shortName uniprot Organism scoreForTarget scoreForSMN2 countOfMolecules TotalEvents %ActualRecords Protein names Gene names BCR P11274 Homo sapiens (Human) 5.48373939083037 5.28288807189542 34 111 2.94117647058824 Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) BCR BCR1 D22S11 GBRA1 P14867 Homo sapiens (Human) 6.1649992073052 5.22422403381642 138 1351 1.44927536231884 Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) GABRA1 GSTM1 P09488 Homo sapiens (Human) 4.47 6.3375 1 1 0 Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4) GSTM1 GST1 KPCA P17252 Homo sapiens (Human) 4.30671014282615 5.26477508918408 325 1176 9.84615384615385 Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) PRKCA PKCA PRKACA CDK17 Q00537 Homo sapiens (Human) 5.66272727272727 5.33992424242424 11 14 9.09090909090909 Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2) CDK17 PCTAIRE2 PCTK2 CDK6 Q00534 Homo sapiens (Human) 5.75158131528072 5.29615835929388 107 208 11.214953271028 Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) CDK6 CDKN6 TYK2 P29597 Homo sapiens (Human) 4.24074617130362 5.24897102697738 192 414 1.04166666666667 Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) TYK2 3BHS2 P26439 Homo sapiens (Human) 5 5.33125 1 1 0 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B2 HSDB3B 5HT2A P14842 Rattus norvegicus (Rat) 5.99286868656518 5.26846252723292 166 425 0.602409638554217 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 5HT3A P23979 Mus musculus (Mouse) 5.1541885382004 5.2990625 6 8 0 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) Htr3a 5ht3 Htr3 5HT1A P19327 Rattus norvegicus (Rat) 5.81646989968653 5.29243707533159 364 604 7.41758241758242 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A) Htr1a 5ht1a 5HT1B P28564 Rattus norvegicus (Rat) 3.7286103190866 5.31064255696751 117 309 23.9316239316239 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B) Htr1b 5ht1b 5HT2C P08909 Rattus norvegicus (Rat) 6.12379874841562 5.20768355730631 107 335 0 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) Htr2c 5ht1c Htr1c 5HT1D P28565 Rattus norvegicus (Rat) 6.54569207407417 5.14339712694458 19 132 0 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) Htr1d 5HT1B P28222 Homo sapiens (Human) 6.29133249509043 5.44696944177915 103 155 0 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B) HTR1B HTR1DB 5NTD P21589 Homo sapiens (Human) 2 5.5 1 1 0 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73) NT5E NT5 NTE 5NTD P21588 Rattus norvegicus (Rat) 5.38796510698219 5.1985 5 5 0 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73) Nt5e Nt5 Nte ADA1B P18841 Mesocricetus auratus (Golden hamster) 8.7 6.225 1 1 0 Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B ADA1A P18130 Bos taurus (Bovine) 6.49921712183237 5.2559375 14 27 0 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) ADRA1A ADRA1C A1AG1 P02763 Homo sapiens (Human) 5.04575749056067 4.83854166666667 1 1 0 Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) ORM1 AGP1 AA2BR P29275 Homo sapiens (Human) 5.55252601352199 5.26631606984571 353 463 0.28328611898017 Adenosine receptor A2b ADORA2B AA2BR P29276 Rattus norvegicus (Rat) 5.75016217043842 5.28981321184099 139 342 0.719424460431655 Adenosine receptor A2b Adora2b ACES P22303 Homo sapiens (Human) 4.44967804077411 5.27254982786619 301 490 8.97009966777409 Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE ACHA3 P04757 Rattus norvegicus (Rat) 5.7887567726979 5.10864042207794 154 1100 0.649350649350649 Neuronal acetylcholine receptor subunit alpha-3 Chrna3 Acra3 ACHA5 P20420 Rattus norvegicus (Rat) 6.80651976834676 5.20998511904762 70 946 1.42857142857143 Neuronal acetylcholine receptor subunit alpha-5 Chrna5 Acra5 ACHA P04756 Mus musculus (Mouse) 2.59928237188801 5.26633333333333 7 72 0 Acetylcholine receptor subunit alpha Chrna1 Acra ACHA P02710 Tetronarce californica (Pacific electric ray) (Torpedo californica) 5.34031452662194 5.22166666666667 6 26 0 Acetylcholine receptor subunit alpha CHRNA1 ACHB P09690 Mus musculus (Mouse) 2.59928237188801 5.26633333333333 7 72 0 Acetylcholine receptor subunit beta Chrnb1 Acrb ACHB P02712 Tetronarce californica (Pacific electric ray) (Torpedo californica) 5.6525 5.2075 4 24 0 Acetylcholine receptor subunit beta CHRNB1 ACHD P02716 Mus musculus (Mouse) 2.59928237188801 5.26633333333333 7 72 0 Acetylcholine receptor subunit delta Chrnd Acrd ACHD P02718 Tetronarce californica (Pacific electric ray) (Torpedo californica) 5.68489621016323 5.18625 6 31 0 Acetylcholine receptor subunit delta chrnd ACHE P20782 Mus musculus (Mouse) 2 5.31363888888889 6 68 0 Acetylcholine receptor subunit epsilon Chrne Acre ACHE P09660 Rattus norvegicus (Rat) 5.36221444434833 4.93749999999999 4 8 0 Acetylcholine receptor subunit epsilon Chrne Achre ACHG P04760 Mus musculus (Mouse) 6.19497660321606 4.9825 1 4 0 Acetylcholine receptor subunit gamma Chrng Acrg ACHG P02714 Tetronarce californica (Pacific electric ray) (Torpedo californica) 5.6525 5.2075 4 24 0 Acetylcholine receptor subunit gamma CHRNG ACHB2 P17787 Homo sapiens (Human) 5.13010894691663 5.2182887673724 96 386 1.04166666666667 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 ACHB3 P12391 Rattus norvegicus (Rat) 6.84572371527146 5.20632335680751 71 950 1.40845070422535 Neuronal acetylcholine receptor subunit beta-3 Chrnb3 Acrb3 ACHB4 P12392 Rattus norvegicus (Rat) 5.94093106450286 5.11504378980894 157 1249 0.636942675159236 Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-2 chain) (N-alpha 2) Chrnb4 Acrb4 ACLY P16638 Rattus norvegicus (Rat) 4.24899936291398 5.88600504056541 15 15 0 ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly ACM2 P06199 Sus scrofa (Pig) 5.38831724714755 5.18685897435897 13 17 0 Muscarinic acetylcholine receptor M2 CHRM2 ACM3 P08483 Rattus norvegicus (Rat) 6.05166688649272 5.31634962776604 125 971 1.6 Muscarinic acetylcholine receptor M3 Chrm3 Chrm-3 ADA P00813 Homo sapiens (Human) 6.87833333333333 5.18125 6 7 0 Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) ADA ADA1 ADH1A P07327 Homo sapiens (Human) 4.91045299324845 5.0675 4 16 0 Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha) ADH1A ADH1 ADH1B P00325 Homo sapiens (Human) 4.86795299324845 5.0675 4 16 0 Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase subunit beta) ADH1B ADH2 ADH1E P00327 Equus caballus (Horse) 5.37991380724996 5.083125 9 42 0 Alcohol dehydrogenase E chain (EC 1.1.1.1) ADH1G P00326 Homo sapiens (Human) 4.29315768173654 5.0675 4 16 0 Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase subunit gamma) ADH1C ADH3 ADH1S P00328 Equus caballus (Horse) 5.37991380724996 5.083125 9 42 0 Alcohol dehydrogenase S chain (EC 1.1.1.1) ADHX P11766 Homo sapiens (Human) 5.68464577477709 5.324375 9 21 0 Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) ADH5 ADHX FDH AGTR1 P25104 Bos taurus (Bovine) 6.83897219562055 5.08461538461538 13 18 0 Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 AGTRA P25095 Rattus norvegicus (Rat) 6.82038556685033 5.22684007411255 59 152 0 Type-1A angiotensin II receptor (Angiotensin II type-1A receptor) (AT1A) Agtr1 Agtr1a At1a AGTRB P29089 Rattus norvegicus (Rat) 6.94432088071181 5.2183564745725 64 157 0 Type-1B angiotensin II receptor (AT3) (Angiotensin II type-1B receptor) (AT1B) Agtr1b Agtr1 At1b AGAL P06720 Escherichia coli (strain K12) 5.31841104879359 5.07625 2 2 0 Alpha-galactosidase (EC 3.2.1.22) (Melibiase) melA mel-7 b4119 JW4080 AGAL P06280 Homo sapiens (Human) 4.68870864130878 5.34586442406406 722 887 32.1329639889197 Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA ALDR P16116 Bos taurus (Bovine) 5.09922743016897 5.28376736111111 72 97 0 Aldose reductase (AR) (EC 1.1.1.21) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Aldehyde reductase) AKR1B1 ALDR P15121 Homo sapiens (Human) 5.95237297779166 5.20451977087398 80 93 2.5 Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) (Aldo-keto reductase family 1 member B1) AKR1B1 ALDR1 AK1A1 P14550 Homo sapiens (Human) 4.6 5.825 1 1 0 Alcohol dehydrogenase [NADP(+)] (EC 1.1.1.2) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1) AKR1A1 ALDR1 ALR ALDOA P00883 Oryctolagus cuniculus (Rabbit) 4.43384061983193 5.1746875 34 34 5.88235294117647 Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Muscle-type aldolase) ALDOA AMD P14925 Rattus norvegicus (Rat) 5.12954123831594 5.505375 10 13 0 Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] Pam AMPC P05364 Enterobacter cloacae 5.82113071081352 5.361015625 24 37 0 Beta-lactamase (EC 3.5.2.6) (Cephalosporinase) ampC AMPL P28839 Sus scrofa (Pig) 5.20333333333333 5.22083333333333 3 3 66.6666666666667 Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) (Fragment) LAP3 AMYB P16098 Hordeum vulgare (Barley) 2.87 4.98083333333333 3 3 0 Beta-amylase (EC 3.2.1.2) (1,4-alpha-D-glucan maltohydrolase) BMY1 AMYB AMY P06278 Bacillus licheniformis 2.92333333333333 4.98083333333333 3 3 0 Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (BLA) amyS amyL ANDR P10275 Homo sapiens (Human) 5.22262797507963 5.24065499135551 501 969 8.78243512974052 Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) AR DHTR NR3C4 ANDR P19091 Mus musculus (Mouse) 4.66811886278172 5.10616666666667 5 7 0 Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Ar Nr3c4 ANDR P15207 Rattus norvegicus (Rat) 3.20061827956989 5.21925403225806 62 105 11.2903225806452 Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) Ar Nr3c4 ANPRA P16066 Homo sapiens (Human) 6.32590290194812 4.96663265306122 49 51 0 Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) NPR1 ANPRA ANPRB P20594 Homo sapiens (Human) 4.04575749056067 5.65 1 3 0 Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB ANT3 P01008 Homo sapiens (Human) 4.32133591190809 5.30154761904762 7 30 0 Antithrombin-III (ATIII) (Serpin C1) SERPINC1 AT3 PRO0309 ANXA2 P07355 Homo sapiens (Human) 4.41666666666667 5.11583333333333 3 8 0 Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 ANX2L4 CAL1H LPC2D AOFA P21397 Homo sapiens (Human) 4.20823801448699 5.22868155575352 387 535 6.71834625322997 Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) MAOA AOFA P21396 Rattus norvegicus (Rat) 5.20012670862331 5.20641093138209 187 234 2.67379679144385 Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) Maoa AOFB P27338 Homo sapiens (Human) 5.46909333502197 5.22635664100444 346 439 3.17919075144509 Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB ARNT P27540 Homo sapiens (Human) 2 5.91 1 2 0 Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) ARNT BHLHE2 ARY1 P18440 Homo sapiens (Human) 4.86095958176011 5.05381944444445 9 9 0 Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1) NAT1 AAC1 AT2A1 P04191 Oryctolagus cuniculus (Rabbit) 7.7 6.16875 1 2 0 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) ATP2A1 ATP4A P19156 Sus scrofa (Pig) 5.62463690463079 5.255859375 16 66 0 Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) ATP4A ATP4A P09626 Rattus norvegicus (Rat) 4.66656630252599 5.56125 2 8 0 Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) Atp4a Hka ATP4B P18434 Sus scrofa (Pig) 5.66561269827284 5.26458333333333 15 64 0 Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain) (gp60-90) ATP4B VP16 P06492 Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 4.41588837474089 5.2794549086758 73 73 6.84931506849315 Tegument protein VP16 (Alpha trans-inducing protein) (Alpha-TIF) (ICP25) (Vmw65) UL48 AT1A1 P05023 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1) ATP1A1 AT1B1 P05026 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) ATP1B1 ATP1B ATTY P04694 Rattus norvegicus (Rat) 7.33978274411299 4.98749999999999 1 2 0 Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) Tat ADRB1 P18090 Rattus norvegicus (Rat) 5.56103699339691 5.2869212962963 36 67 0 Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) Adrb1 Adrb1r NPM P06748 Homo sapiens (Human) 6.4875 5.459375 4 8 0 Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) NPM1 NPM ADRB2 P10608 Rattus norvegicus (Rat) 5.21909651863024 5.33833333333333 25 53 0 Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) Adrb2 Adrb2r BGAL P23780 Mus musculus (Mouse) 3.22796597782486 5.575 2 2 0 Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) Glb1 Bgl Glb-1 BGLS P10482 Caldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum) 4.60631056008405 5.215 5 7 0 Beta-glucosidase A (EC 3.2.1.21) (Amygdalase) (Beta-D-glucoside glucohydrolase) (Cellobiase) (Gentiobiase) bglA BLAB P26918 Aeromonas hydrophila 5.82143584021856 5.42833333333333 2 2 0 Metallo-beta-lactamase type 2 (EC 3.5.2.6) (B2 metallo-beta-lactamase) (Beta-lactamase II) (Carbapenem-hydrolyzing metallo-beta-lactamase) (Metallo-beta-lactamase type II) cphA BLAB P14488 Bacillus cereus 3.69897000433602 5.05 2 2 0 Metallo-beta-lactamase type 2 (EC 3.5.2.6) (B2 metallo-beta-lactamase) (Beta-lactamase II) (Cephalosporinase) (Metallo-beta-lactamase type II) (Metallothioprotein beta-lactamase II) (Penicillinase) (Zinc-requiring beta-lactamase II) BLAB P25910 Bacteroides fragilis 5.00005525234911 5.48547916666667 15 20 0 Metallo-beta-lactamase type 2 (EC 3.5.2.6) (B2 metallo-beta-lactamase) (Beta-lactamase II) (Carbapenem and cephamycin resistance) (CCRA) (Cephalosporinase) (Imipenem-cefoxitin hydrolyzing enzyme) (Metallo-beta-lactamase type II) (Penicillinase) (Zinc-requiring beta-lactamase) ccrA cfiA BLAC P00808 Bacillus licheniformis 5.13684035435763 5.29375 2 3 0 Beta-lactamase (EC 3.5.2.6) (Penicillinase) [Cleaved into: Large exopenicillinase; Small exopenicillinase] penP blaP BLAC P00807 Staphylococcus aureus 4.54657004724926 5.33854166666667 6 6 0 Beta-lactamase (EC 3.5.2.6) (Penicillinase) blaZ BLO10 P14489 Pseudomonas aeruginosa 5.03075395813907 5.6046875 2 3 0 Beta-lactamase OXA-10 (EC 3.5.2.6) (Beta-lactamase PSE-2) bla oxa10 pse2 BMP2 P12643 Homo sapiens (Human) 4.36842105263158 4.9 1 19 0 Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) BMP2 BMP2A BMP4 P12644 Homo sapiens (Human) 6.12 5.15 1 1 0 Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) BMP4 BMP2B DVR4 CY24B P04839 Homo sapiens (Human) 5.164 5.50816666666667 5 16 40 Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (NADPH oxidase 2) (Neutrophil cytochrome b 91 kDa polypeptide) (Superoxide-generating NADPH oxidase heavy chain subunit) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome) CYBB NOX2 SIAT1 P15907 Homo sapiens (Human) 4.92991523440613 5.225 2 4 0 Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.99.1) (B-cell antigen CD75) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1) ST6GAL1 SIAT1 CNR1 P20272 Rattus norvegicus (Rat) 5.33115376179495 5.29681351915816 65 73 0 Cannabinoid receptor 1 (CB-R) (CB1) (Brain-type cannabinoid receptor) Cnr1 Skr6 ACOX1 P07872 Rattus norvegicus (Rat) 5.26066127807503 5.096 5 5 0 Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] Acox1 Acox CAN1 P07384 Homo sapiens (Human) 6.13494961312126 5.25916416672178 59 74 0 Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) CAPN1 CANPL1 PIG30 CPNS1 P04632 Homo sapiens (Human) 6.45571428571429 5.33803571428571 7 16 0 Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) CAPNS1 CAPN4 CAPNS CATD P07339 Homo sapiens (Human) 4.99987670057323 5.27272182254197 139 149 0.719424460431655 Cathepsin D (EC 3.4.23.5) [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain] CTSD CPSD CATG P08311 Homo sapiens (Human) 2.97478728179317 5.26947818812079 123 206 21.1382113821138 Cathepsin G (CG) (EC 3.4.21.20) CTSG CBPN P15169 Homo sapiens (Human) 5.5425 5.238125 6 7 0 Carboxypeptidase N catalytic chain (CPN) (EC 3.4.17.3) (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum carboxypeptidase N) (SCPN) CPN1 ACBP CDK1 P00546 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.30102999566398 4.95 1 2 0 Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1) CDC28 CDK1 HSL5 SRM5 YBR160W YBR1211 TAF1 P21675 Homo sapiens (Human) 6.2 5.20375 2 3 0 Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) TAF1 BA2R CCG1 CCGS TAF2A CD14 P10810 Mus musculus (Mouse) 2 5.1 1 1 0 Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) Cd14 TNR5 P25942 Homo sapiens (Human) 7.205 4.95 2 2 0 Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) CD40 TNFRSF5 CD4 P01730 Homo sapiens (Human) 6.89 4.95 3 3 0 T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4) CD4 CETP P22687 Oryctolagus cuniculus (Rabbit) 4.30883365047588 5.20208333333333 2 2 0 Cholesteryl ester transfer protein (Lipid transfer protein I) (Fragment) CETP CCND1 P24385 Homo sapiens (Human) 5.69616122306404 5.1944184733514 123 324 2.4390243902439 G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) CCND1 BCL1 PRAD1 CHLE P06276 Homo sapiens (Human) 4.94601654565373 5.1775663588393 133 156 3.00751879699248 Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 CAC1C P15381 Oryctolagus cuniculus (Rabbit) 6.24755410646862 5.355 7 8 14.2857142857143 Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Smooth muscle calcium channel blocker receptor) (CACB-receptor) (Voltage-gated calcium channel subunit alpha Cav1.2) CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 CAC1C P22002 Rattus norvegicus (Rat) 5.26294833360327 5.30017543859649 19 76 10.5263157894737 Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2) Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1 KCNE1 P15382 Homo sapiens (Human) 4.3516799419505 5.29877481836483 6 14 0 Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) KCNE1 KCNC1 P25122 Rattus norvegicus (Rat) 6.1 5.2175 1 1 0 Potassium voltage-gated channel subfamily C member 1 (NGK2) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) Kcnc1 SCN2A P04775 Rattus norvegicus (Rat) 5.97752805906365 5.04947420634921 42 103 0 Sodium channel protein type 2 subunit alpha (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) Scn2a Scn2a1 SCN3A P08104 Rattus norvegicus (Rat) 5.32894449932629 5.21963541666667 16 76 0 Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) Scn3a SCN5A P15389 Rattus norvegicus (Rat) 5.25563337545651 5.07999999999999 2 2 0 Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) Scn5a SCN4A P15390 Rattus norvegicus (Rat) 5.85056655106789 4.95 7 9 0 Sodium channel protein type 4 subunit alpha (Mu-1) (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) Scn4a PDE2A P14099 Bos taurus (Bovine) 4.68267170444531 5.29324074074074 9 11 0 cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) PDE2A CNCG P22571 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35) PDE6H PDE6A P11541 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1) PDE6A PDEA PDE6B P23439 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35) PDE6B PDEB PDE6C P16586 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (PDE V-C1) (cGMP phosphodiesterase 6C) PDE6C PDEA2 CNRG P04972 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35) PDE6G PDEG CNRG P18545 Homo sapiens (Human) 5.3707378730961 5.464775 25 150 0 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35) PDE6G PDEG ACACA P11497 Rattus norvegicus (Rat) 7.57 4.98875 2 2 0 Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] Acaca Acac MMP1 P03956 Homo sapiens (Human) 4.72109159254472 5.28656594141766 359 514 7.52089136490251 Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase] MMP1 CLG MMP2 P08253 Homo sapiens (Human) 5.78139256227691 5.33394467063818 339 397 5.30973451327434 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] MMP2 CLG4A MMP10 P09238 Homo sapiens (Human) 5.2202230830769 5.86815840918946 33 33 0 Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) MMP10 STMY2 COLY P17811 Yersinia pestis 5 4.95 1 2 0 Coagulase/fibrinolysin (EC 3.4.23.48) (Plasminogen activator) pla YPPCP1.07 YP_pPCP08 COMT P21964 Homo sapiens (Human) 5.84497925168662 5.2515625 8 9 0 Catechol O-methyltransferase (EC 2.1.1.6) COMT CP1A1 P04798 Homo sapiens (Human) 5.72616823310489 5.22899865591398 31 38 19.3548387096774 Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450 form 6) (Cytochrome P450-C) (Cytochrome P450-P1) CYP1A1 CP1A1 P00185 Rattus norvegicus (Rat) 3.34266799155136 5.2175 2 3 0 Cytochrome P450 1A1 (CYP1A1) (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-C) (Cytochrome P450MT2) [Cleaved into: Cytochrome P450MT2A; Cytochrome P450MT2B] Cyp1a1 Cyp1a-1 CP1A2 P05177 Homo sapiens (Human) 4.14385497265222 5.33309323941277 2529 2729 16.7655199683669 Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) CYP1A2 CP3A5 P20815 Homo sapiens (Human) 4.51486375677272 5.41196428571428 14 24 0 Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (Cytochrome P450 HLp2) (Cytochrome P450-PCN3) CYP3A5 CP2A5 P20852 Mus musculus (Mouse) 4.20414327463402 5.21666666666667 3 4 0 Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (Cytochrome P450-15-COH) (Cytochrome P450-IIA3.2) Cyp2a5 Cyp2a-5 CP2B6 P20813 Homo sapiens (Human) 4.49455114899885 5.16789545830398 50 55 6 Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1) CYP2B6 CP2B1 P00176 Rattus norvegicus (Rat) 4.53373419592721 5.15047619047619 21 22 23.8095238095238 Cytochrome P450 2B1 (EC 1.14.14.1) (CYPIIB1) (Cytochrome P450-B) (Cytochrome P450b) (Cytochrome P450-LM2) (Cytochrome P450-PB1) (Cytochrome P450-PB2) Cyp2b1 Cyp2b-1 CP2B4 P00178 Oryctolagus cuniculus (Rabbit) 2.69897000433602 5.025 1 1 0 Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 CP2BB P24460 Canis lupus familiaris (Dog) (Canis familiaris) 6.4 5.32916666666667 1 2 0 Cytochrome P450 2B11 (EC 1.14.14.1) (CYPIIB11) (Cytochrome P450 PBD-2) CYP2B11 CP2C8 P10632 Homo sapiens (Human) 5.011753335068 5.14329541953447 41 48 12.1951219512195 Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 CP2E1 P05181 Homo sapiens (Human) 2.37866762697915 5.25122657827658 96 177 27.0833333333333 Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) CYP2E1 CYP2E CP11A P00189 Bos taurus (Bovine) 4.01598136681911 5.12916666666667 5 5 0 Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc)) CYP11A1 C11B1 P15150 Bos taurus (Bovine) 5.73408619080934 5.09208333333333 3 3 0 Cytochrome P450 11B1, mitochondrial (CYPXIB1) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) CYP11B1 C11B1 P15393 Rattus norvegicus (Rat) 4 5.3175 5 7 0 Cytochrome P450 11B1, mitochondrial (CYPXIB1) (Cytochrome P450(11 beta)-DS) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) Cyp11b1 Cyp11b-1 CP17A P05093 Homo sapiens (Human) 4.83000044060811 5.22875369385343 141 177 0 Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase) CYP17A1 CYP17 S17AH CP17A P11715 Rattus norvegicus (Rat) 4.71555543689502 5.38696428571429 14 23 0 Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) Cyp17a1 Cyp17 CP19A P11511 Homo sapiens (Human) 5.55004363946636 5.25219673050379 322 516 1.24223602484472 Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) CYP19A1 ARO1 CYAR CYP19 CP19A P22443 Rattus norvegicus (Rat) 6.28449508390915 5.20076822916667 16 17 0 Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) Cyp19a1 Arom Cyp19 CRTY P21687 Pantoea ananas (Erwinia uredovora) 5.82143584021856 5.15625 2 2 0 Lycopene cyclase crtY ADCY2 P26769 Rattus norvegicus (Rat) 4.0416080054812 4.8875 4 26 0 Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) (AC2) Adcy2 ADCY3 P21932 Rattus norvegicus (Rat) 3.83 4.90416666666667 3 24 0 Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3) Adcy3 ADCY4 P26770 Rattus norvegicus (Rat) 3.83 4.90416666666667 3 24 0 Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) Adcy4 CYSP P25805 Plasmodium falciparum 5.39 5.09583333333333 6 12 0 Trophozoite cysteine proteinase (TCP) (EC 3.4.22.-) DRD2 P20288 Bos taurus (Bovine) 5.65711132925271 5.49758522727273 33 84 0 D(2) dopamine receptor (Dopamine D2 receptor) DRD2 DRD3 P19020 Rattus norvegicus (Rat) 5.59200757754802 5.36778828328486 75 469 0 D(3) dopamine receptor (Dopamine D3 receptor) Drd3 DRD1 P18901 Rattus norvegicus (Rat) 5.4764615156706 5.31693493471418 118 525 0 D(1A) dopamine receptor (Dopamine D1 receptor) Drd1 Drd1a DRD5 P25115 Rattus norvegicus (Rat) 5.29926018293636 5.36312785812335 57 470 0 D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor) Drd5 DCOR P11926 Homo sapiens (Human) 4.5805025206194 5.0425 5 5 20 Ornithine decarboxylase (ODC) (EC 4.1.1.17) ODC1 DCOR P09057 Rattus norvegicus (Rat) 2 5.06874999999999 3 3 0 Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc DDLB P07862 Escherichia coli (strain K12) 5 4.85 1 3 100 D-alanine--D-alanine ligase B (EC 6.3.2.4) (D-Ala-D-Ala ligase B) (D-alanylalanine synthetase B) ddlB ddl b0092 JW0090 DCK P27707 Homo sapiens (Human) 6.2337479250568 5.02071428571429 7 16 0 Deoxycytidine kinase (dCK) (EC 2.7.1.74) DCK AL1A1 P00352 Homo sapiens (Human) 4.53495101739155 5.34843310541274 12077 12168 34.3048770389998 Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.-) (EC 1.2.1.36) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) ALDH1A1 ALDC ALDH1 PUMB1 ALDHX P22281 Saccharomyces cerevisiae (Baker's yeast) 5 5.66 1 1 0 Aldehyde dehydrogenase 1, mitochondrial (EC 1.2.1.3) ALD1 ALDH ALDH1 CBR1 P16152 Homo sapiens (Human) 5.66912184553422 5.20833333333333 4 9 25 Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) CBR1 CBR CRN SDR21C1 NQO1 P15559 Homo sapiens (Human) 5.25945177658992 5.27436237373737 33 36 3.03030303030303 NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) NQO1 DIA4 NMOR1 DHSO P07846 Ovis aries (Sheep) 2 5.7875 1 1 0 Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD DNLI1 P18858 Homo sapiens (Human) 2.45192746210115 5.30166666666667 5 5 0 DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) LIG1 DPO3 P13267 Bacillus subtilis (strain 168) 6.04982033043576 5.40094742894309 35 39 14.2857142857143 DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC dnaF mutI BSU16580 DPO1 P19821 Thermus aquaticus 3.20459913525295 5.47258012820513 13 18 0 DNA polymerase I, thermostable (EC 2.7.7.7) (Taq polymerase 1) polA pol1 DPOL P04415 Enterobacteria phage T4 (Bacteriophage T4) 3.69897000433602 5.1 1 1 0 DNA-directed DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 43) (Gp43) 43 DPOL P04293 Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 3.30102999566398 5.14541666666667 6 6 0 DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4) UL30 DNAS1 P24855 Homo sapiens (Human) 4.01642857142857 5.48428571428571 14 14 0 Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) (Dornase alfa) DNASE1 DNL1 DRNI DRTS P07382 Leishmania major 4.72060566476932 5.3486875 10 10 0 Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] LmjF06.0860 LmjF_06_0860 DRTS P13922 Plasmodium falciparum (isolate K1 / Thailand) 5.16375 5.20807291666667 8 25 12.5 Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] DYR1 P00382 Escherichia coli 7.535 5.26102083333333 10 10 0 Dihydrofolate reductase type 1 (EC 1.5.1.3) (Dihydrofolate reductase type I) (Trimethoprim resistance protein) dhfrI DYR P00378 Gallus gallus (Chicken) 5.30847718523608 5.27203125 4 4 0 Dihydrofolate reductase (EC 1.5.1.3) DHFR DYR P16184 Pneumocystis carinii 7.29 5.88333333333333 3 3 0 Dihydrofolate reductase (EC 1.5.1.3) CEL2A P08419 Sus scrofa (Pig) 4.88191732814502 5.30469362745098 17 30 0 Chymotrypsin-like elastase family member 2A (EC 3.4.21.71) (Elastase-2) (Elastase-2A) CELA2A ELA2 ELA2A ELAS P14756 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.90744811951372 5.1125 6 6 0 Elastase (EC 3.4.24.26) (Neutral metalloproteinase) (PAE) (Pseudolysin) [Cleaved into: Pro-elastase] lasB PA3724 ELNE P08246 Homo sapiens (Human) 4.78217445611749 5.26843481505129 265 386 9.81132075471698 Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) ELANE ELA2 ENPL P14625 Homo sapiens (Human) 5.00739237624899 5.48552083333333 8 9 0 Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog) HSP90B1 GRP94 TRA1 ENV P19550 Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1) 6.12 4.95 2 2 0 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] env EPOR P19235 Homo sapiens (Human) 5.26140330172093 5.0875 8 16 0 Erythropoietin receptor (EPO-R) EPOR ERBB3 P21860 Homo sapiens (Human) 5.72192307692308 5.36823717948718 13 40 0 Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) ERBB3 HER3 EST1 P23141 Homo sapiens (Human) 5.64008320591484 5.18631944444445 33 41 3.03030303030303 Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH) CES1 CES2 SES1 ESR1 P19785 Mus musculus (Mouse) 4.73202340987544 5.09839285714286 7 22 0 Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Esr1 Esr Estr Estra Nr3a1 ESR1 P06211 Rattus norvegicus (Rat) 3.11964004305465 5.4675 5 9 0 Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) Esr1 Esr Estr Nr3a1 EDNRB P28088 Bos taurus (Bovine) 6.69352490220977 4.95 11 11 0 Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB EDNRA P21450 Bos taurus (Bovine) 6.66418827202664 4.95 7 7 0 Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) EDNRA F13A P00488 Homo sapiens (Human) 5.81919653813932 5.12822916666667 8 14 0 Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain) F13A1 F13A FA10 P00743 Bos taurus (Bovine) 7.1 5.0895 5 5 0 Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] F10 FA11 P03951 Homo sapiens (Human) 6.2001283700641 5.32033333333333 45 55 0 Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain] F11 FABP4 P15090 Homo sapiens (Human) 5.00215578611043 5.12228174603175 21 28 0 Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4) FABP4 FABPI P12104 Homo sapiens (Human) 5.36474250108401 5.009375 2 3 0 Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP) FABP2 FABPI FABPL P02692 Rattus norvegicus (Rat) 5.45636843905876 5.3375 3 7 66.6666666666667 Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver-type fatty acid-binding protein) (L-FABP) (Squalene- and sterol-carrier protein) (SCP) (Z-protein) (p14) Fabp1 FCERA P12319 Homo sapiens (Human) 4.84067431553263 5.26458333333333 4 6 0 High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha) FCER1A FCE1A FGFR2 P21802 Homo sapiens (Human) 5.17980927542966 5.2351781542056 107 203 8.41121495327103 Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) FGFR2 BEK KGFR KSAM FGFR3 P22607 Homo sapiens (Human) 4.53178886046841 5.25744966814159 226 343 3.98230088495575 Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) FGFR3 JTK4 AL5AP P20292 Homo sapiens (Human) 6.95844675259241 5.23561352380952 125 139 0 Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein) ALOX5AP FLAP FOS P01100 Homo sapiens (Human) 5.01778110995181 5.3078125 4 12 0 Proto-oncogene c-Fos (Cellular oncogene fos) (G0/G1 switch regulatory protein 7) FOS G0S7 FPPS P05369 Rattus norvegicus (Rat) 5 5.02083333333333 3 6 0 Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Cholesterol-regulated 39 kDa protein) (CR 39) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase) Fdps FUMH P10173 Sus scrofa (Pig) 7.1 5.703125 1 1 0 Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2) FH FURIN P09958 Homo sapiens (Human) 6.97741647538002 4.95503277153558 267 269 0 Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 G3PG P22513 Trypanosoma cruzi 3.84102999566398 5.2484375 2 2 0 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (GAPDH) (EC 1.2.1.12) GBRA1 P08219 Bos taurus (Bovine) 5.63092052757222 5.09972354475669 46 366 0 Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) GABRA1 GBRA2 P10063 Bos taurus (Bovine) 5.63092052757222 5.09972354475669 46 366 0 Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) GABRA2 GBRA2 P26048 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) Gabra2 Gabra-2 GBRA2 P23576 Rattus norvegicus (Rat) 6.20269510618004 5.15871146275749 307 5796 0.325732899022801 Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) Gabra2 Gabra-2 GBRA3 P10064 Bos taurus (Bovine) 5.67111370783664 5.09503084522286 47 372 0 Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) GABRA3 GBRA3 P26049 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) Gabra3 Gabra-3 GBRA3 P20236 Rattus norvegicus (Rat) 6.18197813773932 5.16025055982301 302 5744 0.33112582781457 Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) Gabra3 Gabra-3 GBRA4 P28471 Rattus norvegicus (Rat) 6.22516754068209 5.15981044430208 313 6016 0.319488817891374 Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) Gabra4 GBRA5 P19969 Rattus norvegicus (Rat) 6.20180331110739 5.15997654498344 309 5830 0.323624595469256 Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) Gabra5 Gabra-5 GBRB1 P08220 Bos taurus (Bovine) 5.71296550559005 5.10841561928071 48 378 0 Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) GABRB1 GBRB1 P15431 Rattus norvegicus (Rat) 6.22670653920992 5.15780529615347 312 6016 0.32051282051282 Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) Gabrb1 Gabrb-1 GBRB3 P28472 Homo sapiens (Human) 6.6807705750492 5.21305851715687 136 1810 0.735294117647059 Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) GABRB3 GBRG1 P23574 Rattus norvegicus (Rat) 6.21263430453638 5.16019858354393 316 6065 0.316455696202532 Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) Gabrg1 GBRG2 P22300 Bos taurus (Bovine) 5.63092052757222 5.09972354475669 46 366 0 Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) GABRG2 GBRG2 P18508 Rattus norvegicus (Rat) 6.1727811455298 5.16255532365618 300 5698 0.333333333333333 Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) Gabrg2 GBRG3 P28473 Rattus norvegicus (Rat) 6.226007746773 5.15975476952344 315 6064 0.317460317460317 Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) Gabrg3 GBRD P22933 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) Gabrd GCR P04150 Homo sapiens (Human) 4.50144020825865 5.24600010932278 231 461 16.017316017316 Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) NR3C1 GRL SSR1 P28646 Rattus norvegicus (Rat) 8.11833333333333 5.12083333333333 6 14 0 Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2) Sstr1 GCR P06537 Mus musculus (Mouse) 4.44524974054476 5.1125 1 1 0 Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) Nr3c1 Grl Grl1 GRM1 P23385 Rattus norvegicus (Rat) 4.61296550087678 5.35321759259259 81 97 0 Metabotropic glutamate receptor 1 (mGluR1) Grm1 Gprc1a Mglur1 GLHA P01215 Homo sapiens (Human) 5.21403380499356 5.29620542834416 3723 3723 16.2234756916465 Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha chain) (Luteinizing hormone alpha chain) (LSH-alpha) (Lutropin alpha chain) (Thyroid-stimulating hormone alpha chain) (TSH-alpha) (Thyrotropin alpha chain) CGA GLI1 P08151 Homo sapiens (Human) 3.14375 5.06940104166667 8 10 12.5 Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) GLI1 GLI GRIA1 P23818 Mus musculus (Mouse) 4.4050458197032 5.32439102564103 13 100 0 Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) Gria1 Glur1 GRIA3 P19492 Rattus norvegicus (Rat) 5.05174875474436 5.28532631802721 196 1020 0 Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) Gria3 Glur3 GRIA4 P19493 Rattus norvegicus (Rat) 5.03499656964369 5.27570746527778 192 1016 0 Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) Gria4 Glur4 GLRA2 P23416 Homo sapiens (Human) 4 5.0875 2 2 0 Glycine receptor subunit alpha-2 GLRA2 GLRA2 P22771 Rattus norvegicus (Rat) 2 5.31871163048191 69 552 37.6811594202899 Glycine receptor subunit alpha-2 (Glycine receptor strychnine-binding subunit) Glra2 GLRA3 P24524 Rattus norvegicus (Rat) 2 5.31871163048191 69 552 37.6811594202899 Glycine receptor subunit alpha-3 Glra3 GLRB P20781 Rattus norvegicus (Rat) 2 5.31871163048191 69 552 37.6811594202899 Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) Glrb GTR1 P11167 Rattus norvegicus (Rat) 4.94000788419249 5.17166666666667 3 4 33.3333333333333 Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) Slc2a1 Glut-1 Glut1 GTR3 P11169 Homo sapiens (Human) 5 4.8125 1 2 100 Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) SLC2A3 GLUT3 GTR4 P19357 Rattus norvegicus (Rat) 2 4.805 2 2 0 Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) Slc2a4 Glut-4 Glut4 HEM2 P13716 Homo sapiens (Human) 3.40051499783199 5.2903125 4 4 0 Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) ALAD HEXB P07686 Homo sapiens (Human) 4.7775 5.129375 4 8 0 Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 HGF P14210 Homo sapiens (Human) 7.195 5 1 2 0 Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] HGF HPTA HRH2 P25102 Rattus norvegicus (Rat) 4.8347540775686 5.303125 4 4 0 Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) Hrh2 HMOX1 P14901 Mus musculus (Mouse) 4.25 5.2875 4 4 0 Heme oxygenase 1 (HO-1) (EC 1.14.14.18) (P32 protein) Hmox1 HMOX1 P06762 Rattus norvegicus (Rat) 4.895128749458 5.45734375 8 10 0 Heme oxygenase 1 (HO-1) (EC 1.14.14.18) (HSP32) Hmox1 HMOX2 P23711 Rattus norvegicus (Rat) 4.56900651850398 5.37886904761905 7 9 0 Heme oxygenase 2 (HO-2) (EC 1.14.14.18) Hmox2 HPRT P00492 Homo sapiens (Human) 4.82454545454545 5.46477272727273 11 11 0 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HPRT1 HPRT HRP1 P05227 Plasmodium falciparum 3.85367041544787 5.37452586206896 29 30 0 Histidine-rich protein PFHRP-II HXK2 P27881 Rattus norvegicus (Rat) 4.84193184507759 5.125 1 1 0 Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) Hk2 HXK3 P27926 Rattus norvegicus (Rat) 4.94782198833493 5.125 1 1 0 Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) Hk3 HYEP P07099 Homo sapiens (Human) 6.47104166666667 5.20965972222222 24 26 4.16666666666667 Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) EPHX1 EPHX EPOX HYEP P07687 Rattus norvegicus (Rat) 2 5.9375 1 1 0 Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) Ephx1 Eph-1 I23O1 P14902 Homo sapiens (Human) 4.18053807831708 5.21958806818182 88 110 2.27272727272727 Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase) IDO1 IDO INDO IAPP P10997 Homo sapiens (Human) 5 5.5725 1 3 0 Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide) IAPP IL2RA P01590 Mus musculus (Mouse) 3.24607625286837 4.84375 4 4 0 Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (p55) (CD antigen CD25) Il2ra Il2r IL5 P04401 Mus musculus (Mouse) 5.10911730053559 5.67134468632008 2 4 0 Interleukin-5 (IL-5) (B-cell growth factor II) (BCGF-II) (Cytotoxic T-lymphocyte inducer) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF) Il5 Il-5 IL8 P10145 Homo sapiens (Human) 4.6569997567386 5.29521205357143 56 78 25 Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)] CXCL8 IL8 ILVB P17597 Arabidopsis thaliana (Mouse-ear cress) 5.43623379636661 5.49780491362842 27 46 3.7037037037037 Acetolactate synthase, chloroplastic (AtALS) (EC 2.2.1.6) (Acetohydroxy-acid synthase) (Protein CHLORSULFURON RESISTANT 1) ALS AHAS CSR1 TZP5 At3g48560 T8P19.70 IMDH2 P12268 Homo sapiens (Human) 5.97213149154762 5.25961477987421 106 148 0.943396226415094 Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II) IMPDH2 IMPD2 INSR P15127 Rattus norvegicus (Rat) 2 5.26124904899924 81 162 30.8641975308642 Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Insr ITA2 P17301 Homo sapiens (Human) 7.30977111207467 5.23027777777778 9 18 0 Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) ITGA2 CD49B ITB5 P18084 Homo sapiens (Human) 6.77547663030035 5.15120967741935 31 72 0 Integrin beta-5 ITGB5 ITB7 P26010 Homo sapiens (Human) 6.73696574429996 5.27694444444445 21 42 0 Integrin beta-7 (Gut homing receptor beta subunit) ITGB7 ABL P00521 Abelson murine leukemia virus 3.9002423553362 5.490625 4 4 0 Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl) ABL KLK2 P20151 Homo sapiens (Human) 5.47 4.95 1 1 0 Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2) KLK2 KLKB1 P03952 Homo sapiens (Human) 4.87116497377564 5.17157552083333 48 48 0 Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] KLKB1 KLK3 CSK22 P19784 Homo sapiens (Human) 5.6301186868581 5.27537202380952 115 411 7.82608695652174 Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) CSNK2A2 CK2A2 KCC2A P11275 Rattus norvegicus (Rat) 3.73822263035266 5.23527777777778 9 36 0 Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) Camk2a KCC2B P08413 Rattus norvegicus (Rat) 3.73822263035266 5.23527777777778 9 36 0 Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) Camk2b KCC2D P15791 Rattus norvegicus (Rat) 3.73822263035266 5.23527777777778 9 36 0 Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) Camk2d KCC2G P11730 Rattus norvegicus (Rat) 3.73822263035266 5.23527777777778 9 36 0 Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) Camk2g KCRM P06732 Homo sapiens (Human) 4.52287874528034 5.825 1 1 0 Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (M-CK) CKM CKMM KCRM P00563 Oryctolagus cuniculus (Rabbit) 4.81453941702932 5.18 2 2 0 Creatine kinase M-type (EC 2.7.3.2) (Creatine kinase M chain) (M-CK) CKM FGR P09769 Homo sapiens (Human) 4.71296131005846 5.22752083333333 75 125 13.3333333333333 Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) FGR SRC2 KGP1 P00516 Bos taurus (Bovine) 6.36666666666667 5.02083333333333 3 3 0 cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B KIN28 P06242 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.30102999566398 4.95 1 1 0 Serine/threonine-protein kinase KIN28 (EC 2.7.11.23) KIN28 YDL108W D2330 KIPN P06855 Enterobacteria phage T4 (Bacteriophage T4) 2.56632333477867 4.97916666666667 3 3 0 Polynucleotide kinase (PNK) (EC 2.7.1.78) (Deoxynucleotide 3'-phosphatase) (EC 3.1.3.34) (Polynucleotide 5'-hydroxyl-kinase) pseT KITH P09768 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 5.15607739813673 5.58125 1 2 0 Thymidine kinase, cytosolic (EC 2.7.1.21) TK1 KITH P06479 Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus 1) 5.02048590677412 5.33329710144927 23 32 0 Thymidine kinase (EC 2.7.1.21) TK UL23 KIT P10721 Homo sapiens (Human) 4.62249442018802 5.23487661474164 235 479 3.40425531914894 Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) KIT SCFR LYN P07948 Homo sapiens (Human) 4.09208290162609 5.21515264026403 202 320 4.95049504950495 Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) LYN JTK8 PHKG2 P15735 Homo sapiens (Human) 3.63420715940018 5.25013306451613 155 210 5.16129032258065 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) PHKG2 KPCA P04409 Bos taurus (Bovine) 7.45 5.3925 5 5 0 Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) PRKCA KPCA P20444 Mus musculus (Mouse) 6.62482094293035 5.17606837606838 13 16 0 Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) Prkca Pkca KPCA P05696 Rattus norvegicus (Rat) 6.17885343360504 5.34780303030303 22 163 4.54545454545455 Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) Prkca Pkca KPCD P09215 Rattus norvegicus (Rat) 5.87183029154268 5.17179824561403 19 160 5.26315789473684 Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] Prkcd Pkcd KPCE P16054 Mus musculus (Mouse) 5.93736531031023 5.28765625 4 7 0 Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) Prkce Pkce Pkcea KPCE P09216 Rattus norvegicus (Rat) 5.79923877696554 5.17570833333333 20 192 5 Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) Prkce Pkce KPCZ P09217 Rattus norvegicus (Rat) 5.79923877696554 5.17570833333333 20 192 5 Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) Prkcz Pkcz RAF1 P04049 Homo sapiens (Human) 5.05175604535465 5.20217553516551 167 228 7.18562874251497 RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) RAF1 RAF YES P07947 Homo sapiens (Human) 5.03553250476568 5.25270195578231 98 150 7.14285714285714 Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) YES1 YES RSSA P08865 Homo sapiens (Human) 5.04382214691685 4.95 2 2 0 40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) (Small ribosomal subunit protein uS2) RPSA LAMBR LAMR1 LASR P25084 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 5.06245765508707 5.25458333333333 17 20 0 Transcriptional activator protein LasR lasR PA1430 LA P05455 Homo sapiens (Human) 3.5 5.00029761904762 1 2 0 Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B) SSB LDHB P07195 Homo sapiens (Human) 4.52980759038652 5.24419117647059 17 18 0 L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) LDHB LDHA P00338 Homo sapiens (Human) 4.44743872335621 5.20534183673469 49 82 2.04081632653061 L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) LDHA PIG19 LDLR P01130 Homo sapiens (Human) 6.22 5.14375 1 1 0 Low-density lipoprotein receptor (LDL receptor) LDLR ASGR1 P07306 Homo sapiens (Human) 2.4537179140055 5.4625 2 4 0 Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1) ASGR1 CLEC4H1 LEG1 P09382 Homo sapiens (Human) 3.76385011452491 5.265625 4 4 0 Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) LGALS1 LYAM1 P14151 Homo sapiens (Human) 4.96708136404204 5.57990740740741 9 9 22.2222222222222 L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L) SELL LNHR LYAM1 LYAM2 P16581 Homo sapiens (Human) 5.78313199565062 5.16798148148148 36 43 5.55555555555556 E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE ELAM1 LFA3 P19256 Homo sapiens (Human) 4.48891351052441 4.95 2 2 0 Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58) CD58 LFA3 LIPL P06858 Homo sapiens (Human) 5.85 4.996875 2 2 0 Lipoprotein lipase (LPL) (EC 3.1.1.34) LPL LIPD LIPP P16233 Homo sapiens (Human) 3.27 5.46428571428571 7 7 0 Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) PNLIP LOX15 P16050 Homo sapiens (Human) 4.6756661857367 5.33314265775883 973 1056 30.1130524152107 Arachidonate 15-lipoxygenase (15-LOX) (15-LOX-1) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate omega-6 lipoxygenase) ALOX15 LOG15 LOX1 P08170 Glycine max (Soybean) (Glycine hispida) 4.7495173947858 5.34087962962963 24 57 20.8333333333333 Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) (Lipoxygenase-1) (L-1) LOX1.1 LOX1 LOX5 P09917 Homo sapiens (Human) 5.44454455182187 5.22892113095238 182 320 7.14285714285714 Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 PTPRA P18433 Homo sapiens (Human) 4.52017435067441 5.32856770833333 16 19 0 Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 PTPRE P23469 Homo sapiens (Human) 3.83254545949954 5.622 5 5 0 Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE LSHR P16235 Rattus norvegicus (Rat) 6.97120893349069 4.95 20 54 0 Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LSH-R) Lhcgr LUCI P08659 Photinus pyralis (Common eastern firefly) (Lampyris pyralis) 5.02865637920336 5.220690616249 14469 16227 43.1197733084526 Luciferin 4-monooxygenase (Luciferase) (EC 1.13.12.7) LUCI P27652 Renilla reniformis (Sea pansy) 4.54714285714286 5.21616071428571 7 7 0 Coelenterazine h 2-monooxygenase (EC 1.13.12.5) (Renilla-luciferin 2-monooxygenase) (Renilla-type luciferase) MBL2 P11226 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 Mannose-binding protein C (MBP-C) (Collectin-1) (MBP1) (Mannan-binding protein) (Mannose-binding lectin) MBL2 COLEC1 MBL LEG3 P16110 Mus musculus (Mouse) 2.56992494444806 5.8625 1 1 0 Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (L-34 galactoside-binding lectin) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) Lgals3 IKBA P25963 Homo sapiens (Human) 5.17973941727038 5.095 5 11 0 NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) NFKBIA IKBA MAD3 NFKBI MAL62 P07265 Saccharomyces cerevisiae (Baker's yeast) 3.68627176956421 5.56375 6 8 0 Alpha-glucosidase MAL62 (EC 3.2.1.20) (Maltase) MAL62 MAL6S MRC1 P22897 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 CMA1 P23946 Homo sapiens (Human) 6.33440710257599 5.34106666666667 25 25 0 Chymase (EC 3.4.21.39) (Alpha-chymase) (Mast cell protease I) CMA1 CYH CYM CCL2 P13500 Homo sapiens (Human) 8.17 5.3875 1 1 0 C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2) CCL2 MCP1 SCYA2 MCR P08235 Homo sapiens (Human) 6.11851452337187 5.36581653681611 53 58 0 Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) NR3C2 MCR MLR MCR P22199 Rattus norvegicus (Rat) 2.87552939558478 5.33125 4 5 0 Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) Nr3c2 Mlr MDH P10584 Thermus thermophilus 5.075 5.225 1 2 0 Malate dehydrogenase (EC 1.1.1.37) mdh DPEP1 P22412 Sus scrofa (Pig) 5.66145891109635 5.41605555555556 30 30 0 Dipeptidase 1 (EC 3.4.13.19) (Microsomal dipeptidase) (Renal dipeptidase) DPEP1 RDP MDR1B P06795 Mus musculus (Mouse) 3.926 5.41 5 5 0 Multidrug resistance protein 1B (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1B) (P-glycoprotein 1) (CD antigen CD243) Abcb1b Abcb1 Mdr1 Mdr1b Pgy1 Pgy1-1 METK2 P18298 Rattus norvegicus (Rat) 4.06825642783668 4.86749999999999 1 3 0 S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) Mat2a Ams2 METK1 P13444 Rattus norvegicus (Rat) 4.11286040421285 4.86749999999999 2 4 0 S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) Mat1a Ams1 MGMT P16455 Homo sapiens (Human) 5.1773727814511 5.18140151515151 33 60 0 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) MGMT ERM P21236 Streptococcus pneumoniae 4.4 5.35 1 2 0 rRNA adenine N-6-methyltransferase (EC 2.1.1.184) (ErmAM) (Macrolide-lincosamide-streptogramin B resistance protein) erm MYB P01103 Gallus gallus (Chicken) 4.64571968632008 5.03125 2 4 0 Transcriptional activator Myb (Proto-oncogene c-Myb) MYB MYC P01106 Homo sapiens (Human) 4.58564445512543 4.93125 2 6 50 Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) MYC BHLHE39 NTCP P26435 Rattus norvegicus (Rat) 5.16749108729376 5.2125 1 1 0 Sodium/bile acid cotransporter (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (Solute carrier family 10 member 1) Slc10a1 Ntcp SC5A1 P13866 Homo sapiens (Human) 5.85751834664425 5.35454581376375 85 107 1.17647058823529 Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1) SLC5A1 NAGT SGLT1 SL9A1 P19634 Homo sapiens (Human) 5.94070033291381 5.14775 45 48 0 Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) SLC9A1 APNH1 NHE1 SL9A1 P23791 Oryctolagus cuniculus (Rabbit) 7.46 5.035 8 24 0 Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) SLC9A1 NHE1 SL9A3 P26432 Oryctolagus cuniculus (Rabbit) 7.39666666666667 5.06965277777778 9 27 0 Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3) SLC9A3 NHE3 NANH P10481 Clostridium perfringens 5.00101160735271 5.1875 2 2 50 Sialidase (EC 3.2.1.18) (Neuraminidase) nanH NCK1 P16333 Homo sapiens (Human) 3.93695437047216 5.40625 2 2 0 Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha) NCK1 NCK NEP P19621 Sus scrofa (Pig) 6.37 7.15 1 1 0 Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) (Fragment) MME NEP P08049 Oryctolagus cuniculus (Rabbit) 7.54227941176471 5.7321875 68 70 0 Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME NEP P07861 Rattus norvegicus (Rat) 7.02824370466637 5.51491319444444 72 78 1.38888888888889 Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Mme TNR16 P08138 Homo sapiens (Human) 5.43913063570619 5.11826388888889 3 3 0 Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271) NGFR TNFRSF16 NK1R P14600 Rattus norvegicus (Rat) 4.72265272151196 4.95799701789264 503 511 0 Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) Tacr1 Tac1r NK2R P16610 Rattus norvegicus (Rat) 6.20956075283007 4.9448275862069 29 31 0 Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) Tacr2 Tac2r NK3R P16177 Rattus norvegicus (Rat) 5.69964285714286 4.95 28 28 0 Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) Tacr3 Tac3r NTR1 P20789 Rattus norvegicus (Rat) 2 5.25 2 4 0 Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH) Ntsr1 Ntsr SC6A3 P23977 Rattus norvegicus (Rat) 6.3534069335949 5.23064174139248 156 236 1.28205128205128 Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) Slc6a3 SC6A2 P23975 Homo sapiens (Human) 5.4072423793367 5.21663456189132 359 512 7.24233983286908 Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) SLC6A2 NAT1 NET1 SLC6A5 NU1M P03887 Bos taurus (Bovine) 5.087 5.2673455006504 5 6 0 NADH-ubiquinone oxidoreductase chain 1 (EC 1.6.5.3) (NADH dehydrogenase subunit 1) MT-ND1 MTND1 NADH1 ND1 NADE P08164 Bacillus subtilis (strain 168) 3.69897000433602 5.6125 1 1 0 NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) (General stress protein 38) (GSP38) (Spore outgrowth factor B) (Sporulation protein OutB) nadE outB BSU03130 OXDA P00371 Sus scrofa (Pig) 4.66666666666667 5.32083333333333 3 3 0 D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO CH60 P10809 Homo sapiens (Human) 5.06814835773434 5.0859375 1 2 0 60 kDa heat shock protein, mitochondrial (EC 3.6.4.9) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) HSPD1 HSP60 PA21B P00592 Sus scrofa (Pig) 4.95341919158653 5.599375 4 6 0 Phospholipase A2, major isoenzyme (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) PLA2G1B PA21B P04055 Rattus norvegicus (Rat) 4.30102999566398 5.125 2 2 0 Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) Pla2g1b PA2GA P14555 Homo sapiens (Human) 5.18316879342782 5.1327 25 34 0 Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A) PLA2G2A PLA2B PLA2L RASF-A PA2GA P14423 Rattus norvegicus (Rat) 7.0625 5.41249999999999 4 4 0 Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A) Pla2g2a PA2A2 P15445 Naja naja (Indian cobra) 3.87234881814947 5.35979166666667 4 4 0 Acidic phospholipase A2 2 (PLA22) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) PCSK6 P29122 Homo sapiens (Human) 7.76 4.87291666666667 6 6 0 Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) PCSK6 PACE4 PTAFR P21556 Cavia porcellus (Guinea pig) 6.87215172701881 5.39047043010753 31 39 0 Platelet-activating factor receptor (PAF-R) (PAFr) PTAFR PAI1 P05121 Homo sapiens (Human) 5.04365282126491 5.36973333333333 25 28 0 Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1) SERPINE1 PAI1 PLANH1 PDGFB P01127 Homo sapiens (Human) 6 5.95 1 1 0 Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin) PDGFB PDGF2 SIS PEPC P20142 Homo sapiens (Human) 7.525 5.3375 2 2 0 Gastricsin (EC 3.4.23.3) (Pepsinogen C) PGC PERF P14222 Homo sapiens (Human) 5.1823850343699 5.20930989583333 16 19 0 Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP) PRF1 PFP PERL P80025 Bos taurus (Bovine) 4.52009125487802 5.084765625 4 8 25 Lactoperoxidase (LPO) (EC 1.11.1.7) LPO PERM P05164 Homo sapiens (Human) 5.65708297428848 5.24866477272727 22 38 0 Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] MPO PETD P00166 Spinacia oleracea (Spinach) 5.42714285714286 5.21205357142857 7 9 0 Cytochrome b6-f complex subunit 4 (17 kDa polypeptide) petD PGDH P15428 Homo sapiens (Human) 4.68913386778552 5.372413885141 4823 4895 44.4536595479992 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1) HPGD PGDH1 SDR36C1 PGFRB P09619 Homo sapiens (Human) 5.26386724999284 5.24816289121884 303 439 2.64026402640264 Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) PDGFRB PDGFR PDGFR1 PGFRB P05622 Mus musculus (Mouse) 5.10401450997353 5.32854116690318 110 139 0.909090909090909 Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) Pdgfrb Pdgfr Pdgfr1 PGFRA P16234 Homo sapiens (Human) 4.99106524645956 5.23892572378509 194 462 3.09278350515464 Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) PDGFRA PDGFR2 RHEPDGFRA PGFRA P20786 Rattus norvegicus (Rat) 5.81 5.00234375 4 10 0 Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a) Pdgfra PGH1 P22437 Mus musculus (Mouse) 5.07151453245199 5.07380952380952 28 39 0 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) Ptgs1 Cox-1 Cox1 PHLC P09598 Bacillus cereus 4.75333333333333 5.07083333333333 3 5 0 Phospholipase C (PLC) (EC 3.1.4.3) (Cereolysin A) (Phosphatidylcholine cholinephosphohydrolase) plc PLCG1 P19174 Homo sapiens (Human) 3.99365155560164 5.10953125 16 16 18.75 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1) PLCG1 PLC1 PLCG1 P10686 Rattus norvegicus (Rat) 2 4.93333333333333 1 1 100 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1) Plcg1 PLCG2 P24135 Rattus norvegicus (Rat) 2 4.93333333333333 1 1 100 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) Plcg2 TSPO P16257 Rattus norvegicus (Rat) 6.84665097220417 5.21979055133178 34 60 0 Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) Tspo Bzrp Mbr PLF4 P02776 Homo sapiens (Human) 5.52 4.95 1 1 0 Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form (Endothelial cell growth inhibitor)] PF4 CXCL4 SCYB4 PLMN P00747 Homo sapiens (Human) 4.91381147246403 5.28048674685741 104 114 0.961538461538462 Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] PLG PNMT P10938 Bos taurus (Bovine) 4.40646576331932 5.40052083333333 32 53 0 Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) PNMT POL P03359 Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus) 5.68 5.12499999999998 2 2 0 Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] (Fragment) pol PPB1 P05187 Homo sapiens (Human) 3.95368769297477 5.20041346153846 13 14 0 Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1) ALPP PLAP PPBI P09923 Homo sapiens (Human) 4.11645923110277 5.26967948717949 26 28 26.9230769230769 Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) ALPI PPBI P24822 Mus musculus (Mouse) 4.55 5.23733333333333 10 10 0 Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) (Alkaline phosphatase 3) Iap Akp-3 Akp3 PARP1 P09874 Homo sapiens (Human) 6.66974223649116 5.25883848072931 294 394 1.02040816326531 Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT PPOL PARP1 P11103 Mus musculus (Mouse) 6.05097146947773 5.35239145658263 17 21 0 Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (msPARP) Parp1 Adprp Adprt Adprt1 PSA1 P25786 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-1 (EC 3.4.25.1) (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) PSMA1 HC2 NU PROS30 PSC2 PSA2 P25787 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-2 (EC 3.4.25.1) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) PSMA2 HC3 PSC3 PSB1 P20618 Homo sapiens (Human) 4.47683942978961 5.75527412280702 14 62 0 Proteasome subunit beta type-1 (EC 3.4.25.1) (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) PSMB1 PSC5 PSA3 P25788 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-3 (EC 3.4.25.1) (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) PSMA3 HC8 PSC8 PSA4 P25789 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) PSMA4 HC9 PSC9 PRGR P06186 Oryctolagus cuniculus (Rabbit) 5.65729610172174 5.06958333333333 2 2 0 Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) PGR NR3C3 PRIO P04273 Mesocricetus auratus (Golden hamster) 5.55533140750198 5.44541666666667 2 5 0 Major prion protein (PrP) (PrP27-30) (PrP33-35C) (CD antigen CD230) PRNP PRP PRIO P04925 Mus musculus (Mouse) 5.00150532096713 5.34324074074074 9 10 0 Major prion protein (PrP) (PrP27-30) (PrP33-35C) (CD antigen CD230) Prnp Prn-p Prp PRIO P23907 Ovis aries (Sheep) 5.18 4.90625 1 1 0 Major prion protein (PrP) (CD antigen CD230) PRNP PRP SIP KLK3 P07288 Homo sapiens (Human) 5.97005310113532 4.96666666666667 3 3 0 Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase) KLK3 APS PROC P04070 Homo sapiens (Human) 5.19190120159497 5.29967391304348 23 25 0 Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] PROC PPGB P16675 Mus musculus (Mouse) 5 5.375 1 1 0 Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] Ctsa Ppgb PSBA P07753 Chlamydomonas reinhardtii (Chlamydomonas smithii) 6.4625 4.965625 2 3 0 Photosystem II protein D1 (PSII D1 protein) (EC 1.10.3.9) (32 kDa thylakoid membrane protein) (Photosystem II Q(B) protein) psbA PTN1 P20417 Rattus norvegicus (Rat) 4.34343334763989 5.23875 2 2 0 Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Ptpn1 PTN6 P29350 Homo sapiens (Human) 3.66253365373527 5.31016964285714 35 41 0 Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) PTPN6 HCP PTP1C PTP1 P25044 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4 5.7 1 1 0 Tyrosine-protein phosphatase 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1) (PTPase 1) PTP1 YDL230W PUR2 P22102 Homo sapiens (Human) 5.11250960061644 4.8921875 4 11 0 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] GART PGFT PRGS PYRD P28272 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5 4.85 1 1 100 Dihydroorotate dehydrogenase (fumarate) (DHOD) (DHODase) (DHOdehase) (EC 1.3.98.1) (Dihydroorotate oxidase) URA1 YKL216W RASH P01112 Homo sapiens (Human) 5.46008704183733 5.225 3 3 0 GTPase HRas (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] HRAS HRAS1 RASK P01116 Homo sapiens (Human) 2 4.925 1 1 0 GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] KRAS KRAS2 RASK2 RB P06400 Homo sapiens (Human) 4.25 5.0125 2 5 50 Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110) RB1 RENI1 P06281 Mus musculus (Mouse) 5.91333333333333 4.92083333333333 3 3 0 Renin-1 (EC 3.4.23.15) (Angiotensinogenase) (Kidney renin) Ren1 Ren Ren-1 RBTN2 P25791 Homo sapiens (Human) 7.54 4.95 1 1 0 Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2) LMO2 RBTN2 RBTNL1 RHOM2 TTG2 RIR1 P23921 Homo sapiens (Human) 4.70685422469503 5.37222222222222 9 40 11.1111111111111 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) RRM1 RR1 RARA P11416 Mus musculus (Mouse) 4.24667233334139 6.99787874528034 1 1 0 Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) Rara Nr1b1 RXRA P19793 Homo sapiens (Human) 4.722620980128 5.27238127480518 67 100 23.8805970149254 Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha) RXRA NR2B1 S100B P04271 Homo sapiens (Human) 4.94833333333333 5.06541666666667 6 8 0 Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B) S100B S5A1 P18405 Homo sapiens (Human) 5.47027787016228 5.27321875 20 25 0 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) SRD5A1 SAHH P10760 Rattus norvegicus (Rat) 4.50579089573233 5.2375 2 3 0 Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) Ahcy SDHL P09367 Rattus norvegicus (Rat) 5 6.3 1 1 0 L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) Sds SIR2 P06700 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.54455926635079 5.30818865740741 12 21 0 NAD-dependent histone deacetylase SIR2 (EC 3.5.1.-) (Regulatory protein SIR2) (Silent information regulator 2) SIR2 MAR1 YDL042C D2714 SODC P00441 Homo sapiens (Human) 3.74549490344758 5.075 4 5 0 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) SOD1 SP0F P06628 Bacillus subtilis (strain 168) 3.80447826642846 5.18185763888889 4 12 0 Sporulation initiation phosphotransferase F (EC 2.7.-.-) (Stage 0 sporulation protein F) spo0F BSU37130 SHBG P04278 Homo sapiens (Human) 6.24497287494301 5.356015625 8 10 12.5 Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin) SHBG STS P08842 Homo sapiens (Human) 5.51562033778338 5.2789856880169 51 86 1.96078431372549 Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) STS ARSC1 T2E1 P00642 Escherichia coli 4.30102999566398 4.9 2 2 0 Type-2 restriction enzyme EcoRI (R.EcoRI) (EC 3.1.21.4) (Endonuclease EcoRI) (Type II restriction enzyme EcoRI) ecoRIR JUN P05412 Homo sapiens (Human) 4.90381208659482 5.28735435965128 143 172 11.1888111888112 Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) JUN TAT P04326 Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1) 5.31527525184283 5.26238636363636 11 12 0 Protein Tat (Transactivating regulatory protein) tat TBA1A P02550 Sus scrofa (Pig) 4.92479798058727 5.25458079268293 41 53 0 Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] TUBA1A TBB P02554 Sus scrofa (Pig) 4.30340145224098 5.35257575757576 11 30 0 Tubulin beta chain (Beta-tubulin) TF P13726 Homo sapiens (Human) 5.76969645079539 5.50292892156863 34 116 0 Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142) F3 TGFB1 P01137 Homo sapiens (Human) 4.224897731272 5.46631944444445 2 2 0 Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)] TGFB1 TGFB THA P10827 Homo sapiens (Human) 6.11934632585053 5.249375 30 45 0 Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) THRA EAR7 ERBA1 NR1A1 THRA1 THRA2 THIO P10599 Homo sapiens (Human) 5.54967192186827 5.47916666666667 1 1 0 Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) TXN TRDX TRX TRX1 THRB P18292 Rattus norvegicus (Rat) 6.5025 5.3375 4 4 0 Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 TNFA P01375 Homo sapiens (Human) 5.05129054718476 5.217001953125 64 80 9.375 Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] TNF TNFA TNFSF2 TNFA P06804 Mus musculus (Mouse) 4.49463605897181 5.05763888888889 6 13 16.6666666666667 Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] Tnf Tnfa Tnfsf2 TNR1A P19438 Homo sapiens (Human) 5.08162061927691 5.12208333333333 12 12 0 Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] TNFRSF1A TNFAR TNFR1 DUS1 P28563 Mus musculus (Mouse) 4.42068666377599 5.08888888888889 3 3 0 Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase 3CH134) (Protein-tyrosine phosphatase ERP) Dusp1 3ch134 Mkp1 Ptpn10 Ptpn16 TPH1 P09810 Rattus norvegicus (Rat) 4.80390839108315 6.275 1 1 0 Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) Tph1 Tph TRFR P21761 Mus musculus (Mouse) 5.18647489741774 5.14416666666667 6 12 0 Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) Trhr TRY1 P07477 Homo sapiens (Human) 5.70481865287924 5.39327709394034 236 477 0.423728813559322 Trypsin-1 (EC 3.4.21.4) (Beta-trypsin) (Cationic trypsinogen) (Serine protease 1) (Trypsin I) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2] PRSS1 TRP1 TRY1 TRYP1 TRY1 P00762 Rattus norvegicus (Rat) 6.565 5.425 2 2 0 Anionic trypsin-1 (EC 3.4.21.4) (Anionic trypsin I) (Pretrypsinogen I) (Serine protease 1) Prss1 Try1 TRY2 P07478 Homo sapiens (Human) 5.48142882423437 5.41261673850575 116 354 0.862068965517241 Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II) PRSS2 TRY2 TRYP2 TY3H P04177 Rattus norvegicus (Rat) 2 5.1125 1 1 0 Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) Th TYSY P07607 Mus musculus (Mouse) 5.95727256553015 5.58925833333333 25 25 0 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) Tyms TYTR P28593 Trypanosoma cruzi 4.3630930677066 5.22273130215108 32 42 3.125 Trypanothione reductase (TR) (EC 1.8.1.12) (N(1),N(8)-bis(glutathionyl)spermidine reductase) TPR UCHL1 P09936 Homo sapiens (Human) 2 4.95 1 1 100 Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (EC 6.