BrCa target-pathways pairs

Best records from target to pathways annotation. Basically CountRatio>0.7 for targets and 0.6 for pathways.

BestTargetsAndPathways

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TargetName	pathway	organismC	proteinClassDescription	proteinIdentifiedFrom	AvgchemblActivityScoreC	BrCaActivities	TargetAvg(chemblActivityScoreC)	TargetCount(chemblActivityScoreC)	TargetcountRatio	numberOfProteinsWithRecords	pathwayproteinNames	pathwayAvgchemblActivityScoreC	pathwayCountchemblActivityScoreC	pathwaycountRatio	totalNumberOfProteinsInThePathway	rateProteinsWithRecordsVsTotalPathwayProteins	pathwayCountScore

TargetName	pathway	organismC	proteinClassDescription	proteinIdentifiedFrom	AvgchemblActivityScoreC	BrCaActivities	TargetAvg(chemblActivityScoreC)	TargetCount(chemblActivityScoreC)	TargetcountRatio	numberOfProteinsWithRecords	pathwayproteinNames	pathwayAvgchemblActivityScoreC	pathwayCountchemblActivityScoreC	pathwaycountRatio	totalNumberOfProteinsInThePathway	rateProteinsWithRecordsVsTotalPathwayProteins	pathwayCountScore
26S proteosome	ABC-family proteins mediated transport	Homo sapiens	enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified	chemblRecordsActualValues	6.251	Actual	6.251	7220	1	7	26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.309661914	5488.44	1	1370	0.005109489	38419.08
Proteasome Macropain subunit MB1	ABC-family proteins mediated transport	Homo sapiens	enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified	chemblRecordsActualValues	7.703082613	Actual	7.703082613	11	1	7	26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.309661914	5488.44	1	1370	0.005109489	38419.08
Proteasome subunit beta type-7	ABC-family proteins mediated transport	Homo sapiens	enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transporter ntpase atp binding cassette mrp, unclassified	chemblRecordsPrediction	7.698970004	Prediction	7.698970004	8	1	7	26S proteosome, Multidrug resistance-associated protein 7, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.309661914	5488.44	1	1370	0.005109489	38419.08
Histone deacetylase 3	Activation of anterior HOX genes in hindbrain development during early embryogenesis	Homo sapiens	epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv, epigenetic regulator reader brd, epigenetic regulator writer hat p300 cbp, epigenetic regulator writer hat src	chemblRecordsActualValues	5.741160217	Actual	5.741160217	16	0.75	4	CREB-binding protein, Histone deacetylase, Histone deacetylase 3, Nuclear receptor coactivator 3	5.640573077	2601.75	0.65061204	178	0.02247191	10407
Histone deacetylase 1	Activation of E2F1 target genes at G1/S	Homo sapiens	cytosolic other, enzyme kinase protein kinase cmgc cdk cdc2, enzyme, enzyme reductase, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class i, epigenetic regulator eraser hdac hdac class iia, epigenetic regulator eraser hdac hdac class iib, epigenetic regulator eraser hdac hdac class iv	chemblRecordsActualValues	6.143091837	Actual	6.143091837	47	0.85106383	6	CDK2/Cyclin A1, Dihydrofolate reductase, Histone deacetylase, Histone deacetylase (HDAC1 and HDAC2), Histone deacetylase 1, Ribonucleoside-diphosphate reductase M2 chain	5.94374298	1822.166667	0.700171356	37	0.162162162	10933
Toll-like receptor 4/MD-2	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Homo sapiens	membrane receptor, surface antigen	chemblRecordsPrediction	5	Prediction	5	120	1	2	Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14	5	53.4	1	44	0.045454545	106.8
Toll-like receptor 4/MD-2/CD14	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Homo sapiens	membrane receptor, surface antigen	chemblRecordsPrediction	5	Prediction	5	9	1	2	Toll-like receptor 4/MD-2, Toll-like receptor 4/MD-2/CD14	5	53.4	1	44	0.045454545	106.8
26S proteosome	Activation of NF-kappaB in B cells	Homo sapiens	enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified	chemblRecordsActualValues	6.251	Actual	6.251	7220	1	8	26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.246795499	5082.481481	0.959876543	799	0.010012516	40659.85185
Proteasome Macropain subunit MB1	Activation of NF-kappaB in B cells	Homo sapiens	enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified	chemblRecordsActualValues	7.703082613	Actual	7.703082613	11	1	8	26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.246795499	5082.481481	0.959876543	799	0.010012516	40659.85185
Proteasome subunit beta type-7	Activation of NF-kappaB in B cells	Homo sapiens	enzyme hydrolase, enzyme protease threonine pbt t1a, enzyme, enzyme protease threonine pbt t1a, unclassified, transcription factor, unclassified	chemblRecordsPrediction	7.698970004	Prediction	7.698970004	8	1	8	26S proteosome, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Nuclear factor NF-kappa-B p65 subunit, Proteasome Macropain subunit, Proteasome Macropain subunit MB1, Proteasome component C5, Proteasome subunit beta type-7, Proteasome subunit beta type-8	6.246795499	5082.481481	0.959876543	799	0.010012516	40659.85185

Showing 1 to 10 of 416 entries

Selection of Target-pathway pairs with best scoring target parameters.