614 | 517 | ||
1479 | Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 | THRB | Thyroid hormone receptor beta | THRB | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/01/2009 | 07/01/2009 | Confirmatory | 276265 | 806 | ||
493084 | qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Agonists. | TRHR | Thyrotropin-releasing hormone receptor | TRHR | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/01/2011 | 25/01/2011 | Screening | 361330 | 651 | ||
504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | TSHR | Thyrotropin receptor | TSHR | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/06/2011 | 25/06/2011 | Screening | 329153 | 670 | ||
504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | TSHR | Thyrotropin receptor | TSHR | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/06/2011 | 27/06/2011 | Screening | 329153 | 670 | ||
926 | qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor | TSHR | Thyrotropin receptor | TSHR | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2007 | 06/07/2010 | Confirmatory | 72026 | 352 | ||
938 | qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 | TSHR | Thyrotropin receptor | TSHR | nonProligerative | metabolicEndocrine | thyroid disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/12/2007 | 06/07/2010 | Confirmatory | 72026 | 1794 | ||
2380 | uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line | beta-cell replication | nonProligerative | metabolicEndocrine | type I and type II diabetes | cellGrowth_ATP_lUMI | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/02/2010 | 13/01/2011 | Screening | 330392 | 956 | |||
743266 | qHTS for PTHR1 Agonists: Primary Screen | PTH1R | Parathyroid hormone/parathyroid hormone-related peptide receptor | PTH1R | nonProligerative | muculoEskeletalConnective | bone development disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/01/2014 | 30/07/2019 | Confirmatory | 405685 | 308 | ||
624296 | A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. | GMNN | Geminin | GMNN | nonProligerative | muculoEskeletalConnective | bone disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/06/2012 | 15/06/2012 | Confirmatory | 343234 | 9888 | ||
624297 | A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. | GMNN | Geminin | GMNN | nonProligerative | muculoEskeletalConnective | bone disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/06/2012 | 15/06/2012 | Confirmatory | 342279 | 6233 | ||
488847 | RNA aptamer-based HTS for inhibitors of GRK2 | GRK2 | Beta-adrenergic receptor kinase 1 | GRK2 | nonProligerative | muculoEskeletalConnective | bone disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/10/2010 | 15/03/2011 | Screening | 327939 | 1924 | ||
618 | Luminescent HTS for small molecule inhibitors of MT1-MMP transcription | MMP14 | Matrix metalloproteinase-14 | MMP14 | nonProligerative | muculoEskeletalConnective | bone disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/03/2007 | 27/08/2010 | Confirmatory | 86733 | 537 | ||
651647 | uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay | MMP14 | Matrix metalloproteinase-14 | MMP14 | nonProligerative | muculoEskeletalConnective | bone disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/10/2012 | 18/10/2012 | Screening | 361500 | 222 | ||
492956 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) | PAFAH2 | Platelet-activating factor acetylhydrolase 2, cytoplasmic | PAFAH2 | nonProligerative | muculoEskeletalConnective | bone fracture related measurement | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/12/2010 | 02/12/2010 | Screening | 335239 | 3325 | ||
2825 | uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast | NLRP3 | NACHT, LRR and PYD domains-containing protein 3, NACHT, LRR and PYD domains-containing protein 3 | NLRP3 | nonProligerative | muculoEskeletalConnective | connective tissue disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/05/2010 | 13/01/2011 | Screening | 330392 | 1295 | ||
485272 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) | PADI4 | Protein-arginine deiminase type-4 | PADI4 | nonProligerative | muculoEskeletalConnective | connective tissue disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/09/2010 | 24/09/2010 | Screening | 326022 | 1334 | ||
504734 | Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. | TLR9 | Toll-like receptor 9 | TLR9 | nonProligerative | muculoEskeletalConnective | connective tissue disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/05/2011 | 09/05/2011 | Screening | 343468 | 734 | ||
2242 | qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease | GAA | Lysosomal alpha-glucosidase | GAA | nonProligerative | muculoEskeletalConnective | familial cardiomyopathy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/01/2010 | 12/01/2010 | Confirmatory | 199169 | 715 | ||
2100 | qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen | GAA | Lysosomal alpha-glucosidase | GAA_inhibitors | nonProligerative | muculoEskeletalConnective | familial cardiomyopathy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/11/2009 | 05/11/2009 | Confirmatory | 302297 | 1165 | ||
1672 | Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 | KCNJ2 | Inward rectifier potassium channel 2 | KCNJ2 | nonProligerative | muculoEskeletalConnective | familial periodic paralysis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/04/2009 | 29/03/2010 | Screening | 305610 | 2592 | ||
540364 | Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter | FXN | Frataxin, mitochondrial | FXN | nonProligerative | muculoEskeletalConnective | Friedreich ataxia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/08/2011 | 08/09/2011 | Screening | 356160 | 1985 | ||
493008 | Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) | TNNI3 | Troponin I, cardiac muscle | TNNI3 | nonProligerative | muculoEskeletalConnective | hypertrophic cardiomyopathy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/12/2010 | 29/12/2010 | Screening | 335239 | 801 | ||
493244 | Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) | TNNI3 | Troponin I, cardiac muscle | TNNI3 | nonProligerative | muculoEskeletalConnective | hypertrophic cardiomyopathy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/02/2011 | 17/02/2011 | Screening | 335238 | 390 | ||
894 | qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD | HPGD | nonProligerative | muculoEskeletalConnective | hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 17/12/2007 | 01/03/2010 | Confirmatory | 148480 | 6428 | ||
588413 | uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay | GLI1 | Zinc finger protein GLI1 | GLI1 | nonProligerative | muculoEskeletalConnective | non-syndromic polydactyly | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2011 | 12/03/2012 | Screening | 338328 | 2501 | ||
1012 | uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assay | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | ALPL_inhibitors | nonProligerative | muculoEskeletalConnective | boneDisease | enzymeActLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/01/2008 | 30/08/2010 | Screening | 195560 | 517 | |
1224904 | HTS for inhibitors of DUX4-mediated transcriptional activation | DUX4 | Double homeobox protein 4 , DUX4 | DUX4_inhibitors | nonProligerative | muculoEskeletalConnective | muscularDystrophy | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/11/2016 | 10/10/2017 | Screening | 36365 | 289 | |
602340 | HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity | C2C12_myopathy | nonProligerative | muculoEskeletalConnective | myotoxicity | ATP_lumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/03/2012 | 28/03/2012 | Screening | 329274 | 2586 | |||
588674 | Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | HIVEP3 | Schnurri-3 | Schnurri-3 Inhibitors | nonProligerative | muculoEskeletalConnective | osteoporosis | exprressionReporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2011 | 17/03/2014 | Screening | 356883 | 1841 | |
1285 | Primary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translation | APP | Amyloid-beta A4 protein, Amyloid-beta precursor protein | APP_inhibitors | nonProligerative | nervousSystem | AD | translation | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/05/2008 | 19/05/2008 | Screening | 193714 | 1590 |