-.-.-) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) UCHL1 QCR7 P14927 Homo sapiens (Human) 4.84764258533123 5.2275 5 7 0 Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UQCRB UQBP UD2B7 P16662 Homo sapiens (Human) 5.08169999154871 5.30267857142857 14 63 14.2857142857143 UDP-glucuronosyltransferase 2B7 (UDPGT 2B7) (EC 2.4.1.17) (3,4-catechol estrogen-specific UDPGT) (UDP-glucuronosyltransferase 2B9) (UDPGT 2B9) (UDPGTh-2) UGT2B7 UGTB2B9 UD11 P22309 Homo sapiens (Human) 4.2735058191584 5.38892857142857 7 13 28.5714285714286 UDP-glucuronosyltransferase 1-1 (UDPGT 1-1) (UGT1*1) (UGT1-01) (UGT1.1) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 1) (hUG-BR1) (UDP-glucuronosyltransferase 1-A) (UGT-1A) (UGT1A) (UDP-glucuronosyltransferase 1A1) UGT1A1 GNT1 UGT1 UD14 P22310 Homo sapiens (Human) 3.32550706330564 5.26387624842678 3 4 0 UDP-glucuronosyltransferase 1-4 (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D) (UDP-glucuronosyltransferase 1A4) UGT1A4 GNT1 UGT1 PRIM P10236 Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 4.98927362802054 5.55866666666667 5 7 0 DNA primase (EC 2.7.7.-) UL52 USP P20153 Drosophila melanogaster (Fruit fly) 3.00018364065731 5.38597222222222 6 14 0 Protein ultraspiracle (Chorion factor 1) (Nuclear receptor subfamily 2 group B member 4) (XR2C) usp Cf1 NR2B4 CG4380 VCAM1 P19320 Homo sapiens (Human) 5.92941476930728 5.08273148148148 27 31 0 Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) VCAM1 UNG P04303 Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) 3.75901239701917 5.4875 3 3 33.3333333333333 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG TS17 VACWR109 D4R VDR P11473 Homo sapiens (Human) 4.37074706782976 5.30826209759964 2774 3081 19.718817591925 Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) VDR NR1I1 VE1 P04014 Human papillomavirus type 11 4.75563667100269 5.09425925925926 9 9 0 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 VE6 P03126 Human papillomavirus type 16 2 5.0625 2 2 50 Protein E6 E6 VTDB P02774 Homo sapiens (Human) 3.70302934590748 4.82499999999999 4 4 0 Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf) GC VTDB P04276 Rattus norvegicus (Rat) 8.42365864979421 5.11999999999999 1 1 0 Vitamin D-binding protein (DBP) (VDB) (Gc-globulin) (Group-specific component) Gc Dbp WNT3A P27467 Mus musculus (Mouse) 4.82616375495496 5.27625992063492 42 45 19.047619047619 Protein Wnt-3a Wnt3a Wnt-3a G6PD P11411 Leuconostoc mesenteroides 4.60205999132796 5.54065840918946 33 33 0 Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.363) (Glucose-6-phosphate dehydrogenase (NAD(P)(+))) zwf GBRR1 P24046 Homo sapiens (Human) 5.13028976996455 5.33166666666666 3 5 0 Gamma-aminobutyric acid receptor subunit rho-1 (GABA(A) receptor subunit rho-1) (GABA(C) receptor) GABRR1 KS6B1 P23443 Homo sapiens (Human) 5.02937429766717 5.24677625464685 269 345 3.71747211895911 Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) RPS6KB1 STK14A ITAL P24063 Mus musculus (Mouse) 6.52432881167557 5.3 1 1 0 Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen 15) (Ly-15) (CD antigen CD11a) Itgal Lfa-1 Ly-15 ACM1 P08482 Rattus norvegicus (Rat) 5.74296328415248 5.33115882923335 259 1138 9.65250965250965 Muscarinic acetylcholine receptor M1 Chrm1 Chrm-1 ACM4 P08485 Rattus norvegicus (Rat) 6.21023705652662 5.31328566087643 120 1026 0.833333333333333 Muscarinic acetylcholine receptor M4 Chrm4 Chrm-4 C3TRK2 C3TRK2 Escherichia coli 3.24743798989883 5.13533333333333 5 12 0 Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) dnaK dnaK_1 dnaK_2 A4T40_03375 A5958_06230 A8C65_15055 A8M42_06005 A8M44_15235 A8M72_10185 A8M81_20455 A9R57_26550 A9X62_09220 AA102_14450 AC067_06865 ACN77_14715 ACN81_23495 ACU57_07555 ACU90_27335 AKG99_18015 AKN40_4227 AM266_16720 AM270_12455 AM375_24615 AMK83_22665 AML07_24015 AML35_20560 APT94_26995 APU18_05425 APZ14_00135 ARC77_19375 AU473_26775 AUQ13_08295 AUS26_14245 AW059_08980 AW106_03530 AWP75_12615 AZZ83_003819 B7C53_17060 BE932_23075 BE957_25140 BE963_13995 BHF46_08695 BHS80_24265 BHS81_26285 BHS87_24635 BIQ87_25220 BJJ90_22145 BK248_20605 BK292_12860 BK334_15840 BK373_08825 BK375_05445 BK383_13760 BK400_04420 BMT53_10300 BMT91_18490 BMT94_05790 BMT97_06705 BUE81_09465 BUE82_20810 BW690_00420 BWP17_03525 BXT93_08510 BZL31_17420 BZL33_11735 BZL69_04275 CA268_07420 CA270_20480 CA593_03690 CA947_11495 CCL28_21150 CDL37_17175 CDL44_03905 CDL57_11235 CES94_20805 CI718_07820 EC3234A_1c00470 ECONIH1_00070 ECs0014 EL79_3856 EL80_3802 ERS085365_02775 ERS085366_01212 ERS085374_01848 ERS085383_01337 ERS085386_00748 ERS085404_00870 ERS085406_00407 ERS085411_00211 ERS085416_04926 ERS139211_02336 ERS150876_00221 FORC28_5191 GJ11_00070 HMPREF3040_02440 HW42_03690 JD73_13895 MJ49_06965 MS6198_00130 PGD_03661 PU06_27390 RG28_04690 SK85_00013 SM09_00754 SY51_00070 UC41_15430 UN86_27485 UN91_11395 WM48_00075 WQ89_19905 WR15_20040 GRM5 P31424 Rattus norvegicus (Rat) 5.57293952138063 5.20288475177305 235 319 0.425531914893617 Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5 THER P00800 Bacillus thermoproteolyticus 5.46159244598094 5.41738715528455 29 37 0 Thermolysin (EC 3.4.24.27) (Thermostable neutral proteinase) npr CARP P11838 Cryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica) 5.24584446649179 4.96916666666667 3 3 0 Endothiapepsin (EC 3.4.23.22) (Aspartate protease) EAPA EPN-1 PYGM P00489 Oryctolagus cuniculus (Rabbit) 4.08317900831605 5.37972446236559 62 79 0 Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) PYGM ADA2A Q01338 Mus musculus (Mouse) 2.705 5.25458333333333 4 15 0 Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) Adra2a ADA2A P22909 Rattus norvegicus (Rat) 6.24725715339186 5.28561223865859 182 706 0 Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47) Adra2a ADA2C Q01337 Mus musculus (Mouse) 2.705 5.25458333333333 4 15 0 Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) Adra2c ADA2C P22086 Rattus norvegicus (Rat) 6.31664685264339 5.27593957402794 186 736 0 Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) Adra2c ATP4B P18598 Rattus norvegicus (Rat) 4.66656630252599 5.56125 2 8 0 Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain) Atp4b BCL2 P10415 Homo sapiens (Human) 6.33126633859999 5.04050264550264 63 75 0 Apoptosis regulator Bcl-2 BCL2 CCKAR P30551 Rattus norvegicus (Rat) 5.96642724947469 5.33088734567901 81 89 0 Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) Cckar CDK3 Q00526 Homo sapiens (Human) 4.82164791612654 5.27457465277778 76 250 13.1578947368421 Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) CDK3 CDKN3 CNGA1 Q00194 Bos taurus (Bovine) 5.045 4.9375 1 2 0 cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha) CNGA1 CNCG CNCG1 CCND2 P30279 Homo sapiens (Human) 6.20649500072267 5.28829282407407 18 72 5.55555555555556 G1/S-specific cyclin-D2 CCND2 PDE1B Q01066 Rattus norvegicus (Rat) 5.25692307692308 5.32201923076923 13 39 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) Pde1b Pde1b1 C11B2 P30099 Rattus norvegicus (Rat) 5.15 4.85 1 1 0 Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (CYPXIB2) (Cytochrome P450-Aldo-1) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) (EC 1.14.15.5) Cyp11b2 Cyp11b-2 PPIF P30405 Homo sapiens (Human) 8.26061624987212 4.95 3 3 0 Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) PPIF CYP3 DRD3 P30728 Mus musculus (Mouse) 4.34242268082221 4.85 1 5 0 D(3) dopamine receptor (Dopamine D3 receptor) Drd3 MK03 P27361 Homo sapiens (Human) 3.90510218637072 5.29730394638507 261 459 13.4099616858238 Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) MAPK3 ERK1 PRKM3 FABP5 Q01469 Homo sapiens (Human) 5.695 5.0753125 4 4 0 Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) FABP5 GBRA6 P30191 Rattus norvegicus (Rat) 6.19574155862667 5.16072860441268 309 5833 0.323624595469256 Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) Gabra6 Gabra-6 GASR P30553 Rattus norvegicus (Rat) 5.95857142857143 5.15241071428571 14 20 0 Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) Cckbr GRPR P30550 Homo sapiens (Human) 5.97 5.15972222222222 9 11 0 Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) GRPR GSTM2 P28161 Homo sapiens (Human) 6.74333333333333 5.1375 3 3 0 Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) GSTM2 GST4 CASP1 P29452 Mus musculus (Mouse) 6.85333333333333 5.55 3 3 0 Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] Casp1 Il1bc KAD2 P29410 Rattus norvegicus (Rat) 4.13469857389746 5.125 1 1 0 Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) Ak2 LUCI Q01158 Aquatica lateralis (Heike firefly) (Luciola lateralis) 4.20969823212649 4.93895833333333 3 4 0 Luciferin 4-monooxygenase (Luciferase) (EC 1.13.12.7) NK1R P30547 Cavia porcellus (Guinea pig) 5.70378606243616 4.97579475308642 18 21 0 Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 TAC1R NOS1 P29476 Rattus norvegicus (Rat) 3.38269315081767 5.31961260986447 156 255 16.6666666666667 Nitric oxide synthase, brain (EC 1.14.13.39) (BNOS) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) Nos1 Bnos NOS3 P29473 Bos taurus (Bovine) 4.37297082706161 5.41288363434959 36 45 0 Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII) NOS3 NOS3 P29474 Homo sapiens (Human) 4.9196638894746 5.37996128318584 113 142 0 Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII) NOS3 NOS2 P29477 Mus musculus (Mouse) 3.41702351657088 5.28428669372885 185 309 15.1351351351351 Nitric oxide synthase, inducible (EC 1.14.13.39) (Inducible NO synthase) (Inducible NOS) (iNOS) (Macrophage NOS) (MAC-NOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) Nos2 Inosl NK3R P30098 Cavia porcellus (Guinea pig) 2 5.63368055555556 1 1 0 Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 PE2R3 P30557 Mus musculus (Mouse) 6.203 5.49375 10 11 0 Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (Prostanoid EP3 receptor) Ptger3 Ptgerep3 PHHY P00438 Pseudomonas fluorescens 4 4.8625 1 1 0 p-hydroxybenzoate hydroxylase (PHBH) (PHBHase) (EC 1.14.13.2) (4-hydroxybenzoate 3-monooxygenase) pobA FNTA P29703 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.779375 5.3946875 8 22 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) RAM2 YKL019W SSR2 P30680 Rattus norvegicus (Rat) 6.615 5.11875 6 14 0 Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1) Sstr2 TRFR Q01717 Rattus norvegicus (Rat) 4.4 5.1675 5 8 0 Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) Trhr V2R P30518 Homo sapiens (Human) 6.08056617654927 5.24163888888889 45 57 0 Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) AVPR2 ADHR DIR DIR3 V2R VIPR1 P30083 Rattus norvegicus (Rat) 5.2725 5.274609375 4 16 0 Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) Vipr1 VGFR3 P35916 Homo sapiens (Human) 4.36371549194545 5.2057424590919 224 334 4.46428571428571 Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4) FLT4 VEGFR3 ROS1 P08922 Homo sapiens (Human) 4.39008546548553 5.28573506289308 159 207 4.40251572327044 Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ROS1 MCF3 ROS 5HT1F P30939 Homo sapiens (Human) 7.2735728913464 5.27373511904762 14 52 0 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) HTR1F HTR1EL 5HT1F P30940 Rattus norvegicus (Rat) 6.68516575828469 5.137476074313 19 134 0 5-hydroxytryptamine receptor 1F (5-HT-1F) (5-HT1F) (Serotonin receptor 1F) Htr1f 5ht1f 5HT2B P30994 Rattus norvegicus (Rat) 5.91148259961207 5.28044728780509 108 406 1.85185185185185 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (5-HT-2F) (Serotonin receptor 2B) (Stomach fundus serotonin receptor) Htr2b Srl AMPD3 Q01432 Homo sapiens (Human) 6.48 5.298125 6 6 0 AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase) AMPD3 BXA1 P10845 Clostridium botulinum 4.75779246293339 5.187635 50 67 0 Botulinum neurotoxin type A (BoNT/A) (EC 3.4.24.69) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain; Botulinum neurotoxin A heavy chain] botA atx bna CBPA1 P15085 Homo sapiens (Human) 5.4625 5.2171875 10 11 0 Carboxypeptidase A1 (EC 3.4.17.1) CPA1 CPA GCYB1 Q02153 Homo sapiens (Human) 3.42697744585425 5.223125 2 10 0 Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) GUCY1B3 GUC1B3 GUCSB3 GUCY1B1 DCAM P17708 Rattus norvegicus (Rat) 6.11333333333333 5.17999999999999 3 3 0 S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] Amd1 EDNRA P26684 Rattus norvegicus (Rat) 6.33716710811 5.30277941176471 85 103 0 Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) Ednra EDNRB P21451 Rattus norvegicus (Rat) 6.16860156811733 4.91764705882353 34 48 0 Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) Ednrb FDFT Q02769 Rattus norvegicus (Rat) 5.40110066373551 5.42958333333334 45 61 0 Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) Fdft1 FIBB P02675 Homo sapiens (Human) 4.41488655733417 5.2084375 4 8 25 Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain] FGB FPR2 P25090 Homo sapiens (Human) 4.58548679199543 5.0759765625 16 40 6.25 N-formyl peptide receptor 2 (FMLP-related receptor I) (FMLP-R-I) (Formyl peptide receptor-like 1) (HM63) (Lipoxin A4 receptor) (LXA4 receptor) (RFP) FPR2 FPRH1 FPRL1 LXA4R GBRA5 P31644 Homo sapiens (Human) 6.86493613728781 5.17659771126761 142 1372 0.704225352112676 Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) GABRA5 GNRHR P30968 Homo sapiens (Human) 7.14095720717783 5.01598958333333 64 97 0 Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) GNRHR GRHR FKBP4 Q02790 Homo sapiens (Human) 4.39767125751983 5.39375 5 6 0 Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] FKBP4 FKBP52 HRH1 P31389 Cavia porcellus (Guinea pig) 5.82299615435156 5.26295174661989 73 99 0 Histamine H1 receptor (H1R) (HH1R) HRH1 HRH1 P31390 Rattus norvegicus (Rat) 6.4775 5.39979166666667 4 4 0 Histamine H1 receptor (H1R) (HH1R) Hrh1 JHEA P30809 Trichoplusia ni (Cabbage looper) 6.72 5.2875 1 2 0 Juvenile hormone esterase, isoform A (JH esterase) (JHE-A) (EC 3.1.1.59) (Fragments) JHEB P30810 Trichoplusia ni (Cabbage looper) 6.72 5.2875 1 2 0 Juvenile hormone esterase, isoform B (JH esterase) (JHE-B) (EC 3.1.1.59) (Fragments) KPCE Q02156 Homo sapiens (Human) 5.66856131707673 5.29491189849219 137 877 5.10948905109489 Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) PRKCE PKCE METK2 P31153 Homo sapiens (Human) 5 4.93107322877336 3 3 0 S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) MAT2A AMS2 MATA2 GRM3 P31422 Rattus norvegicus (Rat) 5.20225010370942 5.23859126984127 21 41 0 Metabotropic glutamate receptor 3 (mGluR3) Grm3 Gprc1c Mglur3 SC5A2 P31639 Homo sapiens (Human) 7.4354964879068 5.37834199233833 151 171 0 Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) SLC5A2 SGLT2 S6A13 P31649 Mus musculus (Mouse) 4.7428034357436 5.24790178571429 14 20 0 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gabt3 Gat-3 Gat2 Gat3 S6A13 P31646 Rattus norvegicus (Rat) 3.20597718523608 5.20624999999999 2 12 0 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 S6A11 P31647 Rattus norvegicus (Rat) 3.20597718523608 5.20624999999999 2 12 0 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gat-3 Gat-b S6A12 P31651 Mus musculus (Mouse) 4.21444292516349 5.3015625 8 15 0 Sodium- and chloride-dependent betaine transporter (Na(+)/Cl(-) betaine/GABA transporter) (Sodium- and chloride-dependent GABA transporter 2) (GAT-2) (Solute carrier family 6 member 12) Slc6a12 Gabt2 Gat-2 Gat2 SC6A4 P31652 Rattus norvegicus (Rat) 6.44134599404756 5.22297988558047 153 189 0.65359477124183 Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Slc6a4 PO5F1 Q01860 Homo sapiens (Human) 2.93333333333333 5.46041666666667 6 20 0 POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) POU5F1 OCT3 OCT4 OTF3 E2F1 Q01094 Homo sapiens (Human) 4.18181818181818 5.36159090909091 1 11 0 Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) E2F1 RBBP3 RIR2 P31350 Homo sapiens (Human) 4.84116880222553 5.28525 10 38 10 Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) RRM2 RR2 S5A2 P31213 Homo sapiens (Human) 6.76503389577073 5.01883928571428 14 16 0 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase) SRD5A2 S5A2 P31214 Rattus norvegicus (Rat) 6.60333333333333 5.32384259259259 9 18 0 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) Srd5a2 SSR1 P30872 Homo sapiens (Human) 6.73354463508411 4.99155405405407 185 215 0 Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2) SSTR1 SSR1 P30873 Mus musculus (Mouse) 8.25 4.95 1 5 0 Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2) Sstr1 Smstr1 SSR2 P30874 Homo sapiens (Human) 6.75253839940254 5.00135359116023 181 210 0 Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1) SSTR2 SSR2 P30875 Mus musculus (Mouse) 8.25 4.95 1 5 0 Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1) Sstr2 Smstr2 Sst2 SSR3 P30936 Rattus norvegicus (Rat) 8.36 4.95 2 10 0 Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28) Sstr3 SSR4 P30937 Rattus norvegicus (Rat) 8.36 4.95 2 10 0 Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 TYRO P14679 Homo sapiens (Human) 4.71058709790132 5.30652777777778 18 19 5.55555555555556 Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) TYR END4 P0A6C1 Escherichia coli (strain K12) 4.40203081249361 5.45777116678035 60 61 35 Endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) nfo b2159 JW2146 FADH P46154 Pseudomonas putida (Arthrobacter siderocapsulatus) 6.39333333333333 5.44777777777778 9 9 11.1111111111111 Glutathione-independent formaldehyde dehydrogenase (FALDH) (FDH) (EC 1.2.1.46) (Formaldehyde dismutase) (EC 1.2.98.1) fdhA ACM4 P32211 Mus musculus (Mouse) 3.81967245880756 5.4515625 4 25 0 Muscarinic acetylcholine receptor M4 (Mm4 mAChR) Chrm4 Chrm-4 CXCR5 P32302 Homo sapiens (Human) 2.23902987745594 5.5358630952381 7 7 14.2857142857143 C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185) CXCR5 BLR1 MDR15 BRS3 P32247 Homo sapiens (Human) 6.69441111592891 5.075 9 10 0 Bombesin receptor subtype-3 (BRS-3) BRS3 CCKAR P32238 Homo sapiens (Human) 3.87115781510702 5.23664096789898 127 233 21.259842519685 Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR CCKRA CCR1 P32246 Homo sapiens (Human) 6.03590461150295 5.18228649237029 45 59 0 C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) CCR1 CMKBR1 CMKR1 SCYAR1 CLAT P32738 Rattus norvegicus (Rat) 2 4.975 3 3 0 Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) Chat CALCR P32214 Rattus norvegicus (Rat) 6.76 4.95 1 1 0 Calcitonin receptor (CT-R) (C1A/C1B) Calcr ADCY6 Q03343 Rattus norvegicus (Rat) 3.83 4.90416666666667 3 24 0 Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (ACVI) (Adenylyl cyclase 6) (AC6) (Ca(2+)-inhibitable adenylyl cyclase) Adcy6 AK1C1 Q04828 Homo sapiens (Human) 4.52810149244082 5.26626022919377 40 44 0 Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) AKR1C1 DDH DDH1 GASR P32239 Homo sapiens (Human) 6.38529680819592 5.16354254626365 103 141 0 Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) CCKBR CCKRB GCN5 Q03330 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 2 6.875 1 1 0 Histone acetyltransferase GCN5 (EC 2.3.1.48) GCN5 ADA4 SWI9 YGR252W GLP1R P32301 Rattus norvegicus (Rat) 4.69361994557048 4.8375 1 3 0 Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) Glp1r Glpr HPPD P32754 Homo sapiens (Human) 6.82384615384615 5.41557692307692 13 13 0 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) HPD PPD MC3R P33033 Mus musculus (Mouse) 6.00303997187783 4.94517045454545 44 48 0 Melanocortin receptor 3 (MC3-R) Mc3r MTSI P15840 Spiroplasma monobiae (strain ATCC 33825 / MQ-1) 3.92828985669991 5.063375 5 5 0 CPG DNA methylase (EC 2.1.1.37) (Cytosine-specific methyltransferase SssI) (M.SssI) sssIM mssSI OPRD P32300 Mus musculus (Mouse) 6.97778780917382 5.09163103684341 103 134 0 Delta-type opioid receptor (D-OR-1) (DOR-1) (K56) (MSL-2) Oprd1 PK3CA P32871 Bos taurus (Bovine) 7.635 5.359375 2 3 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) PIK3CA PE2R4 P32240 Mus musculus (Mouse) 7.16875 5.5515625 8 13 0 Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 FNTA Q04631 Rattus norvegicus (Rat) 6.56052462784447 5.14103070175439 38 76 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Fnta PSB9 P28065 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein) PSMB9 LMP2 PSMB6i RING12 PTH1R Q03431 Homo sapiens (Human) 4.54463879256291 5.28878853530839 5753 11530 28.9588041022075 Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 SSR3 P32745 Homo sapiens (Human) 6.36097424393659 5.01134236453203 203 247 0 Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28) SSTR3 TF65 Q04207 Mus musculus (Mouse) 3.5 4.9 2 2 50 Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) Rela Nfkb3 TREA P32358 Bombyx mori (Silk moth) 6.13978128124551 5.0375 1 3 0 Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) VIPR1 P32241 Homo sapiens (Human) 2.02656827909819 5.26922438861261 77 304 35.0649350649351 Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1) VIPR1 DDR2 Q16832 Homo sapiens (Human) 4.91625793588325 5.23260546875 80 128 11.25 Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) DDR2 NTRKR3 TKT TYRO10 NTRK3 Q16288 Homo sapiens (Human) 3.60334720855658 5.29469655265811 159 190 0.628930817610063 NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) NTRK3 TRKC CDR1 P43071 Candida albicans (Yeast) 5.59780759792124 5.05 2 2 50 Multidrug resistance protein CDR1 CDR1 GRM7 P35400 Rattus norvegicus (Rat) 3.34917902140589 5.37647569444445 12 21 0 Metabotropic glutamate receptor 7 (mGluR7) Grm7 Gprc1g Mglur7 SKN7 P38889 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.51663890555576 5.19596088435374 49 49 42.8571428571429 Transcription factor SKN7 (Peroxide sensitivity protein 9) SKN7 BRY1 POS9 YHR206W ADML P35318 Homo sapiens (Human) 5.93962179782547 5.13875 2 2 50 ADM [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] ADM AM AGTR1 P34976 Oryctolagus cuniculus (Rabbit) 7.76985658478442 5.35150462962963 27 30 0 Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 ADRB3 P13945 Homo sapiens (Human) 5.19701026748827 5.28134470288548 251 535 11.1553784860558 Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor) ADRB3 ADRB3R B3AR BGAL P29853 Aspergillus niger 5.00695437047216 5.43125 2 2 0 Beta-galactosidase (EC 3.2.1.23) (Lactase-N) (Lactase) (Tilactase) lacA BMP4 P21275 Mus musculus (Mouse) 4.626 5.13375 5 5 0 Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B) Bmp4 Bmp-4 Dvr-4 SIAT6 Q02734 Rattus norvegicus (Rat) 5.85 4.85 1 1 100 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6) [Cleaved into: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase soluble form] St3gal3 Siat6 CAH5A P35218 Homo sapiens (Human) 6.17170428796567 5.27361805555555 60 177 3.33333333333333 Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA) CA5A CA5 MMP13 P33435 Mus musculus (Mouse) 7.906 4.92875 5 5 0 Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) Mmp13 CRFR1 P34998 Homo sapiens (Human) 6.88271420640523 5.14576325575012 140 308 0 Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) CRHR1 CRFR CRFR1 CRHR GCYA2 P33402 Homo sapiens (Human) 4.04575749056067 5.64 1 4 0 Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) GUCY1A2 GUC1A2 GUCSA2 DACA Q05523 Geobacillus stearothermophilus (Bacillus stearothermophilus) 2 5.21250000000001 2 2 0 D-alanyl-D-alanine carboxypeptidase DacA (CPase) (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 5) (PBP-5) dacA ECR P34021 Drosophila melanogaster (Fruit fly) 5.7425 6.1875 4 4 0 Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 CG1765 GBRA3 P34903 Homo sapiens (Human) 6.40227299643113 5.195609375 120 1343 0.833333333333333 Gamma-aminobutyric acid receptor subunit alpha-3 (GABA(A) receptor subunit alpha-3) GABRA3 GNRHR P30969 Rattus norvegicus (Rat) 8.13193606938196 4.94976265822786 158 162 0 Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) Gnrhr GRK5 P34947 Homo sapiens (Human) 4.16249844076736 5.18263566347072 92 107 7.60869565217391 G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 HSF1 Q00613 Homo sapiens (Human) 2.264 5.39409375 5 10 0 Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) HSF1 HSTF1 INHBA Q04998 Mus musculus (Mouse) 4 5.378125 2 2 0 Inhibin beta A chain (Activin beta-A chain) Inhba ACVR1 Q04771 Homo sapiens (Human) 4.46288911509152 5.26588056167899 79 84 1.26582278481013 Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) ACVR1 ACVRLK2 KPCG P05129 Homo sapiens (Human) 3.99579669996551 5.2568178936447 235 979 1.70212765957447 Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) PRKCG PKCG LIPL Q06000 Rattus norvegicus (Rat) 4.30102999566398 5.925 1 1 0 Lipoprotein lipase (LPL) (EC 3.1.1.34) Lpl LUXR P12746 Aliivibrio fischeri (Vibrio fischeri) 4.42252381290788 5.20828431372549 17 33 0 Transcriptional activator protein LuxR luxR LUXS P35327 Vibrio fischeri (strain ATCC 700601 / ES114) 6.1055086610514 5.20541666666667 7 9 0 Transcriptional activator protein LuxR luxR VF_A0925 MPI P34949 Homo sapiens (Human) 4.48511903334006 5.33436065197429 121 158 25.6198347107438 Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) MPI PMI1 NCAP P33469 Human coronavirus OC43 (HCoV-OC43) 4.52287874528034 5.0625 1 2 0 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N) N 7a OPRD P33533 Rattus norvegicus (Rat) 6.75065454283036 5.34903126992171 94 186 0 Delta-type opioid receptor (D-OR-1) (DOR-1) (Opioid receptor A) Oprd1 Ror-a OPRK P33534 Mus musculus (Mouse) 6.56883758175374 5.22830929487179 14 47 0 Kappa-type opioid receptor (K-OR-1) (KOR-1) (MSL-1) Oprk1 OPRK P34975 Rattus norvegicus (Rat) 6.99644743067864 5.02980176732178 60 169 0 Kappa-type opioid receptor (K-OR-1) (KOR-1) Oprk1 Ror-d OPRM P33535 Rattus norvegicus (Rat) 6.96366327266226 5.23714144537872 161 266 0 Mu-type opioid receptor (M-OR-1) (MOR-1) (Opioid receptor B) Oprm1 Ror-b TA2R P34978 Rattus norvegicus (Rat) 7.39321274613441 5.63770833333334 4 4 0 Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) (TXR2) Tbxa2r UPAR Q03405 Homo sapiens (Human) 5.32285714285714 5.57053571428572 7 7 0 Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) PLAUR MO3 UPAR UREA P07374 Canavalia ensiformis (Jack bean) (Dolichos ensiformis) 4.6427834677313 5.14801666666667 25 38 4 Urease (EC 3.5.1.5) (Urea amidohydrolase) V2R Q00788 Rattus norvegicus (Rat) 6.044375 5.203125 16 26 0 Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) Avpr2 POL P03367 Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) 5.06 5.385 3 3 0 Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pol THRB P00734 Homo sapiens (Human) 5.82672340683073 5.30385560190032 669 757 5.38116591928251 Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 MERTK Q12866 Homo sapiens (Human) 4.85605385206163 5.26133154258779 94 160 9.57446808510638 Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) MERTK MER 5HT2A P28223 Homo sapiens (Human) 5.35717096403902 5.28462632472133 318 516 8.80503144654088 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) HTR2A HTR2 5HT5A P35364 Rattus norvegicus (Rat) 6.49 5.27464645754672 6 84 0 5-hydroxytryptamine receptor 5A (5-HT-5A) (5-HT5A) (REC17) (Serotonin receptor 5A) Htr5a 5ht5a 5HT5B P35365 Rattus norvegicus (Rat) 6.58714285714286 5.3532683921829 7 86 0 5-hydroxytryptamine receptor 5B (5-HT-5B) (5-HT5B) (MR22) (Serotonin receptor 5B) Htr5b 5ht5b ADA1B P15823 Rattus norvegicus (Rat) 5.23178782841224 5.30318298025207 283 890 9.18727915194346 Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) Adra1b ACHD Q07001 Homo sapiens (Human) 4.06918097161733 5.28746279761904 28 175 0 Acetylcholine receptor subunit delta CHRND ACHRD AGTR2 P35351 Rattus norvegicus (Rat) 5.33261771174168 5.34581033473715 28 67 0 Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2) Agtr2 ADRB3 P26255 Rattus norvegicus (Rat) 5.69504284007872 5.2714806547619 28 58 0 Beta-3 adrenergic receptor (Beta-3 adrenoreceptor) (Beta-3 adrenoceptor) Adrb3 Adrb3r CBS P35520 Homo sapiens (Human) 3.89867072341717 5.44 3 3 0 Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) CBS DDIT3 P35638 Homo sapiens (Human) 5.07595500650403 5.22244791666667 4 4 0 DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) DDIT3 CHOP CHOP10 GADD153 PDE1A P14100 Bos taurus (Bovine) 4.46781855612573 5.39028273809524 14 27 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) PDE1A PDE1B Q01061 Bos taurus (Bovine) 3.93576210058464 5.42186011904762 14 26 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) PDE1B PDE1B1 CRFR1 P35347 Mus musculus (Mouse) 6.55427017660309 4.95 40 130 0 Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) Crhr1 Crhr CRFR1 P35353 Rattus norvegicus (Rat) 7.79912121146585 5.51688193243817 65 152 0 Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) Crhr1 Crhr DHB2 P37059 Homo sapiens (Human) 5.17712836936702 5.19725663716814 113 134 1.76991150442478 Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) HSD17B2 EDH17B2 SDR9C2 ENV P35961 Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) 4.24673913043478 5.15403079710145 23 29 0 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] env EDNRB P35463 Sus scrofa (Pig) 4.88340211563477 5.44688701923077 52 55 0 Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB FOLR1 P15328 Homo sapiens (Human) 6.245 5.18249999999999 4 9 0 Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18) FOLR1 FOLR GBRD P18506 Rattus norvegicus (Rat) 6.226007746773 5.15975476952344 315 6064 0.317460317460317 Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) Gabrd GDE P35574 Oryctolagus cuniculus (Rabbit) 6.41 5.4625 1 1 0 Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] AGL GHRHR Q02644 Rattus norvegicus (Rat) 6.2699020836427 4.97053571428571 14 14 0 Growth hormone-releasing hormone receptor (GHRH receptor) (Growth hormone-releasing factor receptor) (GRF receptor) (GRFR) Ghrhr Grfr HXK4 P35557 Homo sapiens (Human) 6.18976749909988 5.24433685341147 70 102 1.42857142857143 Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) GCK KCNJ2 P35561 Mus musculus (Mouse) 5.74 5.6875 1 1 0 Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2) Kcnj2 Irk1 ACV1B P36896 Homo sapiens (Human) 5.44079860940771 5.17125672043011 31 36 19.3548387096774 Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) ACVR1B ACVRLK4 ALK4 GRM6 P35349 Rattus norvegicus (Rat) 4.57477486178059 5.39366319444445 24 41 4.16666666666667 Metabotropic glutamate receptor 6 (mGluR6) Grm6 Gprc1f Mglur6 MP2K2 P36507 Homo sapiens (Human) 4.26782471684369 5.28126893914912 87 119 3.44827586206897 Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) MAP2K2 MEK2 MKK2 PRKMK2 NMDE2 Q00960 Rattus norvegicus (Rat) 5.31223963411512 5.37205160145289 474 4464 0.421940928270042 Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) Grin2b NMDE3 Q00961 Rattus norvegicus (Rat) 5.29642308618695 5.37272786542343 469 4417 0.426439232409382 Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) Grin2c NMDZ1 Q05586 Homo sapiens (Human) 5.837701659943 5.24599074074074 45 340 0 Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) GRIN1 NMDAR1 NDUV1 P25708 Bos taurus (Bovine) 8.94183913391879 5.57403846153846 13 26 0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit) NDUFV1 UQOR1 OPRX P35377 Mus musculus (Mouse) 6.90523236716025 4.95 37 63 0 Nociceptin receptor (K3 opiate receptor) (Kappa-type 3 opioid receptor) (KOR-3) (ORGC) (Orphanin FQ receptor) Oprl1 Oor Oprl OPRX P35370 Rattus norvegicus (Rat) 5.826875 4.95 4 10 0 Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) (ROR-C) (XOR1) Oprl1 Oor Oprl PPM1A P35813 Homo sapiens (Human) 4.5306744049018 5.1675 3 3 0 Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) PPM1A PPPM1A P2RY2 P35383 Mus musculus (Mouse) 3.97433371888453 5.19583333333333 3 5 0 P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (Purinergic receptor) P2ry2 P2ru1 PE2R1 P35375 Mus musculus (Mouse) 5.23333333333333 5.5375 9 9 0 Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) Ptger1 Ptgerep1 PGH2 Q05769 Mus musculus (Mouse) 5.32085934023786 5.12830985915493 71 90 4.22535211267606 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (Glucocorticoid-regulated inflammatory cyclooxygenase) (Gripghs) (Macrophage activation-associated marker protein P71/73) (PES-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) (TIS10 protein) Ptgs2 Cox-2 Cox2 Pghs-b Tis10 PGH2 P35355 Rattus norvegicus (Rat) 4.72333155058357 5.19265664567217 66 137 1.51515151515152 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) Ptgs2 Cox-2 Cox2 PPARD P35396 Mus musculus (Mouse) 5 5.2975 5 5 20 Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) Ppard Nr1c2 Pparb RAD51 Q06609 Homo sapiens (Human) 4.52353128608188 5.609375 4 4 25 DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) RAD51 RAD51A RECA TIE1 P35590 Homo sapiens (Human) 5.218 5.4605 10 13 10 Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE UD13 P35503 Homo sapiens (Human) 3.75773316926701 5.68071968632008 4 4 25 UDP-glucuronosyltransferase 1-3 (UDPGT 1-3) (UGT1*3) (UGT1-03) (UGT1.3) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-C) (UGT-1C) (UGT1C) (UDP-glucuronosyltransferase 1A3) UGT1A3 GNT1 UGT1 VGFR1 P35969 Mus musculus (Mouse) 5.28666666666667 5.39791666666667 9 9 0 Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT) Flt1 Emrk2 Flt Vegfr1 VGFR2 P35918 Mus musculus (Mouse) 6.28330492158002 5.42109375 16 16 0 Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) Kdr Flk-1 Flk1 XYNB P36906 Thermoanaerobacterium saccharolyticum 5.12 5.0625 1 1 0 Beta-xylosidase (EC 3.2.1.37) (1,4-beta-D-xylan xylohydrolase) (Xylan 1,4-beta-xylosidase) xynB KPCT Q04759 Homo sapiens (Human) 5.23995865051323 5.2901080497533 263 1029 4.18250950570342 Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) PRKCQ PRKCT POL P03366 Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) 3.93930215964639 5.41249999999999 1 1 0 Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pol ACES P37136 Rattus norvegicus (Rat) 5.17217664317062 5.2129712043178 73 85 0 Acetylcholinesterase (AChE) (EC 3.1.1.7) Ache ALDR P80276 Sus scrofa (Pig) 4.7249777392202 5.48392361111111 12 12 0 Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) AKR1B1 ALR2 QOR Q08257 Homo sapiens (Human) 5 5.25 1 1 0 Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ DPOLB P06766 Rattus norvegicus (Rat) 4.4677940008672 5.55833333333333 5 7 0 DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) Polb FDFT P37268 Homo sapiens (Human) 6.33333333333333 5.14495706928712 15 15 0 Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) FDFT1 PF2R P37289 Bos taurus (Bovine) 3.92081875395238 5.1775 1 1 0 Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor) PTGFR PYGL P09811 Rattus norvegicus (Rat) 4.82302382925553 5.49375 2 3 0 Glycogen phosphorylase, liver form (EC 2.4.1.1) Pygl Lgp PPAC P11064 Bos taurus (Bovine) 3.48605531090274 5.31381729247967 4 4 0 Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) ACP1 PPARA P37230 Rattus norvegicus (Rat) 4 4.925 2 2 0 Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) Ppara Nr1c1 Ppar SCNNA P37088 Homo sapiens (Human) 4.2 4.8375 2 4 100 Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) SCNN1A SCNN1 SYUA P37840 Homo sapiens (Human) 4.88507113886175 5.28482255567061 1304 1313 24.9233128834356 Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) SNCA NACP PARK1 THB P10828 Homo sapiens (Human) 5.3154890557447 5.26365708312154 632 791 22.626582278481 Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta) THRB ERBA2 NR1A2 THR1 VANX Q06241 Enterococcus faecium (Streptococcus faecium) 5.82 4.82499999999999 1 1 0 D-alanyl-D-alanine dipeptidase (D-Ala-D-Ala dipeptidase) (EC 3.4.13.22) (Vancomycin B-type resistance protein VanX) vanX AAPK2 Q09137 Rattus norvegicus (Rat) 4.78479844369089 5.41208333333333 5 12 0 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Prkaa2 Ampk Ampk2 CAH P40881 Methanosarcina thermophila 6.77 5.44583333333333 1 2 0 Carbonic anhydrase (EC 4.2.1.1) ADCY8 P40145 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY8 ADCY8 P40146 Rattus norvegicus (Rat) 3.83 4.90416666666667 3 24 0 Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) Adcy8 PPID Q08752 Homo sapiens (Human) 7.46 4.95 1 2 0 Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) PPID CYP40 CYPD DAC P39045 Actinomadura sp. (strain R39) 6.38021124171161 4.8375 1 1 0 D-alanyl-D-alanine carboxypeptidase (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein) (PBP) dac DRTS Q07422 Toxoplasma gondii 6.2755146569495 5.35435016669494 115 238 0 Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] DYHC1 P38650 Rattus norvegicus (Rat) 4.30102999566398 5.055625 4 4 0 Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C) Dync1h1 Dhc1 Dnch1 Dnchc1 Dnec1 Dyhc Map1c ENPL P41148 Canis lupus familiaris (Dog) (Canis familiaris) 6.28 4.8375 1 1 0 Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) HSP90B1 GRP94 TRA1 FEN1 P39748 Homo sapiens (Human) 4.43029362061786 5.30670655354865 1321 1443 19.9848599545799 Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) FEN1 RAD2 CSF3R Q99062 Homo sapiens (Human) 4.33 4.8375 1 1 0 Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114) CSF3R GCSFR CSK P41240 Homo sapiens (Human) 4.69419834590705 5.23020071138211 82 118 6.09756097560976 Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL) CSK KPYR P12928 Rattus norvegicus (Rat) 2 5.09375 1 1 0 Pyruvate kinase PKLR (EC 2.7.1.40) (L-PK) (Pyruvate kinase isozymes L/R) Pklr LOX5 P12527 Rattus norvegicus (Rat) 5.70092828005958 5.16914329268293 205 254 0.975609756097561 Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) Alox5 MC5R P33032 Homo sapiens (Human) 3.73865308168253 5.15964840335935 125 227 21.6 Melanocortin receptor 5 (MC5-R) (MC-2) MC5R MC5R P41149 Mus musculus (Mouse) 5.87166666666667 4.95105324074074 54 56 3.7037037037037 Melanocortin receptor 5 (MC5-R) Mc5r MLTB P41052 Escherichia coli (strain K12) 3.72353819582676 5.375 1 1 0 Membrane-bound lytic murein transglycosylase B (EC 4.2.2.n1) (35 kDa soluble lytic transglycosylase) (Murein hydrolase B) (Slt35) mltB b2701 JW2671 PEPT1 P08176 Dermatophagoides pteronyssinus (European house dust mite) 6.99625 5.1296875 4 5 0 Peptidase 1 (EC 3.4.22.65) (Allergen Der p I) (Major mite fecal allergen Der p 1) (allergen Der p 1) DERP1 OPRK P41144 Cavia porcellus (Guinea pig) 7.37859676739931 5.18343573446328 177 213 0 Kappa-type opioid receptor (K-OR-1) (KOR-1) OPRK1 OPRX P41146 Homo sapiens (Human) 6.69139025687334 5.26718091055405 54 103 0 Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) OPRL1 OOR ORL1 PA2G5 P39877 Homo sapiens (Human) 4.94040653414451 5.17395833333333 3 3 0 Calcium-dependent phospholipase A2 (EC 3.1.1.4) (Group V phospholipase A2) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5) PLA2G5 PPAL P40347 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.72584215073632 5.675 1 1 0 Low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (PTPase) LTP1 YPR073C YP9499.28C PSB10 P40306 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i) PSMB10 LMP10 MECL1 SSR5 P30938 Rattus norvegicus (Rat) 8.36 4.95 2 10 0 Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) Sstr5 TPOR P40238 Homo sapiens (Human) 5.59461645489046 5.18601190476191 14 16 0 Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110) MPL TPOR LYS12 P40495 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 2 4.9625 1 1 0 Homoisocitrate dehydrogenase, mitochondrial (HIcDH) (EC 1.1.1.87) LYS12 LYS10 LYS11 YIL094C YI9910.02C PAK2 Q13177 Homo sapiens (Human) 4.55457237066132 5.22806924882629 71 106 12.6760563380282 Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] PAK2 SAV P22629 Streptomyces avidinii 5 6.7475 1 1 0 Streptavidin CELA1 P00772 Sus scrofa (Pig) 4.3714974981914 5.0940625 10 19 0 Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) CELA1 ELA1 SRC P12931 Homo sapiens (Human) 4.92060683431251 5.24598265816272 548 643 1.09489051094891 Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC SRC1 SRC P00523 Gallus gallus (Chicken) 5.14450408608389 5.16870833333333 18 19 0 Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC STE24 P47154 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.10777777777778 5.75833333333333 9 9 66.6666666666667 CAAX prenyl protease 1 (EC 3.4.24.84) (A-factor-converting enzyme) (Prenyl protein-specific endoprotease 1) (PPSEP 1) STE24 AFC1 YJR117W J2032 ELAV1 Q15717 Homo sapiens (Human) 4.57333344749883 5.86875 2 2 0 ELAV-like protein 1 (Hu-antigen R) (HuR) ELAVL1 HUR RENI P00797 Homo sapiens (Human) 7.07085621387932 5.2386953828829 370 537 0 Renin (EC 3.4.23.15) (Angiotensinogenase) REN AMPL P00727 Bos taurus (Bovine) 4.15 5.484375 1 1 0 Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 5HT6R P31388 Rattus norvegicus (Rat) 6.49 5.27464645754672 6 84 0 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (ST-B17) (Serotonin receptor 6) Htr6 5HT3A P35563 Rattus norvegicus (Rat) 6.97704084828491 5.34246696790554 119 356 0 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) Htr3a 5ht3 Htr3 ADA1D P25100 Homo sapiens (Human) 4.80254459974932 5.25066051604689 195 362 13.3333333333333 Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) ADRA1D ADRA1A ADA1A P35348 Homo sapiens (Human) 6.68202404045306 5.25242170421829 161 295 0.62111801242236 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c) ADRA1A ADRA1C AA2AR P46616 Cavia porcellus (Guinea pig) 5.05321968632008 5.234375 4 4 0 Adenosine receptor A2a ADORA2A ABL2 P42684 Homo sapiens (Human) 5.18040390884081 5.24533653846154 104 192 9.61538461538462 Abelson tyrosine-protein kinase 2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) ABL2 ABLL ARG ACHA6 P43143 Rattus norvegicus (Rat) 6.84101546577447 5.20632335680751 71 953 1.40845070422535 Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 ALDR P07943 Rattus norvegicus (Rat) 3.94650168955305 5.24388487375302 219 317 11.4155251141553 Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) Akr1b1 Akr1b4 Aldr1 CAH7 P43166 Homo sapiens (Human) 6.47689046711685 5.23081751054852 79 197 7.59493670886076 Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII) CA7 CASR P41180 Homo sapiens (Human) 6.42562691294839 5.22252688172043 31 82 0 Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) CASR GPRC2A PCAR1 CATK P43236 Oryctolagus cuniculus (Rabbit) 7.48357591435522 5.02229166666667 8 8 0 Cathepsin K (EC 3.4.22.38) (Protein OC-2) CTSK CDK4 P11802 Homo sapiens (Human) 6.02434099555022 5.25532594838308 268 501 1.11940298507463 Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) CDK4 CHS1 P23316 Candida albicans (Yeast) 4.18725898352996 5.565625 4 8 0 Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) CHS1 CCR2 P41597 Homo sapiens (Human) 3.82500190152565 5.30715413870586 134 235 20.1492537313433 C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192) CCR2 CMKBR2 MATK P42679 Homo sapiens (Human) 2.75308641975309 5.27715277777778 81 82 0 Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) MATK CTK HYL PPIC P45877 Homo sapiens (Human) 6.93 4.95 1 1 0 Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) PPIC CYPC DAPE P44514 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 4.38 5.46666666666667 1 1 0 Succinyl-diaminopimelate desuccinylase (SDAP desuccinylase) (EC 3.5.1.18) (N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase) dapE HI_0102 DCK P43346 Mus musculus (Mouse) 6.16761318992918 5 1 2 0 Deoxycytidine kinase (dCK) (EC 2.7.1.74) Dck DHB3 P37058 Homo sapiens (Human) 5.97085462382548 5.21116898148148 18 21 5.55555555555556 Testosterone 17-beta-dehydrogenase 3 (EC 1.1.1.64) (17-beta-hydroxysteroid dehydrogenase type 3) (17-beta-HSD 3) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) HSD17B3 EDH17B3 SDR12C2 DYR P22906 Candida albicans (Yeast) 6.04766666666667 5.23079166666667 10 14 0 Dihydrofolate reductase (EC 1.5.1.3) DFR1 EAA1 P43003 Homo sapiens (Human) 4.01197461833422 5.39257440476191 35 52 0 Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) SLC1A3 EAAT1 GLAST GLAST1 MTOR P42346 Rattus norvegicus (Rat) 8.78666666666667 5.74583333333333 3 3 0 Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) Mtor Frap1 Raft1 FRK P42685 Homo sapiens (Human) 4.08731823219921 5.21233362268519 144 197 6.94444444444444 Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5) FRK PTK5 RAK G6PC P43428 Rattus norvegicus (Rat) 4.42436895968781 5.23375 4 5 0 Glucose-6-phosphatase (G-6-Pase) (G6Pase) (EC 3.1.3.9) G6pc G6pt GCR P06536 Rattus norvegicus (Rat) 4.4933361666707 4.89375 2 2 0 Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) Nr3c1 Grl GRIK1 P22756 Rattus norvegicus (Rat) 4.7172777241983 5.35767962598425 127 627 0.78740157480315 Glutamate receptor ionotropic, kainate 1 (GluK1) (Glutamate receptor 5) (GluR-5) (GluR5) Grik1 Glur5 CAK1 P43568 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.30102999566398 4.95 1 1 0 Serine/threonine-protein kinase CAK1 (EC 2.7.11.22) (CDK-activating kinase) CAK1 CIV1 YFL029C KPB2 P46019 Homo sapiens (Human) 6.44675833482469 5.26255208333333 4 20 0 Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) PHKA2 PHKLA PYK LKHA4 P19602 Cavia porcellus (Guinea pig) 5.53714285714286 5.16903678436581 7 8 0 Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H NR4A2 P43354 Homo sapiens (Human) 7.30299000144534 5.17604166666667 3 3 0 Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor) NR4A2 NOT NURR1 TINUR SO1A2 P46721 Homo sapiens (Human) 5.49701115191627 4.93541666666666 3 3 0 Solute carrier organic anion transporter family member 1A2 (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3) SLCO1A2 OATP OATP1 OATP1A2 SLC21A3 SO1A1 P46720 Rattus norvegicus (Rat) 4.73171668826759 5.58125 8 10 25 Solute carrier organic anion transporter family member 1A1 (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter 1) (Solute carrier family 21 member 1) Slco1a1 Oatp1 Oatp1a1 Slc21a1 OPRM P42866 Mus musculus (Mouse) 7.19285170592181 5.20230576923077 50 83 0 Mu-type opioid receptor (M-OR-1) (MOR-1) Oprm1 Mor Oprm PK3CB P42338 Homo sapiens (Human) 5.97879502069506 5.22991095772762 201 314 0.995024875621891 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) PIK3CB PIK3C1 PACR P41586 Homo sapiens (Human) 6.33983155593538 4.96625 10 26 0 Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) ADCYAP1R1 NAMPT P43490 Homo sapiens (Human) 6.17199845043264 5.25016145833333 40 50 0 Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) NAMPT PBEF PBEF1 PCP P42785 Homo sapiens (Human) 5.83430450906466 5.40638888888889 18 19 0 Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) PRCP PCP PE2R3 P43115 Homo sapiens (Human) 6.25055747444064 5.3278125 36 41 0 Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) PTGER3 PE2R4 P43114 Rattus norvegicus (Rat) 5.49485002168009 5.25416666666667 1 1 0 Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 S15A1 P46059 Homo sapiens (Human) 4.17800330363188 5.26513621794872 26 32 0 Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1) SLC15A1 PEPT1 PF2R P43088 Homo sapiens (Human) 6.29240807125256 5.271 5 5 0 Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor) PTGFR PF2R P43117 Mus musculus (Mouse) 3.974914167028 5.8125 2 13 0 Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor) Ptgfr PI2R P43119 Homo sapiens (Human) 5.54805926039108 5.47544871794872 26 27 0 Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) PTGIR PRIPR PLM2 P46925 Plasmodium falciparum 6.62042066939984 5.25106481481481 27 29 0 Plasmepsin-2 (EC 3.4.23.39) (Aspartic hemoglobinase II) (PFAPD) PTN9 P43378 Homo sapiens (Human) 4.43077249674799 5.490625 4 4 0 Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2) PTPN9 QOR P47199 Mus musculus (Mouse) 5.07708603226407 5.32288690476191 14 15 0 Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) Cryz RNT1 P00651 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) 4.62711918962363 5.8675 2 2 0 Guanyl-specific ribonuclease T1 (RNase T1) (EC 3.1.27.3) rntA AO090011000118 STAT1 P42225 Mus musculus (Mouse) 2 5.2625 3 4 0 Signal transducer and activator of transcription 1 Stat1 STAT6 P42226 Homo sapiens (Human) 5.66326835352326 5.43799242424242 22 44 31.8181818181818 Signal transducer and activator of transcription 6 (IL-4 Stat) STAT6 STA5A P42229 Homo sapiens (Human) 4 5.375 3 9 0 Signal transducer and activator of transcription 5A STAT5A STAT5 SYI1 P41972 Staphylococcus aureus 6.51666666666667 6.44249999999999 3 3 0 Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) ileS KGP1 Q13976 Homo sapiens (Human) 4.15045166164028 5.22600582437276 155 254 6.45161290322581 cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B MEP2 P41948 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.64 5.6875 1 1 0 Ammonium transporter MEP2 MEP2 AMT2 YNL142W N1207 N1820 C71B1 P49264 Thlaspi arvense (Field penny-cress) 4.71394958320545 5.553125 1 3 0 Cytochrome P450 71B1 (EC 1.14.-.-) (CYPLXXIB1) CYP71B1 CASR P48442 Rattus norvegicus (Rat) 4.40322365719681 5.125 2 4 0 Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR) Casr Gprc2a Pcar1 CNR1 P47746 Mus musculus (Mouse) 3.82634095784312 5.18125 2 2 50 Cannabinoid receptor 1 (CB-R) (CB1) (Brain-type cannabinoid receptor) Cnr1 CNR2 P47936 Mus musculus (Mouse) 6.24 5.09375 1 1 0 Cannabinoid receptor 2 (CB-2) (CB2) (mCB2) Cnr2 CDK8 P49336 Homo sapiens (Human) 5.14320987654321 5.23874719390091 81 87 3.7037037037037 Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) CDK8 CSF1 P07141 Mus musculus (Mouse) 8.33257574905607 5.57716666666667 5 6 0 Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] Csf1 Csfm GIPR P48546 Homo sapiens (Human) 5.86 5.375 1 1 0 Gastric inhibitory polypeptide receptor (GIP-R) (Glucose-dependent insulinotropic polypeptide receptor) GIPR GLR P47871 Homo sapiens (Human) 4.67296889978251 5.0599622757661 26 31 7.69230769230769 Glucagon receptor (GL-R) GCGR GLR P30082 Rattus norvegicus (Rat) 5.37489503256918 5.10357142857143 7 9 0 Glucagon receptor (GL-R) Gcgr GYRA P20831 Staphylococcus aureus 6.50029366975263 5.41194444444444 9 18 0 DNA gyrase subunit A (EC 5.99.1.3) gyrA HRH2 P47747 Cavia porcellus (Guinea pig) 5.0916690604312 5.25569943804078 31 36 0 Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 HPPD Q02110 Sus scrofa (Pig) 4.97812110966577 5.396875 3 5 0 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) HPD KC1E P49674 Homo sapiens (Human) 5.13764991718295 5.25454545454545 22 46 4.54545454545455 Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) CSNK1E MAOX P48163 Homo sapiens (Human) 5.5 5.2 1 1 100 NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) ME1 MTR1A P49285 Gallus gallus (Chicken) 6.5345652173913 5.06310688405797 23 81 0 Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) (CKA) MTR1B P49286 Homo sapiens (Human) 7.23365673123361 5.20029421119593 131 226 0 Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) MTNR1B MTR1C P49288 Gallus gallus (Chicken) 7.12165942028985 5.08724184782609 46 168 0 Melatonin receptor type 1C (Mel-1C-R) (Mel1c receptor) (CKB) MTR1C P49219 Xenopus laevis (African clawed frog) 6.951 5.11666666666667 5 6 0 Melatonin receptor type 1C (Mel-1C-R) (Mel1c (alpha) receptor) (Mel1c receptor) mtnr1c MK14 P47811 Mus musculus (Mouse) 7.04636363636364 5.2236553030303 11 11 0 Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Mapk14 Crk1 Csbp1 Csbp2 FNTA P49354 Homo sapiens (Human) 6.49265995283036 5.3269271636384 109 366 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA FNTB P49355 Bos taurus (Bovine) 7.14967140151944 5.50055357142857 35 74 0 Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB FNTB P49356 Homo sapiens (Human) 6.82539594100828 5.32713320909285 114 306 0 Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB RENI P08424 Rattus norvegicus (Rat) 7.22428571428571 4.95 7 7 0 Renin (EC 3.4.23.15) (Angiotensinogenase) Ren1 Ren RFA1 P27694 Homo sapiens (Human) 5.79448117494023 5.0375 17 17 0 Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] RPA1 REPA1 RPA70 RN5A Q05823 Homo sapiens (Human) 6.15166666666667 4.95 21 30 0 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) RNASEL RNS4 RXRB P28702 Homo sapiens (Human) 3.535 4.92604166666667 3 4 0 Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta) RXRB NR2B2 RXRG P48443 Homo sapiens (Human) 4.1275 4.9125 2 3 0 Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma) RXRG NR2B3 SUIS P23739 Rattus norvegicus (Rat) 5.10457403551972 5.10866666666667 15 27 6.66666666666667 Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)] Si T23O P48775 Homo sapiens (Human) 5.79857142857143 5.45345238095238 7 7 0 Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) TDO2 TDO NR2C2 P49116 Homo sapiens (Human) 5.75482523977329 5.125 2 2 0 Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 TAK1 TR4 LT P03070 Simian virus 40 (SV40) 4.72114584066104 5.33609990253412 171 194 22.2222222222222 Large T antigen (LT) (LT-AG) (EC 3.6.4.-) THAS P49430 Rattus norvegicus (Rat) 5.32666873563102 5.3537712191358 54 69 1.85185185185185 Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) Tbxas1 Cyp5 Cyp5a1 V1BR P47901 Homo sapiens (Human) 5.54233438975503 5.26607469512195 82 90 6.09756097560976 Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) AVPR1B AVPR3 VPR3 V1BR P48974 Rattus norvegicus (Rat) 5.04 5.21125 4 16 0 Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) Avpr1b CX3C1 P49238 Homo sapiens (Human) 6.65 4.9125 8 8 0 CX3C chemokine receptor 1 (C-X3-C CKR-1) (CX3CR1) (Beta chemokine receptor-like 1) (CMK-BRL-1) (CMK-BRL1) (Fractalkine receptor) (G-protein coupled receptor 13) (V28) CX3CR1 CMKBRL1 GPR13 WEE1 P30291 Homo sapiens (Human) 5.47405013171754 5.20219444444445 60 103 13.3333333333333 Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) WEE1 XDH P22985 Rattus norvegicus (Rat) 5.3475 4.97625 2 3 0 Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] Xdh AA1R P47745 Cavia porcellus (Guinea pig) 5.98530091805494 5.28024801587302 42 53 0 Adenosine receptor A1 ADORA1 ACE P47820 Rattus norvegicus (Rat) 6.89683623485589 5.49596226607247 67 69 0 Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] Ace Dcp1 ACHA4 P43681 Homo sapiens (Human) 5.10679301912107 5.24153546466003 100 400 1 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 NACRA4 ACHA7 P49582 Mus musculus (Mouse) 6.16333333333333 4.95416666666667 3 11 0 Neuronal acetylcholine receptor subunit alpha-7 Chrna7 Acra7 ALBU P02769 Bos taurus (Bovine) 3.67635971403615 5.35842361111111 30 41 10 Serum albumin (BSA) (allergen Bos d 6) ALB AMY1 P04745 Homo sapiens (Human) 3.80973677569007 5.01273148148148 9 12 11.1111111111111 Alpha-amylase 1 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary alpha-amylase) AMY1A AMY1; AMY1B AMY1; AMY1C AMY1 CP2E1 P05182 Rattus norvegicus (Rat) 3.72584215073632 5.25 1 1 0 Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6) Cyp2e1 Cyp2e Cyp2e-1 DCK P48769 Rattus norvegicus (Rat) 2 5.4875 1 1 0 Deoxycytidine kinase (dCK) (EC 2.7.1.74) Dck EAA3 P43005 Homo sapiens (Human) 3.82832108543339 5.3967578125 48 64 0 Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 CCR7 P32248 Homo sapiens (Human) 3.97954479819076 5.24375 2 2 0 C-C chemokine receptor type 7 (C-C CKR-7) (CC-CKR-7) (CCR-7) (BLR2) (CDw197) (Epstein-Barr virus-induced G-protein coupled receptor 1) (EBI1) (EBV-induced G-protein coupled receptor 1) (MIP-3 beta receptor) (CD antigen CD197) CCR7 CMKBR7 EBI1 EVI1 EGFR Q01279 Mus musculus (Mouse) 4.7307151779148 5.84686242660753 11 11 9.09090909090909 Epidermal growth factor receptor (EC 2.7.10.1) Egfr ERG7 P48449 Homo sapiens (Human) 3.57903407746121 5.3875 2 2 0 Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC) LSS OSC EDNRB P48302 Mus musculus (Mouse) 6.67333333333333 5.1875 3 3 0 Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) Ednrb IF4E P06730 Homo sapiens (Human) 4.88573750087831 5.32666666666667 9 9 0 Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) EIF4E EIF4EL1 EIF4F KCNJ3 P48549 Homo sapiens (Human) 5.4741940857008 5.31862125054201 2 12 0 G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) KCNJ3 GIRK1 KCNJ4 P48050 Homo sapiens (Human) 4 4.84875 1 1 0 Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4) KCNJ4 IRK3 KCNJ6 P48051 Homo sapiens (Human) 5.47889397507794 5.31862125054201 2 6 0 G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6) KCNJ6 GIRK2 KATP2 KCNJ7 NOS2 P35228 Homo sapiens (Human) 5.38884232104763 5.38239586548056 125 165 0 Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) NOS2 NOS2A NRAM1 P49279 Homo sapiens (Human) 5 5.17916666666667 3 3 0 Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1) SLC11A1 LSH NRAMP NRAMP1 S6A12 P48056 Rattus norvegicus (Rat) 3.20597718523608 5.20624999999999 2 12 0 Sodium- and chloride-dependent betaine transporter (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) Slc6a12 S6A11 P48066 Homo sapiens (Human) 5.60205999132796 4.9375 1 1 0 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) SLC6A11 GABT3 GAT3 SC6A6 P31641 Homo sapiens (Human) 4.52287874528034 5.2125 1 1 0 Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 OPRX P47748 Cavia porcellus (Guinea pig) 8.26 4.9875 1 1 0 Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) (XOR) OPRL1 OOR PP2BA Q08209 Homo sapiens (Human) 2.6814031185954 5.27575608589143 99 188 26.2626262626263 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) PPP3CA CALNA CNA P2RX2 P49653 Rattus norvegicus (Rat) 5.24870630994332 5.25 8 8 0 P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) P2rx2 P2RX1 P47824 Rattus norvegicus (Rat) 6.16857825733858 5.22083333333333 3 3 0 P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor) (RP-2 protein) P2rx1 P2RX3 P49654 Rattus norvegicus (Rat) 6.27834688468953 5.211625 20 27 0 P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) P2rx3 P2RY1 P47900 Homo sapiens (Human) 5.33782852108487 5.32039473684211 19 25 0 P2Y purinoceptor 1 (P2Y1) (ATP receptor) (Purinergic receptor) P2RY1 P2RY1 P49652 Meleagris gallopavo (Wild turkey) 4.64538243453535 5.49 15 40 0 P2Y purinoceptor 1 (P2Y1) (6H1 orphan receptor) (ATP receptor) (Purinergic receptor) P2RY1 P2RY1 P49651 Rattus norvegicus (Rat) 9 5.395 1 1 0 P2Y purinoceptor 1 (P2Y1) (ATP receptor) (Purinergic receptor) P2ry1 PA24A P47713 Mus musculus (Mouse) 2 6.35333333333333 3 3 0 Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] Pla2g4a Cpla2 Pla2g4 GRM5 P41594 Homo sapiens (Human) 5.56040301963636 5.23774242632225 340 445 0.882352941176471 Metabotropic glutamate receptor 5 (mGluR5) GRM5 GPRC1E MGLUR5 POL P04585 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 9.37 4.9375 1 1 0 Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pol CAN2 P43367 Sus scrofa (Pig) 2.91917121146424 5.32978535353535 132 132 42.4242424242424 Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) (Fragment) CAPN2 MMP8 P22894 Homo sapiens (Human) 6.590322072097 5.39320967741936 93 120 2.1505376344086 Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) MMP8 CLG1 Q94696 Q94696 Photuris pensylvanica (Pennsylania firefly) 5.00259512408993 5.38137720887063 822 866 82.6034063260341 Luciferase luc 5HT2A P50129 Sus scrofa (Pig) 5.6475 5.399375 4 4 0 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (5-HT2A) (Serotonin receptor 2A) HTR2A AAKG1 P54619 Homo sapiens (Human) 5.37627291247001 5.12527230122818 49 548 18.3673469387755 5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg) PRKAG1 AGTR2 P50052 Homo sapiens (Human) 4.67606693568172 5.29540790127221 145 275 18.6206896551724 Type-2 angiotensin II receptor (Angiotensin II type-2 receptor) (AT2) AGTR2 ALAT1 P25409 Rattus norvegicus (Rat) 4.71995225510778 5.3515625 2 2 0 Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) Gpt Aat1 Gpt1 ALDR P15122 Oryctolagus cuniculus (Rabbit) 4.52837252033605 5.384338125813 4 10 0 Aldose reductase (AR) (EC 1.1.1.21) (Aldehyde reductase) AKR1B1 AK1A1 P50578 Sus scrofa (Pig) 7.57 4.9 1 1 0 Alcohol dehydrogenase [NADP(+)] (EC 1.1.1.2) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1) AKR1A1 ALR ALR1 AK1A1 P51635 Rattus norvegicus (Rat) 4.98118115525768 5.12053571428571 7 7 0 Alcohol dehydrogenase [NADP(+)] (EC 1.1.1.2) (3-DG-reducing enzyme) (Aldehyde reductase) (Aldo-keto reductase family 1 member A1) Akr1a1 Alr ARY2 P50295 Mus musculus (Mouse) 4.78898267789719 5.25535714285714 7 7 0 Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) Nat2 Aac2 ATP4B P51164 Homo sapiens (Human) 5.09497503363115 5.25993827160494 27 164 0 Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain) ATP4B AT1A1 P50997 Canis lupus familiaris (Dog) (Canis familiaris) 4.83 5.94583333333333 3 6 0 Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1) ATP1A1 AT1A2 P50993 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-2) ATP1A2 KIAA0778 AT1B3 P54709 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298) ATP1B3 ADRB2 P54833 Canis lupus familiaris (Dog) (Canis familiaris) 5.02853765272014 5.20913194444444 12 12 0 Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) ADRB2 BLAN P52663 Enterobacter cloacae 6.92165886773869 5.7825 3 4 0 Imipenem-hydrolyzing beta-lactamase (EC 3.5.2.6) (Carbapenemase) (NMC-A) nmcA BPL1 P50747 Homo sapiens (Human) 4.69897000433602 4.8625 1 1 0 Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] HLCS SIA4A Q11201 Homo sapiens (Human) 4.52 5.6125 1 1 0 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A) ST3GAL1 SIAT4 SIAT4A SIAT6 Q11203 Homo sapiens (Human) 4.3 5.6125 1 1 0 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.6) (Beta-galactoside alpha-2,3-sialyltransferase 3) (Alpha 2,3-ST 3) (Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase) (N-acetyllactosaminide alpha-2,3-sialyltransferase) (ST3Gal III) (ST3GalIII) (ST3N) (Sialyltransferase 6) ST3GAL3 SIAT6 ENTP1 P49961 Homo sapiens (Human) 5.59 4.9125 1 1 0 Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39) ENTPD1 CD39 CDD P32320 Homo sapiens (Human) 5.24215905896025 5.2159375 4 6 0 Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD CDK7 P50613 Homo sapiens (Human) 5.09604228685469 5.21426792915093 150 274 7.33333333333333 Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) CDK7 CAK CAK1 CDKN7 MO15 STK1 CAC1B Q00975 Homo sapiens (Human) 4.95208251085104 5.26486056485094 77 230 18.1818181818182 Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) CACNA1B CACH5 CACNL1A5 CCR3 P51677 Homo sapiens (Human) 6.74378059994463 5.31327430555555 48 55 0 C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193) CCR3 CMKBR3 CCR4 P51679 Homo sapiens (Human) 3.03306977352081 5.2667917427819 115 196 23.4782608695652 C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194) CCR4 CMKBR4 CCR5 P51681 Homo sapiens (Human) 4.08513254666882 5.22222500328062 128 232 21.09375 C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) CCR5 CMKBR5 CLH1 Q00610 Homo sapiens (Human) 4.356 5.115 5 5 0 Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 PDE1A P54750 Homo sapiens (Human) 4.34365491216044 5.26505744949495 66 330 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) PDE1A PDE2A Q01062 Rattus norvegicus (Rat) 5.52287874528034 5.1575 1 1 0 cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) Pde2a PDE4C P14644 Rattus norvegicus (Rat) 7.52305708925833 5.584625 5 44 0 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (Fragment) Pde4c Dpde1 MMP15 P51511 Homo sapiens (Human) 2 5.385 3 3 0 Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2) MMP15 CP24A Q09128 Rattus norvegicus (Rat) 5.59 5.1625 1 1 0 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24) Cyp24a1 Cyp24 ADCY7 P51828 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) ADCY7 KIAA0037 CCNH P51946 Homo sapiens (Human) 5.8701166656724 5.19711407103825 61 180 16.3934426229508 Cyclin-H (MO15-associated protein) (p34) (p37) CCNH DRD4 P51436 Mus musculus (Mouse) 4.34242268082221 4.85 1 5 0 D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) Drd4 DRD1 P50130 Sus scrofa (Pig) 5.760560625271 5.24953125 16 17 0 D(1A) dopamine receptor (Dopamine D1 receptor) DRD1 DHB4 P51659 Homo sapiens (Human) 4.27080289113498 5.16861742158002 8 8 12.5 Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)] HSD17B4 EDH17B4 SDR8C1 DHI1 P50172 Mus musculus (Mouse) 5.71666666666667 5.3625 1 3 0 Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (11beta-HSD1A) Hsd11b1 Hsd11 DHI2 P50233 Rattus norvegicus (Rat) 4.17442409968822 5.05 1 1 0 Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) Hsd11b2 Hsd11k DPOG1 P54098 Homo sapiens (Human) 4.035 5.3125 2 2 0 DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) POLG MDP1 POLG1 POLGA DYR P00375 Mus musculus (Mouse) 7.44666666666667 5.17166666666667 3 3 0 Dihydrofolate reductase (EC 1.5.1.3) Dhfr ECE1 P42892 Homo sapiens (Human) 6.20538827563595 5.5469267394438 126 172 0 Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 EPHB1 P54762 Homo sapiens (Human) 5.5404151466677 5.18612268518519 36 56 19.4444444444444 Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2) EPHB1 ELK EPHT2 HEK6 NET ESR1 P49885 Ovis aries (Sheep) 4.7448822386369 5.01354166666667 3 10 0 Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment) ESR1 ESR NR3A1 FOLC Q05932 Homo sapiens (Human) 5.63047671250728 5.29525 10 13 0 Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) FPGS CCR8 P51685 Homo sapiens (Human) 7.01733333333333 5.22969444444444 15 18 0 C-C chemokine receptor type 8 (C-C CKR-8) (CC-CKR-8) (CCR-8) (CC chemokine receptor CHEMR1) (CMKBRL2) (Chemokine receptor-like 1) (CKR-L1) (GPR-CY6) (GPRCY6) (TER1) (CD antigen CDw198) CCR8 CKRL1 CMKBR8 CMKBRL2 MGAT2 Q10469 Homo sapiens (Human) 5.3 4.925 1 1 0 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) MGAT2 GPR4 P46093 Homo sapiens (Human) 7.47 5.21875 1 1 0 G-protein coupled receptor 4 (G-protein coupled receptor 19) GPR4 GRPR P52500 Rattus norvegicus (Rat) 7.62545454545455 4.95 11 11 0 Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor) Grpr HD P51111 Rattus norvegicus (Rat) 5 5.0375 1 1 0 Huntingtin (Huntington disease protein homolog) (HD protein homolog) Htt Hd Hdh HPRT P00493 Mus musculus (Mouse) 4.33145307634143 4.90625 2 2 0 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) (HPRT B) Hprt1 Hprt HST2 P53686 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.86239577160694 4.92270833333333 3 5 0 NAD-dependent protein deacetylase HST2 (EC 3.5.1.