pathway pathwayID scoreForPathway scoreForSMN2 countOfMolecules TotalEvents CountOfTargets Abacavir transmembrane transport R-HSA-2161517 5.48656132998833 5.22151170647221 215 340 2 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway R-HSA-73930 5.84832553209277 5.3102296054936 5501 5659 1 ABC-family proteins mediated transport R-HSA-382556 5.47197083318364 5.33707544861092 336 972 10 Acetylcholine Neurotransmitter Release Cycle R-HSA-264642 5.62250136257333 5.36927224099099 123 160 2 Acrosome Reaction R-HSA-1300645 5.20791045929864 5.29194951415989 12 16 1 Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 5.52213439976952 5.44369181250209 147 186 4 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 5.25580084014247 5.2489098411921 573 1061 3 Activated point mutants of FGFR2 R-HSA-2033519 5.81536206283133 5.14400425840911 240 341 4 activated TAK1 mediates p38 MAPK activation R-HSA-450302 5.53800271032422 5.23630784562954 313 703 6 Activation of AMPA receptors R-HSA-399710 5.45946693277095 5.34322667925601 95 217 4 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5617472 6.25816883968958 5.29032101496515 354 3286 6 Activation of ATR in response to replication stress R-HSA-176187 5.84623362242792 5.20230381415836 1535 2971 6 Activation of BAD and translocation to mitochondria R-HSA-111447 6.33126633859999 5.04050264550264 63 75 1 Activation of Ca-permeable Kainate Receptor R-HSA-451308 5.88143385270058 5.44084983031674 69 120 2 Activation of caspases through apoptosome-mediated cleavage R-HSA-111459 5.22941716497047 5.27345748947792 880 951 3 Activation of DNA fragmentation factor R-HSA-211227 5.0390976048247 5.22505673987361 426 488 1 Activation of E2F1 target genes at G1/S R-HSA-539107 5.60809710341188 5.24172390964249 1434 6222 5 Activation of G protein gated Potassium channels R-HSA-1296041 5.4741940857008 5.31862125054201 6 24 3 Activation of gene expression by SREBF (SREBP) R-HSA-2426168 5.99354923801571 5.24774900303798 482 663 9 Activation of Matrix Metalloproteinases R-HSA-1592389 5.93213509543456 5.40562434522386 1881 2816 14 Activation of Na-permeable kainate receptors R-HSA-451307 5.72676090451021 5.35790064102564 52 79 1 Activation of NF-kappaB in B cells R-HSA-1169091 5.38811733101095 5.34310755980783 2742 11006 11 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 5.34951614328384 5.18775102782625 815 2649 3 Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2151209 5.42596513949323 5.17524731061442 392 3098 6 Activation of Rac R-HSA-428540 5.07989592400502 5.28270942278107 89 142 2 Activation of RAS in B cells R-HSA-1169092 6.02973169408175 6.48485714285714 19 25 5 Activation of SMO R-HSA-5635838 5.67907705384005 5.425 38 52 4 Activation of the AP-1 family of transcription factors R-HSA-450341 5.08650762737216 5.28710308641975 139 415 2 Activation of the phototransduction cascade R-HSA-2485179 5.57228664708695 5.41693928571429 170 920 6 Activation of the pre-replicative complex R-HSA-68962 5.88409960141061 5.18122724747917 1038 2353 4 Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108 6.61400597529229 5.24333182147503 37 38 2 Acyl chain remodeling of CL R-HSA-1482798 5.58673609874305 5.19641059027778 27 34 2 Acyl chain remodeling of DAG and TAG R-HSA-1482883 6.7029765603862 5.28682745691524 58 68 1 Acyl chain remodelling of PC R-HSA-1482788 5.46551215286232 5.32218293981481 62 79 5 Acyl chain remodelling of PE R-HSA-1482839 5.46551215286232 5.32218293981481 62 79 5 Acyl chain remodelling of PG R-HSA-1482925 5.52056072686214 5.35814534143519 59 76 4 Acyl chain remodelling of PI R-HSA-1482922 5.52056072686214 5.35814534143519 59 76 4 Acyl chain remodelling of PS R-HSA-1482801 5.52056072686214 5.35814534143519 59 76 4 Adenosine P1 receptors R-HSA-417973 5.36824991353461 5.25044289061229 2342 3212 4 ADP signalling through P2Y purinoceptor 1 R-HSA-418592 5.53460379426426 5.28509244030214 62 81 3 ADP signalling through P2Y purinoceptor 12 R-HSA-392170 6.75679019969576 5.16625 91 120 1 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 6.55099569305388 5.27308312239205 39 118 3 Adrenoceptors R-HSA-390696 5.94705224350675 5.26196912930865 549 1065 3 Advanced glycosylation endproduct receptor signaling R-HSA-879415 5.85569005124943 5.23214082773191 224 304 2 Aflatoxin activation and detoxification R-HSA-5423646 6.2475 5.205078125 2 4 1 AKT phosphorylates targets in the cytosol R-HSA-198323 5.51368143453445 5.21560781676872 1190 1612 5 Alpha-defensins R-HSA-1462054 5.50446756301205 5.40949074919638 234 710 2 alpha-linolenic acid (ALA) metabolism R-HSA-2046106 5.78039206469598 5.24717013888889 12 12 1 Alternative complement activation R-HSA-173736 7.08576086956522 5.24982608695652 92 92 1 Amine ligand-binding receptors R-HSA-375280 5.3592104836757 5.29196632420091 73 136 1 Amino acid synthesis and interconversion (transamination) R-HSA-70614 6.29487773844013 5.5107626261443 63 89 3 Amino acid transport across the plasma membrane R-HSA-352230 5.03531699173092 5.74433035714286 14 16 1 AMPK inhibits chREBP transcriptional activation activity R-HSA-163680 5.59158407297442 5.18422772435897 248 2188 5 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141444 5.47739919282561 5.26705224346428 402 501 1 Amyloid fiber formation R-HSA-977225 5.48176508248161 5.32449699867131 732 1046 4 Anchoring fibril formation R-HSA-2214320 6.88912186343669 5.04375 18 19 1 Anchoring of the basal body to the plasma membrane R-HSA-5620912 5.12214709201599 5.22264678372518 1086 7645 7 Androgen biosynthesis R-HSA-193048 5.68404003895041 5.22613648910799 3776 3786 5 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695 5.56282105593051 5.15919093073597 662 1005 5 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 5.60580979692161 5.50141701694562 153 292 5 Antimicrobial peptides R-HSA-6803157 5.39736797315064 5.31722716613092 259 744 3 APC truncation mutants have impaired AXIN binding R-HSA-5467337 5.46016753441551 5.2417614682648 698 930 1 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 5.25265285246997 5.20845734258035 706 2029 2 APC/C:Cdc20 mediated degradation of Securin R-HSA-174154 5.57566597051573 5.66322599261311 45 138 2 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 5.49394554526246 5.4652429615346 988 1251 4 APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689 6.83044981096182 5.0226179245283 53 66 1 Apoptotic cleavage of cell adhesion proteins R-HSA-351906 5.0390976048247 5.22505673987361 426 488 1 Apoptotic cleavage of cellular proteins R-HSA-111465 5.52757398772828 5.29127926492605 1396 2537 8 Apoptotic execution phase R-HSA-75153 5.48014013948107 5.23277225950922 74 110 2 Arachidonate production from DAG R-HSA-426048 5.62 5.90729166666667 6 6 1 Arachidonic acid metabolism R-HSA-2142753 5.77521433634385 5.22160364395302 97 110 2 ARL13B-mediated ciliary trafficking of INPP5E R-HSA-5624958 5.59960161473802 5.42032327586207 29 154 1 ARMS-mediated activation R-HSA-170984 5.98270193946343 5.24154246954105 157 280 3 Aryl hydrocarbon receptor signalling R-HSA-8937144 5.13199589765744 5.23506984429221 278 514 2 Assembly of active LPL and LIPC lipase complexes R-HSA-8963889 6.93 5.439865625 80 82 1 Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 5.69022786039325 5.31031990314279 1275 1582 8 Assembly Of The HIV Virion R-HSA-175474 6.83044981096182 5.0226179245283 53 66 1 Association of licensing factors with the pre-replicative complex R-HSA-69298 5.20458966266821 5.3080664759398 12574 15814 1 Association of TriC/CCT with target proteins during biosynthesis R-HSA-390471 5.81048134564275 5.2814566124929 564 4417 3 Asymmetric localization of PCP proteins R-HSA-4608870 5.57566597051573 5.66322599261311 45 138 2 ATF4 activates genes R-HSA-380994 6.38367208996524 5.45331597222222 7 10 3 ATF6 (ATF6-alpha) activates chaperone genes R-HSA-381183 5.04167369137651 5.353984375 12 13 2 ATP sensitive Potassium channels R-HSA-1296025 5.94293393876614 5.2647849516369 114 688 4 Attachment of GPI anchor to uPAR R-HSA-162791 5.32285714285714 5.57053571428572 7 7 1 Attenuation phase R-HSA-3371568 5.29948670773948 5.32845775661944 472 888 2 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408 5.57566597051573 5.66322599261311 45 138 2 AURKA Activation by TPX2 R-HSA-8854518 5.15026008641309 5.22824938794052 1627 8257 8 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084 5.57566597051573 5.66322599261311 45 138 2 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425 5.57566597051573 5.66322599261311 45 138 2 AXIN missense mutants destabilize the destruction complex R-HSA-5467340 5.46016753441551 5.2417614682648 698 930 1 Axonal growth inhibition (RHOA activation) R-HSA-193634 5.43913063570619 5.11826388888889 3 3 1 Axonal growth stimulation R-HSA-209563 5.71956531785309 5.17371527777778 4 4 2 Basigin interactions R-HSA-210991 6.35169123016111 5.48751546534727 209 911 7 BBSome-mediated cargo-targeting to cilium R-HSA-5620922 6.26168311500204 5.23874004890806 332 420 3 Beta defensins R-HSA-1461957 5.07816276212228 5.17234724495362 47 65 1 Beta-catenin phosphorylation cascade R-HSA-196299 5.46016753441551 5.2417614682648 698 930 1 Beta-oxidation of very long chain fatty acids R-HSA-390247 6.898 5.16 5 10 1 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 6.02486932895074 5.09288375486728 129 145 2 Binding and entry of HIV virion R-HSA-173107 6.73221697234887 5.04785743982825 105 118 2 Binding of TCF/LEF:CTNNB1 to target gene promoters R-HSA-4411364 5.87 5.3 1 2 1 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-141333 5.46909333502197 5.22635664100444 346 439 1 Biotin transport and metabolism R-HSA-196780 6.3460125495823 5.19316614270162 122 130 2 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108 5.70164470140548 5.35427950008165 875 4279 9 Branched-chain amino acid catabolism R-HSA-70895 5.6375 5.2815625 4 5 1 Breakdown of the nuclear lamina R-HSA-352238 5.05112218680002 5.39725595238095 56 56 1 Budding and maturation of HIV virion R-HSA-162588 6.83044981096182 5.0226179245283 53 66 1 Butyrophilin (BTN) family interactions R-HSA-8851680 5.78777936757681 5.34375 2 2 1 B-WICH complex positively regulates rRNA expression R-HSA-5250924 5.27769614251462 5.28341932482834 2617 4842 2 Ca2+ activated K+ channels R-HSA-1296052 5.80492050499778 5.18505458775353 38 61 5 Ca2+ pathway R-HSA-4086398 5.56990655328138 5.32136126968845 271 1101 10 Calcitonin-like ligand receptors R-HSA-419812 6.08733944994422 5.46801769048464 95 198 5 Calnexin/calreticulin cycle R-HSA-901042 6.8803738003628 5.02499999999999 1 1 1 Carboxyterminal post-translational modifications of tubulin R-HSA-8955332 5.07461873774921 5.1806635617168 1677 35669 25 Cargo concentration in the ER R-HSA-5694530 6.31239785652582 5.26364155321782 127 180 4 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825 5.83252387631136 5.30299790144961 203 271 6 CASP8 activity is inhibited R-HSA-5218900 5.31185147249463 5.29019810770721 49 57 4 Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870 5.20514997559283 5.32923621038564 962 1033 4 Catabolism of glucuronate to xylulose-5-phosphate R-HSA-5661270 5.98894402317854 5.18679166666667 6 6 1 Catecholamine