drTarget portfolio 2025

drtarget has selected > 800 assays in PubChem suitable to carry out machine learning studies on phenotypic, target-based and pathway-based PChem projects thus enabling virtual screening, target identification, pathways analysis and drug repurposing. 

 

Check drTarget portfolio expansion to > 500 machine learning programs

802 Pubchem assays support 576 machine learning projects associated to 249 diseases corresponding to 29 therapeutic areas. The assays involve > 400 different phenotypes and 461 genes. 

See PubChem assays supporting machine learning programs clicking in the therapeutic area tabs. 

NERVOUS SYSTEM

Nervous system diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps. 

ANTIBACTERIAL

Bacterial diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

IMMUNITY

Immune system diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

ANTIVIRAL

Viral diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

CANCER

Go to different cancer types and assays supporting virtual screens against them. Click to expand treemaps. 

METABOLIC

Nervous system diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

BIOPROCESSES

Bioprocesses treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

CARDIOVASCULAR

Cardiovascular diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

PSYCHIATRIC DISORDERS

Psychiatric diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

RESPIRATORY

Respiratory diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

PROTOZOAN DISEASES

Protozan infections treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

MUSCULOESKELETAL

Musculoeskeletal diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

RARE DISEASES

Rare diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

GENETIC DISORDERS

Genetic disorders treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

OTHER INFECTIOUS DISEASES

Other proliferative diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

OTHER NON PROLIFERATIVE DISEASES

Other non-proliferative diseases treeMap with PubChem assays supporting machine learning on them. Click to expand treemaps.

Find drTarget portfolio details in table. Use scroll bar or search funtion to select specific therapeutic areas, molecular targets or phenotypes. 

