Molecules interacting with potassium channels

Specificity of interactions of K channels molecules. The graph shows how these molecules hit on all proteins with experimental records in ChEMBL DB. Colors by molecular cluster.

Three molecular clusters (939, 2744, 6191) hit specifically on the KCNA1, KCNA3 & KCNA5 shaker family channels.

Nifedipie, verapamil, clotrimazole, diphenoxylate, sertindole and bergapten show less specific interactions.

See below structures of these compounds

Molecules hitting KCNN, KCNJ, KCNH3 & KCNQ channels

Other clusters also show specific interactions with other potassium channels: ClID_238 for KCNQ1 (Kv7.1, the deafness channel); ClIDs 1654, 1940 and 5091 for the inward rectifiers KCNJ3 &5; ClID_532 and others for the small conductance calcium activated potassium channel KCNN3 (SK3); ClID_2559 for the brain KCNH3 potassium channel.

seeProteinNames

See structures below

Molecules hitting KCNK Channels

Not many compounds and not really specific interactions, but it is worth to highlight that all drugs that inhibit KCNK2 have documented actiovity inhibiting SARS-Cov2.

seeProteinNames

Click to access tio literature references linking KCNK drugs to antiviral activity against SARS-CoV2

Structures of molecules hitting KCNK channels

Click to download csv files with SARS predictions: 64k SARS active compounds, all interactions of active compounds and results aggregated at the target and pathway levels

Molecules interacting with potassium channels

Specificity of interactions of K channels molecules. The graph shows how these molecules hit on all proteins with experimental records in ChEMBL DB. Colors by molecular cluster.

Molecules hitting KCNA Channels

See below structures of these compounds

Molecules hitting KCNN, KCNJ, KCNH3 & KCNQ channels

See structures below

Molecules hitting KCNK Channels

Structures of molecules hitting KCNK channels