biosynthesis R-HSA-209905 5.68558763663958 5.27237471158015 26 37 1 CD209 (DC-SIGN) signaling R-HSA-5621575 5.34176410024677 5.26799913759907 2024 9195 5 CD28 co-stimulation R-HSA-389356 5.03553250476568 5.25270195578231 98 150 1 CD28 dependent PI3K/Akt signaling R-HSA-389357 6.42195496503171 5.21149035483751 1301 2110 6 CD28 dependent Vav1 pathway R-HSA-389359 5.13081128786115 5.33889294466125 15 21 1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 5.59553308939243 5.41250741899017 1004 2965 5 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017 5.54641736063688 5.53098436906548 848 2167 3 CDO in myogenesis R-HSA-375170 5.29227500641147 5.25104042209977 1158 2880 5 CDT1 association with the CDC6:ORC:origin complex R-HSA-68827 5.45197386789989 5.54483948705534 12619 15952 3 Cell surface interactions at the vascular wall R-HSA-202733 5.93415483343463 5.22928507311437 1012 1699 10 Cell-extracellular matrix interactions R-HSA-446353 6.27571428571429 5.11713095238095 35 35 1 Cellular hexose transport R-HSA-189200 6.98900494485035 5.30079593536736 241 283 3 Ceramide signalling R-HSA-193681 5.71956531785309 5.17371527777778 4 4 2 cGMP effects R-HSA-418457 5.93626241107727 5.25754491556067 796 1438 7 Chemokine receptors bind chemokines R-HSA-380108 6.75651330177998 5.23598568227229 241 279 6 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035 5.31421519279335 5.21413516048328 1313 2835 5 CHL1 interactions R-HSA-447041 7.07970177393478 5.24036471010209 112 302 2 Cholesterol biosynthesis R-HSA-191273 5.95780734262007 5.22287984340424 51 77 2 Cholesterol biosynthesis via desmosterol R-HSA-6807047 6.6025 5.235625 4 5 1 Cholesterol biosynthesis via lathosterol R-HSA-6807062 6.6025 5.235625 4 5 1 ChREBP activates metabolic gene expression R-HSA-163765 6.13614885547719 5.25101994968043 253 328 3 Chylomicron clearance R-HSA-8964026 6.45666666666667 5.24245520833333 82 84 3 Cilium Assembly R-HSA-5617833 5.09275574074934 5.19364887020374 1174 21191 13 Circadian Clock R-HSA-400253 5.66046025751539 5.35919715148819 1090 7338 10 Citric acid cycle (TCA cycle) R-HSA-71403 5.46681148312568 5 4 4 1 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 6.78170031550907 5.24217337439131 627 974 7 Class B/2 (Secretin family receptors) R-HSA-373080 6.0320382376666 5.30787136949309 171 352 4 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 5.99301496629237 5.23013465402134 371 527 2 Classical antibody-mediated complement activation R-HSA-173623 5.22920062310299 5.49703125 16 16 1 Clathrin-mediated endocytosis R-HSA-8856828 5.723579534199 5.28917574584348 238 317 8 CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607763 5.01357142857143 5.0375 2 13 1 CLEC7A (Dectin-1) signaling R-HSA-5607764 5.50717477834781 5.34141876446656 2644 10080 10 CLEC7A/inflammasome pathway R-HSA-5660668 5.36330249926241 5.32030844894497 1892 9003 4 Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 5.40297777042172 5.34080507129997 372 851 4 Coenzyme A biosynthesis R-HSA-196783 6.19333333333333 5.14277777777778 8 9 3 Collagen biosynthesis and modifying enzymes R-HSA-1650814 7.05821477787219 5.05242788461538 31 33 2 Collagen degradation R-HSA-1442490 5.75522468028546 5.42015540831605 3309 4316 22 Common Pathway of Fibrin Clot Formation R-HSA-140875 5.94922692027049 5.25195909469861 1125 1301 5 Condensation of Prometaphase Chromosomes R-HSA-2514853 5.42452155151169 5.22292892216687 1024 3441 5 Condensation of Prophase Chromosomes R-HSA-2299718 5.25265285246997 5.20845734258035 706 2029 2 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 6.05426407561011 5.23471969392076 2003 3042 13 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 5.63392375001947 5.23477866970039 1804 2560 6 Constitutive Signaling by EGFRvIII R-HSA-5637810 5.8352017796254 5.23709854269423 876 1374 4 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 5.8352017796254 5.23709854269423 876 1374 4 Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 6.01857307447727 5.4769669583375 143 182 2 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 5.61994649032524 5.33216032439333 5310 41902 17 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 5.61994649032524 5.33216032439333 5310 41902 17 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 6.01857307447727 5.4769669583375 143 182 2 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-6814122 5.53702966385348 5.27569576367781 209 792 2 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811434 5.09307143600436 5.18962732492879 939 17951 13 COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-204005 6.31239785652582 5.26364155321782 127 180 4 COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811436 5.12425283947747 5.18757969300111 864 17867 14 COPI-mediated anterograde transport R-HSA-6807878 5.13931288886142 5.18583034780461 841 17842 13 Costimulation by the CD28 family R-HSA-388841 6.24450890827442 5.17870805524554 611 1073 4 CREB phosphorylation through the activation of CaMKII R-HSA-442729 5.74293048400328 5.23679578328328 222 1785 5 CREB phosphorylation through the activation of CaMKK R-HSA-442717 5.33487858567028 5.25176666666667 25 32 1 CREB phosphorylation through the activation of Ras R-HSA-442742 5.49993093187247 5.23423480522765 322 506 2 CRMPs in Sema3A signaling R-HSA-399956 5.4411195858248 5.25613754635457 1182 2272 3 Crosslinking of collagen fibrils R-HSA-2243919 6.88912186343669 5.04375 18 19 1 Cross-presentation of particulate exogenous antigens (phagosomes) R-HSA-1236973 6.31510137955169 5.3093821253791 192 583 3 Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978 5.82805032979813 5.52940866420437 49 142 6 CTLA4 inhibitory signaling R-HSA-389513 5.03553250476568 5.25270195578231 98 150 1 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273 5.51695697739006 5.22019343741228 3372 9822 14 Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 5.60596478050805 5.22977924768736 1534 4238 6 Cyclin D associated events in G1 R-HSA-69231 5.75389916950139 5.244870737706 1804 4182 9 Cyclin E associated events during G1/S transition R-HSA-69202 5.59895881925749 5.23893750122663 1344 3815 6 CYP2E1 reactions R-HSA-211999 5.629626667534 5.17418677226724 43 52 2 Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 6.05817361780976 5.25654405737705 122 152 1 Cytosolic sulfonation of small molecules R-HSA-156584 5.55242078435815 5.28125 3 6 2 Cytosolic tRNA aminoacylation R-HSA-379716 6.72064393726402 5.43471875 11 11 2 DAG and IP3 signaling R-HSA-1489509 5.34106637282408 5.16620594924609 139 890 2 DAP12 signaling R-HSA-2424491 5.86379885105541 5.2394646434717 1222 1809 7 DARPP-32 events R-HSA-180024 5.68826259052607 5.28749815685877 905 3504 4 DCC mediated attractive signaling R-HSA-418885 5.13081128786115 5.33889294466125 30 42 2 Deactivation of the beta-catenin transactivating complex R-HSA-3769402 5.64484523004787 5.32353773046341 591 3630 3 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761 5.77577107745044 5.42058722747208 1777 8614 5 Dectin-2 family R-HSA-5621480 5.87936342249498 5.40439503722084 809 975 5 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) R-HSA-5683678 5.95424250943933 5.4625 1 1 1 Defective ABCC8 can cause hypoglycemias and hyperglycemias R-HSA-5683177 5.9186975482137 5.2494406208664 60 354 2 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) R-HSA-5619099 5.81145028315215 5.25385679200542 127 147 2 Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-5083635 5.31506202571527 5.35539236972705 44 47 2 Defective CFTR causes cystic fibrosis R-HSA-5678895 5.46449715871948 5.52846316174207 85 189 3 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) R-HSA-5688890 5.95424250943933 5.4625 1 1 1 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) R-HSA-5688849 5.95424250943933 5.4625 1 1 1 Defective HLCS causes multiple carboxylase deficiency R-HSA-3371599 6.18910099874142 5.08204040262046 15 19 1 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG R-HSA-3359469 5.26884531229258 5.3125 1 1 1 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE R-HSA-3359467 5.26884531229258 5.3125 1 1 1 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) R-HSA-5687868 5.95424250943933 5.4625 1 1 1 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619110 5.7535940143937 5.47049467519636 59 87 1 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) R-HSA-5619058 5.7535940143937 5.47049467519636 59 87 1 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) R-HSA-5619107 5.73836853308839 5.23869620448351 76 108 2 Degradation of AXIN R-HSA-4641257 5.77183112035164 5.46034852553427 144 315 4 Degradation of beta-catenin by the destruction complex R-HSA-195253 5.53716649181566 5.52273781783034 743 1068 3 Degradation of DVL R-HSA-4641258 5.57566597051573 5.66322599261311 45 138 2 Degradation of GLI1 by the proteasome R-HSA-5610780 5.57566597051573 5.66322599261311 45 138 2 Degradation of GLI2 by the proteasome R-HSA-5610783 5.53716649181566 5.52273781783034 743 1068 3 Degradation of the extracellular matrix R-HSA-1474228 5.98069664250607 5.3404496564763 4000 4933 37 Depolymerisation of the Nuclear Lamina R-HSA-4419969 5.4921523663856 5.24251681974374 959 3130 3 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 6.4875 5.459375 4 8 1 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803 6.13264227783898 5.26052329085429 756 1704 9 Detoxification of Reactive Oxygen Species R-HSA-3299685 5.75031835012399 5.48501130952381 32 46 5 DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3134963 5.36758601315153 5.2698897510793 2785 13299 4 Digestion of dietary carbohydrate R-HSA-189085 5.315 5.30375 6 6 1 Dimerization of procaspase-8 R-HSA-69416 5.31185147249463 5.29019810770721 49 57 4 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 5.43858876648508 5.19574184524351 1402 1866 4 Disinhibition of SNARE formation R-HSA-114516 5.97115139421688 5.31063577407051 253 1101 1 Displacement of DNA glycosylase by APEX1 R-HSA-110357 5.84832553209277 5.3102296054936 5501 5659 1 Dissolution of Fibrin Clot R-HSA-75205 5.27272221483703 5.42491432607627 152 167 3 DNA Damage Recognition in GG-NER R-HSA-5696394 6.37982928970075 5.23999562925354 309 415 2 DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586 5.77224065784496 5.26372929644929 1533 4910 5 DNA methylation R-HSA-5334118 5.33443875151028 5.240625 8 24 1 Dopamine clearance from the synaptic cleft R-HSA-379401 5.10645856654761 5.218810991891 322 468 1 Dopamine Neurotransmitter Release Cycle R-HSA-212676 5.36333333333333 5.37208333333333 6 6 1 Dopamine receptors R-HSA-390651 5.53657104391018 5.26154779089601 747 1118 2 Downregulation of ERBB2 signaling R-HSA-8863795 5.43904807993022 5.30780437403718 284 474 1 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 5.81736837687309 5.35902534800943 13339 17042 8 Downregulation of TGF-beta receptor signaling R-HSA-2173788 5.64694008715029 5.24624018653228 6460 6844 5 Downstream signal transduction R-HSA-186763 5.80380706081741 5.32618873092735 1265 1929 9 Downstream signaling of activated FGFR1 R-HSA-5654687 6.02721299196521 5.11361295981028 133 138 3 Downstream TCR signaling R-HSA-202424 5.58309464425191 