651572 | Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) | ARFGAP1 | ADP-ribosylation factor GTPase-activating protein 1 | ARFGAP1_inhibitors | nonProligerative | nervousSystem | AD | enzymeActFlint | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/09/2012 | 18/09/2012 | Screening | 362539 | 954 |
624126 | Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4) | CHRM4 | Muscarinic acetylcholine receptor M4 | CHRM4_PAMs | nonProligerative | nervousSystem | AD | [Ca++]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2012 | 09/05/2012 | Screening | 363803 | 1450 |
602449 | uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay | mPTP | nonProligerative | nervousSystem | ALS, AD, neurodegeneration | absorbance swelling | phenotypic | TID | 2 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2012 | 28/03/2012 | Screening | 363840 | 5033 | ||
1239 | High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | NFKB1 | nonProligerative | nervousSystem | ALS, AD, neurodegeneration | expressionReporter | targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | notStarted | 17/03/2008 | 26/03/2009 | Screening | 193265 | 3100 |
485349 | qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia | ATM | Serine-protein kinase ATM | ATM_modulators | nonProligerative | nervousSystem | ataxiaTelangiectasia | enzymeActAlphalisa | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2010 | 04/10/2010 | Confirmatory | 322361 | 619 | |
2797 | Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R) | AVPR1A | Vasopressin V1a receptor | AVPR1A_agonists | nonProligerative | nervousSystem | behavioralDisorders | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/04/2010 | 15/06/2010 | Screening | 324747 | 813 | |
588475 | uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex | CRHBP | Corticotropin-releasing factor-binding protein | CRHBP_antagonists | nonProligerative | nervousSystem | drugAddiction | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/10/2011 | 03/01/2012 | Screening | 348923 | 2056 | |
652054 | qHTS of D3 Dopamine Receptor Antagonist: qHTS | DRD3 | Dopaminereceptor3 | D3_antagonists | nonProligerative | nervousSystem | drugAddiction | cAMP_reporter | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/02/2013 | 21/02/2013 | Screening | 364051 | 9106 |
1259245 | Modulation of AMPAR-stargazin complexes | CACNG2 | Voltage-dependent calcium channel gamma-2 subunit | AMPAStargazinComplexModulators | nonProligerative | nervousSystem | epilepsy | membranePotential | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2017 | 22/02/2017 | Other | 40473 | 1400 | |
449739 | Inhibitors of Cav3 T-type Calcium Channels: Primary Screen | CACNA1H | Voltage-dependent T-type calcium channel subunit alpha-1H | CACNA1H_inhibitors | nonProligerative | nervousSystem | epilepsy | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/07/2010 | 09/03/2011 | Screening | 104728 | 4230 | |
504441 | Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity | DYRK1A | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | DYRK1A_inhibitors | nonProligerative | nervousSystem | geneticNeurodevelopmentalDisability | enzymeActADP_glow | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/03/2011 | 10/03/2011 | Screening | 310014 | 1321 | |
1203 | Primary cell-based high-throughput screening assay to identify transcriptional activators of heat shock protein 70 (Hsp70) | HSP70 | heatShockProt70 | Heat shock 70kDa protein 1A | nonProligerative | nervousSystem | HD, AD, PD, ALS, neurodegeneration | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/03/2008 | 12/08/2008 | Screening | 196176 | 82 |
651819 | High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity | MARVELD2 | MARVEL domain-containing protein 2 | MARVELD2 | nonProligerative | nervousSystem | hearing disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/11/2012 | 28/11/2012 | Screening | 362274 | 1085 | ||
729 | Primary Cell-Based High-Throughput Screening to Identify Agonists of the Sphingosine 1-phosphate receptor 2 (S1P2) | S1PR2 | Sphingosine 1-phosphate receptor 2 | S1PR2 | nonProligerative | nervousSystem | hearing disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/06/2007 | 27/11/2007 | Screening | 96879 | 447 | ||
736 | Primary Cell-Based High-Throughput Screening to Identify Antagonists of the Sphingosine 1-phosphate receptor 2 (S1P2) | S1PR2 | Sphingosine 1-phosphate receptor 2 | S1PR2 | nonProligerative | nervousSystem | hearing disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/06/2007 | 10/01/2008 | Screening | 96879 | 207 | ||
651821 | Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats | cagRnaRepeats | nonProligerative | nervousSystem | huntington | rnaBindingFLINT | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/11/2012 | 25/04/2013 | Screening | 368927 | 4667 | |||
1671202 | Alphascreen assay for small molecules abrogating mHTT-CaM Interaction | HTT | Huntingtin | HTT | nonProligerative | nervousSystem | Huntington disease and related disorders | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/10/2021 | 21/10/2021 | Screening | 189882 | 6790 | ||
1508623 | Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter Activity | HTT | Huntingtin | HTT | nonProligerative | nervousSystem | Huntington disease and related disorders | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/01/2021 | 03/04/2021 | Confirmatory | 48068 | 449 | ||
1688 | qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) | HTT | Huntingtin | HTT | nonProligerative | nervousSystem | Huntington disease and related disorders | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/04/2009 | 21/04/2009 | Confirmatory | 220571 | 2380 | ||
1471 | qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) | HTT | Huntingtin | HTT | nonProligerative | nervousSystem | Huntington disease and related disorders | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/12/2008 | 20/03/2009 | Confirmatory | 223611 | 305 | ||
651725 | qHTS Assay for Inhibitors of the Six1/Eya2 Interaction | SIX1 | Homeobox protein SIX1 | SIX1 | nonProligerative | nervousSystem | inherited auditory system disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2012 | 29/10/2012 | Screening | 364053 | 2026 | ||
1671188 | Primary qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2) | GPT2 | Alanine aminotransferase 2 | GPT2 | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/08/2021 | 17/08/2021 | Confirmatory | 98912 | 236 | ||
596 | qHTS Assay for Tau Filament Binding | MAPT | Microtubule-associated protein, Microtubule-associated protein tau | MAPT | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/02/2007 | 20/12/2007 | Confirmatory | 69668 | 1391 | ||
1468 | qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization | MAPT | Microtubule-associated protein, Microtubule-associated protein tau | MAPT | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/12/2008 | 30/12/2008 | Confirmatory | 271402 | 1048 | ||
1671194 | Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression | SNCA | Alpha-synuclein | SNCA | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/08/2021 | 01/09/2021 | Confirmatory | 140118 | 236 | ||
652106 | qHTS of alpha-syn Inhibitors | SNCA | Alpha-synuclein | SNCA | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2013 | 14/03/2013 | Confirmatory | 368791 | 501 | ||
1347073 | qHTS of TDP-43 Inhibitors: NCGC Sytravon Library Screen | TARDBP | TAR DNA-binding protein 43 | TARDBP | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/07/2019 | 23/07/2019 | Confirmatory | 45163 | 203 | ||
485290 | qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/09/2010 | 28/09/2010 | Confirmatory | 344442 | 978 | ||
686978 | qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT | TDP1 | cDNA FLJ13452 fis, clone PLACE1003176, highly similar to Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1 | TDP1 | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/05/2013 | 16/05/2013 | Confirmatory | 416824 | 63248 | ||
686979 | qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT | TDP1 | cDNA FLJ13452 fis, clone PLACE1003176, highly similar to Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1 | TDP1 | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/05/2013 | 16/05/2013 | Confirmatory | 416856 | 49238 | ||