-) (Homologous to SIR2 protein 2) (Regulatory protein SIR2 homolog 2) HST2 YPL015C LPA2C HINT1 P49773 Homo sapiens (Human) 5.68338198942397 5.4875 3 7 0 Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) HINT1 HINT PKCI1 PRKCNH1 ITAM P11215 Homo sapiens (Human) 2 5.05833333333333 1 2 0 Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b) ITGAM CD11B CR3A LIMK2 P53671 Homo sapiens (Human) 5.99222222222222 5.25300925925926 18 21 5.55555555555556 LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) LIMK2 MAL12 P53341 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.79655374591513 5.11041666666667 3 3 0 Alpha-glucosidase MAL12 (EC 3.2.1.20) (Maltase) MAL12 MAL1S YGR292W MALX3 P53051 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.07819376376096 5.53738108365853 10 12 10 Oligo-1,6-glucosidase IMA1 (EC 3.2.1.10) (Alpha-glucosidase) (Isomaltase 1) IMA1 YGR287C MDHC P40925 Homo sapiens (Human) 3.97649018564451 5.3245 5 5 20 Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96) MDH1 MDHA MTR1B P51050 Gallus gallus (Chicken) 6.86051724137931 5.05642959770115 29 89 0 Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) (Fragment) MOT1 P53987 Rattus norvegicus (Rat) 6.75515154427619 5.35125 5 5 0 Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) Slc16a1 Mct1 MTP P55157 Homo sapiens (Human) 7.085 4.8846875 2 2 0 Microsomal triglyceride transfer protein large subunit MTTP MTP SL9A1 P26431 Rattus norvegicus (Rat) 6.90272727272727 5.20409090909091 11 11 0 Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) Slc9a1 Nhe1 SL9A2 P50482 Oryctolagus cuniculus (Rabbit) 7.39666666666667 5.06965277777778 9 27 0 Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 NOS1 P29475 Homo sapiens (Human) 5.49783329594653 5.33293735431235 143 180 0 Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS) NOS1 NOS2 Q06518 Rattus norvegicus (Rat) 4.52472269321524 5.27108901515151 22 23 0 Nitric oxide synthase, inducible (EC 1.14.13.39) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2) Nos2 NPY4R P50391 Homo sapiens (Human) 6.72766254861947 4.95916666666667 30 48 0 Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) NPY4R PPYR1 P2RX1 P51575 Homo sapiens (Human) 4.8062422790799 5.1497619047619 7 8 14.2857142857143 P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor) P2RX1 P2X1 P2RX1 P51576 Mus musculus (Mouse) 3.98829022285175 5.120625 5 5 0 P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor) P2rx1 P2RX4 P51577 Rattus norvegicus (Rat) 5.18166666666667 5.23791666666667 6 6 0 P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2rx4 P2RX6 P51579 Rattus norvegicus (Rat) 4 4.95 1 1 0 P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) P2rx6 P2rxl1 P2RY4 P51582 Homo sapiens (Human) 4.12258570305005 5.1755303030303 11 16 0 P2Y purinoceptor 4 (P2Y4) (P2P) (Uridine nucleotide receptor) (UNR) P2RY4 NRU PPAC P24666 Homo sapiens (Human) 4.34437564094425 5.41975490196078 51 95 21.5686274509804 Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1) ACP1 PAR2 P55085 Homo sapiens (Human) 5.74787434838956 4.91583333333333 5 18 0 Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2] F2RL1 GPR11 PAR2 PLGF P49764 Mus musculus (Mouse) 6.4 4.95 1 1 0 Placenta growth factor (PlGF) Pgf Plgf PPARA P23204 Mus musculus (Mouse) 3.75651890884149 5.12225 5 11 20 Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) Ppara Nr1c1 Ppar PPOX P50336 Homo sapiens (Human) 5.08333333333333 5.53333333333333 3 4 0 Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) PPOX PPP5 P53041 Homo sapiens (Human) 4.30102999566398 4.9375 2 2 0 Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT) PPP5C PPP5 PSB2 P49721 Homo sapiens (Human) 5.24618098222198 5.62257040627886 19 66 0 Proteasome subunit beta type-2 (EC 3.4.25.1) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) PSMB2 P5CR1 P54904 Arabidopsis thaliana (Mouse-ear cress) 6.73683898268365 4.9625 1 1 0 Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (Protein EMBRYO DEFECTIVE 2772) PROC1 EMB2772 At5g14800 T9L3_100 PSN1 P49768 Homo sapiens (Human) 4.97578556722111 5.14483913502109 79 912 0 Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] PSEN1 AD3 PS1 PSNL1 PSN2 P49810 Homo sapiens (Human) 4.97578556722111 5.14483913502109 79 912 0 Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] PSEN2 AD4 PS2 PSNL2 STM2 RORA P51448 Mus musculus (Mouse) 5 4.88125 1 1 0 Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) Rora Nr1f1 Rzra RORG P51450 Mus musculus (Mouse) 5.08942185509743 5.28865960858191 10301 14572 38.8408892340549 Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) (Thymus orphan receptor) (TOR) Rorc Nr1f3 Rorg Thor STAT3 P42227 Mus musculus (Mouse) 4.4825 5.30375 4 5 0 Signal transducer and activator of transcription 3 (Acute-phase response factor) Stat3 Aprf ST1E1 P49888 Homo sapiens (Human) 5.19897000433602 5.1375 2 2 50 Estrogen sulfotransferase (EC 2.8.2.4) (EST-1) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring) SULT1E1 STE CDR2 P78595 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 5.11816398578134 5.08125 2 2 50 Multidrug resistance protein CDR2 CDR2 CAALFM_C304890WA CaO19.13379 CaO19.5958 TKT P29401 Homo sapiens (Human) 6.98726037020978 5.51553240740741 9 19 0 Transketolase (TK) (EC 2.2.1.1) TKT TPIS P52270 Trypanosoma cruzi 4.66161208479668 5.13264492753623 23 29 4.34782608695652 Triosephosphate isomerase, glycosomal (TIM) (Triose-phosphate isomerase) (EC 5.3.1.1) TPMT P51580 Homo sapiens (Human) 5.4089353929735 4.9375 1 1 0 Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT KS6A3 P51812 Homo sapiens (Human) 4.17020748424443 5.27158734072212 276 702 2.89855072463768 Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) RPS6KA3 ISPK1 MAPKAPK1B RSK2 FUT5 Q11128 Homo sapiens (Human) 3.93448500216801 5.23125 2 2 50 Alpha-(1,3)-fucosyltransferase 5 (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase) FUT5 FUT6 P51993 Homo sapiens (Human) 3.69897000433602 5.6125 1 1 0 Alpha-(1,3)-fucosyltransferase 6 (EC 2.4.1.65) (Fucosyltransferase 6) (Fucosyltransferase VI) (Fuc-TVI) (FucT-VI) (Galactoside 3-L-fucosyltransferase) FUT6 FCT3A GBRB1 P50571 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) Gabrb1 GALK1 P51570 Homo sapiens (Human) 4.58341168560387 5.20611979166667 24 26 29.1666666666667 Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 GALK S15A1 P51574 Rattus norvegicus (Rat) 2.98642920015912 5.49732142857142 7 7 0 Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1) (Proton-coupled dipeptide cotransporter) Slc15a1 Pept1 PGTB1 P53610 Rattus norvegicus (Rat) 4.59886355767661 5.15775 5 10 0 Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) Pggt1b MK12 P53778 Homo sapiens (Human) 3.89773009077031 5.25898141891892 222 488 3.15315315315315 Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) MAPK12 ERK6 SAPK3 SRPK2 P78362 Homo sapiens (Human) 5.62630031122479 5.17601914414414 37 56 21.6216216216216 SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal] SRPK2 GRM7 Q14831 Homo sapiens (Human) 3.38819474641636 5.38322916666667 30 45 10 Metabotropic glutamate receptor 7 (mGluR7) GRM7 GPRC1G MGLUR7 KAPCA P00517 Bos taurus (Bovine) 5.59333333333333 5.30083333333333 3 3 0 cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) PRKACA MK11 Q15759 Homo sapiens (Human) 5.15523414479251 5.2663936728395 135 403 6.66666666666667 Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) MAPK11 PRKM11 SAPK2 SAPK2B CASP3 P42574 Homo sapiens (Human) 5.0390976048247 5.22505673987361 426 488 33.8028169014084 Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 ALK Q9UM73 Homo sapiens (Human) 4.58504955070536 5.29355807112538 263 347 3.80228136882129 ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK GRIK2 Q13002 Homo sapiens (Human) 4.57958395580126 5.48129546957672 36 73 0 Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6) GRIK2 GLUR6 AGAL Q42656 Coffea arabica (Arabian coffee) 3.02333534728363 5.27567708333333 16 16 0 Alpha-galactosidase (EC 3.2.1.22) (Alpha-D-galactoside galactohydrolase) (Melibiase) PTGIS Q16647 Homo sapiens (Human) 4.05454545454545 5.34878787878788 11 14 0 Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase) PTGIS CYP8 CYP8A1 CP51A Q64654 Rattus norvegicus (Rat) 6.93 5.4625 1 1 0 Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase) Cyp51a1 Cyp51 CPT1B Q92523 Homo sapiens (Human) 4.60041666666667 5.23631944444444 24 24 0 Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein) CPT1B KIAA1670 CPT1B Q63704 Rattus norvegicus (Rat) 5.64 4.9 1 1 0 Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein) Cpt1b KCNJ8 Q15842 Homo sapiens (Human) 6.00765143357051 5.27087152777778 24 156 0 ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1) KCNJ8 HEM6 Q42840 Hordeum vulgare (Barley) 8.52 6.61143937264017 1 1 0 Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) CPX OXDD Q99489 Homo sapiens (Human) 4.30102999566398 5.121875 1 1 0 D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO UPP1 Q16831 Homo sapiens (Human) 4.53879954801833 5.54875 3 10 0 Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP DNSL3 Q13609 Homo sapiens (Human) 4.46 5.1 1 1 0 Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD) DNASE1L3 DHP2 DNAS1L3 EST1 Q29550 Sus scrofa (Pig) 8.375 4.97916666666667 1 2 0 Liver carboxylesterase (EC 3.1.1.1) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH) 5HT4R Q62758 Rattus norvegicus (Rat) 6.01980599599727 5.38543871119651 32 132 0 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) Htr4 NK2R Q64077 Cavia porcellus (Guinea pig) 6.22903407746121 5.33559027777778 2 2 0 Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 NTR2 Q63384 Rattus norvegicus (Rat) 2 5.25 2 4 0 Neurotensin receptor type 2 (NT-R-2) (NTR2) (High-affinity levocabastine-sensitive neurotensin receptor) Ntsr2 Ntr2 GALR1 Q62805 Rattus norvegicus (Rat) 7.53 5.0875 1 1 0 Galanin receptor type 1 (GAL1-R) (GALR-1) Galr1 Galnr Galnr1 GHSR Q92847 Homo sapiens (Human) 6.8059987288109 5.24596740924092 101 172 0 Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR CCKAR Q63931 Cavia porcellus (Guinea pig) 6.665 4.99544117647059 34 34 0 Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR PD2R Q13258 Homo sapiens (Human) 6.08518203050279 5.48785854158529 29 36 0 Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor) PTGDR PD2R P70263 Mus musculus (Mouse) 6.9625 5.686875 4 8 0 Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor) Ptgdr PE2R1 P70597 Rattus norvegicus (Rat) 7.96 4.8875 1 1 0 Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) Ptger1 PE2R2 Q62053 Mus musculus (Mouse) 5.83625 5.34361742158002 8 9 0 Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) Ptger2 Ptgerep2 PE2R2 Q62928 Rattus norvegicus (Rat) 6.04 4.925 1 1 0 Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) Ptger2 P2RY6 Q15077 Homo sapiens (Human) 4.30280639584908 5.37852777777778 30 43 3.33333333333333 P2Y purinoceptor 6 (P2Y6) P2RY6 PP2891 P2RY6 Q63371 Rattus norvegicus (Rat) 5 4.9125 1 1 0 P2Y purinoceptor 6 (P2Y6) P2ry6 GRM4 Q14833 Homo sapiens (Human) 4.20107238085011 5.42988417043363 137 214 3.64963503649635 Metabotropic glutamate receptor 4 (mGluR4) GRM4 GPRC1D MGLUR4 BIRC3 Q13489 Homo sapiens (Human) 7.66045958315267 5.18020833333333 12 19 0 Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 RAGE Q15109 Homo sapiens (Human) 2.76654373289744 4.875 2 2 0 Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products) AGER RAGE FCGRN P55899 Homo sapiens (Human) 6.27967948717949 4.95 52 107 0 IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) FCGRT FCRN FNTA Q61239 Mus musculus (Mouse) 4.60470763916535 5.4555 5 10 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Fnta NTRK2 Q16620 Homo sapiens (Human) 3.89954541715885 5.28297421009634 235 288 3.82978723404255 BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) NTRK2 TRKB NTRK2 Q63604 Rattus norvegicus (Rat) 3.2 5.08327083333333 20 27 25 BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Ntrk2 Trkb PAFA Q13093 Homo sapiens (Human) 5.64140542095892 5.29630208333333 19 52 0 Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) PLA2G7 PAFAH HIF1A Q16665 Homo sapiens (Human) 5.47654487587161 5.32665871719782 320 659 24.0625 Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) HIF1A BHLHE78 MOP1 PASD8 NTCP Q14973 Homo sapiens (Human) 6.7 5.275 1 1 0 Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (Solute carrier family 10 member 1) SLC10A1 NTCP GIG29 TPPP Q27957 Bos taurus (Bovine) 4.2 5.4925 2 6 0 Tubulin polymerization-promoting protein (TPPP) (25 kDa brain-specific protein) (p25-alpha) TPPP CD5R1 Q15078 Homo sapiens (Human) 5.43159561152945 5.26332558539945 242 671 9.91735537190083 Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] CDK5R1 CDK5R NCK5A CEGT Q16739 Homo sapiens (Human) 5.70939451899404 5.37719510457317 8 8 0 Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) UGCG GRB2 Q60631 Mus musculus (Mouse) 5.38879530430873 4.95 10 39 0 Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) Grb2 HDAC1 Q13547 Homo sapiens (Human) 5.87769212568464 5.25967551332754 473 3424 0.211416490486258 Histone deacetylase 1 (HD1) (EC 3.5.1.98) HDAC1 RPD3L1 HDAC1 O09106 Mus musculus (Mouse) 7.3 4.9375 1 1 0 Histone deacetylase 1 (HD1) (EC 3.5.1.98) Hdac1 RELA Q54089 Streptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis) 5 4.8875 1 1 0 Bifunctional (p)ppGpp synthase/hydrolase RelA [Includes: GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (Stringent response-like protein) (ppGpp synthase I); Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)] relA rel SELPL Q14242 Homo sapiens (Human) 3.73051357524117 5.284375 4 4 0 P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162) SELPLG SMN Q16637 Homo sapiens (Human) 5.48869535207535 5.49135495985886 10166 10263 99.7639189455046 Survival motor neuron protein (Component of gems 1) (Gemin-1) SMN1 SMN SMNT; SMN2 SMNC VMAT2 Q27963 Bos taurus (Bovine) 6.87 5.3625 2 2 0 Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) SLC18A2 VMAT2 P2RX7 Q64663 Rattus norvegicus (Rat) 7.8 5.175 1 1 0 P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2rx7 PDE1C Q14123 Homo sapiens (Human) 4.39734703698942 5.27303093434343 66 331 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (hCam-3) PDE1C PDE1C Q63421 Rattus norvegicus (Rat) 5.25692307692308 5.32201923076923 13 39 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) Pde1c PDE6A Q28263 Canis lupus familiaris (Dog) (Canis familiaris) 6.015 4.9625 2 2 0 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) PDE6A PDEA KPCL Q64617 Rattus norvegicus (Rat) 5.79923877696554 5.17570833333333 20 192 5 Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) Prkch Pkch KPBB Q93100 Homo sapiens (Human) 6.44675833482469 5.26255208333333 4 20 0 Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) PHKB KCC4 Q16566 Homo sapiens (Human) 4.63444002041214 5.191328125 64 88 10.9375 Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV MK06 Q16659 Homo sapiens (Human) 4.94 5.33016666666667 10 13 10 Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) MAPK6 ERK3 PRKM6 MK14 P70618 Rattus norvegicus (Rat) 7.20625 5.05147569444445 8 8 0 Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) Mapk14 Csbp1 Csbp2 DUS6 Q64346 Rattus norvegicus (Rat) 4.44883830004948 5.34164141414141 33 46 9.09090909090909 Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) Dusp6 Mkp3 TRY2 Q29463 Bos taurus (Bovine) 5.69345025026263 5.264375 8 8 0 Anionic trypsin (EC 3.4.21.4) PCSK6 Q63415 Rattus norvegicus (Rat) 6.47 4.95 6 6 0 Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4) Pcsk6 Pace4 TPP2 Q64514 Mus musculus (Mouse) 5 5.375 1 1 0 Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) Tpp2 RCE1 Q03530 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.80870821330157 5.42345138888889 30 30 13.3333333333333 CAAX prenyl protease 2 (EC 3.4.22.-) (Prenyl protein-specific endoprotease 2) (PPSEP 2) (Ras and A-factor-converting enzyme) (RACE) RCE1 YMR274C YM8156.16C S15A2 Q63424 Rattus norvegicus (Rat) 3.99646539416516 5.419125 10 10 0 Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2) Slc15a2 Pept2 PYRD Q63707 Rattus norvegicus (Rat) 3.72 5.325625 4 4 0 Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) Dhodh SYPC P78600 Candida albicans (Yeast) 4.76666666666667 5.02666666666667 3 3 0 Proline--tRNA ligase, cytoplasmic (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) PRS PDIA6 Q15084 Homo sapiens (Human) 5.30102999566398 5.1625 1 1 0 Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7) PDIA6 ERP5 P5 TXNDC7 AOC3 Q16853 Homo sapiens (Human) 6.58272727272727 5.19261363636364 11 12 9.09090909090909 Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) AOC3 VAP1 ACHA5 P30532 Homo sapiens (Human) 2.19562562590174 5.20208333333333 14 90 7.14285714285714 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 NACHRA5 ACHA7 P36544 Homo sapiens (Human) 6.11216835037639 5.29071140180878 86 123 0 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 NACHRA7 ACHB3 Q05901 Homo sapiens (Human) 5.7 5.6109375 2 10 0 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 ACHB4 P30926 Homo sapiens (Human) 5.09418931892611 5.2820891064257 83 347 0 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 FAS P12785 Rattus norvegicus (Rat) 5.21375403255524 5.345 5 5 0 Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn ALR P10724 Geobacillus stearothermophilus (Bacillus stearothermophilus) 2 6.3 1 1 0 Alanine racemase (EC 5.1.1.1) alr dal XDH P47989 Homo sapiens (Human) 4.6214431873166 5.15398637820513 52 62 7.69230769230769 Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH XDHA AA3R P28647 Rattus norvegicus (Rat) 6.09405329896626 5.38522357723577 41 73 4.8780487804878 Adenosine receptor A3 (TGPCR1) Adora3 VIPR2 P41587 Homo sapiens (Human) 4.04575749056067 6.67422750325202 1 2 0 Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2) VIPR2 VIP2R FNTB P22007 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.779375 5.3946875 8 22 0 Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) RAM1 DPR1 SCG2 STE16 YDL090C D2412 MDHM P00346 Sus scrofa (Pig) 4.71937029797969 5.29773989544003 6 6 33.3333333333333 Malate dehydrogenase, mitochondrial (EC 1.1.1.37) MDH2 ASMT P10950 Bos taurus (Bovine) 4.40483613013037 5.590625 8 18 0 Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT) ASMT P4HA1 P13674 Homo sapiens (Human) 5.50032198034658 4.98359375 4 12 0 Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) P4HA1 P4HA S5A1 P24008 Rattus norvegicus (Rat) 6.53545454545455 5.26041666666667 11 21 0 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) Srd5a1 F261 P16118 Homo sapiens (Human) 4.692 5.307875 5 5 0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] PFKFB1 F6PK PFRX PPBI P19111 Bos taurus (Bovine) 5.73115846121523 5.18816666666667 25 25 0 Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) ALPI PHO85 P17157 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.30102999566398 4.95 1 1 0 Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85) PHO85 SSG3 YPL031C P7102.18A MK10 P49187 Rattus norvegicus (Rat) 4.7546179973824 5.15271707218213 23 23 0 Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) Mapk10 Jnk3 Prkm10 PTN1 P35821 Mus musculus (Mouse) 4.32871485437135 5.10583333333333 3 3 0 Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-tyrosine phosphatase HA2) (PTP-HA2) Ptpn1 PLMN P06868 Bos taurus (Bovine) 8.48 5.55 1 1 0 Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B] PLG PDIA1 P07237 Homo sapiens (Human) 4.9006750648866 5.21174603174603 21 41 4.76190476190476 Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) P4HB ERBA2L PDI PDIA1 PO4DB GALR2 O08726 Rattus norvegicus (Rat) 6.65 5.0875 1 1 0 Galanin receptor type 2 (GAL2-R) (GALR-2) Galr2 Galnr2 CTRA P00766 Bos taurus (Bovine) 4.26829942029064 5.31337946084808 34 37 0 Chymotrypsinogen A (EC 3.4.21.1) [Cleaved into: Chymotrypsin A chain A; Chymotrypsin A chain B; Chymotrypsin A chain C] THRB P00735 Bos taurus (Bovine) 4.48248064177777 5.18312601394309 120 120 12.5 Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 ACE P12822 Oryctolagus cuniculus (Rabbit) 4.45227208544022 5.34858869242003 180 275 15 Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] ACE DCP1 AA1R P25099 Rattus norvegicus (Rat) 6.04205550033544 5.28967388000901 343 451 1.16618075801749 Adenosine receptor A1 Adora1 CXCR3 P49682 Homo sapiens (Human) 6.5647437988297 5.34495772946859 69 83 0 C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183) CXCR3 GPR9 ADCY5 Q04400 Rattus norvegicus (Rat) 4.425 4.903125 4 25 0 Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) Adcy5 CNCG Q13956 Homo sapiens (Human) 5.3707378730961 5.464775 25 150 0 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma) (EC 3.1.4.35) PDE6H RK Q15835 Homo sapiens (Human) 5.52089015683996 5.33125 8 9 0 Rhodopsin kinase (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1) GRK1 RHOK PRSS8 Q16651 Homo sapiens (Human) 7.66333333333333 4.9 3 3 0 Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain] PRSS8 DRTS Q27793 Trypanosoma cruzi 7.825 4.8375 1 2 0 Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] KCMB1 Q28067 Bos taurus (Bovine) 4.3113708290022 4.8475 1 2 0 Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta) KCNMB1 NQO1 Q64669 Mus musculus (Mouse) 5.75286738362788 5.11576745014245 39 77 5.12820512820513 NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) Nqo1 Dia4 Nmo1 Nmor1 LGMN Q99538 Homo sapiens (Human) 6.385 5.20390625 4 4 0 Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1) LGMN PRSC1 METH Q99707 Homo sapiens (Human) 5.26884531229258 5.3125 1 1 0 Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) MTR MYLK P11799 Gallus gallus (Chicken) 6.56666666666667 5.02361111111111 18 18 0 Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] Mylk ACHA2 P12389 Rattus norvegicus (Rat) 6.76748983642291 5.2152038530466 93 1028 1.0752688172043 Neuronal acetylcholine receptor subunit alpha-2 Chrna2 Acra2 FKBP5 Q13451 Homo sapiens (Human) 4.3125 5.11953125 8 8 0 Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) FKBP5 AIG6 FKBP51 ADRB2 Q28044 Bos taurus (Bovine) 5.68489690609138 5.5875 1 3 0 Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) ADRB2 CASP1 P29466 Homo sapiens (Human) 4.69539309551988 5.39321448961254 685 796 25.985401459854 Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] CASP1 IL1BC IL1BCE CATK P43235 Homo sapiens (Human) 6.75081646134178 5.27258408733898 167 209 0.598802395209581 Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X) CTSK CTSO CTSO2 TRPC4 Q9QUQ5 Mus musculus (Mouse) 5.72143233359571 5.32435598203614 157 171 14.6496815286624 Short transient receptor potential channel 4 (TrpC4) (Capacitative calcium entry channel Trp4) (Receptor-activated cation channel TRP4) Trpc4 Trrp4 RNAS1 P61823 Bos taurus (Bovine) 4.57820663228874 5.2037037037037 9 25 0 Ribonuclease pancreatic (EC 3.1.27.5) (RNase 1) (RNase A) RNASE1 RNS1 ADA1A O02824 Oryctolagus cuniculus (Rabbit) 5.10068666377599 5.42916666666667 3 3 0 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) ADRA1A ADRA1C ADA1B P97717 Mus musculus (Mouse) 7 6.0625 1 3 0 Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) Adra1b APAH Q48935 Mycoplana ramosa (Mycoplana bullata) 3.56562319952358 5.43125 2 2 0 Acetylpolyamine amidohydrolase (APAH) (EC 3.5.1.-) (Acetylcadaverine deacetylase) (Acetylpolyamine deacetylase) (Acetylputrescine deacetylase) (EC 3.5.1.62) (Acetylspermidine deacetylase) (EC 3.5.1.48) aphA aph GPER1 Q99527 Homo sapiens (Human) 4.13519622464514 5.42500000000001 2 11 50 G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER) GPER1 CEPR CMKRL2 DRY12 GPER GPR30 DDX3X O00571 Homo sapiens (Human) 2 4.9625 1 1 0 ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (Helicase-like protein 2) (HLP2) DDX3X DBX DDX3 EDNRA Q29010 Sus scrofa (Pig) 6.84280750870325 5.17171052631579 19 19 0 Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) EDNRA F263 Q16875 Homo sapiens (Human) 4.70993869043662 5.48064604140446 9 18 0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] PFKFB3 GBRP O09028 Rattus norvegicus (Rat) 6.226007746773 5.15975476952344 315 6064 0.317460317460317 Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) Gabrp GASR P56481 Mus musculus (Mouse) 6.83192307692308 5.26278846153846 26 29 0 Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R) Cckbr GHSR O08725 Rattus norvegicus (Rat) 7.13958453365094 5.4625 1 3 0 Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) Ghsr KC1G2 P78368 Homo sapiens (Human) 3.9183359836414 5.23319402610442 166 229 4.81927710843374 Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) CSNK1G2 CK1G2 LEG4 P56470 Homo sapiens (Human) 5 5.42499999999999 1 1 0 Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) LGALS4 NK2R P79218 Oryctolagus cuniculus (Rabbit) 5.8 4.95 1 1 0 Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 TAC2R OPRM P97266 Cavia porcellus (Guinea pig) 6.91363414935196 5.07999061561561 111 132 0 Mu-type opioid receptor (M-OR-1) (MOR-1) (Fragment) OPRM1 PTAFR Q62035 Mus musculus (Mouse) 6.535 5 2 2 0 Platelet-activating factor receptor (PAF-R) (PAFr) Ptafr PMM2 O15305 Homo sapiens (Human) 4.10225628583817 5.16977380952381 35 40 8.57142857142857 Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) PMM2 STK11 Q15831 Homo sapiens (Human) 5.82496180504632 5.20069791666667 40 60 20 Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) STK11 LKB1 PJS CCNE1 P24864 Homo sapiens (Human) 5.81006454301803 5.27111722898475 169 701 7.10059171597633 G1/S-specific cyclin-E1 CCNE1 CCNE C11B2 P19099 Homo sapiens (Human) 6.44112734351574 5.2453078249008 200 281 0 Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (EC 1.14.15.4) (EC 1.14.15.5) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 18-hydroxylase) CYP11B2 EAA2 P43004 Homo sapiens (Human) 4.19053774099742 5.43397727272728 44 63 2.27272727272727 Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) SLC1A2 EAAT2 GLT1 LEG9 O00182 Homo sapiens (Human) 3.96498215300373 5.146875 4 4 0 Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21) LGALS9 KINA P16497 Bacillus subtilis (strain 168) 3.80447826642846 5.18185763888889 4 12 0 Sporulation kinase A (EC 2.7.13.3) (Stage II sporulation protein F) (Stage II sporulation protein J) kinA gsiC scoD spoIIF spoIIJ BSU13990 LIPG P80035 Canis lupus familiaris (Dog) (Canis familiaris) 2 5.79375 4 4 0 Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) LIPF LT4R1 Q15722 Homo sapiens (Human) 5.35246961163772 5.18159602490421 29 79 0 Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7) LTB4R BLT BLT1 BLTR CMKRL1 GPR16 P2RY7 PYGM P11217 Homo sapiens (Human) 6.44052764731388 5.12810049019608 17 17 0 Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) PYGM PPARA Q07869 Homo sapiens (Human) 5.01465121956728 5.30551143858198 132 206 2.27272727272727 Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1) PPARA NR1C1 PPAR ASIC3 Q9UHC3 Homo sapiens (Human) 4.77674566065448 5.129453125 8 11 0 Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) ASIC3 ACCN3 SLNAC1 TNAC1 POLG O92972 Hepatitis C virus genotype 1b (strain HC-J4) (HCV) 7.345 5.175 2 2 0 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] 5HT1D P79400 Sus scrofa (Pig) 6.9 5.45544270833333 16 16 0 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) (Fragment) HTR1D ADA1D P97714 Mus musculus (Mouse) 7 6.0625 1 3 0 Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) Adra1d Adra1a Gpcr8 FFAR1 O14842 Homo sapiens (Human) 5.71957496116828 5.31441287878788 44 65 0 Free fatty acid receptor 1 (G-protein coupled receptor 40) FFAR1 GPR40 FFAR3 O14843 Homo sapiens (Human) 2 5.565625 12 12 0 Free fatty acid receptor 3 (G-protein coupled receptor 41) FFAR3 GPR41 FFAR2 O15552 Homo sapiens (Human) 3.65521809839281 5.27218364197531 27 39 0 Free fatty acid receptor 2 (G-protein coupled receptor 43) FFAR2 FFA2 GPCR43 GPR43 P2Y14 Q15391 Homo sapiens (Human) 5.4496687872966 5.6796875 8 8 0 P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor) P2RY14 GPR105 KIAA0001 MURC O31211 Staphylococcus aureus 4.21240565523397 5.37427083333333 8 8 0 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase) murC PARP1 P27008 Rattus norvegicus (Rat) 5.9 5.4825 2 2 0 Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) Parp1 Adprt PDE2A O00408 Homo sapiens (Human) 5.85515971178396 5.30711449740755 97 149 2.06185567010309 cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) PDE2A PDE7A Q13946 Homo sapiens (Human) 6.07157059056598 5.30140347805551 84 94 0 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22) PDE7A PDE5A Q28156 Bos taurus (Bovine) 5.75714285714286 5.25098214285714 14 14 7.14285714285714 cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) PDE5A PDE5 CP27B O35084 Mus musculus (Mouse) 6.31875876262441 5.11999999999999 1 1 0 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.15.18) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1) Cyp27b1 Cyp27b Cyp40 PDE6D Q95142 Bos taurus (Bovine) 7.105 5.18479166666667 4 24 0 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) PDE6D FAK1 O35346 Rattus norvegicus (Rat) 4.46470670007816 4.975 1 4 0 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) Ptk2 Fak Fak1 PDK1 Q63065 Rattus norvegicus (Rat) 4.32909565797154 5.38896875 8 36 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (PDK p48) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) Pdk1 Pdh PDK2 Q64536 Rattus norvegicus (Rat) 4.32909565797154 5.38896875 8 36 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (PDK P45) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) Pdk2 PDK1 Q15118 Homo sapiens (Human) 4.34465909831822 5.39637362637362 91 173 4.3956043956044 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) PDK1 PDHK1 PDE1B Q01064 Homo sapiens (Human) 4.29866805323675 5.27422986111111 60 324 0 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (63 kDa Cam-PDE) PDE1B PDE1B1 PDES1B FAK1 Q05397 Homo sapiens (Human) 4.88344010268123 5.26767775013841 284 331 3.16901408450704 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) PTK2 FAK FAK1 KSYK Q64725 Rattus norvegicus (Rat) 2 4.93333333333333 1 1 100 Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72Syk) Syk MRP2 Q63120 Rattus norvegicus (Rat) 4.25171542115281 5.57453174603175 9 12 0 Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) Abcc2 Cmoat Cmrp Mrp2 CEL P30122 Bos taurus (Bovine) 4.82058856895085 5.24559523809524 7 7 0 Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) (Fragment) CEL GRIK4 Q01812 Rattus norvegicus (Rat) 4.58515158809733 5.33641323024055 97 646 1.03092783505155 Glutamate receptor ionotropic, kainate 4 (GluK4) (Glutamate receptor KA-1) (KA1) Grik4 GRIK5 Q63273 Rattus norvegicus (Rat) 4.5414537682562 5.325485395189 97 582 1.03092783505155 Glutamate receptor ionotropic, kainate 5 (GluK5) (Glutamate receptor KA-2) (KA2) Grik5 GRIK2 P42260 Rattus norvegicus (Rat) 4.34303146791705 5.32828166666666 125 620 0.8 Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) Grik2 Glur6 RGS12 O14924 Homo sapiens (Human) 5.05714285714286 5.20357142857143 7 7 0 Regulator of G-protein signaling 12 (RGS12) RGS12 CPNS1 P04574 Sus scrofa (Pig) 2 5.39166666666667 1 1 0 Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) CAPNS1 CAPN4 EZH2 Q15910 Homo sapiens (Human) 6.34171891409698 5.2776171875 32 56 0 Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) EZH2 KMT6 EZH1 Q92800 Homo sapiens (Human) 5.19 5.35 1 1 0 Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1) EZH1 KIAA0388 HDAC3 O15379 Homo sapiens (Human) 5.76582034650714 5.29082239672275 294 3188 0.340136054421769 Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45) HDAC3 HPPD P93836 Arabidopsis thaliana (Mouse-ear cress) 4.7 4.825 1 1 0 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) HPD PDS1 At1g06570 F12K11.9 STK16 O75716 Homo sapiens (Human) 5.17667489557431 5.26583333333333 16 22 6.25 Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK) STK16 MPSK1 PKL12 TSF1 GSTP1 P09211 Homo sapiens (Human) 5.62854943912404 5.31688988095238 14 14 0 Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) GSTP1 FAEES3 GST3 AMPC P00811 Escherichia coli (strain K12) 4.79328671334901 5.32136095298087 8954 8982 20.2591020772839 Beta-lactamase (EC 3.5.2.6) (Cephalosporinase) ampC ampA b4150 JW4111 WRN Q14191 Homo sapiens (Human) 4.43584045067112 5.3271198844103 1112 1174 23.5611510791367 Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) WRN RECQ3 RECQL2 AAKB2 O43741 Homo sapiens (Human) 5.53323963995645 5.18011017628205 52 532 17.3076923076923 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) PRKAB2 CLK4 O35493 Mus musculus (Mouse) 7.03 5.26125 2 2 0 Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) Clk4 FA10 O19045 Oryctolagus cuniculus (Rabbit) 5.72270554634038 5.1375 3 3 0 Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] F10 G6PT1 O43826 Homo sapiens (Human) 3.69897000433602 5.31875 1 1 0 Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19) SLC37A4 G6PT G6PT1 PRO0685 TRG19 MTLR O43193 Homo sapiens (Human) 6.22875 5.05078125 8 8 0 Motilin receptor (G-protein coupled receptor 38) MLNR GPR38 MTLR MTLR1 KIF3B O15066 Homo sapiens (Human) 4.30102999566398 5.4375 1 1 0 Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] KIF3B KIAA0359 KYNU Q16719 Homo sapiens (Human) 4.53353283657575 5.09583333333333 3 5 0 Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) KYNU SO1A4 O35913 Rattus norvegicus (Rat) 4.21070401616887 5.485 5 5 20 Solute carrier organic anion transporter family member 1A4 (Brain digoxin carrier protein) (Brain-specific organic anion transporter) (OATP-B1) (Sodium-independent organic anion-transporting polypeptide 2) (Solute carrier family 21 member 5) Slco1a4 Oatp1a4 Oatp2 Slc21a5 PGH1 Q63921 Rattus norvegicus (Rat) 4.70996231831232 5.18662059406713 65 133 1.53846153846154 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) Ptgs1 Cox-1 Cox1 PGH2 O02768 Oryctolagus cuniculus (Rabbit) 5.24441199826559 5.242 5 5 0 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 PGH2 O62698 Bos taurus (Bovine) 4.97420069293149 5.45818130630631 37 73 0 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 PGH2 P79208 Ovis aries (Sheep) 4.81704959893997 5.21138293650794 105 132 1.9047619047619 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 PLCB O15120 Homo sapiens (Human) 6.127328334056 5.17048611111111 12 12 0 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta) AGPAT2 PPOC O24163 Nicotiana tabacum (Common tobacco) 7.22 4.85 1 1 0 Protoporphyrinogen oxidase, chloroplastic (PPO) (EC 1.3.3.4) (Protoporphyrinogen IX oxidase isozyme I) (PPO I) (PPX I) PPXI KLK6 Q92876 Homo sapiens (Human) 2 5.161875 4 4 0 Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) KLK6 PRSS18 PRSS9 TCMO Q43054 Populus kitakamiensis (Aspen) (Populus sieboldii x Populus grandidentata) 5.28363636363636 5.17840909090909 11 11 0 Trans-cinnamate 4-monooxygenase (EC 1.14.13.11) (Cinnamic acid 4-hydroxylase) (C4H) (CA4H) (Cytochrome P450 73) (Cytochrome P450C4H) CYP73A16 CYP73 BKRB2 P25023 Rattus norvegicus (Rat) 5.783061858905 4.97916666666667 3 3 0 B2 bradykinin receptor (B2R) (BK-2 receptor) Bdkrb2 CP51A Q16850 Homo sapiens (Human) 4.49698500216801 5.25 4 4 0 Lanosterol 14-alpha demethylase (LDM) (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase) CYP51A1 CYP51 ACVL1 P37023 Homo sapiens (Human) 6.75750511068525 5.31797916666667 30 37 3.33333333333333 Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I) ACVRL1 ACVRLK1 ALK1 NMDE1 Q00959 Rattus norvegicus (Rat) 5.25689312800784 5.37614881400996 461 4487 0.433839479392625 Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) Grin2a PGH2 P35354 Homo sapiens (Human) 4.58043772468071 5.30845884989138 483 787 6.00414078674948 Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 POLG Q82122 Human rhinovirus 16 (HRV-16) 5.06098981376025 5.18625 5 6 0 Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)] STK10 O94804 Homo sapiens (Human) 4.91585290415393 5.23612969483568 71 126 12.6760563380282 Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase) STK10 LOK VHL P40337 Homo sapiens (Human) 6.39666666666667 5.43270833333333 3 3 0 von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) VHL AAPK1 Q13131 Homo sapiens (Human) 3.94987584218072 5.24888333717169 230 760 4.34782608695652 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) PRKAA1 AMPK1 O97161 O97161 Schistosoma mansoni (Blood fluke) 5.83 5.45 1 1 0 Thioredoxin peroxidase (Thioredoxin peroxidase 1) TPx-1 TPx1 POL P03354 Rous sarcoma virus (strain Prague C) (RSV-PrC) 4.305 5.03125 2 2 0 Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; Spacer peptide (SP) (p3); Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase beta-subunit (RT-beta) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Reverse transcriptase alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4] gag-pro-pol KCC2D Q13557 Homo sapiens (Human) 4.26732306679666 5.19404290429043 202 342 4.95049504950495 Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) CAMK2D CAMKD ACTB P60709 Homo sapiens (Human) 5 4.9375 1 1 0 Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] ACTB AKT2 P31751 Homo sapiens (Human) 4.40291127395697 5.28103100917279 295 376 3.38983050847458 RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) AKT2 BMR1B O00238 Homo sapiens (Human) 5.41664728165677 5.36430555555556 9 10 0 Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293) BMPR1B CP2CJ P33261 Homo sapiens (Human) 3.73239822412902 5.33898919841526 2389 2843 18.1665969024697 Cytochrome P450 2C19 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Mephenytoin 4-hydroxylase) CYP2C19 FPPS P14324 Homo sapiens (Human) 5.58228135190681 5.30080261752137 36 62 0 Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase) FDPS FPS KIAA1293 FES P07332 Homo sapiens (Human) 3.83171797858795 5.21999234068627 136 182 7.35294117647059 Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes) FES FPS GALR2 O43603 Homo sapiens (Human) 6.89618388614136 5.00551470588235 34 42 5.88235294117647 Galanin receptor type 2 (GAL2-R) (GALR-2) GALR2 GALNR2 GALR3 O60755 Homo sapiens (Human) 5.60647146191012 5.15426339285714 28 28 7.14285714285714 Galanin receptor type 3 (GAL3-R) (GALR-3) GALR3 GALNR3 5HT6R P50406 Homo sapiens (Human) 5.48583645477485 5.22989197214586 236 379 11.864406779661 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6) HTR6 M3K11 Q16584 Homo sapiens (Human) 5.85804965188522 5.3340899122807 19 23 5.26315789473684 Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) MAP3K11 MLK3 PTK1 SPRK CDKL2 Q92772 Homo sapiens (Human) 5 5.38857142857143 7 8 0 Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE) CDKL2 PAK3 O75914 Homo sapiens (Human) 4.50168249180675 5.22319230769231 65 113 10.7692307692308 Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3) PAK3 OPHN3 PMP22 Q01453 Homo sapiens (Human) 4.37572916666667 5.42814903558124 96 96 46.875 Peripheral myelin protein 22 (PMP-22) (Growth arrest-specific protein 3) (GAS-3) PMP22 GAS3 KAPCB P22694 Homo sapiens (Human) 4.76702654783548 5.2192177672956 106 324 2.83018867924528 cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) PRKACB PTBP1 P26599 Homo sapiens (Human) 4.84583333333333 5.44166666666667 36 92 83.3333333333333 Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) PTBP1 PTB RARG P13631 Homo sapiens (Human) 6.23308838422936 5.18553571428571 7 10 0 Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) RARG NR1B3 NK1R P25103 Homo sapiens (Human) 4.78582851969252 5.24066417472119 156 241 17.3076923076923 Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1) TACR1 NK1R TAC1R TNF10 P50591 Homo sapiens (Human) 5 5.49375 2 4 0 Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) TNFSF10 APO2L TRAIL TRPM2 O94759 Homo sapiens (Human) 3.82681373158773 6.0475 1 1 0 Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 UBC9 P63279 Homo sapiens (Human) 4.67125 5.09520833333333 8 24 25 SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) UBE2I UBC9 UBCE9 UBE2N P61088 Homo sapiens (Human) 4.8319489237312 5.30639622160323 88 112 11.3636363636364 Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) UBE2N BLU ULK1 O75385 Homo sapiens (Human) 5.27063795869332 5.37652777777778 9 10 0 Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) ULK1 KIAA0722 ACHA P02708 Homo sapiens (Human) 3.91445825612094 5.29453304597701 29 171 0 Acetylcholine receptor subunit alpha CHRNA1 ACHRA CHNRA DAPK3 O43293 Homo sapiens (Human) 4.26742366911935 5.24052596483784 179 207 4.46927374301676 Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase) DAPK3 ZIPK NRAM P03474 Influenza B virus (strain B/Lee/1940) 4.39794000867204 5.05625 1 1 0 Neuraminidase (EC 3.2.1.18) NA FA10 P00742 Homo sapiens (Human) 6.78790944848599 5.28426075021593 401 455 0 Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] F10 HDAC5 Q9UQL6 Homo sapiens (Human) 5.3693161845051 5.29954546429335 239 3199 0.418410041841004 Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9) HDAC5 KIAA0600 AKT3 Q9Y243 Homo sapiens (Human) 3.69989519285902 5.25717583814494 216 279 5.55555555555556 RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) AKT3 PKBG B2LA1 Q16548 Homo sapiens (Human) 5.29666666666667 4.8625 3 3 0 Bcl-2-related protein A1 (Bcl-2-like protein 5) (Bcl2-L-5) (Hemopoietic-specific early response protein) (Protein BFL-1) (Protein GRS) BCL2A1 BCL2L5 BFL1 GRS HBPA1 CDC42 P60953 Homo sapiens (Human) 4.82980874250131 5.66638288486554 13 18 0 Cell division control protein 42 homolog (G25K GTP-binding protein) CDC42 ST17B O94768 Homo sapiens (Human) 4.89664866567626 5.29958333333333 15 20 6.66666666666667 Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2) STK17B DRAK2 DYR1B Q9Y463 Homo sapiens (Human) 4.77883131151797 5.25950536339115 137 169 0.72992700729927 Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) DYRK1B MIRK EPHA7 Q15375 Homo sapiens (Human) 5.56300114557535 5.1586894379845 43 72 20.9302325581395 Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11) EPHA7 EHK3 HEK11 LATS1 O95835 Homo sapiens (Human) 5.16 5.36768518518518 9 12 11.1111111111111 Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) LATS1 WARTS MAPK3 Q16644 Homo sapiens (Human) 3.22313543581989 5.24015332397004 178 225 4.49438202247191 MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) MAPKAPK3 RAB9A P51151 Homo sapiens (Human) 5.60002379683558 5.16899091166376 8452 8626 61.5002366303833 Ras-related protein Rab-9A RAB9A RAB9 TGFR1 P36897 Homo sapiens (Human) 6.23003592096058 5.19184330150581 102 157 8.82352941176471 TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) TGFBR1 ALK5 SKR4 GP183 P32249 Homo sapiens (Human) 8.39662656831752 5.15416666666667 2 3 0 G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2) GPR183 EBI2 JAK2 O60674 Homo sapiens (Human) 5.97596471387557 5.27292962784294 606 1450 1.65016501650165 Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) JAK2 MMP14 P50281 Homo sapiens (Human) 5.39169876517626 5.47542490310078 86 98 2.32558139534884 Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) MMP14 NR0B1 P51843 Homo sapiens (Human) 4.48636673910966 5.32996922657952 153 153 49.6732026143791 Nuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1) NR0B1 AHC DAX1 KPCD3 O94806 Homo sapiens (Human) 4.50199253615388 5.25939847423146 244 976 1.22950819672131 Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) PRKD3 EPK2 PRKCN PAK4 O96013 Homo sapiens (Human) 3.90904744915541 5.20999116683182 238 286 4.20168067226891 Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) PAK4 KIAA1142 SGMR1 Q99720 Homo sapiens (Human) 4.72810547992691 5.27063119181612 161 248 16.7701863354037 Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1) SIGMAR1 OPRS1 SRBP AAG8 TRY1 P00760 Bos taurus (Bovine) 6.11504887649823 5.35819628797733 66 68 1.51515151515152 Cationic trypsin (EC 3.4.21.4) (Beta-trypsin) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2] NOD1 Q9Y239 Homo sapiens (Human) 4.98155706843802 5.16510891297968 59 84 6.77966101694915 Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4) NOD1 CARD4 PTK6 Q13882 Homo sapiens (Human) 3.77455375450201 5.2602690385525 143 191 5.59440559440559 Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK) PTK6 BRK PKN2 Q16513 Homo sapiens (Human) 4.61820146762616 5.2371875 160 192 5 Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKN2 PRK2 PRKCL2 KGP2 Q13237 Homo sapiens (Human) 3.41920730580466 5.27953472222222 120 152 0.833333333333333 cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) PRKG2 PRKGR2 STK4 Q13043 Homo sapiens (Human) 4.63232088732307 5.22834472222222 75 129 12 Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] STK4 KRS2 MST1 BTK Q06187 Homo sapiens (Human) 4.50562800509493 5.29003877133596 244 294 3.68852459016393 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) BTK AGMX1 ATK BPK FNTB Q02293 Rattus norvegicus (Rat) 6.63776940221559 5.15678728070175 38 76 0 Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) Fntb NR1I2 Q9R1A7 Rattus norvegicus (Rat) 4.59072997468987 5.2639247311828 62 72 32.258064516129 Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PXR) (Pregnane X receptor) Nr1i2 Pxr CLTR1 Q9Y271 Homo sapiens (Human) 3.26332673479316 5.28356291405214 105 213 26.6666666666667 Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) CYSLTR1 CYSLT1 NCOA2 Q15596 Homo sapiens (Human) 3.61049130169905 5.26257703081233 119 238 43.6974789915966 Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) NCOA2 BHLHE75 SRC2 TIF2 POLH Q9Y253 Homo sapiens (Human) 4.52349247568836 5.35315231366375 2512 2887 25.796178343949 DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV SGMR1 Q9R0C9 Rattus norvegicus (Rat) 6.75877974633711 5.34243503512331 75 167 0 Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) Sigmar1 Oprs1 MK14 Q16539 Homo sapiens (Human) 4.90580375148295 5.24996655062527 588 1008 5.95238095238095 Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A MMP3 P08254 Homo sapiens (Human) 6.01347192876785 5.42534229851745 153 198 2.61437908496732 Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) MMP3 STMY1 FKB1A P62942 Homo sapiens (Human) 6.72353390250815 5.36370392628205 104 175 8.65384615384615 Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) FKBP1A FKBP1 FKBP12 AMY P56634 Tenebrio molitor (Yellow mealworm beetle) 5.59 4.95 1 1 0 Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) AOC3 O70423 Mus musculus (Mouse) 3.69739407146754 4.93749999999999 2 2 0 Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) Aoc3 Vap1 BODG O75936 Homo sapiens (Human) 4.72774054604126 4.991 10 11 0 Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) BBOX1 BBH BBOX CAH4 Q95323 Bos taurus (Bovine) 6.88601915344175 5.33575390353322 133 291 0 Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) CA4 CAH12 O43570 Homo sapiens (Human) 7.1780022546477 5.28495594159113 331 479 2.11480362537764 Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) CA12 ADRB1 Q28998 Sus scrofa (Pig) 6.59 4.975 1 1 0 Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 CAH6 P18915 Bos taurus (Bovine) 4.99172063084032 5.71625 10 168 0 Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) CA6 CAC1C O35505 Cavia porcellus (Guinea pig) 6.58142857142857 5.19630847526509 7 7 0 Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) (Fragment) CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 CCNB2 O95067 Homo sapiens (Human) 5.54324272491158 5.14633839831804 109 620 9.1743119266055 G2/mitotic-specific cyclin-B2 CCNB2 CCNE2 O96020 Homo sapiens (Human) 5.85555914740308 5.28243021177118 101 528 10.8910891089109 G1/S-specific cyclin-E2 CCNE2 KCNQ3 O43525 Homo sapiens (Human) 5.79535659467845 5.26897222222222 15 36 0 Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) KCNQ3 PDE5A O54735 Rattus norvegicus (Rat) 9.55 4.85 2 2 0 cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) Pde5a Pde5 PDE6D O43924 Homo sapiens (Human) 5.59960161473802 5.42032327586207 29 154 0 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) PDE6D PDED MGLL Q99685 Homo sapiens (Human) 4.99864553709422 5.08882486979167 64 76 0 Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) MGLL GLI1 P47806 Mus musculus (Mouse) 5.19013128153495 5.28603632478633 39 52 17.9487179487179 Zinc finger protein GLI1 (Glioma-associated oncogene homolog) Gli1 Gli ACOT1 O55137 Mus musculus (Mouse) 5 5.375 1 1 0 Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.2) (CTE-I) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) Acot1 Cte1 DNAS1 P00639 Bos taurus (Bovine) 2.84948500216801 5.01875 2 2 0 Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) DNASE1 DNL1 DYR1A Q61214 Mus musculus (Mouse) 5.07096592253879 5.1375 1 2 0 Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (MP86) (Protein kinase minibrain homolog) (MNBH) Dyrk1a Dyrk DYR1A Q63470 Rattus norvegicus (Rat) 5.47452609130755 5.27016240882957 265 266 18.1132075471698 Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.2) (Dual specificity YAK1-related kinase) (Protein kinase minibrain homolog) (MNBH) (RP86) Dyrk1a Dyrk TNR6 Q63199 Rattus norvegicus (Rat) 5.0506268655951 5.425 1 2 0 Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) Fas Apt1 Tnfrsf6 GBRP O00591 Homo sapiens (Human) 6.09195841807574 5.23624669312169 63 1120 1.58730158730159 Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) GABRP GDF8 O14793 Homo sapiens (Human) 5.62973141792582 4.95 1 1 0 Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 TLK2 Q86UE8 Homo sapiens (Human) 5.76919331295752 5.15541118421053 38 61 26.3157894736842 Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) TLK2 NF2L2 Q60795 Mus musculus (Mouse) 4 5.1625 1 3 0 Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) Nfe2l2 Nrf-2 Nrf2 OPRM P79350 Bos taurus (Bovine) 6.70383341327122 5.0765625 4 6 0 Mu-type opioid receptor (M-OR-1) (MOR-1) OPRM1 SH21A O60880 Homo sapiens (Human) 5 5.2875 1 1 0 SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP) SH2D1A DSHP SAP SHH Q62226 Mus musculus (Mouse) 6.78333333333333 4.97 3 3 0 Sonic hedgehog protein (SHH) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp) (Sonic hedgehog protein 19 kDa product)] Shh Hhg1 ST1E1 P49891 Mus musculus (Mouse) 4.37333333333333 5.42361111111111 3 3 0 Estrogen sulfotransferase, testis isoform (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring) Sult1e1 Ste TRAR P33905 Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) 5.32346260323107 5.19553240740741 9 12 0 Transcriptional activator protein TraR traR VKGC O88496 Rattus norvegicus (Rat) 3.95413271344212 5.783125 4 4 0 Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) Ggcx CAC1D P27732 Rattus norvegicus (Rat) 5.80089305072688 5.41691666666667 20 74 5 Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3) Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2 CAC1S Q02485 Rattus norvegicus (Rat) 5.99909317773697 5.50442307692308 13 61 7.69230769230769 Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (ROB1) (Voltage-gated calcium channel subunit alpha Cav1.1) Cacna1s Cach1 Cacn1 Cacnl1a3 Cchl1a3 KCNQ1 P51787 Homo sapiens (Human) 4.38509301580707 5.201960990021 9 17 0 Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 KCNA8 KCNA9 KVLQT1 PDE5A O77746 Canis lupus familiaris (Dog) (Canis familiaris) 6.49167181978784 5.271 20 20 0 cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) PDE5A PDE5 DPO3A O34623 Bacillus subtilis (strain 168) 6.26 5.41616666666667 5 5 0 DNA polymerase III subunit alpha (EC 2.7.7.7) dnaE BSU29230 ESR2 Q62986 Rattus norvegicus (Rat) 3.37518674864681 5.625 4 8 0 Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) Esr2 Erbeta Nr3a2 UR2R P49684 Rattus norvegicus (Rat) 8.03434915373263 5.0525 5 7 0 Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (G-protein coupled sensory epithelial neuropeptide-like receptor) (SENR) (Urotensin II receptor) (UR-II-R) Uts2r Gpr14 Senr KC1A O19175 Sus scrofa (Pig) 4.37333333333333 5.14944444444444 18 18 5.55555555555556 Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) (Fragment) CSNK1A1 SENP6 Q9GZR1 Homo sapiens (Human) 4.75388508452659 5.20914734298955 308 341 45.1298701298701 Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) SENP6 KIAA0797 SSP1 SUSP1 FKSG6 MYH9 P35579 Homo sapiens (Human) 5 4.95 1 1 0 Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) MYH9 PRTN3 P24158 Homo sapiens (Human) 2.75 5.419375 4 4 0 Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen) PRTN3 MBN CDKL5 O76039 Homo sapiens (Human) 4.975 5.3728125 8 9 0 Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) CDKL5 STK9 5HT4R O70528 Cavia porcellus (Guinea pig) 3.0795264338084 5.26233516062415 96 174 28.125 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 ACPS P96618 Bacillus subtilis (strain 168) 4.69897000433602 5.91874266018898 1 1 0 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS) acpS ydcB BSU04620 BKRB2 O70526 Cavia porcellus (Guinea pig) 6.63844444444444 5.0015 15 20 0 B2 bradykinin receptor (B2R) (BK-2 receptor) BDKRB2 DHAS O25801 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) 6.74 5.878125 1 1 0 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) asd HP_1189 MAL1 Q17058 Apis mellifera (Honeybee) 3.35781831348052 5.275 1 3 0 Alpha-glucosidase (EC 3.2.1.20) (Maltase) MOT4 O15427 Homo sapiens (Human) 4.29710624853235 5.1765625 4 4 0 Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) SLC16A3 MCT4 NMT2 O60551 Homo sapiens (Human) 4.10133805397443 5.139375 4 9 0 Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Type II N-myristoyltransferase) NMT2 OX1R P56718 Rattus norvegicus (Rat) 6.5925 5.31630208333333 4 5 0 Orexin receptor type 1 (Ox-1-R) (Ox1-R) (Ox1R) (Hypocretin receptor type 1) Hcrtr1 PAO O64411 Zea mays (Maize) 6.3825 5.27 4 4 0 Polyamine oxidase (EC 1.5.3.14) (EC 1.5.3.15) PAO SMO Q99835 Homo sapiens (Human) 6.30676265755653 5.475 18 25 0 Smoothened homolog (SMO) (Protein Gx) SMO SMOH SMO P97698 Rattus norvegicus (Rat) 2 4.878125 1 1 0 Smoothened homolog (SMO) Smo Smoh ACHB2 P12390 Rattus norvegicus (Rat) 6.48396766885571 5.34085269420977 211 1197 0 Neuronal acetylcholine receptor subunit beta-2 (Neuronal acetylcholine receptor non-alpha-1 chain) (N-alpha 1) Chrnb2 Acrb2 HXK1 P05708 Rattus norvegicus (Rat) 4.73115468770742 5.125 1 1 0 Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) Hk1 SAHH O51933 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 3.85387196432176 5.35 1 1 0 Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) ahcY TM_0172 TERT O14746 Homo sapiens (Human) 5.11793294688411 5.23502577319588 97 165 3.09278350515464 Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2) TERT EST2 TCS1 TRT CDK10 Q15131 Homo sapiens (Human) 5.16390310480577 5.059375 2 2 0 Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE) CDK10 CRFR2 Q13324 Homo sapiens (Human) 7.06833319911468 4.94318181818182 11 24 0 Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) CRHR2 CRF2R CRH2R DRD4 P30729 Rattus norvegicus (Rat) 5.3168286870444 5.37697835558984 56 461 0 D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) Drd4 MDHC P11708 Sus scrofa (Pig) 3.0575 5.68410984316004 4 4 25 Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) MDH1 RL19A P0CX82 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.09825912003926 5.13373397435898 13 13 0 60S ribosomal protein L19-A (L23) (Large ribosomal subunit protein eL19-A) (RP15L) (RP33) (YL14) RPL19A RPL23A YL14A YBR084C-A YBR084BC VATL2 P32842 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.98822922499746 4.95 1 2 0 V-type proton ATPase subunit c' (V-ATPase subunit c') (Proteolipid protein VMA11) (Trifluoperazine resistance protein 3) (V-ATPase 16 kDa proteolipid subunit 2) (Vacuolar proton pump c' subunit) VMA11 CLS9 TFP3 YPL234C P1064 LPH Q02401 Rattus norvegicus (Rat) 4.68632333477867 5.13229166666667 3 3 0 Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] Lct Lph LYPA1 P97823 Mus musculus (Mouse) 5 5.375 2 3 0 Acyl-protein thioesterase 1 (APT-1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) Lypla1 Apt1 Pla1a BAZ2B Q9UIF8 Homo sapiens (Human) 4.489371418352 5.32052285595142 7490 15038 25.8878504672897 Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 BACE2 Q9Y5Z0 Homo sapiens (Human) 6.16752473762391 5.39117897727272 88 102 0 Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) BACE2 AEPLC ALP56 ASP21 CDA13 UNQ418/PRO852 MAO2 P76558 Escherichia coli (strain K12) 4.87333333333333 5.1 3 4 0 NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) maeB ypfF b2463 JW2447 KCNE1 Q28705 Oryctolagus cuniculus (Rabbit) 4.35189407215594 5.13125 2 2 0 Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) KCNE1 PLPL9 O60733 Homo sapiens (Human) 5.24531785686306 5.17833333333333 3 3 0 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) PLA2G6 PLPLA9 TPST2 O60704 Homo sapiens (Human) 4.96523789374079 5.05 1 1 0 Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2) TPST2 PPO2 O42713 Agaricus bisporus (White button mushroom) 4.68356583614877 5.17590755437978 81 119 3.7037037037037 Polyphenol oxidase 2 (PPO2) (Phenolase 2) (EC 1.14.18.1) (Cresolase 2) (Tyrosinase 2) PPO2 LIPP P00591 Sus scrofa (Pig) 4.512837976359 5.29135416666667 12 24 8.33333333333333 Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) PNLIP GRB2 P62993 Homo sapiens (Human) 6.04545369629738 4.96695512820513 39 42 0 Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) GRB2 ASH PTN1 P18031 Homo sapiens (Human) 4.77134091419256 5.3379852165213 360 473 0.555555555555556 Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) PTPN1 PTP1B ACES P04058 Tetronarce californica (Pacific electric ray) (Torpedo californica) 3.86765728009902 5.31708333333333 9 9 0 Acetylcholinesterase (AChE) (EC 3.1.1.7) ache RABP2 P29373 Homo sapiens (Human) 2 6.00416666666667 1 6 0 Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) CRABP2 SCYD P56221 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) 9.18111111111111 5.44416666666666 3 5 0 Scytalone dehydratase (SD) (SDH) (EC 4.2.1.94) SDH1 MGG_05059 PPCE Q9QUR6 Mus musculus (Mouse) 5 5.375 1 1 0 Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) Prep Pep MP2K7 O14733 Homo sapiens (Human) 5.47972182127254 5.19857638888889 36 57 25 Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 ADK P55263 Homo sapiens (Human) 6.06310024966674 5.3065875 50 64 0 Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) ADK NTR2 O95665 Homo sapiens (Human) 2.52422750325201 5.20625 4 4 0 Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor) NTSR2 CDK14 O94921 Homo sapiens (Human) 5.32888888888889 5.36768518518518 9 12 11.1111111111111 Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) CDK14 KIAA0834 PFTK1 KLK5 Q9Y337 Homo sapiens (Human) 5.54146523636522 5.06962121212121 11 15 9.09090909090909 Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme) KLK5 SCTE UNQ570/PRO1132 DDX1 Q92499 Homo sapiens (Human) 3.30102999566398 4.825 1 1 0 ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB) DDX1 DVL3 Q92997 Homo sapiens (Human) 3.46598000289068 5.15333333333333 3 3 0 Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) DVL3 KIAA0208 RHEB Q15382 Homo sapiens (Human) 3.91195437047216 4.925 1 2 0 GTP-binding protein Rheb (Ras homolog enriched in brain) RHEB RHEB2 SC6A3 Q01959 Homo sapiens (Human) 5.10645856654761 5.218810991891 322 468 8.07453416149068 Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) SLC6A3 DAT1 IL2 P04351 Mus musculus (Mouse) 4.51851393987789 5.8 1 1 0 Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) Il2 Il-2 PLD1 Q13393 Homo sapiens (Human) 6.72744731707319 5.287890625 16 17 0 Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 ISPE P93841 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 5.14 5.965 1 1 0 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic/chromoplastic (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) (CMK) (Ripening-associated protein pTOM41) (Fragment) ISPE DYR P00381 Lactobacillus casei 5.82927372294624 5.59756944444444 6 6 0 Dihydrofolate reductase (EC 1.5.1.3) folA dhfR LYPA2 Q9WTL7 Mus musculus (Mouse) 5 5.375 2 3 0 Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase 2) (Lysophospholipase II) (LPL-II) (LysoPLA II) (mLyso II) Lypla2 Q9K2N0 Q9K2N0 Pseudomonas aeruginosa 4.32093451280613 5.34642857142857 7 16 0 Beta-lactamase class B VIM-2 (BlaVIM-2) (Metallo beta lactamase VIM-2) (Metallo beta-lactamase) (Metallo-beta lactamase protein) (VIM-2) (VIM-2 class B beta-lactamase) (VIM-2 class B metallo b-lactamase) (VIM-2 metallo-beta-lactamase) (VIM-2 type metallo-beta-lactamase) blaVIM-2 bla vim-2 bla-VIM-2 blasVIM-2 blaVIM2 VIM-2 vim-2 PTGES O14684 Homo sapiens (Human) 5.11773753726053 5.14445928030303 44 60 6.81818181818182 Prostaglandin E synthase (EC 5.3.99.3) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein) PTGES MGST1L1 MPGES1 PGES PIG12 LUXS O34667 Bacillus subtilis (strain 168) 4.0054015504948 5.61 10 14 0 S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS) luxS ytjB BSU30670 GCYA3 Q02108 Homo sapiens (Human) 3.42697744585425 5.223125 2 10 0 Guanylate cyclase soluble subunit alpha-3 (GCS-alpha-3) (EC 4.6.1.2) (GCS-alpha-1) (Soluble guanylate cyclase large subunit) GUCY1A3 GUC1A3 GUCSA3 GUCY1A1 HDAC7 Q8WUI4 Homo sapiens (Human) 5.3145158029845 5.30143343543184 238 3093 0.420168067226891 Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) HDAC7 HDAC7A CALM P62157 Bos taurus (Bovine) 5 4.925 1 1 0 Calmodulin (CaM) CALM CAM MCL1 Q07820 Homo sapiens (Human) 4.75576892228958 5.27146584403414 175 200 27.4285714285714 Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) MCL1 BCL2L3 KS6A6 Q9UK32 Homo sapiens (Human) 4.43524517950819 5.29496527777778 66 250 13.6363636363636 Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) RPS6KA6 RSK4 IKKE Q14164 Homo sapiens (Human) 4.30566810911388 5.27678522123494 129 193 0.775193798449612 Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) IKBKE IKKE IKKI KIAA0151 MELK Q14680 Homo sapiens (Human) 4.55767162690339 5.23632280815972 192 255 4.6875 Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2) MELK KIAA0175 NUAK1 O60285 Homo sapiens (Human) 4.62428378784914 5.22375478927203 87 139 11.4942528735632 NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK1 ARK5 KIAA0537 OMPHK1 LSHR P22888 Homo sapiens (Human) 4.12165357262639 5.17138888888889 12 26 16.6666666666667 Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R) LHCGR LCGR LGR2 LHRHR POLK Q9UBT6 Homo sapiens (Human) 4.37239664587884 5.33464750215015 953 1076 20.2518363064008 DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) POLK DINB1 GEMI O75496 Homo sapiens (Human) 5.20458966266821 5.3080664759398 12574 15814 23.2622872594242 Geminin GMNN TNI3K Q59H18 Homo sapiens (Human) 5.5240625 5.25604166666667 16 20 6.25 Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) TNNI3K CARK HDAC8 Q9BY41 Homo sapiens (Human) 5.41022281787238 5.28645016130594 303 3285 0.33003300330033 Histone deacetylase 8 (HD8) (EC 3.5.1.98) HDAC8 HDACL1 CDA07 CCNA1 P78396 Homo sapiens (Human) 5.85893457667906 5.25567344852968 216 798 5.09259259259259 Cyclin-A1 CCNA1 DHB7 P56937 Homo sapiens (Human) 3.7519603273054 5.19194444444444 6 10 33.3333333333333 3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1) HSD17B7 SDR37C1 UNQ2563/PRO6243 FOXO3 O43524 Homo sapiens (Human) 5 4.8125 1 5 100 Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1) FOXO3 FKHRL1 FOXO3A NRAM2 P49281 Homo sapiens (Human) 5.8524485002168 5.14716666666667 10 12 0 Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20 PMP22 P25094 Rattus norvegicus (Rat) 5.32153642999814 5.30362196716124 109 120 20.1834862385321 Peripheral myelin protein 22 (PMP-22) (Protein CD25) (SR13 myelin protein) (Schwann cell membrane glycoprotein) (SAG) Pmp22 Cd25 Pmp-22 ACHA4 P09483 Rattus norvegicus (Rat) 6.40941183542795 5.33347845608446 232 1292 0 Neuronal acetylcholine receptor subunit alpha-4 Chrna4 Acra4 MMP13 O77656 Bos taurus (Bovine) 7.91 4.984375 2 2 0 Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) MMP13 NOS1 Q9Z0J4 Mus musculus (Mouse) 7.82 5.17499999999998 1 1 0 Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS) Nos1 NRAM P03468 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 5.2866809994516 5.18143429487179 26 32 7.69230769230769 Neuraminidase (EC 3.2.1.18) NA LCK P06239 Homo sapiens (Human) 4.24376868236752 5.23549276877256 514 717 6.6147859922179 Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK) LCK UROK P00749 Homo sapiens (Human) 5.45165668038905 5.33447393060975 120 132 0 Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B] PLAU TRXR1 O89049 Rattus norvegicus (Rat) 4.61678370807296 5.32796122062979 5855 6681 25.7216054654142 Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (NADPH-dependent thioredoxin reductase) (Thioredoxin reductase TR1) Txnrd1 Trxr1 ST32B Q9NY57 Homo sapiens (Human) 4.86268106967418 5.3169696969697 11 15 9.09090909090909 Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2) STK32B YANK2 UNQ3003/PRO9744 AGTR1 Q9WV26 Cavia porcellus (Guinea pig) 6.87 5.18333333333333 3 3 0 Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 CAH14 Q9ULX7 Homo sapiens (Human) 6.62711201479123 5.26037545787546 91 205 2.1978021978022 Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 CAH5B Q9Y2D0 Homo sapiens (Human) 6.49752896084276 5.29517592592593 45 162 4.44444444444444 Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB) CA5B DCMC O95822 Homo sapiens (Human) 6.898 5.16 5 10 0 Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9) MLYCD NFAC1 O95644 Homo sapiens (Human) 2 5.425 1 2 0 Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) NFATC1 NFAT2 NFATC S22A5 O76082 Homo sapiens (Human) 5.22912615700987 5.18 3 3 0 Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2) SLC22A5 OCTN2 S22A5 Q9Z0E8 Mus musculus (Mouse) 5.20515492583132 5.1390625 2 2 0 Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2) Slc22a5 Octn2 UR2R Q9UKP6 Homo sapiens (Human) 6.93122823470106 5.08063218390805 29 39 0 Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R) UTS2R GPR14 IRAK1 P51617 Homo sapiens (Human) 4.02596390844385 5.19744024547803 129 150 6.97674418604651 Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1) IRAK1 IRAK AA2AR P30543 Rattus norvegicus (Rat) 5.64940380326974 5.2847791175576 276 518 0.36231884057971 Adenosine receptor A2a Adora2a MRP5 O15440 Homo sapiens (Human) 4.00371012804717 5.72666666666667 3 3 33.3333333333333 Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 SCNNB P51168 Homo sapiens (Human) 2 4.85 1 3 100 Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) SCNN1B TP53B Q12888 Homo sapiens (Human) 4.59525249685356 5.55666666666667 3 3 0 TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) TP53BP1 TYSY P0A884 Escherichia coli (strain K12) 4.59 6.2375 1 1 0 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) thyA b2827 JW2795 CCNT1 O60563 Homo sapiens (Human) 7.36666857142655 5.16855282836787 102 234 7.84313725490196 Cyclin-T1 (CycT1) (Cyclin-T) CCNT1 S29A1 Q99808 Homo sapiens (Human) 5.5256460052904 5.4900625 20 27 5 Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1) SLC29A1 ENT1 S29A2 O54699 Rattus norvegicus (Rat) 5.445 5.51875 2 2 50 Equilibrative nucleoside transporter 2 (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2) Slc29a2 Ent2 NRP1 Q9QWJ9 Rattus norvegicus (Rat) 5.05741032846046 4.8125 1 1 0 Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) Nrp1 PPT2 O35448 Mus musculus (Mouse) 5 5.375 1 1 0 Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) Ppt2 EF2K O00418 Homo sapiens (Human) 3.64172121646834 5.18711622807017 114 126 6.14035087719298 Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) EEF2K TAT P04608 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 4.60544992712424 5.35469588122605 174 174 20.6896551724138 Protein Tat (Transactivating regulatory protein) tat REV P04618 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 3.98879023213323 5.19722756410256 13 13 0 Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression of viral proteins) rev Q77YF8 Q77YF8 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 7.4 4.95 2 2 0 Protein Rev (Regulator of expression of viral proteins) rev ENV P04578 Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) 4.83088235910792 5.44295634920635 21 53 33.3333333333333 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)] env TS101 Q99816 Homo sapiens (Human) 4.3432440506769 5.25449248267758 286 351 30.0699300699301 Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) TSG101 PAK6 Q9NQU5 Homo sapiens (Human) 4.9280077224651 5.23612676056338 71 110 14.0845070422535 Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6) PAK6 PAK5 ABCB6 Q9NP58 Homo sapiens (Human) 4.529883646849 6.385 1 1 0 ATP-binding cassette sub-family B member 6, mitochondrial (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter) ABCB6 MTABC3 PRP UMAT B2L10 Q9HD36 Homo sapiens (Human) 5.5003129173816 5.2625 1 1 0 Bcl-2-like protein 10 (Bcl2-L-10) (Anti-apoptotic protein NrH) (Apoptosis regulator Bcl-B) BCL2L10 BCLB KCC1D Q8IU85 Homo sapiens (Human) 3.58208128956712 5.28087911579507 127 165 6.2992125984252 Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM kinase ID) (CaM-KI delta) (CaMKI delta) (CaMKID) (CaMKI-like protein kinase) (CKLiK) CAMK1D CAMKID HUNK P57058 Homo sapiens (Human) 5.23142857142857 5.38857142857143 7 8 0 Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V) HUNK MAKV ILK Q13418 Homo sapiens (Human) 6.27571428571429 5.11713095238095 35 35 0 Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK) ILK ILK1 ILK2 TPP2 Q64560 Rattus norvegicus (Rat) 5.49272695349758 5.25637152777778 36 36 0 Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) Tpp2 CBPA1 P00730 Bos taurus (Bovine) 6.38130434782609 5.22101449275362 23 25 0 Carboxypeptidase A1 (EC 3.4.17.1) CPA1 CPA TRY2 P00763 Rattus norvegicus (Rat) 6.26801499783199 5.30499999999999 4 4 0 Anionic trypsin-2 (EC 3.4.21.4) (Anionic trypsin II) (Pretrypsinogen II) (Serine protease 2) Prss2 Try2 ESR1 P03372 Homo sapiens (Human) 4.40934318523184 5.26328472848527 578 901 12.2837370242215 Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 EPHA8 P29322 Homo sapiens (Human) 5.70480358031889 5.12861280487805 41 64 19.5121951219512 Ephrin type-A receptor 8 (EC 2.7.10.1) (EPH- and ELK-related kinase) (EPH-like kinase 3) (EK3) (hEK3) (Tyrosine-protein kinase receptor EEK) EPHA8 EEK HEK3 KIAA1459 FGF22 Q9HCT0 Homo sapiens (Human) 5.06905884874945 5.29733948087432 61 65 18.0327868852459 Fibroblast growth factor 22 (FGF-22) FGF22 UNQ2500/PRO5800 GP182 O15218 Homo sapiens (Human) 3.00436480540245 5.3375 1 1 0 G-protein coupled receptor 182 GPR182 ADMR ADA2A Q28838 Bos taurus (Bovine) 6.57142361111111 5.42574652777778 24 37 0 Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) ADRA2A RIPK4 P57078 Homo sapiens (Human) 5 5.34919270833333 8 9 0 Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) RIPK4 ANKRD3 DIK NTR1 O88319 Mus musculus (Mouse) 9.92 4.95 1 1 0 Neurotensin receptor type 1 (NT-R-1) (NTR1) Ntsr1 Ntsr PPM1D O15297 Homo sapiens (Human) 4.69897000433602 5.2609375 4 4 0 Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) PPM1D WIP1 TAB1 Q15750 Homo sapiens (Human) 6.34687005045932 5.26843137254902 17 34 0 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 NR1H2 Q60644 Mus musculus (Mouse) 4.93841271904783 5.2203125 2 9 0 Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Retinoid X receptor-interacting protein No.15) (Ubiquitously-expressed nuclear receptor) Nr1h2 Lxrb Rip15 Unr Unr2 GABR1 Q9UBS5 Homo sapiens (Human) 4.86337551850033 5.17625 3 8 0 Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) GABBR1 GPRC3A KPYR P30613 Homo sapiens (Human) 4.13058856990808 5.03017857142857 7 15 0 Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) PKLR PK1 PKL CTDS1 Q9GZU7 Homo sapiens (Human) 5.18858182620007 5.34470108695652 115 115 23.4782608695652 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 3) (NLI-IF) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1) CTDSP1 NIF3 NLIIF SCP1 5HT7R P34969 Homo sapiens (Human) 5.99629117293183 5.20120904905787 85 131 2.35294117647059 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (Serotonin receptor 7) HTR7 FFP Q9F4F7 Bacillus subtilis 4.34794732271646 5.32562103589688 3586 3705 28.6670384829894 4'-phosphopantetheinyl transferase ffp (EC 2.7.8.