5.29272895676805 3339 11970 14 DSCAM interactions R-HSA-376172 5.14302271632683 5.30264330875038 150 424 2 Dual Incision in GG-NER R-HSA-5696400 6.18471325144725 5.17249708616903 326 432 3 Dual incision in TC-NER R-HSA-6782135 5.78516003186683 5.2247205000473 230 473 4 E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 5.25265285246997 5.20845734258035 706 2029 2 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-8866654 5.65016657646837 5.25774077868852 162 203 2 Early Phase of HIV Life Cycle R-HSA-162594 6.83044981096182 5.0226179245283 53 66 1 ECM proteoglycans R-HSA-3000178 6.6441289357313 5.24525744279749 925 2434 10 Effects of PIP2 hydrolysis R-HSA-114508 5.25762885913505 5.7432800970679 557 2840 5 EGFR Transactivation by Gastrin R-HSA-2179392 5.82901029979101 5.35856153234497 309 399 3 Elastic fibre formation R-HSA-1566948 6.54117680337164 5.23160018393624 564 1699 5 Elevation of cytosolic Ca2+ levels R-HSA-139853 5.91522140573605 5.1571760401503 173 207 4 Endogenous sterols R-HSA-211976 5.95694150663827 5.21888130918336 801 1123 5 Endosomal/Vacuolar pathway R-HSA-1236977 5.57981955957327 5.3110341475654 374 423 4 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972 5.6372362606654 5.18806014883892 911 3703 7 eNOS activation R-HSA-203615 6.31952403996511 5.31327718701859 286 476 2 Enzymatic degradation of dopamine by COMT R-HSA-379397 5.84497925168662 5.2515625 8 9 1 Enzymatic degradation of Dopamine by monoamine oxidase R-HSA-379398 5.84497925168662 5.2515625 8 9 1 EPHA-mediated growth cone collapse R-HSA-3928663 5.48325051979109 5.1984220155832 2392 3333 14 EPHB-mediated forward signaling R-HSA-3928662 5.48515755216731 5.26137561096794 1526 3215 17 EPH-ephrin mediated repulsion of cells R-HSA-3928665 5.45317823718329 5.2408344052933 1291 1800 16 EPH-ephrin mediated repulsion of cells R-MMU-3928665 5.62588577029711 5.23822934225067 166 267 5 EPH-Ephrin signaling R-HSA-2682334 5.41976610277785 5.20662476526244 758 1138 15 Ephrin signaling R-HSA-3928664 5.28543440384575 5.27657414932983 369 513 7 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-427389 5.73861854367324 5.27115393870837 769 7243 2 ERK/MAPK targets R-HSA-198753 5.1864053173745 5.32235599396745 159 435 4 ERKs are inactivated R-HSA-202670 5.29519356235274 5.36151515151515 11 15 1 ER-Phagosome pathway R-HSA-1236974 5.31095025227924 5.43333198373275 352 543 4 Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044 6.14215081081609 5.29107039592097 1425 2081 3 Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673 6.14215081081609 5.29107039592097 1425 2081 3 Estrogen biosynthesis R-HSA-193144 5.36358600441669 5.22472668383597 435 650 2 Ethanol oxidation R-HSA-71384 5.40962515000003 5.26148550724638 32 52 2 Extracellular matrix organization R-HSA-1474244 7.48 5.025 1 1 1 Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834 6.20647150975778 5.36705658127056 513 720 4 Factors involved in megakaryocyte development and platelet production R-HSA-983231 5.51922256523202 5.2669510906541 2736 11931 9 Fanconi Anemia Pathway R-HSA-6783310 6.10890725413678 5.13852083333333 27 35 2 FasL/ CD95L signaling R-HSA-75157 5.71801195058458 5.31166364295006 35 36 1 Fatty acids R-HSA-211935 6.2475 5.205078125 2 4 1 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-434316 5.71957496116828 5.31441287878788 44 65 1 Fatty acyl-CoA biosynthesis R-HSA-75105 5.93595440394274 5.28175651338672 309 450 5 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050 5.49946099607474 5.5313065342247 586 750 3 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 5.76704479207845 5.31723759305211 806 972 2 FCERI mediated Ca+2 mobilization R-HSA-2871809 5.51588700424277 5.22399172870141 808 985 3 FCERI mediated MAPK activation R-HSA-2871796 5.35073658430962 5.35179620746281 496 619 8 FCERI mediated NF-kB activation R-HSA-2871837 5.39312463787893 5.52905124239385 2773 11658 13 FCGR activation R-HSA-2029481 5.44811655078031 5.28842268535589 1036 1358 4 FGFR1b ligand binding and activation R-HSA-190370 6.02721299196521 5.11361295981028 133 138 3 FGFR1c ligand binding and activation R-HSA-190373 6.5062900635731 5.02174969927827 72 73 2 FGFR2b ligand binding and activation R-HSA-190377 6.02721299196521 5.11361295981028 133 138 3 FGFR2c ligand binding and activation R-HSA-190375 6.5062900635731 5.02174969927827 72 73 2 FGFR3 mutant receptor activation R-HSA-2033514 6.5062900635731 5.02174969927827 72 73 2 FGFR3b ligand binding and activation R-HSA-190371 6.55695824699331 5.03405172413793 29 29 1 FGFR3c ligand binding and activation R-HSA-190372 6.5062900635731 5.02174969927827 72 73 2 FGFR4 ligand binding and activation R-HSA-190322 6.5062900635731 5.02174969927827 72 73 2 FGFRL1 modulation of FGFR1 signaling R-HSA-5658623 5.76234036445117 5.15339357764646 104 109 2 Fibronectin matrix formation R-HSA-1566977 6.58637987698444 5.12109861510832 127 337 3 Formation of apoptosome R-HSA-111458 5.63678572992466 5.21234722222222 9 10 1 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 5.97726530813844 5.1979659801266 511 1031 4 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 6.1419939187634 5.19539097347061 811 1608 6 Formation of Incision Complex in GG-NER R-HSA-5696395 5.90405974137377 5.18577465173925 537 886 5 Formation of RNA Pol II elongation complex R-HSA-112382 5.97726530813844 5.1979659801266 511 1031 4 Formation of TC-NER Pre-Incision Complex R-HSA-6781823 5.7820529841757 5.28712733339639 213 456 3 Formation of the beta-catenin:TCF transactivating complex R-HSA-201722 5.68390626814219 5.27367532163085 572 3593 4 Formation of the cornified envelope R-HSA-6809371 5.87575807309147 5.12753754199596 133 174 7 Formation of the Early Elongation Complex R-HSA-113418 5.48307947626354 5.20569100009459 211 454 2 Formation of the HIV-1 Early Elongation Complex R-HSA-167158 5.48307947626354 5.20569100009459 211 454 2 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389960 5.0474324878773 5.1863344437603 768 16348 11 Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 5.85569005124943 5.23214082773191 112 152 1 Free fatty acid receptors R-HSA-444209 5.42417350764581 5.31074810606061 50 72 2 Frs2-mediated activation R-HSA-170968 5.98270193946343 5.24154246954105 157 280 3 FRS-mediated FGFR1 signaling R-HSA-5654693 5.88543150443324 5.14145971985771 136 141 4 FRS-mediated FGFR2 signaling R-HSA-5654700 5.88543150443324 5.14145971985771 136 141 4 FRS-mediated FGFR3 signaling R-HSA-5654706 6.15755572299451 5.08949979951884 75 76 3 FRS-mediated FGFR4 signaling R-HSA-5654712 6.15755572299451 5.08949979951884 75 76 3 Fructose biosynthesis R-HSA-5652227 5.9706585004851 5.19565571877033 86 99 2 Fructose catabolism R-HSA-70350 5.31026170411639 5.20274621212121 11 12 1 G alpha (12/13) signalling events R-HSA-416482 5.99520239564897 5.24035391057522 1350 2186 9 G alpha (i) signalling events R-HSA-418594 6.19138812709755 5.25044965038606 6460 9160 53 G alpha (q) signalling events R-HSA-416476 6.18179294143242 5.22181741207882 6388 8602 54 G alpha (s) signalling events R-HSA-418555 5.86966844546084 5.31501125526276 21218 26189 40 G alpha (z) signalling events R-HSA-418597 5.56143106533018 5.2973840648525 807 3927 4 G beta:gamma signalling through PI3Kgamma R-HSA-392451 6.14042530169815 5.2266229113189 2642 5383 11 G0 and Early G1 R-HSA-1538133 5.78981590248491 5.263053665929 2006 8334 6 G2 Phase R-HSA-68911 5.7318598662679 5.25503301383018 1263 3681 3 G2/M Checkpoints R-HSA-69481 5.57566597051573 5.66322599261311 45 138 2 G2/M DNA damage checkpoint R-HSA-69473 5.48259955544424 5.23642978038037 6490 6795 6 G2/M DNA replication checkpoint R-HSA-69478 5.38064964039226 5.1913618819808 875 2752 4 GAB1 signalosome R-HSA-180292 6.22083599836702 5.20779489836986 589 897 2 GABA A (rho) receptor activation R-HSA-977442 5.13028976996455 5.33166666666666 3 5 1 GABA A receptor activation R-HSA-977441 6.20021918753746 5.22068264903641 1251 16425 12 Gamma-carboxylation of protein precursors R-HSA-159740 6.01496283933229 5.31376538369148 1171 1386 5 Gap junction assembly R-HSA-190861 5.04717229626654 5.18610787678833 837 17833 12 Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-5696397 5.79448117494023 5.0375 17 17 1 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6782210 5.78516003186683 5.2247205000473 230 473 4 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 5.84024518527433 5.2625288488894 114 156 2 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505 6.3587567973685 5.19741093180382 646 868 3 Generic Transcription Pathway R-HSA-212436 5.14320987654321 5.23874719390091 81 87 1 GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 5.53716649181566 5.52273781783034 743 1068 3 Glucagon signaling in metabolic regulation R-HSA-163359 6.61 5.27 5 5 1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-381676 5.64732723678924 5.23459345651348 23788 24547 5 Glucagon-type ligand receptors R-HSA-420092 5.8238441258958 5.31424454709456 11894 12268 3 Glucocorticoid biosynthesis R-HSA-194002 6.01819243166651 5.28373047275757 525 695 4 Gluconeogenesis R-HSA-70263 5.77698870266132 5.18974950396825 46 60 2 Glucuronidation R-HSA-156588 5.08169999154871 5.30267857142857 14 63 1 Glutathione conjugation R-HSA-156590 6.02571011707862 5.27804516989087 36 43 4 Glycogen breakdown (glycogenolysis) R-HSA-70221 6.41387409298962 5.24796444546569 104 198 8 Glycolysis R-HSA-70171 6.18976749909988 5.24433685341147 70 102 1 Glycoprotein hormones R-HSA-209822 5.21403380499356 5.29620542834416 3723 3723 1 Glycosphingolipid metabolism R-HSA-1660662 5.98347096318562 5.36255221744082 122 157 4 Glyoxylate metabolism and glycine degradation R-HSA-389661 5.71865258907275 5.29753333333333 25 26 1 Golgi Associated Vesicle Biogenesis R-HSA-432722 5.32921336140753 5.24296922284587 45 56 4 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 5.34951614328384 5.18775102782625 815 2649 3 GP1b-IX-V activation signalling R-HSA-430116 5.53685141604221 5.16182009081508 189 346 2 GPVI-mediated activation cascade R-HSA-114604 6.0149699421927 5.2475871539481 3463 6376 14 GRB2 events in EGFR signaling R-HSA-179812 5.46008704183733 5.225 3 3 1 GRB2 events in ERBB2 signaling R-HSA-1963640 5.46008704183733 5.225 6 6 2 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 7.08997905039678 5.24575462150253 478 1357 3 Growth hormone receptor signaling R-HSA-982772 5.80372588513347 5.3032098671643 1477 3206 4 HATs acetylate histones R-HSA-3214847 5.54182785462982 5.26207234250433 1934 3933 4 HDACs deacetylate histones R-HSA-3214815 5.68122747402387 5.3152411372363 1703 17612 9 HDL remodeling R-HSA-8964058 6.4643124650778 5.47471431636898 171 204 3 HDMs demethylate histones R-HSA-3214842 5.31982517363131 5.27312480198606 82 131 3 HDR through Homologous Recombination (HRR) R-HSA-5685942 5.42573936734925 5.18210831449957 5929 6113 3 HDR through MMEJ (alt-NHEJ) R-HSA-5685939 6.37982928970075 5.23999562925354 309 415 2 HDR through Single Strand Annealing (SSA) R-HSA-5685938 5.50505494631134 5.20281797032339 6408 7181 6 Hedgehog ligand biogenesis R-HSA-5358346 5.46449715871948 5.52846316174207 85 189 3 Hedgehog 'off' state R-HSA-5610787 5.16220089415078 5.21282393102425 