720702 | Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) | TDP2 | Tyrosyl-DNA phosphodiesterase 2 | TDP2 | nonProligerative | nervousSystem | inherited neurodegenerative disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 29/10/2013 | Screening | 369953 | 1241 | ||
560 | Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) | RORA | Nuclear receptor ROR-alpha | RORA | nonProligerative | nervousSystem | intellectual developmental disorder with or without epilepsy or cerebellar ataxia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2006 | 11/04/2007 | Screening | 64908 | 979 | ||
561 | Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA) | RORA | Nuclear receptor ROR-alpha | RORA | nonProligerative | nervousSystem | intellectual developmental disorder with or without epilepsy or cerebellar ataxia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/12/2006 | 03/04/2007 | Screening | 64908 | 278 | ||
662 | Cell signaling CRE-BLA (Fsk stim) | CREB | cyclic-AMP Responsive Element Binding Protein | _modulators | nonProligerative | nervousSystem | longTermMemory | reporterLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/04/2007 | 12/04/2007 | Confirmatory | 69669 | 1744 | |
1415 | Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. | GNAO1 | Guanine nucleotide-binding protein G | GNAO1 | nonProligerative | nervousSystem | Mendelian neurodevelopmental disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/10/2008 | 01/12/2008 | Screening | 218528 | 711 | ||
1439 | Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. | GNAO1 | Guanine nucleotide-binding protein G | GNAO1 | nonProligerative | nervousSystem | Mendelian neurodevelopmental disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/12/2008 | 01/12/2008 | Screening | 218528 | 770 | ||
1423 | Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. | GNAO1 | Guanine nucleotide-binding protein G | GNAO1 | nonProligerative | nervousSystem | Mendelian neurodevelopmental disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/11/2008 | 01/12/2008 | Screening | 218528 | 750 | ||
1456 | Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen | SLC12A5 | Solute carrier family 12 member 5 | SLC12A5 | nonProligerative | nervousSystem | monogenic epilepsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/12/2008 | 23/12/2008 | Other | 189132 | 4127 | ||
422 | HTS for 14-3-3 protein interaction modulators | YWHAG | 14-3-3 protein gamma | YWHAG | nonProligerative | nervousSystem | monogenic epilepsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/06/2006 | 12/08/2008 | Screening | 157962 | 312 | ||
489030 | uHTS Fluorescent assay for identification of inhibitors of Apaf-1 | APAF1 | Apoptotic protease-activating factor 1 | APAF1_inhibitors | nonProligerative | nervousSystem | neurodegeneration | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/11/2010 | 14/04/2011 | Screening | 331671 | 2353 | |
1276 | Primary screen for compounds that activate Alzheimer's amyloid precursor | APP | Amyloid-beta A4 protein, Amyloid-beta precursor protein | APP_inhibitors | nonProligerative | nervousSystem | neurodegeneration | reporterLuci | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/05/2008 | 13/05/2008 | Screening | 193400 | 1987 |
1347071 | qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary Screen | APP | Amyloid-beta precursor protein | APP_inhibitors | nonProligerative | nervousSystem | neurodegeneration | yeastsViability | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/07/2019 | 20/07/2019 | Confirmatory | 404343 | 257 | |
1236 | uHTS for Calpain Inhibitors | CAPN2 | Calpain-2 catalytic subunit | calpainInhibitors | nonProligerative | nervousSystem | neurodegeneration | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2008 | 14/03/2008 | Screening | 218602 | 799 | |
686996 | VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 | CASP6 | Caspase-6 | Caspase6Inhibitors | nonProligerative | nervousSystem | neurodegeneration | enzymeActFlint | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/05/2013 | 23/05/2013 | Screening | 344318 | 1854 | |
588814 | Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) | CHRM1 | Muscarinic acetylcholine receptor M1 | CHRM1_agonists | nonProligerative | nervousSystem | neurodegeneration | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/11/2011 | 09/05/2012 | Screening | 359207 | 1189 | |
626 | Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen | CHRM1 | Muscarinic acetylcholine receptor M1 | CHRM1_allosteric_activators | nonProligerative | nervousSystem | neurodegeneration | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2007 | 19/09/2007 | Screening | 63676 | 1938 | |
588819 | Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). | CHRM1 | Muscarinic acetylcholine receptor M1 | CHRM1_PAMs | nonProligerative | nervousSystem | neurodegeneration | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/11/2011 | 09/05/2012 | Screening | 359207 | 316 | |
652048 | qHTS of D3 Dopamine Receptor Agonist: qHTS | DRD3 | Dopaminereceptor3 | D3_agonists | nonProligerative | nervousSystem | neurodegeneration | cAMP_reporter | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/02/2013 | 12/03/2013 | Screening | 407539 | 2380 | |
652051 | qHTS of D3 Dopamine Receptor Potentiators: qHTS | DRD3 | Dopaminereceptor3 | D3_PAMs | nonProligerative | nervousSystem | neurodegeneration | cAMP_reporter | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/02/2013 | 21/02/2013 | Screening | 407539 | 2380 | |
540317 | HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails | CBX1 | Chromobox protein homolog 1 | HP1-betaChromodomainInteractionsInhibitors | nonProligerative | nervousSystem | neurodegeneration | PPI_alphascreen | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/07/2011 | 28/07/2011 | Confirmatory | 383363 | 2142 | |
1117267 | Luminescence-based cell-based primary high throughput screening assay to identify activators of Transthyretin (TTR) transcription | HEL111 | Transthyretin, Transthyretin | HEL111 | nonProligerative | nervousSystem | neurodegeneration | transcription | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/08/2014 | 29/08/2014 | Screening | 91909 | 1155 |
1460 | qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding | MAPT | Microtubule-associated protein, Microtubule-associated protein tau | MAPT | nonProligerative | nervousSystem | neurodegeneration | DFLINT aggregation | phenotypic&targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/12/2008 | 30/12/2008 | Confirmatory | 267412 | 5703 |
488975 | Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) | SLC5A7 | High affinity choline transporter 1 | SLC5A7 | nonProligerative | nervousSystem | neurodegeneration | Ch-transport-coupled Na+ flow: MP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/11/2010 | 17/11/2010 | Screening | 306502 | 2634 |
652104 | qHTS of TDP-43 Inhibitors | TARDBP | TAR DNA-binding protein 43 | TARDBP | nonProligerative | nervousSystem | neurodegeneration | yeastReporter | targetBased | TID | 3 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2013 | 14/03/2013 | Confirmatory | 403703 | 7150 |
1481 | Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition | VCP | Transitional endoplasmic reticulum ATPase | VCP | nonProligerative | nervousSystem | neurodegeneration | enzymeAct | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/01/2009 | 16/06/2010 | Screening | 217959 | 923 |
588795 | qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). | FEN1 | Flap endonuclease 1 | FEN1_inhibitors | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/11/2011 | 16/11/2011 | Confirmatory | 386270 | 1331 | ||
493131 | Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity | FOSB | Protein FosB | FOSB | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/01/2011 | 31/01/2011 | Screening | 337391 | 3330 | ||
1259313 | uHTS identification of small molecule modulators of NR3A | GRIN3A | GRIN3A | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/05/2017 | 13/05/2017 | Screening | 339772 | 8480 | |||
1974 | Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). | GSTO1 | Glutathione S-transferase omega-1 | GSTO1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/10/2009 | 16/06/2010 | Screening | 302663 | 3200 | ||