-) (Fengycin synthase-activating enzyme) ffp sfp B2LA1 Q07440 Mus musculus (Mouse) 4.51193391474018 5.20639492753623 46 70 6.52173913043478 Bcl-2-related protein A1 (A1-A) (Hemopoietic-specific early response protein) (Protein BFL-1) Bcl2a1 A1 Bcl2a1a Bfl1 RAMP1 O60894 Homo sapiens (Human) 6.1109375 5.6525 8 32 0 Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1) RAMP1 KLF10 Q13118 Homo sapiens (Human) 4.80112137398659 5.39375 2 6 0 Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) KLF10 TIEG TIEG1 SNAT Q29495 Ovis aries (Sheep) 4.63743863853125 5.93125 1 2 0 Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) AANAT SNAT CDK2 P24941 Homo sapiens (Human) 5.48792014087917 5.26650112197021 803 2029 1.86799501867995 Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) CDK2 CDKN2 PYGL P06737 Homo sapiens (Human) 6.19614577516577 5.41475416666667 50 64 0 Glycogen phosphorylase, liver form (EC 2.4.1.1) PYGL GRM8 P70579 Rattus norvegicus (Rat) 4.81955905139538 5.39234601449275 23 36 0 Metabotropic glutamate receptor 8 (mGluR8) Grm8 Gprc1h Mglur8 BRD1 O95696 Homo sapiens (Human) 6.4 4.9975 1 3 0 Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) BRD1 BRL BRPF2 PABP4 Q13310 Homo sapiens (Human) 2 5.6025 2 2 0 Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 GLP2R O95838 Homo sapiens (Human) 3.84801903033923 5.32916666666667 6 7 0 Glucagon-like peptide 2 receptor (GLP-2 receptor) (GLP-2-R) (GLP-2R) GLP2R GLRA1 P07727 Rattus norvegicus (Rat) 2.06614285714286 5.32392051195122 70 553 37.1428571428571 Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) Glra1 Glyr CASPE P31944 Homo sapiens (Human) 4.85 5.0375 1 1 0 Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form] CASP14 NMT1 P30419 Homo sapiens (Human) 4.95816902698721 5.6803125 8 13 0 Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) NMT1 NMT NICA Q92542 Homo sapiens (Human) 4.97578556722111 5.14483913502109 79 912 0 Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Q9BHT9 Q9BHT9 Plasmodium berghei 4.40986020482948 5.27335717247098 67 201 22.3880597014925 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase G6PD-6PGL MMP24 Q9Y5R2 Homo sapiens (Human) 2 5.6025 2 2 0 Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24] MMP24 MT5MMP PAK5 Q9P286 Homo sapiens (Human) 5.0289805601489 5.2265259009009 74 121 13.5135135135135 Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) PAK5 KIAA1264 PAK7 PDK4 O54937 Rattus norvegicus (Rat) 4.32909565797154 5.38896875 8 36 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) Pdk4 SC5A5 Q63008 Rattus norvegicus (Rat) 7.82 5.94791666666667 2 2 0 Sodium/iodide cotransporter (Na(+)/I(-) cotransporter) (Sodium-iodide symporter) (Na(+)/I(-) symporter) (Solute carrier family 5 member 5) Slc5a5 Nis XCT Q9UPY5 Homo sapiens (Human) 5.03531699173092 5.74433035714286 14 16 0 Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT) SLC7A11 S19A1 P41440 Homo sapiens (Human) 6.32166666666667 5.18249999999999 4 6 0 Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1) SLC19A1 FLOT1 RFC1 CATZ Q9UBR2 Homo sapiens (Human) 5.845 5.025 2 2 0 Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X) CTSZ CATF Q9UBX1 Homo sapiens (Human) 5.49717600346882 5.1705 5 5 0 Cathepsin F (CATSF) (EC 3.4.22.41) CTSF F262 O60825 Homo sapiens (Human) 4.8575 5.34046875 4 4 0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] PFKFB2 GPR34 Q9UPC5 Homo sapiens (Human) 4.035 5.20906249999999 8 11 0 Probable G-protein coupled receptor 34 GPR34 P2RX2 Q9UBL9 Homo sapiens (Human) 6.02481598781893 5.17275641025641 13 17 7.69230769230769 P2X purinoceptor 2 (P2X2) (ATP receptor) (Purinergic receptor) P2RX2 P2X2 ELK1 P19419 Homo sapiens (Human) 5 5.3 2 2 0 ETS domain-containing protein Elk-1 ELK1 GABR2 O88871 Rattus norvegicus (Rat) 4.70932459269023 5.18683035714286 14 28 0 Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) Gabbr2 Gpr51 GABR1 Q9Z0U4 Rattus norvegicus (Rat) 4.79320655898469 5.33352272727273 22 36 0 Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) Gabbr1 CDC7 O00311 Homo sapiens (Human) 5.78149658146127 5.22264397905759 191 245 0.523560209424084 Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) CDC7 CDC7L1 STK25 O00506 Homo sapiens (Human) 5.06917352037554 5.30793560606061 11 14 9.09090909090909 Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) STK25 SOK1 YSK1 PSA7 O14818 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-7 (EC 3.4.25.1) (Proteasome subunit RC6-1) (Proteasome subunit XAPC7) PSMA7 HSPC M3K7 O43318 Homo sapiens (Human) 5.87725723021021 5.20296783625731 57 104 17.5438596491228 Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) MAP3K7 TAK1 GABR2 O75899 Homo sapiens (Human) 4.86337551850033 5.17625 3 8 0 Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B PTN13 Q12923 Homo sapiens (Human) 4.67143937264017 5.639375 1 2 0 Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 BMPR2 Q13873 Homo sapiens (Human) 5.60408500859477 5.27055555555556 12 15 8.33333333333333 Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) BMPR2 PPH1 BRD3 Q15059 Homo sapiens (Human) 5.3338444565779 5.28271271929825 19 23 0 Bromodomain-containing protein 3 (RING3-like protein) BRD3 KIAA0043 RING3L AXIN2 Q9Y2T1 Homo sapiens (Human) 6.43 4.8225 1 1 0 Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) AXIN2 SO1B1 Q9Y6L6 Homo sapiens (Human) 5.64608425627871 5.24540316794135 131 153 17.5572519083969 Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6) SLCO1B1 LST1 OATP1B1 OATP2 OATPC SLC21A6 ACM2 P10980 Rattus norvegicus (Rat) 6.0228384048116 5.32257899579964 126 961 1.58730158730159 Muscarinic acetylcholine receptor M2 Chrm2 Chrm-2 RPOL P00573 Enterobacteria phage T7 (Bacteriophage T7) 3.69897000433602 5.1 1 1 0 T7 RNA polymerase (DNA-directed RNA polymerase) (EC 2.7.7.6) 1 INSRR P14616 Homo sapiens (Human) 4.56541019354943 5.26775704225352 71 109 14.0845070422535 Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain] INSRR IRR KCY P30085 Homo sapiens (Human) 3.82102305270683 5.375 1 2 0 UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) CMPK1 CMK CMPK UCK UMK UMPK ADCY6 O43306 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2+)-inhibitable adenylyl cyclase) ADCY6 KIAA0422 CAC1G O43497 Homo sapiens (Human) 4.16035477252672 5.11042952674897 27 37 0 Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1) CACNA1G KIAA1123 CATL2 O60911 Homo sapiens (Human) 5.30133333333333 5.33068055555556 15 17 0 Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V) CTSV CATL2 CTSL2 CTSU UNQ268/PRO305 CAH11 O75493 Homo sapiens (Human) 7.98369061957463 5.375 2 2 0 Carbonic anhydrase-related protein 11 (CA-RP XI) (CA-XI) (CARP XI) (Carbonic anhydrase-related protein 2) (CA-RP II) (CARP-2) CA11 CARP2 UNQ211/PRO237 TOP1 P11387 Homo sapiens (Human) 4.25830870999662 5.24678195883095 174 219 1.14942528735632 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 ABC3A P31941 Homo sapiens (Human) 4.54194658010327 5.34615376000134 141 152 9.21985815602837 DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.-) (Phorbolin-1) APOBEC3A SSR5 P35346 Homo sapiens (Human) 6.46379927552205 5.01283980582526 206 236 0 Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) SSTR5 SCN1A P35498 Homo sapiens (Human) 4.9277598103105 5.24569975852353 19 101 15.7894736842105 Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) SCN1A NAC1 SCN1 GSK3A P49840 Homo sapiens (Human) 5.07136056411731 5.26196821038559 344 478 2.61627906976744 Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) GSK3A MSHR Q01726 Homo sapiens (Human) 6.52075002093042 5.12185185185185 45 72 0 Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R) MC1R MSHR HMDH Q10283 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 4.1 5.209375 1 1 0 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) hmg1 its12 SPCC162.09c TBX5 Q99593 Homo sapiens (Human) 2 5.45 1 1 0 T-box transcription factor TBX5 (T-box protein 5) TBX5 6PGD P52209 Homo sapiens (Human) 3 4.825 2 2 0 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) PGD PGDH TIF1A O15164 Homo sapiens (Human) 3.28872548999644 5.01484375 4 8 0 Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24) TRIM24 RNF82 TIF1 TIF1A STK33 Q9BYT3 Homo sapiens (Human) 5.60436620821523 5.18927845528455 41 65 21.9512195121951 Serine/threonine-protein kinase 33 (EC 2.7.11.1) STK33 MA1B1 Q9UKM7 Homo sapiens (Human) 4.94632664340929 5.41875 2 2 0 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1) MAN1B1 UNQ747/PRO1477 ACEA Q9P8Q7 Candida albicans (Yeast) 3.64164715350287 5.19841666666667 10 13 0 Isocitrate lyase (ICL) (Isocitrase) (Isocitratase) (EC 4.1.3.1) (Methylisocitrate lyase) (MICA) (EC 4.1.3.30) (Threo-D(S)-isocitrate glyoxylate-lyase) ICL1 B3GT5 Q9Y2C3 Homo sapiens (Human) 3.00436480540245 5.525 1 1 0 Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5) B3GALT5 DXS Q9RUB5 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 3.36653154442041 5.3625 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) dxs DR_1475 ESR2 Q9TU15 Ovis aries (Sheep) 4.7448822386369 5.01354166666667 3 10 0 Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ESR2 NR3A2 ESR2 Q9XSB5 Bos taurus (Bovine) 3.92994019729141 5.175 2 6 0 Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ESR2 NR3A2 RGS8 P57771 Homo sapiens (Human) 4.47166666666667 5.28833333333333 6 7 0 Regulator of G-protein signaling 8 (RGS8) RGS8 BMP1 P13497 Homo sapiens (Human) 6.88912186343669 5.04375 18 19 0 Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 PCOLC CYH2 Q99418 Homo sapiens (Human) 4.72277725731773 5.25625 4 11 0 Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) CYTH2 ARNO PSCD2 PSCD2L GBRE P78334 Homo sapiens (Human) 5.96795851926568 5.227086352657 69 1248 1.44927536231884 Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) GABRE NPY5R O70342 Mus musculus (Mouse) 7.858 5.26328977059735 10 10 0 Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) Npy5r Npy5 HDAC6 Q9UBN7 Homo sapiens (Human) 5.63975707454291 5.28414079118872 337 3358 0.29673590504451 Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 ARRB1 P49407 Homo sapiens (Human) 5.05139145012356 5.375 1 1 0 Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) ARRB1 ARR1 FGFR1 P11362 Homo sapiens (Human) 4.4253522785965 5.26026512930704 403 524 2.48138957816377 Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) FGFR1 BFGFR CEK FGFBR FLG FLT2 HBGFR KCNK9 Q9NPC2 Homo sapiens (Human) 5.80966830182971 5.9625 1 1 0 Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2) (Two pore K(+) channel KT3.2) KCNK9 TASK3 ASNS P08243 Homo sapiens (Human) 5.9050612633917 5.75 2 5 0 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase) ASNS TS11 FGFR4 P22455 Homo sapiens (Human) 4.73040322092884 5.30011600378788 88 172 9.09090909090909 Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) FGFR4 JTK2 TKF MAK P20794 Homo sapiens (Human) 5.50125 5.3946875 8 9 0 Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase) MAK ITB6 P18564 Homo sapiens (Human) 6.33130164708368 5.21272727272727 11 28 0 Integrin beta-6 ITGB6 PPARG P37238 Mus musculus (Mouse) 5.66001908731661 5.0196875 8 10 12.5 Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) Pparg Nr1c3 SERHL Q9EPB5 Mus musculus (Mouse) 5 5.375 1 1 0 Serine hydrolase-like protein (SHL) (EC 3.1.-.-) Serhl LACTB Q9EP89 Mus musculus (Mouse) 5 5.375 1 1 0 Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-) Lactb Lact1 BKRB1 P97583 Rattus norvegicus (Rat) 7.9 4.95 2 2 0 B1 bradykinin receptor (B1R) (BK-1 receptor) (Kinin B1 receptor) (KB1) Bdkrb1 B1bkr Bkr PDE7B Q9NP56 Homo sapiens (Human) 6.54081521961104 5.3965625 8 11 0 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53) PDE7B DPP2 Q9EPB1 Rattus norvegicus (Rat) 4.625 5.05 2 2 0 Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) Dpp7 Dpp2 STK24 Q9Y6E0 Homo sapiens (Human) 5.24226832837755 5.15388087606838 39 74 25.6410256410256 Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 MMP26 Q9NRE1 Homo sapiens (Human) 2 4.95 1 1 0 Matrix metalloproteinase-26 (MMP-26) (EC 3.4.24.-) (Endometase) (Matrilysin-2) MMP26 PPCE Q9XTA2 Bos taurus (Bovine) 4.15 5.435 1 1 0 Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP CATD P80209 Bos taurus (Bovine) 5.51016424209218 5.17480481622429 68 73 0 Cathepsin D (EC 3.4.23.5) CTSD MYT1 Q01538 Homo sapiens (Human) 3.72124639904717 5.2625 2 4 50 Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 SP1 P08047 Homo sapiens (Human) 2 5.23608585858586 11 11 18.1818181818182 Transcription factor Sp1 SP1 TSFP1 O85361 O85361 Streptomyces plicatus 4.18948500216801 5.2125 2 2 0 B-N-acetylhexosaminidase hex Q76353 Q76353 Human immunodeficiency virus 1 7.21549921064042 5.28886842105263 19 21 0 Integrase (Fragment) CAH2 P00918 Homo sapiens (Human) 6.38997408733396 5.3114165139241 788 1123 4.06091370558376 Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) CA2 SDIS P07445 Pseudomonas putida (Arthrobacter siderocapsulatus) 4.66 7.5 1 1 100 Steroid Delta-isomerase (EC 5.3.3.1) (Delta(5)-3-ketosteroid isomerase) ksi NPFF2 Q9EQD2 Rattus norvegicus (Rat) 5.49820122281922 4.95 13 35 0 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr NPFF1 Q9GZQ6 Homo sapiens (Human) 5.49641991918987 5.04172178130512 9 16 0 Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) NPFFR1 GPR147 NPFF1 NPFF2 Q9Y5X5 Homo sapiens (Human) 6.00574182851432 5.13492063492064 6 12 0 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR RNH1 O60930 Homo sapiens (Human) 4.82666666666667 5.09916666666667 3 3 0 Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II) RNASEH1 RNH1 GBRE Q9ES14 Rattus norvegicus (Rat) 6.24186301960219 5.16056683144617 318 6112 0.314465408805031 Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) Gabre GBRA4 Q9D6F4 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) Gabra4 GBRT Q9JLF1 Mus musculus (Mouse) 4.37299339190361 5.15035714285714 7 105 0 Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) Gabrq GBRT Q9UN88 Homo sapiens (Human) 6.29429225423465 5.22655859375 80 1424 3.75 Gamma-aminobutyric acid receptor subunit theta (GABA(A) receptor subunit theta) GABRQ NAGZ Q9HZK0 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.73 5.375 1 2 0 Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) nagZ PA3005 NAGZ Q9KU37 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 4.99074303006106 5.38125 4 4 0 Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) nagZ VC_0692 GBRG3 Q99928 Homo sapiens (Human) 6.06563810270715 5.23357096354167 64 1147 1.5625 Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) GABRG3 TOP2A P11388 Homo sapiens (Human) 4.23158114855899 5.23356238214796 175 291 1.71428571428571 DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme) TOP2A TOP2 IMPA1 P97697 Rattus norvegicus (Rat) 3.75523387202732 5.4222967964165 2537 2716 37.6428852975956 Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) Impa1 Imp COT2 P24468 Homo sapiens (Human) 5.09685271762447 5.23029761904762 7 7 0 COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) NR2F2 ARP1 TFCOUP2 KKCC1 Q8N5S9 Homo sapiens (Human) 5.33487858567028 5.25176666666667 25 32 16 Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) CAMKK1 CAMKKA AAKB1 Q9Y478 Homo sapiens (Human) 5.42456485982751 5.11948736077271 52 551 17.3076923076923 5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) PRKAB1 AMPK ACM3 Q9ERZ3 Mus musculus (Mouse) 4.04773796704605 5.43375 5 26 0 Muscarinic acetylcholine receptor M3 (Mm3 mAChR) Chrm3 Chrm-3 CTRC Q99895 Homo sapiens (Human) 5.11074081472532 5.25107843137255 17 17 17.6470588235294 Chymotrypsin-C (EC 3.4.21.2) (Caldecrin) CTRC CLCR HRH4 Q9H3N8 Homo sapiens (Human) 6.293404150307 5.2799883643617 188 262 0 Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144) HRH4 GPCR105 KCC1G Q96NX5 Homo sapiens (Human) 4.77222222222222 5.32435185185185 9 13 11.1111111111111 Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase I gamma) (CaM kinase IG) (CaM-KI gamma) (CaMKI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) CAMK1G CLICK3 VWS1 ITA5 P08648 Homo sapiens (Human) 5.42950719515842 5.08784420289855 23 52 0 Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] ITGA5 FNRA TYSY P04818 Homo sapiens (Human) 5.37512022367152 5.18466616716617 77 124 0 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) TYMS TS OK/SW-cl.29 GRAB P10144 Homo sapiens (Human) 7.51 5.175 2 2 0 Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E) GZMB CGL1 CSPB CTLA1 GRB AAKG2 Q9UGJ0 Homo sapiens (Human) 5.53323963995645 5.18011017628205 52 532 17.3076923076923 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) PRKAG2 KCNQ2 O88943 Rattus norvegicus (Rat) 5.18504919978355 5.29719907407407 18 18 11.1111111111111 Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) Kcnq2 KCNQ2 O43526 Homo sapiens (Human) 5.7738630276051 5.22576388888889 18 39 0 Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) KCNQ2 IKKB O14920 Homo sapiens (Human) 5.01430630596322 5.23452870475113 260 340 3.46153846153846 Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) IKBKB IKKB NMDE1 Q12879 Homo sapiens (Human) 5.68678470812706 5.22866666666666 45 366 0 Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) GRIN2A NMDAR2A ACH4 P25162 Drosophila melanogaster (Fruit fly) 5.565625 5.49359375 8 13 0 Acetylcholine receptor subunit beta-like 2 (Nicotinic acetylcholine receptor beta 2) nAChRbeta2 Acr96Ac AcrF nAcRbeta-96 SBD CG6798 CCNB1 P14635 Homo sapiens (Human) 5.38663165693377 5.1794274949564 207 854 8.21256038647343 G2/mitotic-specific cyclin-B1 CCNB1 CCNB ADA17 O77636 Sus scrofa (Pig) 7.97 5.82181818181818 11 11 0 Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) (Fragment) ADAM17 TACE WNT3 P56703 Homo sapiens (Human) 5.52166608814999 5.461 10 16 0 Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog) WNT3 INT4 F16P1 Q9QXD6 Mus musculus (Mouse) 4.3367848463462 5.036 5 5 0 Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Fructose-1,6-bisphosphatase isozyme 3) (FBPase 3) (Liver FBPase) Fbp1 Fbp Fbp3 ICMT O60725 Homo sapiens (Human) 4.44462891686508 5.37125 8 10 0 Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) ICMT PCCMT NMDE2 Q13224 Homo sapiens (Human) 5.92628991704713 5.28603070175438 57 372 3.50877192982456 Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) GRIN2B NMDAR2B M4K5 Q9Y4K4 Homo sapiens (Human) 4.40328963522966 5.23672008547009 117 124 0.854700854700855 Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) MAP4K5 DAPK2 Q9UIK4 Homo sapiens (Human) 5.64324433313109 5.18725225225225 37 56 27.027027027027 Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) DAPK2 CAC1H O95180 Homo sapiens (Human) 5.26916141759799 5.26419254264225 83 87 28.9156626506024 Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) CACNA1H NR1I2 O75469 Homo sapiens (Human) 4.09958687823378 5.25021567717996 77 91 18.1818181818182 Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) NR1I2 PXR ALBU P02768 Homo sapiens (Human) 5.7535940143937 5.47049467519636 59 87 3.38983050847458 Serum albumin ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341 NLRP1 Q9C000 Homo sapiens (Human) 4.53222222222222 5.00416666666667 9 9 22.2222222222222 NACHT, LRR and PYD domains-containing protein 1 (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) NLRP1 CARD7 DEFCAP KIAA0926 NAC NALP1 CASP9 P55211 Homo sapiens (Human) 5.63678572992466 5.21234722222222 9 10 11.1111111111111 Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6 THYX O41156 Paramecium bursaria Chlorella virus 1 (PBCV-1) 5.756 4.91249999999999 1 5 0 Probable flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) A674R ACES O42275 Electrophorus electricus (Electric eel) (Gymnotus electricus) 4.87212366063529 5.28496880206101 220 252 2.72727272727273 Acetylcholinesterase (AChE) (EC 3.1.1.7) ache ACH10 Q9GZZ6 Homo sapiens (Human) 5.7 4.95 1 2 0 Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 ACES P23795 Bos taurus (Bovine) 3.91472350371515 5.20502884615385 26 35 0 Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE CBPM P14384 Homo sapiens (Human) 4.30102999566398 5.86145833333333 3 4 0 Carboxypeptidase M (CPM) (EC 3.4.17.12) CPM GCYB2 O75343 Homo sapiens (Human) 4.04575749056067 5.64 1 4 0 Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) GUCY1B2 GSHR P00390 Homo sapiens (Human) 4.5491373327552 5.20191666666666 15 17 0 Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) GSR GLUR GRD1 GRP78 P11021 Homo sapiens (Human) 4.82474821686171 5.30326430299888 551 562 35.2087114337568 78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) HSPA5 GRP78 MYLK2 Q9H1R3 Homo sapiens (Human) 4.67680505607669 5.21729166666667 12 16 8.33333333333333 Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) MYLK2 STK26 Q9P289 Homo sapiens (Human) 3.98883104864593 5.32757751937985 43 59 2.32558139534884 Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) STK26 MASK MST4 Q962Y6 Q962Y6 Schistosoma mansoni (Blood fluke) 4.27491280389553 5.34413713595242 4105 4111 19.537149817296 Thioredoxin glutathione reductase (EC 1.6.4.5) TGR DNAB P9WMR3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.48985491729187 5.36772206439394 264 526 20.8333333333333 Replicative DNA helicase (EC 3.6.4.12) [Cleaved into: Endonuclease PI-MtuHIP (EC 3.1.-.-) (Mtu dnaB intein)] dnaB Rv0058 MTCY21D4.21 ALF P9WQA3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.76008335489022 5.38298166666667 50 50 22 Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) fba Rv0363c MTCY13E10.25c MENB P9WNP5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.90211023087342 5.21736111111111 9 13 11.1111111111111 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36) menB Rv0548c GLMU P9WMN3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.03822014449284 5.3077850877193 19 19 31.5789473684211 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] glmU Rv1018c RECA P9WHJ3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.21465104226001 5.35607075757576 275 282 20 Protein RecA (Recombinase A) [Cleaved into: Endonuclease PI-MtuI (EC 3.1.-.-) (Mtu RecA intein)] recA Rv2737c MTV002.02c RMLD P9WH09 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2 5.28416666666667 7 7 0 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) (dTDP-4-keto-L-rhamnose reductase) (dTDP-6-deoxy-L-lyxo-4-hexulose reductase) (dTDP-6-deoxy-L-mannose dehydrogenase) (dTDP-L-rhamnose synthase) rmlD strL Rv3266c GLF P9WIQ1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.41171202466054 5.23428571428572 20 20 10 UDP-galactopyranose mutase (UGM) (EC 5.4.99.9) (UDP-GALP mutase) (Uridine 5-diphosphate galactopyranose mutase) glf Rv3809c STRP P10520 Streptococcus pyogenes serotype M1 4.79848216672831 5.27390395021645 280 502 33.2142857142857 Streptokinase A ska SPy_1979 M5005_Spy1684 KPCZ Q05513 Homo sapiens (Human) 3.99396857759586 5.21605675139053 216 915 2.77777777777778 Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) PRKCZ PKC2 CASP7 P55210 Homo sapiens (Human) 5.01236816016205 5.38296850633792 445 453 26.0674157303371 Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 MMP13 P45452 Homo sapiens (Human) 6.8169867577893 5.35416272852959 186 254 2.1505376344086 Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13) MMP13 CASP8 Q14790 Homo sapiens (Human) 5.71801195058458 5.31166364295006 35 36 2.85714285714286 Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 DCAM P17707 Homo sapiens (Human) 5.68409152601106 5.364140625 16 16 0 S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] AMD1 AMD MAZF P0AE70 Escherichia coli (strain K12) 3.62439331183142 5.2785670045045 74 154 37.8378378378378 Endoribonuclease toxin MazF (EC 3.1.27.-) (Toxin MazF) (mRNA interferase MazF) mazF chpA chpAK b2782 JW2753 RECD P04993 Escherichia coli (strain K12) 3.92745285896788 5.38675 15 45 26.6666666666667 RecBCD enzyme subunit RecD (EC 3.1.11.5) (Exodeoxyribonuclease V 67 kDa polypeptide) (Exodeoxyribonuclease V alpha chain) (Exonuclease V subunit RecD) (ExoV subunit RecD) (Helicase/nuclease RecBCD subunit RecD) recD hopE b2819 JW2787 RECB P08394 Escherichia coli (strain K12) 3.92745285896788 5.38675 15 45 26.6666666666667 RecBCD enzyme subunit RecB (EC 3.1.11.5) (Exodeoxyribonuclease V 135 kDa polypeptide) (Exodeoxyribonuclease V beta chain) (Exonuclease V subunit RecB) (ExoV subunit RecB) (Helicase/nuclease RecBCD subunit RecB) recB ior rorA b2820 JW2788 RECC P07648 Escherichia coli (strain K12) 3.92745285896788 5.38675 15 45 26.6666666666667 RecBCD enzyme subunit RecC (EC 3.1.11.5) (Exodeoxyribonuclease V 125 kDa polypeptide) (Exodeoxyribonuclease V gamma chain) (Exonuclease V subunit RecC) (ExoV subunit RecC) recC b2822 JW2790 PLK4 O00444 Homo sapiens (Human) 4.20131088289707 5.22457692307692 130 136 3.07692307692308 Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak) PLK4 SAK STK18 KCNN2 P70604 Rattus norvegicus (Rat) 3.99520111711823 4.8625 1 3 0 Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) Kcnn2 KCNN3 P70605 Rattus norvegicus (Rat) 5.87174623499447 5.16935185185185 9 12 11.1111111111111 Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3) Kcnn3 KCNN1 P70606 Rattus norvegicus (Rat) 3.99520111711823 4.8625 1 3 0 Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1) Kcnn1 Sk1 HRH3 Q9QYN8 Rattus norvegicus (Rat) 7.46566730037058 5.26715544871795 52 71 0 Histamine H3 receptor (H3R) (HH3R) Hrh3 KCNN4 O15554 Homo sapiens (Human) 5.31643937264017 5.015625 4 4 0 Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel) KCNN4 IK1 IKCA1 KCA4 SK4 HRH3 P58406 Mus musculus (Mouse) 4.04139268515823 5.2625 1 1 0 Histamine H3 receptor (H3R) (HH3R) Hrh3 HRH3 Q9JI35 Cavia porcellus (Guinea pig) 6.98442705425328 5.24053571428571 35 45 0 Histamine H3 receptor (H3R) (HH3R) HRH3 DPOLM Q9NP87 Homo sapiens (Human) 3.69897000433602 5.1 1 1 0 DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) POLM polmu KCNN3 Q9UGI6 Homo sapiens (Human) 5.08679700565888 5.09945833333333 10 18 30 Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3) KCNN3 K3 DPOLL Q9UGP5 Homo sapiens (Human) 4.55349651181015 5.21339285714286 7 13 0 DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa) POLL NEUR1 Q99519 Homo sapiens (Human) 3.945 4.946875 2 2 0 Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1) NEU1 NANH SPHK1 Q9NYA1 Homo sapiens (Human) 3.85099312623243 5.34617447916667 40 51 0 Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) SPHK1 SPHK SPK NEUR3 Q9UQ49 Homo sapiens (Human) 3.89594403844591 5.11866071428571 7 8 0 Sialidase-3 (EC 3.2.1.18) (Ganglioside sialidase) (Membrane sialidase) (N-acetyl-alpha-neuraminidase 3) NEU3 BAD Q92934 Homo sapiens (Human) 4.96903547632943 5.30416666666667 3 4 0 Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) BAD BBC6 BCL2L8 EBP Q15125 Homo sapiens (Human) 6.6025 5.235625 4 5 0 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) EBP DNM3B Q9UBC3 Homo sapiens (Human) 5.33443875151028 5.240625 8 24 0 DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) DNMT3B TM11D O60235 Homo sapiens (Human) 7.2825 5.915625 4 4 0 Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain] TMPRSS11D HAT INMT O97972 Oryctolagus cuniculus (Rabbit) 5.16115090926274 4.9125 1 1 0 Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) INMT MBP P04370 Mus musculus (Mouse) 2 5.1125 2 2 0 Myelin basic protein (MBP) (Myelin A1 protein) Mbp Shi PAG P13423 Bacillus anthracis 3.89166666666667 5.08125 2 16 50 Protective antigen (PA) (Anthrax toxins translocating protein) (PA-83) (PA83) [Cleaved into: Protective antigen PA-20 (PA20); Protective antigen PA-63 (PA63)] pagA pag pXO1-110 BXA0164 GBAA_pXO1_0164 PARP2 O88554 Mus musculus (Mouse) 5.922 5.1249375 10 10 0 Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) Parp2 Adprt2 Adprtl2 Aspartl2 PARP2 Q9UGN5 Homo sapiens (Human) 6.08991634291035 5.22115277777778 15 21 0 Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) PARP2 ADPRT2 ADPRTL2 PSB7 Q99436 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) PSMB7 Z VEGFA P15692 Homo sapiens (Human) 6.70915085914058 5.02954545454546 11 12 0 Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF PLGF P49763 Homo sapiens (Human) 6.04375 4.95 8 10 0 Placenta growth factor (PlGF) PGF PGFL PLGF DEF Q9I7A8 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 7.38 4.975 1 1 0 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) def PA0019 DEFM Q9HBH1 Homo sapiens (Human) 4.8138820291355 5.132890625 8 9 0 Peptide deformylase, mitochondrial (EC 3.5.1.88) (Polypeptide deformylase) PDF PDF1A CBX7 O95931 Homo sapiens (Human) 4.76541853171175 5.19824404761905 7 9 0 Chromobox protein homolog 7 CBX7 SC5A4 Q9NY91 Homo sapiens (Human) 7.674 5.1695 5 5 0 Solute carrier family 5 member 4 SLC5A4 SAAT1 SGLT3 GLD1 Q17339 Caenorhabditis elegans 5.05037125694559 5.25486111111111 12 12 0 Female germline-specific tumor suppressor gld-1 (Defective in germ line development protein 1) gld-1 T23G11.3 MEX5 Q9XUB2 Caenorhabditis elegans 4.20412724601611 5.34875607763006 220 220 21.3636363636364 Zinc finger protein mex-5 mex-5 W02A2.7 G5EF15 G5EF15 Caenorhabditis elegans 4.03733348030588 5.33742450305811 218 218 22.0183486238532 Cytoplasmic zinc-finger protein (POsterior Segregation) pos-1 CELE_F52E1.1 F52E1.1 GHRL Q9UBU3 Homo sapiens (Human) 5.7975 5.40822916666666 4 4 0 Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin] GHRL MTLRP UNQ524/PRO1066 HS90B P08238 Homo sapiens (Human) 5.15992533554874 5.3491111392017 188 414 5.85106382978723 Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) HSP90AB1 HSP90B HSPC2 HSPCB EPHB3 P54753 Homo sapiens (Human) 4.18344550853679 5.25547916666666 70 103 4.28571428571429 Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) EPHB3 ETK2 HEK2 TYRO6 SOAT1 O70536 Rattus norvegicus (Rat) 5.03069090924218 5.32751208761533 47 51 0 Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Soat1 Acact Acat SOAT2 O75908 Homo sapiens (Human) 6.15452540000581 5.1609375 16 17 0 Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) SOAT2 ACACT2 ACAT2 EBP Q60490 Cavia porcellus (Guinea pig) 7.41 5.04666666666667 3 3 0 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) EBP NMDE4 Q62645 Rattus norvegicus (Rat) 5.34552151492057 5.37918741904083 441 4421 0.453514739229025 Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D) Grin2d GluN2D PRGR Q63449 Rattus norvegicus (Rat) 3.80502339678395 5.425 1 1 100 Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) Pgr Nr3c3 ADK Q9TVW2 Toxoplasma gondii 5.08 4.9125 1 2 0 Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) AK ENTP2 Q9Y5L3 Homo sapiens (Human) 3.69897000433602 4.9125 1 1 0 Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase 2) (EC 3.6.1.-) (CD39 antigen-like 1) (Ecto-ATP diphosphohydrolase 2) (Ecto-ATPDase 2) (Ecto-ATPase 2) ENTPD2 CD39L1 BACE1 P56818 Mus musculus (Mouse) 6.98 5.555 2 2 0 Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Bace1 Bace OXYR P70536 Rattus norvegicus (Rat) 6.88538461538462 5.04259615384615 13 13 0 Oxytocin receptor (OT-R) Oxtr Otr PBPA Q04707 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 6.37785374847438 5.4 1 9 0 Penicillin-binding protein 1A (PBP-1A) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] ponA SP_0369 EDNRA P25101 Homo sapiens (Human) 5.689566272712 5.31541854671164 291 383 9.27835051546392 Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) EDNRA ETA ETRA RICI P02879 Ricinus communis (Castor bean) 3.70604349720264 5.48770833333333 5 6 0 Ricin [Cleaved into: Ricin A chain (EC 3.2.2.22) (rRNA N-glycosidase); Linker peptide; Ricin B chain] RXFP2 Q8WXD0 Homo sapiens (Human) 4.7909518058728 5.37905299642218 43 43 9.30232558139535 Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2) RXFP2 GPR106 GREAT LGR8 NEK7 Q8TDX7 Homo sapiens (Human) 4.84154536001576 5.24429924242424 66 107 4.54545454545455 Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NEK7 M3K20 Q9NYL2 Homo sapiens (Human) 2.982 5.23356041666667 100 103 1 Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) MAP3K20 MLTK ZAK HCCS4 CP24A Q07973 Homo sapiens (Human) 6.805 4.875 2 2 0 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24) CYP24A1 CYP24 ABCC8 Q09429 Rattus norvegicus (Rat) 5.4981102361441 5.471875 4 9 0 ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) Abcc8 Sur Sur1 KIF22 Q14807 Homo sapiens (Human) 2 5.1285 5 5 0 Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) KIF22 KID KNSL4 CAN1 P35750 Sus scrofa (Pig) 7.12944444444444 5.334375 9 16 0 Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) CAPN1 ACHA3 P32297 Homo sapiens (Human) 4.90954220366735 5.30591197257384 79 340 0 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 NACHRA3 RUNX1 Q01196 Homo sapiens (Human) 4.77685858758875 5.30629069286011 1029 2162 36.6375121477162 Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 NEK6 Q9HC98 Homo sapiens (Human) 4.70682458452411 5.21980046948357 71 109 8.45070422535211 Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) NEK6 KPCD2 Q9BZL6 Homo sapiens (Human) 4.15773931789262 5.24814166666667 200 235 3 Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) PRKD2 PKD2 HSPC187 KS6A2 Q15349 Homo sapiens (Human) 4.51683149159818 5.25774166666667 75 270 10.6666666666667 Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) RPS6KA2 MAPKAPK1C RSK3 SL9A2 Q9UBY0 Homo sapiens (Human) 4.89 4.975 1 1 0 Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 APEH Q8R146 Mus musculus (Mouse) 5 5.375 1 1 0 Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) Apeh ANM6 Q96LA8 Homo sapiens (Human) 7.53 5.03125 2 3 0 Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) (Histone-arginine N-methyltransferase PRMT6) PRMT6 HRMT1L6 ANM7 Q9NVM4 Homo sapiens (Human) 4.30102999566398 5.35 1 1 0 Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) PRMT7 KIAA1933 APEL Q9ULZ1 Homo sapiens (Human) 5.722 4.95 5 5 0 Apelin (APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13] APLN APEL CLTR2 Q9NS75 Homo sapiens (Human) 6.43812302738335 5.32150173611111 32 71 3.125 Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321) CYSLTR2 CYSLT2 CYSLT2R PSEC0146 DHCR7 Q9UBM7 Homo sapiens (Human) 3.5 5.04125 2 4 0 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Putative sterol reductase SR-2) (Sterol Delta(7)-reductase) DHCR7 D7SR FUT8 Q9BYC5 Homo sapiens (Human) 5.7 4.95 1 1 0 Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) FUT8 ISPE Q8ZEY1 Yersinia pestis 4.82 5.5625 1 1 0 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) ispE ipk YPO2014 y2293 YP_1862 NSMA Q9ET64 Rattus norvegicus (Rat) 5.60205999132796 4.88749999999999 1 1 0 Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) Smpd2 PIM2 Q9P1W9 Homo sapiens (Human) 5.21083157783834 5.22271437455579 335 393 2.08955223880597 Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h) PIM2 PA2GD Q9UNK4 Homo sapiens (Human) 5.62 5.875 1 1 0 Group IID secretory phospholipase A2 (GIID sPLA2) (sPLA2-IID) (EC 3.1.1.4) (PLA2IID) (Phosphatidylcholine 2-acylhydrolase 2D) (Secretory-type PLA, stroma-associated homolog) PLA2G2D SPLASH SRR Q9GZT4 Homo sapiens (Human) 4.89447764165089 5.1515625 8 9 0 Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR SRR Q9QZX7 Mus musculus (Mouse) 3.25598000289068 5.76666666666667 3 3 0 Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) Srr SEPR P97321 Mus musculus (Mouse) 5.43315142733257 5.26575793650794 21 21 0 Prolyl endopeptidase FAP (EC 3.4.21.26) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)] Fap SPHK2 Q9JIA7 Mus musculus (Mouse) 4.68677699785691 5.26541666666667 6 6 0 Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Sphk2 TLR3 O15455 Homo sapiens (Human) 3.30434782608696 5.11851449275362 23 25 0 Toll-like receptor 3 (CD antigen CD283) TLR3 TLR2 O60603 Homo sapiens (Human) 5.07816276212228 5.17234724495362 47 65 0 Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282) TLR2 TIL4 TADBP Q13148 Homo sapiens (Human) 4.96701779849399 5.25430309905159 5861 5870 24.8592390377069 TAR DNA-binding protein 43 (TDP-43) TARDBP TDP43 TLR6 Q9EPW9 Mus musculus (Mouse) 2.75 5.255025 10 40 0 Toll-like receptor 6 (CD antigen CD286) Tlr6 TLR9 Q9NR96 Homo sapiens (Human) 3.96840909090909 5.1702178030303 44 46 11.3636363636364 Toll-like receptor 9 (CD antigen CD289) TLR9 UNQ5798/PRO19605 TLR8 Q9NR97 Homo sapiens (Human) 3.59145034832082 5.18987561367496 37 41 0 Toll-like receptor 8 (CD antigen CD288) TLR8 UNQ249/PRO286 TLR7 Q9NYK1 Homo sapiens (Human) 4.93107359731131 5.25857638888889 60 76 0 Toll-like receptor 7 TLR7 UNQ248/PRO285 TLR4 Q9QUK6 Mus musculus (Mouse) 3.62285714285714 5.23966071428571 14 23 0 Toll-like receptor 4 (CD antigen CD284) Tlr4 Lps TLR2 Q9QUN7 Mus musculus (Mouse) 2.75 5.255025 10 40 0 Toll-like receptor 2 (CD antigen CD282) Tlr2 APAF O14727 Homo sapiens (Human) 4.34751111111111 5.4323 75 135 18.6666666666667 Apoptotic protease-activating factor 1 (APAF-1) APAF1 KIAA0413 ADA2C P18825 Homo sapiens (Human) 4.10227003682417 5.25519705501079 147 325 19.047619047619 Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) ADRA2C ADRA2L2 ADRA2RL2 ATNG P54710 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain) FXYD2 ATP1C ATP1G1 PDE4C Q08493 Homo sapiens (Human) 5.58386979592429 5.28281750001777 183 833 0.546448087431694 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) PDE4C DPDE1 HCK P08631 Homo sapiens (Human) 5.22284411419865 5.26651359953704 132 236 7.57575757575758 Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck) HCK GBRG2 P22723 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) Gabrg2 GRK6 P43250 Homo sapiens (Human) 4.75839681745261 5.2249240819209 59 101 15.2542372881356 G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6) GRK6 GPRK6 KLK P00752 Sus scrofa (Pig) 4.28 4.975 1 1 0 Glandular kallikrein (EC 3.4.21.35) (Tissue kallikrein) KPCB P05771 Homo sapiens (Human) 5.97115139421688 5.31063577407051 253 1101 2.76679841897233 Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) PRKCB PKCB PRKCB1 KPCD P28867 Mus musculus (Mouse) 8.97452380952381 5.52202380952381 3 11 0 Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] Prkcd Pkcd HTRA2 Q9JIY5 Mus musculus (Mouse) 5 5.375 1 1 0 Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) Htra2 Omi Prss25 SAHH P23526 Homo sapiens (Human) 5.73712133613052 5.64116379310345 29 50 0 Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) AHCY SAHH RN5A Q05921 Mus musculus (Mouse) 6.11908002710525 4.95 21 26 0 2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L) Rnasel Rns4 TGM2 P21980 Homo sapiens (Human) 5.78691634982578 5.26365079365079 21 28 0 Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2) TGM2 TOP2B Q02880 Homo sapiens (Human) 4.58977932768746 5.13178931212375 53 147 3.77358490566038 DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme) TOP2B NF2L2 Q16236 Homo sapiens (Human) 5.1264368423808 5.2553120682309 13500 15093 37.1259259259259 Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) NFE2L2 NRF2 TRY3 P35030 Homo sapiens (Human) 5.52750630178972 5.406364759887 118 356 0.847457627118644 Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV) PRSS3 PRSS4 TRY3 TRY4 TYDP1 Q9NUW8 Homo sapiens (Human) 3.61241356372566 5.31101076305398 1509 1629 28.8933068257124 Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 AAPK2 P54646 Homo sapiens (Human) 4.79486281450862 5.24083875868055 96 608 10.4166666666667 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) PRKAA2 AMPK AMPK2 HG2A P04233 Homo sapiens (Human) 4.624204089882 5.13221590909091 22 40 0 HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74) CD74 DHLAG NEK3 P51956 Homo sapiens (Human) 5.67678144401089 5.1325 34 49 26.4705882352941 Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (HSPK 36) (Never in mitosis A-related kinase 3) (NimA-related protein kinase 3) NEK3 KS6A1 Q15418 Homo sapiens (Human) 4.72373338891166 5.23821465163934 122 390 8.19672131147541 Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) RPS6KA1 MAPKAPK1A RSK1 PPGB P10619 Homo sapiens (Human) 5.51271514981121 5.42575416666667 50 50 0 Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] CTSA PPGB PAR1 P25116 Homo sapiens (Human) 6.12040400630145 5.24377604166667 24 50 0 Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor) F2R CF2R PAR1 TR SYMC P56192 Homo sapiens (Human) 4.42478028471148 5.24375 8 8 0 Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) MARS SYK Q15046 Homo sapiens (Human) 6.40128787452803 5.4819375 10 10 0 Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) KARS KIAA0070 IRAK4 Q9NWZ3 Homo sapiens (Human) 4.45380832582251 5.24348953974896 239 298 4.60251046025105 Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 MALT1 Q9UDY8 Homo sapiens (Human) 5.326 5.4005 5 5 0 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT RL3R1 Q9NSD7 Homo sapiens (Human) 6.072 4.95 5 6 0 Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor) RXFP3 RLN3R1 SALPR TBA3C Q13748 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin alpha-3C/D chain (Alpha-tubulin 2) (Alpha-tubulin 3C/D) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C/D chain] TUBA3C TUBA2; TUBA3D TBA1C Q9BQE3 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] TUBA1C TUBA6 BCAT2 O15382 Homo sapiens (Human) 5.6375 5.2815625 4 5 0 Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42) (Placental protein 18) (PP18) BCAT2 BCATM BCT2 ECA40 TBB3 Q13509 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) TUBB3 TUBB4 PRP4 O43172 Homo sapiens (Human) 6.13 5.58125 2 2 0 U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) PRPF4 PRP4 KDSA Q9JZ55 Neisseria meningitidis serogroup B (strain MC58) 3.29251332601459 5.3578125 2 2 0 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (3-deoxy-D-manno-octulosonic acid 8-phosphate synthase) (KDO-8-phosphate synthase) (KDO 8-P synthase) (KDOPS) (Phospho-2-dehydro-3-deoxyoctonate aldolase) kdsA NMB1283 PSD10 O75832 Homo sapiens (Human) 3.52623238728793 4.9975 1 1 0 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 AK1C2 P52895 Homo sapiens (Human) 4.96394406059127 5.25752570572035 74 80 2.7027027027027 Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) AKR1C2 DDH2 CBPB1 P15086 Homo sapiens (Human) 6.63666666666667 5.40760416666667 12 12 0 Carboxypeptidase B (EC 3.4.17.2) (Pancreas-specific protein) (PASP) CPB1 CPB PCPB CSF1R P09581 Mus musculus (Mouse) 8.13636363636364 5.40651515151515 11 11 0 Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) Csf1r Csfmr Fms PSB6 P28072 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y) PSMB6 LMPY Y PSB3 P49720 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) PSMB3 WNT3A P56704 Homo sapiens (Human) 5.41700999855466 5.14972222222222 3 3 0 Protein Wnt-3a WNT3A PPB P00634 Escherichia coli (strain K12) 2 4.85 1 1 0 Alkaline phosphatase (APase) (EC 3.1.3.1) phoA b0383 JW0374 AROQ P15474 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 3.61932375181632 5.18125 4 4 0 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) aroQ SCO1961 SCC54.21c GSTA1 P08263 Homo sapiens (Human) 5.95691145708377 5.12777777777777 3 7 0 Glutathione S-transferase A1 (EC 2.5.1.18) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed] GSTA1 AOXA P80456 Oryctolagus cuniculus (Rabbit) 3.80184874961636 5.5375 2 2 0 Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) (Retinal oxidase) (Retinoic acid synthase) AOX1 AO CCND3 P30281 Homo sapiens (Human) 5.84569395008697 5.22866319444445 48 169 18.75 G1/S-specific cyclin-D3 CCND3 MK07 Q13164 Homo sapiens (Human) 5.29519356235274 5.36151515151515 11 15 9.09090909090909 Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) MAPK7 BMK1 ERK5 PRKM7 MK10 P53779 Homo sapiens (Human) 4.81943578954329 5.28078504579848 279 385 16.1290322580645 Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) MAPK10 JNK3 JNK3A PRKM10 SAPK1B MK01 P28482 Homo sapiens (Human) 4.44506248431088 5.29407436839859 2457 2701 29.2226292226292 Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) MAPK1 ERK2 PRKM1 PRKM2 CDK15 Q96Q40 Homo sapiens (Human) 5.55375 5.3946875 8 9 0 Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2) CDK15 ALS2CR7 PFTK2 PK3CG P48736 Homo sapiens (Human) 6.02028563200133 5.28552788978495 248 353 0.806451612903226 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K) PIK3CG MAPK5 Q8IW41 Homo sapiens (Human) 3.6385191077189 5.24919658687943 188 245 4.78723404255319 MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) MAPKAPK5 PRAK GP174 Q9BXC1 Homo sapiens (Human) 6.7275 5.20906249999999 8 16 0 Probable G-protein coupled receptor 174 GPR174 FKSG79 GPCR17 GRK7 Q8WTQ7 Homo sapiens (Human) 4.88277163999527 5.23433493589744 65 110 13.8461538461538 Rhodopsin kinase (EC 2.7.11.14) (G protein-coupled receptor kinase 7) (G protein-coupled receptor kinase GRK7) GRK7 GPRK7 P2Y12 Q9EPX4 Rattus norvegicus (Rat) 6.245 4.89375 2 2 0 P2Y purinoceptor 12 (P2Y12) (P2Y12 platelet ADP receptor) P2ry12 P2y12 P2Y10 O00398 Homo sapiens (Human) 7.043125 5.20906249999999 8 16 0 Putative P2Y purinoceptor 10 (P2Y10) (P2Y-like receptor) P2RY10 P2Y11 Q96G91 Homo sapiens (Human) 5.5132009837708 5.090625 12 26 0 P2Y purinoceptor 11 (P2Y11) P2RY11 P2Y14 Q9ESG6 Mus musculus (Mouse) 6.6075 4.984375 4 4 0 P2Y purinoceptor 14 (P2Y14) (G-protein coupled receptor 105) (UDP-glucose receptor) P2ry14 Gpr105 P2Y12 Q9H244 Homo sapiens (Human) 6.75679019969576 5.16625 91 120 0 P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) P2RY12 HORK3 CP2J2 P51589 Homo sapiens (Human) 4.58570821711458 5.60371482075433 7 8 28.5714285714286 Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2) CYP2J2 GPR17 Q13304 Homo sapiens (Human) 4.87666666666667 5.50833333333333 3 4 0 Uracil nucleotide/cysteinyl leukotriene receptor (UDP/CysLT receptor) (G-protein coupled receptor 17) (P2Y-like receptor) (R12) GPR17 PTR1 Q01782 Leishmania major 2.5361420102489 5.461328125 16 16 12.5 Pteridine reductase 1 (EC 1.5.1.33) (H region methotrexate resistance protein) PTR1 HMTXR L1063.01 LmjF23.0270 LmjF_23_0270 SERA O43175 Homo sapiens (Human) 5 4.9375 1 1 0 D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) PHGDH PGDH3 EPHA3 P29320 Homo sapiens (Human) 4.84229986469936 5.23610821759259 72 125 12.5 Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1) EPHA3 ETK ETK1 HEK TYRO4 RGAP1 Q9H0H5 Homo sapiens (Human) 4.25394015900068 5.27256199287882 300 300 20.6666666666667 Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP CHLE P81908 Equus caballus (Horse) 4.71554732145079 5.21031906039497 147 165 6.80272108843537 Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (EQ-BCHE) (Pseudocholinesterase) BCHE ACOD O00767 Homo sapiens (Human) 6.80065208296952 5.21078703703704 27 30 0 Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) (hSCD1) SCD ACOD1 P13516 Mus musculus (Mouse) 7.47989157940379 5.23747707224422 19 19 0 Acyl-CoA desaturase 1 (EC 1.14.19.1) (Delta(9)-desaturase 1) (Delta-9 desaturase 1) (Fatty acid desaturase 1) (Stearoyl-CoA desaturase 1) Scd1 HIPK2 Q9H2X6 Homo sapiens (Human) 4.35407742317633 5.19859375 156 187 5.76923076923077 Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) HIPK2 LUXP P54300 Vibrio harveyi (Beneckea harveyi) 4.575 4.875 2 2 100 Autoinducer 2-binding periplasmic protein LuxP luxP PDK2 Q15119 Homo sapiens (Human) 5.67393733913552 5.32780223004695 71 152 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII) PDK2 PDHK2 1433G P61981 Homo sapiens (Human) 4.37713299523038 5.4659375 10 10 20 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed] YWHAG ARFG1 Q62848 Rattus norvegicus (Rat) 4.63963883784184 5.50642857142857 7 7 14.2857142857143 ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) Arfgap1 Arf1gap UFO P30530 Homo sapiens (Human) 4.32343010192881 5.23042921235105 146 190 5.47945205479452 Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) AXL UFO AAAT Q15758 Homo sapiens (Human) 2.29818636962373 5.31643518518518 9 9 0 Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) SLC1A5 ASCT2 M7V1 RDR RDRC MTAP Q9CQ65 Mus musculus (Mouse) 5.625 5.07 2 2 0 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) Mtap STAT3 P40763 Homo sapiens (Human) 4.51393215813217 5.25832988322717 157 177 61.1464968152866 Signal transducer and activator of transcription 3 (Acute-phase response factor) STAT3 APRF STA5B P51692 Homo sapiens (Human) 4.61092437480818 4.9375 2 2 0 Signal transducer and activator of transcription 5B STAT5B MP2K3 P46734 Homo sapiens (Human) 5.05825625035931 5.28651515151515 11 14 9.09090909090909 Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2) MAP2K3 MEK3 MKK3 PRKMK3 SKK2 NFKB1 P19838 Homo sapiens (Human) 5.205689384784 5.29441099813531 1017 4760 71.3864306784661 Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 CAC1I Q9P0X4 Homo sapiens (Human) 5.73997952248386 5.22366071428571 7 8 0 Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage-gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3) CACNA1I KIAA1120 ABHDB Q8K4F5 Mus musculus (Mouse) 5 5.375 1 1 0 Protein ABHD11 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein homolog) Abhd11 Wbscr21 M3K10 Q02779 Homo sapiens (Human) 5.32325107734316 5.28950980392157 17 20 5.88235294117647 Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) MAP3K10 MLK2 MST AMPB O09175 Rattus norvegicus (Rat) 3.82401358595261 5.27175 5 5 0 Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) Rnpep ACHB P11230 Homo sapiens (Human) 4.10687204922439 5.30179597701149 29 182 0 Acetylcholine receptor subunit beta CHRNB1 ACHRB CHRNB LIPE Q9Y5X9 Homo sapiens (Human) 8.01479602145875 5.42012634408602 93 95 0 Endothelial lipase (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL) LIPG UNQ387/PRO719 SPHK2 Q9NRA0 Homo sapiens (Human) 3.03254847103669 5.43352213541667 32 39 0 Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) SPHK2 CKX2 Q9FUJ3 Arabidopsis thaliana (Mouse-ear cress) 4.68909090909091 5.0744696969697 11 11 9.09090909090909 Cytokinin dehydrogenase 2 (EC 1.5.99.12) (Cytokinin oxidase 2) (AtCKX2) (CKO 2) CKX2 At2g19500 F3P11.10 GRIA2 P23819 Mus musculus (Mouse) 4.4050458197032 5.32439102564103 13 100 0 Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2) Gria2 Glur2 PLK2 Q9NYY3 Homo sapiens (Human) 5.61959535543278 5.16860677083334 48 62 12.5 Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) PLK2 SNK DYR P00374 Homo sapiens (Human) 4.70249638272978 5.32698529411765 51 62 0 Dihydrofolate reductase (EC 1.5.1.3) DHFR PYRF O26232 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) 4.42548158637171 5.25625 4 5 0 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) pyrF MTH_129 NCOA1 Q15788 Homo sapiens (Human) 3.67194863041729 5.28859515182885 138 250 36.9565217391304 Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) NCOA1 BHLHE74 SRC1 PRTN3 Q61096 Mus musculus (Mouse) 4.67 4.8375 1 1 0 Myeloblastin (EC 3.4.21.76) (Proteinase 3) (PR-3) Prtn3 SYT Q8ZDW5 Yersinia pestis 8.41 5.3875 1 1 0 Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) thrS YPO2433 y1903 YP_2221 HSF1 P38532 Mus musculus (Mouse) 4.09537232560387 5.31103895931009 629 754 24.483306836248 Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Hsf1 ADRB2 P07550 Homo sapiens (Human) 4.74345276003786 5.27677545969692 471 709 21.656050955414 Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) ADRB2 ADRB2R B2AR ABC3F Q8IUX4 Homo sapiens (Human) 4.9205734242166 5.2650345036852 1695 2058 25.8997050147493 DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.-) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F) APOBEC3F TNK1 Q13470 Homo sapiens (Human) 4.06318031562421 5.33069791666667 40 62 2.5 Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) TNK1 TTK P33981 Homo sapiens (Human) 5.29310964573218 5.25555555555556 84 119 1.19047619047619 Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) TTK MPS1 MPS1L1 WALK Q45614 Bacillus subtilis (strain 168) 3.04531643228986 5.09 4 4 0 Sensor histidine kinase WalK (EC 2.7.13.3) walK yycG BSU40400 AMD P19021 Homo sapiens (Human) 4.03280951044699 5.54375 2 4 0 Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM PDE8A O60658 Homo sapiens (Human) 4.74911409164439 5.42291666666667 6 8 0 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) PDE8A KITH P04183 Homo sapiens (Human) 4.27023818013992 5.46194444444444 9 11 0 Thymidine kinase, cytosolic (EC 2.7.1.21) TK1 ENPP1 P22413 Homo sapiens (Human) 5.19452089083758 5.4625125 15 25 6.66666666666667 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)] ENPP1 M6S1 NPPS PC1 PDNP1 Q8I2J3 Q8I2J3 Plasmodium falciparum (isolate 3D7) 4.98616442594019 5.38946557971014 46 46 21.7391304347826 M18 aspartyl aminopeptidase (EC 3.4.11.21) PF3D7_0932300 TYDP2 O95551 Homo sapiens (Human) 4.79089860012674 5.41843651330053 38 48 18.4210526315789 Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) TDP2 EAP2 TTRAP AD-022 RIOK1 Q9BRS2 Homo sapiens (Human) 5.17905625098789 5.35076388888889 12 15 8.33333333333333 Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) RIOK1 Q8IEK1 Q8IEK1 Plasmodium falciparum (isolate 3D7) 4.47951247039212 5.2645 70 70 31.4285714285714 M1-family alanyl aminopeptidase (EC 3.4.11.2) PF3D7_1311800 LT4R2 Q9NPC1 Homo sapiens (Human) 4.57389061685878 5.22725925925926 15 58 0 Leukotriene B4 receptor 2 (LTB4-R 2) (LTB4-R2) (LTB4 receptor JULF2) (Leukotriene B4 receptor BLT2) (Seven transmembrane receptor BLTR2) LTB4R2 BLT2R BLTR2 AT1A4 Q13733 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-4) ATP1A4 ATP1AL2 GBRB1 P18505 Homo sapiens (Human) 5.88395557142478 5.24941666666666 65 1117 1.53846153846154 Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) GABRB1 GRIA2 P42262 Homo sapiens (Human) 5.45056426813735 5.28313048245614 38 71 0 Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2) GRIA2 GLUR2 RBBP9 O75884 Homo sapiens (Human) 5.28177747324665 5.18541666666666 2 9 0 Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9) RBBP9 BOG RBBP10 CATB P07858 Homo sapiens (Human) 5.18495714250061 5.2631555690139 186 197 0 Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB CPSB GRIA2 P19491 Rattus norvegicus (Rat) 5.04762319452338 5.28467094017094 195 1025 0 Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2) Gria2 Glur2 5HT3A O70212 Cavia porcellus (Guinea pig) 5.93717590533444 5.24007575757576 11 11 0 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) HTR3A 5HT3R HTR3 ADAM9 Q13443 Homo sapiens (Human) 5.49 5.35 1 1 0 Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) (EC 3.4.24.-) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) ADAM9 KIAA0021 MCMP MDC9 MLTNG S22A3 O88446 Rattus norvegicus (Rat) 2 5.5625 1 1 0 Solute carrier family 22 member 3 (Organic cation transporter 3) Slc22a3 Oct3 S22A3 O75751 Homo sapiens (Human) 3.29376913432653 5.29893937264016 2 2 0 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) SLC22A3 EMTH OCT3 ST38L Q9Y2H1 Homo sapiens (Human) 4.8125 5.3275 8 12 12.5 Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) STK38L KIAA0965 NDR2 BRSK1 Q8TDC3 Homo sapiens (Human) 3.89127659933477 5.23686237373737 165 216 5.45454545454545 Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) BRSK1 KIAA1811 SAD1 SADB KCNB1 P15387 Rattus norvegicus (Rat) 5.62 5.02499999999999 1 1 0 Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1) Kcnb1 PA2 P00630 Apis mellifera (Honeybee) 4.69537280771112 5.52583333333333 2 2 0 Phospholipase A2 (bvPLA2) (EC 3.1.1.4) (Allergen Api m I) (Phosphatidylcholine 2-acylhydrolase) (allergen Api m 1) F16P1 P00636 Sus scrofa (Pig) 3.84106425738645 5.07321428571429 7 7 0 Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) FBP1 FBP ADCY4 Q8NFM4 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) ADCY4 TESK2 Q96S53 Homo sapiens (Human) 4.86858583018689 5.075 3 3 0 Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) TESK2 SCN2A Q99250 Homo sapiens (Human) 4.92076065635361 5.17388773975597 33 125 9.09090909090909 Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) SCN2A NAC2 SCN2A1 SCN2A2 SCN3A Q9NY46 Homo sapiens (Human) 4.88731710362962 5.21697770815181 26 109 11.5384615384615 Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) SCN3A KIAA1356 NAC3 IMDH1 P20839 Homo sapiens (Human) 5.81766405958817 5.18186342592593 18 39 5.55555555555556 Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I) IMPDH1 IMPD1 SETB1 Q15047 Homo sapiens (Human) 5.66 5.35 1 2 0 Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) SETDB1 KIAA0067 KMT1E KMT5A Q9NQR1 Homo sapiens (Human) 4.76666666666667 5.25916666666667 3 3 0 N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 SUV91 O43463 Homo sapiens (Human) 4.98816166738934 5.21666666666667 3 10 0 Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) SUV39H1 KMT1A SUV39H SUV92 Q9H5I1 Homo sapiens (Human) 4.575 5.1775 2 4 0 Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 KMT1B XPP2 O43895 Homo sapiens (Human) 4.9692059991328 5.2725 5 9 0 Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2) XPNPEP2 KCNJ9 Q92806 Homo sapiens (Human) 2 4.8275 1 2 0 G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9) KCNJ9 GIRK3 SKN1 P34707 Caenorhabditis elegans 3.76431774817149 5.32436010194308 348 502 45.1149425287356 Protein skinhead-1 skn-1 T19E7.2 NOX4 Q9NPH5 Homo sapiens (Human) 5.96937038962765 5.29333333333333 11 14 9.09090909090909 NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) NOX4 RENOX CISD1 Q9NZ45 Homo sapiens (Human) 4.295 5.1175 4 4 25 CDGSH iron-sulfur domain-containing protein 1 (MitoNEET) CISD1 C10orf70 ZCD1 MDS029 OXDA P14920 Homo sapiens (Human) 5.71865258907275 5.29753333333333 25 26 0 D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO DAMOX KCC2A Q9UQM7 Homo sapiens (Human) 3.83489985152116 5.2221135836063 144 270 0.694444444444444 Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) CAMK2A CAMKA KIAA0968 KCNH2 O08703 Cavia porcellus (Guinea pig) 6.4 5.51 1 1 0 Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (gp-erg) (Voltage-gated potassium channel subunit Kv11.1) (Fragment) KCNH2 ERG SENP8 Q96LD8 Homo sapiens (Human) 4.63796956112525 5.2312235373395 343 419 42.5655976676385 Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8) SENP8 DEN1 NEDP1 PRSC2 FKSG8 ATAD5 Q96QE3 Homo sapiens (Human) 4.99753994051739 5.26134470173083 17522 25735 39.6244720922269 ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) ATAD5 C17orf41 FRAG1 LPAR2 Q9HBW0 Homo sapiens (Human) 5.64992034642082 5.13083333333333 6 9 0 Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) LPAR2 EDG4 LPA2 LPAR3 Q9UBY5 Homo sapiens (Human) 5.52447408083486 5.248 10 14 0 Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7) LPAR3 EDG7 LPA3 GSP P90518 Crithidia fasciculata 4.90664564834008 5.43125 4 10 0 Glutathionylspermidine synthase (EC 6.3.1.8) GSP HDA11 Q96DB2 Homo sapiens (Human) 5.59525984149233 5.32266870274824 219 3695 0.91324200913242 Histone deacetylase 11 (HD11) (EC 3.5.1.98) HDAC11 LPAR1 Q92633 Homo sapiens (Human) 5.74597808253064 5.25464285714286 7 9 0 Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) LPAR1 EDG2 LPA1 KCNQ4 P56696 Homo sapiens (Human) 4.93558452583209 5 1 2 0 Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4) KCNQ4 KCC2G Q13555 Homo sapiens (Human) 4.0679203519836 5.16682765151515 154 269 6.49350649350649 Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) CAMK2G CAMK CAMK-II CAMKG EYA2 O00167 Homo sapiens (Human) 4.30560630846691 5.2900067038343 770 774 13.2467532467532 Eyes absent homolog 2 (EC 3.1.3.48) EYA2 EAB1 BXB P10844 Clostridium botulinum 4 4.8125 1 1 0 Botulinum neurotoxin type B (BoNT/B) (EC 3.4.24.69) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain; Botulinum neurotoxin B heavy chain] botB MIF P14174 Homo sapiens (Human) 4.9203666930866 5.20072485632184 58 110 1.72413793103448 Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF GLIF MMIF ADCY9 O60503 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9) ADCY9 KIAA0520 COQ8B Q96D53 Homo sapiens (Human) 4.87768563304579 5.32241666666667 10 14 10 Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B) COQ8B ADCK4 Q79MP6 Q79MP6 Pseudomonas aeruginosa 4.45367601480898 5.32004034868058 46 75 2.17391304347826 Beta-lactamase (EC 3.5.2.6) blaIMP-1 bla IMP bla-imp blaESP imp LMNA P02545 Homo sapiens (Human) 5.36772668134491 5.31417627826413 4527 4592 37.1990280538988 Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] LMNA LMN1 GRM3 Q14832 Homo sapiens (Human) 4.76169483343228 5.36072916666667 36 63 8.33333333333333 Metabotropic glutamate receptor 3 (mGluR3) GRM3 GPRC1C MGLUR3 TNNC1 P63316 Homo sapiens (Human) 4.62783757783353 5.38527546296296 30 90 43.3333333333333 Troponin C, slow skeletal and cardiac muscles (TN-C) TNNC1 TNNC CYSP P25779 Trypanosoma cruzi 4.64847924994505 5.37987523320898 2999 3281 44.9816605535178 Cruzipain (EC 3.4.22.51) (Cruzaine) (Major cysteine proteinase) CATL1 P07711 Homo sapiens (Human) 5.23570579746831 5.27424347643098 198 209 5.55555555555556 Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] CTSL CTSL1 DDHD1 Q80YA3 Mus musculus (Mouse) 5 5.375 1 1 0 Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) Ddhd1 SO1B3 Q9NPD5 Homo sapiens (Human) 5.8355989693937 5.30249715457365 117 129 17.9487179487179 Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8) SLCO1B3 LST2 OATP1B3 OATP8 SLC21A8 ANPRC P17342 Homo sapiens (Human) 5.84858583018689 5.18333333333333 3 5 0 Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) NPR3 ANPRC C5orf23 NPRC SO1A5 O88397 Rattus norvegicus (Rat) 4.51352849594721 4.975 2 2 0 Solute carrier organic anion transporter family member 1A5 (Organic anion-transporting polypeptide 3) (OATP-3) (Sodium-independent organic anion transporter 3) (Solute carrier family 21 member 7) Slco1a5 Oatp1a5 Oatp3 Slc21a7 Slco1a2 SO1A3 P70502 Rattus norvegicus (Rat) 3.90806507002482 6.1125 2 3 50 Solute carrier organic anion transporter family member 1A3 (OAT-K2) (Sodium-independent organic anion transporter K1) (OAT-K1) (Solute carrier family 21 member 4) (rOAT-K) Slco1a3 Oatp1a3 Slc21a4 PANK1 Q8TE04 Homo sapiens (Human) 6.12 5.09666666666667 4 5 0 Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) PANK1 PANK PANK3 Q9H999 Homo sapiens (Human) 5.42 5.09416666666667 3 3 0 Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) PANK3 AURKC Q9UQB9 Homo sapiens (Human) 4.8451038701825 5.24248706896552 87 145 11.4942528735632 Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) AURKC AIE2 AIK3 AIRK3 ARK3 STK13 NR4A1 P22736 Homo sapiens (Human) 4.261628749458 5.54325520833333 40 40 25 Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) NR4A1 GFRP1 HMR NAK1 COQ8A Q8NI60 Homo sapiens (Human) 5.21681910223576 5.29174242424242 11 14 9.09090909090909 Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3) COQ8A ADCK3 CABC1 PP265 RUVB1 Q9Y265 Homo sapiens (Human) 2 5.4875 1 1 0 RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha) RUVBL1 INO80H NMP238 TIP49 TIP49A CCNA2 P20248 Homo sapiens (Human) 5.84872488124546 5.24292447099065 244 854 4.50819672131148 Cyclin-A2 (Cyclin-A) (Cyclin A) CCNA2 CCN1 CCNA KTHY P9WKE1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.35563371173727 5.41323214285714 14 15 0 Thymidylate kinase (EC 2.7.4.9) (Thymidine monophosphate kinase) (dTMP kinase) (TMPK) tmk Rv3247c KPCL P24723 Homo sapiens (Human) 5.36605289951386 5.29388053709401 154 920 6.49350649350649 Protein kinase C eta type (EC 2.7.11.13) (PKC-L) (nPKC-eta) PRKCH PKCL PRKCL MED23 Q9ULK4 Homo sapiens (Human) 2 4.925 1 2 0 Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2 SGK3 Q96BR1 Homo sapiens (Human) 4.58932779928638 5.24276348039216 68 110 10.2941176470588 Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) SGK3 CISK SGKL SGK2 Q9HBY8 Homo sapiens (Human) 3.85285591009559 5.24494785429142 167 208 4.79041916167665 Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2) SGK2 M4K2 Q12851 Homo sapiens (Human) 4.33723086944142 5.27027834615785 211 267 4.2654028436019 Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) MAP4K2 GCK RAB8IP SCAF P16753 Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) 6.12557079757135 5.12368055555556 21 26 0 Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) (Protease); Assembly protein (Capsid assembly protein)] UL80 APNG HISX Q8G2R2 Brucella suis biovar 1 (strain 1330) 7.13 5.51354166666667 3 5 0 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) hisD BR0252 BS1330_I0253 ADA10 O14672 Homo sapiens (Human) 5.9325641025641 5.566375 13 19 0 Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) ADAM10 KUZ MADM TF7L2 Q9NQB0 Homo sapiens (Human) 5.87 5.3 1 2 0 Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) TCF7L2 TCF4 AHR P41738 Rattus norvegicus (Rat) 7.885 4.9 1 2 0 Aryl hydrocarbon receptor (Ah receptor) (AhR) Ahr AHR P30561 Mus musculus (Mouse) 3.49919180253992 5.43361111111111 9 10 0 Aryl hydrocarbon receptor (Ah receptor) (AhR) Ahr M4K4 O95819 Homo sapiens (Human) 4.86310746316521 5.23951126662256 226 258 0.442477876106195 Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) MAP4K4 HGK KIAA0687 NIK M4K1 Q92918 Homo sapiens (Human) 5.26716502298173 5.291875 12 15 8.33333333333333 Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) MAP4K1 HPK1 TBB5 P07437 Homo sapiens (Human) 5.01184557933934 5.18027827380952 70 1489 0 Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 OK/SW-cl.56 NPY2R P49146 Homo sapiens (Human) 4.26636017533208 5.14082541213071 183 273 20.2185792349727 Neuropeptide Y receptor type 2 (NPY2-R) (NPY-Y2 receptor) (Y2 receptor) NPY2R UD19 O60656 Homo sapiens (Human) 3.97575378227885 5.30625 5 7 20 UDP-glucuronosyltransferase 1-9 (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (UDP-glucuronosyltransferase 1A9) (lugP4) UGT1A9 GNT1 UGT1 UD110 Q9HAW8 Homo sapiens (Human) 3.0982435303913 5.59375 2 3 50 UDP-glucuronosyltransferase 1-10 (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) (UDP-glucuronosyltransferase 1A10) UGT1A10 GNT1 UGT1 UD18 Q9HAW9 Homo sapiens (Human) 3.41567671165697 5.4125 3 3 33.3333333333333 UDP-glucuronosyltransferase 1-8 (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) (UDP-glucuronosyltransferase 1A8) UGT1A8 GNT1 UGT1 HCN2 O88703 Mus musculus (Mouse) 4.685 4.97499999999999 2 2 0 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1) Hcn2 Bcng2 Hac1 HCN1 O88704 Mus musculus (Mouse) 5.16833317484312 4.97499999999999 2 4 0 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2) Hcn1 Bcng1 Hac2 PIM3 O70444 Rattus norvegicus (Rat) 8.05 5.235 5 10 0 Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (Kinase induced by depolarization) (Protein kinase Kid-1) Pim3 Kid1 TNIK Q9UKE5 Homo sapiens (Human) 6.07458549833746 5.44796052631579 19 25 5.26315789473684 TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) TNIK KIAA0551 UD16 P19224 Homo sapiens (Human) 3.28431811792051 4.96875000000001 2 2 0 UDP-glucuronosyltransferase 1-6 (UDPGT 1-6) (UGT1*6) (UGT1-06) (UGT1.6) (EC 2.4.1.17) (Phenol-metabolizing UDP-glucuronosyltransferase) (UDP-glucuronosyltransferase 1-F) (UGT-1F) (UGT1F) (UDP-glucuronosyltransferase 1A6) UGT1A6 GNT1 UGT1 MRCKA Q5VT25 Homo sapiens (Human) 3.70306141430403 5.25231174698795 166 196 3.6144578313253 Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) CDC42BPA KIAA0451 UD17 Q9HAW7 Homo sapiens (Human) 4.50021725588701 5.675 2 2 50 UDP-glucuronosyltransferase 1-7 (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) (UDP-glucuronosyltransferase 1A7) UGT1A7 GNT1 UGT1 NANP Q8TBE9 Homo sapiens (Human) 4 5.375 1 1 0 N-acylneuraminate-9-phosphatase (EC 3.1.3.29) (Haloacid dehalogenase-like hydrolase domain-containing protein 4) (Neu5Ac-9-Pase) NANP C20orf147 HDHD4 MKNK1 Q9BUB5 Homo sapiens (Human) 4.76640939630258 5.26296875 74 108 5.40540540540541 MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) MKNK1 MNK1 TSSK2 Q96PF2 Homo sapiens (Human) 3.29511134778269 5.25629855889725 133 179 5.26315789473684 Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B) TSSK2 DGSG SPOGA2 STK22B DHI2 P51661 Mus musculus (Mouse) 5.39794000867204 4.8875 1 1 0 Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) Hsd11b2 Hsd11k DHI2 P80365 Homo sapiens (Human) 3.99350942293665 5.14188095238095 35 40 0 Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (11-beta-HSD) (Short chain dehydrogenase/reductase family 9C member 3) HSD11B2 HSD11K SDR9C3 ANKK1 Q8NFD2 Homo sapiens (Human) 5.09444444444445 5.36768518518518 9 12 11.1111111111111 Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 CAH15 Q99N23 Mus musculus (Mouse) 5.17377209708045 5.02916666666667 6 6 33.3333333333333 Carbonic anhydrase 15 (EC 4.2.1.1) (Carbonate dehydratase XV) (Carbonic anhydrase XV) (CA-XV) Ca15 Car15 CAH13 Q9D6N1 Mus musculus (Mouse) 5.56595224101375 5.26185185185185 9 10 11.1111111111111 Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) Ca13 Car13 HRH1 P70174 Mus musculus (Mouse) 5.63202321470541 5.115 1 1 0 Histamine H1 receptor (H1R) (HH1R) Hrh1 Bphs CATS P25774 Homo sapiens (Human) 6.72707917719807 5.23931672494172 143 178 0 Cathepsin S (EC 3.4.22.27) CTSS TGT P28720 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) 3.87190032645213 5.346875 2 2 0 Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) tgt ZMO0363 PPME1 Q8BVQ5 Mus musculus (Mouse) 5 5.375 1 1 0 Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Ppme1 Pme1 HDAC7 Q99P96 Rattus norvegicus (Rat) 5.32433877356746 5.17291666666667 2 28 0 Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Fragment) Hdac7 Hdac7a KAT5 Q92993 Homo sapiens (Human) 5.1251505876423 4.8875 1 8 0 Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (cPLA(2)-interacting protein) KAT5 HTATIP TIP60 KC1A P48729 Homo sapiens (Human) 3.68096043945313 5.26064422827531 213 264 0.938967136150235 Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) CSNK1A1 AMP1 O96935 Plasmodium falciparum (isolate FcB1 / Columbia) 5.50596130596099 5.26590909090909 11 12 0 M1 family aminopeptidase (EC 3.4.11.-) (Pfa-M1) EDNRA Q61614 Mus musculus (Mouse) 8.0625 5.10625 4 4 0 Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) Ednra Gpcr10 DRD1 Q61616 Mus musculus (Mouse) 4.34242268082221 4.85 1 5 0 D(1A) dopamine receptor (Dopamine D1 receptor) Drd1 Drd1a Gpcr15 KPCD Q05655 Homo sapiens (Human) 4.76050048036947 5.2743866411488 261 998 2.68199233716475 Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] PRKCD FSHR P23945 Homo sapiens (Human) 5.35304492190568 5.425 9 20 0 Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) FSHR LGR1 DPP2 Q9ET22 Mus musculus (Mouse) 5 5.375 1 1 0 Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) Dpp7 Dpp2 Qpp EGLN2 Q96KS0 Homo sapiens (Human) 7.18828787452803 5.35395833333333 10 10 0 Egl nine homolog 2 (EC 1.14.11.29) (Estrogen-induced tag 6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1) EGLN2 EIT6 EGLN1 Q9GZT9 Homo sapiens (Human) 5.33166160882614 5.28919564198688 97 117 2.06185567010309 Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) EGLN1 C1orf12 PNAS-118 PNAS-137 EGLN3 Q9H6Z9 Homo sapiens (Human) 6.89528787452803 5.26675 10 12 0 Egl nine homolog 3 (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3) EGLN3 P4HTM Q9NXG6 Homo sapiens (Human) 5.36701147726319 5.39403017241379 29 32 0 Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4HTM PH4 RPGF4 Q8WZA2 Homo sapiens (Human) 4.37407243112583 5.26488728094565 1153 1229 17.2593235039029 Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 RPGF4 Q9EQZ6 Mus musculus (Mouse) 3.425 4.975 2 2 0 Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) Rapgef4 Cgef2 Epac2 ANM5 O14744 Homo sapiens (Human) 4.30102999566398 5.35 1 1 0 Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] PRMT5 HRMT1L5 IBP72 JBP1 SKB1 E2AK1 Q9BQI3 Homo sapiens (Human) 5 5.37208333333333 6 6 0 Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Hemin-sensitive initiation factor 2-alpha kinase) EIF2AK1 HRI KIAA1369 PRO1362 NCOA3 Q9Y6Q9 Homo sapiens (Human) 3.9919463005677 5.27797231304494 142 258 38.7323943661972 Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) NCOA3 AIB1 BHLHE42 RAC3 TRAM1 ANM1 Q99873 Homo sapiens (Human) 4.133608122258 5.34762019230769 26 42 0 Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) PRMT1 HMT2 HRMT1L2 IR1B4 EPAS1 Q99814 Homo sapiens (Human) 5.422 5.396625 10 12 0 Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2) EPAS1 BHLHE73 HIF2A MOP2 PASD2 CTRO O14578 Homo sapiens (Human) 5.0575 5.3275 8 11 12.5 Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 EPHA2 P29317 Homo sapiens (Human) 3.61952183581626 5.22321875 180 219 5 Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) EPHA2 ECK PCP Q7TMR0 Mus musculus (Mouse) 5 5.375 1 1 0 Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) Prcp PKR1 Q8TCW9 Homo sapiens (Human) 5.65131370402551 5.23020833333333 3 5 0 Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a) PROKR1 GPR73 PKR1 PBPB P02919 Escherichia coli (strain K12) 3.51851393987789 5.125 1 2 0 Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] mrcB pbpF ponB b0149 JW0145 PTPRC P08575 Homo sapiens (Human) 2.68525109944239 5.29408861844958 114 204 22.8070175438596 Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 DGAT1 O75907 Homo sapiens (Human) 6.7029765603862 5.28682745691524 58 68 0 Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) DGAT1 AGRP1 DGAT PGFRB Q05030 Rattus norvegicus (Rat) 5.615 5.14239583333333 6 6 0 Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) Pdgfrb Pdgfr Pdgfr1 SOAT1 P35610 Homo sapiens (Human) 4.91122986779136 5.19695945945946 37 42 0 Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT PTN11 Q06124 Homo sapiens (Human) 4.48381985604787 5.30841177983539 81 86 12.3456790123457 Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) PTPN11 PTP2C SHPTP2 NMDZ1 P35439 Rattus norvegicus (Rat) 5.32422524648746 5.36834521626106 522 4586 0.383141762452107 Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) Grin1 Nmdar1 PMYT1 Q99640 Homo sapiens (Human) 4.83333333333333 5.30944444444444 9 13 11.1111111111111 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) PKMYT1 MYT1 BLK P51451 Homo sapiens (Human) 4.04219532379959 5.25652284946237 155 204 5.80645161290323 Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) BLK TLK1 Q9UKI8 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) TLK1 KIAA0137 GPR55 Q9Y2T6 Homo sapiens (Human) 4.78464891435535 5.30419270833333 56 70 17.8571428571429 G-protein coupled receptor 55 GPR55 MCHR1 P97639 Rattus norvegicus (Rat) 8.395 5.7 1 2 0 Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) Mchr1 Gpr24 Slc1 KAPCG P22612 Homo sapiens (Human) 4.73391696606124 5.2003231292517 98 312 3.06122448979592 cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) PRKACG GNAI1 P63096 Homo sapiens (Human) 3.0847187649769 5.085125 5 5 20 Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) GNAI1 FABH Q820T1 Enterococcus faecalis (strain ATCC 700802 / V583) 4.2425 5.09192708333334 4 5 0 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthase III) (Beta-ketoacyl-ACP synthase III) (KAS III) fabH EF_2885 MCHR2 Q969V1 Homo sapiens (Human) 6.32916666666667 5.68791666666667 8 17 0 Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCH-R2) (MCHR-2) (G-protein coupled receptor 145) (GPRv17) (MCH-2R) (MCH2) (MCH2R) MCHR2 GPR145 SLT SCN8A Q9UQD0 Homo sapiens (Human) 3.72 5.16768937264017 2 11 0 Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) SCN8A MED SCN8A Q9WTU3 Mus musculus (Mouse) 5.6850612633917 4.95 2 2 0 Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) Scn8a Nbna1 BMP2K Q9NSY1 Homo sapiens (Human) 5.27022754705341 5.30480769230769 13 17 7.69230769230769 BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) BMP2K BIKE HRIHFB2017 PDE8B O95263 Homo sapiens (Human) 6.48396962855041 5.28462463300945 20 22 0 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) PDE8B PIG22 EPHA4 Q03137 Mus musculus (Mouse) 4.55251499783199 5.2285 5 10 20 Ephrin type-A receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor MPK-3) (Tyrosine-protein kinase receptor SEK-1) Epha4 Sek Sek1 Q7T1G6 Q7T1G6 Danio rerio (Zebrafish) (Brachydanio rerio) 4.63569968445236 5.39276234567901 27 28 22.2222222222222 Ion channel NompC trpn1 nompc HIPK1 Q86Z02 Homo sapiens (Human) 4.86269641596247 5.26064644607843 68 99 10.2941176470588 Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2) HIPK1 KIAA0630 MYAK NBAK2 GRP3 Q8IV61 Homo sapiens (Human) 7.34428571428571 5.79964285714286 7 10 0 Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) RASGRP3 GRP3 KIAA0846 PDE4D Q08499 Homo sapiens (Human) 5.51586628645745 5.27961071307661 236 891 0.423728813559322 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) PDE4D DPDE3 BLAT P62593 Escherichia coli 6.10772303594059 5.39458333333333 28 36 0 Beta-lactamase TEM (EC 3.5.2.6) (IRT-4) (Penicillinase) (TEM-1) (TEM-16/CAZ-7) (TEM-2) (TEM-24/CAZ-6) (TEM-3) (TEM-4) (TEM-5) (TEM-6) (TEM-8/CAZ-2) bla; blaT-3; blaT-4; blaT-5; blaT-6 COMT P22734 Rattus norvegicus (Rat) 4.20474587010996 5.39127840909091 22 39 0 Catechol O-methyltransferase (EC 2.1.1.6) Comt VACHT P81721 Tetronarce californica (Pacific electric ray) (Torpedo californica) 7.27166666666667 4.97583333333333 3 4 0 Vesicular acetylcholine transporter (VAChT) (TorVAChT) CD11B P21127 Homo sapiens (Human) 5.07111111111111 5.36768518518518 9 12 11.1111111111111 Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) CDK11B CDC2L1 CDK11 PITSLREA PK58 VMAT2 Q01827 Rattus norvegicus (Rat) 6.05535403002096 5.22857142857143 7 13 0 Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) Slc18a2 Svat Vmat2 APH1A Q96BI3 Homo sapiens (Human) 4.97578556722111 5.14483913502109 79 912 0 Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor) APH1A PSF CGI-78 UNQ579/PRO1141 PEN2 Q9NZ42 Homo sapiens (Human) 4.97638345445021 5.13848508230452 81 916 0 Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) PSENEN PEN2 MDS033 5HT3A P46098 Homo sapiens (Human) 6.1611737735701 5.34117299578059 79 255 0 5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor) HTR3A 5HT3R HTR3 IMDH2 P24547 Mus musculus (Mouse) 2.84948500216801 5.01875 2 2 0 Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II) Impdh2 C3AR Q16581 Homo sapiens (Human) 5.76725 5.21999999999999 4 11 0 C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) C3AR1 AZ3B C3R1 HNFAG09 Q9BPW0 Q9BPW0 Homo sapiens (Human) 3.84187749721366 5.44618055555556 18 18 22.2222222222222 Serine/threonine-protein phosphatase (EC 3.1.3.16) (Fragment) PPP5C KS6A5 O75582 Homo sapiens (Human) 4.29703694034135 5.2307426597582 193 514 4.14507772020725 Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) RPS6KA5 MSK1 KS6A4 O75676 Homo sapiens (Human) 4.67454758483106 5.25577991452992 78 282 11.5384615384615 Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) RPS6KA4 MSK2 SGPL1 O95470 Homo sapiens (Human) 5.47 5.0875 1 1 0 Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) SGPL1 KIAA1252 CHIA Q91XA9 Mus musculus (Mouse) 4.05 5.3625 1 1 0 Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (YNL) Chia Chia1 CHIA Q9BZP6 Homo sapiens (Human) 4.66 4.94166666666667 1 1 0 Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA SCRB1 Q8WTV0 Homo sapiens (Human) 8.14 5.16611111111111 3 3 0 Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) SCARB1 CD36L1 CLA1 CEGT O88693 Mus musculus (Mouse) 3.962963169357 5.3072265625 8 13 0 Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) Ugcg KDM2A Q9Y2K7 Homo sapiens (Human) 5.15235345981649 5.39447916666667 14 32 0 Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) KDM2A CXXC8 FBL7 FBXL11 JHDM1A KIAA1004 KCND2 Q63881 Rattus norvegicus (Rat) 4.96 5.02499999999999 1 1 0 Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2) Kcnd2 RL3R2 Q8TDU9 Homo sapiens (Human) 7.85 4.95 1 1 0 Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (G-protein coupled receptor GPCR142) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4) RXFP4 GPR100 RLN3R2 TAAR1 Q923Y9 Rattus norvegicus (Rat) 8.54166666666667 5.44166666666667 6 6 0 Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) Taar1 Ta1 Tar1 Trar1 SIR2 Q8IXJ6 Homo sapiens (Human) 4.68681186376168 5.2780787037037 126 151 4.76190476190476 NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) SIRT2 SIR2L SIR2L2 SIR6 Q8N6T7 Homo sapiens (Human) 3.5 4.91041666666666 2 2 0 NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) SIRT6 SIR2L6 TAAR1 Q923Y8 Mus musculus (Mouse) 8.6048125 5.49131536458333 160 161 0 Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) Taar1 Ta1 Tar1 Trar1 SIR1 Q96EB6 Homo sapiens (Human) 4.65509021920505 5.24385532407407 120 164 3.33333333333333 NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] SIRT1 SIR2L1 SIR7 Q9NRC8 Homo sapiens (Human) 2 4.87083333333333 1 1 0 NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) SIRT7 SIR2L7 SIR3 Q9NTG7 Homo sapiens (Human) 5.00768989406771 5.18497474747475 33 35 3.03030303030303 NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) SIRT3 SIR2L3 SIR4 Q9Y6E7 Homo sapiens (Human) 2 4.87083333333333 1 1 0 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 3.5.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4) SIRT4 SIR2L4 PSA5 P28066 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain) PSMA5 PRKDC P78527 Homo sapiens (Human) 6.05817361780976 5.25654405737705 122 152 1.63934426229508 DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) PRKDC HYRC HYRC1 PI4KB Q9UBF8 Homo sapiens (Human) 4.89116086150034 5.29576041666667 120 289 0 Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) PI4KB PIK4CB GSK3B P49841 Homo sapiens (Human) 5.46016753441551 5.2417614682648 698 930 2.29226361031519 Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) GSK3B SIK2 Q9H0K1 Homo sapiens (Human) 4.41147791817135 5.22686125 50 76 2 Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) SIK2 KIAA0781 QIK SNF1LK2 ABD12 Q8N2K0 Homo sapiens (Human) 2 5.22979166666667 6 6 0 Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 12) ABHD12 C20orf22 HCN4 Q9Y3Q4 Homo sapiens (Human) 5.12506154164687 4.97499999999999 2 4 0 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 MTNN P0AF12 Escherichia coli (strain K12) 7.695 5.0375 2 2 0 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTA/SAH nucleosidase) (MTAN) (EC 3.2.2.9) (5'-methylthioadenosine nucleosidase) (MTA nucleosidase) (P46) (S-adenosylhomocysteine nucleosidase) (AdoHcy nucleosidase) (SAH nucleosidase) (SRH nucleosidase) mtnN mtn pfs yadA b0159 JW0155 3MG1 P05100 Escherichia coli (strain K12) 6.02 5.43291666666666 2 2 0 DNA-3-methyladenine glycosylase 1 (EC 3.2.2.20) (3-methyladenine-DNA glycosylase I, constitutive) (TAG I) (DNA-3-methyladenine glycosidase I) (DNA-3-methyladenine glycosylase I) tag b3549 JW3518 ARK73 P38918 Rattus norvegicus (Rat) 3.96961354416741 4.85 1 3 0 Aflatoxin B1 aldehyde reductase member 3 (AFB1-AR) (EC 1.-.-.-) (Aflatoxin B1 aldehyde reductase member 1) (rAFAR1) Akr7a3 Afar Akr7a1 MKNK2 Q9HBH9 Homo sapiens (Human) 4.57364811605776 5.24546306818182 198 254 4.04040404040404 MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) MKNK2 GPRK7 MNK2 MITF O75030 Homo sapiens (Human) 5.29126261184799 5.53770320457502 110 370 39.0909090909091 Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) MITF BHLHE32 PLEC Q15149 Homo sapiens (Human) 3.74868814470828 5.2908487654321 18 54 16.6666666666667 Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 PNMT P11086 Homo sapiens (Human) 5.68558763663958 5.27237471158015 26 37 0 Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28) (Noradrenaline N-methyltransferase) PNMT PENT ADA P56658 Bos taurus (Bovine) 5.09529686425372 5.33187859195402 58 62 0 Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) ADA PA1L Q05097 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 6.75 4.95 1 1 0 PA-I galactophilic lectin (PA-IL) (Galactose-binding lectin) lecA pa1L PA2570 Q59401 Q59401 Enterobacter cloacae 5.904 5.30625 5 6 0 Beta-lactamase (EC 3.5.2.6) ACTB O93400 Xenopus laevis (African clawed frog) 6.13 4.95 4 4 0 Actin, cytoplasmic 1 (Beta-actin) (Cytoplasmic beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] actb CAH2 P00921 Bos taurus (Bovine) 5.81805739467289 5.56416666666667 13 142 0 Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) CA2 VPS4B O75351 Homo sapiens (Human) 2 5.5 1 1 0 Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 MPP8 Q99549 Homo sapiens (Human) 4.95087341405168 5.30138287457749 79 94 44.3037974683544 M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 MBNL1 Q9NR56 Homo sapiens (Human) 4.88561717993477 5.29508471737386 5043 5074 29.0303390838786 Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) MBNL1 EXP KIAA0428 MBNL CRK P46108 Homo sapiens (Human) 2 5.5125 1 1 0 Adapter molecule crk (Proto-oncogene c-Crk) (p38) CRK PPCE P48147 Homo sapiens (Human) 4.96059160605699 5.21808986928105 51 78 1.96078431372549 Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP PEP WNK2 Q9Y3S1 Homo sapiens (Human) 5.76277626762614 5.12286111111111 30 45 26.6666666666667 Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) WNK2 KIAA1760 PRKWNK2 SDCCAG43 P/OKcl.13 CNOT7 Q9UIV1 Homo sapiens (Human) 4.795 4.98359375 4 4 0 CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a) CNOT7 CAF1 ROCK2 O75116 Homo sapiens (Human) 5.59914006617647 5.22995514266599 368 477 2.17391304347826 Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) ROCK2 KIAA0619 IL2 P60568 Homo sapiens (Human) 5.26 4.95 1 1 100 Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin) IL2 LEF P15917 Bacillus anthracis 5.10652571427774 5.35629573742271 911 942 30.2963776070252 Lethal factor (LF) (EC 3.4.24.83) (Anthrax lethal toxin endopeptidase component) lef pXO1-107 BXA0172 GBAA_pXO1_0172 KIF11 P52732 Homo sapiens (Human) 5.64386111285827 5.23186070261438 102 118 0.980392156862745 Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) KIF11 EG5 KNSL1 TRIP5 TYPH P19971 Homo sapiens (Human) 4.75580020788037 5.26278409090909 44 75 0 Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase) TYMP ECGF1 SAE1 Q9UBE0 Homo sapiens (Human) 4.72198133470603 5.1705505952381 42 124 26.1904761904762 SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] SAE1 AOS1 SUA1 UBLE1A ISPT Q97SR4 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 6.26428571428571 5.42172619047619 7 7 0 Isoprenyl transferase (EC 2.5.1.-) uppS SP_0261 MET P08581 Homo sapiens (Human) 5.21012525954876 5.28535865744739 520 700 1.15384615384615 Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET M3K3 Q99759 Homo sapiens (Human) 5.52 5.438125 8 9 0 Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) MAP3K3 MAPKKK3 MEKK3 ABC3G Q9HC16 Homo sapiens (Human) 4.97653822548899 5.29185030967112 1354 1725 30.0590841949778 DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.-) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G) APOBEC3G MDS019 PAG15 Q8VEB4 Mus musculus (Mouse) 5 5.375 1 1 0 Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) Pla2g15 Lypla3 PLPP P60487 Mus musculus (Mouse) 3.8068638918593 5.5 2 10 0 Pyridoxal phosphate phosphatase (PLP phosphatase) (EC 3.1.3.3) (EC 3.1.3.74) (Chronophin) Pdxp Cin Plp Plpp SMS2 Q8NHU3 Homo sapiens (Human) 3.67666666666667 5.32 3 3 0 Phosphatidylcholine:ceramide cholinephosphotransferase 2 (EC 2.7.8.27) (Sphingomyelin synthase 2) SGMS2 SMS2 IF4H Q15056 Homo sapiens (Human) 4.2546875 5.31351101572662 32 34 6.25 Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) EIF4H KIAA0038 WBSCR1 WSCR1 Q6QLK5 Q6QLK5 Human immunodeficiency virus 1 4.73974385479102 5.14287878787879 22 22 27.2727272727273 Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM)] env TAOK1 Q7L7X3 Homo sapiens (Human) 3.76876073461327 5.23426587813551 172 196 5.23255813953488 Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) TAOK1 KIAA1361 MAP3K16 MARKK DPOLA P26019 Drosophila melanogaster (Fruit fly) 3.69897000433602 5.1 1 1 0 DNA polymerase alpha catalytic subunit (EC 2.7.7.7) DNApol-alpha180 DNApol-alpha POLA CG6349 MA1A1 P53624 Drosophila melanogaster (Fruit fly) 4.04575749056067 5.04583333333333 3 3 0 Mannosyl-oligosaccharide alpha-1,2-mannosidase IA (EC 3.2.1.113) (Man(9)-alpha-mannosidase) (Mannosidase-1) alpha-Man-Ia alpha-man-1 mas-1 CG32684 SYM P00959 Escherichia coli (strain K12) 5.38855657627854 5.18229166666667 6 6 0 Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) metG b2114 JW2101 PUR9 P31939 Homo sapiens (Human) 3.83720448296449 5.2300625 10 12 20 Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] ATIC PURH OK/SW-cl.86 ACES P21836 Mus musculus (Mouse) 5.18115017665149 5.56284722222222 9 12 0 Acetylcholinesterase (AChE) (EC 3.1.1.7) Ache PABP1 P11940 Homo sapiens (Human) 4.09148064158228 5.34066248415796 210 394 19.5238095238095 Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 AADAT Q64602 Rattus norvegicus (Rat) 4.47523711084511 5.24104166666667 1 1 0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Kynurenine aminotransferase II) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) Aadat Kat2 CLC4M Q9H2X3 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299) CLEC4M CD209L CD209L1 CD299 CD209 Q9NNX6 Homo sapiens (Human) 5.78777936757681 5.34375 2 2 0 CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) CD209 CLEC4L CNOT6 Q9ULM6 Homo sapiens (Human) 2 5.80052083333334 2 2 0 CCR4-NOT transcription complex subunit 6 (EC 3.1.13.4) (CCR4 carbon catabolite repression 4-like) (Carbon catabolite repressor protein 4 homolog) (Cytoplasmic deadenylase) CNOT6 CCR4 CCR4a KIAA1194 KCMA1 Q08460 Mus musculus (Mouse) 6.42550914491198 5.50416666666667 3 3 0 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo) Kcnma1 Kcnma KCMA1 Q12791 Homo sapiens (Human) 5.11636614668986 5.12998127210098 19 33 0 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) KCNMA1 KCNMA SLO KCMA1 Q28204 Bos taurus (Bovine) 4.3113708290022 4.8475 1 2 0 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (bSlo) KCNMA1 KCNMA NADE Q81RP3 Bacillus anthracis 3.99905899634694 5.07791666666667 2 2 0 NH(3)-dependent NAD(+) synthetase (EC 6.3.1.5) nadE BA_1998 GBAA_1998 BAS1855 CATE P14091 Homo sapiens (Human) 6.68 5.1046875 6 6 0 Cathepsin E (EC 3.4.23.34) [Cleaved into: Cathepsin E form I; Cathepsin E form II] CTSE PSA6 P60900 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-6 (EC 3.4.25.1) (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) PSMA6 PROS27 S10AA P60903 Homo sapiens (Human) 4.125 5.105 2 6 0 Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 ANX2LG CAL1L CLP11 ZAP70 P43403 Homo sapiens (Human) 4.62059478271202 5.29467299578059 79 111 5.06329113924051 Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase) ZAP70 SRK EST2 O00748 Homo sapiens (Human) 4.97377032501021 5.09029605263158 19 25 10.5263157894737 Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) CES2 ICE CA2D1 O08532 Mus musculus (Mouse) 7.1075 5.31666666666667 6 11 0 Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] Cacna2d1 Cacna2 CDC2H P61075 Plasmodium falciparum (isolate 3D7) 5.20333333333333 5.37208333333333 6 6 0 Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) CRK2 PK5 MAL13P1.279 STK3 Q13188 Homo sapiens (Human) 4.33577619883895 5.23701352163461 208 267 4.32692307692308 Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 DMPK Q09013 Homo sapiens (Human) 5.68544409588061 5.15291035353535 33 43 24.2424242424242 Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase) DMPK DM1PK MDPK CDK18 Q07002 Homo sapiens (Human) 5.466 5.33016666666667 10 13 10 Cyclin-dependent kinase 18 (EC 2.7.11.22) (Cell division protein kinase 18) (PCTAIRE-motif protein kinase 3) (Serine/threonine-protein kinase PCTAIRE-3) CDK18 PCTAIRE3 PCTK3 ADM2 Q7Z4H4 Homo sapiens (Human) 6.59875 4.95 8 8 0 ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)] ADM2 AM2 DRD5 Q8BLD9 Mus musculus (Mouse) 4.34242268082221 4.85 1 5 0 D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor) Drd5 MGLL Q8R431 Rattus norvegicus (Rat) 4.10349160175026 5.23142628205128 13 17 0 Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) Mgll Mgl2 ADA2B P19328 Rattus norvegicus (Rat) 6.28160374131765 5.28007728151412 191 742 0 Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) Adra2b TTL Q8NG68 Homo sapiens (Human) 5.73333333333333 5.05 3 3 0 Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) TTL PAR12 Q9H0J9 Homo sapiens (Human) 2 5.003125 1 1 0 Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 ARP2 P61160 Homo sapiens (Human) 4.52346347504627 5.17 2 2 0 Actin-related protein 2 (Actin-like protein 2) ACTR2 ARP2 DRD2 P61169 Rattus norvegicus (Rat) 5.92081579898264 5.33063516795654 256 656 0 D(2) dopamine receptor (Dopamine D2 receptor) Drd2 HCAR1 Q9BXC0 Homo sapiens (Human) 3.34192991352376 5.36211395842367 12 12 0 Hydroxycarboxylic acid receptor 1 (G-protein coupled receptor 104) (G-protein coupled receptor 81) HCAR1 GPR104 GPR81 HCA1 FKSG80 NCOR1 O75376 Homo sapiens (Human) 6.52632333477867 5.60333333333333 3 6 0 Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) NCOR1 KIAA1047 SC6A1 P31648 Mus musculus (Mouse) 5.16490980448681 5.19897644927536 23 27 0 Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 GSK3 P51136 Dictyostelium discoideum (Slime mold) 4.55 5.3125 2 2 0 Glycogen synthase kinase-3 (GSK-3) (EC 2.7.11.26) gskA gsk3 DDB_G0272110 AQP4 P55088 Mus musculus (Mouse) 5 5.13711375162601 2 6 0 Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aqp4 PDE3A Q14432 Homo sapiens (Human) 5.36067512427143 5.29531272408853 225 508 0.444444444444444 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) PDE3A QRFPR Q96P65 Homo sapiens (Human) 6.76857142857143 4.99174107142857 14 16 0 Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 KC1G3 Q9Y6M4 Homo sapiens (Human) 3.800068630291 5.24171527777778 150 195 6.66666666666667 Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) CSNK1G3 PKN1 Q16512 Homo sapiens (Human) 5.01947066608853 5.31165277777778 15 17 6.66666666666667 Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N) PKN1 PAK1 PKN PRK1 PRKCL1 ATG4B Q9Y4P1 Homo sapiens (Human) 4.73324324324325 5.29553490990991 37 37 32.4324324324324 Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagin-1) (Autophagy-related cysteine endopeptidase 1) (Autophagy-related protein 4 homolog B) (hAPG4B) ATG4B APG4B AUTL1 KIAA0943 JAK3 P52333 Homo sapiens (Human) 5.37647387026808 5.25634231956427 453 1022 1.76600441501104 Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) JAK3 CHIT1 Q13231 Homo sapiens (Human) 5.20748014236457 4.95 1 5 0 Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 PDPK1 O15530 Homo sapiens (Human) 4.45959196429255 5.28708662714097 253 277 3.95256916996047 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) PDPK1 PDK1 ACHP P58154 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 6.26970588235294 5.24834558823529 17 21 0 Acetylcholine-binding protein (ACh-binding protein) (AchBP) S10A4 P26447 Homo sapiens (Human) 5.77 5.76875 4 4 25 Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4) S100A4 CAPL MTS1 MURB P61431 Staphylococcus aureus 4.40866318725651 5.41907407407408 9 9 0 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase) murB RHOA P61586 Homo sapiens (Human) 4.42541343642563 5.1947619047619 14 18 0 Transforming protein RhoA (Rho cDNA clone 12) (h12) RHOA ARH12 ARHA RHO12 TNNT2 P45379 Homo sapiens (Human) 4.62783757783353 5.38527546296296 30 90 43.3333333333333 Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) TNNT2 HYES P34913 Homo sapiens (Human) 6.59609735570174 5.39017011278195 133 149 1.50375939849624 Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] EPHX2 ICK Q9UPZ9 Homo sapiens (Human) 5.646875 5.3946875 8 9 0 Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK) ICK KIAA0936 S40A1 Q9NP59 Homo sapiens (Human) 6.76782633323103 4.95 15 15 0 Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) SLC40A1 FPN1 IREG1 SLC11A3 MSTP079 CBX1 P83916 Homo sapiens (Human) 4.17590806691089 5.31806579740996 13538 13580 19.5302112572019 Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) CBX1 CBX CP1B1 Q16678 Homo sapiens (Human) 6.5646 5.21773333333333 25 28 16 Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) CYP1B1 LPAR5 Q9H1C0 Homo sapiens (Human) 5.21260809288144 5.3375 1 1 0 Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92) (G-protein coupled receptor 93) LPAR5 GPR92 GPR93 GSHR P47791 Mus musculus (Mouse) 2 4.9675 2 2 0 Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7) Gsr Gr1 RORG P51449 Homo sapiens (Human) 5.12901107738383 5.32388010528609 92 107 26.0869565217391 Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) RORC NR1F3 RORG RZRG PDE5A O76074 Homo sapiens (Human) 4.79562625406585 5.24689977853916 234 335 11.5384615384615 cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) PDE5A PDE5 1A15 Q37001 Arabidopsis thaliana (Mouse-ear cress) 6.985 4.8875 1 2 0 1-aminocyclopropane-1-carboxylate synthase 5 (ACC synthase 5) (EC 4.4.1.14) (Ethylene-overproduction protein 2) (S-adenosyl-L-methionine methylthioadenosine-lyase 5) ACS5 ACC5 ETO2 At5g65800 F6H11.90 MPA24.15 MRGX2 Q96LB1 Homo sapiens (Human) 6.3 4.95 1 1 0 Mas-related G-protein coupled receptor member X2 MRGPRX2 MRGX2 MRGX1 Q96LB2 Homo sapiens (Human) 5.87 5.254 5 5 0 Mas-related G-protein coupled receptor member X1 (Sensory neuron-specific G-protein coupled receptor 3/4) MRGPRX1 MRGX1 SNSR3 SNSR4 S22A4 Q9R141 Rattus norvegicus (Rat) 4.65251260309702 5.52287874528033 1 1 0 Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) Slc22a4 Octn1 TREM1 Q9NP99 Homo sapiens (Human) 5 4.975 1 13 0 Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354) TREM1 CDPK1 P62344 Plasmodium falciparum (isolate 3D7) 6.10819267904092 5.26219494047619 56 56 3.57142857142857 Calcium-dependent protein kinase 1 (EC 2.7.11.1) CPK1 CDPK1 PFB0815w RPOM O00411 Homo sapiens (Human) 4.09923699336882 5.03166666666667 3 3 0 DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6) POLRMT PEPD P12955 Homo sapiens (Human) 4.77680403582006 5.34375 4 4 0 Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) PEPD PRD DPOD1 P28340 Homo sapiens (Human) 2 4.9375 1 1 0 DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) POLD1 POLD MPIP1 P30304 Homo sapiens (Human) 4.57033439742244 5.24356072026359 35 42 2.85714285714286 M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) CDC25A M3K8 P41279 Homo sapiens (Human) 5.1297940008672 4.99958333333333 15 18 0 Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2) MAP3K8 COT ESTF PRGR P06401 Homo sapiens (Human) 6.55629599529841 5.2697670610049 117 176 0 Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3) PGR NR3C3 HS90A P07900 Homo sapiens (Human) 5.43904807993022 5.30780437403718 284 474 11.9718309859155 Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) HSP90AA1 HSP90A HSPC1 HSPCA OPRM P35372 Homo sapiens (Human) 4.87156881022905 5.30239838627884 370 600 13.7837837837838 Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) OPRM1 MOR1 LEP P00803 Escherichia coli (strain K12) 5.15169574418151 5.22916666666667 3 4 0 Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) lepB b2568 JW2552 AMPX Q01693 Vibrio proteolyticus (Aeromonas proteolytica) 2.41911313739254 5.43680989583333 16 18 0 Bacterial leucyl aminopeptidase (EC 3.4.11.10) PAOX Q6QHF9 Homo sapiens (Human) 3.65543440138275 4.93125 2 2 0 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) PAOX PAO UNQ1923/PRO4398 GBRA1 P62813 Rattus norvegicus (Rat) 6.17968511490235 5.15987625382021 301 5687 0.332225913621262 Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) Gabra1 Gabra-1 GBRA1 P62812 Mus musculus (Mouse) 2.39794000867204 5.9375 1 15 0 Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) Gabra1 Gabra-1 NEP Q61391 Mus musculus (Mouse) 4.98666666666667 5.9325 3 3 0 Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Mme MANBA O00462 Homo sapiens (Human) 4.00218240270122 5.625 2 2 0 Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) MANBA MANB1 LYAG P70699 Mus musculus (Mouse) 4 5.575 2 2 0 Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa NMD3A Q9R1M7 Rattus norvegicus (Rat) 5.33289708950963 5.38187063540494 433 4410 0.46189376443418 Glutamate receptor ionotropic, NMDA 3A (GluN3A) (Glutamate receptor chi-1) (N-methyl-D-aspartate receptor) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) (NMDAR-L1) Grin3a PPIA P62937 Homo sapiens (Human) 6.83044981096182 5.0226179245283 53 66 0 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] PPIA CYPA RAC1 P63000 Homo sapiens (Human) 5.13081128786115 5.33889294466125 15 21 0 Ras-related C3 botulinum toxin substrate 1 (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) RAC1 TC25 MIG5 PLMN Q01177 Rattus norvegicus (Rat) 4.8019266082173 5.69107142857143 7 7 0 Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B] Plg GBRB3 P63079 Rattus norvegicus (Rat) 6.20031565952008 5.16013068961001 308 5814 0.324675324675325 Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) Gabrb3 Gabrb-3 GBRB2 P63138 Rattus norvegicus (Rat) 6.20595170882759 5.16537207095196 313 6039 0.319488817891374 Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) Gabrb2 Gabrb-2 GBRB3 P63080 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) Gabrb3 Gabrb-3 GNAS2 P63092 Homo sapiens (Human) 4.97827381284825 5.34115680651076 14008 14444 19.6387778412336 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein) GNAS GNAS1 GSP MK01 P63085 Mus musculus (Mouse) 7.31862271931093 5.14993421052631 38 48 0 Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) Mapk1 Erk2 Mapk Prkm1 DHE3 P00366 Bos taurus (Bovine) 2 5.0625 1 1 0 Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) GLUD1 GLUD MK03 Q63844 Mus musculus (Mouse) 8.38863515617539 5.24305555555555 9 10 0 Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) Mapk3 Erk1 Prkm3 Q653V4 Q653V4 Oryza sativa subsp. japonica (Rice) 2 5.2 1 1 100 Os06g0676700 protein (Putative alpha-glucosidase) B1153E06.13-1 P0710B08.7-1 Os06g0676700 OSNPB_060676700 NCEH1 Q8BLF1 Mus musculus (Mouse) 5 5.375 1 1 0 Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP) Nceh1 Aadacl1 Kiaa1363 M3K9 P80192 Homo sapiens (Human) 5.46803620253629 5.17145679012346 54 85 20.3703703703704 Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) MAP3K9 MLK1 PRKE1 POLG P03300 Poliovirus type 1 (strain Mahoney) 3.45154499349597 5.0453125 2 2 0 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C) (EC 3.4.22.28); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)] HNMT Q9EST2 Cavia porcellus (Guinea pig) 4.25568439122025 5.52857142857143 7 10 0 Histamine N-methyltransferase (HMT) (EC 2.1.1.8) HNMT SUMO1 P63165 Homo sapiens (Human) 4.67596587902879 5.47353993252032 37 74 27.027027027027 Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) SUMO1 SMT3C SMT3H3 UBL1 OK/SW-cl.43 AL1A3 P47895 Homo sapiens (Human) 2.50457574905607 5.245625 5 6 0 Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3) ALDH1A3 ALDH6 GANAB Q14697 Homo sapiens (Human) 6.8803738003628 5.02499999999999 1 1 0 Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB G2AN KIAA0088 CSK2B P67870 Homo sapiens (Human) 5.44394064084885 5.2760195035461 94 381 8.51063829787234 Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) CSNK2B CK2N G5A KPCG P63319 Rattus norvegicus (Rat) 5.73836190596821 5.20642261904762 35 184 5.71428571428571 Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) Prkcg Pkcc Pkcg Prkcc CHK2 O96017 Homo sapiens (Human) 4.24330464090329 5.23250573799435 236 311 4.23728813559322 Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) CHEK2 CDS1 CHK2 RAD53 ALR P55789 Homo sapiens (Human) 5.77060010524795 5.20504926900585 285 285 24.2105263157895 FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin) GFER ALR HERV1 HPO SUMO2 P61956 Homo sapiens (Human) 4.94953451014678 5.4889659379065 8 16 12.5 Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) SUMO2 SMT3B SMT3H2 PK3CA P42336 Homo sapiens (Human) 6.41972521000428 5.29412515027508 567 779 0.529100529100529 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) PIK3CA ERBB2 P04626 Homo sapiens (Human) 3.81660574844888 5.26690014520915 372 538 8.60215053763441 Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340) ERBB2 HER2 MLN19 NEU NGL PARG Q9QYM2 Rattus norvegicus (Rat) 4.71 5.1625 2 2 0 Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) Parg ESR1 P49884 Bos taurus (Bovine) 4.42196980261338 5.0625 1 2 0 Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 NEP P08473 Homo sapiens (Human) 7.05260942701778 5.49340856481482 72 75 0 Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) MME EPN DXR P45568 Escherichia coli (strain K12) 5.06412815909759 5.30625 4 9 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) dxr ispC yaeM b0173 JW0168 AMYP P04746 Homo sapiens (Human) 7.68333333333333 4.95 3 3 0 Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) AMY2A KS6B2 Q9UBS0 Homo sapiens (Human) 4.43083706140514 5.353515625 8 16 0 Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) RPS6KB2 STK14B M3K4 Q9Y6R4 Homo sapiens (Human) 5.17866792257578 5.23954545454545 11 15 9.09090909090909 Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 SCN9A O08562 Rattus norvegicus (Rat) 6.54 4.95 2 2 0 Sodium channel protein type 9 subunit alpha (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) Scn9a CC14A Q9UNH5 Homo sapiens (Human) 4.30102999566398 5.6875 3 3 0 Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A KPCB P68403 Rattus norvegicus (Rat) 5.79529312593484 5.18757936507937 21 198 9.52380952380952 Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) Prkcb Pkcb Prkcb1 TBA1A P68370 Rattus norvegicus (Rat) 5.17 5.17083333333333 3 3 33.3333333333333 Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 TBA1B P68363 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] TUBA1B TBA4A P68366 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin alpha-4A chain (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) TUBA4A TUBA1 TBB4B P68371 Homo sapiens (Human) 5.05919164255692 5.21118091328656 73 1491 0 Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) TUBB4B TUBB2C ACOD1 P07308 Rattus norvegicus (Rat) 6.77184210526316 5.33771929824561 19 23 0 Acyl-CoA desaturase 1 (EC 1.14.19.1) (Delta(9)-desaturase 1) (Delta-9 desaturase 1) (Fatty acid desaturase 1) (Stearoyl-CoA desaturase 1) Scd1 Scd YOPH P08538 Yersinia pseudotuberculosis serotype I (strain IP32953) 3.53455950304647 5.64375 2 6 0 Tyrosine-protein phosphatase YopH (EC 3.1.3.48) (Virulence protein) yopH yop2b pYV0094 ACM1 P16395 Drosophila melanogaster (Fruit fly) 7.28989952463249 6.10229166666667 3 5 33.3333333333333 Muscarinic acetylcholine receptor DM1 mAChR-A AcrC mAcR-60C CG4356 TBA1A Q71U36 Homo sapiens (Human) 4.99932385729879 5.15529596560846 63 1395 0 Tubulin alpha-1A chain (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] TUBA1A TUBA3 S22AK Q80UJ1 Mus musculus (Mouse) 2.94692155651658 5.9625 1 1 0 Solute carrier family 22 member 20 (Organic anion transporter 6) Slc22a20 Gm963 Oat6 SC5A7 Q8BGY9 Mus musculus (Mouse) 5.15 5.59375 2 2 0 High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) Slc5a7 Cht1 SC5A2 Q923I7 Mus musculus (Mouse) 8.335 5.03194444444444 3 4 0 Sodium/glucose cotransporter 2 (Na(+)/glucose cotransporter 2) (Low affinity sodium-glucose cotransporter) (Solute carrier family 5 member 2) Slc5a2 Sglt2 TRPM6 Q9BX84 Homo sapiens (Human) 5 5.37208333333333 6 6 0 Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) TRPM6 CHAK2 KTHY P23919 Homo sapiens (Human) 3.18 5.026875 2 2 0 Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) DTYMK CDC8 TMPK TYMK CPT1A P50416 Homo sapiens (Human) 6.5 6.1 1 1 0 Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) CPT1A CPT1 PYRD Q02127 Homo sapiens (Human) 5.30193737706704 5.20325556070184 94 99 1.06382978723404 Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) DHODH PARG Q86W56 Homo sapiens (Human) 2.92693598216088 5.6125 2 2 0 Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG CAN1 P97571 Rattus norvegicus (Rat) 7.64 5.0625 1 1 0 Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) Capn1 Cls1 SCNAA Q62968 Rattus norvegicus (Rat) 6.22 5.30578703703704 9 9 0 Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) Scn10a Sns SCNAA Q6QIY3 Mus musculus (Mouse) 5.55 5.0375 3 4 0 Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) Scn10a Sns STK38 Q15208 Homo sapiens (Human) 4.924742501084 5.3290625 8 9 0 Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) STK38 NDR1 TRPA1 Q6RI86 Rattus norvegicus (Rat) 4.90680326849995 5.16875816993464 17 36 0 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) Trpa1 Anktm1 TRPA1 Q8BLA8 Mus musculus (Mouse) 4.49 5.4625 1 1 0 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) Trpa1 Anktm1 DEF P68826 Staphylococcus aureus 8.92 5.025 1 1 0 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) def def1 pdf1 CP4F3 Q08477 Homo sapiens (Human) 4.71869201097007 4.93749999999999 1 1 0 Docosahexaenoic acid omega-hydroxylase CYP4F3 (EC 1.14.13.199) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.13.30) CYP4F3 LTB4H ACHB4 Q8R493 Mus musculus (Mouse) 5.88643937264017 4.85 2 11 0 Neuronal acetylcholine receptor subunit beta-4 Chrnb4 Acrb4 CARM1 Q9WVG6 Mus musculus (Mouse) 5.43149500072267 5.04333333333333 6 6 0 Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) Carm1 Prmt4 TRPM8 Q8R455 Rattus norvegicus (Rat) 5.08145496280192 5.24695932539683 14 32 0 Transient receptor potential cation channel subfamily M member 8 (Cold menthol receptor 1) Trpm8 Cmr1 TAF1L Q8IZX4 Homo sapiens (Human) 6.9 4.9975 1 1 0 Transcription initiation factor TFIID subunit 1-like (TAF(II)210) (TBP-associated factor 1-like) (TBP-associated factor 210 kDa) (Transcription initiation factor TFIID 210 kDa subunit) TAF1L SYFA P68849 Staphylococcus aureus 7.38857142857143 5.54642857142857 7 7 0 Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) pheS PDE4D P14270 Rattus norvegicus (Rat) 6.28346715986667 6.065390625 8 47 0 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) Pde4d TGM1 P22735 Homo sapiens (Human) 4.88563667100269 5.46055555555556 6 6 0 Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 KTG RIPK1 Q13546 Homo sapiens (Human) 5.52939393939394 5.30537878787879 11 16 18.1818181818182 Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP) RIPK1 RIP RIP1 POLG P26664 Hepatitis C virus genotype 1a (isolate 1) (HCV) 5.04350499927733 5.47164395860433 12 26 0 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] MMP12 P39900 Homo sapiens (Human) 6.11152450932832 5.50062218468469 74 84 2.7027027027027 Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12) MMP12 HME EGFR P00533 Homo sapiens (Human) 4.88012879246334 5.24452473687789 816 1355 4.77941176470588 Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) EGFR ERBB ERBB1 HER1 PDE4B Q07343 Homo sapiens (Human) 5.84055532695725 5.28989484016392 274 919 0.72992700729927 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) PDE4B DPDE4 ACK1 Q07912 Homo sapiens (Human) 4.2798125885678 5.22686997901101 149 214 6.71140939597315 Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 SC6A4 P31645 Homo sapiens (Human) 5.55465911624095 5.21855153448736 364 497 7.14285714285714 Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) SLC6A4 HTT SERT KDM1A O60341 Homo sapiens (Human) 5.52530387925925 5.19442175444302 57 75 1.75438596491228 Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) KDM1A AOF2 KDM1 KIAA0601 LSD1 CLC6A Q6EIG7 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 C-type lectin domain family 6 member A (C-type lectin superfamily member 10) (Dendritic cell-associated C-type lectin 2) (DC-associated C-type lectin 2) (Dectin-2) CLEC6A CLECSF10 DECTIN2 CLC4C Q8WTT0 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303) CLEC4C BDCA2 CLECSF11 CLECSF7 DLEC HECL UNQ9361/PRO34150 AGRA P0A0I7 Staphylococcus aureus 5.22 4.9125 1 1 0 Accessory gene regulator protein A agrA agr AMYG P69328 Aspergillus niger 4.28431811792051 5.27291666666667 2 2 0 Glucoamylase (EC 3.2.1.3) (1,4-alpha-D-glucan glucohydrolase) (Glucan 1,4-alpha-glucosidase) GLAA GYRB P0A0K8 Staphylococcus aureus 6.89940148371633 5.3310054940295 29 38 0 DNA gyrase subunit B (EC 5.99.1.3) gyrB KITH Q9QNF7 Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1) 4.5875 5.24833333333333 4 4 0 Thymidine kinase (EC 2.7.1.21) TK UL23 GBRD O14764 Homo sapiens (Human) 6.09195841807574 5.23624669312169 63 1120 1.58730158730159 Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta) GABRD SIK1 P57059 Homo sapiens (Human) 4.72031258329928 5.23284548611111 60 102 13.3333333333333 Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) SIK1 SIK SNF1LK NTRK1 P04629 Homo sapiens (Human) 4.70386267186462 5.30157269700673 331 395 2.41691842900302 High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) NTRK1 MTC TRK TRKA SYTC P26639 Homo sapiens (Human) 7.04 5.3875 1 1 0 Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) TARS MAST1 Q9Y2H9 Homo sapiens (Human) 5.12285714285714 5.38857142857143 7 8 0 Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) MAST1 KIAA0973 SAST PARN O95453 Homo sapiens (Human) 4.08 4.875 1 1 0 Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) PARN DAN DPOLA P09884 Homo sapiens (Human) 4.4431029995664 5.47291666666667 10 12 0 DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) POLA1 POLA FTSZ P0A031 Staphylococcus aureus 4.78154208652845 5.29875 8 9 0 Cell division protein FtsZ ftsZ LEP P0A070 Staphylococcus aureus 3.87 4.946875 2 2 0 Signal peptidase IB (SPase IB) (EC 3.4.21.89) (Leader peptidase IB) spsB MURD P0A091 Staphylococcus aureus 4.31999729719821 5.37427083333333 8 8 0 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) murD NORA P0A0J7 Staphylococcus aureus 4.41721550619782 5.05475490196078 17 49 5.88235294117647 Quinolone resistance protein NorA norA FAAH1 O00519 Homo sapiens (Human) 5.62227433206466 5.22871944068382 73 79 1.36986301369863 Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1) FAAH FAAH1 XBP1 P17861 Homo sapiens (Human) 4.33706634377926 5.37353137860082 81 81 35.8024691358025 X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form] XBP1 TREB5 XBP2 FA7 P08709 Homo sapiens (Human) 6.13378737028041 5.42160037878788 44 115 0 Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain] F7 CHIB1 Q873X9 Neosartorya fumigata (Aspergillus fumigatus) 5.32 6.0625 1 1 0 Endochitinase B1 (EC 3.2.1.14) (Chitinase B1) chiB1 DPP4 P27487 Homo sapiens (Human) 6.22035667176319 5.31159428374287 470 579 0.212765957446809 Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] DPP4 ADCP2 CD26 PIM1 P11309 Homo sapiens (Human) 5.76869629218303 5.20990320144047 524 656 2.67175572519084 Serine/threonine-protein kinase pim-1 (EC 2.7.11.1) PIM1 PP2BB P16298 Homo sapiens (Human) 4.04575749056067 4.95 1 1 0 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) PPP3CB CALNA2 CALNB CNA2 HIPK3 Q9H422 Homo sapiens (Human) 5.84283594910484 5.1890462962963 45 71 20 Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1) HIPK3 DYRK6 FIST3 PKY SFRP1 Q8N474 Homo sapiens (Human) 7.07766682466377 5.358 5 11 0 Secreted frizzled-related protein 1 (FRP-1) (sFRP-1) (Secreted apoptosis-related protein 2) (SARP-2) SFRP1 FRP FRP1 SARP2 AROC P0A2Y6 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 4.99 5.2 1 1 0 Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) aroC SP_1374 FKB1B P68106 Homo sapiens (Human) 7.97333333333333 4.95 3 3 0 Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4 GYRB P0A4L9 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 6.29 5.12847222222222 3 3 0 DNA gyrase subunit B (EC 5.99.1.3) gyrB SP_0806 IF2A Q6ZWX6 Mus musculus (Mouse) 5 4.96875 2 2 0 Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) Eif2s1 Eif2a IKBA Q9Z1E3 Mus musculus (Mouse) 2 4.85 1 2 0 NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) Nfkbia Ikba MRAY P0A6W3 Escherichia coli (strain K12) 3.70010233984907 5.125 4 4 0 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) mraY murX b0087 JW0085 PBP2 P0A3M5 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 6.37872753600686 5.4 1 9 0 Penicillin-binding protein 2B penA pbp2b SP_1673 PSBA P69560 Spinacia oleracea (Spinach) 5.02415784025641 5.21736111111111 9 14 0 Photosystem II protein D1 (PSII D1 protein) (EC 1.10.3.9) (32 kDa thylakoid membrane protein) (Photosystem II Q(B) protein) psbA APH1B Q8WW43 Homo sapiens (Human) 4.97578556722111 5.14483913502109 79 912 0 Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like) APH1B PSFL UNQ688/PRO1328 MDM2 Q00987 Homo sapiens (Human) 6.40009334421476 5.18696218297101 138 193 5.07246376811594 E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) MDM2 ESR2 Q92731 Homo sapiens (Human) 4.66401070476256 5.25649060366683 450 760 11.7777777777778 Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ESR2 ESTRB NR3A2 IKKA O15111 Homo sapiens (Human) 4.52619755564704 5.22063849272931 149 216 3.35570469798658 Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) CHUK IKKA TCF16 ATR Q13535 Homo sapiens (Human) 6.42333333333333 5.23954166666667 10 18 10 Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1) ATR FRP1 ATSA Q9X759 Klebsiella pneumoniae 2 5.01875 1 1 0 Arylsulfatase (AS) (EC 3.1.6.1) (Aryl-sulfate sulphohydrolase) atsA 5HT1B Q9N2B7 Gorilla gorilla gorilla (Western lowland gorilla) 5.11 6.13833333333333 3 3 0 5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (Serotonin receptor 1B) HTR1B RPOA P0A7Z4 Escherichia coli (strain K12) 5.08820075263658 4.9675 4 128 0 DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) rpoA pez phs sez b3295 JW3257 NTR1 P30989 Homo sapiens (Human) 6.22079616773182 5.07794871794871 39 40 2.56410256410256 Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH) NTSR1 NTRR CELA1 Q9UNI1 Homo sapiens (Human) 6.08333333333333 5.28333333333333 3 3 0 Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) (Pancreatic elastase 1) CELA1 ELA1 RET4 P02753 Homo sapiens (Human) 5.76587541614226 5.20152777777778 9 10 0 Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)] RBP4 PRO2222 Q57TT1 Q57TT1 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 4.72901799419835 5.36945799959209 1207 1208 29.2460646230323 Uncharacterized protein Tb927.8.6820 GP119 Q8TDV5 Homo sapiens (Human) 6.06375128458988 5.29222630718954 34 56 0 Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) GPR119 SUFU Q9UMX1 Homo sapiens (Human) 5 4.915 1 1 0 Suppressor of fused homolog (SUFUH) SUFU UNQ650/PRO1280 5HT2A O46635 Canis lupus familiaris (Dog) (Canis familiaris) 4.52287874528034 4.9125 1 2 0 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (5-hydroxytryptamine receptor) (Serotonin receptor 2A) HTR2A 5-HTR2A KIF4A O95239 Homo sapiens (Human) 2.26996479304806 5.09458333333333 6 6 0 Chromosome-associated kinesin KIF4A (Chromokinesin-A) KIF4A KIF4 ADCY1 Q08828 Homo sapiens (Human) 6.90378865958889 4.848125 2 10 0 Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) ADCY1 ESTD Q9R0P3 Mus musculus (Mouse) 5 5.375 1 1 0 S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase 10) (Esterase D) (Sid 478) Esd Es10 Sid478 LMBL3 Q96JM7 Homo sapiens (Human) 5.30794779641829 5.13416666666667 9 11 0 Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (MBT-1) L3MBTL3 KIAA1798 MBT1 TRPV4 Q9ERZ8 Rattus norvegicus (Rat) 6.2831259982636 5.19401960784314 17 51 0 Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) Trpv4 Vroac TRPV2 Q9WUD2 Rattus norvegicus (Rat) 6.2831259982636 5.19401960784314 17 51 0 Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Stretch-activated channel 2B) (Vanilloid receptor-like protein 1) (VRL-1) Trpv2 Sac2b Vrl1 TRPV3 Q8NET8 Homo sapiens (Human) 5.04781833550134 5.16597222222222 6 6 0 Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 TRPV4 Q9EPK8 Mus musculus (Mouse) 5.14551499783199 6.29999999999999 4 4 0 Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) Trpv4 Trp12 Vrl2 Vroac TRPV4 Q9HBA0 Homo sapiens (Human) 4.88812160180082 5.29166666666666 3 4 0 Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) TRPV4 VRL2 VROAC ACHA3 Q8R4G9 Mus musculus (Mouse) 8.25 4.85 1 9 0 Neuronal acetylcholine receptor subunit alpha-3 Chrna3 ACHA2 Q91X60 Mus musculus (Mouse) 8.25 4.85 1 9 0 Neuronal acetylcholine receptor subunit alpha-2 Chrna2 GBRP Q8QZW7 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit pi (GABA(A) receptor subunit pi) Gabrp TBB1 Q9H4B7 Homo sapiens (Human) 5.06377402715978 5.18595720720721 74 1492 0 Tubulin beta-1 chain TUBB1 CBPB1 P09955 Sus scrofa (Pig) 5.7468636235841 5.157 5 6 0 Carboxypeptidase B (EC 3.4.17.2) CPB1 CPB TF65 Q04206 Homo sapiens (Human) 5.20350866168107 5.27465915469451 835 4202 82.9940119760479 Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) RELA NFKB3 SRPK3 Q9UPE1 Homo sapiens (Human) 4.68146965309305 5.25803472222222 60 81 13.3333333333333 SRSF protein kinase 3 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1) (Serine/arginine-rich protein-specific kinase 3) (SR-protein-specific kinase 3) (Serine/threonine-protein kinase 23) SRPK3 MSSK1 STK23 E2AK4 Q9P2K8 Homo sapiens (Human) 5.51017534877581 5.30659090909091 11 14 9.09090909090909 eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 XIAP P98170 Homo sapiens (Human) 5.18684356445897 5.41093767806268 117 204 11.965811965812 E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) XIAP API3 BIRC4 IAP3 AROA P0A6D3 Escherichia coli (strain K12) 4.51969829618526 5.4578125 8 14 0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) aroA b0908 JW0891 GLCM P04062 Homo sapiens (Human) 4.85545375220994 5.32262136062816 1499 1627 26.2841894596398 Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) GBA GC GLUC GBRA5 Q8BHJ7 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) Gabra5 ACHB3 Q8BMN3 Mus musculus (Mouse) 8.25 4.85 1 9 0 Neuronal acetylcholine receptor subunit beta-3 Chrnb3 CDK13 Q14004 Homo sapiens (Human) 5.32666666666667 5.37208333333333 6 6 0 Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) CDK13 CDC2L CDC2L5 CHED KIAA1791 ISPD P69834 Arabidopsis thaliana (Mouse-ear cress) 7.46 5.14219100130081 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (AtMECT) (AtMEPCT) ISPD MCT MECT MEPCT At2g02500 T8K22.20 CKX1 Q9T0N8 Zea mays (Maize) 5.13671789191888 5.23125 2 2 0 Cytokinin dehydrogenase 1 (EC 1.5.99.12) (Cytokinin oxidase 1) (CKO 1) (COX 1) (ZmCKX1) CKX1 TESK1 Q15569 Homo sapiens (Human) 4.84887993001566 5.28922619047619 14 17 7.14285714285714 Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1) TESK1 DPP8 Q6V1X1 Homo sapiens (Human) 4.53722826231378 5.3917754703365 194 200 0 Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) DPP8 DPRP1 MSTP097 MSTP135 MSTP141 DPP9 Q86TI2 Homo sapiens (Human) 4.65979351205589 5.35588138599978 121 126 0 Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) DPP9 DPRP2 DPP9 Q8BVG4 Mus musculus (Mouse) 5 5.375 1 1 0 Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) Dpp9 NAGAB Q58DH9 Bos taurus (Bovine) 4.39794000867204 5.07625 2 2 0 Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA NAGAB Q90744 Gallus gallus (Chicken) 3.72986665015988 5.875 14 14 0 Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA SMBT1 Q9UHJ3 Homo sapiens (Human) 3.26143937264017 4.9 1 2 0 Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) SFMBT1 RU1 Q8II92 Q8II92 Plasmodium falciparum (isolate 3D7) 3.99249083539008 5.24583333333333 6 6 0 Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative) PF11_0282 PF3D7_1127100 CHK1 O14757 Homo sapiens (Human) 5.11766999559174 5.24937222836683 487 600 2.46406570841889 Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) CHEK1 CHK1 LPXC P0A725 Escherichia coli (strain K12) 3.81957866606544 4.995625 4 4 25 UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (Protein EnvA) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase) lpxC asmB envA b0096 JW0094 MURA P0A749 Escherichia coli (strain K12) 4.59166666666667 4.875 1 6 0 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) murA murZ b3189 JW3156 RPOZ P0A800 Escherichia coli (strain K12) 5.08820075263658 4.9675 4 128 0 DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymerase omega subunit) (Transcriptase subunit omega) rpoZ b3649 JW3624 RPOC P0A8T7 Escherichia coli (strain K12) 5.08820075263658 4.9675 4 128 0 DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') rpoC tabB b3988 JW3951 FA9 P00740 Homo sapiens (Human) 6.13449276946935 5.2594362745098 34 34 0 Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain] F9 PK3CD O00329 Homo sapiens (Human) 5.99797084370147 5.28225241416309 233 375 0.858369098712446 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) PIK3CD TRAP1 Q12931 Homo sapiens (Human) 5.6175 5.72265625 4 5 0 Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) TRAP1 HSP75 NK2R P21452 Homo sapiens (Human) 3.93901733981099 5.25977360100139 123 198 21.9512195121951 Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 NK2R NKNAR TAC2R TGFR2 P37173 Homo sapiens (Human) 5.37415212790925 5.27409722222222 12 15 8.33333333333333 TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) TGFBR2 NCEH1 Q6PIU2 Homo sapiens (Human) 4.71970588235294 5.19442401960784 17 21 0 Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) NCEH1 AADACL1 KIAA1363 NAAA Q5KTC7 Rattus norvegicus (Rat) 6.14949913205538 5.31724780701754 19 29 0 N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] Naaa Asahl ACH10 Q9JLB5 Rattus norvegicus (Rat) 6.84903136558255 5.20630208333334 76 972 1.31578947368421 Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) Chrna10 M3K13 O43283 Homo sapiens (Human) 5.31857142857143 5.38857142857143 7 8 0 Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) MAP3K13 LZK XPO1 O14980 Homo sapiens (Human) 2.91666666666667 5.22291666666667 9 34 0 Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) XPO1 CRM1 ACHA9 P43144 Rattus norvegicus (Rat) 6.91441059167937 5.21958051801802 74 970 1.35135135135135 Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) Chrna9 Acra9 CDK9 P50750 Homo sapiens (Human) 5.57623370860012 5.21192909194936 198 343 5.55555555555556 Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) CDK9 CDC2L4 TAK ICAM1 P05362 Homo sapiens (Human) 5.9097451284433 5.2447485380117 57 173 0 Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54) ICAM1 ADA2B P30545 Mus musculus (Mouse) 2.705 5.25458333333333 4 15 0 Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) Adra2b HDAC2 Q92769 Homo sapiens (Human) 5.59954496166184 5.2826323640892 296 3819 0.675675675675676 Histone deacetylase 2 (HD2) (EC 3.5.1.98) HDAC2 GPR35 Q9HC97 Homo sapiens (Human) 4.87529000107581 5.3927251984127 42 128 16.6666666666667 G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor) GPR35 MINK1 Q8N4C8 Homo sapiens (Human) 4.41967131067215 5.24213805379747 158 203 5.06329113924051 Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) MINK1 B55 MAP4K6 MINK YSK2 ZC3 BAP1 Q92560 Homo sapiens (Human) 2 6.125 1 1 0 Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) BAP1 KIAA0272 hucep-6 POLG Q9WMX2 Hepatitis C virus genotype 1b (isolate Con1) (HCV) 8.2275 4.976875 4 4 0 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] XPP1 Q9NQW7 Homo sapiens (Human) 4.22847274948967 5.322 5 10 0 Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) XPNPEP1 XPNPEPL XPNPEPL1 TP4A3 O75365 Homo sapiens (Human) 3.44575392501777 5.36520833333333 6 14 0 Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) PTP4A3 PRL3 TP4A2 Q12974 Homo sapiens (Human) 3.31149096946755 5.15375 5 6 0 Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) PTP4A2 PRL2 PTPCAAX2 BM-008 TP4A1 Q93096 Homo sapiens (Human) 3.35509915503314 5.15375 5 6 0 Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) PTP4A1 PRL1 PTPCAAX1 DYRK4 Q9NR20 Homo sapiens (Human) 2.73317941770782 5.23374763257576 88 88 0 Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) DYRK4 TBB6 Q9BUF5 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin beta-6 chain (Tubulin beta class V) TUBB6 Q38C41 Q38C41 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 4.9350340859818 5.44344301975942 44 44 0 Phosphotransferase (EC 2.7.1.