717 14888 11 Hedgehog 'on' state R-HSA-5632684 5.73439844906336 5.48962746389915 99 216 4 Heme biosynthesis R-HSA-189451 5.08333333333333 5.53333333333333 3 4 1 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5362768 5.46449715871948 5.52846316174207 85 189 3 Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 5.25777282124095 5.33821270961453 281 1143 4 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 5.42865192706804 5.32871244805339 367 1266 5 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629587 5.1103637616546 5.24730444615271 279 1133 3 Histamine receptors R-HSA-390650 6.46628670007833 5.28442034652396 323 435 2 HIV elongation arrest and recovery R-HSA-167287 6.47145114001333 5.19024096015861 300 577 2 HIV Transcription Initiation R-HSA-167161 5.7220529841757 5.20504400006306 213 457 3 Homologous DNA Pairing and Strand Exchange R-HSA-5693579 5.24136846355376 5.25441247174935 5912 6096 2 Hormone ligand-binding receptors R-HSA-375281 5.90267864469236 5.24573167055917 3796 3840 3 HSF1 activation R-HSA-3371511 5.45507424001782 5.24749876088552 866 4314 5 HSF1-dependent transactivation R-HSA-3371571 5.45852718573089 5.2906371118994 1087 1837 4 HS-GAG degradation R-HSA-2024096 6.01259482979244 5.08391129032258 31 36 1 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-3371497 5.23896938026043 5.22155580140443 1980 19924 17 Hyaluronan uptake and degradation R-HSA-2160916 5.94070033291381 5.14775 45 48 1 Hydrolysis of LPC R-HSA-1483115 5.92815434062304 5.21448784722222 24 31 1 Hydroxycarboxylic acid-binding receptors R-HSA-3296197 5.62627208840217 5.33181858093321 101 160 1 IkBA variant leads to EDA-ID R-HSA-5603029 5.16173994491806 5.23538937626728 2938 13498 5 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-5603027 5.16173994491806 5.23538937626728 2938 13498 5 IKK complex recruitment mediated by RIP1 R-HSA-937041 6.15731622406089 5.24062225359226 306 410 4 IL-6-type cytokine receptor ligand interactions R-HSA-6788467 6.46246775036713 5.28718250508231 885 2158 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-198933 6.01785029851127 5.30143555508417 366 1068 9 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-200425 5.9146050893479 5.33775877299456 230 1198 6 Inactivation of Cdc42 and Rac R-HSA-428543 5.13081128786115 5.33889294466125 15 21 1 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2514859 5.75365068131213 5.33972888861957 652 2274 9 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-HSA-997272 5.4741940857008 5.31862125054201 6 24 3 Inhibition of PKR R-HSA-169131 5.04635765165609 5.14654647435898 26 29 1 Initial triggering of complement R-HSA-166663 5.59172156627116 5.479765625 17 17 2 InlB-mediated entry of Listeria monocytogenes into host cell R-HSA-8875360 5.21012525954876 5.28535865744739 1040 1400 2 Insulin effects increased synthesis of Xylulose-5-Phosphate R-HSA-163754 6.98726037020978 5.51553240740741 9 19 1 Insulin processing R-HSA-264876 5.5425 5.238125 6 7 1 Insulin receptor signalling cascade R-HSA-74751 5.46008704183733 5.225 3 3 1 Integration of provirus R-HSA-162592 6.83044981096182 5.0226179245283 53 66 1 Integrin alphaIIb beta3 signaling R-HSA-354192 6.40739638865376 5.77090029151194 882 1844 5 Integrin cell surface interactions R-HSA-216083 6.54611524551355 5.2413570209379 2627 6214 23 Interaction between L1 and Ankyrins R-HSA-445095 5.60073221114879 5.27960215459268 368 492 8 Interaction between PHLDA1 and AURKA R-HSA-8854521 5.34705104719274 5.26746761744788 541 612 1 Interactions of Tat with host cellular proteins R-HSA-176034 6.47145114001333 5.19024096015861 300 577 2 Interconversion of nucleotide di- and triphosphates R-HSA-499943 5.4623960727699 5.33191641691642 78 125 2 Interferon alpha/beta signaling R-HSA-909733 6.9489707868587 5.30143538232169 279 708 1 Interferon gamma signaling R-HSA-877300 6.19102384962121 5.22546125741445 969 2362 4 Interleukin receptor SHC signaling R-HSA-912526 6.13957898538851 5.22863365806686 2383 4942 9 Interleukin-1 family signaling R-HSA-446652 5.45874336434163 5.32124330398211 2349 9761 12 Interleukin-1 processing R-HSA-448706 5.2048846671189 5.28247272552843 2673 13147 3 Interleukin-10 signaling R-HSA-6783783 6.19958861554444 5.24250928319367 458 1033 6 Interleukin-12 family signaling R-HSA-447115 6.20165261357217 5.28563026332511 1905 4459 5 Interleukin-15 signaling R-HSA-8983432 6.16272232856339 5.27888885094298 732 1730 2 Interleukin-19,20,22,24,26,28 and 29 signaling R-HSA-8854691 6.9489707868587 5.30143538232169 279 708 1 Interleukin-2 family signaling R-HSA-451927 6.03082981640174 5.29167176497935 1135 2216 3 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 6.11334136565567 5.22160685606984 2257 4662 8 Interleukin-35 Signalling R-HSA-8984722 6.46246775036713 5.28718250508231 885 2158 2 Interleukin-4 and 13 signaling R-HSA-6785807 5.9202340833683 5.24491385141399 5050 9031 33 Interleukin-6 family signaling R-HSA-6783589 6.20165261357217 5.28563026332511 1905 4459 5 Interleukin-7 signaling R-HSA-1266695 6.25773738107982 5.19428203675563 2310 5055 12 Intestinal hexose absorption R-HSA-8981373 5.85751834664425 5.35454581376375 85 107 1 Intraflagellar transport R-HSA-5620924 5.04774471781021 5.18660632412667 699 14863 10 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140837 6.44577995792997 5.30342125169882 1191 1347 7 Ion homeostasis R-HSA-5578775 5.6357580094764 5.44081391117563 338 2039 14 Ion influx/efflux at host-pathogen interface R-HSA-6803544 5 5.17916666666667 3 3 1 Ion transport by P-type ATPases R-HSA-936837 5.59937883943027 5.55693209876543 150 1768 10 IRAK1 recruits IKK complex R-HSA-937039 5.01430630596322 5.23452870475113 260 340 1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975144 5.01430630596322 5.23452870475113 260 340 1 IRAK2 mediated activation of TAK1 complex R-HSA-937042 6.11206364033476 5.23569960440317 74 138 2 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 6.11206364033476 5.23569960440317 74 138 2 IRAK4 deficiency (TLR2/4) R-HSA-5603041 5.07816276212228 5.17234724495362 47 65 1 IRE1alpha activates chaperones R-HSA-381070 6.16743816157153 5.22526829346708 162 166 2 IRF3-mediated induction of type I IFN R-HSA-3270619 6.05817361780976 5.25654405737705 122 152 1 Iron uptake and transport R-HSA-917937 5.91971238023603 5.18001260064745 80 123 3 ISG15 antiviral mechanism R-HSA-1169408 5.71790683496903 5.24246771765899 440 880 3 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 5.59861240937431 5.25689286966474 174 293 5 Josephin domain DUBs R-HSA-5689877 5.24215953512698 5.2589375 40 51 1 Kinesins R-HSA-983189 5.09307143600436 5.18962732492879 939 17951 13 KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450604 5.15523414479251 5.2663936728395 135 403 1 Laminin interactions R-HSA-3000157 7.06492692081877 5.24604577449193 380 1099 5 LDL clearance R-HSA-8964038 5.98886038118501 5.15769125303647 7530 7633 3 LDL remodeling R-HSA-8964041 5.62454735938095 5.53352192982456 19 22 1 Lectin pathway of complement activation R-HSA-166662 5.95424250943933 5.4625 1 1 1 Leukotriene receptors R-HSA-391906 5.89529631951054 5.25154888050766 61 150 2 Ligand-dependent caspase activation R-HSA-140534 5.31185147249463 5.29019810770721 49 57 4 Ligand-gated ion channel transport R-HSA-975298 6.26606907375502 5.26964158566331 1514 17766 18 Ligand-independent caspase activation via DCC R-HSA-418889 5.33955631817628 5.21242823855543 898 1042 4 Linoleic acid (LA) metabolism R-HSA-2046105 5.78039206469598 5.24717013888889 12 12 1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-HSA-446343 6.56267336075459 5.18379129740367 138 319 2 Loss of Nlp from mitotic centrosomes R-HSA-380259 5.12214709201599 5.22264678372518 1086 7645 7 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284 5.12214709201599 5.22264678372518 1086 7645 7 Lysine catabolism R-HSA-71064 7.34807692307692 5.62081730769231 13 29 1 Lysosome Vesicle Biogenesis R-HSA-432720 5.58402716712433 5.21071360924397 115 155 3 Lysosphingolipid and LPA receptors R-HSA-419408 5.90862102336263 5.24796571451532 377 473 8 Macroautophagy R-HSA-1632852 5.57521682312817 5.20922407120628 890 3663 8 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-6791226 5.190843485502 5.35714330808081 54 85 4 MAP2K and MAPK activation R-HSA-5674135 6.11161107241374 5.2579619249947 804 1867 7 MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264 5.07744134773816 5.3196572513895 1290 5116 3 MAPK1 (ERK2) activation R-HSA-112411 6.46246775036713 5.28718250508231 885 2158 2 MAPK3 (ERK1) activation R-HSA-110056 6.01453651624681 5.27061740012298 1384 3333 3 MAPK6/MAPK4 signaling R-HSA-5687128 5.44930224539715 5.42629906290724 607 1503 5 MASTL Facilitates Mitotic Progression R-HSA-2465910 5.25265285246997 5.20845734258035 706 2029 2 Meiotic recombination R-HSA-912446 5.55789584769543 5.2136304027704 7000 8643 5 Meiotic synapsis R-HSA-1221632 5.8459987818806 5.19542370838105 5509 5537 2 MET activates PI3K/AKT signaling R-HSA-8851907 6.2116993140707 5.17523711354678 1110 1599 4 MET activates PTK2 signaling R-HSA-8874081 6.80890576148366 5.15821761553031 634 1005 5 MET activates PTPN11 R-HSA-8865999 6.20256262977438 5.1426793287237 521 702 2 MET activates RAP1 and RAC1 R-HSA-8875555 5.84531218246997 5.20808386736955 536 723 3 MET activates RAS signaling R-HSA-8851805 5.9550707671287 5.17011955248246 524 705 3 MET activates STAT3 R-HSA-8875791 6.20256262977438 5.1426793287237 521 702 2 MET interacts with TNS proteins R-HSA-8875513 6.41825256511455 5.17860343329126 624 986 3 MET Receptor Activation R-HSA-6806942 6.4328195309607 5.17150844137135 524 705 3 MET receptor recycling R-HSA-8875656 6.20256262977438 5.1426793287237 521 702 2 Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 6.50163225958748 5.33188208353428 643 886 8 Metabolism of folate and pterines R-HSA-196757 6.24197390501393 5.18472222222221 11 22 3 Metabolism of ingested SeMet, Sec, MeSec into H2Se R-HSA-2408508 5.73712133613052 5.64116379310345 29 50 1 Metabolism of polyamines R-HSA-351202 5.68409152601106 5.364140625 16 16 1 Metabolism of serotonin R-HSA-380612 5.13460452522298 5.19859601449275 23 31 1 Metal ion SLC transporters R-HSA-425410 5.4262242501084 5.16316666666667 13 15 2 Metalloprotease DUBs R-HSA-5689901 5.2307606866425 5.10938055361914 5513 5547 2 Methionine salvage pathway R-HSA-1237112 6.07658655475459 5.26772321428571 14 15 1 Methylation R-HSA-156581 5.61698196670324 5.40174209770115 38 60 3 MGMT-mediated DNA damage reversal R-HSA-5657655 5.1773727814511 5.18140151515151 33 60 1 MHC class II antigen presentation R-HSA-2132295 5.50387723191312 5.22852030278723 1824 18955 24 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-HSA-190840 5.04717229626654 5.18610787678833 837 17833 12 Mineralocorticoid biosynthesis R-HSA-193993 5.55172038283644 5.29092108441499 3924 4005 3 Minus-strand DNA synthesis R-HSA-164516 6.83044981096182 5.0226179245283 53 66 1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-HSA-5358606 5.79448117494023 5.0375 34 34 2 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-HSA-5358565 5.79448117494023 5.0375 17 17 1 Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-5339716 