1645851 | Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (IP6K1) | IP6K1 | Inositol hexakisphosphate kinase 1 | IP6K1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/04/2021 | 20/04/2021 | Confirmatory | 143229 | 1157 | ||
1531 | Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | MAP4K2 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/03/2009 | 02/03/2009 | Screening | 289465 | 3276 | ||
1530 | Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutant | MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 | MAP4K2 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/03/2009 | 02/03/2009 | Screening | 289539 | 1003 | ||
2057 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variant | MCL1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/10/2009 | 15/06/2010 | Screening | 314998 | 2139 | ||
1021 | uHTS of Mcl-1/Bid interaction inhibitors | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variant | MCL1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/01/2008 | 08/01/2008 | Screening | 218602 | 2129 | ||
1022 | uHTS of Mcl-1/Noxa interaction inhibitors | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 , MCL1 apoptosis regulator, BCL2 family member, Myeloid cell leukemia ES variant | MCL1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/01/2008 | 08/01/2008 | Screening | 217330 | 3334 | ||
1448 | Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3) | MCOLN3 | Mucolipin-3 | MCOLN3 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/12/2008 | 16/06/2010 | Screening | 217959 | 632 | ||
602229 | Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) | NR2E3 | Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b , Photoreceptor-specific nuclear receptor | NR2E3 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/01/2012 | 26/01/2012 | Screening | 362026 | 1281 | ||
2300 | TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). | NR2E3 | Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b , Photoreceptor-specific nuclear receptor | NR2E3 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/01/2010 | 15/06/2010 | Screening | 314998 | 380 | ||
492953 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) | PAFAH1B2 | Platelet-activating factor acetylhydrolase IB subunit alpha2 | PAFAH1B2 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/12/2010 | 02/12/2010 | Screening | 335239 | 4158 | ||
1346378 | qHTS for small molecular inhibitors of PI4K2A | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha | PI4K2A | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/11/2018 | 26/11/2018 | Screening | 414643 | 532 | ||
652105 | qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | PIP4K2A | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/03/2013 | 04/06/2024 | Confirmatory | 328860 | 4078 | ||
1631 | qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase | PKM | Pyruvate kinase PKM | PKM | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/03/2009 | 19/06/2009 | Confirmatory | 263662 | 892 | ||
485314 | qHTS Assay for Inhibitors of DNA Polymerase Beta | POLB | DNA polymerase beta | POLB | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/09/2010 | 29/09/2010 | Confirmatory | 334457 | 4509 | ||
2130 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). | PPME1 | Protein phosphatase methylesterase 1 | PPME1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/11/2009 | 15/06/2010 | Screening | 314999 | 1683 | ||
2235 | Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | PPP1CA | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/01/2010 | 15/06/2010 | Screening | 314999 | 2841 | ||
652257 | Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) | PRMT1 | Protein arginine N-methyltransferase 1 | PRMT1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/04/2013 | 02/04/2013 | Screening | 369953 | 4757 | ||
727 | Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) | PTK2 | Focal adhesion kinase 1 | PTK2 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/05/2007 | 11/09/2007 | Screening | 96879 | 811 | ||
588621 | uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay | PTPN5 | Tyrosine-protein phosphatase non-receptor type 5 | PTPN5 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/10/2011 | 24/10/2011 | Screening | 359244 | 887 | ||
652163 | S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity | S100A4 | Protein S100-A4 | S100A4 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/03/2013 | 22/03/2013 | Screening | 352235 | 501 | ||
624204 | uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay | SENP1 | SENP1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/05/2012 | 11/10/2012 | Screening | 363840 | 774 | |||
2599 | uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) | SENP6 | cDNA FLJ11355 fis, clone HEMBA1000141, highly similar to Sentrin-specific protease 6, Sentrin-specific protease 6 , SUMO specific peptidase 6 | SENP6 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/03/2010 | 12/01/2011 | Screening | 330392 | 5817 | ||
588478 | A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | UCHL5 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/10/2011 | 18/10/2016 | Other | 330707 | 1075 | ||
687016 | Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide | UHRF1 | E3 ubiquitin-protein ligase UHRF1 | UHRF1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/05/2013 | 31/05/2013 | Screening | 369953 | 2779 | ||
743255 | Inhibitors of USP1/UAF1: Primary Screen | USP1 | Ubiquitin carboxyl-terminal hydrolase 1 | USP1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 16/01/2014 | 16/01/2014 | Confirmatory | 389569 | 904 | ||
1645857 | USP28 deubiquitinase inhibition: Primary qHTS | USP28 | Ubiquitin carboxyl-terminal hydrolase 28 | USP28 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 1413 | ||
1645860 | USP30 deubiquitinase inhibition: Primary qHTS | USP30 | Ubiquitin carboxyl-terminal hydrolase 30 | USP30 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 2500 | ||
1321 | Primary Cell-based High Throughput Screening Assay for Inhibitors of Wee1 Degradation | WEE1 | Wee1-like protein kinase | WEE1 | nonProligerative | nervousSystem | neurodegeneration | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/06/2008 | 15/06/2010 | Screening | 217959 | 2616 | ||
880 | qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) | GNAI1 | Guanine nucleotide-binding protein G | GNAI1 | nonProligerative | nervousSystem | Neurodevelopmental disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/12/2007 | 05/08/2009 | Confirmatory | 229888 | 1007 | ||
504333 | qHTS Assay for Inhibitors of BAZ2B | BAZ2B | Bromodomain adjacent to zinc finger domain protein 2B | BAZ2B_modulators | nonProligerative | nervousSystem | neurodevelopmentalDisorders | alphaScreen | targetBased | phenotypeID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/02/2011 | 22/02/2011 | Confirmatory | 356826 | 15709 |
2073 | Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay | CACNA1B | Voltage-dependent N-type calcium channel subunit alpha-1D | CACNA1B_modulators | nonProligerative | nervousSystem | pain | PPI_FRET | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/10/2009 | 08/10/2010 | Confirmatory | 292323 | 567 | |
652010 | Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 | NR0B1 | Nuclear receptor subfamily 0 group B member 1 | NR0B1 | nonProligerative | nervousSystem | palsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/02/2013 | 01/02/2013 | Screening | 368927 | 4094 | ||
504766 | Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) | NR0B1 | Nuclear receptor subfamily 0 group B member 1 | NR0B1 | nonProligerative | nervousSystem | palsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 18/05/2011 | 20/06/2011 | Screening | 343468 | 3417 | ||
624125 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) | CHRM4 | Muscarinic acetylcholine receptor M4 | CHRM4_antgonists | nonProligerative | nervousSystem | parkinson | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2012 | 11/09/2013 | Screening | 363803 | 2629 | |
504660 | Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS | DRD1 | Dopaminereceptor1 | D1_activators | nonProligerative | nervousSystem | parkinson | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/04/2011 | 13/04/2011 | Screening | 361330 | 3713 | |