-) Tb10.70.5800 VGFR2 P35968 Homo sapiens (Human) 5.66338455741787 5.25524622472425 870 1109 1.14942528735632 Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) KDR FLK1 VEGFR2 RBSK P0A9J6 Escherichia coli (strain K12) 3.52287874528034 5.7375 1 1 0 Ribokinase (RK) (EC 2.7.1.15) rbsK b3752 JW3731 BRPF3 Q9ULD4 Homo sapiens (Human) 3.36666666666667 5.05229166666667 3 6 0 Bromodomain and PHD finger-containing protein 3 BRPF3 KIAA1286 CETP P11597 Homo sapiens (Human) 5.62454735938095 5.53352192982456 19 22 10.5263157894737 Cholesteryl ester transfer protein (Lipid transfer protein I) CETP NMD3B O60391 Homo sapiens (Human) 5.64373444877251 5.21261513157895 38 364 0 Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B) GRIN3B FTSZ P0A9A6 Escherichia coli (strain K12) 3.89279003035213 5.23071968632008 2 2 0 Cell division protein FtsZ ftsZ sfiB sulB b0095 JW0093 PHEA P0A9J8 Escherichia coli (strain K12) 3.92081875395238 5.0875 1 1 0 P-protein [Includes: Chorismate mutase (CM) (EC 5.4.99.5); Prephenate dehydratase (PDT) (EC 4.2.1.51)] pheA b2599 JW2580 TRPV1 O35433 Rattus norvegicus (Rat) 6.04430344141349 5.39093029433276 46 116 0 Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Vanilloid receptor type 1-like) Trpv1 Vr1 Vr1l ACE2 Q9BYF1 Homo sapiens (Human) 6.36216666666667 5.35340277777778 30 51 0 Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2] ACE2 UNQ868/PRO1885 DLG4 P78352 Homo sapiens (Human) 4.34733333333333 5.053 5 8 0 Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) DLG4 PSD95 HNF4A P41235 Homo sapiens (Human) 5.15795364854323 5.40794117647059 17 17 35.2941176470588 Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) HNF4A HNF4 NR2A1 TCF14 KPYM P14618 Homo sapiens (Human) 3.47102632866009 5.36445939054438 1173 2361 40.7502131287298 Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 MSRA P54149 Bos taurus (Bovine) 3.73728973818942 5.16633928571429 42 42 23.8095238095238 Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) MSRA PHF8 Q9UPP1 Homo sapiens (Human) 4.62 6.425 1 2 0 Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8) PHF8 KIAA1111 ZNF422 OXSR1 O95747 Homo sapiens (Human) 5.08231766841005 5.33736979166667 8 9 0 Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) OXSR1 KIAA1101 OSR1 Q3Y5H1 Q3Y5H1 Infectious bronchitis virus 3.53555779565238 5.23147135416667 16 16 18.75 3C-like protease (Fragment) P3C2B O00750 Homo sapiens (Human) 5.49430667457968 5.31328703703704 18 22 5.55555555555556 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) PIK3C2B LIPR2 P81139 Cavia porcellus (Guinea pig) 2 5.79375 4 4 0 Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (GPL) (Galactolipase) PNLIPRP2 NPCL1 Q6T3U3 Rattus norvegicus (Rat) 5 5.2375 1 1 0 Niemann-Pick C1-like protein 1 Npc1l1 PB1 Q86U86 Homo sapiens (Human) 5.06143937264017 5.23625 2 2 0 Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 ABHD5 Q9DBL9 Mus musculus (Mouse) 5 5.375 1 1 0 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC 2.3.1.51) (Abhydrolase domain-containing protein 5) (Lipid droplet-binding protein CGI-58) (Protein CGI-58) Abhd5 TRPV1 Q8NER1 Homo sapiens (Human) 5.89569288820145 5.22774657767497 233 338 17.5965665236052 Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) TRPV1 VR1 XYND O00089 Aspergillus niger 2 4.90833333333333 1 2 0 Exo-1,4-beta-xylosidase xlnD (EC 3.2.1.37) (1,4-beta-D-xylan xylohydrolase xlnD) (Beta-xylosidase A) (Beta-xylosidase xlnD) (Xylobiase xlnD) xlnD xylA CAN Q5AJ71 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 6.92428571428571 5.16345238095238 7 7 0 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) (Non-classical export protein 103) NCE103 CAALFM_C301300CA CaO19.1721 CaO19.9289 CHIA1 Q873Y0 Neosartorya fumigata (Aspergillus fumigatus) 3.13123198451976 5.54583333333333 3 5 0 Endochitinase A1 (EC 3.2.1.14) (Chitinase A1) chiA1 chi1 OGA O60502 Homo sapiens (Human) 8.92181818181818 5.11875 11 11 0 Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (EC 3.2.1.-) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) MGEA5 HEXC KIAA0679 MEA5 5HT3B O95264 Homo sapiens (Human) 6.36488646007373 5.45688844086021 31 199 0 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) HTR3B ANO1 Q5XXA6 Homo sapiens (Human) 4.99333333333333 5.33 3 3 0 Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) ANO1 DOG1 ORAOV2 TAOS2 TMEM16A GGYF2 Q6Y7W6 Homo sapiens (Human) 3.71625 5.225 2 7 0 GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) GIGYF2 KIAA0642 PERQ2 TNRC15 PARP8 Q8N3A8 Homo sapiens (Human) 2 5.003125 1 1 0 Poly [ADP-ribose] polymerase 8 (PARP-8) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) PARP8 ENASE Q8NFI3 Homo sapiens (Human) 4.37519695125945 5.81333333333333 15 15 0 Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) ENGASE P4K2B Q8TCG2 Homo sapiens (Human) 4.61536876553715 5.3726842948718 26 184 0 Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) PI4K2B PHOP1 Q8TCT1 Homo sapiens (Human) 2.93970259163113 5.34033854166667 8 10 12.5 Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) PHOSPHO1 ACER1 Q8TDN7 Homo sapiens (Human) 5 5.65 1 1 0 Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3) ACER1 ASAH3 PI3R5 Q8WYR1 Homo sapiens (Human) 6.26818181818182 5.14962121212121 11 88 0 Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K) PIK3R5 NOX5 Q96PH1 Homo sapiens (Human) 6.44 5.8275 1 1 0 NADPH oxidase 5 (EC 1.6.3.-) NOX5 PARPT Q7Z3E1 Homo sapiens (Human) 2 5.003125 1 1 0 TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) TIPARP PARP7 S22A9 Q8IVM8 Homo sapiens (Human) 4.39794000867204 5.575 3 3 0 Solute carrier family 22 member 9 (Organic anion transporter 7) SLC22A9 hOAT4 OAT7 UST3 RIR2B Q7LG56 Homo sapiens (Human) 4.70685422469503 5.37222222222222 9 40 11.1111111111111 Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) RRM2B P53R2 S47A2 Q86VL8 Homo sapiens (Human) 4.45 5.78643937264017 2 2 0 Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2) SLC47A2 MATE2 KMT5C Q86Y97 Homo sapiens (Human) 5 5.35 1 1 0 Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) KMT5C SUV420H2 PP7130 PK3C3 Q8NEB9 Homo sapiens (Human) 5.69540460672061 5.18154166666667 10 10 0 Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) PIK3C3 VPS34 AKTS1 Q96B36 Homo sapiens (Human) 5 5.175 1 1 0 Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) AKT1S1 PRAS40 S47A1 Q96FL8 Homo sapiens (Human) 4.63563915021217 5.35259468632008 4 7 50 Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1) SLC47A1 MATE1 PCFT Q96NT5 Homo sapiens (Human) 6.32814393726402 5.18249999999999 4 8 0 Proton-coupled folate transporter (G21) (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) SLC46A1 HCP1 PCFT DGAT2 Q96PD7 Homo sapiens (Human) 4.61092437480818 5.44375 2 2 0 Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase 2) DGAT2 HMFN1045 UNQ738/PRO1433 S22AC Q96S37 Homo sapiens (Human) 6.4453382173006 5.15446172136703 19 20 0 Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) SLC22A12 OATL4 URAT1 UNQ6453/PRO34004 SPSB2 Q99619 Homo sapiens (Human) 3.57796535579438 4.99955357142857 7 7 14.2857142857143 SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9) SPSB2 GRCC9 SSB2 PHF23 Q9BUL5 Homo sapiens (Human) 4.52287874528034 5.55666666666667 3 3 0 PHD finger protein 23 (PDH-containing protein JUNE-1) PHF23 ABHD6 Q9BV23 Homo sapiens (Human) 3.67656109841065 5.37008333333333 5 10 0 Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) ABHD6 UBA5 Q9GZZ9 Homo sapiens (Human) 2 5.209375 6 6 0 Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 BHMT2 Q9H2M3 Homo sapiens (Human) 5.61862646600762 4.9125 4 6 0 S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 ELOV6 Q9H5J4 Homo sapiens (Human) 5.83 5.19017857142857 7 7 0 Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6) ELOVL6 FACE LCE BRD7 Q9NPI1 Homo sapiens (Human) 5 5.20375 2 2 0 Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1) BRD7 BP75 CELTIX1 PAR11 Q9NR21 Homo sapiens (Human) 2 5.003125 1 1 0 Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) PARP11 C12orf6 S22AB Q9NSA0 Homo sapiens (Human) 5.01960112919699 5.7375 3 3 33.3333333333333 Solute carrier family 22 member 11 (Organic anion transporter 4) SLC22A11 OAT4 ASF1A Q9Y294 Homo sapiens (Human) 4.225 5.02838541666667 4 4 0 Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) ASF1A CGI-98 HSPC146 ACATN O00400 Homo sapiens (Human) 8.67933333333334 5.39375 30 30 0 Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1) SLC33A1 ACATN AT1 S27A5 Q9Y2P5 Homo sapiens (Human) 2 5.40604166666667 3 3 0 Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) SLC27A5 ACSB ACSVL6 FACVL3 FATP5 ELF3 P78545 Homo sapiens (Human) 2 4.925 1 2 0 ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) ELF3 ERT ESX JEN S27A4 Q6P1M0 Homo sapiens (Human) 4.71143937264017 5.4625 2 2 0 Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4) SLC27A4 ACSVL4 FATP4 ATS13 Q76LX8 Homo sapiens (Human) 4.7 4.825 1 1 0 A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease) ADAMTS13 C9orf8 UNQ6102/PRO20085 ALKB3 Q96Q83 Homo sapiens (Human) 5.46645457656133 4.98848214285714 7 8 0 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) ALKBH3 ABH3 DEPC1 P4K2A Q9BTU6 Homo sapiens (Human) 4.5824852822845 5.37142113095238 28 186 0 Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) PI4K2A S28A3 Q9HAS3 Homo sapiens (Human) 4.39333333333333 5.32833333333333 3 3 0 Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3) SLC28A3 CNT3 DUS22 Q9NRW4 Homo sapiens (Human) 4.08517600346882 5.273 5 5 0 Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) DUSP22 JSP1 LMWDSP2 MKPX DBF4A Q9UBU7 Homo sapiens (Human) 6.47250050836179 5.19826388888889 27 62 0 Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) DBF4 ASK DBF4A ZDBF1 AMOT Q4VCS5 Homo sapiens (Human) 5 4.95 2 5 0 Angiomotin AMOT KIAA1071 M3K19 Q56UN5 Homo sapiens (Human) 6.26799242723084 5.37527777777778 9 10 0 Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4) MAP3K19 RCK YSK4 MRP7 Q5T3U5 Homo sapiens (Human) 5.0796263641787 5.325 2 2 50 Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10) ABCC10 MRP7 SIMRP7 NEK5 Q6P3R8 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 NIM1 Q8IY84 Homo sapiens (Human) 5 5.35770833333333 8 9 0 Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) NIM1K NIM1 MK15 Q8TD08 Homo sapiens (Human) 5.31922158418785 5.24667438271605 27 34 14.8148148148148 Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) MAPK15 ERK7 ERK8 TBB2B Q9BVA1 Homo sapiens (Human) 4.86861789999606 5.21262090773809 56 1155 0 Tubulin beta-2B chain TUBB2B NUAK2 Q9H093 Homo sapiens (Human) 5.52450778074392 5.35825 10 12 10 NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) NUAK2 OMPHK2 SNARK NMUR1 Q9HB89 Homo sapiens (Human) 2 4.98848214285714 7 7 28.5714285714286 Neuromedin-U receptor 1 (NMU-R1) (G-protein coupled receptor 66) (G-protein coupled receptor FM-3) NMUR1 GPR66 TBK1 Q9UHD2 Homo sapiens (Human) 4.33406835622602 5.22586265659292 145 246 6.20689655172414 Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) TBK1 NAK FADS2 O95864 Homo sapiens (Human) 2.89965666811201 5.44930555555556 3 3 0 Fatty acid desaturase 2 (EC 1.14.19.3) (Acyl-CoA 6-desaturase) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) FADS2 TBB2A Q13885 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin beta-2A chain (Tubulin beta class IIa) TUBB2A TUBB2 SBK1 Q52WX2 Homo sapiens (Human) 5.085 5.37208333333333 6 6 0 Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1) SBK1 GP139 Q6DWJ6 Homo sapiens (Human) 7.304 4.90916666666667 5 5 0 Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) GPR139 GPRG1 PGR3 ATAD2 Q6PL18 Homo sapiens (Human) 5.23265191450544 5.10875 17 36 0 ATPase family AAA domain-containing protein 2 (EC 3.6.1.3) (AAA nuclear coregulator cancer-associated protein) (ANCCA) ATAD2 L16 PRO2000 CDKL3 Q8IVW4 Homo sapiens (Human) 5 5.38857142857143 7 8 0 Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE) CDKL3 NKIAMRE HIPK4 Q8NE63 Homo sapiens (Human) 3.65519787800488 5.25519510582011 126 153 0 Homeodomain-interacting protein kinase 4 (EC 2.7.11.1) HIPK4 HCAR2 Q8TDS4 Homo sapiens (Human) 5.62627208840217 5.33181858093321 101 160 0 Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor) HCAR2 GPR109A HCA2 HM74A NIACR1 OXER1 Q8TDS5 Homo sapiens (Human) 3.94978787452803 5.37918187581301 4 9 0 Oxoeicosanoid receptor 1 (5-oxo-ETE G-protein coupled receptor) (G-protein coupled receptor 170) (G-protein coupled receptor R527) (G-protein coupled receptor TG1019) OXER1 GPR170 TG1019 GPBAR Q8TDU6 Homo sapiens (Human) 5.69966360327547 5.288125 22 26 4.54545454545455 G-protein coupled bile acid receptor 1 (G-protein coupled receptor GPCR19) (hGPCR19) (Membrane-type receptor for bile acids) (M-BAR) (hBG37) (BG37) GPBAR1 TGR5 ABCCB Q96J66 Homo sapiens (Human) 4.88605664769316 4.925 1 1 0 ATP-binding cassette sub-family C member 11 (Multidrug resistance-associated protein 8) ABCC11 MRP8 RCOR1 Q9UKL0 Homo sapiens (Human) 5.28301947174379 5.32864583333333 3 6 0 REST corepressor 1 (Protein CoREST) RCOR1 KIAA0071 RCOR S22A6 Q4U2R8 Homo sapiens (Human) 4.66734224454606 5.30833333333333 3 3 0 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1) SLC22A6 OAT1 PAHT PFKA O15648 Trypanosoma brucei brucei 4.88526161062203 5.37141967610985 933 1243 23.1511254019293 ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) pfk IMDH Q8T6T2 Cryptosporidium parvum 6.26655041540199 5.05598958333333 12 15 0 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) 56k.02 cgd6_20 GBRB Q75NA5 Musca domestica (House fly) 5.74062121402824 5.20107638888889 6 11 0 Gamma-aminobutyric acid receptor subunit beta (GABA(A) receptor subunit beta) (MdRdl) Rdl PGH1 O97554 Oryctolagus cuniculus (Rabbit) 5.41041199826559 4.982 5 5 0 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 BGAL Q58D55 Bos taurus (Bovine) 3.60693297530413 5.38490384615385 13 13 0 Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) GLB1 PGTB1 Q5EAD5 Bos taurus (Bovine) 5.92558539751274 5.42204545454545 22 44 0 Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) PGGT1B KCS17 O65677 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 17 (KCS-17) (EC 2.3.1.199) (Very long-chain fatty acid condensing enzyme 17) (VLCFA condensing enzyme 17) KCS17 KCS2 At4g34510 T4L20.90 KCS18 Q38860 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 18 (KCS-18) (EC 2.3.1.199) (Protein FATTY ACID ELONGATION 1) (Very long-chain fatty acid condensing enzyme 18) (VLCFA condensing enzyme 18) FAE1 KCS18 At4g34520 T4L20.100 ILVB1 Q41768 Zea mays (Maize) 4.67760612776763 6.45 3 10 33.3333333333333 Acetolactate synthase 1, chloroplastic (EC 2.2.1.6) (Acetohydroxy-acid synthase 1) ALS1 AHAS108 ILVB2 Q41769 Zea mays (Maize) 4.67760612776763 6.45 3 10 33.3333333333333 Acetolactate synthase 2, chloroplastic (EC 2.2.1.6) (Acetohydroxy-acid synthase 2) ALS2 AHAS109 AHK4 Q9C5U0 Arabidopsis thaliana (Mouse-ear cress) 4.25122555507378 5.33805555555556 9 9 11.1111111111111 Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG) AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2 AHK3 Q9C5U1 Arabidopsis thaliana (Mouse-ear cress) 4.85022888792533 5.34444444444445 9 9 0 Histidine kinase 3 (EC 2.7.13.3) (Arabidopsis histidine kinase 3) (AtHK3) (Protein AUTHENTIC HIS-KINASE 3) (Protein ORESARA 12) AHK3 ORE12 At1g27320 F17L21.11 KCS1 Q9MAM3 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 1 (KCS-1) (EC 2.3.1.199) (Very long-chain fatty acid condensing enzyme 1) (VLCFA condensing enzyme 1) KCS1 EL1 At1g01120 T25K16.11 KCS20 Q9FG87 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 20 (KCS-20) (EC 2.3.1.199) (Very long-chain fatty acid condensing enzyme 20) (VLCFA condensing enzyme 20) KCS20 KCS19 At5g43760 MQD19.11 LOX15 Q43191 Solanum tuberosum (Potato) 2 4.8875 1 1 0 Probable linoleate 9S-lipoxygenase 5 (EC 1.13.11.58) (Leaf lipoxygenase) LOX1.5 POTLX-3 KCS5 Q9C6L5 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 5 (KCS-5) (EC 2.3.1.199) (Eceriferum 60) (Very long-chain fatty acid condensing enzyme 5) (VLCFA condensing enzyme 5) KCS5 CER60 At1g25450 F2J7.9 ABAH3 Q9FH76 Arabidopsis thaliana (Mouse-ear cress) 6.04217450083873 5.5425 5 11 0 Abscisic acid 8'-hydroxylase 3 (ABA 8'-hydroxylase 3) (EC 1.14.13.93) (Cytochrome P450 707A3) CYP707A3 At5g45340 K9E15.12 CXE12 Q9SMN0 Arabidopsis thaliana (Mouse-ear cress) 5 5.0875 1 1 0 Probable carboxylesterase 12 (AtCXE12) (EC 3.1.1.1) CXE12 At3g48690 T8P19.200 DNLJ Q9AIU7 Staphylococcus aureus 6.557 5.3364875 10 11 0 DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) ligA lig Q46991 Q46991 Enterobacter cloacae 7.55 5.8975 1 1 0 Beta-lactamase (EC 3.5.2.6) imiA blaIMI-1 imi-1 AW879_08570 Q6W9J1 Q6W9J1 Enterobacter cloacae 4.45661881316309 5.19921875 8 8 0 Beta-lactamase (EC 3.5.2.6) blaTEM-1 bla bla_1 blaTEM blaTEM-1b BZY51_16985 BZY52_26055 SAMEA2273136_04951 SAMEA2273167_05071 SAMEA2273187_04856 SAMEA2273228_03952 SAMEA2273283_05277 FABF Q5TKS0 Staphylococcus aureus 2 5.41083333333333 7 7 0 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.179) (3-oxoacyl-[acyl-carrier-protein] synthase II) (Beta-ketoacyl-ACP synthase II) (KAS II) (Fragment) fabF QPCT Q16769 Homo sapiens (Human) 5.95203786420601 5.12985677083333 24 31 4.16666666666667 Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) QPCT SPEB P0C0J0 Streptococcus pyogenes 2 5.4875 2 2 0 Streptopain (EC 3.4.22.10) (Exotoxin type B) (SPE B) (Streptococcal cysteine proteinase) (Streptococcus peptidase A) (SPP) speB KCJ11 Q14654 Homo sapiens (Human) 5.95966433159246 5.27171556712963 32 172 0 ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11) KCNJ11 GRM2 Q14416 Homo sapiens (Human) 4.46459636646021 5.41205596751413 118 169 1.69491525423729 Metabotropic glutamate receptor 2 (mGluR2) GRM2 GPRC1B MGLUR2 GBA3 Q9H227 Homo sapiens (Human) 2.33478826846748 5.40833333333333 3 3 0 Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase-like protein 1) GBA3 CBG CBGL1 CP2AD Q16696 Homo sapiens (Human) 6.2475 5.205078125 2 4 0 Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13) CYP2A13 GRIA3 P42263 Homo sapiens (Human) 5.10789851424354 5.32527083333333 10 37 0 Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) GRIA3 GLUR3 GLURC FNTB Q8K2I1 Mus musculus (Mouse) 5.17892303263779 5.3821875 6 12 0 Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) Fntb PI51C O60331 Homo sapiens (Human) 4.74666666666667 5.243 15 15 0 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma) PIP5K1C KIAA0589 PORCN Q9JJJ7 Mus musculus (Mouse) 6.45401999710932 5.29583333333333 3 3 0 Protein-serine O-palmitoleoyltransferase porcupine (mPORC) (EC 2.3.1.-) Porcn Porc Ppn TAOK3 Q9H2K8 Homo sapiens (Human) 5.75468162551019 5.15042214912281 38 62 23.6842105263158 Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) TAOK3 DPK JIK KDS MAP3K18 DHRS9 Q8VD48 Rattus norvegicus (Rat) 4.37318928235376 5.3125 2 4 0 Dehydrogenase/reductase SDR family member 9 (EC 1.1.-.-) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8) Dhrs9 LCK P06240 Mus musculus (Mouse) 5.83317458508996 5.20263888888889 6 6 0 Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK) Lck Lsk-t CBX8 Q9HC52 Homo sapiens (Human) 5.72 4.9375 1 1 0 Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) CBX8 PC3 RC1 KPCI P41743 Homo sapiens (Human) 3.93790195587335 5.25885230368195 191 893 3.66492146596859 Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) PRKCI DXS1179E NPSR1 Q8BZP8 Mus musculus (Mouse) 7.02713117686392 4.95 39 40 0 Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) Npsr1 Gpr154 Pgr14 ALF P0AB71 Escherichia coli (strain K12) 3.72796597782486 5.0690625 2 2 0 Fructose-bisphosphate aldolase class 2 (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) (Fructose-bisphosphate aldolase class II) fbaA fba fda b2925 JW2892 DHPS P0AC13 Escherichia coli (strain K12) 4.92612553504005 5.0947619047619 7 8 0 Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) folP dhpS b3177 JW3144 GLMU P0ACC7 Escherichia coli (strain K12) 5.52279295704506 5.4259375 8 11 0 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] glmU yieA b3730 JW3708 Q7B899 Q7B899 Klebsiella pneumoniae 5.02715224604361 5.775 1 1 0 Beta-lactamase (EC 3.5.2.6) bla bla_3 blaTEM-1 blaTEM-1b blaTEM-208 blaTEM1b blaTEM1H TEM-1 tem-1 tem1 AGG09_00275 AGG09_00635 AGG09_01420 AM359_02235 AM390_29475 AM390_29905 AM447_30620 AU29_01460 AU29_03790 AU29_05870 B4U22_36255 B8011_20690 BL102_0016090 IPF_38 KP64216b_00107 LG39_00235 pc15-k-014 pCT-KPC_032 PENVA_0157 pKF94-115 PUUH_pUUH2392p0204 SAMEA3531778_05835 SM57_05108 SM57_05581 Q9AQH7 Q9AQH7 Staphylococcus aureus 4.33 4.9625 1 1 0 Replicative DNA helicase (EC 3.6.4.12) dnaC TOP3 P96583 Bacillus subtilis (strain 168) 4.32597817043386 5.20972222222222 9 18 0 DNA topoisomerase 3 (EC 5.99.1.2) (DNA topoisomerase III) topB BSU04260 CQSS Q9KM66 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 5.10131261732673 4.94571428571429 7 7 0 CAI-1 autoinducer sensor kinase/phosphatase CqsS (EC 2.7.13.3) (EC 3.1.3.-) (Cholerae quorum-sensing sensor) cqsS VC_A0522 GLFT2 O53585 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2 4.9975 2 2 0 Galactofuranosyltransferase GlfT2 (GalTr 2) (EC 2.4.1.288) (Arabinogalactan galactosyltransferase 2) (Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase) (Polymerizing galactofuranosyltransferase GlfT2) glfT2 glfT Rv3808c Q81W29 Q81W29 Bacillus anthracis 5.92 5.0325 1 1 0 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) guaB GBAA_0008 PYRC Q81WF0 Bacillus anthracis 2 4.95 1 1 100 Dihydroorotase (DHOase) (EC 3.5.2.3) pyrC BA_4027 GBAA_4027 BAS3739 MURI Q836J0 Enterococcus faecalis (strain ATCC 700802 / V583) 5.375 5.26875 2 2 0 Glutamate racemase (EC 5.1.1.3) murI EF_1121 Q93T40 Q93T40 Bacillus anthracis 4.02264666955735 5.62444444444445 3 4 0 Beta-lactamase (EC 3.5.2.6) bla2 GBAA_3500 Q5NGQ3 Q5NGQ3 Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) 5.425 5.4 2 2 0 Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9) fabI FTT_0782 GLMU Q97R46 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 4.26959851308232 5.72416666666667 3 3 0 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] glmU SP_0988 Q9I056 Q9I056 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.99811419147265 5.64657738095238 7 7 0 Carboxypeptidase G2 cpg2 PA2787 MTAD Q9X034 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 3.67778070526608 5.35 1 1 0 5-methylthioadenosine/S-adenosylhomocysteine deaminase (MTA/SAH deaminase) (EC 3.5.4.28) (EC 3.5.4.31) mtaD TM_0936 Q9X6W0 Q9X6W0 Pseudomonas aeruginosa 5.81954393554187 5.4 1 1 0 Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) ponB CAZ10_03050 KPYK Q6GG09 Staphylococcus aureus (strain MRSA252) 4.9530294163989 5.1535 10 13 0 Pyruvate kinase (PK) (EC 2.7.1.40) pyk SAR1776 O53430 O53430 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 3.83560745597552 5.153125 4 4 0 Mycothiol S-conjugate amidase (EC 3.5.1.115) mca LH57_05935 P71716 P71716 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 6.754 5.36525 10 13 0 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase mbtA Rv2384 EPHB P95276 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 5.27698877482274 5.153125 4 4 0 Epoxide hydrolase B (EHB) (EC 3.3.2.10) MT1988 P96830 P96830 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 4.49609608362698 5.206875 8 12 0 Uncharacterized protein MT0162 P96878 P96878 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 6.37 5.1235 10 10 0 Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase) Rv3273 Q81WN7 Q81WN7 Bacillus anthracis 6.21379714527951 5.025 2 2 0 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA2 dapA GBAA_3935 BASH2_02000 Q9HUY3 Q9HUY3 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.82390874094432 5.05381944444445 9 9 0 Arylamine N-acetyltransferase PA4827 O69638 O69638 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 5.18227703726729 5.149375 4 4 0 Hydrolase, alpha/beta hydrolase fold family MT3771 Q9FBC5 Q9FBC5 Streptococcus pneumoniae 5.46491001300805 5.36 5 7 0 2-nitropropane dioxygenase (Enoyl-ACP reductase II) (EC 1.13.12.16) (EC 1.3.1.9) (Putative enoyl-(Acyl-carrier-protein) reductase II) (EC 1.3.-.-) (Trans-2-enoyl-ACP reductase II) fabK fabK_1 AWW74_11355 ERS019416_00326 ERS019687_00144 ERS020138_00781 ERS020158_00154 ERS020525_00230 ERS020528_00394 ERS020532_00901 ERS020726_00825 ERS020831_00410 ERS021733_02209 ERS022390_01437 ERS232497_00402 ERS232524_01992 ERS367337_02077 Q9HUN3 Q9HUN3 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.64666666666667 5.19583333333333 3 3 0 Replicative DNA helicase (EC 3.6.4.12) dnaB PA4931 PPCE O70196 Rattus norvegicus (Rat) 7.62125802973095 5.53153409090909 11 16 0 Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) Prep ACACA Q5SWU9 Mus musculus (Mouse) 5.71547288568131 5.4 1 2 100 Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) (Acetyl-CoA carboxylase 265) [Includes: Biotin carboxylase (EC 6.3.4.14)] Acaca Acac Gm738 SGMR1 Q60492 Cavia porcellus (Guinea pig) 6.8110480422788 5.23934905660377 53 59 0 Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) (Sterol isomerase-like protein) SIGMAR1 OPRS1 TERT Q673L6 Rattus norvegicus (Rat) 6 5.4375 1 1 0 Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) Tert Q80Z26 Q80Z26 Rattus norvegicus (Rat) 4.9 4.95 1 1 0 Ectonucleoside triphosphate diphosphohydrolase 3 (Ectonucleoside triphosphate diphosphohydrolase 3, isoform CRA_a) (Nucleoside triphosphate diphosphohydrolase 3) Entpd3 ntpdase3 rCG_25968 Q99P97 Q99P97 Rattus norvegicus (Rat) 6.11896417190388 5.4537037037037 9 140 11.1111111111111 Histone deacetylase 6 (Fragment) Hdac6 5HT3B Q9JJ16 Rattus norvegicus (Rat) 7.01686699604491 5.33566275224667 114 366 0.87719298245614 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) Htr3b Q56D28 Q56D28 Cavia porcellus (Guinea pig) 5.53 5.05416666666667 3 3 0 Chemoattractant receptor-homologous molecule expressed on Th2 cells (Prostaglandin D2 receptor 2) CRTH2 PTGDR2 O70282 O70282 Rattus norvegicus (Rat) 6.43 5.125 2 2 0 Trehalase (EC 3.2.1.28) (Alpha-trehalose glucohydrolase) (Fragment) Treh Q7TT78 Q7TT78 Rattus norvegicus (Rat) 3.65250251854486 5.515625 1 2 0 Chloride channel isoform 1 (Fragment) Clcn1 Q8VBU5 Q8VBU5 Mus musculus (Mouse) 7.16714285714286 5.27276785714286 7 27 0 Phosphodiesterase (EC 3.1.4.-) Pde4b mCG_113038 MOT10 Q91Y77 Rattus norvegicus (Rat) 5.46007041390387 5.16423611111111 3 6 0 Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1) Slc16a10 Mct10 Tat1 DYR Q920D2 Rattus norvegicus (Rat) 4.63556709590583 5.3427178030303 44 49 0 Dihydrofolate reductase (EC 1.5.1.3) Dhfr S22A7 Q5RLM2 Rattus norvegicus (Rat) 5.74 7.3 1 1 100 Solute carrier family 22 member 7 (Novel liver transporter) (Organic anion transporter 2) Slc22a7 Nlt Oat2 S22A1 Q63089 Rattus norvegicus (Rat) 3.72777264689251 5.4625 2 4 0 Solute carrier family 22 member 1 (Organic cation transporter 1) (rOCT1) Slc22a1 Oct1 Q9EPR9 Q9EPR9 Rattus norvegicus (Rat) 5.205 5.38495535714286 14 45 0 Phosphodiesterase (EC 3.1.4.-) Pde1a S22A2 Q9R0W2 Rattus norvegicus (Rat) 3.33163771198942 5.20625 2 6 0 Solute carrier family 22 member 2 (Organic cation transporter 2) (rOCT2) Slc22a2 Oct2 S22A8 Q9R1U7 Rattus norvegicus (Rat) 4.65048043205064 4.88 1 1 0 Solute carrier family 22 member 8 (Organic anion transporter 3) (rOat3) Slc22a8 Oat3 Q8CFK4 Q8CFK4 Mus musculus (Mouse) 3.79169633170664 5.505 5 7 0 Tyrosine-protein kinase (EC 2.7.10.2) Tec ABHD6 Q8R2Y0 Mus musculus (Mouse) 6.42863525754497 5.375 2 9 0 Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) Abhd6 5HT3B Q9JHJ5 Mus musculus (Mouse) 3.915 5.7984375 2 4 0 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B) Htr3b SGMR1 O55242 Mus musculus (Mouse) 7.25990524408388 5.47217756410256 15 48 0 Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) Sigmar1 Oprs1 KMO O88867 Rattus norvegicus (Rat) 5.2260618048337 5.39291666666667 6 8 0 Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) Kmo ALD1 Q5RJP0 Rattus norvegicus (Rat) 4.69815309326393 5.74625 5 5 0 Aldose reductase-related protein 1 (EC 1.1.1.21) (Aldehyde reductase) (Aldo-keto reductase family 1 member B7) (Aldose reductase-like protein AKR1B14) Akr1b7 Akr1b14 Q5RJZ2 Q5RJZ2 Rattus norvegicus (Rat) 6.11896417190388 5.4537037037037 9 140 11.1111111111111 Hdac5 protein (Fragment) Hdac5 Q66HS9 Q66HS9 Rattus norvegicus (Rat) 4.55344711695733 5.56125 2 2 0 Monocarboxylate transporter 2 (RCG59598, isoform CRA_b) (Slc16a7 protein) Slc16a7 rCG_59598 Q6P1E0 Q6P1E0 Mus musculus (Mouse) 5.664 4.876 5 5 0 Tyrosine-protein kinase (EC 2.7.10.2) Syk Sykb HDAC3 Q6P6W3 Rattus norvegicus (Rat) 5.32433877356746 5.17291666666667 2 28 0 Histone deacetylase 3 (HD3) (EC 3.5.1.98) Hdac3 LYAG Q6P7A9 Rattus norvegicus (Rat) 4.88408023042484 5.06555989583333 16 24 0 Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa ASAH1 Q6P7S1 Rattus norvegicus (Rat) 6.97440415202343 5.66270833333334 12 12 0 Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) Asah1 ABHDA Q6PE15 Mus musculus (Mouse) 6.60229180054851 5.36409090199117 3 3 0 Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC 3.1.1.93) (Alpha/beta hydrolase domain-containing protein 10) (Abhydrolase domain-containing protein 10) Abhd10 S22A6 O35956 Rattus norvegicus (Rat) 5.40166383332931 5.005 2 2 0 Solute carrier family 22 member 6 (Organic anion transporter 1) (rOAT1) (renal organic anion transporter 1) (rROAT1) Slc22a6 Oat1 SCN8A O88420 Rattus norvegicus (Rat) 4.56916974543363 5.0846875 10 12 0 Sodium channel protein type 8 subunit alpha (Peripheral nerve protein type 4) (PN4) (Sodium channel 6) (NaCh6) (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) Scn8a Q63380 Q63380 Rattus norvegicus (Rat) 5.08893174088114 5.34548177083333 16 23 0 Transporter NET Q7TNH1 Q7TNH1 Mesocricetus auratus (Golden hamster) 6.31 5.425 1 1 0 Peroxisome proliferator-activated receptor alpha (peroxisome proliferator-activated receptor alpha isoform X2) ppara Ppara RHBL4 Q8BHC7 Mus musculus (Mouse) 5 5.375 1 1 0 Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (mRHBDD1) (Rhomboid-like protein 4) Rhbdd1 Rhbdl4 MSD-50 MSD50 PLPL2 Q8BJ56 Mus musculus (Mouse) 4.29510170064054 5.265625 5 10 20 Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Desnutrin) Pnpla2 Atgl Q8CFM9 Q8CFM9 Rattus norvegicus (Rat) 3.83 4.90416666666667 3 24 0 Adenylyl cyclase 7 (Fragment) PLPL8 Q8K1N1 Mus musculus (Mouse) 5 5.375 1 1 0 Calcium-independent phospholipase A2-gamma (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (Patatin-like phospholipase domain-containing protein 8) Pnpla8 Ipla22 Ipla2g S22A6 Q8VC69 Mus musculus (Mouse) 3.235 5.40625 2 3 0 Solute carrier family 22 member 6 (Kidney-specific transport protein) (Novel kidney transcript) (mNKT) (Organic anion transporter 1) (Renal organic anion transporter 1) (mROAT1) Slc22a6 Nkt Oat1 Q91ZM7 Q91ZM7 Rattus norvegicus (Rat) 6.2768949495321 5.16136976091668 339 7456 1.17994100294985 GABA theta subunit Gabrq Q9EQ79 Q9EQ79 Mus musculus (Mouse) 5 4.8125 1 3 100 Alkaline phosphatase (EC 3.1.3.1) SCN4A Q9ER60 Mus musculus (Mouse) 7.05 4.95 1 1 0 Sodium channel protein type 4 subunit alpha (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) Scn4a Q9JKS8 Q9JKS8 Rattus norvegicus (Rat) 5 4.8125 1 3 100 Alkaline phosphatase (EC 3.1.3.1) Akp3 Alpi2 IAP-II Q9QXI6 Q9QXI6 Mus musculus (Mouse) 5.50281833550134 4.94166666666667 3 4 0 SGLT1 protein (Sodium/glucose cotransporter 1) (Solute carrier family 5 (Sodium/glucose cotransporter), member 1) Slc5a1 Sglt1 Q9WTR4 Q9WTR4 Rattus norvegicus (Rat) 6.41945357517996 5.2427269520881 89 109 1.12359550561798 Transporter Slc6a2 Q64546 Q64546 Rattus norvegicus (Rat) 7.275 5.1875 1 2 0 Cytochrome P450c11B3 CYP11B3 BACE2 Q6IE75 Rattus norvegicus (Rat) 8.7 5.20625 2 3 0 Beta-secretase 2 (EC 3.4.23.45) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase) Bace2 Q6PSM0 Q6PSM0 Rattus norvegicus (Rat) 4.71896663275227 4.9625 1 1 0 Multidrug resistance protein 1a Mdr1a ABHDD Q80UX8 Mus musculus (Mouse) 5 5.375 1 1 0 Protein ABHD13 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 13) (Abhydrolase domain-containing protein 13) Abhd13 HCAR2 Q80Z39 Rattus norvegicus (Rat) 4.81723088890211 5.69464285714286 7 7 0 Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109) (G-protein coupled receptor 109A) (G-protein coupled receptor HM74) (Niacin receptor 1) (Nicotinic acid receptor) (Protein PUMA-G) Hcar2 Gpr109 Gpr109a Gpr109b Niacr1 Pumag ADRB2 Q8K4Z4 Cavia porcellus (Guinea pig) 6.24115384615385 5.30701923076923 26 28 0 Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) Adrb2 Q8VH26 Q8VH26 Cavia porcellus (Guinea pig) 6.33456950471037 5.184 27 30 0 Muscarinic acetylcholine receptor GPM3 Q8VH27 Q8VH27 Cavia porcellus (Guinea pig) 7.74 4.93749999999999 4 8 0 Muscarinic acetylcholine receptor (Fragment) GPM2 CHRM2 HRH4 Q91ZY1 Rattus norvegicus (Rat) 5.87919275640723 5.33138157894737 19 37 0 Histamine H4 receptor (H4R) (HH4R) Hrh4 HCAR2 Q9EP66 Mus musculus (Mouse) 2 5.70715062581301 8 8 0 Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109) (G-protein coupled receptor 109A) (G-protein coupled receptor HM74) (Niacin receptor 1) (Nicotinic acid receptor) (Protein PUMA-G) Hcar2 Gpr109 Gpr109a Gpr109b Niacr1 Pumag Q9ERT1 Q9ERT1 Mus musculus (Mouse) 5.62926499783199 4.938125 4 8 0 Thyrotropin-releasing hormone receptor 2 (Fragment) TRH-R2 Q9JKC1 Q9JKC1 Rattus norvegicus (Rat) 5.23958952910284 5.28563683579001 16 18 0 Carboxylic ester hydrolase (EC 3.1.1.-) Bche rCG_62812 Q9JLY8 Q9JLY8 Rattus norvegicus (Rat) 6.61666666666667 5.1325 3 3 0 C-C motif chemokine receptor 1 (Chemokine (C-C motif) receptor 1) (Macrophage inflammatory protein-1 alpha receptor) Ccr1 rCG_25213 Q9R297 Q9R297 Rattus norvegicus (Rat) 5.05928571428571 5.19821428571429 7 14 0 Motilin receptor (Thyrotropin-releasing hormone receptor 2) Mlnr TRH-R2 Trhr2 rCG_51576 HDAC1 Q4QQW4 Rattus norvegicus (Rat) 5.32433877356746 5.17291666666667 2 28 0 Histone deacetylase 1 (HD1) (EC 3.5.1.98) Hdac1 PARE Q79EC5 Escherichia coli 7.02 5.37166666666667 3 3 0 Toxin ParE (Gyrase inhibitor ParE) parE Q6QCL9 Q6QCL9 Human herpesvirus 3 (HHV-3) (Varicella-zoster virus) 5.38378557059493 5.51294642857143 7 27 0 Thymidine kinase (EC 2.7.1.21) ORF 36 ORF36 TK HHV3_E_SVETAgp38 HHV3_gp38 HHV3gp38 HHV3M2gp38 Q8JXU8 Q8JXU8 Hepatitis C virus 5.57291732037536 5.26586674528302 106 138 0 RNA-directed RNA polymerase (EC 2.7.7.48) (Fragment) NS5B PA Q9IQ47 Influenza A virus (strain A/X-31 H3N2) 3.30102999566398 4.86 1 1 0 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2) PA Q91H74 Q91H74 Dengue virus 2 4.27396329167372 5.34041666666667 8 9 0 Genome polyprotein Q6Q793 Q6Q793 Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1)) 9.28 7.05 1 1 0 Neuraminidase (EC 3.2.1.18) NA NRAM Q9IGQ6 Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1)) 4.665 5.05 1 2 0 Neuraminidase (EC 3.2.1.18) NA GLYCP Q9IH62 Nipah virus 3.03230333766935 5.23861111111111 3 3 0 Glycoprotein G G Q9IP65 Q9IP65 Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 4.038 6.06 1 5 0 G protein-coupled receptor US28 Q4U254 Q4U254 Human rhinovirus sp. 6.01467274254204 5.31691506410256 52 81 0 Protease (Fragment) protease Q804I7 Q804I7 Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) 2 5.42 1 2 0 Sodium/hydrogen exchanger Q9W6Q1 Q9W6Q1 Amphiuma tridactylum (three-toed salamander) 2 5.42 1 2 0 Sodium/hydrogen exchanger NHE1 Q98UH1 Q98UH1 Danio rerio (Zebrafish) (Brachydanio rerio) 4.9 4.89791666666667 1 1 0 Mu opioid receptor-like OR2 oprm1 or2 P88142 P88142 Human immunodeficiency virus 2 4.76264666955735 4.98923611111111 3 3 0 Pol polyprotein pol Q72547 Q72547 Human immunodeficiency virus 1 5.78059095370285 5.22950175875135 356 653 0.561797752808989 Reverse transcriptase/RNaseH (Fragment) pol Q76270 Q76270 Human immunodeficiency virus 1 6.58083333333333 5.04166666666667 12 12 0 GP41 (Fragment) HIV1 ENV Q7ZJM1 Q7ZJM1 Human immunodeficiency virus 1 5.19575699327805 5.26171992481203 133 235 3.7593984962406 Integrase (Fragment) pol Q9WKE8 Q9WKE8 Human immunodeficiency virus 1 5.01060936135981 5.20447727059735 20 24 0 Reverse transcriptase (Fragment) reverse transcriptase BACE1 P56817 Homo sapiens (Human) 6.07090022164605 5.29011207210239 537 758 0.37243947858473 Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) BACE1 BACE KIAA1149 Q8WSF8 Q8WSF8 Aplysia californica (California sea hare) 7.61 5.61 2 2 0 Soluble acetylcholine receptor BZLF1 P03206 Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) 3.95372188928133 5.64002314814815 18 18 44.4444444444444 Trans-activator protein BZLF1 (EB1) (Zebra) BZLF1 FFAR4 Q5NUL3 Homo sapiens (Human) 5.12877205412333 5.30708333333333 6 7 0 Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1) FFAR4 GPR120 GPR129 O3FAR1 PGR4 TAA7B Q923X8 Rattus norvegicus (Rat) 7.00133333333334 5.02959722222222 15 15 0 Trace amine-associated receptor 7b (TaR-7b) (Trace amine receptor 7b) (Trace amine receptor 12) (TaR-12) Taar7b Ta12 Tar12 Trar12 MAST3 O60307 Homo sapiens (Human) 5.38199226309292 4.975 2 4 0 Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1) MAST3 KIAA0561 JUN P18870 Gallus gallus (Chicken) 2 4.8625 1 1 0 Transcription factor AP-1 (Proto-oncogene c-Jun) JUN KAT2B Q92831 Homo sapiens (Human) 4.44957272316129 5.18898065476191 28 62 3.57142857142857 Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) KAT2B PCAF PE2R1 P34995 Homo sapiens (Human) 6.49478723868073 5.23074766817847 26 32 0 Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor) PTGER1 GP142 Q7Z601 Homo sapiens (Human) 6.59350189518016 5.25893939393939 11 18 0 Probable G-protein coupled receptor 142 (G-protein coupled receptor PGR2) GPR142 PGR2 CAH9 Q16790 Homo sapiens (Human) 7.05607648191315 5.28440825020781 401 558 1.49625935162095 Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) CA9 G250 MN TOPK Q96KB5 Homo sapiens (Human) 2.89165115256935 5.20542850378788 88 88 0 Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase) PBK TOPK DSBA P0AEG4 Escherichia coli (strain K12) 3.665 4.865625 6 6 0 Thiol:disulfide interchange protein DsbA dsbA dsf ppfA b3860 JW3832 NPC1 O15118 Homo sapiens (Human) 5.59205574354922 5.16838625910941 7513 7615 63.8626380939704 Niemann-Pick C1 protein NPC1 ROCK1 Q13464 Homo sapiens (Human) 4.85920131567935 5.2577192771966 311 373 1.28617363344051 Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) ROCK1 AURKB Q96GD4 Homo sapiens (Human) 5.47739919282561 5.26705224346428 402 501 2.48756218905473 Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B) AURKB AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5 Q2Q167 Q2Q167 Hepatitis C virus 3.67505322579539 5.353 11 11 18.1818181818182 Core protein (Fragment) BKRB1 Q3BCU0 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 6.22 5.5 1 1 0 B1 bradykinin receptor (B1R) (BK-1 receptor) BDKRB1 FABI P0AEK4 Escherichia coli (strain K12) 4.7160592866736 5.22714285714286 21 33 4.76190476190476 Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (ENR) (EC 1.3.1.9) (NADH-dependent enoyl-ACP reductase) fabI envM b1288 JW1281 AOC3 O08590 Rattus norvegicus (Rat) 6.06666666666667 5.2875 3 3 0 Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (VP97) (Vascular adhesion protein 1) (VAP-1) Aoc3 CP2D6 P10635 Homo sapiens (Human) 3.10593337444826 5.3349632813361 2560 3076 16.5234375 Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) CYP2D6 CYP2DL1 NRAM P03470 Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1)) 6.12 6.36388888888889 3 4 0 Neuraminidase (EC 3.2.1.18) NA PTN11 P35235 Mus musculus (Mouse) 3.00436480540245 5.05 1 1 0 Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2) Ptpn11 SORT Q99523 Homo sapiens (Human) 5.47196897978274 5.10145833333333 9 9 0 Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) SORT1 GYRA P0AES4 Escherichia coli (strain K12) 4.80313843378868 5.20244117555455 58 154 3.44827586206897 DNA gyrase subunit A (EC 5.99.1.3) gyrA hisW nalA parD b2231 JW2225 GYRB P0AES6 Escherichia coli (strain K12) 4.80313843378868 5.20244117555455 58 154 3.44827586206897 DNA gyrase subunit B (EC 5.99.1.3) (Type IIA topoisomerase subunit GyrB) gyrB acrB cou himB hisU nalC parA pcbA b3699 JW5625 TTHY P02766 Homo sapiens (Human) 5.00047005703096 5.20323509485095 82 133 4.8780487804878 Transthyretin (ATTR) (Prealbumin) (TBPA) TTR PALB AGP1 P25376 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 5.12693679598431 5.05833333333333 3 3 33.3333333333333 General amino acid permease AGP1 (Asparagine/glutamine permease) AGP1 YCL025C YCL25C AAKG3 Q9UGI9 Homo sapiens (Human) 5.53323963995645 5.18011017628205 52 532 17.3076923076923 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3) PRKAG3 AMPKG3 ABL1 P00519 Homo sapiens (Human) 5.31869637440528 5.25666621177499 423 1004 2.83687943262411 Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) ABL1 ABL JTK7 LIPS P54310 Mus musculus (Mouse) 5 5.375 1 1 0 Hormone-sensitive lipase (HSL) (EC 3.1.1.79) Lipe LIPS P15304 Rattus norvegicus (Rat) 4.69740295639241 5.13885416666667 6 6 16.6666666666667 Hormone-sensitive lipase (HSL) (EC 3.1.1.79) Lipe MK09 P45984 Homo sapiens (Human) 4.45862536967433 5.26510589793056 330 452 2.72727272727273 Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) MAPK9 JNK2 PRKM9 SAPK1A AOC2 O75106 Homo sapiens (Human) 6.575 4.9825 1 4 0 Retina-specific copper amine oxidase (RAO) (EC 1.4.3.21) (Amine oxidase [copper-containing]) (Semicarbazide-sensitive amine oxidase) (SSAO) AOC2 M3K2 Q9Y2U5 Homo sapiens (Human) 5.6175 5.438125 8 9 0 Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) MAP3K2 MAPKKK2 MEKK2 RXFP1 Q9HBX9 Homo sapiens (Human) 4.59023932661692 5.31143819555144 609 698 22.3316912972085 Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1) RXFP1 LGR7 FABB P0A953 Escherichia coli (strain K12) 2.625 5.02875 8 8 0 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.41) (3-oxoacyl-[acyl-carrier-protein] synthase I) (Beta-ketoacyl-ACP synthase I) (KAS I) fabB fabC b2323 JW2320 MAP1 P0AE18 Escherichia coli (strain K12) 4.16826735093199 5.22630357142857 35 102 11.4285714285714 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) map b0168 JW0163 DPP4 P22411 Sus scrofa (Pig) 6.49111111111111 5.52666666666667 9 9 0 Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] DPP4 CD26 ANM8 Q9NR22 Homo sapiens (Human) 6.91 5.40625 2 2 0 Protein arginine N-methyltransferase 8 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4) PRMT8 HRMT1L3 HRMT1L4 DAPK1 P53355 Homo sapiens (Human) 4.79344399649813 5.22232305936073 73 132 17.8082191780822 Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK LYPL1 Q3UFF7 Mus musculus (Mouse) 5 5.375 1 1 0 Lysophospholipase-like protein 1 (EC 3.1.2.-) Lyplal1 STK36 Q9NRP7 Homo sapiens (Human) 4.88380648575113 5.30546296296296 9 13 11.1111111111111 Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) STK36 KIAA1278 MAP2 P50579 Homo sapiens (Human) 5.46620133251648 5.20007371794872 65 95 6.15384615384615 Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 MNPEP P67EIF2 ADA17 P78536 Homo sapiens (Human) 6.10458204639043 5.38755891667501 130 163 7.69230769230769 Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b) ADAM17 CSVP TACE PPARG P37231 Homo sapiens (Human) 4.60604280895998 5.28543514146001 369 1042 20.8672086720867 Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 F16P1 P09467 Homo sapiens (Human) 6.08716592219696 5.37949900793651 42 56 0 Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) FBP1 FBP AL1A2 O94788 Homo sapiens (Human) 2.20457574905607 5.245625 5 6 0 Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) ALDH1A2 RALDH2 NGF P01138 Homo sapiens (Human) 6 5.22916666666667 1 1 0 Beta-nerve growth factor (Beta-NGF) NGF NGFB NEUR4 Q8WWR8 Homo sapiens (Human) 2.86383832704045 4.90208333333333 3 4 0 Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) NEU4 LP5125 INAR1 P17181 Homo sapiens (Human) 2 5.38333333333333 3 3 0 Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) IFNAR1 IFNAR PAK1 Q13153 Homo sapiens (Human) 3.16783677691397 5.25546717171717 165 199 1.21212121212121 Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) PAK1 PDE6C P51160 Homo sapiens (Human) 5.3707378730961 5.464775 25 150 0 Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C) PDE6C PDEA2 VRK2 Q86Y07 Homo sapiens (Human) 5.83992919735282 5.14438725490196 34 53 26.4705882352941 Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2) VRK2 SGK1 O00141 Homo sapiens (Human) 4.77999848441647 5.2146204620462 101 158 10.8910891089109 Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1) SGK1 SGK SNRK Q9NRH2 Homo sapiens (Human) 5 5.37208333333333 6 6 0 SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK PTN5 P54829 Homo sapiens (Human) 3.82909702367155 5.30121323529412 34 34 26.4705882352941 Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) PTPN5 HD P42858 Homo sapiens (Human) 5.12710245977735 5.33576725459844 2468 2484 39.1410048622366 Huntingtin (Huntington disease protein) (HD protein) HTT HD IT15 ASNS P49088 Rattus norvegicus (Rat) 3.83894414920579 5.83437500000001 2 3 0 Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Glutamine-dependent asparagine synthetase) Asns GPR18 Q14330 Homo sapiens (Human) 4.39021315975 5.27964285714286 7 18 0 N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) GPR18 GPCRW ACPM P52505 Bos taurus (Bovine) 8.94183913391879 5.57403846153846 13 26 0 Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) NDUFAB1 M3K14 Q99558 Homo sapiens (Human) 7.31855882964801 5.22347697368421 76 89 0 Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) MAP3K14 NIK KCND3 Q9UK17 Homo sapiens (Human) 5.21214924816342 5.06333333333333 3 3 0 Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3) KCND3 GGT1 P19440 Homo sapiens (Human) 3.435 5.249375 4 4 0 Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] GGT1 GGT ST32A Q8WU08 Homo sapiens (Human) 5.10333333333333 5.37208333333333 6 6 0 Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1) STK32A YANK1 TBB4A P04350 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) TUBB4A TUBB4 TUBB5 DPYL2 O08553 Mus musculus (Mouse) 3.5 5.5075 4 4 0 Dihydropyrimidinase-related protein 2 (DRP-2) (Unc-33-like phosphoprotein 2) (ULIP-2) Dpysl2 Crmp2 Ulip2 ESYT1 Q3U7R1 Mus musculus (Mouse) 5 7.3625 1 4 0 Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) Esyt1 Fam62a Mbc2 ACRO P08001 Sus scrofa (Pig) 6.10333333333333 5.17916666666666 3 3 0 Acrosin (EC 3.4.21.10) (53 kDa fucose-binding protein) [Cleaved into: Acrosin light chain; Acrosin heavy chain] ACR AVR2B Q13705 Homo sapiens (Human) 4.90920026785133 5.38341666666667 10 13 10 Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) ACVR2B FER P16591 Homo sapiens (Human) 3.78670969038439 5.24465550595238 140 185 5.71428571428571 Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 GRIA1 P19490 Rattus norvegicus (Rat) 5.00612417794764 5.27362373737374 198 1022 0 Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) Gria1 Glur1 KDM4C Q9H3R0 Homo sapiens (Human) 4.84901171201041 5.28261261261261 37 126 16.2162162162162 Lysine-specific demethylase 4C (EC 1.14.11.-) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) KDM4C GASC1 JHDM3C JMJD2C KIAA0780 PANE P0A9J4 Escherichia coli (strain K12) 3.42829116819131 4.85 1 1 100 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reductase) (KPR) panE apbA b0425 JW0415 HPGDS O60760 Homo sapiens (Human) 5.77404623877335 5.53001302083333 16 19 6.25 Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 SFTPD P35247 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D) SFTPD COLEC7 PSPD SFTP4 G6PD P11413 Homo sapiens (Human) 3.46896946042984 5.27835901826484 73 73 20.5479452054795 Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6PD SCNNG P51170 Homo sapiens (Human) 2 4.85 1 3 100 Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) SCNN1G CCRL2 O00421 Homo sapiens (Human) 7.54333333333333 5.27260416666667 12 12 0 C-C chemokine receptor-like 2 (Chemokine receptor CCR11) (Chemokine receptor X) (Putative MCP-1 chemokine receptor) CCRL2 CCR11 CCR6 CKRX CRAM HCR FNTA P29702 Bos taurus (Bovine) 6.94071252645201 5.50091071428571 35 100 0 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA V1AR P30560 Rattus norvegicus (Rat) 7.29131933472896 5.12882352941177 17 47 0 Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) Avpr1a PSA7L Q8TAA3 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit alpha type-7-like (EC 3.4.25.1) PSMA8 PSMA7L CXCR1 P25024 Homo sapiens (Human) 2.9423430936984 5.27275556195346 108 218 25.9259259259259 C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181) CXCR1 CMKAR1 IL8RA ERR3 P62508 Homo sapiens (Human) 3.5 5.08235294117647 2 2 0 Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) ESRRG ERR3 ERRG2 KIAA0832 NR3B3 ST14 Q9Y5Y6 Homo sapiens (Human) 6.10232878268588 5.06990131578947 19 22 5.26315789473684 Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 ST17A Q9UEE5 Homo sapiens (Human) 4.47982450761371 5.21548720472441 127 149 7.08661417322835 Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) STK17A DRAK1 RAD52 P43351 Homo sapiens (Human) 5.01108186808166 5.174375 46 46 4.34782608695652 DNA repair protein RAD52 homolog RAD52 DYR P00376 Bos taurus (Bovine) 5.03058823529412 5.15698887274032 17 17 0 Dihydrofolate reductase (EC 1.5.1.3) DHFR ANT3 P41361 Bos taurus (Bovine) 2 5.0875 1 1 0 Antithrombin-III (ATIII) (Serpin C1) SERPINC1 AT3 CATL1 P25975 Bos taurus (Bovine) 5.77875 5.01375 8 8 0 Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] CTSL CTSL1 KPB1 P46020 Homo sapiens (Human) 6.44675833482469 5.26255208333333 4 20 0 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) PHKA1 PHKA CAC1S Q13698 Homo sapiens (Human) 7.31290402075269 5.32762120786137 10 48 0 Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1) CACNA1S CACH1 CACN1 CACNL1A3 DPP4 P14740 Rattus norvegicus (Rat) 4.1405894342272 5.1965625 11 11 0 Dipeptidyl peptidase 4 (EC 3.4.14.5) (Bile canaliculus domain-specific membrane glycoprotein) (Dipeptidyl peptidase IV) (DPP IV) (GP110 glycoprotein) (T-cell activation antigen CD26) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form); Dipeptidyl peptidase 4 60 kDa soluble form (Dipeptidyl peptidase IV 60 kDa soluble form)] Dpp4 Cd26 PTPRB P23467 Homo sapiens (Human) 4.45242609748269 5.40271739130435 23 23 0 Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) PTPRB PTPB POLG P27958 Hepatitis C virus genotype 1a (isolate H) (HCV) 4.804828334056 5.405 6 6 0 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] FYN P06241 Homo sapiens (Human) 3.47444221384168 5.25491735856381 306 448 11.437908496732 Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) FYN GRM6 O15303 Homo sapiens (Human) 4.55385531256175 5.33501799242424 55 79 3.63636363636364 Metabotropic glutamate receptor 6 (mGluR6) GRM6 GPRC1F MGLUR6 DPO3 P0C1P9 Staphylococcus aureus 5.39439972831135 5.09375 2 4 0 DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC ERBB4 Q15303 Homo sapiens (Human) 3.64693142075742 5.24402059925094 178 249 4.49438202247191 Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)] ERBB4 HER4 ASAH2 Q9NR71 Homo sapiens (Human) 4.14399469741737 5.66535984316004 4 6 0 Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form] ASAH2 HNAC1 DRD1 Q95136 Bos taurus (Bovine) 5.03459400350976 5.35035218253968 21 69 0 D(1A) dopamine receptor (Dopamine D1 receptor) DRD1 D1AR Q0PJ46 Q0PJ46 Plasmodium falciparum 3.61798295742513 5.15 1 1 0 Lactate dehydrogenase LDH PKNB P9WI81 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.946 5.358 10 10 0 Serine/threonine-protein kinase PknB (EC 2.7.11.1) pknB Rv0014c MTCY10H4.14c PARE P0C1S7 Staphylococcus aureus 5.02323191726949 5.35357142857143 7 14 0 DNA topoisomerase 4 subunit B (EC 5.99.1.3) (Topoisomerase IV subunit B) parE grlB DGLA Q9Y4D2 Homo sapiens (Human) 5.62 5.90729166666667 6 6 0 Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator) DAGLA C11orf11 KIAA0659 NSDDR KCS2 Q5XEP9 Arabidopsis thaliana (Mouse-ear cress) 2 5.05 2 2 0 3-ketoacyl-CoA synthase 2 (KCS-2) (EC 2.3.1.199) (Docosanoic acid synthase) (Very long-chain fatty acid condensing enzyme 2) (VLCFA condensing enzyme 2) KCS2 DAISY KCS17 At1g04220 F20D22.1 MOGT2 Q3SYC2 Homo sapiens (Human) 6.90625 5.2790625 4 5 0 2-acylglycerol O-acyltransferase 2 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2) (MGAT2) (hMGAT2) (Diacylglycerol O-acyltransferase candidate 5) (hDC5) (Diacylglycerol acyltransferase 2-like protein 5) (Monoacylglycerol O-acyltransferase 2) MOGAT2 DC5 DGAT2L5 PARC P0C1U9 Staphylococcus aureus 4.93726234208864 5.23375 10 17 0 DNA topoisomerase 4 subunit A (EC 5.99.1.3) (Topoisomerase IV subunit A) parC grlA CCR9 P51686 Homo sapiens (Human) 6.67 4.9125 1 1 0 C-C chemokine receptor type 9 (C-C CKR-9) (CC-CKR-9) (CCR-9) (G-protein coupled receptor 28) (GPR-9-6) (CD antigen CDw199) CCR9 GPR28 CECR2 Q9BXF3 Homo sapiens (Human) 4.02 5.03033333333333 5 5 0 Cat eye syndrome critical region protein 2 CECR2 KIAA1740 SSN3 P39073 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 3.30102999566398 4.95 1 1 0 Meiotic mRNA stability protein kinase SSN3 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin-dependent kinase 8) (Suppressor of RNA polymerase B SRB10) SSN3 ARE1 CDK8 GIG2 SRB10 UME5 YPL042C LYAG P10253 Homo sapiens (Human) 4.77721056182894 5.32725981447324 3573 5656 31.6820598936468 Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] GAA R1AB P0C6X7 Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) 4.43235333044265 5.04034722222222 6 11 0 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like proteinase (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.69) (Non-structural protein 3) (nsp3) (PL2-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13); Guanine-N7 methyltransferase (ExoN) (EC 2.1.1.-) (EC 3.1.13.-) (nsp14); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15); 2'-O-methyltransferase (EC 2.1.1.-) (nsp16)] rep 1a-1b R1A P0C6U8 Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) 4.61745350892472 5.18253472222222 30 32 3.33333333333333 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)] 1a RET P07949 Homo sapiens (Human) 4.64272456604711 5.25645956153127 239 426 4.18410041841004 Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] RET CDHF12 CDHR16 PTC RET51 Q932Y6 Q932Y6 Pseudomonas aeruginosa 4.29716498737054 5.21690746722819 70 87 11.4285714285714 Beta-lactamase (EC 3.5.2.6) bla(tem-2) bla ENTP3 O75355 Homo sapiens (Human) 4.22184874961636 4.9125 1 1 0 Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6) ENTPD3 CD39L3 ULK3 Q3U3Q1 Mus musculus (Mouse) 4.14 5.25138888888889 3 3 33.3333333333333 Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) Ulk3 CATB P07688 Bos taurus (Bovine) 5.72247222605267 5.16443055555555 15 19 0 Cathepsin B (EC 3.4.22.1) (BCSB) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB CATC Q3ZCJ8 Bos taurus (Bovine) 4 4.825 1 1 0 Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC Q7CIL8 Q7CIL8 Yersinia pestis 4.36041199826559 5.04125 5 5 0 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) supX topA YPO2218 DCLK3 Q9C098 Homo sapiens (Human) 5.11326640549231 5.36074074074074 9 11 11.1111111111111 Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 SIK3 Q9Y2K2 Homo sapiens (Human) 5.52142857142857 5.38857142857143 7 8 0 Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) SIK3 KIAA0999 QSK L19 MANBA Q4FZV0 Rattus norvegicus (Rat) 4.39794000867204 5.040625 2 2 0 Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) Manba ACRO P10323 Homo sapiens (Human) 5.20791045929864 5.29194951415989 12 16 0 Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] ACR ACRS ACKR3 P25106 Homo sapiens (Human) 6.52287874528034 4.95 1 1 0 Atypical chemokine receptor 3 (C-X-C chemokine receptor type 7) (CXC-R7) (CXCR-7) (Chemokine orphan receptor 1) (G-protein coupled receptor 159) (G-protein coupled receptor RDC1 homolog) (RDC-1) ACKR3 CMKOR1 CXCR7 GPR159 RDC1 GTR1 P11166 Homo sapiens (Human) 3.64866573836304 5.28796765784164 632 661 0.791139240506329 Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter) SLC2A1 GLUT1 Q4GZG4 Q4GZG4 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 5.01478819292184 5.46221986607143 112 112 48.2142857142857 Phosphoglycerate kinase (EC 2.7.2.3) PGKC TB927.1.700 MYLK Q15746 Homo sapiens (Human) 5.39553131997266 5.1589465408805 53 83 18.8679245283019 Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] MYLK MLCK MLCK1 MYLK1 LONM Q8CGK3 Mus musculus (Mouse) 5 5.375 1 1 0 Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) Lonp1 Prss15 BRSK2 Q8IWQ3 Homo sapiens (Human) 4.63827134992821 5.23286029411765 85 138 10.5882352941176 Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 ACLY P53396 Homo sapiens (Human) 4.95785984316004 5.693125 8 8 0 ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme) ACLY ARBK2 P35626 Homo sapiens (Human) 4.04575749056067 5 1 1 0 Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) GRK3 ADRBK2 BARK2 NAAA Q02083 Homo sapiens (Human) 4 5.25 2 2 0 N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] NAAA ASAHL PLT AT1A3 P13637 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 3.6.3.9) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) ATP1A3 B4GT1 P08037 Bos taurus (Bovine) 3.61215080843531 5.540625 4 5 0 Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)] B4GALT1 GALT GGTB2 B4GT1 P15291 Homo sapiens (Human) 4.20812160180082 5.2875 3 3 0 Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)] B4GALT1 GGTB2 BRPF1 P55201 Homo sapiens (Human) 4.16666666666667 5.2653125 6 18 0 Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 CAC1D Q01668 Homo sapiens (Human) 7.04445820068426 5.31791321926791 11 49 0 Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3) CACNA1D CACH3 CACN4 CACNL1A2 CCHL1A2 CAH6 P23280 Homo sapiens (Human) 5.50208067790922 5.230375 45 158 4.44444444444444 Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) CA6 CBP Q92793 Homo sapiens (Human) 4.94699114207616 5.3287256487421 35 132 25.7142857142857 CREB-binding protein (EC 2.3.1.48) CREBBP CBP EHMT2 Q96KQ7 Homo sapiens (Human) 4.73187411772336 5.33061228857738 12587 12793 23.6275522364344 Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) EHMT2 BAT8 C6orf30 G9A KMT1C NG36 FOLR2 P14207 Homo sapiens (Human) 6.07611111111111 5.18916666666666 3 8 0 Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP) FOLR2 FOXO1 Q12778 Homo sapiens (Human) 4.82390874094432 4.8125 1 1 100 Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) FOXO1 FKHR FOXO1A GBRG2 P18507 Homo sapiens (Human) 6.56399358592744 5.20930839201878 142 1767 1.40845070422535 Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) GABRG2 MOGS Q13724 Homo sapiens (Human) 3.00436480540245 5.275 1 1 0 Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Processing A-glucosidase I) MOGS GCS1 GLRA1 P23415 Homo sapiens (Human) 4 5.125 5 7 0 Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) GLRA1 GRB7 Q14451 Homo sapiens (Human) 5.43 4.95 1 2 0 Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein) GRB7 GRIA1 P42261 Homo sapiens (Human) 5.62748011423893 5.43472916666666 20 50 0 Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) GRIA1 GLUH1 GLUR1 HXK1 P19367 Homo sapiens (Human) 3.3457791372216 5.25085038363171 23 23 21.7391304347826 Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I) HK1 LEPR P48357 Homo sapiens (Human) 2 5.375 1 2 0 Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) LEPR DB OBR MPIP3 P30307 Homo sapiens (Human) 4.75213269437895 5.26469618438168 19 23 0 M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) CDC25C NEK9 Q8TD19 Homo sapiens (Human) 4.01200383521305 5.30290104166667 40 70 2.5 Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) NEK9 KIAA1995 NEK8 NERCC NFKB2 Q00653 Homo sapiens (Human) 5.20545595489164 5.27834802375548 821 4185 84.4092570036541 Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] NFKB2 LYT10 P2RX4 Q99571 Homo sapiens (Human) 4.62315405764173 5.31610119047619 14 26 0 P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 PASK Q96RG2 Homo sapiens (Human) 4.32918563821251 5.22408564814815 54 75 9.25925925925926 PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) PASK KIAA0135 PDE4A P27815 Homo sapiens (Human) 5.81275895276529 5.29766957417677 212 861 0.471698113207547 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) PDE4A DPDE2 PORCN Q9H237 Homo sapiens (Human) 7.93 5.04583333333333 3 3 0 Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.