PubChemAssayprogramgeneassayTypeareadiseasetestedComopundsactiveCompounds
Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibitionhyphantria cuneaLGR2targetBasedantiArthropodalhyphantria cunea3756481337
11 gram + & - bacterial strains at ChEMBLantibacterialphenotypicantiBacterial11_bacterialStrains
qHTS Assay for Anthrax Lethal Toxin InternalizationBacillus anthracis Lethal Toxin InternalizationphenotypicantiBacterialanthrax68961466
A screen for compounds that inhibit growth of Escherichia coliEscherichia coliphenotypicantiBacterialE. coli327980699
HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_ActivityEscherichia coli ribosomal RNAsphenotypicantiBacterialE. coli3481285500
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTSEscherichia coli ?tolC mutationsphenotypicantiBacterialE. coli650961420
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viabilityHelicobacter pyloriphenotypicantiBacterialH. pylori326024893
High throughput screen for small molecule inhibitors of a hypoxia-regulated fluorescent biosensor in Mycobacterium tuberculosisMycobacterium TuberculosisphenotypicantiBacterialtuberculosis300060312
High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 MediaMycobacterium TuberculosisphenotypicantiBacterialtuberculosis3275581938
High Throughput Screen of 100,000 compound library to Identify Inhibitors of Mycobacterium tuberculosis H37RvMycobacterium tuberculosis H37RvphenotypicantiBacterialtuberculosis1006851594
High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37RvMycobacterium tuberculosis H37RvphenotypicantiBacterialtuberculosis2150982044
Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam AntibioticsMycobacterium Tuberculosis sensitization to betaLactamphenotypicantiBacterialtuberculosis327901876
Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosisMycobacterium tuberculosis, non-replicating, drug-tolerantphenotypicantiBacterialtuberculosis3244331277
Rml C and D inhibition 384-well mixture HTSRmlC_inhibitorsphenotypicantiBacterialtuberculosis106271417
A screen for compounds that inhibit cell wall-associated teichoic acid synthesis in Staphylococcus aureusStaphylococcus aureusphenotypicantiBacterialS. aureus517394434
A screen for compounds that are lethal to S. aureus RN4220Staphylococcus aureus RN4220phenotypicantiBacterialS. aureus3279801062
A screen for compounds that are lethal to S. aureus RN4220 with the processive glycosyltransferase UgtP deletedStaphylococcus aureus RN4220phenotypicantiBacterialS. aureus3279801782
several TB strainsTBphenotypicantiBacterialantibacterials
A screen for compounds that inhibit replication of Vibrio cholerae chromosome IIVibrio cholerae serotype O1AAF95916phenotypicantiBacterialcholera 132441351
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_ActivityVibrio cholerae BH1578 strainphenotypicantiBacterialcholera 349947553
A screen for compounds that inhibit the CapD enzyme of Bacillus anthracisBacillus anthracisCapDtargetBasedantiBacterialanthrax138854320
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound setBacillus anthracis Lethal factor inhibitorsP15917targetBasedantiBacterialanthrax354794422
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)Bacillus subtilisFFPtargetBasedantiBacterialB. subtilis30659910840
qHTS Assay for Activators of ClpPBacillus subtilis (strain 168)CLPPtargetBasedantiBacterialB. subtilis3383786439
PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_ActivityCampylobacter jejuniWLAItargetBasedantiBacterialCampylobacter jejuni355889350
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound setClostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)BOTAtargetBasedantiBacterialbotulism 354794609
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound setClostridium botulinum toxin inhibitorsBoNT/FtargetBasedantiBacterialbotulism 354794780
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary AssaysDiaphoraseInhibitorsDLDtargetBasedantiBacterialClostridium kluyveri1941521342
High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary ScreenEnterococcus faecalis (Streptococcus faecalis)MVAEtargetBasedantiBacterialEnterococcus faecalis194344792
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage)Escherichia coli (strain K12)RECDtargetBasedantiBacterialE. coli362577949
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon)Escherichia coli (strain K12)LONtargetBasedantiBacterialE. coli3620201524
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent)Escherichia coli (strain K12)AMPCtargetBasedantiBacterialE. coli696681256
qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent)Escherichia coli (strain K12)AMPCtargetBasedantiBacterialE. coli3306771730
uHTS identification of MazEF TA System activators via a fluorescence-based single-stranded RNase assayEscherichia coli (strain K12)MAZFtargetBasedantiBacterialE. coli3489231104
A qHTS for Small Molecule Inhibitors of Shiga ToxinEscherichia coli O157:H7STX1targetBasedantiBacterialE. coli29280526874
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga ToxinEscherichia coli O157:H7STX1targetBasedantiBacterialE. coli29561937013
Pyruvate KinaseGeobacillus stearothermophilus (Bacillus stearothermophilus)PYKtargetBasedantiBacterialGeobacillus stearothermophilus51415602
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complexHelicobacter pyloriAddABtargetBasedantiBacterialH. pylori326024935
SSB-PriA antibiotic resistant target AlphaScreenKlebsiella pneumonia SSB-PriA interactionSSBtargetBasedantiBacterialK. pneumonia4312362568
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary AssayLeuconostoc mesenteroidesZWFtargetBasedantiBacterialLeuconostoc mesenteroides195560236
A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosisMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)MENBtargetBasedantiBacterialtuberculosis102628440
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing ActivityMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)RECAtargetBasedantiBacterialtuberculosis2933762191
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosisMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)FBAtargetBasedantiBacterialtuberculosis3592078215
Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU)Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)GLMUtargetBasedantiBacterialtuberculosis215860533
A screen for compounds that inhibit the bacterial siderophore biosynthetic enzyme MbtIMycobacterium tuberculosis (strain CDC 1551 / Oshkosh)MBTItargetBasedantiBacterialtuberculosis104192927
Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_ActivityMycobacterium tuberculosisFadD28targetBasedantiBacterialtuberculosis355054777
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_ActivityMycobacterium tuberculosisBioAtargetBasedantiBacterialtuberculosis353572342
uHTS identification of inhibitors of NadD in a Colorimetric assayNadD_inhibitorsNaMNATtargetBasedantiBacterialS. aureus3620632815
Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamasePseudomonas aeruginosaBLAIMP-1targetBasedantiBacterialP. aeruginosa2907261322
Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_ActivityPseudomonas aeruginosaPvdQtargetBasedantiBacterialP. aeruginosa337500213
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamasePseudomonas aeruginosaBLAVIM-2targetBasedantiBacterialP. aeruginosa2907262575
A small molecule screen for inhibitors of the PhoP regulon in Salmonella TyphimuriumSalmonella TyphiPhoB/PhoRtargetBasedantiBacterialsalmonellosis300458474
A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhiSalmonella TyphimuriumPhoB/PhoRtargetBasedantiBacterialsalmonellosis3059991018
A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureusStaphylococcus aureusLtaStargetBasedantiBacterialS. aureus168223878
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MKStreptococcus PneumoniaeMKtargetBasedantiBacterialS. Pneumoniae65241316
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DCStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)MVADtargetBasedantiBacterialS. Pneumoniae65385320
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - PMKStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)MVAK2targetBasedantiBacterialS. Pneumoniae65392319
MLPCN Streptokinase Expression InhibitionStreptococcus pyogenes serotype M1SKAtargetBasedantiBacterialS. Pneumoniae3034773959
C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_ActivityTcdB glycohydrolaseInhibitorsToxBtargetBasedantiBacterialC. difficile349124837
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing SystemVibrio harveyi (Beneckea harveyi)LUXPtargetBasedantiBacterialluminous vibriosis3021771222
Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_ActivityYersinia pestisSUPXtargetBasedantiBacterialplague356253229
YopH HTSYersinia pestisYopHtargetBasedantiBacterialplague139929223
Phenotypic HTS multiplex for antifungal efflux pump inhibitorsantifungal efflux pumps inhibitorsphenotypicantiFungalfungusGeneral3288971437
Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compoundfluconazole-resistant C.albicansHSP90phenotypicantiFungalcandidiasis3024511736
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_ActivityCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)RTT109targetBasedantiFungalcandidiasis328088521
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1).TPT1TPT1targetBasedantiFungalantifungal3026632452
HTS of Small Molecules that Regulate V-ATPase Proton Transport in Yeast using pHLuorinVMA11VMA11targetBasedantiFungalantifungal3459851287
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12)DAF-12_activatorsDAF-12targetBasedantiHelminthicH. contortus3699535353
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12)DAF-12_activatorsDAF-12targetBasedantiHelminthicS. stercoralis3699533700
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12).DAF-12_activatorsDAF-12targetBasedantiHelminthicH. glycines3699536837
Small Molecules that selectively kill Giardia lamblia: qHTSGiardia lambliaphenotypicantiMicrobialgiardiasis342452530
Leishmania major promastigote HTSLeishmania promastigotephenotypicantiMicrobialleishmaniasis19614117620
NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assayP. Falciparum erythrocyte 3D7phenotypicantiMicrobialmalaria56084205
Inhibition of P. falciparum 3D7P. falciparum 3d7phenotypicantiMicrobialmalaria1345613456
Inhibition of P. falciparum Dd2P. falciparum Dd2phenotypicantiMicrobialmalaria134567921
NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assayP. falciparum erythrocyte W2phenotypicantiMicrobialmalaria56084612
Inhibition of P. falciparum LDHP. falciparum LDHphenotypicantiMicrobialmalaria134560
Calibr Malaria Delayed Death Assay SOPPlasmodium falciparumphenotypicantiMicrobialmalaria37708433
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubationPlasmodium falciparumphenotypicantiMicrobialmalaria30496918055
Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubationPlasmodium falciparumphenotypicantiMicrobialmalaria32320022332
qHTS Primary assay for Inhibitors of Plasmodium falciparum Dd2 growth in vitroPlasmodium falciparumphenotypicantiMicrobialmalaria1236085316
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_ActivityPlasmodium falciparum (isolate 3D7)811941phenotypicantiMicrobialmalaria3365192306
Plasmodium falciparum Dd2 Sybr green parasite growth Measured in Cell-Based and Microorganism Combination System Using Plate ReaderPlasmodium falciparum Dd2phenotypicantiMicrobialmalaria930792144
qHTS of Trypanosoma Brucei InhibitorsT. bruceiTB08.30K1.730phenotypicantiMicrobialtrypanosomiasis406726491
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi ReplicationT. Cruzi replicationphenotypicantiMicrobialchagas3032184394
Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_SinglePoint_HTS_ActivityTrypanosoma cruziphenotypicantiMicrobialtrypanosomiasis765374582
Primary cell-based high-throughput screening assay for identification of small molecule agonists of Aedes aegypti NPYLR7 [Small Molecule Inhibitors of Mosquito Biting Behavior] Inhibitors of Mosquito Biting BehaviorNPYLR7targetBasedantiMicrobialmalaria265113400
HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_ActivityCryptococcus neoformansAKtargetBasedantiMicrobialcryptococcosis357997735
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia LambliaGiardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)FBAtargetBasedantiMicrobialgiardiasis2877382034
qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK)Leishmania mexicanaPYKtargetBasedantiMicrobialleishmaniasis2927321088
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS)met-tRNA synt3662741targetBasedantiMicrobialtrypanosomiasis3638031456
QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1).PFM18AAPinhibitorsCounterscreenCTSL1targetBasedantiMicrobialmalaria3026631482
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assayPlasmodium bergheiG6PD-6PGLtargetBasedantiMicrobialmalaria3489232710
Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).Plasmodium falciparumPf-apPOLtargetBasedantiMicrobialmalaria201181519
qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary ScreenPlasmodium falciparumAMA1-RONtargetBasedantiMicrobialmalaria364096735
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2Plasmodium falciparum (isolate 3D7)811999targetBasedantiMicrobialmalaria307132972
Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP)Plasmodium falciparum (isolate 3D7)M1AAPtargetBasedantiMicrobialmalaria216987913
Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)Plasmodium falciparum (isolate 3D7)LAPtargetBasedantiMicrobialmalaria216988827
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).Plasmodium falciparum (isolate 3D7)M18AAPtargetBasedantiMicrobialmalaria2907263497
qHTS Assay for the Inhibitors of Schistosoma Mansoni PeroxiredoxinsSchistosoma mansoni (Blood fluke)TGRtargetBasedantiMicrobialschistosomiasis35664310735
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1)Trypanosoma brucei bruceiREL1targetBasedantiMicrobialtrypanosomiasis89157438
HTS assay for inhibitors of Trypanosoma brucei hexokinase 1Trypanosoma brucei brucei (strain 927/4 GUTat10.1)3663016targetBasedantiMicrobialtrypanosomiasis220222239
qHTS Assay to Find Inhibitors of T. brucei phosphofructokinaseTrypanosoma brucei brucei (strain 927/4 GUTat10.1)TB03.3K10.320targetBasedantiMicrobialtrypanosomiasis330677557
qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent)Trypanosoma cruziP25779targetBasedantiMicrobialtrypanosomiasis195013848
qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent)Trypanosoma cruziP25779targetBasedantiMicrobialtrypanosomiasis1950134500
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_ActivityPrP_InhibitorsphenotypicantiPrionprionDisease3346341167
PLP&3CLP proteasesPChem screens plus phenotypic records @ ChEMBLSARS-CoVPLP&3CLP proteasespathwayBasedantiViralSARS-CoV
Anti-Viral Drugs Against Arbovirus Infections, a Primary ScreenBluetongue virus (BTV)phenotypicantiViralBTV195407715
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_ActivitydengueVirusphenotypicantiViralDengue3433055946