624465 | Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Agonists | DRD2 | Dopaminereceptor2 | D2_agonists | nonProligerative | nervousSystem | parkinson | betaArrestinLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/08/2012 | 07/08/2012 | Other | 359518 | 300 | |
485358 | HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists | DRD2 | Dopaminereceptor2 | D2_agonists | nonProligerative | nervousSystem | parkinson | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/10/2010 | 05/10/2010 | Screening | 335652 | 1779 | |
624464 | Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators | DRD2 | Dopaminereceptor2 | D2_PAMs | nonProligerative | nervousSystem | parkinson | betaArrestinLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/08/2012 | 07/08/2012 | Other | 357537 | 806 | |
485347 | HTS Assay for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Primary Screen for Potentiators | DRD2 | Dopaminereceptor2 | D2_PAMs | nonProligerative | nervousSystem | parkinson | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2010 | 05/10/2010 | Screening | 339887 | 1178 | |
1813 | MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors | aSynucleinExpressionInhibitors | nonProligerative | nervousSystem | PD | expressionReporterLumi | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/06/2009 | 14/12/2009 | Screening | 303801 | 2498 | |||
641 | Allosteric Modulators of D1 Receptors: Primary Screen | DRD1 | Dopamine receptor D1 | D1 | nonProligerative | nervousSystem | PD | cAMP_reporter | targetBased | assayID | 3 | virtual screening, assayID, pathway analysis and repurposing completed | completed | completed | completed | completed | notApplicable | completed | notStarted | notStarted | 02/04/2007 | 16/11/2007 | Screening | 57705 | 3413 |
624466 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) | TAAR1 | Trace amine-associated receptor 1 | TAAR1 | nonProligerative | nervousSystem | PD | [Ca++]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/08/2012 | 16/08/2012 | Screening | 362577 | 5374 |
624127 | Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4) | CHRM4 | Muscarinic acetylcholine receptor M4 | CHRM4_agonists | nonProligerative | nervousSystem | psychosis | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2012 | 09/05/2012 | Screening | 363803 | 502 | |
504652 | Antagonist of Human D 1 Dopamine Receptor: qHTS | DRD1 | Dopaminereceptor1 | D1_inhibitors | nonProligerative | nervousSystem | psychosis | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/04/2011 | 12/04/2011 | Screening | 355805 | 11440 | |
624463 | Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Antagonists | DRD2 | Dopaminereceptor2 | D2_antagonists | nonProligerative | nervousSystem | psychosis | betaArrestinLumi | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/08/2012 | 07/08/2012 | Other | 362274 | 1056 | |
485344 | HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists | DRD2 | Dopaminereceptor2 | D2_antagonists | nonProligerative | nervousSystem | psychosis | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/10/2010 | 04/10/2010 | Screening | 336308 | 6862 | |
2156 | Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels | KCNQ2 | Potassium voltage-gated channel subfamily KQT member 2 | KCNQ2 | nonProligerative | nervousSystem | Rare genetic epilepsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/11/2009 | 30/03/2010 | Screening | 305609 | 3405 | ||
2239 | Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels | KCNQ2 | Potassium voltage-gated channel subfamily KQT member 2 | KCNQ2 | nonProligerative | nervousSystem | Rare genetic epilepsy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/01/2010 | 30/03/2010 | Screening | 305600 | 1644 | ||
1745845 | Primary qHTS for Inhibitors of ATXN expression | ATXN2 | Ataxin-2 | ATXN2_repressors | nonProligerative | nervousSystem | spinocerebellarAtaxia | reporterLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/04/2022 | 01/02/2023 | Confirmatory | 358434 | 2554 | |
1347120 | qHTS for Suppressors of FUS Proteinopathy: Primary screen using FUS-linked yeast assay | FUS | RNA-binding protein FUS | FUS_asupressors | nonProligerative | nervousSystem | sporadic amyotrophic lateral sclerosis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/09/2019 | 07/09/2019 | Confirmatory | 385746 | 932 | ||
778 | CYP2C19 Assay | CYP2C19 | Cytochrome P450 2C19 | CYP2C19_inhibitors | nonProligerative | notSpecified | notSpecified | enzymeActLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/07/2007 | 27/08/2010 | Screening | 95857 | 20295 | |
777 | CYP2C9 Assay | CYP2C9 | Cytochrome P450 2C9 | CYP2C9_inhibitors | nonProligerative | notSpecified | notSpecified | enzymeActLuci | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/07/2007 | 27/08/2010 | Screening | 95858 | 18730 | |
2099 | Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity | KDM4C | KDM4C | nonProligerative | otherPhenotypes | age at menarche | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/11/2009 | 05/11/2009 | Screening | 326066 | 228 | |||
1861 | Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7). | NPBWR1 | Neuropeptide B/W receptor 1, Neuropeptides B/W receptor type 1 | NPBWR1 | nonProligerative | otherPhenotypes | age at menarche | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/07/2009 | 20/07/2009 | Screening | 290726 | 3127 | ||
1441 | Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. | RGS16 | Regulator of G-protein signaling 16 | RGS16 | nonProligerative | otherPhenotypes | circadian rhythm | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/12/2008 | 01/12/2008 | Screening | 218528 | 826 | ||
1461 | qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction | NPSR1 | Neuropeptide S receptor | NPSR1 | nonProligerative | psychiatricDisorder | anxiety | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/12/2008 | 10/06/2009 | Confirmatory | 220862 | 2309 |
1040 | Primary cell-based high-throughput screening assay for antagonists of NPY-Y1 | NPY1R | Neuropeptide Y receptor type 1 | NPY1R | nonProligerative | psychiatricDisorder | anxiety | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/02/2008 | 16/06/2010 | Screening | 196176 | 1984 |
493056 | qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Enhancers | TRHR | Thyrotropin-releasing hormone receptor | TRHR | nonProligerative | psychiatricDisorder | anxiety | [Ca++]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/01/2011 | 20/01/2011 | Screening | 361330 | 2424 |
651719 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) | GALR3 | Galanin receptor type 3 | GALR3_antagonists | nonProligerative | psychiatricDisorder | anxiety | cAMP-coupled CNG channel: MP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2012 | 29/10/2012 | Screening | 357859 | 1562 |
504803 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) | HTRA1 | HTRA1 protein | HTRA1 | nonProligerative | psychiatricDisorder | cerebral arteriopathy with subcortical infarcts and leukoencephalopathy | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/06/2011 | 08/06/2011 | Screening | 343467 | 1710 | ||
574 | Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) | HTR1E | 5-hydroxytryptamine receptor 1E | HTR1E | nonProligerative | psychiatricDisorder | cognitive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/01/2007 | 06/11/2007 | Screening | 64908 | 446 | ||
571 | Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) | HTR1E | 5-hydroxytryptamine receptor 1E | HTR1E | nonProligerative | psychiatricDisorder | cognitive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/01/2007 | 01/11/2007 | Screening | 64908 | 641 | ||
463165 | Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) | RGS4 | Regulator of G-protein signaling 4 | RGS4 | nonProligerative | psychiatricDisorder | cognitive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/08/2010 | 27/08/2010 | Screening | 305610 | 1365 | ||
463111 | Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) | RGS4 | Regulator of G-protein signaling 4 | RGS4 | nonProligerative | psychiatricDisorder | cognitive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/08/2010 | 19/08/2010 | Screening | 305610 | 2820 | ||