5.46016753441551 5.2417614682648 698 930 1 Mitochondrial protein import R-HSA-1268020 5.41937423149115 5.14549338450293 286 287 2 Mitochondrial tRNA aminoacylation R-HSA-379726 6.40128787452803 5.4819375 10 10 1 Mitotic Prometaphase R-HSA-68877 5.08026667292493 5.19233436653263 1239 18334 13 Mitotic Prophase R-HSA-68875 5.25265285246997 5.20845734258035 706 2029 2 Molecules associated with elastic fibres R-HSA-2129379 6.80740763600002 5.19948091345743 574 1721 7 mRNA Capping R-HSA-72086 5.48307947626354 5.20569100009459 211 454 2 mRNA Splicing - Major Pathway R-HSA-72163 6.08506909064716 5.715625 3 5 2 mRNA Splicing - Minor Pathway R-HSA-72165 6.04013818129432 5.85 1 3 1 mTOR signalling R-HSA-165159 5.6175676637223 5.25281646717936 615 949 2 mTORC1-mediated signalling R-HSA-166208 5.42150320837059 5.25080306300186 884 1294 3 MyD88 cascade initiated on plasma membrane R-HSA-975871 5.46905913450423 5.49840909090909 11 12 1 MyD88 deficiency (TLR2/4) R-HSA-5602498 5.07816276212228 5.17234724495362 47 65 1 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 5.25434689706748 5.33252063047276 70 92 3 Na+/Cl- dependent neurotransmitter transporters R-HSA-442660 5.41082212575592 5.24804681914143 719 1021 4 NADE modulates death signalling R-HSA-205025 5.49274274684363 5.19082909847639 430 492 3 NCAM signaling for neurite out-growth R-HSA-375165 5.46008704183733 5.225 3 3 1 NCAM1 interactions R-HSA-419037 6.00608449457785 5.27316400774482 171 293 6 Neddylation R-HSA-8951664 5.6940681805913 5.42672558041504 472 954 7 Nef and signal transduction R-HSA-164944 5.1768277010299 5.30270327209914 147 257 2 Negative feedback regulation of MAPK pathway R-HSA-5674499 5.49993093187247 5.23423480522765 322 506 2 Negative regulation of FGFR1 signaling R-HSA-5654726 6.02721299196521 5.11361295981028 133 138 3 Negative regulation of FGFR2 signaling R-HSA-5654727 6.02721299196521 5.11361295981028 133 138 3 Negative regulation of FGFR3 signaling R-HSA-5654732 6.5062900635731 5.02174969927827 72 73 2 Negative regulation of FGFR4 signaling R-HSA-5654733 6.5062900635731 5.02174969927827 72 73 2 Negative regulation of MAPK pathway R-HSA-5675221 5.48664963519409 5.23115653681844 325 509 3 Negative regulation of MET activity R-HSA-6807004 6.20256262977438 5.1426793287237 521 702 2 Negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 6.24733841160921 5.25386111111111 8 14 2 Nephrin family interactions R-HSA-373753 6.01039643378885 5.23344105998438 807 1305 5 Netrin-1 signaling R-HSA-373752 5.23995865051323 5.2901080497533 263 1029 1 Neurexins and neuroligins R-HSA-6794361 5.61801390288398 5.26707004841417 914 2687 9 Neurophilin interactions with VEGF and VEGFR R-HSA-194306 5.66338455741787 5.25524622472425 870 1109 1 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314 6.20021918753746 5.22068264903641 1251 16425 12 Neutrophil degranulation R-HSA-6798695 5.76050130929523 5.29178206302069 4511 13778 55 NFG and proNGF binds to p75NTR R-HSA-205017 5.71956531785309 5.17371527777778 4 4 2 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543 5.42057073198058 5.28385704519332 306 392 3 NF-kB is activated and signals survival R-HSA-209560 5.34039573423414 5.20767156885608 2121 9317 6 NGF processing R-HSA-167060 6 5.22916666666667 2 2 2 NGF-independant TRKA activation R-HSA-187024 5.44023947308298 5.24436300602933 715 972 1 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-532668 6.06126666774489 5.14196874999999 41 52 2 Nicotinamide salvaging R-HSA-197264 6.17199845043264 5.25016145833333 40 50 1 NIK-->noncanonical NF-kB signaling R-HSA-5676590 5.91883668139278 5.45706924566648 942 4412 4 Nitric oxide stimulates guanylate cyclase R-HSA-392154 5.44333780849708 5.35766660989646 268 345 2 NOD1/2 Signaling Pathway R-HSA-168638 5.80921029467337 5.22699179211555 692 1211 11 Nonhomologous End-Joining (NHEJ) R-HSA-5693571 5.46807124997674 5.26372988374083 5685 5735 3 Non-integrin membrane-ECM interactions R-HSA-3000171 6.17688968145239 5.28412724012842 144 199 5 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957 8.0582059991328 5.096 5 5 1 NoRC negatively regulates rRNA expression R-HSA-427413 5.60880579856398 5.24571914626765 990 7725 6 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 5.53374787135647 5.31438397038831 7406 46291 17 NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096 5.9325641025641 5.566375 13 19 1 NOTCH2 intracellular domain regulates transcription R-HSA-2197563 7.51 5.175 2 2 1 Notch-HLH transcription pathway R-HSA-350054 5.09522475061374 5.32507718139188 1919 3912 1 NR1D1 (REV-ERBA) represses gene expression R-HSA-1368071 5.83386299576652 5.3968019100187 604 6412 6 NRAGE signals death through JNK R-HSA-193648 5.52331397452245 5.22877450007227 19 25 3 NRIF signals cell death from the nucleus R-HSA-205043 5.71956531785309 5.17371527777778 8 8 4 Nuclear import of Rev protein R-HSA-180746 6.4875 5.459375 8 16 2 Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 5.34951614328384 5.18775102782625 815 2649 3 Nuclear Receptor transcription pathway R-HSA-383280 5.73501578111192 5.24541033414494 1581 2393 15 Nuclear signaling by ERBB4 R-HSA-1251985 6.42838117781154 5.46599816108664 253 351 4 O-glycosylation of TSR domain-containing proteins R-HSA-5173214 5.31506202571527 5.35539236972705 44 47 2 Oncogene Induced Senescence R-HSA-2559585 6.05867188501523 5.24614883021599 513 902 3 Orc1 removal from chromatin R-HSA-68949 5.66938230796703 5.41831020534335 1308 3819 5 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 5.82141769067505 5.1200013604103 369 478 4 Organic anion transport R-HSA-561048 5.7324696732488 5.44598086068351 22 23 2 Organic cation transport R-HSA-549127 5.22912615700987 5.18 3 3 1 Other interleukin signaling R-HSA-449836 5.9940341958417 5.26324606109765 705 1196 2 Other semaphorin interactions R-HSA-416700 6.84963243579489 5.25045164242639 103 284 1 Ovarian tumor domain proteases R-HSA-5689896 5.29177802874733 5.24656504435738 601 1324 4 Oxidative Stress Induced Senescence R-HSA-2559580 5.54193936947745 5.29728736445363 933 1736 15 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234162 5.44927243793581 5.36164185859891 330 671 2 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176 6.08428345123083 5.39473733228701 625 1105 13 p130Cas linkage to MAPK signaling for integrins R-HSA-372708 7.08997905039678 5.24575462150253 478 1357 3 P2Y receptors R-HSA-417957 6.02012269836961 5.29320394736842 138 195 5 p38MAPK events R-HSA-171007 5.30766059331492 5.24569683641975 276 812 4 p53-Dependent G1 DNA Damage Response R-HSA-69563 5.77224065784496 5.26372929644929 1533 4910 5 p75NTR negatively regulates cell cycle via SC1 R-HSA-193670 5.73643761391196 5.23611216593901 1067 10435 5 p75NTR recruits signalling complexes R-HSA-209543 5.5282420283063 5.18564108586811 319 430 6 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955 6.06836576362855 5.26808366834295 1429 3340 9 Pausing and recovery of HIV elongation R-HSA-167290 6.47145114001333 5.19024096015861 300 577 2 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238 6.47145114001333 5.19024096015861 300 577 2 PCNA-Dependent Long Patch Base Excision Repair R-HSA-5651801 5.8214033535165 5.1738648027468 5518 5676 2 PCP/CE pathway R-HSA-4086400 5.13081128786115 5.33889294466125 15 21 1 PDE3B signalling R-HSA-165160 5.53978457365957 5.30474242032743 366 920 2 PECAM1 interactions R-HSA-210990 6.37699174786229 5.2865599191371 525 1485 3 Pentose phosphate pathway (hexose monophosphate shunt) R-HSA-71336 6.98726037020978 5.51553240740741 9 19 1 Peptide ligand-binding receptors R-HSA-375276 6.25926688041021 5.20490028540782 5434 6684 35 PERK regulates gene expression R-HSA-381042 5.37543587372534 5.21097619047619 35 58 1 Phase 0 - rapid depolarisation R-HSA-5576892 6.1377666534158 5.2924157189572 394 631 11 Phase 1 - inactivation of fast Na+ channels R-HSA-5576894 5.21214924816342 5.06333333333333 3 3 1 Phase 2 - plateau phase R-HSA-5576893 6.85575902413341 5.29489835657978 59 214 5 Phase 4 - resting membrane potential R-HSA-5576886 6.22508424144517 5.68125 3 3 2 Phase I - Functionalization of compounds R-HSA-211945 5.86407139286546 5.20110703095773 215 270 6 Phenylalanine and tyrosine catabolism R-HSA-71182 6.82384615384615 5.41557692307692 13 13 1 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 6.02721299196521 5.11361295981028 133 138 3 Phospholipase C-mediated cascade; FGFR2 R-HSA-5654221 6.02721299196521 5.11361295981028 133 138 3 Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 6.5062900635731 5.02174969927827 72 73 2 Phospholipase C-mediated cascade; FGFR4 R-HSA-5654228 6.5062900635731 5.02174969927827 72 73 2 phospho-PLA2 pathway R-HSA-111995 5.92815434062304 5.21448784722222 24 31 1 Phosphorylation of Emi1 R-HSA-176417 5.25265285246997 5.20845734258035 706 2029 2 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200 5.71784794376676 5.27334952090871 1073 3258 3 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-170145 5.60877783531023 5.24536170324154 959 2827 3 Phosphorylation of the APC/C R-HSA-176412 5.25265285246997 5.20845734258035 706 2029 2 PI3K Cascade R-HSA-109704 6.0582115522784 5.16468781408576 944 1447 8 PI-3K cascade:FGFR1 R-HSA-5654689 6.10466219452594 5.15128573523412 722 1035 5 PI-3K cascade:FGFR2 R-HSA-5654695 6.10466219452594 5.15128573523412 722 1035 5 PI-3K cascade:FGFR3 R-HSA-5654710 6.36356303097006 5.11477229882406 661 970 4 PI-3K cascade:FGFR4 R-HSA-5654720 6.36356303097006 5.11477229882406 661 970 4 PI3K events in ERBB2 signaling R-HSA-1963642 6.22083599836702 5.20779489836986 589 897 2 PI3K events in ERBB4 signaling R-HSA-1250342 6.22083599836702 5.20779489836986 589 897 2 PI3K/AKT activation R-HSA-198203 6.11477480593515 5.20890921665365 803 1301 6 PI5P Regulates TP53 Acetylation R-HSA-6811555 5.33478605054516 5.25866617063492 52 79 2 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558 5.94538342972885 5.24986262362022 2024 3068 15 PIP3 activates AKT signaling R-HSA-1257604 6.06718345074115 5.24157063966633 2617 3990 14 PIWI-interacting RNA (piRNA) biogenesis R-HSA-5601884 5.43904807993022 5.30780437403718 284 474 1 PKMTs methylate histone lysines R-HSA-3214841 5.52762900672012 5.27507451910369 2787 13305 10 Platelet Adhesion to exposed collagen R-HSA-75892 7.07970177393478 5.24036471010209 112 302 2 Platelet Aggregation (Plug Formation) R-HSA-76009 5.6385598281209 5.2939248712753 736 879 3 Platelet degranulation R-HSA-114608 6.55369587888953 5.2588190695402 910 3298 14 Platelet homeostasis R-HSA-418346 6.21577139812426 5.19706805353374 171 194 3 Platelet sensitization by LDL R-HSA-432142 5.92815434062304 5.21448784722222 24 31 1 PLC beta mediated events R-HSA-112043 5.01357142857143 5.0375 2 13 1 PLC-gamma1 signalling R-HSA-167021 6 5.22916666666667 1 1 1 Plus-strand DNA synthesis R-HSA-164525 6.83044981096182 5.0226179245283 53 66 1 POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 6.20266137049809 5.2634069546669 5810 6074 3 Polo-like kinase mediated events R-HSA-156711 5.4679748378543 5.17598677923963 376 1577 3 Post-chaperonin tubulin folding pathway R-HSA-389977 5.0474324878773 5.1863344437603 768 