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_ActivityEpstein-Barr virusLMP1phenotypicantiViralEBV3450642373
High Throughput Screening for Foot and Mouth Disease Virus AntiviralsFoot-and-mouth disease virusphenotypicantiViralFMDV4040625020
qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound libraryFoot-and-mouth disease virusAAA42670phenotypicantiViralFMDV4040631959
qHTS Assay for inhibitors of the human cytomegalovirus (HCMV)HCMV inhibitorsphenotypicantiViralHCMV40325618370
qHTS Assay for Inhibitors of Hepatitis C Virus (HCV)HCV inhibitorsphenotypicantiViralHCV33957311624
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_ActivityHIV fussionphenotypicantiViralHIV3548223866
NCI AIDS Antiviral AssayHIV type 1phenotypicantiViralHIV419761527
qHTS for Inhibitors of binding or entry into cells for Lassa VirusLassa virus entryphenotypicantiViralLassaVirus2971563648
qHTS for inhibitors of binding or entry into cells for Marburg VirusMargburg virus entryphenotypicantiViralMargburg virus2841604700
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library)Measles VirusphenotypicantiViralMeasles1377772077
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_ActivitymiR122_inhibitorsphenotypicantiViralHCV333274472
A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV)Respiratory syncytial virusphenotypicantiViralRSV313719409
qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTSVaccinia virus (VACV)3707576phenotypicantiViralVACV3067371931
qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTSVaccinia virus (VACV)3707576phenotypicantiViralVACV3263631520
A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83Venezuelan equine encephalitis virusphenotypicantiViralVEEV347901453
uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assayAPOBEC3A_inhibitorsAPOBEC3AtargetBasedantiViralHIV3317531372
qHTS for Inhibitors of Vif-A3F Interactions: qHTSAPOBEC3F_inhibitorsAPOBEC3FtargetBasedantiViralHIV383848765
qHTS for Inhibitors of Vif-A3G Interactions: qHTSAPOBEC3G_inhibitorsAPOBEC3GtargetBasedantiViralHIV402348311
uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assayAPOBEC3G_inhibitorsAPOBEC3GtargetBasedantiViralHIV331753931
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrateCrimean-Congo Hemorrhagic Fever (CCHF) virusvOTUtargetBasedantiViralCCHFV3689272045
Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme InhibitionDengue virus type 2P29991targetBasedantiViralDengue3386231013
Counterscreen for inhibitors of EBNA-1: fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of the Epstein-Barr virus-encoded protein, ZTA.Epstein-Barr virusP03206targetBasedantiViralEBV314999485
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1).Epstein-Barr virusBKRF1targetBasedantiViralEBV3026631022
uHTS for Small Molecule Inhibitiors of Epstein-Barr Virus InhibitorsEpstein-Barr virusQ1HVG2targetBasedantiViralEBV218602926
Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Firefly Luciferase SignalFoot-and-mouth disease virusP03308targetBasedantiViralFMDV117258273
Primary qHTS Assay for Foot and Mouth Disease Virus Antivirals against NCGC Sytravon and CBC Compound Libraries: Renilla Luciferase SignalFoot-and-mouth disease virusP03308targetBasedantiViralFMDV117258373
Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID)Hepacivirus hominisNS3targetBasedantiViralHCV290725487
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3)Hepacivirus hominisNS3targetBasedantiViralHCV2907261635
TR-FRET-based primary biochemical high-throughput screening assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerizationHepacivirus hominisABC47431targetBasedantiViralHCV302663998
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSCHIV type 1Hck-NeftargetBasedantiViralHIV2202221495
HIV-1 RNase H InhibitionHIV type 1GAG-POLtargetBasedantiViralHIV99768769
HIV-1 RT-RNase H MLSCN HTS MH077605HIV type 1GAG-POLtargetBasedantiViralHIV652181250
HIV1_TAR : FRET assay measuring displacement of FAM and TAMRA-labeled Tat peptide from HIV-1 TAR RNA.HIV type 1TARtargetBasedantiViralHIV103073615
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_ActivityHIV type 1VIFtargetBasedantiViralHIV3356811162
Primary biochemical high-throughput screening assay for inhibitors of the HIV Rev RRE RNA interaction (disruption of protein-RNA interaction)HIV type 1REVtargetBasedantiViralHIV96879769
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9HIV type 1ENVtargetBasedantiViralHIV3625771546
uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors.HIV type 1ENVtargetBasedantiViralHIV292323890
High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interactionHIV-VIFVIFtargetBasedantiViralHIV2587501498
qHTS Assay for Inhibitors of the HIV-1 protein VprHIV-VPRVPRtargetBasedantiViralHIV361879750
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear EgressHuman cytomegalovirusNEC2targetBasedantiViralHCMV183911278
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_ActivityHuman herpesvirus 8ORF73targetBasedantiViralHHV-8336515262
Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B InteractionHuman herpesvirus 8LANA1targetBasedantiViralHHV-83235641946
Discovery of Small Molecule Probes for H1N1 Influenza NS1AInfluenza A virusNS1targetBasedantiViralH1N13352241010
qHTS Assay for Inhibitors of Influenza NS1 Protein FunctionInfluenza NS1NS1targetBasedantiViralH1N12695611073
A screen for compounds that inhibit viral RNA polymerase binding and polymerization activitiesPoliovirus type 1P03300targetBasedantiViralPoliovirus type 11515251001
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA IntegrationPSIP1PSIP1targetBasedantiViralHIV3699532353
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)SARS-CoVAAZ82016targetBasedantiViralSARS-CoV290726405
qHTS of Yeast-based Assay for SARS-CoV PLPSARS-CoVREPtargetBasedantiViralSARS-CoV328641609
Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagentsSimian virus 40 (SV40)P03070targetBasedantiViralSV403053551203
A screen for compounds that inhibit processive DNA synthesis of vaccinia virusVaccinia virus (VACV)OPG071targetBasedantiViralVACV45651427
uHTS fluorescent assay for identification of inhibitors of ATG4BATG4B_inhibitorsATG4BpathwayBasedbiologicalProcessautophagy3401191734
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity start codon recognitionphenotypicbiologicalProcessgeneRegulation347159450
Human Endothelial Cell Proliferation Assay in 384-well formatangiogenesis_modulatorsphenotypicbiologicalProcessangiogenesis86159925
Human Lung Fibroblast Proliferation Assayangiogenesis_modulators_secondaryphenotypicbiologicalProcessangiogenesis84879937
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activatorsaSynucleinExpressionActivatorsphenotypicbiologicalProcesssynucleinEffect30380121690
High-content cell-based screening for modulators of autophagyautophagy imaging assayphenotypicbiologicalProcessautophagy1945281903
qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Regioncaspase1InhibitorsphenotypicbiologicalProcessapoptosisInhibition73912779
cell growth assays at ChEMBLcytotoxphenotypicbiologicalProcesscytotoxicity
HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules.DyneinTransportphenotypicbiologicalProcessproteinTransport2199021036
Quantitative High-Throughput Screen for Regulators of Epigenetic ControlEpigeneticControlphenotypicbiologicalProcessEpigeneticControl272097537
Screen for Chemicals that Extend Yeast LifespanlifespanphenotypicbiologicalProcesssenescence132777904
Screen for Chemicals that Shorten Yeast LifespanlifespanphenotypicbiologicalProcesstoolCompounds138737710
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary ScreenmitochondrialFusionphenotypicbiologicalProcessmitochondrialFusion1941534011
qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial FusionmitochondrialFusionphenotypicbiologicalProcessmitochondrialFusion322166738
Modulators of Post-Golgi TransportModulators of Post-Golgi TransportphenotypicbiologicalProcesssecretionPath97509875
Screening for Modulators of Post-Golgi Transport, Control StrainModulators of Post-Golgi TransportphenotypicbiologicalProcesssecretionPath975184851
HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells.necrosisByCaspaseInhibitorsphenotypicbiologicalProcessnecrosis217101832
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_ActivityPGC1aActivatorsphenotypicbiologicalProcessOxidative Metabolic Function345870740
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_ActivityPGC1aInhibitorsphenotypicbiologicalProcessOxidative Metabolic Function345870601
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complexRanGTP-Importin-beta complex inhibitorsphenotypicbiologicalProcesscellDivision3023873282
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtypeRAS_inhibitorsphenotypicbiologicalProcessRAS_pathways194628398
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301SUMOylationInhibitorsphenotypicbiologicalProcessSUMOylation3184583322
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxidesuperoxideGenerationInhibitorsphenotypicbiologicalProcessaging328830590
Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound SetABCB6_inhibitorsABCB6targetBasedbiologicalProcessdrugTransport362098692
uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphataseALPI_inhibitorsALPItargetBasedbiologicalProcessalcalinePhosphatase330392393
uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphataseALPI_inhibitorsALPItargetBasedbiologicalProcessalcalinePhosphatase331670664
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1)ASAP1_inhibitorsASAP1targetBasedbiologicalProcessprospectiveBiology362577680
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1BCL2A1_modulatorsBCL2A1targetBasedbiologicalProcessapoptosis194826237
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL).BCL2L1_modulatorsBCL2L1targetBasedbiologicalProcessapoptosis3149982199
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis.BCL2L11_inhibitorsBCL2L11targetBasedbiologicalProcessapoptosis325630216
High Throughput Imaging Assay for Beta-CateninbetaCateninTranslocationCTNNB1targetBasedbiologicalProcessdementia193542587
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5CHRM5targetBasedbiologicalProcessM4_AcChBiology363803698
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5CHRM5targetBasedbiologicalProcessM4_AcChBiology3638032133
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5)CHRM5CHRM5targetBasedbiologicalProcessM4_AcChBiology3638031081
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assayCOPS5COPS5targetBasedbiologicalProcessUbiquitination 3638401401
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complexCRHBP_agonistsCRHBPtargetBasedbiologicalProcesstoolCompounds3489231622
uHTS Colorimetric assay for identification of inhibitors of Scp-1CTDSP1_inhibitorsCTDSP1targetBasedbiologicalProcessnervousSystemDevelopment3406962986
HTS Assay for Activators of Cytochrome P450 2A9CYP2C9_activatorsCYP2C9targetBasedbiologicalProcesscytochromesRoles958581368
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB)DAGLB_inhibitorsDAGLBtargetBasedbiologicalProcessendocannabinoidSignaling343468202
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stressDDIT3_inhibitorsDDIT3targetBasedbiologicalProcessapoptosis2186548241
uHTS for Small Molecule Inhibitors of Eukaryotic Translation InitiationEIF4E_inhibitionEIF4EtargetBasedbiologicalProcessautophagy217332799
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_ActivityHSF1_activatorsHSF1targetBasedbiologicalProcessstressResponse3011705173
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9KCNK9_blockersKCNK9targetBasedbiologicalProcesstoolCompounds3056103794
qHTS Assay for Inhibitors of JMJD2A-Tudor DomainKDM4AKDM4AtargetBasedbiologicalProcessepigenetics38452716920
Primary cell-based high-throughput screening assay to measure PERK inhibitionPERK_inhibitorsEIF2AK3targetBasedbiologicalProcessproteinMisfolding217959370
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1).PLCG1PLCG1targetBasedbiologicalProcesstoolCompoundsMultiDiseases3699533123
Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3procaspase3ActivatorsCASP3targetBasedbiologicalProcessapoptosis326024350
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_ActivitySCARB1SCARB1targetBasedbiologicalProcessLipid transport3192043065
qHTS Assay to Identify Small Molecule Activators of BRCA1 ExpressionBRCA1 activationBRCA1pathwayBasedcancerbreastCancer3760293978
HTS to identify compounds that promote myeloid differentiation with MLPCN compound setHOXA9HOXA9pathwayBasedcancerleukemia3585563721
qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening AssayMAPK1MAPK1pathwayBasedcancerneoplastic disease or syndrome70898707
qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGFMAPK1MAPK1pathwayBasedcancerneoplastic disease or syndrome131324544
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN.mTOR_pathwayModulatorsCIT2pathwayBasedcancercancerGeneral321534210
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN.mTOR_pathwayModulatorsAPE1pathwayBasedcancercancerGeneral3247341090
qHTS assay for re-activators of p53 using a Luc reporterTP53TP53pathwayBasedcancercancerGeneral321427201
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction Disrupters of an Hsp90 Co-Chaperone InteractionphenotypiccancercancerGeneral69668300
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity EWS/Fli transcriptional activity inhibitorsphenotypiccancerEwingSarcoma3422362318
8 cell line screens at ChEMBLBrCa cell linesphenotypiccancerbreastCancer
avg of cell line screens at ChEMBLBrCaAvgphenotypiccancerbreastCancer
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell linebreastCancerphenotypiccancerbreastCancer372322330
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell linebreastCancerphenotypiccancerbreastCancer716552694
NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell linebreastCancerphenotypiccancerbreastCancer385022659
NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell linebreastCancerphenotypiccancerbreastCancer718412560
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell linebreastCancerphenotypiccancerbreastCancer404004425
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell linebreastCancerphenotypiccancerbreastCancer759814212
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell linebreastCancerphenotypiccancerbreastCancer400902464
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-231/ATCC Breast cell linebreastCancerphenotypiccancerbreastCancer747063330
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell linebreastCancerphenotypiccancerbreastCancer401933548
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell linebreastCancerphenotypiccancerbreastCancer750715500
NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell linebreastCancerphenotypiccancerbreastCancer407792492
NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell linebreastCancerphenotypiccancerbreastCancer749722944
NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell linebreastCancerphenotypiccancerbreastCancer381482490
NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell linebreastCancerphenotypiccancerbreastCancer727673276