624169 | Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) | HTR2A | 5-hydroxytryptamine receptor 2A | HTR2A | nonProligerative | psychiatricDisorder | developmental disorder of mental health | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2012 | 22/05/2012 | Screening | 363803 | 2412 | ||
449768 | High Throughput Screening for Cocaine Antagonists: Primary Screen | SLC6A3 | Sodium-dependent dopamine transporter | SLC6A3 | nonProligerative | psychiatricDisorder | drug addiction | uptake | targetBased | assayID | 2 | prospective analytics successful | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/07/2010 | 23/07/2010 | Screening | 108286 | 1415 |
434989 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) | HCRTR1 | Orexin/Hypocretin receptor type 1 | HCRTR1 | nonProligerative | psychiatricDisorder | insomnia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/06/2010 | 15/06/2010 | Screening | 326024 | 1387 | ||
567 | Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonists | HTR1A | 5-hydroxytryptamine receptor 1A | HTR1A | nonProligerative | psychiatricDisorder | major depressive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/12/2006 | 11/04/2007 | Screening | 64908 | 366 | ||
612 | Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonists | HTR1A | 5-hydroxytryptamine receptor 1A | HTR1A | nonProligerative | psychiatricDisorder | major depressive disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/03/2007 | 11/04/2007 | Screening | 61606 | 416 | ||
488969 | Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening | GRM8 | Glutamate metabotropic receptor 8, Glutamate receptor, metabotropic 8, isoform CRA_a, Metabotropic glutamate receptor 8 | GRM8 | nonProligerative | psychiatricDisorder | mental or behavioural disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2010 | 24/03/2012 | Screening | 105151 | 2166 | ||
2650 | Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha | GSK3A | Glycogen synthase kinase-3 alpha | GSK3A | nonProligerative | psychiatricDisorder | mental or behavioural disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/03/2010 | 31/03/2010 | Screening | 315412 | 318 | ||
1457 | qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium | IMPA1 | Inositol monophosphatase 1 | IMPA1 | nonProligerative | psychiatricDisorder | mental or behavioural disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/12/2008 | 23/12/2008 | Confirmatory | 205582 | 727 | ||
1347165 | Primary screen for KDM5B Histone Demethylases FDH-coupled qHTS | KDM5B | [histone H3]-trimethyl-L-lysine, Lysine-specific demethylase 5B | KDM5B | nonProligerative | psychiatricDisorder | mental or behavioural disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/12/2019 | 06/12/2019 | Confirmatory | 217819 | 5697 | ||
2435 | Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). | OXTR | Oxytocin receptor | OXTR | nonProligerative | psychiatricDisorder | mental or behavioural disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/02/2010 | 15/06/2010 | Screening | 324747 | 1043 | ||
1304 | Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1 | NPY1R | Neuropeptide Y receptor type 1 | NPY1R | nonProligerative | psychiatricDisorder | mental process | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 30/05/2008 | 16/06/2010 | Screening | 217959 | 798 | ||
720711 | qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen | RAPGEF4 | Rap guanine nucleotide exchange factor 4 | RAPGEF4 | nonProligerative | psychiatricDisorder | mental process | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 31/10/2013 | Confirmatory | 364614 | 290 | ||
720708 | qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen | RAPGEF4 | Rap guanine nucleotide exchange factor 4 | RAPGEF4 | nonProligerative | psychiatricDisorder | mental process | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/10/2013 | 31/10/2013 | Confirmatory | 364614 | 663 | ||
492972 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) | PAFAH1B3 | Platelet-activating factor acetylhydrolase IB subunit alpha1 | PAFAH1B3 | nonProligerative | psychiatricDisorder | pervasive developmental disorder | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/12/2010 | 08/12/2010 | Screening | 335239 | 928 | ||
624467 | Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) | TAAR1 | Trace amine-associated receptor 1 | TAAR1 | nonProligerative | psychiatricDisorder | schizophrenia | [Ca++]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/08/2012 | 08/08/2012 | Screening | 362577 | 3573 |
743398 | Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity | Wnt/Beta-catenin pathway | nonProligerative | psychiatricDisorder | schizophrenia | expressionReporter | phenotypic | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/04/2014 | 08/04/2014 | Screening | 304218 | 3630 | ||
504692 | Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) | HTR5A | 5-hydroxytryptamine receptor 5A | HTR5A | nonProligerative | psychiatricDisorder | schizophrenia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/04/2011 | 01/07/2011 | Screening | 335239 | 2035 | ||
504634 | Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) | HTR5A | 5-hydroxytryptamine receptor 5A | HTR5A | nonProligerative | psychiatricDisorder | schizophrenia | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/04/2011 | 03/04/2011 | Screening | 335239 | 279 | ||
720553 | qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS | KCNH2 | Potassium voltage-gated channel subfamily H member 2 , Voltage-gated inwardly rectifying potassium channel KCNH2 | KCNH2 | nonProligerative | psychiatricDisorder | schizophrenia | [Tl+]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/07/2013 | 31/07/2013 | Confirmatory | 342084 | 3260 |
624288 | qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS | GNAS | Guanine nucleotide-binding protein G | GNAS | nonProligerative | rareDiseases | McCune-Albright syndrome (MAS) | cAMP | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/06/2012 | 12/06/2012 | Confirmatory | 337446 | 1356 |
485313 | qHTS Assay for NPC1 Promoter Activators | NPC1 | NPC intracellular cholesterol transporter 1 | NPC1 | nonProligerative | rareDiseases | Niemann Pick Type C (NPC) | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/09/2010 | 04/10/2010 | Confirmatory | 320682 | 7575 |
485297 | qHTS Assay for Rab9 Promoter Activators | RAB9A | Ras-related protein Rab-9A | RAB9A | nonProligerative | rareDiseases | Niemann Pick Type C (NPC) | expressionReporter | phenotypic&targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 29/09/2010 | 29/09/2010 | Confirmatory | 320603 | 9133 |
720511 | Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_SinglePoint_HTS_Activity | CFTR | Cystic fibrosis transmembrane conductance regulator | cftrCorrectors | nonProligerative | rareDiseases | cysticFibrosis | IodineEntry_YFP | targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | 16/07/2013 | 16/07/2013 | Screening | 343786 | 1253 |
602252 | Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_Activity | CFTR | Cystic fibrosis transmembrane conductance regulator | cftrTrafficModulators | nonProligerative | rareDiseases | cysticFibrosis | PPI_FP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 10/02/2012 | 10/02/2012 | Screening | 296501 | 2737 | |
588850 | uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay | NFKB1 | Cystic fibrosis transmembrane conductance regulator | NFKB1 | nonProligerative | rareDiseases | cysticFibrosis | nfkbExpressionReporterGFP | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/12/2011 | 05/12/2011 | Screening | 359244 | 3094 | |
624291 | qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy | CGA | Glycoprotein hormones alpha chain | CGA_integrin_activators | nonProligerative | rareDiseases | muscularDistrophy | expressionReporter | targetBased | TID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/06/2012 | 13/06/2012 | Confirmatory | 345855 | 222 |
1458 | qHTS Assay for Enhancers of SMN2 Splice Variant Expression | SMN1; SMN2 | Survival motor neuron protein | SMN1; SMN2 | nonProligerative | rareDiseases | SMA | expressionReporter | phenotypic&targetBased | TID | 3 | virtual screening, targetID, pathway analysis and repurposing completed | completed | completed | completed | completed | completed | completed | underway | underway | 23/12/2008 | 23/12/2008 | Confirmatory | 208489 | 5817 |