16348 11 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-163125 6.07611111111111 5.18916666666666 3 8 1 Post-translational protein phosphorylation R-HSA-8957275 6.19857463796835 5.29352280547834 219 297 9 Potassium transport channels R-HSA-1296067 6.19333333333333 5.16798611111111 6 6 1 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-2892247 6.00728046957697 5.08438529554264 83 114 2 PPARA activates gene expression R-HSA-1989781 5.65000810462065 5.33652375722563 831 3917 15 PRC2 methylates histones and DNA R-HSA-212300 5.83807883280363 5.25912109375 40 80 2 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389957 5.04812633217266 5.18693862235223 630 13378 9 Pregnenolone biosynthesis R-HSA-196108 5.95237297779166 5.20451977087398 80 93 1 Pre-NOTCH Transcription and Translation R-HSA-1912408 5.39569298683889 5.25974782737164 2042 4236 2 Presynaptic depolarization and calcium channel opening R-HSA-112308 7.23 5.17916666666667 1 1 1 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616 5.56364428619457 5.20704776770644 6426 6731 5 Processing of DNA double-strand break ends R-HSA-5693607 5.56568632571879 5.24263085819697 7753 10476 9 Prolactin receptor signaling R-HSA-1170546 5.97596471387557 5.27292962784294 1212 2900 2 Prostacyclin signalling through prostacyclin receptor R-HSA-392851 5.54805926039108 5.47544871794872 52 54 2 Prostanoid ligand receptors R-HSA-391908 6.16196904527278 5.33772225160921 345 457 9 Protein methylation R-HSA-8876725 5.14034834669732 5.27894568186746 51 62 2 Protein repair R-HSA-5676934 5.54967192186827 5.47916666666667 1 1 1 Proton-coupled monocarboxylate transport R-HSA-433692 8.57 5.50166666666666 3 5 1 PTK6 Expression R-HSA-8849473 5.44927243793581 5.36164185859891 330 671 2 PTK6 promotes HIF1A stabilization R-HSA-8857538 5.74687419455455 5.3148163571125 503 948 2 PTK6 Regulates Cell Cycle R-HSA-8849470 5.75462172562787 5.24684069317236 1363 3555 4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471 5.29544916484924 5.28194647233062 18 24 2 Purine catabolism R-HSA-74259 6.87551787053438 5.35871011251129 42 58 1 Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 5.89489777556789 5.22073910290007 124 187 2 Purine salvage R-HSA-74217 6.50613987571825 5.23307737964512 111 151 5 Pyrimidine biosynthesis R-HSA-500753 5.30193737706704 5.20325556070184 94 99 1 Pyrimidine salvage R-HSA-73614 5.52171263820223 5.1546875 18 30 3 Pyruvate metabolism R-HSA-70268 6.89051025849529 5.44857142857143 10 16 2 RA biosynthesis pathway R-HSA-5365859 5.92397140415991 5.3608522798521 110 136 2 RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198 5.43533087776445 5.27275934472077 8461 8636 2 RAB geranylgeranylation R-HSA-8873719 5.60002379683558 5.16899091166376 8452 8626 1 RAF activation R-HSA-5673000 5.65879265426861 5.26009783011579 950 1982 5 RAF/MAP kinase cascade R-HSA-5673001 5.87931446802277 5.41727613552821 2669 6468 19 Rap1 signalling R-HSA-392517 5.02587802267732 6.50108776758275 168 229 2 Ras activation uopn Ca2+ infux through NMDA receptor R-HSA-442982 5.69578991030896 5.23482981940273 225 1788 6 RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953 5.46008704183733 5.225 3 3 1 Reactions specific to the complex N-glycan synthesis pathway R-HSA-975578 5.34639877731193 5.35004715861653 3732 3740 2 Receptor Mediated Mitophagy R-HSA-8934903 5.44823242880009 5.30930643504447 218 802 3 Recognition of DNA damage by PCNA-containing replication complex R-HSA-110314 5.79448117494023 5.0375 17 17 1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565 5.22157883550858 5.26377060187347 5986 6587 3 Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 5.10957119502479 5.25487753960518 1104 7669 9 Recruitment of NuMA to mitotic centrosomes R-HSA-380320 5.07958032372857 5.20083811337853 1712 21017 16 Recycling of bile acids and salts R-HSA-159418 5.82759965577935 5.32727037840644 321 385 6 Recycling pathway of L1 R-HSA-437239 5.04717229626653 5.18610787678833 1674 35666 24 Regulated proteolysis of p75NTR R-HSA-193692 5.48822768214042 5.26872323959843 1985 9128 4 Regulation by c-FLIP R-HSA-3371378 5.31185147249463 5.29019810770721 49 57 4 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 5.32438952628083 5.31810086789808 1328 2420 6 Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733 5.57566597051573 5.66322599261311 45 138 2 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 5.54017706074872 5.23640274533025 1969 5710 5 Regulation of Complement cascade R-HSA-977606 5.64966980125252 5.28743652266895 773 885 6 Regulation of FZD by ubiquitination R-HSA-4641263 5.41700999855466 5.14972222222222 3 3 1 Regulation of gene expression by Hypoxia-inducible Factor R-HSA-1234158 6.16594305423134 5.25930935548777 742 1241 4 Regulation of gene expression in beta cells R-HSA-210745 5.59488374954994 5.40841842670573 71 105 2 Regulation of Glucokinase by Glucokinase Regulatory Protein R-HSA-170822 5.73836853308839 5.23869620448351 76 108 2 Regulation of HSF1-mediated heat shock response R-HSA-3371453 5.89266068089636 5.17293437831049 725 965 3 Regulation of IFNA signaling R-HSA-912694 6.9489707868587 5.30143538232169 558 1416 2 Regulation of IFNG signaling R-HSA-877312 6.46246775036713 5.28718250508231 1770 4316 4 Regulation of insulin secretion R-HSA-422356 6.23966007592468 5.24165333067612 140 603 9 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 6.12684433734753 5.29813686562214 1227 1451 11 Regulation of KIT signaling R-HSA-1433559 5.03553250476568 5.25270195578231 98 150 1 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400206 5.74449642847999 5.35966055791062 492 3521 5 Regulation of necroptotic cell death R-HSA-5675482 6.10396282106478 5.29011232612613 198 310 5 Regulation of ornithine decarboxylase (ODC) R-HSA-350562 5.47026123920713 5.5336047863212 78 174 3 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 5.213195507315 5.21517609967986 1943 9731 10 Regulation of PTEN gene transcription R-HSA-8943724 5.70134077932087 5.28504743149997 2246 17808 9 Regulation of PTEN localization R-HSA-8948747 5.78342178222948 5.43046883903134 119 206 2 Regulation of PTEN stability and activity R-HSA-8948751 5.62117533908178 5.40053190107934 470 1311 7 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 5.37400336474379 5.46745606742306 134 408 3 Regulation of RAS by GAPs R-HSA-5658442 5.53713966095626 5.51715066174207 48 141 3 Regulation of RUNX1 Expression and Activity R-HSA-8934593 5.8749828722886 5.25188321279095 296 773 4 Regulation of RUNX3 expression and activity R-HSA-8941858 5.85047509508207 5.50447138939908 183 331 3 Regulation of signaling by CBL R-HSA-912631 5.88669143428189 5.22927208236048 3356 5268 18 Regulation of signaling by NODAL R-HSA-1433617 5.22039930470385 5.26947095280765 40 48 2 Regulation of TLR by endogenous ligand R-HSA-5686938 5.5162026357808 5.31742362247681 48 66 2 Regulation of TNFR1 signaling R-HSA-5357905 5.7083789472186 5.25302195273002 534 742 8 Regulation of TP53 Activity through Acetylation R-HSA-6804758 5.49241236244883 5.24868595913891 771 7245 3 Regulation of TP53 Activity through Methylation R-HSA-6804760 5.99886375343896 5.19090869061997 147 218 3 Regulation of TP53 Activity through Phosphorylation R-HSA-6804756 5.60567055432962 5.21783949168246 9655 16342 22 Regulation of TP53 Degradation R-HSA-6804757 5.90421175978131 5.28145447843208 2516 5999 7 Release of Hh-Np from the secreting cell R-HSA-5362798 6.10458204639043 5.38755891667501 130 163 1 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782 6.01496283933229 5.31376538369148 1171 1386 5 Removal of licensing factors from origins R-HSA-69300 5.20458966266821 5.3080664759398 12574 15814 1 Removal of the Flap Intermediate R-HSA-69166 5.79448117494023 5.0375 17 17 1 Removal of the Flap Intermediate from the C-strand R-HSA-174437 5.79448117494023 5.0375 17 17 1 Repression of WNT target genes R-HSA-4641265 5.87384606284232 5.27983775666377 948 6852 4 Resolution of Abasic Sites (AP sites) R-HSA-73933 5.84832553209277 5.3102296054936 5501 5659 1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 5.84832553209277 5.3102296054936 5501 5659 1 Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568 5.24136846355376 5.25441247174935 5912 6096 2 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554 5.24136846355376 5.25441247174935 5912 6096 2 Resolution of Sister Chromatid Cohesion R-HSA-2500257 5.13075094861722 5.19147499052519 2054 20983 16 Respiratory electron transport R-HSA-611105 5.6175 5.72265625 4 5 1 Response to elevated platelet cytosolic Ca2+ R-HSA-76005 5.97115139421688 5.31063577407051 253 1101 1 RET signaling R-HSA-8853659 6.03571357997814 5.22693010634114 1056 1777 7 Retinoid cycle disease events R-HSA-2453864 5.38317273658661 5.20238143631436 91 143 2 Retinoid metabolism and transport R-HSA-975634 5.73071772299835 5.24554348646659 196 270 5 Retinoid metabolism disease events R-HSA-6809583 5.76587541614226 5.20152777777778 9 10 1 Retrograde neurotrophin signalling R-HSA-177504 6 5.22916666666667 2 2 2 Retrograde transport at the Trans-Golgi-Network R-HSA-6811440 5.60002379683558 5.16899091166376 8452 8626 1 Reversible hydration of carbon dioxide R-HSA-1475029 6.26095081508533 5.26841277205679 2539 4302 12 Rho GTPase cycle R-HSA-194840 5.62757749895778 5.25713407622596 60 220 3 RHO GTPases activate CIT R-HSA-5625900 5.09415564393058 5.33319647233062 46 64 4 RHO GTPases Activate Formins R-HSA-5663220 5.19717010997133 5.21428651854207 1372 18660 16 RHO GTPases activate IQGAPs R-HSA-5626467 5.05360606485074 5.19786057431701 852 17854 13 RHO GTPases activate KTN1 R-HSA-5625970 5.13081128786115 5.33889294466125 15 21 1 RHO GTPases Activate NADPH Oxidases R-HSA-5668599 5.29615856785831 5.2916121250542 57 76 4 RHO GTPases activate PAKs R-HSA-5627123 5.30729130926882 5.21892867547408 121 187 3 RHO GTPases activate PKNs R-HSA-5625740 5.07514097697484 5.32527286121951 30 38 2 RHO GTPases Activate ROCKs R-HSA-5627117 5.73016745152505 5.23763984819708 754 975 3 RHO GTPases Activate WASPs and WAVEs R-HSA-5663213 5.19343965004253 5.31148403369916 453 1046 3 RIPK1-mediated regulated necrosis R-HSA-5213460 5.78854487218913 5.28490166151867 201 315 7 RIP-mediated NFkB activation via ZBP1 R-HSA-1810476 5.31339767360481 5.24492378527816 3061 13666 7 RMTs methylate histone arginines R-HSA-3214858 5.91063317316041 5.22127230650869 1031 2316 8 RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075 5.48307947626354 5.20569100009459 211 454 2 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167160 5.48307947626354 5.20569100009459 211 454 2 RNA Polymerase I Chain Elongation R-HSA-73777 5.48307947626354 5.20569100009459 211 454 2 RNA Polymerase I Promoter Escape R-HSA-73772 5.48307947626354 5.20569100009459 211 454 2 RNA Polymerase I Transcription Initiation R-HSA-73762 5.50772415809746 5.25575341179956 2899 11609 5 RNA Polymerase I Transcription Termination R-HSA-73863 5.48307947626354 5.20569100009459 211 454 2 RNA Polymerase II HIV Promoter Escape R-HSA-167162 5.7220529841757 5.20504400006306 213 457 3 RNA Polymerase II Pre-transcription Events R-HSA-674695 6.02181224651075 5.19912278410128 513 1034 5 RNA Polymerase