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem CellsbreastCancerStemCellsCadherinNullphenotypiccancerbreastCancer3006213187
NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor529312856
NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor752892115
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor532053526
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor723533611
NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor505113547
NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor745204513
NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor527782515
NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor742081576
NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor496853444
NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor730933359
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell lineCNS_tumorphenotypiccancerCNS_tumor532113544
9 cell line screens at ChEMBLCoCa cell linesphenotypiccancercolonCancer
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell linecolonCancerphenotypiccancercolonCancer527123480
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell linecolonCancerphenotypiccancercolonCancer727434943
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell linecolonCancerphenotypiccancercolonCancer484212752
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell linecolonCancerphenotypiccancercolonCancer728523007
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell linecolonCancerphenotypiccancercolonCancer527274422
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell linecolonCancerphenotypiccancercolonCancer755515013
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell linecolonCancerphenotypiccancercolonCancer530503475
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell linecolonCancerphenotypiccancercolonCancer755303437
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell linecolonCancerphenotypiccancercolonCancer528443773
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell linecolonCancerphenotypiccancercolonCancer746885101
NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell linecolonCancerphenotypiccancercolonCancer531043462
NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell linecolonCancerphenotypiccancercolonCancer752183369
NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell linecolonCancerphenotypiccancercolonCancer535084024
NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell linecolonCancerphenotypiccancercolonCancer753273576
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin ExpressioncolonCancerNotExpressingOncogenicBetaCateninphenotypiccancercolonCancer1387372051
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor SuppressorcolonCancerwithPtenDeletionphenotypiccancercolonCancer1384171658
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell lineglioblastomaphenotypiccancerglioblastoma731843470
qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell linegliomaWithIdh1Mutationsphenotypiccancerglioma3644647438
Isolation of Inhibitors of Her-Kinase Expression - 66K library screenHer-Kinase ExpressionphenotypiccancercancerGeneral64629448
uHTS identification of small molecule inhibitors of TWEAK-Fn14 interactions, using a cell-based reporter assayinhibitors of TWEAK-Fn14 interactionsphenotypiccancerglioblastoma3620637302
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineleukemiaphenotypiccancerleukemia505805047
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineleukemiaphenotypiccancerleukemia704894627
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell lineleukemiaphenotypiccancerleukemia716755995
NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell lineleukemiaphenotypiccancerleukemia518554709
NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell lineleukemiaphenotypiccancerleukemia718804980
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell lineleukemiaphenotypiccancerleukemia522194310
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell lineleukemiaphenotypiccancerleukemia737774676
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell lineleukemiaphenotypiccancerleukemia497814206
NCI human tumor cell line growth inhibition assay. Data for the RPMI-8226 Leukemia cell lineleukemiaphenotypiccancerleukemia707804886
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell lineleukemiaphenotypiccancerleukemia443075398
NCI human tumor cell line growth inhibition assay. Data for the SR Leukemia cell lineleukemiaphenotypiccancerleukemia671135428
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) miceleukemiaphenotypiccancerleukemia557411560
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) miceleukemiaphenotypiccancerleukemia445272353
11 cell line screens at ChEMBLLuCa cell linesphenotypiccancerlungCancer
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell linemelanomaphenotypiccancermelanoma500803993
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell linemelanomaphenotypiccancermelanoma734624776
NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell linemelanomaphenotypiccancermelanoma522573432
NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell linemelanomaphenotypiccancermelanoma739684221
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell linemelanomaphenotypiccancermelanoma494162812
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell linemelanomaphenotypiccancermelanoma718823760
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell linemelanomaphenotypiccancermelanoma502952412
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell linemelanomaphenotypiccancermelanoma709392926
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell linemelanomaphenotypiccancermelanoma525931983
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell linemelanomaphenotypiccancermelanoma748692694
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell linemelanomaphenotypiccancermelanoma524383585
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell linemelanomaphenotypiccancermelanoma733274240
NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell linemelanomaphenotypiccancermelanoma527172210
NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell linemelanomaphenotypiccancermelanoma717972912
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell linemelanomaphenotypiccancermelanoma523993598
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell linemelanomaphenotypiccancermelanoma747823675
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_ActivitymiR122_activatorsphenotypiccancerhepatocellularCarcinoma3332741022
qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21miRNA_modulatorsphenotypiccancercancerGeneral3335103282
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_ActivityMITF_expressionEnhancersphenotypiccancermelanoma3008452272
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2NLG_inhibitorsphenotypiccancercancerGeneral358025830
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma535602992
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma743862485
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma508202137
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma643891626
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma520012981
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma736432556
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma475373298
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma651893616
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma495642467
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma723752184
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma532143094
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma750102580
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma520462317
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma730501747
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma520334098
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma752114608
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell linenonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma489874260
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line, single concentrationnonSmallCellLungCarcinomaphenotypiccancernonSmallCellLungCarcinoma712755229
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer728673166
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer526093249
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer748644915
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer519833749
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer730882443
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer509692336
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer750041854
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-5 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer525022104
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer745862891
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-8 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer534263114
NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer732972087
NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell lineovarianCancerphenotypiccancerovarianCancer510812532
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assayPERK-elF2a-CHOP pathway activatorsphenotypiccancercancerGeneral3316711124
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell lineprostateCancerphenotypiccancerprostateCancer747762861
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell lineprostateCancerphenotypiccancerprostateCancer405982824
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell lineprostateCancerphenotypiccancerprostateCancer737002603
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell lineprostateCancerphenotypiccancerprostateCancer404983034
Screen for Chemicals that Inhibit the RAM NetworkRAM network inhibitorsphenotypiccancercancerGeneral1945503545
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell linerenalCancerphenotypiccancerrenalCancer746883319
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell linerenalCancerphenotypiccancerrenalCancer524283081
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell linerenalCancerphenotypiccancerrenalCancer698513516
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell linerenalCancerphenotypiccancerrenalCancer470903449
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell linerenalCancerphenotypiccancerrenalCancer745453244
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell linerenalCancerphenotypiccancerrenalCancer528943233
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell linerenalCancerphenotypiccancerrenalCancer683222874
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell linerenalCancerphenotypiccancerrenalCancer501883283
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell linerenalCancerphenotypiccancerleukemia484264751
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell linerenalCancerphenotypiccancerrenalCancer712154339
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell linerenalCancerphenotypiccancerrenalCancer480613402
NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell linerenalCancerphenotypiccancerrenalCancer747082495
NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell linerenalCancerphenotypiccancerrenalCancer529673005
NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell linerenalCancerphenotypiccancerrenalCancer744452716
NCI human tumor cell line growth inhibition assay. Data for the TK-10 Renal cell linerenalCancerphenotypiccancerrenalCancer520471986
NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell linerenalCancerphenotypiccancerrenalCancer746773544
NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell linerenalCancerphenotypiccancerrenalCancer527262935
Screen for inhibitors of RMI FANCM (MM2) intereactionRMI FANCM intereactionphenotypiccancercancerGeneral69794402
Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_ActivityrosLevelsphenotypiccancercancerGeneral45939901
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K ScreensmallCellLungCarcinomaCellLineExpressingTransportDetoxProtMDR1phenotypiccancersmallCellLungCarcinoma852005142
Inhibitor identification of TROY dependent signaling using uHTS single point assayTROY_signalling_inhibitorsphenotypiccancercancerGeneral3606573551
NCI Yeast Anticancer Drug Screen. Data for the bub3 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair805049618
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair804988083
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair811338837
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair8111210175
NCI Yeast Anticancer Drug Screen. Data for the rad50 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair811339814
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strainyeastScreenWithAlterationsInDnaRepairphenotypiccancercancerWithAlterationsInDnaRepair804989555
AlphaScreen-based biochemical high throughput primary assay to identify activators of the E3 ligase (FBW7). E3 ligase activatorsFBW7targetBasedcancercancerGeneral641445853
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl)ABL1_interactionABL1targetBasedcancerleukemia3592071432
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10.ADAM10_inhibitorsADAM10targetBasedcancerbreastCancer3699532294
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17.ADAM17_inhibitorsADAM17targetBasedcancerbreastCancer3699533080
HTS Assay for Inhibitors of Akt Phophorylation: Primary ScreenAKT1_inhibitorsAKT1targetBasedcancercancerGeneral3565171139
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2ALOX12_inhibitorsALOX12targetBasedcancercancerGeneral5642886030
qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2)ALOX15B_inhibitorsALOX15BtargetBasedcancercancerGeneral107252595
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSALR inhibitorsGFERtargetBasedcancercancer28872810857
uHTS Fluorescent assay for identification of activators of Apaf-1APAF1_activatorsAPAF1targetBasedcancercancerGeneral3316711041
qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)APEX1_inhibitorsAPEX1targetBasedcancercancerGeneral3458981172
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assayAPLNR_antagonistsAPLNRtargetBasedcancercancerGeneral3303921062
Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction That Mediate GPCR Degradation and RecyclingARRB1_inhibitorsARRB1targetBasedcancercancerGeneral3383731061
uHTS identification of small molecule inhibitors of Artemis endonuclease activity via a fluorescence intensity assayartemis_inhibitorsDCLRE1CtargetBasedcanceracuteLymphoblasticLymphoma30104235
qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1ATAD5_inhibitorsATAD5targetBasedcancercancerGeneral3301094174
qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1ATAD5_inhibitorsATAD5targetBasedcancercancerGeneral3301077652
HTS for BAP1 Enzyme inhibitorsBAP1_inhibitorsBAP1targetBasedcancercancerGeneral71016346
qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM)BLM_inhibitorsBLMtargetBasedcancercancerGeneral347933673
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assayCCR6_antagonistsCCR6targetBasedcancermetastasis3406961654