-) (Protein MG61) PORCN MG61 PORC PPN PSB4 P28070 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) PSMB4 PROS26 S28A2 O43868 Homo sapiens (Human) 3.90708213301572 4.95 1 3 0 Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2) SLC28A2 CNT2 SF3B3 Q15393 Homo sapiens (Human) 6.04013818129432 5.85 1 3 100 Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) SF3B3 KIAA0017 SAP130 SMCA4 P51532 Homo sapiens (Human) 4.7 4.9975 1 1 0 Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) SMARCA4 BAF190A BRG1 SNF2B SNF2L4 SRBP2 Q12772 Homo sapiens (Human) 4.934 5.245 5 5 0 Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2] SREBF2 BHLHD2 SREBP2 SUZ12 Q15022 Homo sapiens (Human) 5.32 4.92708333333333 1 3 0 Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) SUZ12 CHET9 JJAZ1 KIAA0160 TAOK2 Q9UL54 Homo sapiens (Human) 5.56872836037454 5.10349404761905 35 51 25.7142857142857 Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2) TAOK2 KIAA0881 MAP3K17 PSK PSK1 UNQ2971/PRO7431 TPH1 P17752 Homo sapiens (Human) 6.51666666666667 5.00916666666667 3 3 0 Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) TPH1 TPH TPRH TRPH TXK P42681 Homo sapiens (Human) 4.7750753189197 5.21765625 72 129 13.8888888888889 Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase) TXK PTK4 RLK M3K15 Q6ZN16 Homo sapiens (Human) 5.08571428571429 5.38857142857143 7 8 0 Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 PAR10 Q53GL7 Homo sapiens (Human) 4.558621250542 5.12684895833333 8 12 0 Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 PARP6 Q2NL67 Homo sapiens (Human) 3.5 4.9578125 2 2 0 Poly [ADP-ribose] polymerase 6 (PARP-6) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) PARP6 TRPA1 O75762 Homo sapiens (Human) 5.21785646497957 5.23400462962963 36 44 2.77777777777778 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) TRPA1 ANKTM1 NR1I3 Q14994 Homo sapiens (Human) 2 6.30875 1 2 0 Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67) NR1I3 CAR KDM5C P41229 Homo sapiens (Human) 5.28181818181818 5.23047348484848 11 24 0 Lysine-specific demethylase 5C (EC 1.14.11.-) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) KDM5C DXS1272E JARID1C SMCX XE169 PRO P10274 Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) 6.62432740962937 4.94807692307692 13 16 0 Gag-Pro polyprotein (Pr76Gag-Pro) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Transframe peptide (TFP) (p8)] gag-pro prt ADCY2 Q08462 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 ADCY3 O60266 Homo sapiens (Human) 7.15 4.8125 1 9 0 Adenylate cyclase type 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3) ADCY3 KIAA0511 ADCY5 O95622 Homo sapiens (Human) 4.7814473554148 5.33310858585859 15 25 0 Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ADCY5 KIF23 Q02241 Homo sapiens (Human) 2.28687439984119 5.09458333333333 6 6 0 Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) KIF23 KNSL5 MKLP1 MP2K5 Q13163 Homo sapiens (Human) 5.36976645556927 5.40340909090909 11 13 9.09090909090909 Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) MAP2K5 MEK5 MKK5 PRKMK5 P85A P27986 Homo sapiens (Human) 6.02194678672977 5.12146464646465 22 118 4.54545454545455 Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) PIK3R1 GRB1 PANK2 Q9BZ23 Homo sapiens (Human) 7.04 5.2375 1 1 0 Pantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) PANK2 C20orf48 PEPA P00791 Sus scrofa (Pig) 5.8293813263856 5.35659895833333 40 42 0 Pepsin A (EC 3.4.23.1) PGA CAH3 Q3SZX4 Bos taurus (Bovine) 4.99988825233613 5.375125 25 183 0 Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) CA3 NANOG Q9H9S0 Homo sapiens (Human) 5 4.9 1 1 0 Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog) NANOG HMDH P51639 Rattus norvegicus (Rat) 6.72636903786013 5.27008541573265 54 82 0 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) Hmgcr MYLK4 Q86YV6 Homo sapiens (Human) 5.25 5.36768518518518 9 12 11.1111111111111 Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085) MYLK4 SGK085 MA2B1 O00754 Homo sapiens (Human) 3.00436480540245 5.275 1 1 0 Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] MAN2B1 LAMAN MANB ACACA Q13085 Homo sapiens (Human) 6.18910099874142 5.08204040262046 15 19 0 Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACACA ACAC ACC1 ACCA CO3 P01024 Homo sapiens (Human) 6.79666666666667 4.95 6 12 0 Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] C3 CPAMD1 UNG P13051 Homo sapiens (Human) 4.13505102171204 5.31666666666667 6 6 0 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG DGU UNG1 UNG15 PP2AA P67775 Homo sapiens (Human) 3 6.1 1 1 0 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) PPP2CA HSP82 P02829 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.24667233334139 4.925 1 1 0 ATP-dependent molecular chaperone HSP82 (82 kDa heat shock protein) (Heat shock protein Hsp90 heat-inducible isoform) HSP82 HSP90 YPL240C AURKA O14965 Homo sapiens (Human) 5.34705104719274 5.26746761744788 541 612 1.84842883548983 Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 INSR P06213 Homo sapiens (Human) 3.97512646105699 5.25031818288543 288 381 3.47222222222222 Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] INSR NOX3 Q9HBY0 Homo sapiens (Human) 5.12 4.81666666666667 1 1 0 NADPH oxidase 3 (EC 1.6.3.-) (Mitogenic oxidase 2) (MOX-2) (gp91phox homolog 3) (GP91-3) NOX3 MOX2 SMCA2 P51531 Homo sapiens (Human) 4.0618674326124 5.14039802631579 38 38 42.1052631578947 Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) SMARCA2 BAF190B BRM SNF2A SNF2L2 S1PR3 Q99500 Homo sapiens (Human) 5.78455377998091 5.27930345117845 99 124 1.01010101010101 Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3) S1PR3 EDG3 CLK1 P49759 Homo sapiens (Human) 5.57182922545043 5.2889224137931 87 90 8.04597701149425 Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) CLK1 CLK TSHR P16473 Homo sapiens (Human) 4.85173820317499 5.39936324236134 2574 8908 31.8181818181818 Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R) TSHR LGR3 BKRB1 P46663 Homo sapiens (Human) 7.10991969511833 5.24644503546099 47 55 0 B1 bradykinin receptor (B1R) (BK-1 receptor) BDKRB1 BRADYB1 NOD2 Q9HC29 Homo sapiens (Human) 4.51820435758237 5.19232799369748 68 83 8.82352941176471 Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1) NOD2 CARD15 IBD1 IMA1 P52292 Homo sapiens (Human) 4.67666666666667 5.42916666666667 3 3 0 Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) KPNA2 RCH1 SRP1 AA1R P30542 Homo sapiens (Human) 5.22186336922231 5.2438433867558 681 975 4.55212922173275 Adenosine receptor A1 ADORA1 DRD5 P21918 Homo sapiens (Human) 4.36934343289806 5.29718316186035 34 62 5.88235294117647 D(1B) dopamine receptor (D(5) dopamine receptor) (D1beta dopamine receptor) (Dopamine D5 receptor) DRD5 DRD1B DRD1L2 5HT1D P28221 Homo sapiens (Human) 6.99619105548055 5.38728409090909 110 215 0 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D) HTR1D HTR1DA HTRL SENP7 Q9BQF6 Homo sapiens (Human) 5.17054738460043 5.21171859221041 310 344 44.5161290322581 Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) SENP7 KIAA1707 SSP2 SUSP2 TPO P40225 Homo sapiens (Human) 5.49433962264151 5.39190710716367 53 106 45.2830188679245 Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand) THPO MGDF MPEG1 Q2M385 Homo sapiens (Human) 5.24713539202096 5.215625 4 8 0 Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 KPCT Q9WTQ0 Rattus norvegicus (Rat) 5.78977284953525 5.17996376811594 23 216 4.34782608695652 Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta) Prkcq Pkcq GABT P50554 Rattus norvegicus (Rat) 5.81497293476011 5.225125 5 6 20 4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform] Abat Gabat GLCM Q2KHZ8 Bos taurus (Bovine) 4.54 6.2875 1 1 0 Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) GBA FUCO Q2KIM0 Bos taurus (Bovine) 4.18093050424527 5.28576388888889 6 6 0 Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 RISB P9WHE9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.18651686562463 5.55416666666667 3 9 0 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) ribH Rv1416 MTCY21B4.34 FOLH1 Q04609 Homo sapiens (Human) 6.5095719519287 5.53228787843289 60 83 0 Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) FOLH1 FOLH NAALAD1 PSM PSMA GIG27 HCD2 Q99714 Homo sapiens (Human) 4.48553613644038 5.37307508067282 3102 4229 34.461637653127 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2 CLTR1 Q2NNR5 Cavia porcellus (Guinea pig) 5.92050066962833 5.373125 4 4 0 Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) CYSLTR1 ACHA5 Q2MKA5 Mus musculus (Mouse) 8.25 4.85 1 9 0 Neuronal acetylcholine receptor subunit alpha-5 Chrna5 S22A8 O88909 Mus musculus (Mouse) 5.27842220491851 5.42500000000003 1 1 0 Solute carrier family 22 member 8 (Organic anion transporter 3) (mOat3) (Reduced in osteosclerosis transporter) Slc22a8 Oat3 Roct AMPL P28838 Homo sapiens (Human) 3.93782014905637 5.12272058823529 17 18 0 Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 LAPEP PEPS RORB Q92753 Homo sapiens (Human) 4.920992501084 5.12767992158001 4 5 0 Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) RORB NR1F2 RZRB AOFA P21398 Bos taurus (Bovine) 6.05080903292982 5.34887185534591 53 57 3.77358490566038 Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) MAOA AOFB P56560 Bos taurus (Bovine) 4.33668507612851 5.30616161616162 33 36 9.09090909090909 Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) MAOB AOFB P19643 Rattus norvegicus (Rat) 4.69044475634913 5.17564349473759 143 176 1.3986013986014 Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) Maob ATS1 Q9UHI8 Homo sapiens (Human) 2 5.6025 2 2 0 A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1) ADAMTS1 KIAA1346 METH1 SCNBA Q9UI33 Homo sapiens (Human) 5.44 5.52287874528033 1 10 0 Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN) SCN11A SCN12A SNS2 ITB2 P05107 Homo sapiens (Human) 5.1700246633734 5.40173387096774 31 137 0 Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 MFI7 KCNN1 Q92952 Homo sapiens (Human) 7.23 5.25958333333333 3 3 0 Small conductance calcium-activated potassium channel protein 1 (SK1) (SKCa 1) (SKCa1) (KCa2.1) KCNN1 SK KNG1 P01042 Homo sapiens (Human) 9.145 5.25 1 2 0 Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] KNG1 BDK KNG MARK1 Q9P0L2 Homo sapiens (Human) 4.59542567533883 5.26132942708334 80 140 12.5 Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c) MARK1 KIAA1477 MARK A2RP81 A2RP81 Citrobacter freundii 7.22 5.4 1 1 0 Beta-lactamase (EC 3.5.2.6) blaPER-2 KLF5 Q13887 Homo sapiens (Human) 5.93669994879706 5.32816532258065 31 31 41.9354838709677 Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) KLF5 BTEB2 CKLF IKLF CDPK4 Q8IBS5 Plasmodium falciparum (isolate 3D7) 6.11424953477803 5.23589814814815 45 45 4.44444444444444 Calcium-dependent protein kinase 4 (EC 2.7.11.1) CPK4 CDPK4 PF07_0072 Q25917 Q25917 Plasmodium falciparum 6 5.24701013513514 37 37 5.40540540540541 Mitogen-activated protein kinase (EC 2.7.11.24) map-2 Q8IL88 Q8IL88 Plasmodium falciparum (isolate 3D7) 5.38155644516513 5.24027889784946 62 62 37.0967741935484 HSP40, subfamily A, putative PF14_0359 PF3D7_1437900 Q8IL32 Q8IL32 Plasmodium falciparum (isolate 3D7) 5.55958418452597 5.24883785140562 83 83 18.0722891566265 HSP90 (Heat shock protein 90, putative) PF14_0417 PF3D7_1443900 A3EZJ3 A3EZJ3 Hepatitis C virus 4.54922925621352 5.40028284749322 12 12 16.6666666666667 Genome polyprotein (Fragment) NS3 AT1B2 P14415 Homo sapiens (Human) 5.72547979088005 5.63118055555556 12 180 0 Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2) ATP1B2 EZRI P15311 Homo sapiens (Human) 4.86 5.57125 2 2 0 Ezrin (Cytovillin) (Villin-2) (p81) EZR VIL2 GLUC P01275 Homo sapiens (Human) 6.61 5.27 5 5 0 Glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)] GCG ITB3 P05106 Homo sapiens (Human) 7.08961523046647 5.3382077695777 271 840 0 Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) ITGB3 GP3A KISSR Q969F8 Homo sapiens (Human) 7.83097162029546 5.08059523809523 63 90 0 KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor) KISS1R AXOR12 GPR54 LOX12 P18054 Homo sapiens (Human) 4.73512186457329 5.35815877152915 411 431 40.632603406326 Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) ALOX12 12LO LOG12 BLA1 P52700 Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia) 5.18709110493005 5.83874094202899 46 66 0 Metallo-beta-lactamase L1 type 3 (EC 3.5.2.6) (B3 metallo-beta-lactamase) (Beta-lactamase type III) (Metallo-beta-lactamase L1 type III) (Penicillinase) ACHG P07510 Homo sapiens (Human) 3.98886257138916 5.27889660493827 27 172 0 Acetylcholine receptor subunit gamma CHRNG ACHRG GBRA2 P47869 Homo sapiens (Human) 6.33740879991526 5.19848798798799 111 1272 0.900900900900901 Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) GABRA2 GBRA6 Q16445 Homo sapiens (Human) 5.92461111497333 5.22730842911877 87 1298 1.14942528735632 Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) GABRA6 GSTA2 P09210 Homo sapiens (Human) 4.48 6.3375 1 1 0 Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2) GSTA2 GST2 KMO O15229 Homo sapiens (Human) 6.585625 5.44090604207317 16 27 0 Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) KMO TEC P42680 Homo sapiens (Human) 4.77735091510186 5.23080314009662 69 126 14.4927536231884 Tyrosine-protein kinase Tec (EC 2.7.10.2) TEC PSCTK4 HDAC4 Q99P99 Rattus norvegicus (Rat) 5.32433877356746 5.17291666666667 2 28 0 Histone deacetylase 4 (HD4) (EC 3.5.1.98) Hdac4 LGUL Q04760 Homo sapiens (Human) 5.21102051699057 5.39547619047619 7 11 42.8571428571429 Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) GLO1 CAH3 P07451 Homo sapiens (Human) 5.0945067468223 5.19581896551724 29 140 3.44827586206897 Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) CA3 PB2 P03428 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 6.4 5.075 1 1 0 Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3) PB2 DDAH1 O94760 Homo sapiens (Human) 4.79188481588103 5.0571875 8 18 12.5 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1) DDAH1 DDAH LEG3 P17931 Homo sapiens (Human) 3.8148215433273 5.48 7 8 0 Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) LGALS3 MAC2 PDE10 Q9QYJ6 Rattus norvegicus (Rat) 7.09234042553191 5.19894019941787 47 51 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35) Pde10a GBA2 Q9HCG7 Homo sapiens (Human) 7.19615384615385 5.36827391050657 13 13 0 Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) GBA2 KIAA1605 AD035 GBA2 Q69ZF3 Mus musculus (Mouse) 5 4.91875 2 2 0 Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) Gba2 Kiaa1605 HEMA P03452 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 7.62 4.95 2 2 0 Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain] HA AMPN P15144 Homo sapiens (Human) 4.77659201137608 5.33756294326241 47 59 2.12765957446809 Aminopeptidase N (AP-N) (hAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13) ANPEP APN CD13 PEPN GBRA4 P20237 Bos taurus (Bovine) 5.71296550559005 5.10841561928071 48 378 0 Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) GABRA4 GRK4 P32298 Homo sapiens (Human) 5.5675 5.3946875 8 9 0 G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1) GRK4 GPRK2L GPRK4 ITAV P06756 Homo sapiens (Human) 7.00582750835473 5.26877003205129 156 495 0 Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] ITGAV MSK8 VNRA VTNR KIF5A Q12840 Homo sapiens (Human) 4.30102999566398 5.4375 1 1 0 Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) KIF5A NKHC1 PDE3B Q13370 Homo sapiens (Human) 5.53978457365957 5.30474242032743 183 460 0.546448087431694 cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) PDE3B RIOK2 Q9BVS4 Homo sapiens (Human) 5.21687792459799 5.4725 8 9 0 Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) RIOK2 SENP2 Q9HC62 Homo sapiens (Human) 5 5.1375 1 1 0 Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 TRPM8 Q7Z2W7 Homo sapiens (Human) 4.35928571428571 5.113125 7 9 0 Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 VGFR1 P17948 Homo sapiens (Human) 4.08063356655971 5.24686487559926 368 567 8.96739130434783 Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) FLT1 FLT FRT VEGFR1 NRAM P03469 Influenza A virus (strain A/USSR/90/1977 H1N1) 6.93 5.5625 1 3 0 Neuraminidase (EC 3.2.1.18) NA MYO3A Q8NEV4 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Myosin-IIIa (EC 2.7.11.1) MYO3A BHMT1 Q93088 Homo sapiens (Human) 4.86541446425558 4.99722222222222 9 13 0 Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) BHMT CSKP O14936 Homo sapiens (Human) 5.36333333333333 5.37208333333333 6 6 0 Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 DVL1 O14640 Homo sapiens (Human) 3.49013040978365 5.32972222222222 3 7 0 Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) DVL1 KCNK2 O95069 Homo sapiens (Human) 5 4.98666666666667 3 3 0 Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1) KCNK2 TREK TREK1 LCAP Q9UIQ6 Homo sapiens (Human) 5.05515993029335 5.39989583333333 18 19 5.55555555555556 Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form] LNPEP OTASE LIPS Q05469 Homo sapiens (Human) 6.33990394635101 5.10858796296296 9 12 0 Hormone-sensitive lipase (HSL) (EC 3.1.1.79) LIPE PPBN P10696 Homo sapiens (Human) 3.96109237241448 5.354847004019 119 175 29.4117647058824 Alkaline phosphatase, placental-like (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like) ALPPL2 ALPPL HDAH Q70I53 Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) 3.345 5.5125 3 4 33.3333333333333 Histone deacetylase-like amidohydrolase (HDAC-like amidohydrolase) (HDAH) (EC 3.5.1.-) hdaH hdaH1 TIE2 Q02763 Homo sapiens (Human) 5.13590885985361 5.26455704365079 140 209 6.42857142857143 Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 ADAL Q6DHV7 Homo sapiens (Human) 3.87742907816419 5.105 5 5 0 Adenosine deaminase-like protein (EC 3.5.4.-) ADAL TDT P06526 Bos taurus (Bovine) 3.69897000433602 5.1 1 1 0 DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (TDT) (Terminal transferase) DNTT TDT ACHA7 Q05941 Rattus norvegicus (Rat) 6.25951507659579 5.29271318389148 175 930 0 Neuronal acetylcholine receptor subunit alpha-7 Chrna7 Acra7 BGLR P08236 Homo sapiens (Human) 4.76528963498507 5.2421580006504 10 13 0 Beta-glucuronidase (EC 3.2.1.31) (Beta-G1) GUSB CD36 Q07969 Rattus norvegicus (Rat) 4.87333333333333 4.9475 15 15 0 Platelet glycoprotein 4 (Adipocyte membrane protein) (Fatty acid translocase) (Fatty acid transport protein) (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36) Cd36 Fat CP1A2 P04799 Rattus norvegicus (Rat) 6.07445648330566 5.121875 3 11 0 Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P-448) (Cytochrome P-450d) (Cytochrome P450-D) Cyp1a2 Cyp1a-2 CPT1A P32198 Rattus norvegicus (Rat) 4.66143937264017 4.89375 2 2 0 Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A) Cpt1a Cpt-1 Cpt1 KCNA5 P22460 Homo sapiens (Human) 5.08851853623344 5.40957589285714 28 34 0 Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) KCNA5 MA2A1 Q16706 Homo sapiens (Human) 4.33972222579867 5.41875 2 2 0 Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) MAN2A1 MANA2 NF2L2 O54968 Rattus norvegicus (Rat) 5 5.16875 1 5 0 Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) Nfe2l2 Nrf2 PA1B2 Q61206 Mus musculus (Mouse) 5 5.375 1 1 0 Platelet-activating factor acetylhydrolase IB subunit beta (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) Pafah1b2 Pafahb PPBT P09487 Bos taurus (Bovine) 5.871730337221 5.38513020833333 4 8 0 Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) ALPL S22A4 Q9H015 Homo sapiens (Human) 5.66101395828026 4.95625 2 2 0 Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (Organic cation/carnitine transporter 1) SLC22A4 ETT OCTN1 UT2H KAPCA P17612 Homo sapiens (Human) 4.37338693852418 5.24121429095978 357 631 3.0812324929972 cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) PRKACA PKACA CAH1 P00915 Homo sapiens (Human) 6.16923402638909 5.30189165659744 579 787 1.20898100172712 Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) CA1 CD38 P28907 Homo sapiens (Human) 4.5309072571292 5.40534090909091 11 13 18.1818181818182 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD antigen CD38) CD38 AAK1 Q2M2I8 Homo sapiens (Human) 5.65693348600513 5.31992424242424 11 17 9.09090909090909 AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 KIAA1048 PLCB3 Q01970 Homo sapiens (Human) 3.93341017283762 5.10953125 16 16 18.75 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) PLCB3 CD11A Q9UQ88 Homo sapiens (Human) 5.06 5.36768518518518 9 12 11.1111111111111 Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) CDK11A CDC2L2 CDC2L3 PITSLREB FTO Q9C0B1 Homo sapiens (Human) 4.60648727081361 5.245625 4 6 0 Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.-) (Fat mass and obesity-associated protein) FTO KIAA1752 ATP4A P20648 Homo sapiens (Human) 5.09497503363115 5.25993827160494 27 164 0 Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) ATP4A CLK3 O35492 Mus musculus (Mouse) 5.21333333333333 5.33208333333333 6 6 0 Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) Clk3 DYRK2 Q92630 Homo sapiens (Human) 4.9818235106008 5.22792939814815 90 144 11.1111111111111 Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 GRM2 P31421 Rattus norvegicus (Rat) 4.60008716795125 5.44123511904762 70 120 1.42857142857143 Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 ADA1A P43140 Rattus norvegicus (Rat) 5.32295864861843 5.30648783136225 297 897 9.09090909090909 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) Adra1a Adra1c MURD P14900 Escherichia coli (strain K12) 5.19592864069245 5.27390625 4 6 0 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) murD b0088 JW0086 ACE P12821 Homo sapiens (Human) 6.32911834296567 5.40600861396996 95 139 0 Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] ACE DCP DCP1 MAPK2 P49137 Homo sapiens (Human) 4.33058191337665 5.24963437201528 349 436 3.15186246418338 MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) MAPKAPK2 NLK Q9UBE8 Homo sapiens (Human) 5.50451699151045 5.17150914634146 41 62 21.9512195121951 Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) NLK LAK1 MMP9 P14780 Homo sapiens (Human) 5.04320707009231 5.31332944078053 343 471 8.45481049562682 Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] MMP9 CLG4B UBP7 Q93009 Homo sapiens (Human) 6.38 5.45 2 2 0 Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 HAUSP DYRK3 O43781 Homo sapiens (Human) 4.16368359838584 5.20662334983498 101 103 3.96039603960396 Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) (Regulatory erythroid kinase) (REDK) DYRK3 TNNI3 P19429 Homo sapiens (Human) 4.62783757783353 5.38527546296296 30 90 43.3333333333333 Troponin I, cardiac muscle (Cardiac troponin I) TNNI3 TNNC1 SIR5 Q9NXA8 Homo sapiens (Human) 4.42643890264034 5.19825268817204 31 32 3.2258064516129 NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5) SIRT5 SIR2L5 DHSO P27867 Rattus norvegicus (Rat) 5.54525022162094 6.0375 2 2 0 Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) Sord Sdh1 ERG P11308 Homo sapiens (Human) 4.77892235709807 5.27318340417514 734 782 18.3923705722071 Transcriptional regulator ERG (Transforming protein ERG) ERG P3C2A O00443 Homo sapiens (Human) 5.69472115853237 5.25754166666667 10 10 10 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A PDE4B P14646 Rattus norvegicus (Rat) 6.87316068078646 5.33674479166667 8 47 0 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) Pde4b TIAM1 Q13009 Homo sapiens (Human) 5 4.9125 1 2 0 T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1) TIAM1 GYRB P0C559 Mycobacterium smegmatis 6.48105194848638 5.35395833333333 25 27 0 DNA gyrase subunit B (EC 5.99.1.3) gyrB TYRO P11344 Mus musculus (Mouse) 4.06391180311205 5.03232142857143 7 9 0 Tyrosinase (EC 1.14.18.1) (Albino locus protein) (Monophenol monooxygenase) Tyr HMDH P04035 Homo sapiens (Human) 2.50318681318681 5.27966870882695 91 174 27.4725274725275 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) HMGCR HDAC4 P56524 Homo sapiens (Human) 5.45280282280576 5.28593267550364 269 3146 0.371747211895911 Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 KIAA0288 POLI Q9UNA4 Homo sapiens (Human) 4.21879290336118 5.31434134037798 16529 16770 17.8474196866114 DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B) POLI RAD30B HKDC1 Q2TB90 Homo sapiens (Human) 4.16653517334217 5.4649399759904 49 81 18.3673469387755 Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1) HKDC1 FUCO P04066 Homo sapiens (Human) 5.47876374963029 5.40388888888889 9 17 0 Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) FUCA1 Nbla10230 MRCKG Q6DT37 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) CDC42BPG DMPK2 PGKC P07378 Trypanosoma brucei brucei 4.69844746972468 5.4210037472077 443 447 46.0496613995485 Phosphoglycerate kinase, glycosomal (Phosphoglycerate kinase C) (EC 2.7.2.3) CFAD P00746 Homo sapiens (Human) 7.08576086956522 5.24982608695652 92 92 0 Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D) CFD DF PFD PAPA1 P00784 Carica papaya (Papaya) 5.25719814547283 5.21272443403591 61 63 8.19672131147541 Papain (EC 3.4.22.2) (Papaya proteinase I) (PPI) (allergen Car p 1) AMYP P00690 Sus scrofa (Pig) 3.623056054094 5.05625 2 2 0 Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) AMY2 TYSY P00469 Lactobacillus casei 4.23914300160926 5.09802083333333 4 4 0 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) thyA PNPH P55859 Bos taurus (Bovine) 6.80894543704722 5.0603125 4 11 0 Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP DUT P33316 Homo sapiens (Human) 5.21139201499649 5.31409653359349 25 29 0 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) DUT PKNG P9WI73 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.8424708072761 5.535 5 10 0 Serine/threonine-protein kinase PknG (EC 2.7.11.1) pknG Rv0410c MTCY22G10.06c Q4Q090 Q4Q090 Leishmania major 4.82107683551169 5.20329861111111 12 12 50 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC 5.4.2.1) PGAM LMJF_36_6650 HNMT P50135 Homo sapiens (Human) 5 4.9625 1 1 0 Histamine N-methyltransferase (HMT) (EC 2.1.1.8) HNMT Q81R22 Q81R22 Bacillus anthracis 5.79294434040782 5.03895833333333 4 6 0 Dihydrofolate reductase (EC 1.5.1.3) dfrA GBAA_2237 PSB11 A5LHX3 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-11 (EC 3.4.25.1) (Proteasome subunit beta-5t) PSMB11 DOPO P09172 Homo sapiens (Human) 3.95044977769132 5.29875 5 5 0 Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH LOX12 P39655 Mus musculus (Mouse) 4.52 5.90625 2 2 0 Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Lipoxin synthase 12-LO) (EC 3.3.2.-) (Platelet-type lipoxygenase 12) (P-12LO) Alox12 Alox12p TOP1 Q04750 Mus musculus (Mouse) 3.99139982823808 5.325 1 1 0 DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) Top1 Top-1 GRM5 Q3UVX5 Mus musculus (Mouse) 4.38501115055845 5.24940476190476 14 14 42.8571428571429 Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5 DOPO P15101 Bos taurus (Bovine) 4.77848457313308 5.37810307017544 38 38 0 Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH PA P03433 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 3.83483815336491 5.13338141025641 26 45 11.5384615384615 Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2) PA RDRP P03431 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 3.89903497642332 5.095 5 10 20 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1) PB1 MTOR P42345 Homo sapiens (Human) 6.23513532744459 5.33063293435872 614 948 11.5635179153094 Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 INMT O95050 Homo sapiens (Human) 4.16834113226132 5.0575 3 3 0 Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT) INMT UMPS P11172 Homo sapiens (Human) 4.07252577305926 5.3 3 3 0 Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)] UMPS OK/SW-cl.21 AA1R P28190 Bos taurus (Bovine) 6.4627835021373 5.27356812169312 63 66 0 Adenosine receptor A1 ADORA1 G3P P46406 Oryctolagus cuniculus (Rabbit) 2 5.2 1 1 0 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) GAPDH GAPD TRPC6 Q61143 Mus musculus (Mouse) 5.11013827874181 4.9875 1 1 0 Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6) Trpc6 Trp6 Trrp6 CENPE Q02224 Homo sapiens (Human) 2 5.1285 5 5 0 Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE) CENPE CD2 P06729 Homo sapiens (Human) 4.63202321470541 4.95 1 1 0 T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) CD2 SRBC UPAR P49616 Rattus norvegicus (Rat) 6.97333333333333 5.44166666666667 3 4 0 Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD antigen CD87) Plaur DDIT3 P35639 Mus musculus (Mouse) 4.63206693708152 5.36469160412758 82 83 36.5853658536585 DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153) Ddit3 Chop Chop10 Gadd153 SBK3 P0C264 Homo sapiens (Human) 5.16 5.46375 6 7 0 Uncharacterized serine/threonine-protein kinase SBK3 (EC 2.7.11.1) (SH3-binding domain kinase family member 3) (Sugen kinase 110) SBK3 SGK110 VDR Q28037 Bos taurus (Bovine) 4.36969933069581 5.83125 2 2 0 Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) VDR NR1I1 S12A5 Q63633 Rattus norvegicus (Rat) 5.07333333333333 5.05416666666667 3 3 0 Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Furosemide-sensitive K-Cl cotransporter) (K-Cl cotransporter 2) (rKCC2) (Neuronal K-Cl cotransporter) Slc12a5 Kcc2 KDM4A O75164 Homo sapiens (Human) 4.48976406680624 5.31018232749038 6616 19947 24.0477629987908 Lysine-specific demethylase 4A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) KDM4A JHDM3A JMJD2 JMJD2A KIAA0677 ATS4 O75173 Homo sapiens (Human) 5.07693140339237 5.28961538461538 13 14 0 A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) ADAMTS4 KIAA0688 UNQ769/PRO1563 5HT3E A5X5Y0 Homo sapiens (Human) 6.91008769117749 5.35854288339837 50 294 0 5-hydroxytryptamine receptor 3E (5-HT3-E) (5-HT3E) (Serotonin receptor 3E) HTR3E SCD5 Q86SK9 Homo sapiens (Human) 5.25717600346882 5.3825 5 5 0 Stearoyl-CoA desaturase 5 (EC 1.14.19.1) (Acyl-CoA-desaturase 4) (HSCD5) (Stearoyl-CoA 9-desaturase) (Stearoyl-CoA desaturase 2) SCD5 ACOD4 SCD2 SCD4 MGA O43451 Homo sapiens (Human) 4.6271012522199 5.22348039215686 17 19 5.88235294117647 Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)] MGAM MGA MGAML PNPH P00491 Homo sapiens (Human) 6.87551787053438 5.35871011251129 42 58 0 Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP B0BL08 B0BL08 Escherichia coli 6.64001433503553 5.32642515432099 54 64 0 Dihydrofolate reductase dfrA17 5HT3C Q8WXA8 Homo sapiens (Human) 6.91008769117749 5.35854288339837 50 294 0 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C) HTR3C DNM3A Q9Y6K1 Homo sapiens (Human) 4.37361969406034 5.20041666666667 6 12 0 DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) DNMT3A MBTD1 Q05BQ5 Homo sapiens (Human) 3.90754239930823 5.182875 10 13 0 MBT domain-containing protein 1 MBTD1 PGH1 O62664 Bos taurus (Bovine) 5.16824122257046 5.41356826241135 47 83 0 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX-1 COX1 KCMA1 Q62976 Rattus norvegicus (Rat) 4.38826381108641 5.02166666666667 6 8 0 Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) Kcnma1 Kcnma GRP1 O95267 Homo sapiens (Human) 5 7.8 1 1 0 RAS guanyl-releasing protein 1 (Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein) RASGRP1 RASGRP PLK1 P53350 Homo sapiens (Human) 4.6983164584754 5.29036873564803 3725 3799 21.5570469798658 Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13) PLK1 PLK PARP3 Q9Y6F1 Homo sapiens (Human) 4.68833333333333 5.23135416666667 6 6 0 Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 CRTM A9JQL9 Staphylococcus aureus 5.72455408077824 5.32649448842183 11 13 0 Dehydrosqualene synthase (EC 2.5.1.96) (4,4'-diapophytoene synthase) (DAP synthase) (Diapophytoene synthase) crtM ATX2 Q99700 Homo sapiens (Human) 5.26335027227865 5.30568304572568 5840 5875 23.2705479452055 Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) ATXN2 ATX2 SCA2 TNRC13 AK1CL Q91WR5 Mus musculus (Mouse) 4.7501225267834 4.93333333333333 1 1 100 Aldo-keto reductase family 1 member C21 (EC 1.1.1.-) (17-alpha-hydroxysteroid dehydrogenase) (17-alpha-HSD) (3(or 17)-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.209) (3-alpha-hydroxysteroid dehydrogenase) (Dihydrodiol dehydrogenase type 1) (DD1) (Dihydrodiol dehydrogenase type 3) (DD3) Akr1c21 DYN1 Q05193 Homo sapiens (Human) 3.61731681685976 5.21916666666666 11 22 0 Dynamin-1 (EC 3.6.5.5) DNM1 DNM TRXR1 Q16881 Homo sapiens (Human) 4.73571428571429 5.28839285714286 7 17 0 Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1) TXNRD1 GRIM12 KDRF P53 P02340 Mus musculus (Mouse) 5 4.8425 1 1 0 Cellular tumor antigen p53 (Tumor suppressor p53) Tp53 P53 Trp53 TRXR2 Q9NNW7 Homo sapiens (Human) 4.44 5.33375 5 15 0 Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3) TXNRD2 KIAA1652 TRXR2 MZB1 Q9D8I1 Mus musculus (Mouse) 5 5.375 1 1 0 Marginal zone B- and B1-cell-specific protein (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) Mzb1 Pacap PGFRA P26618 Mus musculus (Mouse) 4.94201065919805 5.46375994140534 28 60 3.57142857142857 Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a) Pdgfra TBB8 Q3ZCM7 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin beta-8 chain (Tubulin beta 8 class VIII) TUBB8 POLG P26663 Hepatitis C virus genotype 1b (isolate BK) (HCV) 6.96125 5.38125 8 8 12.5 Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)] Q9GPQ4 Q9GPQ4 Trypanosoma vivax (Duttonella vivax) 3.23026138086329 5.43333333333333 3 3 0 IAG-nucleoside hydrolase GBRR3 A8MPY1 Homo sapiens (Human) 4.45593195564972 5.3625 1 3 0 Gamma-aminobutyric acid receptor subunit rho-3 (GABA(A) receptor subunit rho-3) (GABA(C) receptor) GABRR3 VM1B1 P83512 Bothrops asper (Terciopelo) 5.63 5.12499999999999 2 2 0 Snake venom metalloproteinase BaP1 (SVMP) (EC 3.4.24.-) (Hemorrhagic metalloproteinase BaP1) (Bap-1) PSB5 P28074 Homo sapiens (Human) 5.90515095880949 5.70388157894737 26 72 0 Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) PSMB5 LMPX MB1 X FABH P9WNG3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 3.23424595160841 5.15793981481481 9 12 0 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthase III) (Beta-ketoacyl-ACP synthase III) (KAS III) (MtFabH) fabH Rv0533c MTCY25D10.12c ADA2B P18089 Homo sapiens (Human) 3.71360318454823 5.23879851746707 129 277 20.9302325581395 Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) ADRA2B ADRA2L1 ADRA2RL1 PHOQ P0DM80 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 5 4.95 4 4 0 Virulence sensor histidine kinase PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ) phoQ phoZ STM1230 UBP2 O75604 Homo sapiens (Human) 2.99793192091317 5.38113624028734 942 1022 32.9087048832272 Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 AKT1 P31749 Homo sapiens (Human) 4.94799729137222 5.26412335296159 486 610 2.05761316872428 RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) AKT1 PKB RAC VDR A3RGC1 Sus scrofa (Pig) 6.42731206660625 5.1859375 8 8 0 Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) VDR NR1I1 CBPB2 Q96IY4 Homo sapiens (Human) 6.38223365692776 5.38987049549549 37 45 0 Carboxypeptidase B2 (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Plasma carboxypeptidase B) (pCPB) (Thrombin-activable fibrinolysis inhibitor) (TAFI) CPB2 ERN1 O75460 Homo sapiens (Human) 6.16743816157153 5.22526829346708 81 83 0 Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 EPHB4 P54760 Homo sapiens (Human) 5.06177105143327 5.22386893656716 134 182 5.97014925373134 Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) EPHB4 HTK MYK1 TYRO11 CLK3 P49761 Homo sapiens (Human) 4.58210656347118 5.20043535268338 75 129 13.3333333333333 Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3) CLK3 NADD C3L5T6 Bacillus anthracis (strain CDC 684 / NRRL 3495) 4.5475 4.875 2 3 50 Probable nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) nadD BAMEG_4595 P53 P04637 Homo sapiens (Human) 4.63583587793169 5.23023584294668 7760 10680 52.7061855670103 Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) TP53 P53 DPO3B P0A988 Escherichia coli (strain K12) 4.17210445163964 5.293707083514 6 19 0 Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) dnaN b3701 JW3678 IGF1R P08069 Homo sapiens (Human) 4.64234580669649 5.26807353737611 389 497 3.08483290488432 Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] IGF1R PDK4 Q16654 Homo sapiens (Human) 5.00739078068969 5.57650462962963 27 108 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) PDK4 PDHK4 LKHA4 P09960 Homo sapiens (Human) 5.7469394364758 5.21973484848485 44 72 2.27272727272727 Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H LTA4 PTN12 Q05209 Homo sapiens (Human) 4.68428571428571 5.37526785714286 7 7 0 Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) PTPN12 ITAL P20701 Homo sapiens (Human) 5.50142288002321 5.38811868686869 33 143 0 Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) ITGAL CD11A BRAF P15056 Homo sapiens (Human) 5.94810581839029 5.2662940752898 155 278 2.58064516129032 Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 ECR P49880 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 6.15 4.85 1 1 0 Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (AaEcR) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 AAEL009600 SCNAA Q9Y5Y9 Homo sapiens (Human) 5.05966565729184 5.29173897684367 11 22 0 Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) SCN10A RIPK3 Q9Y572 Homo sapiens (Human) 2 4.9 1 1 100 Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) RIPK3 RIP3 EED O75530 Homo sapiens (Human) 5.32 4.92708333333333 1 3 0 Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) EED OX1R O43613 Homo sapiens (Human) 5.92901073558565 5.15448991935484 155 201 9.67741935483871 Orexin receptor type 1 (Ox-1-R) (Ox1-R) (Ox1R) (Hypocretin receptor type 1) HCRTR1 PNPH P85973 Rattus norvegicus (Rat) 5.54697634932738 5.32786458333334 2 3 0 Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) Pnp Np NISCH Q4G017 Rattus norvegicus (Rat) 5.15495397977211 5.17984126984127 21 24 0 Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline-1 receptor) (I1R) Nisch PA24A A4IFJ5 Bos taurus (Bovine) 5.33 5.13571428571428 7 7 0 Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 PCSK7 Q16549 Homo sapiens (Human) 6.50833333333333 4.95 6 6 0 Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7) PCSK7 LPC PC7 PC8 SPC7 CPXA P00183 Pseudomonas putida (Arthrobacter siderocapsulatus) 4.65550580367635 4.95625 2 3 0 Camphor 5-monooxygenase (EC 1.14.15.1) (Cytochrome P450-cam) (Cytochrome P450cam) camC cyp101 G6PC P35575 Homo sapiens (Human) 3.62548519451997 5.37475 5 5 0 Glucose-6-phosphatase (G-6-Pase) (G6Pase) (EC 3.1.3.9) (Glucose-6-phosphatase alpha) (G6Pase-alpha) G6PC G6PT GBRA4 P48169 Homo sapiens (Human) 5.66780643647425 5.2543603286385 71 1162 1.40845070422535 Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) GABRA4 OX2R O43614 Homo sapiens (Human) 5.85449827941035 5.14887310606061 199 249 8.5427135678392 Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 PTPRM P28827 Homo sapiens (Human) 4.05102999566398 5.765625 4 4 0 Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 SSR4 P31391 Homo sapiens (Human) 6.42517475510044 5.00265706806284 191 223 0 Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) SSTR4 NRP1 O14786 Homo sapiens (Human) 4.54688611746134 5.37491666666666 10 20 0 Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) NRP1 NRP VEGF165R MRP4 O15439 Homo sapiens (Human) 4.59591577858137 5.61805555555556 6 9 50 Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 3MG P29372 Homo sapiens (Human) 6.7 4.8375 1 1 0 DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) MPG AAG ANPG MID1 KDM6A O15550 Homo sapiens (Human) 4 6.425 1 1 0 Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) KDM6A UTX PI51A Q99755 Homo sapiens (Human) 5.31926035557268 5.38833333333333 11 13 9.09090909090909 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) PIP5K1A PANC P9WIL5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.27347499285356 5.4552536231884 23 25 0 Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme) panC Rv3602c MTCY07H7B.20 AA2AR P29274 Homo sapiens (Human) 5.44023947308298 5.24436300602933 715 972 4.47552447552448 Adenosine receptor A2a ADORA2A ADORA2 CCNB3 Q8WWL7 Homo sapiens (Human) 5.54324272491158 5.14633839831804 109 620 9.1743119266055 G2/mitotic-specific cyclin-B3 CCNB3 CYCB3 GRIK4 Q16099 Homo sapiens (Human) 4.14138837853326 5.23486111111111 3 25 0 Glutamate receptor ionotropic, kainate 4 (GluK4) (Excitatory amino acid receptor 1) (EAA1) (Glutamate receptor KA-1) (KA1) GRIK4 GRIK GRIK5 Q16478 Homo sapiens (Human) 6.03610680089096 5.52379901960784 17 41 0 Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2) GRIK5 GRIK2 GBRG1 Q8N1C3 Homo sapiens (Human) 6.06563810270715 5.23357096354167 64 1147 1.5625 Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) GABRG1 ITPR3 Q14573 Homo sapiens (Human) 5.01357142857143 5.0375 2 13 0 Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) ITPR3 KCNN2 Q9H2S1 Homo sapiens (Human) 6.275 5.420625 2 3 0 Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) KCNN2 S15A2 Q16348 Homo sapiens (Human) 4.899 5.3378125 10 19 0 Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2) SLC15A2 PEPT2 TMPS6 Q8IU80 Homo sapiens (Human) 4.74694503740609 5.14127155172414 29 29 0 Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) TMPRSS6 UNQ354/PRO618 S6A13 Q9NSD5 Homo sapiens (Human) 6.69019608002851 4.9375 1 1 0 Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) SLC6A13 GAT2 P2RX5 Q93086 Homo sapiens (Human) 2 5.64 1 1 0 P2X purinoceptor 5 (P2X5) (ATP receptor) (Purinergic receptor) P2RX5 P2X5 PP1A P62136 Homo sapiens (Human) 4.04195131637813 5.59483333333333 15 15 26.6666666666667 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) PPP1CA PPP1A NMD3A Q8TCU5 Homo sapiens (Human) 5.63643181719356 5.21372532894737 38 365 0 Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) GRIN3A KIAA1973 INCE Q9NQS7 Homo sapiens (Human) 7.7125 4.9125 2 6 0 Inner centromere protein INCENP GRIK3 Q13003 Homo sapiens (Human) 4.98402752259996 5.28618055555555 6 29 0 Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7) GRIK3 GLUR7 DPP2 Q9UHL4 Homo sapiens (Human) 4.73569236925293 5.30885903823027 159 171 0 Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) DPP7 DPP2 QPP KC1AL Q8N752 Homo sapiens (Human) 4.70689640617649 5.255625 8 10 12.5 Casein kinase I isoform alpha-like (CKI-alpha-like) (EC 2.7.11.1) (CK1) CSNK1A1L NMBR P28336 Homo sapiens (Human) 5.63333333333333 5.28159722222222 18 18 0 Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor) NMBR MP2K1 Q02750 Homo sapiens (Human) 4.9066287870523 5.24598886818765 245 345 4.48979591836735 Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) MAP2K1 MEK1 PRKMK1 PPIB P23284 Homo sapiens (Human) 7.22730769230769 5.06110576923077 13 14 0 Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB RPA1 O95602 Homo sapiens (Human) 4.38 5.0975 1 1 0 DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) POLR1A SCN5A Q14524 Homo sapiens (Human) 5.07786059151537 5.17117121525332 60 73 0 Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) SCN5A SENP1 Q9P0U3 Homo sapiens (Human) 4.53585801077671 5.20406168299988 30 52 20 Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1) SENP1 ABCC9 O60706 Homo sapiens (Human) 5.92668922506663 5.28938703703704 30 178 0 ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2) ABCC9 SUR2 BGAL P16278 Homo sapiens (Human) 3.50022606832323 5.084375 4 4 0 Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) GLB1 ELNR1 AOXA Q06278 Homo sapiens (Human) 6.16722687557547 5.19375 2 2 50 Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-) AOX1 AO NPBW1 P48145 Homo sapiens (Human) 4.32607084203846 5.16683333333333 15 15 6.66666666666667 Neuropeptides B/W receptor type 1 (G-protein coupled receptor 7) NPBWR1 GPR7 NPY5R Q15761 Homo sapiens (Human) 6.63839618443976 5.11432680348259 134 144 1.49253731343284 Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) NPY5R NPYR5 GATA4 P43694 Homo sapiens (Human) 4.96908198225437 6.084375 1 3 0 Transcription factor GATA-4 (GATA-binding factor 4) GATA4 NPY5R Q63634 Rattus norvegicus (Rat) 7.62194313010701 5.41388888888889 3 4 0 Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) Npy5r Npyr5 MDHM P40926 Homo sapiens (Human) 5.46681148312568 5 4 4 25 Malate dehydrogenase, mitochondrial (EC 1.1.1.37) MDH2 KDM5A P29375 Homo sapiens (Human) 4.3818108876707 5.77375 4 8 0 Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) KDM5A JARID1A RBBP2 RBP2 MAST4 O15021 Homo sapiens (Human) 5.59665152190411 4.9625 1 1 0 Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1) MAST4 KIAA0303 KCNA3 P22001 Homo sapiens (Human) 6.84874835124408 5.00782608695652 23 35 0 Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 LYAM3 P16109 Homo sapiens (Human) 4.71805015106652 5.56833333333333 14 14 7.14285714285714 P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) SELP GMRP GRMP KCNA3 P16390 Mus musculus (Mouse) 4.60124087830816 5.356640625 8 11 0 Potassium voltage-gated channel subfamily A member 3 (MK3) (Voltage-gated potassium channel subunit Kv1.3) Kcna3 BCAT1 P54687 Homo sapiens (Human) 4.41054388837488 4.901 5 5 0 Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39) BCAT1 BCT1 ECA39 PIM3 Q86V86 Homo sapiens (Human) 5.39101715094517 5.23487380674881 286 372 4.1958041958042 Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) PIM3 PDE6A P16499 Homo sapiens (Human) 5.97538419506865 5.32126785714286 35 160 0 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1) PDE6A PDEA PLCG2 P16885 Homo sapiens (Human) 3.425 5.37291666666667 6 9 33.3333333333333 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) PLCG2 TLR5 O60602 Homo sapiens (Human) 3.30434782608696 5.11851449275362 23 25 0 Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) TLR5 TIL3 MTAP2 P11137 Homo sapiens (Human) 4.66444110982587 5.67477928664344 7 10 0 Microtubule-associated protein 2 (MAP-2) MAP2 GLI2 P10070 Homo sapiens (Human) 6.04 4.975 1 1 0 Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) GLI2 THP C11B1 P15538 Homo sapiens (Human) 6.12487009044313 5.25814010779617 164 198 0 Cytochrome P450 11B1, mitochondrial (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4) CYP11B1 S11BH ARGI1 P05089 Homo sapiens (Human) 3.78123468415208 5.4375 2 3 0 Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase) ARG1 KSYK P43405 Homo sapiens (Human) 5.76704479207845 5.31723759305211 403 486 1.98511166253102 Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk) SYK NR2E3 Q9Y5X4 Homo sapiens (Human) 5.13868880847179 5.19682556497175 59 60 23.728813559322 Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) NR2E3 PNR RNR MURI Q9ZLT0 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) 6.34 5.0249678126355 8 8 0 Glutamate racemase (EC 5.1.1.3) murI glr jhp_0496 ULK2 Q8IYT8 Homo sapiens (Human) 5.82365019092285 5.09936848958333 32 42 25 Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) ULK2 KIAA0623 SO2A1 Q92959 Homo sapiens (Human) 2 4.8375 1 1 0 Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) SLCO2A1 OATP2A1 SLC21A2 C1R P00736 Homo sapiens (Human) 4.47801146507931 5.27241319444444 12 21 8.33333333333333 Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain] C1R CP26A O43174 Homo sapiens (Human) 6.20450082723656 5.38625 16 25 0 Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) CYP26A1 CYP26 P450RAI1 GRIA4 P48058 Homo sapiens (Human) 5.65192483446397 5.3297762345679 27 59 0 Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) GRIA4 GLUR4 RECQ1 P46063 Homo sapiens (Human) 5.00878190411613 5.3207003379532 671 821 29.9552906110283 ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1) RECQL RECQ1 RECQL1 M3K1 Q13233 Homo sapiens (Human) 5.46905913450423 5.49840909090909 11 12 0 Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) MAP3K1 MAPKKK1 MEKK MEKK1 ITB1 P05556 Homo sapiens (Human) 6.84963243579489 5.25045164242639 103 284 0 Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 FNRB MDF2 MSK12 MK08 P45983 Homo sapiens (Human) 4.83482226252013 5.28900493020155 399 514 2.25563909774436 Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) MAPK8 JNK1 PRKM8 SAPK1 SAPK1C NLRP3 Q96P20 Homo sapiens (Human) 5.19285714285714 5.06745535714286 14 28 21.4285714285714 NACHT, LRR and PYD domains-containing protein 3 (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1) NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 FLT3 P36888 Homo sapiens (Human) 4.98368843882011 5.26499798269281 407 611 3.43980343980344 Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) FLT3 CD135 FLK2 STK1 E2QDN0 E2QDN0 Escherichia coli 6.09 5.0125 1 1 0 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) thyA APU18_04985 BK383_19980 KDM4E B2RXH2 Homo sapiens (Human) 4.55511956671798 5.31935739626106 6952 7065 33.1703107019563 Lysine-specific demethylase 4E (EC 1.14.11.-) (KDM4D-like protein) (Lysine-specific demethylase 4D-like) KDM4E KDM4DL Q9NAW4 Q9NAW4 Plasmodium falciparum 4.7817977748871 5.2475 9 9 0 Cysteine protease falcipain-3 DEF P9WIJ3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 6.1 5.5725 1 1 0 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) def Rv0429c MTCY22G10.26c POLG P06935 West Nile virus (WNV) 4.28645731262503 5.21501736111111 12 12 0 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (NS5)] T23O P48776 Mus musculus (Mouse) 3.56346310628912 5.11000718390805 29 29 3.44827586206897 Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) Tdo2 Tdo EPHA1 P21709 Homo sapiens (Human) 5.55893905900106 5.15932291666667 40 70 22.5 Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) EPHA1 EPH EPHT EPHT1 GCKR Q14397 Homo sapiens (Human) 5.28696956707691 5.23305555555555 6 6 0 Glucokinase regulatory protein (GKRP) (Glucokinase regulator) GCKR MDM4 O15151 Homo sapiens (Human) 6.42051612903226 4.99045698924731 31 36 0 Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX JAK1 P23458 Homo sapiens (Human) 6.9489707868587 5.30143538232169 279 708 0.3584229390681 Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) JAK1 JAK1A JAK1B GRM1 Q13255 Homo sapiens (Human) 4.39102261161386 5.3695132619021 141 194 1.41843971631206 Metabotropic glutamate receptor 1 (mGluR1) GRM1 GPRC1A MGLUR1 KCNA1 Q09470 Homo sapiens (Human) 5.47483442802019 5.28958333333333 6 6 0 Potassium voltage-gated channel subfamily A member 1 (Voltage-gated K(+) channel HuKI) (Voltage-gated potassium channel HBK1) (Voltage-gated potassium channel subunit Kv1.1) KCNA1 BLO1 P13661 Escherichia coli 6.685 5.0875 1 2 0 Beta-lactamase OXA-1 (EC 3.5.2.6) (Penicillinase) bla oxa1 EP300 Q09472 Homo sapiens (Human) 4.69122421219524 5.17244761904762 25 62 4 Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) EP300 P300 CNR2 Q9QZN9 Rattus norvegicus (Rat) 4.74347718523608 5.1865625 4 6 0 Cannabinoid receptor 2 (CB-2) (CB2) (rCB2) Cnr2 B9W6M3 B9W6M3 Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) (Yeast) 3.80092291788184 5.23791666666667 36 37 30.5555555555556 Serine/threonine-protein phosphatase (EC 3.1.3.16) CNA1 Cd36_00650 CD36_00650 CSF1R P07333 Homo sapiens (Human) 4.76891559482082 5.31159061809028 332 398 3.6144578313253 Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) CSF1R FMS EHMT1 Q9H9B1 Homo sapiens (Human) 5.44650437777208 5.06493055555555 6 14 0 Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D PLIN1 O60240 Homo sapiens (Human) 5.51388850742994 5.36011111111111 15 15 40 Perilipin-1 (Lipid droplet-associated protein) PLIN1 PERI PLIN ENTK P98073 Homo sapiens (Human) 6.01145793314112 5.40036458333333 48 48 29.1666666666667 Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 PLAP Q9Y263 Homo sapiens (Human) 4.19333333333333 5.35 6 6 16.6666666666667 Phospholipase A-2-activating protein (PLA2P) (PLAP) PLAA PLAP TBA3E Q6PEY2 Homo sapiens (Human) 5.04431018854817 5.18361564009662 69 1485 0 Tubulin alpha-3E chain (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] TUBA3E TR10B O14763 Homo sapiens (Human) 5 5.05 1 1 100 Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186 PAFA2 Q8VDG7 Mus musculus (Mouse) 5 5.375 1 1 0 Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (Serine-dependent phospholipase A2) (SD-PLA2) Pafah2 DNK Q9XZT6 Drosophila melanogaster (Fruit fly) 4.47666666666667 5.27645833333333 3 4 0 Deoxynucleoside kinase (EC 2.7.1.145) (Deoxyribonucleoside kinase) (Dm-dNK) (Multispecific deoxynucleoside kinase) dnk CG5452 FAK2 Q14289 Homo sapiens (Human) 3.86247207915475 5.24709528688525 183 224 17.4863387978142 Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK) PTK2B FAK2 PYK2 RAFTK C1KUY3 C1KUY3 Acyrthosiphon pisum (Pea aphid) 5 5.2375 1 1 0 Odorant-binding protein 3 (Fragment) obp3 CAC1F O60840 Homo sapiens (Human) 7.31290402075269 5.32762120786137 10 48 0 Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage-gated calcium channel subunit alpha Cav1.4) CACNA1F CACNAF1 CALRL Q16602 Homo sapiens (Human) 7.40328080903848 5.37169559528033 77 151 0 Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) CALCRL CGRPR PDE6B P35913 Homo sapiens (Human) 5.3707378730961 5.464775 25 150 0 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35) PDE6B PDEB ITA2B P08514 Homo sapiens (Human) 6.70032192072388 5.37405609492988 206 516 0 Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2] ITGA2B GP2B ITGAB PTPRF P10586 Homo sapiens (Human) 3.69839815255708 5.30357206825038 26 58 0 Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) PTPRF LAR NCOR2 Q9Y618 Homo sapiens (Human) 5.443108653614 5.27419117647059 51 106 23.5294117647059 Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) NCOR2 CTG26 NR1H4 Q96RI1 Homo sapiens (Human) 4.6143002870276 5.34277549764148 108 164 18.5185185185185 Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) NR1H4 BAR FXR HRR1 RIP14 PTN2 P17706 Homo sapiens (Human) 4.98221990060127 5.29068055555556 45 49 0 Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) PTPN2 PTPT NEUR2 Q9Y3R4 Homo sapiens (Human) 3.81108855666754 5.11041666666667 8 8 37.5 Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2) NEU2 NMDE4 O15399 Homo sapiens (Human) 5.64373444877251 5.21261513157895 38 364 0 Glutamate receptor ionotropic, NMDA 2D (GluN2D) (EB11) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D) GRIN2D GluN2D NMDAR2D NEK4 P51957 Homo sapiens (Human) 2.92790835009085 5.24183289007092 94 94 0 Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 HCN1 O60741 Homo sapiens (Human) 4 5.10833333333333 1 1 0 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) HCN1 BCNG1 ADA12 O43184 Homo sapiens (Human) 3.79 5.38395833333333 3 3 0 Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) ADAM12 MLTN UNQ346/PRO545 TA2R P21731 Homo sapiens (Human) 5.60468811067349 5.37494220182713 58 85 0 Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor) TBXA2R CDKL1 Q00532 Homo sapiens (Human) 5 5.37208333333333 6 6 0 Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Protein kinase p42 KKIALRE) (Serine/threonine-protein kinase KKIALRE) CDKL1 GPR88 Q9GZN0 Homo sapiens (Human) 6.17143937264017 5.10625 2 2 0 Probable G-protein coupled receptor 88 (Striatum-specific G-protein coupled receptor) GPR88 STRG FAAH1 P97612 Rattus norvegicus (Rat) 6.13099250176426 5.22557463566349 141 179 0 Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1) Faah Faah1 GRIK1 P39086 Homo sapiens (Human) 5.72676090451021 5.35790064102564 52 79 0 Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5) GRIK1 GLUR5 CLC4K Q9UJ71 Homo sapiens (Human) 5.95424250943933 5.4625 1 1 0 C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) CD207 CLEC4K IDE P14735 Homo sapiens (Human) 4.26349913401496 5.15891931114026 38 61 21.0526315789474 Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) IDE KCNH2 Q12809 Homo sapiens (Human) 4.66160850373904 5.29182659660108 815 1027 6.99386503067485 Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 ERG ERG1 HERG ERR2 O95718 Homo sapiens (Human) 5.87333333333333 5.15833333333333 5 7 20 Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) ESRRB ERRB2 ESRL2 NR3B2 ACOT2 Q9QYR9 Mus musculus (Mouse) 5 5.375 1 1 0 Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase) Acot2 Mte1 BRD9 Q9H8M2 Homo sapiens (Human) 5.34 5.139 5 5 0 Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS-40.8) BRD9 UNQ3040/PRO9856 MRAY Q03521 Bacillus subtilis (strain 168) 3.44369749923271 4.94375 1 1 0 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) mraY BSU15190 TRYD Q9BZJ3 Homo sapiens (Human) 7.58950799129486 5.57701388888889 27 93 0 Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3) TPSD1 PA2GX O15496 Homo sapiens (Human) 5.35091977339769 5.21039351851852 9 10 0 Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10) PLA2G10 MDR1A P21447 Mus musculus (Mouse) 4.25108762293923 5.47083333333333 6 7 0 Multidrug resistance protein 1A (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1A) (MDR1A) (Multidrug resistance protein 3) (P-glycoprotein 3) Abcb1a Abcb4 Mdr1a Mdr3 Pgy-3 Pgy3 FTSZ P17865 Bacillus subtilis (strain 168) 4.13830269816628 5.4625 1 1 0 Cell division protein FtsZ ftsZ BSU15290 TY3H P07101 Homo sapiens (Human) 4.04575749056067 6.67422750325202 1 1 0 Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) TH TYH ASAH1 Q13510 Homo sapiens (Human) 4.67091210946541 5.63940656210669 6 15 0 Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) (Putative 32 kDa heart protein) (PHP32) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] ASAH1 ASAH HSD-33 HSD33 LTC4S A6XA80 Cavia porcellus (Guinea pig) 2.0425 5.27248420201117 84 167 30.952380952381 Leukotriene C4 synthase (LTC4 synthase) (EC 4.4.1.20) (Leukotriene-C(4) synthase) LTC4S RNS P00669 Bos taurus (Bovine) 4.38 5.375 3 3 0 Seminal ribonuclease (S-RNase) (Seminal RNase) (EC 3.1.27.5) (Ribonuclease BS-1) SRN PPARD Q03181 Homo sapiens (Human) 4.53987158127168 5.29909845871014 211 350 13.2701421800948 Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) PPARD NR1C2 PPARB KLK14 Q9P0G3 Homo sapiens (Human) 5.25205457470258 5.01651785714286 7 10 14.2857142857143 Kallikrein-14 (hK14) (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6) KLK14 KLKL6 AOC1 P19801 Homo sapiens (Human) 4.78666666666667 5.2125 3 3 0 Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) AOC1 ABP1 DAO1 GNAQ P50148 Homo sapiens (Human) 4.04575749056067 5 1 1 100 Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q) GNAQ GAQ ATS5 Q9UNA0 Homo sapiens (Human) 5.55319264803818 5.42116935483871 31 33 0 A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2) ADAMTS5 ADAMTS11 ADMP2 REV P05866 Human immunodeficiency virus type 1 group M subtype B (isolate WMJ22) (HIV-1) 4.96344787323145 5.76 3 3 0 Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression of viral proteins) (Fragment) rev PGAP1 Q3UUQ7 Mus musculus (Mouse) 5 5.375 1 1 0 GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) Pgap1 FRIL P02791 Equus caballus (Horse) 3.77873627970859 5.30169607246179 5102 5262 26.5974127793022 Ferritin light chain (Ferritin L subunit) FTL DDHD2 Q80Y98 Mus musculus (Mouse) 5 5.375 1 1 0 Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (SAM, WWE and DDHD domain-containing protein 1) Ddhd2 Kiaa0725 Samwd1 ADH6 P28332 Homo sapiens (Human) 4.6259059864969 5.26 2 14 0 Alcohol dehydrogenase 6 (EC 1.1.1.1) ADH6 AUR1 O13332 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 4.93 5.25 1 1 0 Inositol phosphorylceramide synthase (IPC synthase) (EC 2.-.-.-) (Aureobasidin A resistance protein homolog) (Phosphatidylinositol:ceramide phosphoinositol transferase) AUR1 CAALFM_C501240WA CaO19.1945 CaO19.9500 WEE2 P0C1S8 Homo sapiens (Human) 5 5.38857142857143 7 8 0 Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase) WEE2 WEE1B THAS P24557 Homo sapiens (Human) 4.81371401150712 5.29813789098752 225 327 11.5555555555556 Thromboxane-A synthase (TXA synthase) (TXS) (EC 5.3.99.5) (Cytochrome P450 5A1) TBXAS1 CYP5 CYP5A1 CBX4 O00257 Homo sapiens (Human) 6.54 4.9375 1 1 0 E3 SUMO-protein ligase CBX4 (EC 6.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) CBX4 KITM O00142 Homo sapiens (Human) 5.08923093058963 5.22741071428571 7 8 0 Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK) TK2 AMPN P04825 Escherichia coli (strain K12) 4.51143937264017 5.559375 4 4 0 Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) pepN b0932 JW0915 PPCE P23687 Sus scrofa (Pig) 6.485 5.0625 2 2 0 Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP NALD2 Q9Y3Q0 Homo sapiens (Human) 6.47 5.25 1 1 0 N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 NSF P46459 Homo sapiens (Human) 2 5.5 1 1 0 Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) NSF GLO2 Q3B7M2 Bos taurus (Bovine) 6.975 4.95 2 2 0 Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) HAGH TGM3 Q08188 Homo sapiens (Human) 4.14794000867204 5.48666666666667 3 3 0 Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain] TGM3 BAZ2A Q9UIF9 Homo sapiens (Human) 5.875 5.28 2 4 0 Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3) BAZ2A KIAA0314 TIP5 SUCR1 Q9BXA5 Homo sapiens (Human) 2 5.05 1 1 0 Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like) SUCNR1 GPR91 ULK3 Q6PHR2 Homo sapiens (Human) 5.47949919766543 5.15705787037037 36 53 22.2222222222222 Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) ULK3 ITPR2 Q14571 Homo sapiens (Human) 4.9175 5.0375 2 12 0 Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) ITPR2 P2RX3 P56373 Homo sapiens (Human) 6.17649861814719 5.20088541666667 44 47 2.27272727272727 P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) P2RX3 PGTB1 P53609 Homo sapiens (Human) 5.76485712053572 5.39964717741935 62 133 0 Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) PGGT1B CAH4 P22748 Homo sapiens (Human) 5.86724431872522 5.25990301724138 58 171 6.89655172413793 Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) CA4 PIN1 Q13526 Homo sapiens (Human) 4.28046344223044 5.31164540226068 4215 4253 26.9276393831554 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) PIN1 STK35 Q8TDR2 Homo sapiens (Human) 5.44 5.38857142857143 7 8 0 Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1) STK35 CLIK1 PDIK1 STK35L1 FGF2 P09038 Homo sapiens (Human) 6.45562188015288 5.0094476744186 43 44 0 Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) FGF2 FGFB KKCC2 Q96RR4 Homo sapiens (Human) 5.50458587627766 5.25483455882353 34 40 11.7647058823529 Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta) CAMKK2 CAMKKB KIAA0787 ABCBB O95342 Homo sapiens (Human) 5.395 5.4 2 2 0 Bile salt export pump (ATP-binding cassette sub-family B member 11) ABCB11 BSEP M3K6 O95382 Homo sapiens (Human) 5.01428571428571 5.38857142857143 7 8 0 Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 2) MAP3K6 ASK2 MAPKKK6 MEKK6 CA2D1 P54289 Homo sapiens (Human) 6.8275 4.94125 4 4 0 Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] CACNA2D1 CACNL2A CCHL2A MHS3 DUS3 P51452 Homo sapiens (Human) 4.86082154909026 5.301721117158 80 94 16.25 Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) DUSP3 VHR KLK1 P06870 Homo sapiens (Human) 4.72378995643336 5.36397058823529 17 17 0 Kallikrein-1 (EC 3.4.21.35) (Kidney/pancreas/salivary gland kallikrein) (Tissue kallikrein) KLK1 SHIP2 O15357 Homo sapiens (Human) 4.03135252588338 5.090625 2 2 0 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) INPPL1 SHIP2 Q81VW8 Q81VW8 Bacillus anthracis 4.67774744832337 5.8925 3 5 0 Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) folP GBAA_0071 NR1H2 P55055 Homo sapiens (Human) 4.21291514639837 5.26938796041921 390 446 64.8717948717949 Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) NR1H2 LXRB NER UNR DHB1 P14061 Homo sapiens (Human) 4.63023973415262 5.185885286132 133 183 2.25563909774436 Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1) HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 SDR28C1 TNKS2 Q9H2K2 Homo sapiens (Human) 6.00287703782154 5.29547354497355 63 112 4.76190476190476 Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related protein) TNKS2 PARP5B TANK2 TNKL MYO3B Q8WXR4 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Myosin-IIIb (EC 2.7.11.1) MYO3B Q8IL11 Q8IL11 Plasmodium falciparum (isolate 3D7) 4.86577592794588 5.38300735294118 170 170 34.1176470588235 M17 leucyl aminopeptidase (EC 3.4.11.1) LAP PF14_0439 PF3D7_1446200 CATH P09668 Homo sapiens (Human) 5.07623052087166 5.32216666666667 10 10 0 Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] CTSH CPSB PDE9A O76083 Homo sapiens (Human) 6.67244046973034 5.2064402173913 23 24 0 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) PDE9A ENPP2 Q13822 Homo sapiens (Human) 4.50527864538219 5.1584262167317 50 71 0 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD) ENPP2 ATX PDNP2 BRCA1 P38398 Homo sapiens (Human) 5.26866423042786 5.15130575009542 5499 5519 58.0105473722495 Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) BRCA1 RNF53 ADH7 P40394 Homo sapiens (Human) 4.61295299324845 5.0675 4 16 0 Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Retinol dehydrogenase) ADH7 GBRB2 P47870 Homo sapiens (Human) 5.55194546871929 5.23969078947368 95 1362 2.10526315789474 Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) GABRB2 DHSO Q00796 Homo sapiens (Human) 5.98894402317854 5.18679166666667 6 6 16.6666666666667 Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD LEG8 O00214 Homo sapiens (Human) 3.86240507599309 5.2025 5 5 0 Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 SCN4A P35499 Homo sapiens (Human) 5.80484174728034 5.05790937497282 54 67 0 Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) SCN4A SEPR Q12884 Homo sapiens (Human) 4.91552028001666 5.25080078125 32 32 0 Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)] FAP KCMB1 Q16558 Homo sapiens (Human) 3.03962152963204 4.88333333333333 1 6 0 Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit beta-1) (K(VCA)beta-1) (Maxi K channel subunit beta-1) (Slo-beta-1) (Slo-beta) KCNMB1 SUIS P14410 Homo sapiens (Human) 5.315 5.30375 6 6 0 Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)] SI LRRK2 Q5S007 Homo sapiens (Human) 6.01720351323748 5.30297399702718 183 289 0.546448087431694 Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 CASP5 P51878 Homo sapiens (Human) 5.00028967451601 5.234375 3 3 0 Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10] CASP5 ICH3 EPHB6 O15197 Homo sapiens (Human) 5.33142857142857 5.38857142857143 7 8 0 Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6) EPHB6 HIF1N Q9NWT6 Homo sapiens (Human) 4.72333333333333 5.195 3 3 33.3333333333333 Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) HIF1AN FIH1 DUSTY Q6XUX3 Homo sapiens (Human) 5.42833333333333 5.37208333333333 6 6 0 Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P HPSE Q9Y251 Homo sapiens (Human) 6.01259482979244 5.08391129032258 31 36 0 Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 LMBL4 Q8NA19 Homo sapiens (Human) 4.09823705116963 5.217875 5 8 0 Lethal(3)malignant brain tumor-like protein 4 (H-l(3)mbt-like protein 4) (L(3)mbt-like protein 4) (L3mbt-like 4) L3MBTL4 NAGPA Q9UK23 Homo sapiens (Human) 4.43766881124511 5.34166666666667 3 3 0 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA PCSK4 Q6UW60 Homo sapiens (Human) 6.205 4.95 6 6 0 Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 PDE11 Q9HCR9 Homo sapiens (Human) 5.46153212750968 5.26702380952381 14 14 0 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A) PDE11A NISCH Q9Y2I1 Homo sapiens (Human) 7.48653846153846 5.16151442307692 13 23 0 Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 MRP1 P33527 Homo sapiens (Human) 3.70970912178212 5.18189795411947 50 55 4 Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 HASP Q8TF76 Homo sapiens (Human) 5.40368835754245 5.07231119791667 32 51 25 Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase) HASPIN GSG2 PD2R2 Q9Y5Y4 Homo sapiens (Human) 6.86696350616392 5.32269299888281 114 169 0 Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) PTGDR2 CRTH2 DL1R GPR44 DLK1 P80370 Homo sapiens (Human) 5 5.44583333333333 3 3 0 Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)] DLK1 DLK ATD2B Q9ULI0 Homo sapiens (Human) 7.2 4.9975 1 2 0 ATPase family AAA domain-containing protein 2B ATAD2B KIAA1240 DCLK2 Q8N568 Homo sapiens (Human) 4.49757012972289 5.22549131944444 60 92 13.3333333333333 Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2) DCLK2 DCAMKL2 DCDC3B DCK2 MMP17 Q9ULZ9 Homo sapiens (Human) 4 4.925 1 1 0 Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) MMP17 MT4MMP SC6A9 P28572 Rattus norvegicus (Rat) 5.11212505143414 5.13197916666667 4 6 0 Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) Slc6a9 SCN7A Q01118 Homo sapiens (Human) 5.44 5.52287874528033 1 10 0 Sodium channel protein type 7 subunit alpha (Putative voltage-gated sodium channel subunit alpha Nax) (Sodium channel protein cardiac and skeletal muscle subunit alpha) (Sodium channel protein type VII subunit alpha) SCN7A SCN6A SC6A5 Q9Y345 Homo sapiens (Human) 5.02533056689464 5.2905303030303 11 11 0 Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 TRYG1 Q9NRR2 Homo sapiens (Human) 7.58950799129486 5.57701388888889 27 93 0 Tryptase gamma (EC 3.4.21.