II Promoter Escape R-HSA-73776 5.7220529841757 5.20504400006306 213 457 3 RNA polymerase II transcribes snRNA genes R-HSA-6807505 6.01298152229379 5.19824994982272 900 1702 6 RNA Polymerase II Transcription Elongation R-HSA-75955 5.97726530813844 5.1979659801266 511 1031 4 RNA Polymerase II Transcription Initiation R-HSA-75953 5.7220529841757 5.20504400006306 213 457 3 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 5.7220529841757 5.20504400006306 213 457 3 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 5.7220529841757 5.20504400006306 213 457 3 RNF mutants show enhanced WNT signaling and proliferation R-HSA-5340588 5.41700999855466 5.14972222222222 3 3 1 Role of Abl in Robo-Slit signaling R-HSA-428890 5.24955014162304 5.25100137511827 1054 2392 4 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 6.0371230699613 5.23826619211546 1607 2271 6 Role of phospholipids in phagocytosis R-HSA-2029485 5.97332969691291 5.21969954164662 1377 2711 10 RORA activates gene expression R-HSA-1368082 5.83226753134437 5.4567519270154 749 6634 9 ROS, RNS production in phagocytes R-HSA-1222556 5.26266890424854 5.35066663828156 276 364 4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8939243 5.37849956678237 5.26254717578521 211 794 3 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-8936459 6.2668032061749 5.22233915046469 951 4982 5 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236 5.48723745359277 5.39890003943808 679 1596 5 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes R-HSA-8939242 5.76261853071447 5.29250270644184 380 435 3 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-HSA-8939246 5.97115139421688 5.31063577407051 253 1101 1 RUNX3 regulates BCL2L11 (BIM) transcription R-HSA-8952158 5.02632433801179 5.29931988520536 6232 6500 1 RUNX3 regulates CDKN1A transcription R-HSA-8941855 5.02632433801179 5.29931988520536 6232 6500 1 RUNX3 Regulates Immune Response and Cell Migration R-HSA-8949275 6.30531371797163 5.35315500921289 125 399 2 RUNX3 regulates NOTCH signaling R-HSA-8941856 5.09522475061374 5.32507718139188 3838 7824 2 RUNX3 regulates p14-ARF R-HSA-8951936 5.41836516899019 5.23558183136438 420 3502 3 RUNX3 regulates WNT signaling R-HSA-8951430 5.78308061153202 5.2472092366757 124 326 2 RUNX3 regulates YAP1-mediated transcription R-HSA-8951671 5.49361490375007 5.31497794151321 144 221 2 S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358747 5.46016753441551 5.2417614682648 698 930 1 S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358749 5.46016753441551 5.2417614682648 698 930 1 S45 mutants of beta-catenin aren't phosphorylated R-HSA-5358751 5.46016753441551 5.2417614682648 698 930 1 Scavenging by Class A Receptors R-HSA-3000480 5.00739237624899 5.48552083333333 16 18 2 Scavenging by Class F Receptors R-HSA-3000484 5.43904807993022 5.30780437403718 568 948 2 Scavenging of heme from plasma R-HSA-2168880 5.7535940143937 5.47049467519636 59 87 1 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577 5.74811527209672 5.34387143213413 1969 5873 9 SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113 5.57566597051573 5.66322599261311 45 138 2 Sema3A PAK dependent Axon repulsion R-HSA-399954 5.24326156778004 5.33193615263337 487 909 3 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399955 5.13081128786115 5.33889294466125 15 21 1 Sema4D induced cell migration and growth-cone collapse R-HSA-416572 5.58032841060908 5.26295312231312 769 996 4 Sema4D mediated inhibition of cell attachment and migration R-HSA-416550 5.17046827370496 5.31212580105432 535 721 2 SeMet incorporation into proteins R-HSA-2408517 6.40128787452803 5.4819375 10 10 1 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 5.51401790061763 5.2619911709068 3511 13393 10 Separation of Sister Chromatids R-HSA-2467813 5.1463199126037 5.2551199166767 1284 18472 15 Serotonin and melatonin biosynthesis R-HSA-209931 6.51666666666667 5.00916666666667 3 3 1 Serotonin clearance from the synaptic cleft R-HSA-380615 5.55465911624095 5.21855153448736 364 497 1 Serotonin receptors R-HSA-390666 6.01364730859756 5.31864544904742 1553 2584 11 SHC1 events in EGFR signaling R-HSA-180336 5.46008704183733 5.225 3 3 1 SHC1 events in ERBB2 signaling R-HSA-1250196 5.56432417945703 5.25995594924609 140 880 2 SHC1 events in ERBB4 signaling R-HSA-1250347 5.46008704183733 5.225 3 3 1 SHC-mediated cascade:FGFR1 R-HSA-5654688 5.88543150443324 5.14145971985771 136 141 4 SHC-mediated cascade:FGFR2 R-HSA-5654699 5.88543150443324 5.14145971985771 136 141 4 SHC-mediated cascade:FGFR3 R-HSA-5654704 6.15755572299451 5.08949979951884 75 76 3 SHC-mediated cascade:FGFR4 R-HSA-5654719 6.15755572299451 5.08949979951884 75 76 3 SHC-related events triggered by IGF1R R-HSA-2428933 5.46008704183733 5.225 3 3 1 Sialic acid metabolism R-HSA-4085001 5.51271514981121 5.42575416666667 50 50 1 Signal regulatory protein family interactions R-HSA-391160 5.95424250943933 5.4625 1 1 1 Signal transduction by L1 R-HSA-445144 6.15997186325831 5.27620177673758 983 3000 8 Signaling by activated point mutants of FGFR1 R-HSA-1839122 6.5062900635731 5.02174969927827 72 73 2 Signaling by activated point mutants of FGFR3 R-HSA-1839130 6.5062900635731 5.02174969927827 72 73 2 Signaling by Activin R-HSA-1502540 5.11678073685488 5.30148674400146 6281 6560 4 Signaling by BMP R-HSA-201451 5.5770828723008 5.31811550925926 72 89 5 Signaling by BRAF and RAF fusions R-HSA-6802952 6.01388543356852 5.26587104234111 5937 7909 9 Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117 5.77095086348918 5.24447479123286 758 1151 4 Signaling by EGFR R-HSA-177929 6.01857307447727 5.4769669583375 143 182 2 Signaling by ERBB2 R-HSA-1227986 5.23729029234795 5.28025316490975 382 624 2 Signaling by FGFR1 in disease R-HSA-5655302 6.06634642609132 5.16116287786528 698 1084 6 Signaling by FGFR2 amplification mutants R-HSA-2023837 5.17980927542966 5.2351781542056 107 203 1 Signaling by FGFR2 fusions R-HSA-8853333 5.17980927542966 5.2351781542056 107 203 1 Signaling by FGFR2 IIIa TM R-HSA-8851708 6.06412980085862 5.09289251758738 179 276 3 Signaling by FGFR2 in disease R-HSA-5655253 5.88045818427095 5.17380097576803 832 1241 7 Signaling by FGFR3 fusions in cancer R-HSA-8853334 5.96725301285713 5.21352993224658 592 900 3 Signaling by FGFR3 point mutants in cancer R-HSA-8853338 6.18286783314351 5.13681783905925 664 973 5 Signaling by FGFR4 in disease R-HSA-5655291 5.96725301285713 5.21352993224658 592 900 3 Signaling by high-kinase activity BRAF mutants R-HSA-6802948 6.11161107241374 5.2579619249947 804 1867 7 Signaling by Hippo R-HSA-2028269 5.11599549790453 5.32014237008133 444 512 3 Signaling by Leptin R-HSA-2586552 5.97596471387557 5.27292962784294 1212 2900 2 Signaling by moderate kinase activity BRAF mutants R-HSA-6802946 6.06836576362855 5.26808366834295 1429 3340 9 Signaling by MST1 R-HSA-8852405 6.89333333333333 5.22916666666667 3 3 1 Signaling by NODAL R-HSA-1181150 5.12336182135782 5.2843954190065 12504 13048 4 Signaling by NOTCH3 R-HSA-1980148 5.9325641025641 5.566375 13 19 1 Signaling by NOTCH4 R-HSA-1980150 5.9325641025641 5.566375 13 19 1 Signaling by PDGF R-HSA-186797 5.63193362499642 5.59908144560942 304 440 2 Signaling by RAS mutants R-HSA-6802949 6.06836576362855 5.26808366834295 1429 3340 9 Signaling by Retinoic Acid R-HSA-5362517 5.89230245757618 5.42731825431304 157 439 7 Signaling by SCF-KIT R-HSA-1433557 5.63612614775811 5.24924987208933 2421 4086 13 Signalling to ERK5 R-HSA-198765 5.32005119342491 5.3754797979798 33 43 3 Signalling to p38 via RIT and RIN R-HSA-187706 5.97405290919515 5.24773037097823 156 279 2 Signalling to RAS R-HSA-167044 5.73004352091866 5.22708333333333 4 4 2 Signalling to STAT3 R-HSA-198745 6 5.22916666666667 1 1 1 SMAC binds to IAPs R-HSA-111463 5.21238772476587 5.32844956491182 1114 1359 5 SMAC-mediated dissociation of IAP:caspase complexes R-HSA-111464 5.21238772476587 5.32844956491182 1114 1359 5 SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3315487 5.54350412896054 5.2550868029778 6346 6672 3 SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356 5.54350412896054 5.2550868029778 6346 6672 3 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796 5.67229690692187 5.25799297434739 7111 10616 6 SMAD4 MH2 Domain Mutants in Cancer R-HSA-3311021 5.02632433801179 5.29931988520536 6232 6500 1 Smooth Muscle Contraction R-HSA-445355 6.08550397513651 5.15507810914993 84 155 2 snRNP Assembly R-HSA-191859 5.48869535207535 5.49135495985886 10166 10263 1 Sodium/Proton exchangers R-HSA-425986 5.94070033291381 5.14775 45 48 1 SOS-mediated signalling R-HSA-112412 5.46008704183733 5.225 3 3 1 Sphingolipid de novo biosynthesis R-HSA-1660661 5.24329791410411 5.33189495418462 153 923 3 Spry regulation of FGF signaling R-HSA-1295596 5.94810581839029 5.2662940752898 155 278 1 Stabilization of p53 R-HSA-69541 6.40009334421476 5.18696218297101 138 193 1 STAT6-mediated induction of chemokines R-HSA-3249367 5.66326835352326 5.43799242424242 22 44 1 Stimulation of the cell death response by PAK-2p34 R-HSA-211736 5.0390976048247 5.22505673987361 426 488 1 Stimuli-sensing channels R-HSA-2672351 5.55998626308655 5.15178424607688 226 320 3 Sulfur amino acid metabolism R-HSA-1614635 5.50298332421155 5.47683189655172 30 51 2 SUMO is proteolytically processed R-HSA-3065679 5 5.1375 1 1 1 SUMOylation of chromatin organization proteins R-HSA-4551638 5.64334663671741 5.27608018430679 1038 10389 3 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 5.54542633493418 5.21349530994331 6507 9646 6 SUMOylation of DNA replication proteins R-HSA-4615885 5.41222512000918 5.26725993045608 943 1113 2 SUMOylation of transcription factors R-HSA-3232118 5.84567797803137 5.36233269377301 248 563 2 Surfactant metabolism R-HSA-5683826 6.03214770338319 5.29906914850834 1083 1451 5 Synaptic adhesion-like molecules R-HSA-8849932 5.63774448537036 5.28421939387304 279 1931 8 Syndecan interactions R-HSA-3000170 6.83638159087263 5.21851230782298 1078 3167 11 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816 5.76750718939096 5.19667580292726 97 114 3 Synthesis of 5-eicosatetraenoic acids R-HSA-2142688 6.20149565220714 5.23226732738095 307 459 2 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866652 6.38 5.45 2 2 1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193775 5.64344198108326 5.3354545597042 94 111 1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 5.64344198108326 5.3354545597042 94 111 1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 5.51922099054163 5.3677272798521 96 113 2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670 5.97465473096866 5.24504938039093 230 263 4 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 6.04997691363003 5.22808983441558 351 531 3 Synthesis of Lipoxins (LX) R-HSA-2142700 6.20149565220714 5.23226732738095 307 459 2 Synthesis of PA R-HSA-1483166 5.93710342577615 5.31099401455027 102 121 7 Synthesis of PC R-HSA-1483191 5.53702966385348 5.27569576367781 209 792 2 Synthesis of PG R-HSA-1483148 6.67507636946424 5.2869453125 31 33 2 Synthesis of PIPs at the early endosome membrane R-HSA-1660516 5.69506288262649 5.21954166666667 20 20 2 Synthesis of