Identification of CBX7 inhibitors - Primary Alpha ScreenChromobox protein homolog 7 inhibitorsCBX7targetBasedcancercancerGeneral64999724
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assayCXCR6_inhibitorsCXCR6targetBasedcancermetastasis3620631298
Dicer-mediated maturation of pre-microRNADicer_inhibitorsDICER1targetBasedcancercancerGeneral467152829
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assayDNMT1DNMT1targetBasedcancercancerGeneral3592442975
qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9aEHMT2_inhibitorsEHMT2targetBasedcancercancerGeneral34833830875
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)EIF4HEIF4HtargetBasedcancercancerGeneral2909152744
HTS of Estrogen Receptor- alpha Coactivator Binding inhibitorsESR1_inhibitorsESR1targetBasedcancerbreastCancer860951442
HTS for Estrogen Receptor-beta Coactivator Binding inhibitorsESR2_inhibitorsESR2targetBasedcancerbreastCancer860951114
EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_ActivityEZH2_inhibitorsEZH2targetBasedcancercancerGeneral57013201
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assayFASN_inhibitorsFASNtargetBasedcancercancerGeneral3620632427
Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_ActivityFGF22_inhibitorsFGF22targetBasedcancerneoplastic disease or syndrome3396505128
Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2)GALR2GALR2targetBasedcancerneoplastic disease or syndrome140088678
Primary cell-based high-throughput screening assay to identify antagonists of Galanin Receptor 2 (GALR2)GALR2_antagonistsGALR2targetBasedcancerneoplastic disease or syndrome140088548
qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell linegliomaWithIdh1MutationsHEL-S-26targetBasedcancerglioma3644645966
qHTS for Agonists of Human Resolvin D1 Receptor DRV1GPR32GPR32targetBasedcancerneoplastic disease or syndrome474731217
Image-Based HTS for Selective Antagonists for GPR55GPR55GPR55targetBasedcancerneoplastic disease or syndrome291657370
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of Histone Deacetylase 3HDAC3HDAC3targetBasedcancerneoplastic disease or syndrome318291483
uHTS identification of HIF-2a Inhibitors in a luminesence assayHIF-2a_inhibitorsEPAS1targetBasedcancercancerGeneral3638402624
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtypeHRASHRAStargetBasedcancerneoplastic disease or syndrome194628267
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1).HSF1HSF1targetBasedcancerneoplastic disease or syndrome3013242328
HTS for Tumor Hsp90 InhibitorsHSP90 known inhibitor displacementHSP90AA1targetBasedcancercancerGeneral63696220
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90)HSP90AA1HSP90AA1targetBasedcancercancerGeneral2907262649
qHTS of IL-2 ActivatorsIL2IL2targetBasedcancerneoplasm of thorax364617238
Inhibitors of CDC25B-CDK2/CyclinA interactionInhibitors of CDC25B-CDK2/CyclinA interactionCCNA2targetBasedcancercancerGeneral93798679
Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617FJAK2JAK2targetBasedcancerneoplastic disease or syndrome2179592390
qHTS Assay for Inhibitors of GCN5L2KAT2AKAT2AtargetBasedcancerneoplastic disease or syndrome381571792
qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E)KDM4EKDM4EtargetBasedcancerneoplastic disease or syndrome2269143523
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_ActivityKEAP1KEAP1targetBasedcancerneoplastic disease or syndrome336894489
Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5)KLF5KLF5targetBasedcancerneoplastic disease or syndrome290726671
Kallikrein 5 1536 HTSKLK5KLK5targetBasedcancerneoplastic disease or syndrome2141871264
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogenKLK7KLK7targetBasedcancerneoplastic disease or syndrome3689273325
qHTS Assay for the Inhibitors of L3MBTL1L3MBTL1L3MBTL1targetBasedcancerneoplastic disease or syndrome2253091492
qHTS assay for inhibitors of human lactate dehydrogenaselactateDehydrogenaseInhibitorsLDHAtargetBasedcancercancerGeneral476056732
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 1 (LYPLA1).LYPLA1LYPLA1targetBasedcancerneoplastic disease or syndrome314999499
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 WildtypeMAP3K3MAP3K3targetBasedcancerneoplastic disease or syndrome2895734159
Primary biochemical high-throughput screening assay for inhibitors of the c-Jun N-Terminal Kinase 3 (JNK3)MAPK10MAPK10targetBasedcancerneoplastic disease or syndrome59788366
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotideMBD2MBD2targetBasedcancerReactivate the silenced genes in cancer cells3699531149
E3 Ligase HTS_1536MDM2MDM2targetBasedcancerneoplastic disease or syndrome207811220
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format.MDM4MDM4targetBasedcancerneoplastic disease or syndrome33167110022
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1MDR1-selective compoundsABCB1targetBasedcancercancerGeneral39602913426
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1MDR1-selective compoundsABCB1targetBasedcancercancerGeneral3959815516
qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant PeptideMenin-MLL_inhibitorsMEN1targetBasedcancerleukemia263421615
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_ActivityMITFMITFtargetBasedcancerneoplastic disease or syndrome3313602760
AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of microphthalmia-associated transcription factor (MITF)MITF inhibitorsMITFtargetBasedcancermelanoma6423625830
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_ActivityMLLT3MLLT3targetBasedcancerneoplastic disease or syndrome3444591627
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1)NCOA1NCOA1targetBasedcancerneoplastic disease or syndrome359206428
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2)NCOA2NCOA2targetBasedcancerneoplastic disease or syndrome368927620
qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive TemperaturenonSmallCellLungCarcinomaWithP53MutationsTP53targetBasedcancernonSmallCellLungCarcinoma54509528
qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive TemperaturenonSmallCellLungCarcinomaWithP53MutationsTP53targetBasedcancernonSmallCellLungCarcinoma54513338
qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive TemperaturenonSmallCellLungCarcinomaWithP53MutationsTP53targetBasedcancernonSmallCellLungCarcinoma1253941890
qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive TemperaturenonSmallCellLungCarcinomaWithP53MutationsTP53targetBasedcancernonSmallCellLungCarcinoma1240221156
Primary cell based high-throughput screening assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2)NPY2RNPY2RtargetBasedcancerneoplastic disease or syndrome1400881384
Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2NPY2RNPY2RtargetBasedcancerneoplastic disease or syndrome217959969
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2)NR5A2NR5A2targetBasedcancerneoplastic disease or syndrome363803458
Nrf2 qHTS screen for inhibitorsnrf2InhibitorsNFE2L2targetBasedcancercancerGeneral3608737438
Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2NSD2NSD2targetBasedcancerneoplastic disease or syndrome3096841662
Image-Based HTS for Selective Agonists for NTR1NTSR1NTSR1targetBasedcancerneoplastic disease or syndrome331753556
uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assayOPRK1OPRK1targetBasedcancerneoplastic disease or syndrome290355265
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptorsOPRM1OPRM1targetBasedcancerneoplastic disease or syndrome335239991
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptorsOPRM1OPRM1targetBasedcancerneoplastic disease or syndrome335239695
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)PABPC1PABPC1targetBasedcancerneoplastic disease or syndrome2909152982
uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assayPABPC1PABPC1targetBasedcancerneoplastic disease or syndrome3592441307
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)PLA2G3PLA2G3targetBasedcancerneoplastic disease or syndrome3699532089
qHTS for Inhibitors of Polymerase KappaPOLKPOLKtargetBasedcancerneoplastic disease or syndrome3952952034
HTS Assay for Peg3 Promoter InhibitorsPPP1R15APPP1R15AtargetBasedcancercancerGeneral3592446145
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complexPRKAR1APRKAR1AtargetBasedcancerneoplastic disease or syndrome343468285
Antagonist identification of Pyk2 oligomerization: high-throughput screening cellular assayPyk2 PTK2BtargetBasedcancercancerGeneral98749818
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutantRAC1RAC1targetBasedcancerneoplastic disease or syndrome194629219
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtypeRAC1RAC1targetBasedcancerneoplastic disease or syndrome194628521
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_ActivityRAD54LRAD54LtargetBasedcancerneoplastic disease or syndrome358498505
ROC1-CUL1 CTD Inhibitor di-Ub FRET Primary HTS ScreenRBX1RBX1targetBasedcancerneoplastic disease or syndrome143816859
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting EnzymeRCE1RCE1targetBasedcancerneoplastic disease or syndrome294698799
qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)RECQLRECQLtargetBasedcancerneoplastic disease or syndrome2349151245
qHTS Assay for Antagonists of the Relaxin Receptor RXFP1relaxinInhibitorsRXFP1targetBasedcancercancerGeneral3501772058
uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb via a fluorescence resonance energy transfer (FRET) assay.RUNX1RUNX1targetBasedcancerneoplastic disease or syndrome215667993
uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay.RUNX1RUNX1targetBasedcancerneoplastic disease or syndrome2182341620
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_ActivitySELESELEtargetBasedcancerneoplastic disease or syndrome257988963
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8)SENP8SENP8targetBasedcancerneoplastic disease or syndrome3303924119
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8)SENP8SENP8targetBasedcancerneoplastic disease or syndrome3638402341
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_ActivitySMARCA4SMARCA4targetBasedcancerneoplastic disease or syndrome3447337043
uHTS identification of SUMO1-mediated protein-protein interactionsSUMO1SUMO1targetBasedcancerresistanecToRadiation3638401202
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_ActivityTACC3TACC3targetBasedcancerneoplastic disease or syndrome3911792589
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assayTNFRSF10BTNFRSF10BtargetBasedcancerneoplastic disease or syndrome3638403764
qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTSTXNRD1TXNRD1targetBasedcancerneoplastic disease or syndrome3866633977
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assayUBE2MUBE2MtargetBasedcancerneoplastic disease or syndrome3638402123
AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of Unc-51 Like Autophagy Activating Kinase 1 (ULK1).ULK1ULK1targetBasedcancercancerGeneral30185575
USP8 deubiquitinase inhibition: Primary qHTSUSP8USP8targetBasedcancerneoplastic disease or syndrome474802010
HTS Colorimetric assay for the identification of compounds that inhibit VHR1VHR1_inhibitorsDUSP3targetBasedcancercancerGeneral49813347
uHTS absorbance assay for the identification of compounds that inhibit VHR1.VHR1_inhibitorsDUSP3targetBasedcancercancerGeneral2910061524
qHTS for Inhibitors of WRN HelicaseWRNWRNtargetBasedcancerneoplastic disease or syndrome3640111678
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activityGC-A_PAMsphenotypiccardioVascularhypertension370293519
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activityGC-B_PAMsphenotypiccardioVascularmyocardialFibrosis370293399
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor PathwayHIF_expressionActivatorsphenotypiccardioVascularischemia300341950
uHTS identification of small molecule modulators of myocardial damagemyocardial damagephenotypiccardioVascularmyocardial infarction3592442272
uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assayAPLNR_agonistsAPLNRtargetBasedcardioVascularhypertension330348347
HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_ActivityCACNA1D_inhibitorsCACNA1DtargetBasedcardioVascularhypertension335531328
Factor XIa 1536 HTSF11_modulationF11targetBasedcardioVascularantithrombotic 218707302
Factor XIIa 1536 HTSF12_modulationF12targetBasedcardioVascularantithrombotic 217430649
Thrombin 1536 HTSF2_modulationF2targetBasedcardioVascularantithrombotic 217233557
Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agentsKCNH2KCNH2targetBasedcardioVascularRare genetic cardiac disease3056101552
qHTS for Inhibitors of KCHN2 3.1: Wildtype qHTSKCNH2KCNH2targetBasedcardioVascularRare genetic cardiac disease3436661267
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3KCNK3KCNK3targetBasedcardioVasculararterial disorder3396742841
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channelsKCNQ1KCNQ1targetBasedcardioVascularcongenital heart disease3056103878
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channelsKCNQ1KCNQ1targetBasedcardioVascularcongenital heart disease3056101082
Natriuretic polypeptide receptor (hNpr1) antagonism - Primary qHTSNPR1NPR1targetBasedcardioVascularcongestive heart failure761681231
Novel sEH inhibitors for the therapeutic treatment of hypertension and inflammationsEH_inhibitorsEPHX2targetBasedcardioVascularhypertension90640310
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assayIRE1-XBP1 pathway activatorsphenotypiccytoprotectioncellRecovery3316711099
HTS for developing T Cell Immune ModulatorsITGALITGALtargetBaseddermatologyskin disease326271221
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH)PLA2G7PLA2G7targetBaseddermatologyskin disease3260244934
HCS assay for microtubule stabilizersTUBBTUBBtargetBaseddermatologyskin disease1958211625
HTS for Identification of VLA-4 Allosteric Modulators from MLPCN libraryITGA4ITGA4targetBasedgastroIntestinalintestinal disease326888645
OTUD3 deubiquitinase inhibition: Primary qHTSOTUD3OTUD3targetBasedgastroIntestinalintestinal disease47480334
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activityRORCRORCtargetBasedgastroIntestinalintestinal disease30406010600
Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: SytravonMTORMTORpathwayBasedgeneticDisorderdevelopmental defect during embryogenesis43989342
Identification of Molecular Probes that Activate MRP-1ABCC1_activatorsABCC1targetBasedgeneticDisorderPseudoxanthoma elasticum 138717842
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the serine hydrolase family member Fam108B.ABHD17BABHD17BtargetBasedgeneticDisordergenetic, familial or congenital disease302663993
qHTS for Inhibitors of Glutaminase (GLS)GLSGLStargetBasedgeneticDisorderautosomal recessive disease405291844
High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunitsGNAI3GNAI3targetBasedgeneticDisorderear malformation204125876
qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II)HSD17B10HSD17B10targetBasedgeneticDisorderdevelopmental defect during embryogenesis720722464
qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4HSD17B10HSD17B10targetBasedgeneticDisorderdevelopmental defect during embryogenesis739125649
