GLP1R PAM virtual screen. Analogs of reported PAM.

  • GLP1R PAM virtual screen. Analogs of reported PAM.

Among thwe 37k hits identified as potential GLP1R positive allosteric modulators, there are >2.9k molecules that show some similarity with reported GLP1R PAMs. 

 

Here, drTarget will focus on their structures and relevant phenotypic interactions in ChEMBL. 

Structures of reported GLP1R PAMs. Activity score in the top right corner.

The activity of GLP1R PAMs is supported by several references. 

 

compoundtype of activityscoredataInChEmblsourceLiterature
LY3502970agoInLit-pamInChembl7.4YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
CATECHINPAM6YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
VU0453379PAM6.21YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
BETPpamInLit-agoInChembl5.1YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
LSN3160440PAM8.05YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
V-0219PAM7.15YDiscovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”
PhotoETPPAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
N55PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
M_4PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
DA-15864PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
compound19PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
C-1PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
compound20PAM6NNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes
compound2pamInLit-agoInChembl6.52YNon-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes

All these analog compounds show interactions with relevant phenotypes as recorded in ChEMBL DB. 

Interactions graph of reported GLP1R PAM analogs with relevant ChEMBL phenotypes.

Interactions treeMap of reported GLP1R PAM analogs with relevant ChEMBL phenotypes.

Just click on any of the icons below to focus on specific structures and phenotypic interactions associated to any of reported GLP1R PAM classes. 

See LY3502970 similar compounds

See Compound_19 similar compounds

See Compound_20 similar compounds

See DA-15864 & Compound_2 similar compounds

See LSN3160440 similar compounds

See V-0219 similar compounds

See N55 similar compounds

See M_4 similar compounds

See C1 similar compounds

See catechin similar compounds

See VU0453379 similar compounds

See BETP & PhotoETP similar compounds