PIPs at the ER membrane R-HSA-1483248 5.32699514323912 5.33847091194969 53 212 1 Synthesis of PIPs at the Golgi membrane R-HSA-1660514 5.51373207362573 5.27240939465409 84 244 4 Synthesis of PIPs at the late endosome membrane R-HSA-1660517 5.69506288262649 5.21954166666667 20 20 2 Synthesis of PIPs at the plasma membrane R-HSA-1660499 5.86503250998473 5.24935692808841 1364 2273 13 Synthesis of PIPs in the nucleus R-HSA-8847453 5.15605810742857 5.30825 10 13 1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 5.55108690066284 5.30456504854347 158 199 4 Synthesis of very long-chain fatty acyl-CoAs R-HSA-75876 5.90042731191274 5.20067377645503 25 28 2 Synthesis, secretion, and deacylation of Ghrelin R-HSA-422085 6.12570271047946 5.28315104166667 24 57 2 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 6.03177928166352 5.29504525757909 565 719 7 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) R-HSA-400511 6.00122763917378 5.3060778232401 548 700 3 T41 mutants of beta-catenin aren't phosphorylated R-HSA-5358752 5.46016753441551 5.2417614682648 698 930 1 Tachykinin receptors bind tachykinins R-HSA-380095 6.89109593906218 5.0892895968791 31 50 1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-445989 5.46282240544127 5.22943817969123 3175 13870 9 Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 5.97726530813844 5.1979659801266 511 1031 4 Tat-mediated HIV elongation arrest and recovery R-HSA-167243 6.47145114001333 5.19024096015861 300 577 2 TBC/RABGAPs R-HSA-8854214 5.27063795869332 5.37652777777778 9 10 1 TCF dependent signaling in response to WNT R-HSA-201681 5.89489090838303 5.27223109355922 120 210 6 TCF7L2 mutants don't bind CTBP R-HSA-5339700 5.87 5.3 1 2 1 Telomere Extension By Telomerase R-HSA-171319 5.11793294688411 5.23502577319588 97 165 1 Termination of translesion DNA synthesis R-HSA-5656169 5.79448117494023 5.0375 17 17 1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-1474151 5.43904807993022 5.30780437403718 284 474 1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910 5.71861219287986 5.14483362762987 3751 3771 3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496 5.77782417886717 5.27265625 5 10 2 TGF-beta receptor signaling activates SMADs R-HSA-2173789 5.83851157234744 5.28224108380386 6450 6847 4 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791 5.98638200004956 5.25911699474762 332 519 5 TGFBR1 KD Mutants in Cancer R-HSA-3656532 5.83851157234744 5.28224108380386 6450 6847 4 TGFBR1 LBD Mutants in Cancer R-HSA-3656535 6.10924065045932 5.27654815000336 218 347 3 TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790 6.10924065045932 5.27654815000336 218 347 3 TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3642279 5.37415212790925 5.27409722222222 12 15 1 The activation of arylsulfatases R-HSA-1663150 5.51562033778338 5.2789856880169 51 86 1 The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 5.38317273658661 5.20238143631436 91 143 2 The NLRP1 inflammasome R-HSA-844455 6.02486932895074 5.09288375486728 129 145 2 The NLRP3 inflammasome R-HSA-844456 5.67408408663279 5.26370258523861 558 884 8 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276 5.17710112324002 5.25157447912652 2169 21508 19 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 5.7797307173893 5.29160192130841 718 858 4 Thromboxane signalling through TP receptor R-HSA-428930 5.60468811067349 5.37494220182713 58 85 1 Thyroxine biosynthesis R-HSA-209968 5.21403380499356 5.29620542834416 3723 3723 1 Tie2 Signaling R-HSA-210993 5.77436479959364 5.22131943627002 1084 1720 7 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5676594 7.13470782684481 5.21535283180778 111 143 3 TNF signaling R-HSA-75893 5.44172178806151 5.25800574775303 217 271 4 TNFR1-induced NFkappaB signaling pathway R-HSA-5357956 5.79701632309264 5.24265679863293 573 844 9 TNFR1-induced proapoptotic signaling R-HSA-5357786 5.34507926411005 5.23903192932179 122 144 4 TNFR1-mediated ceramide production R-HSA-5626978 5.06645558323084 5.16954264322917 76 92 2 TNFR2 non-canonical NF-kB pathway R-HSA-5668541 6.26779099479177 5.36491873896243 220 361 6 TNFs bind their physiological receptors R-HSA-5669034 5.08162061927691 5.12208333333333 12 12 1 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 5.56213358640637 5.43211693548387 32 138 2 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 5.69540460672061 5.18154166666667 10 10 1 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 5.5162026357808 5.31742362247681 48 66 2 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 5.07816276212228 5.17234724495362 47 65 1 TP53 Regulates Metabolic Genes R-HSA-5628897 5.59790913449711 5.22784139883892 872 3644 7 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115 6.05354767771639 5.31399088541667 52 70 2 TP53 Regulates Transcription of Caspase Activators and Caspases R-HSA-6803207 5.05112218680002 5.39725595238095 56 56 1 TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-6803211 5 5.05 1 1 1 TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648 5.67368628539168 5.23466437766318 6517 7186 9 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116 5.77224065784496 5.26372929644929 1533 4910 5 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114 5.45623383501639 5.25220668676326 1259 2656 4 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 5.46905913450423 5.49840909090909 11 12 1 TRAF6 mediated induction of TAK1 complex R-HSA-937072 6.11206364033476 5.23569960440317 74 138 2 TRAF6 mediated NF-kB activation R-HSA-933542 5.32531350560603 5.30073823636081 3072 13674 8 Trafficking and processing of endosomal TLR R-HSA-1679131 5.79889775544158 5.2956296423735 721 823 7 Trafficking of AMPA receptors R-HSA-399719 5.6968492017903 5.31918460438473 195 339 4 Trafficking of GluR2-containing AMPA receptors R-HSA-416993 5.56180382506013 5.33670849821891 348 1318 5 TRAIL signaling R-HSA-75158 5.23933731686153 5.28513788098335 38 41 3 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277 5.87769212568464 5.25967551332754 473 3424 1 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1362300 5.61503035164542 5.24669572484083 1216 5453 3 Transcription of the HIV genome R-HSA-167172 5.7220529841757 5.20504400006306 213 457 3 Transcriptional activation of mitochondrial biogenesis R-HSA-2151201 5.48378933600003 5.32982635879515 499 3492 8 Transcriptional regulation of pluripotent stem cells R-HSA-452723 5.33762871513858 5.26559191176471 27 29 2 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 5.53132152578728 5.29386714387334 3329 16816 20 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6781827 5.7820529841757 5.28712733339639 213 456 3 Translesion Synthesis by POLH R-HSA-110320 5.5183203550336 5.14821875 57 68 2 Translesion synthesis by POLI R-HSA-5656121 5.79448117494023 5.0375 17 17 1 Translesion synthesis by POLK R-HSA-5655862 5.79448117494023 5.0375 17 17 1 Translesion synthesis by REV1 R-HSA-110312 5.79448117494023 5.0375 17 17 1 Translocation of GLUT4 to the plasma membrane R-HSA-1445148 5.16038776979066 5.20785346618175 1145 20587 20 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366 5.18644709984926 5.23934309309309 111 147 1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763 6.01496283933229 5.31376538369148 1171 1386 5 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936 5.5256460052904 5.4900625 20 27 1 Transport of organic anions R-HSA-879518 5.74509241335537 5.33946499923712 307 369 3 Transport of vitamins, nucleosides, and related molecules R-HSA-425397 8.67933333333334 5.39375 30 30 1 TRIF-mediated programmed cell death R-HSA-2562578 5.62370294498926 5.30852121541442 46 52 2 Triglyceride biosynthesis R-HSA-75109 6.8046132801931 5.28294497845762 62 73 2 Triglyceride catabolism R-HSA-163560 5.4863077545143 5.13299167768959 72 90 6 TRKA activation by NGF R-HSA-187042 6 5.22916666666667 2 2 2 TRP channels R-HSA-3295583 5.33815232561526 5.26103711014779 292 410 5 Truncations of AMER1 destabilize the destruction complex R-HSA-5467348 5.46016753441551 5.2417614682648 698 930 1 Tryptophan catabolism R-HSA-71240 6.57742445054945 5.50505857690595 36 63 3 TWIK-releated acid-sensitive K+ channel (TASK) R-HSA-1299316 6.22508424144517 5.68125 3 3 2 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 5.34666798305374 5.45629911048997 1019 1338 4 Ubiquitin-dependent degradation of Cyclin D1 R-HSA-69229 5.76538939637666 5.37099013811586 827 1788 6 Ub-specific processing proteases R-HSA-5689880 5.77946559317166 5.30299783127727 10067 14747 22 UCH proteinases R-HSA-5689603 5.68887999747532 5.44809812723856 159 310 4 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-438066 5.61694668345558 5.2840984037156 317 2002 9 Uncoating of the HIV Virion R-HSA-162585 6.83044981096182 5.0226179245283 53 66 1 Uptake and function of anthrax toxins R-HSA-5210891 5.24602508686989 5.31430422008547 49 73 2 Uptake and function of diphtheria toxin R-HSA-5336415 5.29948670773948 5.32845775661944 472 888 2 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-432040 6.08056617654927 5.24163888888889 45 57 1 Vasopressin-like receptors R-HSA-388479 6.37282539104615 5.22351686460492 195 226 3 VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399 6.18626770827923 5.14239583963485 881 1121 2 VEGF ligand-receptor interactions R-HSA-194313 6.70915085914058 5.02954545454546 11 12 1 VEGFA-VEGFR2 Pathway R-HSA-4420097 5.92926617686497 5.2592628532868 4860 8016 18 VEGFR2 mediated cell proliferation R-HSA-5218921 5.52704860551088 5.20709549969869 1128 2226 4 VEGFR2 mediated vascular permeability R-HSA-5218920 5.60166489841199 5.32577675101905 913 1443 3 Vif-mediated degradation of APOBEC3G R-HSA-180585 5.57566597051573 5.66322599261311 45 138 2 Vitamin B2 (riboflavin) metabolism R-HSA-196843 5.19452089083758 5.4625125 15 25 1 Vitamin B5 (pantothenate) metabolism R-HSA-199220 5.45547117905227 5.41462003181903 146 223 2 Vitamin D (calciferol) metabolism R-HSA-196791 6.385 5.20390625 4 4 1 Vitamins R-HSA-211916 6.20450082723656 5.38625 16 25 1 Vitamins B6 activation to pyridoxal phosphate R-HSA-964975 6.16722687557547 5.19375 2 2 1 Voltage gated Potassium channels R-HSA-1296072 5.69891169765745 5.21084245959857 93 153 6 Vpu mediated degradation of CD4 R-HSA-180534 5.57566597051573 5.66322599261311 45 138 2 vRNP Assembly R-HSA-192905 5.43904807993022 5.30780437403718 284 474 1 WNT ligand biogenesis and trafficking R-HSA-3238698 5.96147043468186 5.25345555555556 29 41 5 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 R-HSA-5340573 7.93 5.04583333333333 3 3 1 WNT mediated activation of DVL R-HSA-201688 5.40390308162997 5.26864566063369 231 838 3 WNT5A-dependent internalization of FZD4 R-HSA-5099900 5.97115139421688 5.31063577407051 253 1101 1 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 5.96799627018755 5.25747105845543 99 177 2 XBP1(S) activates chaperone genes R-HSA-381038 5.24670574704207 5.2462148295499 4872 5071 3 Xenobiotics R-HSA-211981 5.52237200698475 5.17460018745779 164 190 4 YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-2032785 5.49361490375007 5.31497794151321 144 221 2 5.57588772254416 5.30995156769631 26221 34930 136