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1)MCOLN1MCOLN1targetBasedgeneticDisorderdevelopmental defect during embryogenesis400814482
Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1)NR5A1NR5A1targetBasedgeneticDisorderdevelopmental defect during embryogenesis649081225
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1)NR5A1NR5A1targetBasedgeneticDisorderdevelopmental defect during embryogenesis64908359
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3).PLCB3PLCB3targetBasedgeneticDisorderspondylometaphyseal dysplasia with corneal dystrophy369953662
Cell-based coincidence reporter assay to measure PMP22 gene transcription in S16 Pmp22-F2sN cells - Primary screenPMP22PMP22targetBasedgeneticDisorderchromosomal disorder42576834
qHTS for Inhibitors of Polymerase EtaPOLHPOLHtargetBasedgeneticDisorderRare genetic skin disease3887174730
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complexPRKACBPRKACBtargetBasedgeneticDisordercardioacrofacial dysplasia 2343468273
qHTS Assay for Inhibitors of the CtBP/E1A InteractionRBBP8RBBP8targetBasedgeneticDisorderdevelopmental defect during embryogenesis3352141652
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM)SMARCA2SMARCA2targetBasedgeneticDisorderRare genetic developmental defect during embryogenesis3689273838
Luminescence cell-based high throughput primary assay to identify inhibitors of TEAD-YAP interaction.YAP1YAP1targetBasedgeneticDisorderRare genetic developmental defect during embryogenesis6394289218
MLPCN Platelet Activation -Dense Granule ReleaseplateletActivationInhibitorsphenotypichematologicthrombosis302451661
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]FGB_inhibitorsFGBtargetBasedhematologiccoagulation protein disease369953760
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]FGB_inhibitorsFGBtargetBasedhematologiccoagulation protein disease369953498
qHTS for Inhibitors of Cell Surface uPA GenerationPLAUPLAUtargetBasedhematologicinherited bleeding disorder, platelet-type3252471021
Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory ScreensRACGAP1RACGAP1targetBasedhematologicnormocytic anemia3420592057
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary ScreenIL-1b InflammasomeIL1BpathwayBasedimmuneInflammation CASP COPD36205117187
qHTS of Nrf2 ActivatorsNrf2 activatorsNFE2L2pathwayBasedimmuneCOPD4038711243
qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathwayRORCgammaPathwayInhibitorsRORCpathwayBasedimmuneautoimmuneDisorders7671874
qHTS for inhibitors of ROR gamma transcriptional activityRORCgammaPathwayInhibitorsRORCpathwayBasedimmuneautoimmuneDisorders30543916717
Primary cell-based high throughput screening assay to measure STAT1 activationSTAT1 activationSTAT1pathwayBasedimmuneimmunomodulation1959805134
Primary cell-based high throughput screening assay to measure STAT3 activationSTAT3STAT3pathwayBasedimmuneimmunomodulation1946661772
Primary cell-based high throughput screening assay to measure STAT3 inhibitionSTAT3STAT3pathwayBasedimmuneimmunomodulation1946661722
qHTS for Inhibitors of TGF-bTGFB1TGFB1pathwayBasedimmunefibrosis4033454970
IL-1B Induced NFkB Translocation - Primary Screen NFkB_Translocation_inhibitorsphenotypicimmuneimmunomodulation94265409
Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe TCR-CD3 interactionphenotypicimmuneautoimmuneDisorders3625741343
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathwayAntioxidant Response ElementphenotypicimmuneCOPD7671943
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound LibraryCTL granule exocytosisphenotypicimmuneimmunomodulation3638752400
Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_ActivityfibronectinDepositionphenotypicimmunefibrosis342865297
Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based System Using Plate Reader - 7124-01_Inhibitor_SinglePoint_HTS_ActivityInhibitors of CD40 SignalingphenotypicimmunerheumatoidArthritis82418778
Primary cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 bindinginhibitors of TLR4-MyD88 bindingphenotypicimmuneimmunomodulation195980357
Primary HTS assay for chemical potentiators of IL-1B stimulated NFkB nuclear translocationNFkB nuclear translocationphenotypicimmuneimmunomodulation94231282
uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activationNFKB1_activationphenotypicimmuneimmunomodulation3316701077
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activationNFKB1_activationphenotypicimmuneimmunomodulation3303921733
HTS to Find Inhibitors of Pathogenic Pemphigus AntibodiespemphigusAntibodiesInhibitorsphenotypicimmunepemphigus3113441495
HTS for Beta-2AR agonists via FAP methodADRB2_activatorsADRB2targetBasedimmuneasthma3392971446
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR)AHR_activatorsAHRtargetBasedimmuneimmunomodulation3247477988
Primary qHTS assay for inhibitors of Activation Induced Cytidine Deaminase (AID): AID signalAICDA_inhibitorsAICDAtargetBasedimmuneimmunomodulation90878289
qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase)ALOX15_inhibitorsALOX15targetBasedimmuneimmunomodulation731741034
Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphataseALPG_activatorsALPGtargetBasedimmuneimmunomodulation957291178
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTSALR activatorsGFERtargetBasedimmunefibrosis28872810857
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A)ANO1_inhibitorsANO1targetBasedimmunepsoriasis3065023633
human cGAS chemiluminescence screencGAS_inhibitorsCGAStargetBasedimmuneautoimmuneDisorders281243218
mouse cGAS chemiluminescence screencGAS_inhibitorsCGAStargetBasedimmuneautoimmuneDisorders160326237
mouse cGAS RapidFire screencGAS_inhibitorsCGAStargetBasedimmuneautoimmuneDisorders123258226
MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_SinglePoint_HTS_ActivityERAP1_inhibitorsERAP1targetBasedimmuneautoimmuneDisorders335777499
Primary HTS assay for chemical inhibitors of TNF alpha stimulated E-Selectin expressionE-selectinExpressionSELEtargetBasedimmuneimmunomodulation118096843
Toxoplasma gondii inhibition HTS in the presence of IFN-yIFNGIFNGtargetBasedimmuneImmune dysregulation disease with immunodeficiency672752509
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay.ITGB2ITGB2targetBasedimmuneimmune deficiency disease92518501
Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA)MSRAMSRAtargetBasedimmunefibrosis3620261074
uHTS luminescence assay for the identification of compounds that inhibit NOD2NOD2NOD2targetBasedimmuneCrohn's disease2923231836
uHTS of small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)p47phoxInhibitorsNCF1targetBasedimmunefibrosis2174541142
Fluorescence polarization assay for PLK1 inhibitorsPLK1PLK1targetBasedimmunetype II hypersensitivity reaction disease97099518
qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary ScreenPLK1PLK1targetBasedimmunetype II hypersensitivity reaction disease36406510181
qHTS Assay for Antagonists of the Relaxin Receptor RXFP1Taking the negative queue for PMsrelaxin PMsRXFP1targetBasedimmunefibrosis3501772058
qHTS Assay for Agonists of the Relaxin Receptor RXFP1RXFP1RXFP1targetBasedimmunefibrosis3621981084
Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism PotentiatorsS1PR1S1PR1targetBasedimmuneautoimmune disorder of the nervous system55710315
Primary HTS Assay for S1P3 AntagonistsS1PR3S1PR3targetBasedimmunetype II hypersensitivity reaction disease169141462
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE)SIAESIAEtargetBasedimmuneautoimmune disease3699332555
HTS of Smad transcription factor inhibitorsSMAD3SMAD3targetBasedimmunefibrosis88033251
Primary cell-based high throughput screening assay to measure STAT1 inhibitionSTAT1STAT1targetBasedimmunePrimary immunodeficiency due to a defect in innate immunity195980695
USP17 deubiquitinase inhibition: Primary qHTSUSP17L5USP17L5targetBasedimmuneimmunodeficiency disease474803075
Primary HTS assay for chemical inhibitors of TNF alpha stimulated VCAM1 expressionVCAM1_expressionVCAM1targetBasedimmuneimmunomodulation94498457
qHTS screening for TAG (triacylglycerol) accumulators in algaefuelBiosynthesisphenotypicindustriallipidBiosynthesis43680367
qHTS assay to identify small molecule agonists of the RXR signaling pathway:RXRA_pathway_agonistsRXRpathwayBasedmetabolicEndocrineinsulinSensitization7671173
High Throughput Imaging Assay for Hepatic Lipid Droplet Formation LipidDropletFormationphenotypicmetabolicEndocrineobesity236434954
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis.b cell apoptosisphenotypicmetabolicEndocrineT1Diabetes3035002435
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell linebeta-cell replicationphenotypicmetabolicEndocrinetype I and type II diabetes330392956
Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_ActivityGlucose-dependent insulin secretionphenotypicmetabolicEndocrineT2diabetes3711082287
HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 CellsInsulinPromoterDownRegulationphenotypicmetabolicEndocrineinsulinSignaling192372925
HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 CellsInsulinPromoterDownRegulationphenotypicmetabolicEndocrineinsulinSignaling192980574
qHTS Assay for Lipid Storage Modulators in Drosophila S3 CellslipidStorageInhibitorsphenotypicmetabolicEndocrineobesity3208582061
uHTS identification of small molecule modulators of Rev-erb Alpha.Rev-erb AlphaphenotypicmetabolicEndocrineobesity, diabetes and hyperlipidemia3715402956
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assayTriglycerideAccumulationInhibitorsphenotypicmetabolicEndocrineobesity, diabetes and hyperlipidemia2267211501
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4).ABHD4_inhibitorsABHD4targetBasedmetabolicEndocrineobesity3699532005
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assayACP1_inhibitorsACP1targetBasedmetabolicEndocrineobesity associated insulin resistance and  the metabolic syndrome363840817
qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)ALDH1A1_inhibitorsALDH1A1targetBasedmetabolicEndocrineobesity21688116026
Luminescent assay for identification of activators of bovine intestinal alkaline phosphataseALPI_activatorsALPItargetBasedmetabolicEndocrinecholesterolLevels195570326
uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphataseALPI_activatorsALPItargetBasedmetabolicEndocrinecholesterolLevels330392537
uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphataseALPI_activatorsALPItargetBasedmetabolicEndocrinecholesterolLevels331670785
qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode)GLP1RGLP1RtargetBasedmetabolicEndocrineendocrine pancreas disorder4051306428
qHTS of GLP-1 Receptor AgonistsGLP1R agonistsGLP1RtargetBasedmetabolicEndocrineT2Diabetes37346223
qHTS of GLP-1 Receptor Inverse Agonists: (PAM Mode) (Taking the negative queue for PAMs)GLP1R PAMsGLP1RtargetBasedmetabolicEndocrineT2Diabetes4051306428
qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTSGNASGNAStargetBasedmetabolicEndocrinehereditary hypoparathyroidism334825423
Cell-based high throughput primary assay to identify activators of GPR151GPR151GPR151targetBasedmetabolicEndocrinebody fat percentage6427016746
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1)HCRTR1HCRTR1targetBasedmetabolicEndocrineEnergy balance, obesity3260245748
Identify inhibitors of HNF4 alpha protein binding to DNAHNF4_binding_to_DNA_enhancersNR2A1targetBasedmetabolicEndocrinecongenitalDiabetes3638391098
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE)IDEIDEtargetBasedmetabolicEndocrineendocrine pancreas disorder335239245
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE)IDEIDEtargetBasedmetabolicEndocrineendocrine pancreas disorder3247471316
Primary screen for compounds that activate Insulin promoter activity in TRM-6 cellsINSINStargetBasedmetabolicEndocrineendocrine pancreas disorder1286951039
Primary screen for compounds that inhibit Insulin promoter activity in TRM-6 cellsINSINStargetBasedmetabolicEndocrineendocrine pancreas disorder1279611153
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4RMC4RMC4RtargetBasedmetabolicEndocrineEnergy balance, obesity3561603470
TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4RMC4RMC4RtargetBasedmetabolicEndocrineobesity3561601703
HTS identification of compounds activating phosphomannose isomerase (PMI) via a fluorescence intensity assay using a near- saturating concentration of mannose 6-phosphatMPIMPItargetBasedmetabolicEndocrinedisorder of glycosylation194152656
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphateMPIMPItargetBasedmetabolicEndocrinedisorder of glycosylation1941521288
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.MPIMPItargetBasedmetabolicEndocrinedisorder of glycosylation194152814
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2)NR2F2NR2F2targetBasedmetabolicEndocrineinsulinSensitization3699532602
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_ActivityPAX8PAX8targetBasedmetabolicEndocrinethyroid disease3539504145
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5)PLIN5PLIN5targetBasedmetabolicEndocrineobesity, diabetes, and cardiovascular disease3638032851
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder99314335
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder196176782
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder99314390
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder196177811
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder196176670
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma)PPARGPPARGtargetBasedmetabolicEndocrineendocrine pancreas disorder196177519
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL)PREPLPREPLtargetBasedmetabolicEndocrineinborn disorder of amino acid transport3247472221
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2RAD52RAD52targetBasedmetabolicEndocrinesystolic blood pressure3520741608
qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screenRAPGEF3RAPGEF3targetBasedmetabolicEndocrinethyroid disease364614268
qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screenRAPGEF3RAPGEF3targetBasedmetabolicEndocrinethyroid disease364614517
Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2THRBTHRBtargetBasedmetabolicEndocrinethyroid disease276265806
qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Agonists.TRHRTRHRtargetBasedmetabolicEndocrinethyroid disease361330651
HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1TRPV1TRPV1targetBasedmetabolicEndocrineAbnormality of metabolism/homeostasis316642617
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaignTSHRTSHRtargetBasedmetabolicEndocrinethyroid disease329153670
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaignTSHRTSHRtargetBasedmetabolicEndocrinethyroid disease329153670
qHTS Assay for Agonists of the Thyroid Stimulating Hormone ReceptorTSHRTSHRtargetBasedmetabolicEndocrinethyroid disease72026352
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293TSHRTSHRtargetBasedmetabolicEndocrinethyroid disease720261794
Inhibitors of the vitamin D receptor (VDR): qHTSVDRVDRtargetBasedmetabolicEndocrinenutritional deficiency disease3940503624