1422 | Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen | PTGER2 | Prostaglandin E2 receptor EP2 subtype | PTGER2 | nonProligerative | reproductiveSystem | male reproductive system disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 31/10/2008 | 31/10/2008 | Screening | 250190 | 1304 | ||
940 | Modulators of the EP2 prostaglandin E2 receptor - Primary Screening | PTGER2 | Prostaglandin E2 receptor EP2 subtype | PTGER2 | nonProligerative | reproductiveSystem | male reproductive system disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/12/2007 | 30/10/2008 | Screening | 255537 | 2141 | ||
624267 | Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | RIPK2 | nonProligerative | reproductiveSystem | male reproductive system disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/06/2012 | 14/06/2012 | Screening | 363803 | 1383 | ||
1565 | uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1 | PHOSPHO1 | Phosphoethanolamine/phosphocholine phosphatase | PHOSPHO1 | nonProligerative | reproductiveSystem | sex hormone-binding globulin measurement | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/03/2009 | 30/12/2010 | Confirmatory | 288321 | 3164 | ||
588590 | qHTS for Inhibitors of Polymerase Iota | POLI | DNA polymerase iota | POLI | nonProligerative | respiratory | lower respiratory tract disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/10/2011 | 20/10/2011 | Confirmatory | 386063 | 3989 | ||
624137 | SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_Activity | ID4 | DNA-binding protein inhibitor ID-4 | ID4 | nonProligerative | respiratory | pulmonary function measurement | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 09/05/2012 | 09/05/2012 | Screening | 31324 | 362 | ||
2006 | uHTS HTRF assay for identification of inhibitors of SUMOylation | UBE2I | SUMO-conjugating enzyme UBC9 | UBE2I | nonProligerative | respiratory | respiratory system disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/10/2009 | 13/01/2011 | Confirmatory | 290915 | 1039 | ||
623877 | Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A) | ANO1 | Anoctamin-1 | ANO1_activators | nonProligerative | respiratory | pulmonary arterial hypertension | [Cl-]i | targetBased | assayID | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/03/2012 | 27/03/2012 | Screening | 335180 | 1022 |
628 | Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen | CHRM1 | Muscarinic acetylcholine receptor M1 | CHRM1_allosteric_antagonists | nonProligerative | respiratory | respiratoryDisorders | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/03/2007 | 29/10/2010 | Screening | 63656 | 2179 | |
588852 | Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) | CHRM1 | Muscarinic acetylcholine receptor M1 | CHRM1_antgonists | nonProligerative | respiratory | respiratoryDisorders | [Ca++]i | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/12/2011 | 09/05/2012 | Screening | 359207 | 4555 | |
775 | Screen for Chemicals that Extend Yeast Lifespan | lifespan | nonProligerative | aging | senescence | yeastDeathReversion | phenotypic | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/07/2007 | 16/11/2007 | Screening | 132777 | 904 | |||
2550 | High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) | TRPC6 | Short transient receptor potential channel 6 | TRPC6 | nonProligerative | urinarySystem | focal segmental glomerulosclerosis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2010 | 25/10/2010 | Screening | 305610 | 382 | ||
2553 | High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) | TRPC6 | Short transient receptor potential channel 6 | TRPC6 | nonProligerative | urinarySystem | focal segmental glomerulosclerosis | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2010 | 21/03/2010 | Screening | 305610 | 3253 | ||
1918 | High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen | KCNJ1 | ATP-sensitive inward rectifier potassium channel 1 , cDNA FLJ76032, highly similar to Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 1 | KCNJ1 | nonProligerative | urinarySystem | renal tubular transport disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/09/2009 | 04/12/2009 | Screening | 125268 | 2463 | ||
485281 | qHTS Assay for Identification of Novel General Anesthetics | FTL | Ferritin light chain | FTL | nonProligerative | visualSystem | eye disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/09/2010 | 27/09/2010 | Confirmatory | 341499 | 255 | ||
360 | Glucocerebrosidase | GBA1 | Lysosomal acid glucosylceramidase | GBA1 | nonProligerative | visualSystem | eye disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/01/2006 | 18/02/2007 | Confirmatory | 48118 | 549 | ||
2071 | Colorimetric Assay for Inhibitors for NALP1 | NLRP1 | NACHT, LRR and PYD domains-containing protein 1 | NLRP1 | nonProligerative | visualSystem | eye disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/10/2009 | 13/01/2011 | Screening | 280024 | 1717 | ||
604 | Primary biochemical high-throughput screening assay for inhibitors of Rho kinase 2 (Rhok2) | ROCK2 | Rho-associated protein kinase 2 | ROCK2 | nonProligerative | visualSystem | eye disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/02/2007 | 11/04/2007 | Screening | 59788 | 212 | ||
488977 | Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) | SLC5A7 | High affinity choline transporter 1 | SLC5A7 | nonProligerative | visualSystem | eye disease | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 01/11/2010 | 14/12/2010 | Screening | 306502 | 1509 | ||
2101 | qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease | GBA | Glucosylceramidase , Lysosomal acid glucosylceramidase | GBA | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/11/2009 | 05/11/2009 | Confirmatory | 321552 | 295 | ||||
2280 | Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. | GLD-1 | Female germline-specific tumor suppressor gld-1 | GLD-1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 21/01/2010 | 10/05/2011 | Screening | 324746 | 1419 | ||||
651636 | uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay | GPR183 | G-protein coupled receptor 183 | GPR183 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2012 | 12/10/2012 | Screening | 363840 | 2946 | ||||
602179 | qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS | HEL-S-26 | Isocitrate dehydrogenase [NADP] , Isocitrate dehydrogenase [NADP] cytoplasmic | HEL-S-26 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/01/2012 | 05/04/2012 | Confirmatory | 387604 | 365 | ||||
493160 | uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) | HKDC1 | Hexokinase HKDC1 | HKDC1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/02/2011 | 08/02/2011 | Screening | 340696 | 540 | ||||
624168 | uHTS identification of small molecule activators of alpha dystroglycan glycosylation | LARGE | Glycosyltransferase-like protein isoform A , Xylosyl- and glucuronyltransferase LARGE1 | LARGE | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 22/05/2012 | 22/05/2012 | Screening | 363840 | 805 | ||||
2016 | Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN. | MEP2 | Ammonium transporter MEP2 | MEP2 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2009 | 05/04/2011 | Screening | 326651 | 1682 | ||||
1832 | MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen | MEX-5 | Zinc finger protein mex-5 | MEX-5 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/06/2009 | 29/09/2009 | Screening | 301788 | 1137 | ||||
588627 | Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling | MGRG2 | Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1 | MGRG2 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/10/2011 | 24/10/2011 | Screening | 306502 | 1351 | ||||
588675 | Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling | MGRG2 | Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1 | MGRG2 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2011 | 25/10/2011 | Screening | 306502 | 1932 | ||||
588676 | Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling | MGRG2 | Mas-related G-protein coupled receptor member X1 , MAS-related GPR, member X1 | MGRG2 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/10/2011 | 25/10/2011 | Screening | 306502 | 3868 | ||||
651718 | Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) | MSRA | Mitochondrial peptide methionine sulfoxide reductase , peptide-methionine | MSRA | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2012 | 29/10/2012 | Screening | 362577 | 2709 | ||||