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_ActivityC2C12_myopathyphenotypicmuculoEskeletalConnectivemyotoxicity3292742586
uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assayALPL_inhibitorsALPLtargetBasedmuculoEskeletalConnectiveboneDisease195560517
HTS for inhibitors of DUX4-mediated transcriptional activationDUX4_inhibitorsDUX4targetBasedmuculoEskeletalConnectivemuscularDystrophy36365289
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoterFXNFXNtargetBasedmuculoEskeletalConnectiveFriedreich ataxia3561601985
qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe DiseaseGAAGAAtargetBasedmuculoEskeletalConnectivefamilial cardiomyopathy199169715
qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of GlycogenGAA_inhibitorsGAAtargetBasedmuculoEskeletalConnectivefamilial cardiomyopathy3022971165
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assayGLI1GLI1targetBasedmuculoEskeletalConnectivenon-syndromic polydactyly3383282501
A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells.GMNNGMNNtargetBasedmuculoEskeletalConnectivebone disease3432349888
A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells.GMNNGMNNtargetBasedmuculoEskeletalConnectivebone disease3422796233
RNA aptamer-based HTS for inhibitors of GRK2GRK2GRK2targetBasedmuculoEskeletalConnectivebone disease3279391924
qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)HPGDHPGDtargetBasedmuculoEskeletalConnectivehypertrophic osteoarthropathy, primary, autosomal recessive, 11484806428
Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1KCNJ2KCNJ2targetBasedmuculoEskeletalConnectivefamilial periodic paralysis3056102592
Luminescent HTS for small molecule inhibitors of MT1-MMP transcriptionMMP14MMP14targetBasedmuculoEskeletalConnectivebone disease86733537
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assayMMP14MMP14targetBasedmuculoEskeletalConnectivebone disease361500222
uHTS Luminescent assay for identification of inhibitors of NALP3 in yeastNLRP3NLRP3targetBasedmuculoEskeletalConnectiveconnective tissue disease3303921295
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS)PADI4PADI4targetBasedmuculoEskeletalConnectiveconnective tissue disease3260221334
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2)PAFAH2PAFAH2targetBasedmuculoEskeletalConnectivebone fracture related measurement3352393325
qHTS for PTHR1 Agonists: Primary ScreenPTH1RPTH1RtargetBasedmuculoEskeletalConnectivebone development disease405685308
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2Schnurri-3 InhibitorsHIVEP3targetBasedmuculoEskeletalConnectiveosteoporosis3568831841
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding.TLR9TLR9targetBasedmuculoEskeletalConnectiveconnective tissue disease343468734
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)TNNI3TNNI3targetBasedmuculoEskeletalConnectivehypertrophic cardiomyopathy335239801
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)TNNI3TNNI3targetBasedmuculoEskeletalConnectivehypertrophic cardiomyopathy335238390
Primary screen for compounds that activate Alzheimer's amyloid precursorAPP_inhibitorsAPPpathwayBasednervousSystemneurodegeneration1934001987
Primary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translationAPP_inhibitorsAPPpathwayBasednervousSystemAD1937141590
Primary cell-based high-throughput screening assay to identify transcriptional activators of heat shock protein 70 (Hsp70)Heat shock 70kDa protein 1AHSP70pathwayBasednervousSystemneurodegeneration19617682
Luminescence-based cell-based primary high throughput screening assay to identify activators of Transthyretin (TTR) transcriptionHEL111HEL111pathwayBasednervousSystemneurodegeneration919091155
qHTS for Inhibitors of Tau Fibril Formation, Fluorescence PolarizationMAPTMAPTpathwayBasednervousSysteminherited neurodegenerative disorder2714021048
qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T BindingMAPTMAPTpathwayBasednervousSystemneurodegeneration2674125703
High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary ScreenNFKB1NFKB1pathwayBasednervousSystemneurodegeneration1932653100
Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA)RORARORApathwayBasednervousSystemintellectual developmental disorder with or without epilepsy or cerebellar ataxia64908979
Primary Cell-based High Throughput Screening assay for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA)RORARORApathwayBasednervousSystemintellectual developmental disorder with or without epilepsy or cerebellar ataxia64908278
Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expressionSNCASNCApathwayBasednervousSysteminherited neurodegenerative disorder140118236
qHTS of alpha-syn InhibitorsSNCASNCApathwayBasednervousSysteminherited neurodegenerative disorder368791501
qHTS of TDP-43 InhibitorsTARDBPTARDBPpathwayBasednervousSystemneurodegeneration4037037150
qHTS of TDP-43 Inhibitors: NCGC Sytravon Library ScreenTARDBPTARDBPpathwayBasednervousSysteminherited neurodegenerative disorder45163203
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitorsaSynucleinExpressionInhibitorsphenotypicnervousSystemPD3038012498
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeatscagRnaRepeatsphenotypicnervousSystemhuntington3689274667
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assaymPTPphenotypicnervousSystemneurodegeneration3638405033
Cell signaling CRE-BLA (Fsk stim)_modulatorsCREBtargetBasednervousSystemlongTermMemory696691744
Modulation of AMPAR-stargazin complexesAMPAStargazinComplexModulatorsCACNG2targetBasednervousSystemepilepsy404731400
uHTS Fluorescent assay for identification of inhibitors of Apaf-1APAF1_inhibitorsAPAF1targetBasednervousSystemneurodegeneration3316712353
qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary ScreenAPP_inhibitorsAPPtargetBasednervousSystemneurodegeneration404343257
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1)ARFGAP1_inhibitorsARFGAP1targetBasednervousSystemAD362539954
qHTS Assay for Identifying a Potential Treatment of Ataxia-TelangiectasiaATM_modulatorsATMtargetBasednervousSystemataxiaTelangiectasia322361619
Primary qHTS for Inhibitors of ATXN expressionATXN2_repressorsATXN2targetBasednervousSystemspinocerebellarAtaxia3584342554
Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R)AVPR1A_agonistsAVPR1AtargetBasednervousSystembehavioralDisorders324747813
qHTS Assay for Inhibitors of BAZ2BBAZ2B_modulatorsBAZ2BtargetBasednervousSystemneurodevelopmentalDisorders35682615709
Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) AssayCACNA1B_modulatorsCACNA1BtargetBasednervousSystempain292323567
Inhibitors of Cav3 T-type Calcium Channels: Primary ScreenCACNA1H_inhibitorsCACNA1HtargetBasednervousSystemepilepsy1047284230
uHTS for Calpain InhibitorscalpainInhibitorsCAPN2targetBasednervousSystemneurodegeneration218602799
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2Caspase6InhibitorsCASP6targetBasednervousSystemneurodegeneration3443181854
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1)CHRM1_agonistsCHRM1targetBasednervousSystemneurodegeneration3592071189
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary ScreenCHRM1_allosteric_activatorsCHRM1targetBasednervousSystemneurodegeneration636761938
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1).CHRM1_PAMsCHRM1targetBasednervousSystemneurodegeneration359207316
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4_agonistsCHRM4targetBasednervousSystempsychosis363803502
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4_antgonistsCHRM4targetBasednervousSystemPD3638032629
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4)CHRM4_PAMsCHRM4targetBasednervousSystemAD3638031450
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complexCRHBP_antagonistsCRHBPtargetBasednervousSystemdrugAddiction3489232056
Allosteric Modulators of D1 Receptors: Primary ScreenD1DRD1targetBasednervousSystemPD577053413
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTSD1_activatorsDRD1targetBasednervousSystemPD3613303713
Antagonist of Human D 1 Dopamine Receptor: qHTSD1_inhibitorsDRD1targetBasednervousSystempsychosis35580511440
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: AgonistsD2_agonistsDRD2targetBasednervousSystemPD359518300
HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for AgonistsD2_agonistsDRD2targetBasednervousSystemPD3356521779
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: AntagonistsD2_antagonistsDRD2targetBasednervousSystempsychosis3622741056
HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for AntagonistsD2_antagonistsDRD2targetBasednervousSystempsychosis3363086862
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: PotentiatorsD2_PAMsDRD2targetBasednervousSystemPD357537806
HTS Assay for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Primary Screen for PotentiatorsD2_PAMsDRD2targetBasednervousSystemPD3398871178
qHTS of D3 Dopamine Receptor Agonist: qHTSD3_agonistsDRD3targetBasednervousSystemneurodegeneration4075392380
qHTS of D3 Dopamine Receptor Antagonist: qHTSD3_antagonistsDRD3targetBasednervousSystemdrugAddiction3640519106
qHTS of D3 Dopamine Receptor Potentiators: qHTSD3_PAMsDRD3targetBasednervousSystemneurodegeneration4075392380
Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_ActivityDYRK1A_inhibitorsDYRK1AtargetBasednervousSystemgeneticNeurodevelopmentalDisability3100141321
qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1).FEN1_inhibitorsFEN1targetBasednervousSystemneurodegeneration3862701331
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_ActivityFOSBFOSBtargetBasednervousSystemneurodegeneration3373913330
qHTS for Suppressors of FUS Proteinopathy: Primary screen using FUS-linked yeast assayFUS_asupressorsFUStargetBasednervousSystemsporadic amyotrophic lateral sclerosis385746932
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore)GNAI1GNAI1targetBasednervousSystemNeurodevelopmental disorder2298881007
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao.GNAO1GNAO1targetBasednervousSystemMendelian neurodevelopmental disorder218528711
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.GNAO1GNAO1targetBasednervousSystemMendelian neurodevelopmental disorder218528770
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.GNAO1GNAO1targetBasednervousSystemMendelian neurodevelopmental disorder218528750
Primary qHTS assay for inhibitors of Glutamate pyruvate transaminase 2 (GPT2)GPT2GPT2targetBasednervousSysteminherited neurodegenerative disorder98912236
uHTS identification of small molecule modulators of NR3AGRIN3AGRIN3AtargetBasednervousSystemneurodegeneration3397728480
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1).GSTO1GSTO1targetBasednervousSystemneurodegeneration3026633200
HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone TailsHP1-betaChromodomainInteractionsInhibitorsCBX1targetBasednervousSystemneurodegeneration3833632142
Alphascreen assay for small molecules abrogating mHTT-CaM InteractionHTTHTTtargetBasednervousSystemHuntington disease1898826790
Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter ActivityHTTHTTtargetBasednervousSystemHuntington disease48068449
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP)HTTHTTtargetBasednervousSystemHuntington disease2205712380
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP)HTTHTTtargetBasednervousSystemHuntington disease223611305
Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (IP6K1)IP6K1IP6K1targetBasednervousSystemneurodegeneration1432291157
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channelsKCNQ2KCNQ2targetBasednervousSystemRare genetic epilepsy3056093405
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channelsKCNQ2KCNQ2targetBasednervousSystemRare genetic epilepsy3056001644
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 WildtypeMAP4K2MAP4K2targetBasednervousSystemneurodegeneration2894653276
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutantMAP4K2MAP4K2targetBasednervousSystemneurodegeneration2895391003
qHTS Assay for Tau Filament BindingMAPTMAPTtargetBasednervousSysteminherited neurodegenerative disorder696681391
High-Throughput Screening for Modulators of Cytosolic Chaperonin ActivityMARVELD2MARVELD2targetBasednervousSystemhearing disorder3622741085
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide.MCL1MCL1targetBasednervousSystemneurodegeneration3149982139
uHTS of Mcl-1/Bid interaction inhibitorsMCL1MCL1targetBasednervousSystemneurodegeneration2186022129
uHTS of Mcl-1/Noxa interaction inhibitorsMCL1MCL1targetBasednervousSystemneurodegeneration2173303334
Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel ML3 (TRPML3)MCOLN3MCOLN3targetBasednervousSystemneurodegeneration217959632
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1NR0B1NR0B1targetBasednervousSystempalsy3689274094
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1)NR0B1NR0B1targetBasednervousSystempalsy3434683417
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)NR2E3NR2E3targetBasednervousSystemneurodegeneration3620261281
TR-FRET-based primary biochemical high throughput screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3).NR2E3NR2E3targetBasednervousSystemneurodegeneration314998380
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2)PAFAH1B2PAFAH1B2targetBasednervousSystemneurodegeneration3352394158
qHTS for small molecular inhibitors of PI4K2API4K2API4K2AtargetBasednervousSystemneurodegeneration414643532
qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)PIP4K2APIP4K2AtargetBasednervousSystemneurodegeneration3288604078
qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate KinasePKMPKMtargetBasednervousSystemneurodegeneration263662892
qHTS Assay for Inhibitors of DNA Polymerase BetaPOLBPOLBtargetBasednervousSystemneurodegeneration3344574509
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1).PPME1PPME1targetBasednervousSystemneurodegeneration3149991683
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1).PPP1CAPPP1CAtargetBasednervousSystemneurodegeneration3149992841
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1)PRMT1PRMT1targetBasednervousSystemneurodegeneration3699534757
Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK)PTK2PTK2targetBasednervousSystemneurodegeneration96879811
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assayPTPN5PTPN5targetBasednervousSystemneurodegeneration359244887
S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_ActivityS100A4S100A4targetBasednervousSystemneurodegeneration352235501
Primary Cell-Based High-Throughput Screening to Identify Agonists of the Sphingosine 1-phosphate receptor 2 (S1P2)S1PR2S1PR2targetBasednervousSystemhearing disorder96879447
Primary Cell-Based High-Throughput Screening to Identify Antagonists of the Sphingosine 1-phosphate receptor 2 (S1P2)S1PR2S1PR2targetBasednervousSystemhearing disorder96879207
uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assaySENP1SENP1targetBasednervousSystemneurodegeneration363840774
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6)SENP6SENP6targetBasednervousSystemneurodegeneration3303925817
qHTS Assay for Inhibitors of the Six1/Eya2 InteractionSIX1SIX1targetBasednervousSysteminherited auditory system disease3640532026