588352 | Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) | NCOA3 | Nuclear receptor coactivator 3 | NCOA3 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/09/2011 | 31/10/2011 | Screening | 359207 | 620 | ||||
1578 | uHTS luminescence assay for the identification of compounds that inhibit NOD1 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | NOD1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/03/2009 | 30/12/2010 | Confirmatory | 289422 | 2997 | ||||
602438 | uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay | NRP1 | Neuropilin-1 | NRP1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 20/03/2012 | 20/03/2012 | Screening | 363840 | 3086 | ||||
1645870 | Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay | NTMT1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | NTMT1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 27/05/2021 | 27/05/2021 | Confirmatory | 56440 | 1336 | ||||
624263 | A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression | PARK2 | E3 ubiquitin-protein ligase parkin | PARK2 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 05/06/2012 | 05/06/2012 | Confirmatory | 406283 | 823 | ||||
1987 | Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5). | PPP5C | Serine/threonine-protein phosphatase 5 | PPP5C | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/10/2009 | 15/06/2010 | Screening | 314999 | 564 | ||||
2417 | High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment | PTBP1 | Polypyrimidine tract-binding protein 1 | PTBP1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/02/2010 | 24/02/2010 | Screening | 139718 | 4338 | ||||
521 | HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target | PTPN7 | Tyrosine-protein phosphatase non-receptor type 7 | PTPN7 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/11/2006 | 30/08/2010 | Confirmatory | 112381 | 724 | ||||
760 | HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype | RAB2A | Ras-related protein Rab-2A | RAB2A | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 06/07/2007 | 25/10/2009 | Screening | 194628 | 365 | ||||
1515 | Primary biochemical high throughput screening assay to identify inhibitors of Retinoblastoma binding protein 9 (RBBP9) | RBBP9 | Serine hydrolase RBBP9 | RBBP9 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/02/2009 | 16/06/2010 | Screening | 217959 | 445 | ||||
2025 | Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN. | RPL19B | Large ribosomal subunit protein eL19 | RPL19B | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 26/10/2009 | 05/04/2011 | Screening | 325372 | 982 | ||||
588493 | uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay | RPN11 | 26S proteasome non-ATPase regulatory subunit 14 , Testis tissue sperm-binding protein Li 69n | RPN11 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 12/10/2011 | 25/02/2012 | Screening | 359244 | 2134 | ||||
1509 | Primary Cell-Based Assay to Identify Agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) | S1PR4 | Sphingosine 1-phosphate receptor 4 | S1PR4 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/01/2009 | 16/06/2010 | Screening | 217959 | 771 | ||||
1510 | Primary Cell-Based Assay to Identify Antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) | S1PR4 | Sphingosine 1-phosphate receptor 4 | S1PR4 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/01/2009 | 16/06/2010 | Screening | 217959 | 569 | ||||
504775 | HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_Activity | SCARB1 | Scavenger receptor class B member 1 | SCARB1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 25/05/2011 | 25/05/2011 | Screening | 316970 | 306 | ||||
817 | Identification and characterization of compounds for addressing human bone marrow failure | SDO1 | Ribosome maturation protein SDO1 | SDO1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/10/2007 | 03/10/2007 | Other | 138737 | 298 | ||||
434973 | uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) | SENP7 | Sentrin-specific protease 7 , SUMO specific peptidase 7 | SENP7 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/06/2010 | 14/01/2011 | Screening | 331670 | 4902 | ||||
652115 | MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 | SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial | SIRT5 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 15/03/2013 | 15/03/2013 | Screening | 323507 | 3752 | ||||
624304 | uHTS identification of SKN-1 Inhibitors in a fluoresence assay | SKN-1 | Protein skinhead-1 | SKN-1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 19/06/2012 | 15/03/2013 | Screening | 363840 | 1794 | ||||
540253 | qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation | SNUPN | Snurportin-1 | SNUPN | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 14/07/2011 | 14/07/2011 | Confirmatory | 340719 | 242 | ||||
2330 | Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 | STK33 | cDNA FLJ35401 fis, clone SKNSH2005792, highly similar to Serine/threonine-protein kinase 33 , Serine/threonine kinase 33, Serine/threonine kinase 33 , Serine/threonine-protein kinase 33 | STK33 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/02/2010 | 03/02/2010 | Screening | 37341 | 2812 | ||||
2661 | Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity | STK33 | Serine/threonine-protein kinase 33 | STK33 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/03/2010 | 24/03/2010 | Screening | 321808 | 235 | ||||
463195 | uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay | TIM10 | Mitochondrial import inner membrane translocase subunit TIM10 | TIM10 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 03/09/2010 | 25/10/2010 | Screening | 331671 | 4615 | ||||
463190 | uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay | TIM10 | Mitochondrial import inner membrane translocase subunit TIM10 | TIM10 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 02/09/2010 | 07/09/2010 | Screening | 331671 | 7319 | ||||
463212 | uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay | TIM23 | Mitochondrial import inner membrane translocase subunit TIM23 | TIM23 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 07/09/2010 | 07/09/2010 | Screening | 331671 | 4405 | ||||
1443 | uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | TNFSF10 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 08/12/2008 | 04/01/2011 | Screening | 217035 | 883 | ||||
2227 | Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) | TRPC4 | Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4 | TRPC4 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 28/12/2009 | 30/03/2010 | Screening | 305600 | 1291 | ||||
2237 | Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). | TRPC4 | Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4 | TRPC4 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 11/01/2010 | 30/03/2010 | Screening | 305600 | 1510 | ||||
2247 | Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). | TRPC4 | Short transient receptor potential channel 4 , Transient receptor ion channel domain-containing protein, Transient receptor potential cation channel, subfamily C, member 4 | TRPC4 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 13/01/2010 | 30/03/2010 | Screening | 304001 | 1189 | ||||
1424 | Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1) | TRPN1 | Ion channel NompC | TRPN1 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/11/2008 | 04/11/2008 | Screening | 217959 | 390 | ||||
485273 | uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay | UBE2N | Ubiquitin-conjugating enzyme E2 N | UBE2N | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 24/09/2010 | 04/10/2010 | Screening | 330393 | 1538 | ||||
1645856 | USP10 deubiquitinase inhibition: Primary qHTS | USP10 | Ubiquitin carboxyl-terminal hydrolase 10 | USP10 | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 04/05/2021 | 01/07/2021 | Other | 47480 | 509 | ||||
781 | uHTS for 14-3-3/Bad interaction inhibitors | YWHAZ | 14-3-3 protein zeta/delta | YWHAZ | Untagged | targetBased | 1 | records allow Machine Learning | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | notStarted | 23/07/2007 | 23/07/2007 | Screening | 217332 | 1549 |