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary ScreenSLC12A5SLC12A5targetBasednervousSystemmonogenic epilepsy1891324127
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT)SLC5A7SLC5A7targetBasednervousSystemneurodegeneration3065022634
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1)TAAR1TAAR1targetBasednervousSystemPD3625775374
qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1)TDP1TDP1targetBasednervousSysteminherited neurodegenerative disorder344442978
qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPTTDP1TDP1targetBasednervousSysteminherited neurodegenerative disorder41682463248
qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPTTDP1TDP1targetBasednervousSysteminherited neurodegenerative disorder41685649238
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)TDP2TDP2targetBasednervousSysteminherited neurodegenerative disorder3699531241
A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37UCHL5UCHL5targetBasednervousSystemneurodegeneration3307071075
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotideUHRF1UHRF1targetBasednervousSystemneurodegeneration3699532779
Inhibitors of USP1/UAF1: Primary ScreenUSP1USP1targetBasednervousSystemneurodegeneration389569904
USP28 deubiquitinase inhibition: Primary qHTSUSP28USP28targetBasednervousSystemneurodegeneration474801413
USP30 deubiquitinase inhibition: Primary qHTSUSP30USP30targetBasednervousSystemneurodegeneration474802500
Primary biochemical high-throughput screening assay to measure P97 ATPase inhibitionVCPVCPtargetBasednervousSystemneurodegeneration217959923
Primary Cell-based High Throughput Screening Assay for Inhibitors of Wee1 DegradationWEE1WEE1targetBasednervousSystemneurodegeneration2179592616
HTS for 14-3-3 protein interaction modulatorsYWHAGYWHAGtargetBasednervousSystemmonogenic epilepsy157962312
CYP2C19 AssayCYP2C19_inhibitorsCYP2C19targetBasednotSpecifiednotSpecified9585720295
CYP2C9 AssayCYP2C9_inhibitorsCYP2C9targetBasednotSpecifiednotSpecified9585818730
Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 ActivityKDM4CKDM4CtargetBasedotherPhenotypesage at menarche326066228
Fluorescence-based primary cell-based high throughput screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7).NPBWR1NPBWR1targetBasedotherPhenotypesage at menarche2907263127
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao.RGS16RGS16targetBasedotherPhenotypescircadian rhythm218528826
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC)PRNPPRNPtargetBasedprionDiseaseprionDisease3699531596
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_ActivityWnt/Beta-catenin pathwayphenotypicpsychiatricDisorderschizophrenia3042183630
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3)GALR3_antagonistsGALR3targetBasedpsychiatricDisorderanxiety3578591562
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary ScreeningGRM8GRM8targetBasedpsychiatricDisordermental or behavioural disorder1051512166
Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alphaGSK3AGSK3AtargetBasedpsychiatricDisordermental or behavioural disorder315412318
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1)HCRTR1HCRTR1targetBasedpsychiatricDisorderinsomnia3260241387
Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonistsHTR1AHTR1AtargetBasedpsychiatricDisordermajor depressive disorder64908366
Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonistsHTR1AHTR1AtargetBasedpsychiatricDisordermajor depressive disorder61606416
Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E)HTR1EHTR1EtargetBasedpsychiatricDisordercognitive disorder64908446
Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E)HTR1EHTR1EtargetBasedpsychiatricDisordercognitive disorder64908641
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A)HTR2AHTR2AtargetBasedpsychiatricDisorderdevelopmental disorder of mental health3638032412
Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A)HTR5AHTR5AtargetBasedpsychiatricDisorderschizophrenia3352392035
Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A)HTR5AHTR5AtargetBasedpsychiatricDisorderschizophrenia335239279
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1)HTRA1HTRA1targetBasedpsychiatricDisordercerebral arteriopathy with subcortical infarcts and leukoencephalopathy3434671710
qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with LithiumIMPA1IMPA1targetBasedpsychiatricDisordermental or behavioural disorder205582727
qHTS for Inhibitors of KCHN2 3.1: Mutant qHTSKCNH2KCNH2targetBasedpsychiatricDisorderschizophrenia3420843260
Primary screen for KDM5B Histone Demethylases FDH-coupled qHTSKDM5BKDM5BtargetBasedpsychiatricDisordermental or behavioural disorder2178195697
qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal TransductionNPSR1NPSR1targetBasedpsychiatricDisorderanxiety2208622309
Primary cell-based high-throughput screening assay for antagonists of NPY-Y1NPY1RNPY1RtargetBasedpsychiatricDisorderanxiety1961761984
Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1NPY1RNPY1RtargetBasedpsychiatricDisordermental process217959798
Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR).OXTROXTRtargetBasedpsychiatricDisordermental or behavioural disorder3247471043
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3)PAFAH1B3PAFAH1B3targetBasedpsychiatricDisorderpervasive developmental disorder335239928
qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screenRAPGEF4RAPGEF4targetBasedpsychiatricDisordermental process364614290
qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screenRAPGEF4RAPGEF4targetBasedpsychiatricDisordermental process364614663
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4)RGS4RGS4targetBasedpsychiatricDisordercognitive disorder3056101365
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4)RGS4RGS4targetBasedpsychiatricDisordercognitive disorder3056102820
High Throughput Screening for Cocaine Antagonists: Primary ScreenSLC6A3SLC6A3targetBasedpsychiatricDisorderdrug addiction1082861415
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1)TAAR1TAAR1targetBasedpsychiatricDisorderschizophrenia3625773573
qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for EnhancersTRHRTRHRtargetBasedpsychiatricDisorderanxiety3613302424
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assayNFKB1NFKB1pathwayBasedrareDiseasescysticFibrosis3592443094
qHTS Assay for NPC1 Promoter ActivatorsNPC1NPC1pathwayBasedrareDiseasesNiemann Pick Type C (NPC)3206827575
qHTS Assay for Rab9 Promoter ActivatorsRAB9ARAB9ApathwayBasedrareDiseasesNiemann Pick Type C (NPC)3206039133
qHTS Assay for Enhancers of SMN2 Splice Variant ExpressionSMN1; SMN2SMN1; SMN2pathwayBasedrareDiseasesSMA2084895817
Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_SinglePoint_HTS_ActivitycftrCorrectorsCFTRtargetBasedrareDiseasescysticFibrosis3437861253
Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_ActivitycftrTrafficModulatorsCFTRtargetBasedrareDiseasescysticFibrosis2965012737
qHTS for Activators of Integrin-Mediated Alleviation for Muscular DystrophyCGA_integrin_activatorsCGAtargetBasedrareDiseasesmuscularDistrophy345855222
qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTSGNASGNAStargetBasedrareDiseasesMcCune-Albright syndrome (MAS)3374461356
HTS of Estrogen Receptor- alpha Coactivator Binding PotentiatorsESR1_modulatorsESR1targetBasedreproductiveSystemmenopauseSymptoms860951151
uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1PHOSPHO1PHOSPHO1targetBasedreproductiveSystemsex hormone-binding globulin measurement2883213164
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary ScreenPTGER2PTGER2targetBasedreproductiveSystemmale reproductive system disease2501901304
Modulators of the EP2 prostaglandin E2 receptor - Primary ScreeningPTGER2PTGER2targetBasedreproductiveSystemmale reproductive system disease2555372141
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2)RIPK2RIPK2targetBasedreproductiveSystemmale reproductive system disease3638031383
Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A)ANO1_activatorsANO1targetBasedrespiratorypulmonary arterial hypertension3351801022
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary ScreenCHRM1_allosteric_antagonistsCHRM1targetBasedrespiratoryrespiratoryDisorders636562179
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1)CHRM1_antgonistsCHRM1targetBasedrespiratoryrespiratoryDisorders3592074555
SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_ActivityID4ID4targetBasedrespiratorypulmonary function measurement31324362
Small-molecule inhibitors of ST2 (IL1RL1)IL1RL1IL1RL1targetBasedrespiratorybronchial disease759241804
qHTS for Inhibitors of Polymerase IotaPOLIPOLItargetBasedrespiratorylower respiratory tract disease3860633989
uHTS HTRF assay for identification of inhibitors of SUMOylationUBE2IUBE2ItargetBasedrespiratoryrespiratory system disease2909151039
High throughput discovery of novel modulators of ROMK K+ channel activity: Primary ScreenKCNJ1KCNJ1targetBasedurinarySystemrenal tubular transport disease1252682463
High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6)TRPC6TRPC6targetBasedurinarySystemfocal segmental glomerulosclerosis305610382
High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6)TRPC6TRPC6targetBasedurinarySystemfocal segmental glomerulosclerosis3056103253
qHTS Assay for Identification of Novel General AnestheticsFTLFTLtargetBasedvisualSystemeye disease341499255
GlucocerebrosidaseGBA1GBA1targetBasedvisualSystemeye disease48118549
Colorimetric Assay for Inhibitors for NALP1NLRP1NLRP1targetBasedvisualSystemeye disease2800241717
Primary biochemical high-throughput screening assay for inhibitors of Rho kinase 2 (Rhok2)ROCK2ROCK2targetBasedvisualSystemeye disease59788212
Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT)SLC5A7SLC5A7targetBasedvisualSystemeye disease3065021509
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN.MEP2MEP2pathwayBased3266511682
A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 ExpressionPARK2PARK2pathwayBased406283823
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN.RPL19BRPL19BpathwayBased325372982
qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher DiseaseGBAGBAtargetBased321552295
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction.GLD-1GLD-1targetBased3247461419
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assayGPR183GPR183targetBased3638402946
qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTSHEL-S-26HEL-S-26targetBased387604365
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1)HKDC1HKDC1targetBased340696540
uHTS identification of small molecule activators of alpha dystroglycan glycosylationLARGELARGEtargetBased363840805
MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary ScreenMEX-5MEX-5targetBased3017881137
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signalingMGRG2MGRG2targetBased3065021351
Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signalingMGRG2MGRG2targetBased3065021932
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signalingMGRG2MGRG2targetBased3065023868
Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA)MSRAMSRAtargetBased3625772709
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)NCOA3NCOA3targetBased359207620
uHTS luminescence assay for the identification of compounds that inhibit NOD1NOD1NOD1targetBased2894222997
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assayNRP1NRP1targetBased3638403086
Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo AssayNTMT1NTMT1targetBased564401336
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5).PPP5CPPP5CtargetBased314999564
High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar CompartmentPTBP1PTBP1targetBased1397184338
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia TargetPTPN7PTPN7targetBased112381724
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtypeRAB2ARAB2AtargetBased194628365
Primary biochemical high throughput screening assay to identify inhibitors of Retinoblastoma binding protein 9 (RBBP9)RBBP9RBBP9targetBased217959445
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assayRPN11RPN11targetBased3592442134
Primary Cell-Based Assay to Identify Agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4)S1PR4S1PR4targetBased217959771
Primary Cell-Based Assay to Identify Antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4)S1PR4S1PR4targetBased217959569
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_ActivitySCARB1SCARB1targetBased316970306
Identification and characterization of compounds for addressing human bone marrow failureSDO1SDO1targetBased138737298
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7)SENP7SENP7targetBased3316704902
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5SIRT5SIRT5targetBased3235073752
uHTS identification of SKN-1 Inhibitors in a fluoresence assaySKN-1SKN-1targetBased3638401794
qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociationSNUPNSNUPNtargetBased340719242
Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33STK33STK33targetBased373412812
Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 ActivitySTK33STK33targetBased321808235
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assayTIM10TIM10targetBased3316714615
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assayTIM10TIM10targetBased3316717319
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assayTIM23TIM23targetBased3316714405
uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cellsTNFSF10TNFSF10targetBased217035883
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4)TRPC4TRPC4targetBased3056001291
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4).TRPC4TRPC4targetBased3056001510
Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4).TRPC4TRPC4targetBased3040011189
Primary cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1)TRPN1TRPN1targetBased217959390
uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET AssayUBE2NUBE2NtargetBased3303931538
USP10 deubiquitinase inhibition: Primary qHTSUSP10USP10targetBased47480509
uHTS for 14-3-3/Bad interaction inhibitorsYWHAZYWHAZtargetBased2173321549

Note: disease association is the one established by assay depositors in PubChem. When this is not explicit, this parameter is filled with the best scored target-disease associations recorded in openTargets DB. 

 

OpenTargets DB provides comprehensive insights into the relationships between genes, diseases, and drugs by combining data from various sources, including genomics, transcriptomics, and clinical research. Each gene from Phchem target-based screens will have multiple scored associations to multiple diseases based on qualitative and quantitative information from mentioned data sources so that indications recorded in Pchem can be expanded to a wide range of indications in multiple therapeutic areas.

 

Check it in the drTarget expanded indications portfolio. 
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Targets association to different therapeutic areas as defined in OpenTargetsDB.

 

Graph view of the interconnection of target and diseases associations through different disease types.