-) (Serine protease 31) (Transmembrane tryptase) [Cleaved into: Tryptase gamma light chain; Tryptase gamma heavy chain] TPSG1 PRSS31 TMT 5HT4R Q13639 Homo sapiens (Human) 6.90464277591372 5.33792687908496 34 86 0 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 NR1H3 Q13133 Homo sapiens (Human) 4.38144037578051 5.2156139520202 22 37 0 Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) NR1H3 LXRA MTOR Q9JLN9 Mus musculus (Mouse) 8.2 5.375 3 3 0 Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) Mtor Frap Frap1 TERA P55072 Homo sapiens (Human) 5.24215953512698 5.2589375 40 51 2.5 Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) VCP ITK Q08881 Homo sapiens (Human) 4.6952320873811 5.27228663194445 240 318 3.75 Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) ITK EMT LYK FINC P02751 Homo sapiens (Human) 7.48 5.025 1 1 0 Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3] FN1 FN POL P03355 Moloney murine leukemia virus (isolate Shinnick) (MoMLV) 5.03204977729148 4.95833333333333 3 3 0 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pol AROQ P9WPX7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.81 5.675 2 2 0 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) aroQ aroD Rv2537c MTCY159.19 SETD7 Q8WTS6 Homo sapiens (Human) 3.45381546180161 5.44729166666667 9 9 0 Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) SETD7 KIAA1717 KMT7 SET7 SET9 SC6A9 P48067 Homo sapiens (Human) 6.10425699024475 5.26621141975309 27 30 0 Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 ETHR P9WMC1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.80442703880034 5.49583333333333 3 3 0 HTH-type transcriptional regulator EthR ethR etaR Rv3855 ETHR A0R666 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 5 4.95 1 1 100 HTH-type transcriptional regulator EthR ethR MSMEG_6441 MSMEI_6273 LMBL1 Q9Y468 Homo sapiens (Human) 3.66909369760357 5.30722870655916 2248 2338 26.6903914590747 Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1) L3MBTL1 KIAA0681 L3MBT L3MBTL ACHA9 Q9UGM1 Homo sapiens (Human) 5.7 4.95 1 2 0 Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 NACHRA9 CGAT1 Q8TDX6 Homo sapiens (Human) 4.52714238447696 5.18533653846154 13 13 0 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1) CSGALNACT1 CHGN GALNACT1 UNQ656/PRO1287 S27A2 O14975 Homo sapiens (Human) 2 5.40604166666667 3 3 0 Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase) SLC27A2 ACSVL1 FACVL1 FATP2 VLACS SPAT5 Q8NB90 Homo sapiens (Human) 2 5.5 1 1 0 Spermatogenesis-associated protein 5 (ATPase family protein 2 homolog) (Spermatogenesis-associated factor protein) SPATA5 AFG2 SPAF PARP4 Q9UKK3 Homo sapiens (Human) 4 5.09125 1 1 0 Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL MRP2 Q92887 Homo sapiens (Human) 5.08792821325586 5.20194444444444 9 11 44.4444444444444 Canalicular multispecific organic anion transporter 1 (ATP-binding cassette sub-family C member 2) (Canalicular multidrug resistance protein) (Multidrug resistance-associated protein 2) ABCC2 CMOAT CMOAT1 CMRP MRP2 CP2A6 P11509 Homo sapiens (Human) 3.06936521335484 5.27064140468843 126 241 21.4285714285714 Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I)) CYP2A6 CYP2A3 CARM1 Q86X55 Homo sapiens (Human) 5.97257858793287 5.32444444444444 12 15 0 Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) CARM1 PRMT4 CALCA P06881 Homo sapiens (Human) 5.98285714285714 5.60464285714286 7 10 0 Calcitonin gene-related peptide 1 (Alpha-type CGRP) (Calcitonin gene-related peptide I) (CGRP-I) CALCA CALC1 AK1C4 P17516 Homo sapiens (Human) 4.5177705323431 5.20769805560718 21 22 0 Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.357) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) AKR1C4 CHDR AK1C3 P42330 Homo sapiens (Human) 5.64344198108326 5.3354545597042 94 111 3.19148936170213 Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Indanol dehydrogenase) (EC 1.1.1.112) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS KDM3A Q9Y4C1 Homo sapiens (Human) 4.55714285714286 5.30014285714286 7 7 0 Lysine-specific demethylase 3A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) KDM3A JHDM2A JMJD1 JMJD1A KIAA0742 TSGA ADH4 P08319 Homo sapiens (Human) 4.18332450827898 5.0675 4 16 0 Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain) ADH4 KMT2A Q03164 Homo sapiens (Human) 4.08698087189924 5.3395957038377 7684 33014 29.7631441957314 Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 NEK2 P51955 Homo sapiens (Human) 3.76274778515059 5.25654984643379 232 299 3.87931034482759 Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) NEK2 NEK2A NLK1 CXCR4 P61073 Homo sapiens (Human) 6.63398413373592 5.0730969551282 52 52 0 C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) CXCR4 ENLYS P00720 Enterobacteria phage T4 (Bacteriophage T4) 4 5.7875 1 1 0 Endolysin (EC 3.2.1.17) (Lysis protein) (Lysozyme) (Muramidase) E C5AR1 P21730 Homo sapiens (Human) 5.15011112065364 5.07573678861789 41 49 4.8780487804878 C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88) C5AR1 C5AR C5R1 FUT9 Q9Y231 Homo sapiens (Human) 3.30943257490299 4.84375 4 6 25 Alpha-(1,3)-fucosyltransferase 9 (EC 2.4.1.-) (Fucosyltransferase 9) (Fucosyltransferase IX) (Fuc-TIX) (FucT-IX) (Galactoside 3-L-fucosyltransferase) FUT9 HEXA P06865 Homo sapiens (Human) 4.42737442928006 5.0955 5 9 0 Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) HEXA NMUR2 Q9GZQ4 Homo sapiens (Human) 2.62333333333333 5.16298611111111 9 9 33.3333333333333 Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1) NMUR2 NMU2R TGR1 PAFA Q60963 Mus musculus (Mouse) 6.32882715728492 4.9 1 1 100 Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) Pla2g7 Pafah LPH P09848 Homo sapiens (Human) 4.525 5.17375 2 2 0 Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH GALR1 P47211 Homo sapiens (Human) 6.86986461873911 4.95416666666667 12 16 0 Galanin receptor type 1 (GAL1-R) (GALR-1) GALR1 GALNR GALNR1 AL1B1 P30837 Homo sapiens (Human) 2.40457574905607 5.245625 5 6 0 Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) ALDH1B1 ALDH5 ALDHX AL3A1 P30838 Homo sapiens (Human) 5.66342923460183 5.30555555555556 6 9 0 Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1) ALDH3A1 ALDH3 P2RY2 P41231 Homo sapiens (Human) 4.66288014124529 5.13539682539683 21 31 0 P2Y purinoceptor 2 (P2Y2) (ATP receptor) (P2U purinoceptor 1) (P2U1) (P2U receptor 1) (Purinergic receptor) P2RY2 P2RU1 ABCC8 Q09428 Homo sapiens (Human) 5.87773076483493 5.22716567460317 28 182 0 ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) ABCC8 HRINS SUR SUR1 TDT P04053 Homo sapiens (Human) 4.84011686278272 5.29553571428571 7 7 0 DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase) DNTT TDT DYR1A Q13627 Homo sapiens (Human) 4.54257556159943 5.23750832445944 306 354 2.28758169934641 Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) DYRK1A DYRK MNB MNBH BRD4 O60885 Homo sapiens (Human) 5.13290589917181 5.2344571058705 74 100 0 Bromodomain-containing protein 4 (Protein HUNK1) BRD4 HUNK1 SO2B1 O94956 Homo sapiens (Human) 4.73316129292987 5.28943208323549 15 19 20 Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Solute carrier family 21 member 9) SLCO2B1 KIAA0880 OATP2B1 OATPB SLC21A9 VACHT Q16572 Homo sapiens (Human) 6.05855562529739 5.49920138888889 12 13 0 Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3) SLC18A3 VACHT BRD8 Q9H0E9 Homo sapiens (Human) 5.1 5.41 1 1 0 Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) BRD8 SMAP SMAP2 NEK11 Q8NG66 Homo sapiens (Human) 5.44754129480608 5.13530960648148 36 63 25 Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) NEK11 S22A1 O15245 Homo sapiens (Human) 4.39426091037409 5.22321428571429 7 9 42.8571428571429 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) SLC22A1 OCT1 S22A2 O15244 Homo sapiens (Human) 4.3 6.05 1 1 0 Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) SLC22A2 OCT2 P3C2G O75747 Homo sapiens (Human) 5.33780738601082 5.31208333333333 11 12 0 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (PI3K-C2-gamma) (PtdIns-3-kinase C2 subunit gamma) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-gamma) PIK3C2G NMDE3 Q14957 Homo sapiens (Human) 5.62014168612672 5.21067567567567 37 343 0 Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C) GRIN2C NMDAR2C MOT1 P53985 Homo sapiens (Human) 8.57 5.50166666666666 3 5 0 Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1) SLC16A1 MCT1 TSPO P30536 Homo sapiens (Human) 4.20546218740409 5.477306875813 4 4 0 Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) TSPO BZRP MBR TRFE P02787 Homo sapiens (Human) 4.34464162942403 5.30951388888889 9 9 0 Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) TF PRO1400 TR10A O00220 Homo sapiens (Human) 7.1 4.95 1 1 0 Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) TNFRSF10A APO2 DR4 TRAILR1 FUBP2 Q92945 Homo sapiens (Human) 5 4.95 1 5 0 Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75) KHSRP FUBP2 KDM6B O15054 Homo sapiens (Human) 4.60444444444444 5.3210787037037 9 9 0 Lysine-specific demethylase 6B (EC 1.14.11.-) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) KDM6B JMJD3 KIAA0346 WDR5 P61964 Homo sapiens (Human) 5.98604333395276 5.15660609431271 7 10 0 WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) WDR5 BIG3 CSK21 P68400 Homo sapiens (Human) 4.62224380363871 5.25482584760201 301 619 2.6578073089701 Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) CSNK2A1 CK2A1 PTN7 P35236 Homo sapiens (Human) 4.58183834917544 5.35921200980392 85 95 15.2941176470588 Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) PTPN7 KHK P50053 Homo sapiens (Human) 5.31026170411639 5.20274621212121 11 12 0 Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase) KHK PGH1 P23219 Homo sapiens (Human) 4.26120759545624 5.31010200007435 377 629 8.22281167108753 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 SO1B2 Q9QZX8 Rattus norvegicus (Rat) 5.27572413039921 4.925 1 1 0 Solute carrier organic anion transporter family member 1B2 (Liver-specific organic anion transporter 1) (rLST-1) (Sodium-independent organic anion-transporting polypeptide 4) (OATP-4) (Solute carrier family 21 member 10) Slco1b2 Oatp1b2 Slc21a10 TMPS4 Q9NRS4 Homo sapiens (Human) 4.084 5.068 5 5 0 Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) TMPRSS4 TMPRSS3 UNQ776/PRO1570 P55G Q92569 Homo sapiens (Human) 6.26818181818182 5.14962121212121 11 88 0 Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) PIK3R3 P85B O00459 Homo sapiens (Human) 6.26818181818182 5.14962121212121 11 88 0 Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) PIK3R2 PA2G3 Q9NZ20 Homo sapiens (Human) 2 4.85 1 2 0 Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 CATC P53634 Homo sapiens (Human) 7.53211131186435 5.41233704620463 101 119 0 Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC CPPI KLK4 Q9Y5K2 Homo sapiens (Human) 5.9401744600884 4.95 4 4 0 Kallikrein-4 (EC 3.4.21.-) (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17) KLK4 EMSP1 PRSS17 PSTS MPRI P11717 Homo sapiens (Human) 7.05 4.95 1 1 0 Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) IGF2R MPRI MMP11 P24347 Homo sapiens (Human) 2 5.6025 2 2 0 Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) MMP11 STMY3 LX15B O15296 Homo sapiens (Human) 4.92050782553849 5.37089508815911 912 922 34.2105263157895 Arachidonate 15-lipoxygenase B (15-LOX-B) (EC 1.13.11.33) (15-lipoxygenase 2) (15-LOX-2) (Arachidonate 15-lipoxygenase type II) (Linoleate 13-lipoxygenase 15-LOb) (EC 1.13.11.-) ALOX15B LIPC P11150 Homo sapiens (Human) 6.93 5.439865625 80 82 0 Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C) LIPC HTGL FA12 P00748 Homo sapiens (Human) 4.68365658509771 5.30305505050505 165 190 23.6363636363636 Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)] F12 ANM3 O60678 Homo sapiens (Human) 5.03853715826767 5.29895386373491 11 11 0 Protein arginine N-methyltransferase 3 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) PRMT3 HRMT1L3 STK39 Q9UEW8 Homo sapiens (Human) 5 5.38857142857143 7 8 0 STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 SPAK PRP4B Q13523 Homo sapiens (Human) 5.38666666666667 5.37208333333333 6 6 0 Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) PRPF4B KIAA0536 PRP4 PRP4H PRP4K PI42C Q8TBX8 Homo sapiens (Human) 4.96159352681534 5.31714285714286 7 7 0 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) PIP4K2C PIP5K2C VWF P04275 Homo sapiens (Human) 5.42736643009573 4.95 2 4 0 von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] VWF F8VWF NQO2 P16083 Homo sapiens (Human) 5.72308051751602 5.19146527777778 51 82 3.92156862745098 Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) NQO2 NMOR2 RPGF3 O95398 Homo sapiens (Human) 4.3316814057233 5.30977316823831 1718 1786 18.9755529685681 Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) RAPGEF3 CGEF1 EPAC EPAC1 CAN2 P17655 Homo sapiens (Human) 6.64678571428571 5.19575892857142 14 15 0 Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) CAPN2 CANPL2 HSP7C P11142 Homo sapiens (Human) 3.66161479076029 5.81894345238095 14 14 21.4285714285714 Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) HSPA8 HSC70 HSP73 HSPA10 AK1BA O60218 Homo sapiens (Human) 6.02380116073527 5.34375 10 15 0 Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 NOTC3 Q9UM47 Homo sapiens (Human) 8.61 4.909375 2 2 0 Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] NOTCH3 NTCP2 Q12908 Homo sapiens (Human) 5.63532069460997 5.27022727272727 11 13 0 Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2) SLC10A2 ASBT ISBT NTCP2 SMG1 Q96Q15 Homo sapiens (Human) 8.0582059991328 5.096 5 5 0 Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (61E3.4) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) SMG1 ATX KIAA0421 LIP O15826 O15826 Leishmania major 3.50307035192679 4.8125 1 1 0 DUTPase (EC 3.6.1.23) (Putative deoxyuridine triphosphatase) dut DUT LMJF_06_0560 BGAL P00722 Escherichia coli (strain K12) 4.71193498150039 4.925 1 1 0 Beta-galactosidase (Beta-gal) (EC 3.2.1.23) (Lactase) lacZ b0344 JW0335 SCN9A Q15858 Homo sapiens (Human) 6.41427007081921 5.17550406799988 208 235 0 Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) SCN9A NENA UHRF1 Q96T88 Homo sapiens (Human) 4.56400529824273 5.28277777777778 9 18 0 E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) UHRF1 ICBP90 NP95 RNF106 BXA1 A5HZZ9 Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) 4.48389000275929 5.19734848484848 11 17 27.2727272727273 Botulinum neurotoxin type A (BoNT/A) (EC 3.4.24.69) (Bontoxilysin-A) (BOTOX) [Cleaved into: Botulinum neurotoxin A light chain; Botulinum neurotoxin A heavy chain] botA CBO0806 CLC_0862 MMP7 P09237 Homo sapiens (Human) 5.19908167599623 5.28232843137255 51 58 0 Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase) MMP7 MPSL1 PUMP1 UDB15 P54855 Homo sapiens (Human) 3.93215484334533 5.078125 2 3 0 UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3) UGT2B15 UGT2B8 PLM1 P39898 Plasmodium falciparum 6.57057574905607 5.19125 10 10 0 Plasmepsin-1 (EC 3.4.23.38) (Aspartic hemoglobinase I) (PfAPG) SCRB1 Q61009 Mus musculus (Mouse) 5.00875718675764 5.41926851851852 18 22 22.2222222222222 Scavenger receptor class B member 1 (SRB1) (SR-BI) Scarb1 Srb1 PSB8 P28062 Homo sapiens (Human) 3.79896451597527 6.45296052631579 2 38 0 Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein) PSMB8 LMP7 PSMB5i RING10 Y2 DEF1A Q9FV53 Arabidopsis thaliana (Mouse-ear cress) 3.325777187729 5.128 5 5 0 Peptide deformylase 1A, chloroplastic/mitochondrial (AtDEF1) (AtPDF1A) (PDF 1A) (EC 3.5.1.88) (Polypeptide deformylase) PDF1A DEF1 At1g15390 F9L1.34 F9L1_34 TAU P10636 Homo sapiens (Human) 4.94051809132593 5.29546040445357 8019 11004 40.5536849981294 Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) MAPT MAPTL MTBT1 TAU ABCBB Q9QY30 Mus musculus (Mouse) 3.72124639904717 5.6875 1 1 0 Bile salt export pump (ATP-binding cassette sub-family B member 11) (Sister of P-glycoprotein) Abcb11 Bsep Spgp 5HT3D Q70Z44 Homo sapiens (Human) 6.91008769117749 5.35854288339837 50 294 0 5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D) HTR3D DXR P9WNS1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.13874019321122 5.44875 8 11 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) dxr Rv2870c MTCY274.01c BRD2 P25440 Homo sapiens (Human) 5.10613146110076 5.2263943452381 28 32 0 Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein) BRD2 KIAA9001 RING3 5HT1A Q64264 Mus musculus (Mouse) 5.30102999566398 5.3875 1 1 0 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A) Htr1a Gpcr18 5HT1D Q61224 Mus musculus (Mouse) 3.93930215964639 5.6875 1 1 0 5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin receptor 1D) Htr1d Gpcr14 5HT2C P34968 Mus musculus (Mouse) 5.87586653876605 5.46 5 14 0 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) Htr2c 5ht1c Htr1c AA2BR Q60614 Mus musculus (Mouse) 5.1843943546948 5.18125 3 3 0 Adenosine receptor A2b Adora2b ACHA6 Q9R0W9 Mus musculus (Mouse) 8.25 4.85 1 9 0 Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 ACM2 Q9ERZ4 Mus musculus (Mouse) 3.81967245880756 5.4515625 4 25 0 Muscarinic acetylcholine receptor M2 Chrm2 Chrm-2 ACM5 Q920H4 Mus musculus (Mouse) 3.81967245880756 5.4515625 4 25 0 Muscarinic acetylcholine receptor M5 Chrm5 ACSA Q9QXG4 Mus musculus (Mouse) 5.9139773003029 5.4 1 5 100 Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) Acss2 Acas2 Acecs1 AKT1 P31750 Mus musculus (Mouse) 4.767757498916 5.8525 4 4 0 RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene) Akt1 Akt Rac CHLE Q03311 Mus musculus (Mouse) 4.57 6.175 1 2 0 Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) Bche CLK1 P22518 Mus musculus (Mouse) 5.8125 5.52830729166667 8 8 0 Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY) Clk1 Clk Sty CLK2 O35491 Mus musculus (Mouse) 6.85 5.26125 2 2 0 Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) Clk2 CP7A1 Q64505 Mus musculus (Mouse) 5.05271334132872 5.4 1 4 100 Cholesterol 7-alpha-monooxygenase (EC 1.14.14.23) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cytochrome P450 7A1) Cyp7a1 Cyp7 DCOR P00860 Mus musculus (Mouse) 5.41489097788847 5.07625 6 15 0 Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc DRD2 P61168 Mus musculus (Mouse) 5.642 5.406875 5 5 0 D(2) dopamine receptor (Dopamine D2 receptor) Drd2 AOFA Q64133 Mus musculus (Mouse) 2.41355048560802 5.37239583333333 18 19 16.6666666666667 Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) Maoa ADA1A P97718 Mus musculus (Mouse) 7 6.0625 1 3 0 Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) Adra1a Adra1c ABCA1 P41233 Mus musculus (Mouse) 6.07176470588235 4.95 17 17 0 ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 AOFB Q8BW75 Mus musculus (Mouse) 2.30326667461919 5.34707291666667 20 24 30 Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) Maob GRIA3 Q9Z2W9 Mus musculus (Mouse) 4.4050458197032 5.32439102564103 13 100 0 Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) Gria3 Glur3 Kiaa4184 GRIA4 Q9Z2W8 Mus musculus (Mouse) 4.4050458197032 5.32439102564103 13 100 0 Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) Gria4 Glur4 GPAT1 Q61586 Mus musculus (Mouse) 4.735 5.09999999999999 4 4 0 Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) (P90) Gpam Gpat1 HYEP Q9D379 Mus musculus (Mouse) 5 4.8125 1 1 0 Epoxide hydrolase 1 (EC 3.3.2.9) (Epoxide hydratase) (Microsomal epoxide hydrolase) (mEH) Ephx1 MMP9 P41245 Mus musculus (Mouse) 4.05787874528034 5.01875 2 2 50 Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) Mmp9 Clg4b MSHR Q01727 Mus musculus (Mouse) 6.51396915131155 4.96191037735849 53 56 0 Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R) Mc1r Msh-r MC4R P56450 Mus musculus (Mouse) 6.43539388537754 4.95022727272727 55 74 0 Melanocortin receptor 4 (MC4-R) Mc4r LOX5 P48999 Mus musculus (Mouse) 5.109 5.14625 10 10 10 Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) Alox5 HDAC6 Q9Z2V5 Mus musculus (Mouse) 7.155 5.30625 2 2 0 Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Histone deacetylase mHDA2) Hdac6 GBRA6 P16305 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit alpha-6 (GABA(A) receptor subunit alpha-6) Gabra6 Gabra-6 PK3CA P42337 Mus musculus (Mouse) 7.725 5.289125 10 10 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) Pik3ca PPBT P09242 Mus musculus (Mouse) 2 5.26625 4 4 0 Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase 2) (Alkaline phosphatase liver/bone/kidney isozyme) Alpl Akp-2 Akp2 S6A11 P31650 Mus musculus (Mouse) 4.43996653642763 5.24274038461538 13 20 0 Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11) Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4 SC6A2 O55192 Mus musculus (Mouse) 5.66 5.5625 1 1 0 Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2) Slc6a2 SMO P56726 Mus musculus (Mouse) 6.72 4.8125 1 1 0 Smoothened homolog (SMO) Smo Smoh SOAT1 Q61263 Mus musculus (Mouse) 4.73270254186441 5.2875 10 15 10 Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Soat1 Acact SSR3 P30935 Mus musculus (Mouse) 8.25 4.95 1 5 0 Somatostatin receptor type 3 (SS-3-R) (SS3-R) (SS3R) (SSR-28) Sstr3 Smstr3 SSR5 O08858 Mus musculus (Mouse) 8.25 4.95 1 5 0 Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) Sstr5 Smstr5 NR1H4 Q60641 Mus musculus (Mouse) 2 5.1375 1 1 0 Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) Nr1h4 Bar Fxr Rip14 NOS3 P70313 Mus musculus (Mouse) 3.56729981812554 4.98333333333333 3 3 0 Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII) Nos3 Ecnos SC6A4 Q60857 Mus musculus (Mouse) 5.55 5.5625 1 1 0 Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) Slc6a4 Htt Sert SRC P05480 Mus musculus (Mouse) 5.6 4.8125 2 4 50 Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) Src TNF11 O35235 Mus musculus (Mouse) 5 4.95 1 3 100 Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form] Tnfsf11 Opgl Rankl Trance CASP2 P42575 Homo sapiens (Human) 4.04575749056067 5.4125 1 1 0 Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 NEDD2 ST1A1 P50225 Homo sapiens (Human) 5.90587156438028 5.425 1 4 100 Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) SULT1A1 STP STP1 OK/SW-cl.88 SMYD2 Q9NRG4 Homo sapiens (Human) 6.14999353833004 5.32083333333333 3 11 0 N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.43) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2) SMYD2 KMT3C PVDQ Q9I194 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.67745254440752 5.30248320659244 46 57 34.7826086956522 Acyl-homoserine lactone acylase PvdQ (AHL acylase PvdQ) (Acyl-HSL acylase PvdQ) (EC 3.5.1.97) [Cleaved into: Acyl-homoserine lactone acylase PvdQ subunit alpha (Acyl-HSL acylase PvdQ subunit alpha); Acyl-homoserine lactone acylase PvdQ subunit beta (Acyl-HSL acylase PvdQ subunit beta)] pvdQ qsc112 PA2385 GRIK3 P42264 Rattus norvegicus (Rat) 4.46616142630311 5.34257204861111 120 610 0.833333333333333 Glutamate receptor ionotropic, kainate 3 (GluK3) (Glutamate receptor 7) (GluR-7) (GluR7) Grik3 Glur7 FAS P49327 Homo sapiens (Human) 5.71642146726697 5.36672756363806 131 198 12.2137404580153 Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS MRCKB Q9Y5S2 Homo sapiens (Human) 4.58644223118814 5.26932291666667 68 117 10.2941176470588 Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta) CDC42BPB KIAA1124 ACACB O00763 Homo sapiens (Human) 6.50292410042318 5.30429188278279 107 111 0 Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACACB ACC2 ACCB ASAP1 Q9ULH1 Homo sapiens (Human) 4.50354622952223 5.2246875 8 8 50 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) ASAP1 DDEF1 KIAA1249 BIOA P9WQ81 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.43873494167783 5.2851724137931 29 29 20.6896551724138 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase) bioA Rv1568 MTCY336.35c WNK3 Q9BYP7 Homo sapiens (Human) 5.86542647627888 5.13031609195402 29 47 31.0344827586207 Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) WNK3 KIAA1566 PRKWNK3 KIT P05532 Mus musculus (Mouse) 6.35 4.9875 1 1 0 Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117) Kit Sl PADI4 Q9UM07 Homo sapiens (Human) 3.09495204738056 5.41630859375 4 11 0 Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV) PADI4 PAD4 PADI5 PDI5 PDE10 Q9Y233 Homo sapiens (Human) 7.54787872389604 5.29219946808511 235 250 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35) PDE10A ALDH2 P05091 Homo sapiens (Human) 5.13460452522298 5.19859601449275 23 31 4.34782608695652 Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) ALDH2 ALDM BIRC5 O15392 Homo sapiens (Human) 3.33535221589772 5.15416666666667 3 4 0 Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) BIRC5 API4 IAP4 SO2A1 Q00910 Rattus norvegicus (Rat) 6.829 5.07124999999999 10 10 0 Solute carrier organic anion transporter family member 2A1 (Matrin F/G 1) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) Slco2a1 Matr1 Slc21a2 PCSK5 Q92824 Homo sapiens (Human) 6.385 4.95 6 6 0 Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 GLSK O94925 Homo sapiens (Human) 4.8676795024082 5.32741405857624 2424 2435 19.7194719471947 Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) GLS GLS1 KIAA0838 TLR9 Q9EQU3 Mus musculus (Mouse) 2.45 5.15410833333333 10 20 0 Toll-like receptor 9 (CD antigen CD289) Tlr9 HS71A P0DMV8 Homo sapiens (Human) 4.26791666666667 5.96861111111111 12 18 16.6666666666667 Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) HSPA1A HSP72 HSPA1 HSX70 PTPRG P23470 Homo sapiens (Human) 4.07394958320545 5.5375 6 6 0 Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) PTPRG PTPG B2CL1 Q07817 Homo sapiens (Human) 5.71847231930149 5.14526486423192 66 70 4.54545454545455 Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) BCL2L1 BCL2L BCLX LPXC P47205 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 7.81819060454659 5.2716935483871 31 31 0 UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase) lpxC envA PA4406 HSP12 P06582 Caenorhabditis elegans 4.29300725452332 5.26398936170213 47 76 59.5744680851064 Heat shock protein Hsp-16.2 hsp-16.2 hsp16-2 Y46H3A.3 TRYB1 Q15661 Homo sapiens (Human) 7.42070304644635 5.48261513157895 38 105 0 Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1) TPSAB1 TPS1 TPS2 TPSB1 TNKS1 O95271 Homo sapiens (Human) 5.93311550255355 5.21946857193732 36 65 13.8888888888889 Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 5HT2C P28335 Homo sapiens (Human) 5.15344998151383 5.29689523466606 344 596 8.43023255813953 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C) HTR2C HTR1C PEPA5 P0DJD9 Homo sapiens (Human) 8.1375 5.2 4 5 0 Pepsin A-5 (EC 3.4.23.1) (Pepsinogen-5) PGA5 CARP2 P0CS83 Candida albicans (Yeast) 4.80473008522605 5.54735208333333 4 10 0 Candidapepsin-2 (EC 3.4.23.24) (ACP 2) (Aspartate protease 2) (Secreted aspartic protease 2) SAP2 PRA11 PRA2 Q965D7 Q965D7 Plasmodium falciparum 2.87428571428571 4.99690476190476 7 8 42.8571428571429 Beta-hydroxyacyl-ACP dehydratase (Fatty acid synthesis protein) fabZ Q9BJF5 Q9BJF5 Toxoplasma gondii 7.00291514981121 5.33865166666667 25 25 0 Calmodulin-domain protein kinase 1 CDPK1 ESR2 O08537 Mus musculus (Mouse) 4.77077552055858 5.07291666666667 6 20 0 Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) Esr2 Estrb Nr3a2 DPP3 Q9NY33 Homo sapiens (Human) 4.52287874528034 5.0475 1 1 0 Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) DPP3 CA2D2 Q9NY47 Homo sapiens (Human) 7.23 5.17916666666667 1 1 0 Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 PLPL6 Q3TRM4 Mus musculus (Mouse) 5 5.375 1 1 0 Neuropathy target esterase (EC 3.1.1.5) (Patatin-like phospholipase domain-containing protein 6) Pnpla6 Nte FIMH P08191 Escherichia coli (strain K12) 6.07333333333333 5.29509259259259 9 9 0 Type 1 fimbrin D-mannose specific adhesin (Protein FimH) fimH b4320 JW4283 MC3R P41968 Homo sapiens (Human) 3.76267681705167 5.16881628232495 129 226 20.9302325581395 Melanocortin receptor 3 (MC3-R) MC3R P2RX7 Q99572 Homo sapiens (Human) 6.44599958840665 5.21756233367813 114 130 0.87719298245614 P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 AADAT Q8N5Z0 Homo sapiens (Human) 7.34807692307692 5.62081730769231 13 29 0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Kynurenine aminotransferase II) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II) AADAT KAT2 PAR14 Q460N5 Homo sapiens (Human) 4.37738200260161 5.22575 5 6 0 Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Q38C91 Q38C91 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 4.83609962948477 5.20971726190476 21 42 28.5714285714286 Methionyl-tRNA synthetase, putative (EC 6.1.1.10) Tb10.70.6470 MAP11 P53582 Homo sapiens (Human) 4.08461171142711 5.19524224806202 43 59 9.30232558139535 Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) METAP1 KIAA0094 ACM1 P12657 Mus musculus (Mouse) 4.9575361845659 5.480546875 8 29 0 Muscarinic acetylcholine receptor M1 Chrm1 Chrm-1 ADAM8 P78325 Homo sapiens (Human) 2 5.6025 2 2 0 Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) ADAM8 MS2 GBRG1 Q9R0Y8 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit gamma-1 (GABA(A) receptor subunit gamma-1) Gabrg1 GBRG3 P27681 Mus musculus (Mouse) 3.98091975849227 5.325 4 60 0 Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) Gabrg3 INSR P15208 Mus musculus (Mouse) 5.005 5.03125 2 2 0 Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Insr DOT1L Q8TEK3 Homo sapiens (Human) 4.45428571428571 5.52559523809524 7 17 0 Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) DOT1L KIAA1814 KMT4 OGT1 O15294 Homo sapiens (Human) 4.65900773823514 5.24833333333333 6 6 16.6666666666667 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) OGT PLPL9 P97819 Mus musculus (Mouse) 5 5.375 1 1 0 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) Pla2g6 Pnpla9 GBRR2 P28476 Homo sapiens (Human) 4.45593195564972 5.3625 1 3 0 Gamma-aminobutyric acid receptor subunit rho-2 (GABA(A) receptor subunit rho-2) (GABA(C) receptor) GABRR2 M3K5 Q99683 Homo sapiens (Human) 5.36896726392047 5.19383771929825 57 84 17.5438596491228 Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) MAP3K5 ASK1 MAPKKK5 MEKK5 KC1D P48730 Homo sapiens (Human) 4.40819823570364 5.23055496250542 200 258 5.5 Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) CSNK1D HCKID NPCL1 Q9UHC9 Homo sapiens (Human) 5.1 5.4875 2 2 0 Niemann-Pick C1-like protein 1 NPC1L1 BIRC2 Q13490 Homo sapiens (Human) 6.42510506773375 5.2423731884058 23 35 0 Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 FGF1 P05230 Homo sapiens (Human) 6.55695824699331 5.03405172413793 29 29 0 Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) FGF1 FGFA MK13 O15264 Homo sapiens (Human) 3.93310723770018 5.27273152173913 230 489 3.04347826086957 Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) MAPK13 PRKM13 SAPK4 CBG P08185 Homo sapiens (Human) 5 5.425 1 1 100 Corticosteroid-binding globulin (CBG) (Serpin A6) (Transcortin) SERPINA6 CBG TRPM8 Q8R4D5 Mus musculus (Mouse) 2 4.9625 1 1 0 Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) Trpm8 Ltrpc6 Trpp8 AMPN P15145 Sus scrofa (Pig) 5.29981426020546 5.4401689453125 128 143 0.78125 Aminopeptidase N (AP-N) (pAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (gp130) (CD antigen CD13) ANPEP TRXR3 Q86VQ6 Homo sapiens (Human) 4.44 5.33375 5 15 0 Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) TXNRD3 TGR TRXR3 HCAR3 P49019 Homo sapiens (Human) 4.24017679647272 5.32900133042837 57 65 0 Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2) HCAR3 GPR109B HCA3 HM74B NIACR2 ITPR1 Q14643 Homo sapiens (Human) 5.335 4.8375 1 6 0 Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) ITPR1 INSP3R1 ACEA P0CT06 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) 3.74655286890065 5.1375 3 3 0 Isocitrate lyase (ICL) (Isocitrase) (Isocitratase) (EC 4.1.3.1) (Methylisocitrate lyase) (MICA) (EC 4.1.3.30) (Threo-D(S)-isocitrate glyoxylate-lyase) ICL1 MGG_04895 CALCR P30988 Homo sapiens (Human) 2 5.25591400559892 75 150 36 Calcitonin receptor (CT-R) CALCR 5HT2B Q02152 Mus musculus (Mouse) 5.62983317345756 5.5578125 4 13 0 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (5-HT-2F) (NP75 protein) (Serotonin receptor 2B) Htr2b SSR4 P49660 Mus musculus (Mouse) 8.25 4.95 1 5 0 Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 Smstr4 LOX15 Q02759 Rattus norvegicus (Rat) 5.03666666666667 5.13333333333334 3 3 0 Arachidonate 15-lipoxygenase (15-LOX) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate omega-6 lipoxygenase) Alox15 Alox12l SRC Q9WUD9 Rattus norvegicus (Rat) 6.85 4.8375 1 1 0 Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) Src FADS1 O60427 Homo sapiens (Human) 5.78039206469598 5.24717013888889 12 12 0 Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) FADS1 FADSD5 CRFR2 Q60748 Mus musculus (Mouse) 7.18364059638593 4.99818181818182 22 66 0 Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (CRF-RB) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) Crhr2 Crf2r CRFR2 P47866 Rattus norvegicus (Rat) 7.939 6.30375 10 38 0 Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) Crhr2 Crf2r PAR15 Q460N3 Homo sapiens (Human) 4.65965666811201 5.20333333333333 6 8 0 Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 3BHS P9WQP7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4 5.65 1 1 0 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (Cholesterol dehydrogenase) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (3-beta-HSD) (3BHSD) (EC 1.1.1.145) (3-beta hydroxysterol dehydrogenase) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] Rv1106c A85C P9WQN9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 3 5.0675 3 3 0 Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C) fbpC mpt45 Rv0129c MTCI5.03c ACEA P9WKK7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.37333798223158 5.1259375 6 9 0 Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) icl Rv0467 MTV038.11 ALR P9WQA9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 3.02287874528034 4.85 1 2 100 Alanine racemase (EC 5.1.1.1) alr Rv3423c MTCY78.06 CP51 P9WPP9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.9375 5.325 4 4 0 Lanosterol 14-alpha demethylase (EC 1.14.13.70) (CYPLI) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (Sterol 14-alpha demethylase) cyp51 Rv0764c MTCY369.09c CP125 P9WPP1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2 4.85 1 1 0 Steroid C26-monooxygenase (EC 1.14.13.141) (Cholest-4-en-3-one 26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 125) (Steroid C27-monooxygenase) cyp125 cyp125A1 Rv3545c MTCY03C7.11 CP130 P9WPN5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2 4.85 1 1 0 Cytochrome P450 130 (EC 1.14.-.-) cyp130 Rv1256c MTCY50.26 INHA P9WGR1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.34202247002566 5.24146725992375 59 87 5.08474576271187 Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (Enoyl-ACP reductase) (EC 1.3.1.9) (FAS-II enoyl-ACP reductase) (NADH-dependent 2-trans-enoyl-ACP reductase) inhA Rv1484 MTCY277.05 MSHB P9WJN3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.30349723027014 5.34513888888889 9 11 0 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (GlcNAc-Ins deacetylase) (EC 3.5.1.103) (N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) mshB Rv1170 MTCA1 P9WPJ7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.97866666666667 5.18361111111111 15 15 0 Beta-carbonic anhydrase 1 (Beta-CA 1) (EC 4.2.1.1) (Carbonate dehydratase 1) (mtCA 1) mtcA1 canA Rv1284 MTCY373.03 MTCA2 P9WPJ9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.48333333333333 5.35972222222222 3 3 0 Carbonic anhydrase 2 (Beta-CA 2) (EC 4.2.1.1) (Carbonate dehydratase 2) (mtCA 2) mtcA2 canB cynT Rv3588c MTR P9WHH3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2 5.35416666666667 1 1 0 Mycothione reductase (EC 1.8.1.15) (Mycothiol-disulfide reductase) (NADPH-dependent mycothione reductase) mtr gorA Rv2855 PKNF P9WI75 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5 5.64375 4 4 0 Serine/threonine-protein kinase PknF (EC 2.7.11.1) pknF Rv1746 MTCY28.09 RIR1 P9WH75 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.08 4.85 1 1 0 Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit) nrdE Rv3051c MTV012.66c PTPA P9WIA1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.62012419708226 5.18262587135994 22 30 0 Probable low molecular weight protein-tyrosine-phosphatase (PTPase) (EC 3.1.3.48) ptpA Rv2234 MTCY427.15 CHMU P9WIC1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.51165372185964 5.04916666666667 6 7 0 Intracellular chorismate mutase (CM) (EC 5.4.99.5) Rv0948c MTCY10D7.26 SCMU P9WIB9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.78268121368906 5.1075 2 2 0 Secreted chorismate mutase (*MtCM) (CM) (EC 5.4.99.5) Rv1885c CYSK P9WP55 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.22373793013264 5.15727272727273 11 14 0 O-acetylserine sulfhydrylase (OAS sulfhydrylase) (OASS) (EC 2.5.1.47) (Cysteine synthase A) (CSase A) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine-specific cysteine synthase) (Sulfide-dependent cysteine synthase) cysK1 cysK Rv2334 MTCY98.03 THYX P9WG57 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.24990319575991 5.49999999999999 2 4 0 Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase) thyX Rv2754c MTV002.19c DAPA P9WP25 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 5.03238351758129 4.9875 3 3 0 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) dapA Rv2753c MTV002.18c DDL P9WP31 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4 4.85 1 3 100 D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanine:D-alanine ligase) (D-alanylalanine synthetase) ddl ddlA Rv2981c MTCY349.06 TRXB P9WHH1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.53785075437741 5.10833333333333 3 13 0 Thioredoxin reductase (TR) (TRXR) (EC 1.8.1.9) trxB trxB2 Rv3913 MTV028.04 TYSY P9WFR9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.26337792409772 5.49999999999999 2 4 0 Thymidylate synthase ThyA (TS) (TSase) (EC 2.1.1.45) thyA Rv2764c MTV002.29c FAA28 P9WQ59 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.49268478018834 5.33636363636364 44 44 34.0909090909091 Long-chain-fatty-acid--AMP ligase FadD28 (FAAL) (EC 6.2.1.-) (Acyl-AMP synthetase) fadD28 acoas Rv2941 FAB1 P9WQD9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.63202321470541 4.92291666666666 2 2 0 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase 1) (KAS 1) kasA Rv2245 MTCY427.26 FAB2 P9WQD7 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2.66666666666667 4.93541666666667 3 3 0 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase 2) (KAS 2) kasB Rv2246 MTCY427.27 DXS P9WNS3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 3.86948500216801 5.10104166666667 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) dxs Rv2682c MTCY05A6.03c EPHA6 Q9UF33 Homo sapiens (Human) 4.98831101980149 5.30810606060606 11 16 9.09090909090909 Ephrin type-A receptor 6 (EC 2.7.10.1) (EPH homology kinase 2) (EHK-2) (EPH-like kinase 12) (EK12) EPHA6 EHK2 HEK12 PGH1 Q8HZR1 Canis lupus familiaris (Dog) (Canis familiaris) 4.75841199826559 5.38916666666667 5 5 0 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 ABCB5 Q2M3G0 Homo sapiens (Human) 5 5.2375 1 1 0 ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) ABCB5 DCAM1 P0DMN7 Mus musculus (Mouse) 5.35251920008311 5.24 6 7 0 S-adenosylmethionine decarboxylase proenzyme 1 (AdoMetDC 1) (SAMDC 1) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase 1 alpha chain; S-adenosylmethionine decarboxylase 1 beta chain] Amd1 EGLN1 P59722 Rattus norvegicus (Rat) 6.82 5.245 2 2 0 Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (Fragment) Egln1 MANA C0HJB3 Canavalia ensiformis (Jack bean) (Dolichos ensiformis) 5 5.4625 1 1 0 Alpha-mannosidase (JBM) (Jbalpha-man) (EC 3.2.1.24) [Cleaved into: Alpha-mannosidase, heavy subunit; Alpha-mannosidase, light subunit] PGH1 P05979 Ovis aries (Sheep) 4.47613131929931 5.25008208905595 219 260 1.36986301369863 Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) PTGS1 COX1 FLT3 Q00342 Mus musculus (Mouse) 5 5.175 1 1 0 Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135) Flt3 Flk-2 Flt-3 I23O2 Q8R0V5 Mus musculus (Mouse) 5.0871501757189 5.390625 4 4 25 Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-) (Indoleamine 2,3-dioxygenase-like protein 1) (Indoleamine-pyrrole 2,3-dioxygenase-like protein 1) Ido2 Indol1 SC6A5 P58295 Rattus norvegicus (Rat) 5.36333333333333 4.97083333333333 3 3 0 Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 KCNQ1 O70344 Cavia porcellus (Guinea pig) 7.38 5.22375 2 2 0 Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 KVLQT1 VL1 P03101 Human papillomavirus type 16 7.32 4.95 1 1 0 Major capsid protein L1 L1 PI4KA P42356 Homo sapiens (Human) 5.32699514323912 5.33847091194969 53 212 0 Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) PI4KA PIK4 PIK4CA CTRB1 P17538 Homo sapiens (Human) 4.1872754480672 5.10421875 8 9 0 Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] CTRB1 CTRB SC6A1 P30531 Homo sapiens (Human) 5.57540779655652 4.9375 1 1 0 Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 5HT1E P28566 Homo sapiens (Human) 5.28136311941074 5.4246875 20 54 0 5-hydroxytryptamine receptor 1E (5-HT-1E) (5-HT1E) (S31) (Serotonin receptor 1E) HTR1E A4 P05067 Homo sapiens (Human) 5.85569005124943 5.23214082773191 112 152 5.35714285714286 Amyloid-beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] APP A4 AD1 ACM1 P11229 Homo sapiens (Human) 4.67283984427037 5.30731455113346 275 598 9.45454545454546 Muscarinic acetylcholine receptor M1 CHRM1 ACM2 P08172 Homo sapiens (Human) 4.49684795865104 5.28956246915594 190 484 14.2105263157895 Muscarinic acetylcholine receptor M2 CHRM2 ACM3 P20309 Homo sapiens (Human) 4.48755706288873 5.30085186463753 200 515 13.5 Muscarinic acetylcholine receptor M3 CHRM3 ACM5 P08911 Rattus norvegicus (Rat) 6.20493933067099 5.32671639016131 108 969 1.85185185185185 Muscarinic acetylcholine receptor M5 Chrm5 Chrm-5 APEX1 P27695 Homo sapiens (Human) 5.84832553209277 5.3102296054936 5501 5659 16.9969096527904 DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial] APEX1 APE APE1 APEX APX HAP1 REF1 AVR2A P27037 Homo sapiens (Human) 5 5.36768518518518 9 12 11.1111111111111 Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA) ACVR2A ACVR2 C1S P09871 Homo sapiens (Human) 5.22920062310299 5.49703125 16 16 12.5 Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] C1S CNR1 P21554 Homo sapiens (Human) 4.53977722258304 5.32255400149173 251 402 11.1553784860558 Cannabinoid receptor 1 (CB-R) (CB1) (CANN6) CNR1 CNR CD1D P15813 Homo sapiens (Human) 4.77083333333333 5.25624999999999 12 56 0 Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d) CD1D SCN1A P04774 Rattus norvegicus (Rat) 5.33581949932629 5.21963541666667 16 76 0 Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) Scn1a DRD2 P14416 Homo sapiens (Human) 5.60100549102581 5.23960094919328 417 628 6.71462829736211 D(2) dopamine receptor (Dopamine D2 receptor) DRD2 DRD1 P21728 Homo sapiens (Human) 4.29292622155406 5.30141665511831 207 350 20.2898550724638 D(1A) dopamine receptor (Dopamine D1 receptor) DRD1 DHI1 P28845 Homo sapiens (Human) 6.50677229270715 5.30022395833333 160 215 0.625 Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1) HSD11B1 HSD11 HSD11L SDR26C1 NR1D1 P20393 Homo sapiens (Human) 5.20944530601376 5.29625 5 12 0 Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) NR1D1 EAR1 HREV THRAL EDNRB P24530 Homo sapiens (Human) 5.79495374044147 5.36573106564485 183 192 0 Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) EDNRB ETRB FABPH P05413 Homo sapiens (Human) 4.85122248164253 5.03392857142857 7 7 0 Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) (Mammary-derived growth inhibitor) (MDGI) (Muscle fatty acid-binding protein) (M-FABP) FABP3 FABP11 MDGI G3P P04406 Homo sapiens (Human) 4.20543938266718 5.25733683605673 178 183 7.30337078651685 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) GAPDH GAPD CDABP0047 OK/SW-cl.12 HEPS P05981 Homo sapiens (Human) 6.89333333333333 5.22916666666667 3 3 0 Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] HPN TMPRSS1 HRH2 P25021 Homo sapiens (Human) 3.19295097114862 5.30141030213754 120 196 22.5 Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 E2AK2 P19525 Homo sapiens (Human) 5.04635765165609 5.14654647435898 26 29 7.69230769230769 Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase) EIF2AK2 PKR PRKR LOX15 P12530 Oryctolagus cuniculus (Rabbit) 2.34925925925926 5.2734234619743 81 153 27.1604938271605 Arachidonate 15-lipoxygenase (15-LOX) (EC 1.13.11.33) (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (L-12LO) (EC 1.13.11.31) (Arachidonate omega-6 lipoxygenase) (Erythroid cell-specific 15-lipoxygenase) ALOX15 NK3R P29371 Homo sapiens (Human) 6.89109593906218 5.0892895968791 31 50 0 Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R SC6A1 P23978 Rattus norvegicus (Rat) 3.20597718523608 5.20624999999999 2 12 0 Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 NPY1R P25929 Homo sapiens (Human) 4.88204097184868 5.1137770385923 270 372 13.7037037037037 Neuropeptide Y receptor type 1 (NPY1-R) NPY1R NPYR NPYY1 PA21B P04054 Homo sapiens (Human) 4.91017135426613 5.38301987044264 45 52 24.4444444444444 Phospholipase A2 (EC 3.1.1.4) (Group IB phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 1B) PLA2G1B PLA2 PLA2A PPLA2 PTAFR P25105 Homo sapiens (Human) 2.29745228562744 5.29133194944348 84 168 32.1428571428571 Platelet-activating factor receptor (PAF-R) (PAFr) PTAFR PAFR PPAP P15309 Homo sapiens (Human) 4.32190169788251 5.36854166666667 12 13 0 Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39] ACPP PRIO P04156 Homo sapiens (Human) 5.2914749274709 5.18342688117011 33 33 21.2121212121212 Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230) PRNP ALTPRP PRIP PRP RARA P10276 Homo sapiens (Human) 6.69601872457255 5.22801136363636 11 16 0 Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) RARA NR1B1 TRYP P00761 Sus scrofa (Pig) 4.98921052631579 5.33235357464698 38 38 21.0526315789474 Trypsin (EC 3.4.21.4) TPA P00750 Homo sapiens (Human) 4.92791518729353 5.36474558080808 66 69 0 Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] PLAT RPOB P0A8V2 Escherichia coli (strain K12) 4.20105533137358 5.10534722222222 9 136 0 DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) rpoB groN nitB rif ron stl stv tabD b3987 JW3950 CISY2 P08679 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4.7344198154049 5.125 10 10 30 Citrate synthase, peroxisomal (EC 2.3.3.16) CIT2 YCR005C YCR043 YCR5C ASM P17405 Homo sapiens (Human) 4.54492457388288 5.34005050573861 1985 1987 31.2846347607053 Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase) SMPD1 ASM 5HT1A P08908 Homo sapiens (Human) 6.36063148959778 5.27947495306691 213 291 4.22535211267606 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A) HTR1A ADRB2RL1 ADRBRL1 AGTR1 P30556 Homo sapiens (Human) 5.92769651989281 5.23847288849563 133 182 10.5263157894737 Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1) AGTR1 AGTR1A AGTR1B AT2R1 AT2R1B CDK16 Q00536 Homo sapiens (Human) 5.59933940517229 5.25119047619048 14 19 7.14285714285714 Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 NMT P30418 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 4.55 5.39375 2 2 0 Glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase) (NMT) (Peptide N-myristoyltransferase) NMT1 CAALFM_C401440WA CaO19.12111 CaO19.4641 GRM4 P31423 Rattus norvegicus (Rat) 3.77345506554998 5.4348446969697 55 84 0 Metabotropic glutamate receptor 4 (mGluR4) Grm4 Gprc1d Mglur4 5HT7R P32305 Rattus norvegicus (Rat) 6.28482196863201 5.38848031242662 20 103 0 5-hydroxytryptamine receptor 7 (5-HT-7) (5-HT7) (5-HT-X) (GPRFO) (Serotonin receptor 7) Htr7 CNR2 P34972 Homo sapiens (Human) 6.03516106547974 5.31235600198811 221 317 0.452488687782805 Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5) CNR2 CB2A CB2B CTNB1 P35222 Homo sapiens (Human) 4.48733708127976 5.18660714285714 14 19 28.5714285714286 Catenin beta-1 (Beta-catenin) CTNNB1 CTNNB OK/SW-cl.35 PRO2286 TRFR P34981 Homo sapiens (Human) 4.97372320595228 5.2775612745098 34 41 35.2941176470588 Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR OPRD P41143 Homo sapiens (Human) 5.09674475763045 5.27637783483802 392 623 12.7551020408163 Delta-type opioid receptor (D-OR-1) (DOR-1) OPRD1 OPRD 5HT2A P35363 Mus musculus (Mouse) 5.9096654385887 5.36048651960784 34 43 2.94117647058824 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 ACM5 P08912 Homo sapiens (Human) 3.97063771478354 5.31731249752073 165 475 16.3636363636364 Muscarinic acetylcholine receptor M5 CHRM5 APJ P35414 Homo sapiens (Human) 5.64444764489291 5.3590625 16 24 6.25 Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) APLNR AGTRL1 APJ DPOLB P06746 Homo sapiens (Human) 4.46584954330645 5.33641105308729 3410 3454 27.0967741935484 DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) POLB HRH1 P35367 Homo sapiens (Human) 4.42779830426082 5.27710445862178 167 250 16.1676646706587 Histamine H1 receptor (H1R) (HH1R) HRH1 PE2R4 P35408 Homo sapiens (Human) 6.08495271103442 5.17582614942529 29 36 0 Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 RORA P35398 Homo sapiens (Human) 3.94475651420489 5.41498376471239 7 12 0 Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha) RORA NR1F1 RZRA DRD3 P35462 Homo sapiens (Human) 5.47213659679455 5.28349463259875 330 490 11.2121212121212 D(3) dopamine receptor (Dopamine D3 receptor) DRD3 V1AR P37288 Homo sapiens (Human) 4.28060417132267 5.21761891888783 153 241 18.3006535947712 Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) AVPR1A AVPR1 KCNJ5 P48544 Homo sapiens (Human) 5.46949419632365 5.31862125054201 2 6 0 G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) KCNJ5 GIRK4 DDR1 Q08345 Homo sapiens (Human) 5.94835647007812 5.23295343137255 17 20 5.88235294117647 Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE CDN1A P38936 Homo sapiens (Human) 4.85127900303521 5.0535 5 12 0 Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1 5HT2B P41595 Homo sapiens (Human) 4.73021306795645 5.28001425543888 216 400 12.962962962963 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) HTR2B ADA1D P23944 Rattus norvegicus (Rat) 6.35587115228874 5.30428777978863 246 806 0 Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (RA42) Adra1d Adra1a MP2K4 P45985 Homo sapiens (Human) 5.01232835246724 5.43003205128205 13 16 7.69230769230769 Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1 5HT5A P47898 Homo sapiens (Human) 5.04963799447406 5.34239937504279 76 109 9.21052631578947 5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A) HTR5A DRD4 P21917 Homo sapiens (Human) 4.56586773900368 5.26730570810654 187 342 14.4385026737968 D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor) DRD4 DAC P15555 Streptomyces sp. (strain R61) 2 5.21250000000001 2 2 0 D-alanyl-D-alanine carboxypeptidase (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) LEG7 P47929 Homo sapiens (Human) 2.49954189441705 5.2225 5 5 0 Galectin-7 (Gal-7) (HKL-14) (PI7) (p53-induced gene 1 protein) LGALS7 PIG1; LGALS7B MTR1A P48039 Homo sapiens (Human) 7.01052215185496 5.18970315995526 149 241 0 Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) MTNR1A ADA2A P08913 Homo sapiens (Human) 4.44493668956846 5.23861401127884 185 355 15.1351351351351 Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) ADRA2A ADRA2R ADRAR MMP11 Q02853 Mus musculus (Mouse) 8.82 4.87499999999998 1 1 0 Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) Mmp11 CXCR2 P25025 Homo sapiens (Human) 3.96750224992553 5.22973211666869 157 274 17.8343949044586 C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182) CXCR2 IL8RB KCNJ1 P48048 Homo sapiens (Human) 6.19333333333333 5.16798611111111 6 6 0 ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1) KCNJ1 ROMK1 B2CL2 Q92843 Homo sapiens (Human) 5.58 4.8625 3 3 0 Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) BCL2L2 BCLW KIAA0271 BLM P54132 Homo sapiens (Human) 5.21407269667967 5.35751919340328 413 577 30.9927360774818 Bloom syndrome protein (EC 3.6.4.12) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3) BLM RECQ2 RECQL3 BMX P51813 Homo sapiens (Human) 4.62200263145342 5.2396914556962 79 134 12.6582278481013 Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) BMX CATG P28293 Mus musculus (Mouse) 4.4 4.8375 1 1 0 Cathepsin G (EC 3.4.21.20) (Vimentin-specific protease) (VSP) Ctsg CLK2 P49760 Homo sapiens (Human) 4.35735288046283 5.26568587276617 227 281 3.52422907488987 Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 PDE4A P54748 Rattus norvegicus (Rat) 7.52305708925833 5.584625 5 44 0 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) Pde4a HYES P34914 Mus musculus (Mouse) 5.27333333333333 5.575 6 6 0 Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] Ephx2 Eph2 MP2K6 P52564 Homo sapiens (Human) 5.51351399366174 5.20908234126984 42 66 23.8095238095238 Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 PRKX P51817 Homo sapiens (Human) 4.18390411913358 5.26215491598194 186 241 4.83870967741936 cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) PRKX PKX1 KLK7 P49862 Homo sapiens (Human) 4.72714351198421 5.24816506410256 52 58 15.3846153846154 Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE) KLK7 PRSS6 SCCE EPHA4 P54764 Homo sapiens (Human) 4.78051368140573 5.29078427419355 62 98 11.2903225806452 Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK) EPHA4 HEK8 SEK TYRO1 TYRO3 Q06418 Homo sapiens (Human) 3.91029369338226 5.28588248944344 217 267 3.68663594470046 Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF) TYRO3 BYK DTK RSE SKY TIF GLP1R P43220 Homo sapiens (Human) 5.00153237768739 5.2977336412837 11888 12262 27.4310228802153 Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) GLP1R CASP3 P55213 Rattus norvegicus (Rat) 3.62893213772826 5.2 1 1 0 Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 BKRB2 P30411 Homo sapiens (Human) 3.13421092218523 5.21350609483501 102 192 26.4705882352941 B2 bradykinin receptor (B2R) (BK-2 receptor) BDKRB2 BKR2 STAT1 P42224 Homo sapiens (Human) 5.1583920663923 5.2794212962963 135 143 69.6296296296296 Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) STAT1 PLD2 O14939 Homo sapiens (Human) 6.62270542185529 5.286 15 16 0 Phospholipase D2 (PLD 2) (hPLD2) (EC 3.1.4.4) (Choline phosphatase 2) (PLD1C) (Phosphatidylcholine-hydrolyzing phospholipase D2) PLD2 PHKG1 Q16816 Homo sapiens (Human) 4.22438580319157 5.32658605072464 46 92 2.17391304347826 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26) PHKG1 PHKG CCR6 P51684 Homo sapiens (Human) 3.37426993676123 5.38207955136544 39 41 30.7692307692308 C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (Chemokine receptor-like 3) (CKR-L3) (DRY6) (G-protein coupled receptor 29) (GPR-CY4) (GPRCY4) (LARC receptor) (CD antigen CD196) CCR6 CKRL3 CMKBR6 GPR29 STRL22 AHR P35869 Homo sapiens (Human) 5.10406645976613 5.12102854938272 90 100 35.5555555555556 Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) AHR BHLHE76 MMP16 P51512 Homo sapiens (Human) 3.72 5.286 5 5 0 Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) MMP16 C8orf57 MMPX2 STF1 Q13285 Homo sapiens (Human) 5.25325743027716 5.13455882352941 17 17 5.88235294117647 Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP) NR5A1 AD4BP FTZF1 SF1 CXCR6 O00574 Homo sapiens (Human) 2 4.91249999999999 1 1 0 C-X-C chemokine receptor type 6 (CXC-R6) (CXCR-6) (CDw186) (G-protein coupled receptor STRL33) (G-protein coupled receptor bonzo) (CD antigen CD186) CXCR6 BONZO STRL33 TYMSTR KCC1A Q14012 Homo sapiens (Human) 3.38298972108907 5.2208097943723 154 186 5.84415584415584 Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) CAMK1 PDK3 Q15120 Homo sapiens (Human) 5.44068197440616 5.49806134259259 36 148 0 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) PDK3 PDHK3 TRXR2 Q9Z0J5 Rattus norvegicus (Rat) 3.74232142513082 5.425 1 1 0 Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3) Txnrd2 Trxr2 CDK5 Q00535 Homo sapiens (Human) 4.92467516966479 5.25505188117123 506 985 4.54545454545455 Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) CDK5 CDKN5 AA3R P0DMS8 Homo sapiens (Human) 5.25837079831116 5.24724909981831 593 802 5.56492411467116 Adenosine receptor A3 ADORA3 DNMT1 P26358 Homo sapiens (Human) 4.55746774147981 5.27106707317073 41 42 9.75609756097561 DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) DNMT1 AIM CXXC9 DNMT FPR1 P21462 Homo sapiens (Human) 4.63490317824016 5.64280862403101 86 200 22.093023255814 fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) FPR1 NR5A2 O00482 Homo sapiens (Human) 4.99112245562599 5.13359375 16 16 6.25 Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1) NR5A2 B1F CPF FTF HSPB1 P04792 Homo sapiens (Human) 4.5291915185293 5.23893236113692 126 149 12.6984126984127 Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 PI42B P78356 Homo sapiens (Human) 5.15605810742857 5.30825 10 13 10 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) PIP4K2B PIP5K2B RIPK2 O43353 Homo sapiens (Human) 5.27688459246222 5.18445669934641 51 82 21.5686274509804 Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2) RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092 ADRB1 P08588 Homo sapiens (Human) 4.58903491808424 5.26690755910922 261 490 10.727969348659 Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) ADRB1 ADRB1R B1AR MPIP2 P30305 Homo sapiens (Human) 4.56506847453433 5.20160984848485 66 80 1.51515151515152 M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) CDC25B CDC25HU2 GSTO1 P78417 Homo sapiens (Human) 5 4.85 1 1 0 Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 GSTTLP28 RGS4 P49798 Homo sapiens (Human) 4.36458506030519 5.31860762323596 1947 1964 23.0611196712892 Regulator of G-protein signaling 4 (RGP4) (RGS4) RGS4 SMAD3 P84022 Homo sapiens (Human) 5.02632433801179 5.29931988520536 6232 6500 23.0744544287548 Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) SMAD3 MADH3 LYPA1 O75608 Homo sapiens (Human) 7.2 5.31875 2 2 0 Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) LYPLA1 APT1 LPL1 DCLK1 O15075 Homo sapiens (Human) 2.55337013334267 5.23857230392157 102 105 0.980392156862745 Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) DCLK1 DCAMKL1 DCDC3A KIAA0369 FAAH1 O08914 Mus musculus (Mouse) 5.65051499783199 5.2125 2 2 0 Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1) Faah Faah1 PA1B3 Q61205 Mus musculus (Mouse) 5 5.375 1 1 0 Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma) Pafah1b3 Pafahg CP2C9 P11712 Homo sapiens (Human) 3.40005732187154 5.33517149473519 2487 2871 16.043425814234 Cytochrome P450 2C9 (EC 1.14.13.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (EC 1.14.99.38) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) CYP2C9 CYP2C10 GGPPS O95749 Homo sapiens (Human) 4.49730450294602 5.37455882352941 17 44 0 Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) GGPS1 PI42A P48426 Homo sapiens (Human) 4.78418781453991 5.35710185185185 117 117 20.5128205128205 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PIP5K2 PIP5K2A PADI2 Q9Y2J8 Homo sapiens (Human) 4.88493067602787 5.47090277777778 3 7 0 Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) PADI2 KIAA0994 PAD2 PDI2 PPME1 Q9Y570 Homo sapiens (Human) 5.25267693291286 5.2025 4 5 0 Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) PPME1 PME1 PP2593 PRO0750 NOX1 Q9Y5S8 Homo sapiens (Human) 5.19441837685148 5.13784722222222 27 29 3.7037037037037 NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1) NOX1 MOX1 NOH1 CLK4 Q9HAZ1 Homo sapiens (Human) 5.29934216241376 5.22224103750991 314 475 1.91082802547771 Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4) CLK4 IL1B P01584 Homo sapiens (Human) 4.42 4.85 1 1 0 Interleukin-1 beta (IL-1 beta) (Catabolin) IL1B IL1F2 KCNK3 O14649 Homo sapiens (Human) 6.64050018106064 5.4 2 2 0 Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1) (Two pore K(+) channel KT3.1) KCNK3 TASK TASK1 SC5A7 Q9GZV3 Homo sapiens (Human) 5.18644709984926 5.23934309309309 111 147 21.6216216216216 High affinity choline transporter 1 (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7) SLC5A7 CHT1 NOTC1 P46531 Homo sapiens (Human) 7.62570708490655 4.99291666666667 3 3 0 Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 AMPC P24735 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 4.69404482088348 5.92258333333333 5 9 0 Beta-lactamase (EC 3.5.2.6) (Cephalosporinase) ampC PA4110 GRM8 O00222 Homo sapiens (Human) 4.5862010392078 5.39170138888889 36 48 11.1111111111111 Metabotropic glutamate receptor 8 (mGluR8) GRM8 GPRC1H MGLUR8 S1PR1 P21453 Homo sapiens (Human) 7.13105446779782 5.33410466269841 168 207 2.38095238095238 Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) S1PR1 CHEDG1 EDG1 SAE2 Q9UBT2 Homo sapiens (Human) 4.75552264808363 5.17166158536585 41 123 26.8292682926829 SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) UBA2 SAE2 UBLE1B HRIHFB2115 PEBB Q13951 Homo sapiens (Human) 4.7836330632872 5.30618470551564 1037 2170 36.4513018322083 Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) CBFB CASP6 P55212 Homo sapiens (Human) 5.05112218680002 5.39725595238095 56 56 10.7142857142857 Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 MCH2 FACE2 Q9Y256 Homo sapiens (Human) 5.02630072073289 5.28805555555556 36 36 22.2222222222222 CAAX prenyl protease 2 (EC 3.4.22.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1) RCE1 FACE2 RCE1A RCE1B CP3A4 P08684 Homo sapiens (Human) 3.45913466398952 5.33864786629892 2740 3782 17.2627737226277 Cytochrome P450 3A4 (EC 1.14.13.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.13.157) (Albendazole monooxygenase) (EC 1.14.13.32) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (EC 1.14.14.1) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.13.67) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97) CYP3A4 CYP3A3 RARB P10826 Homo sapiens (Human) 4.5814346804829 5.23384803921569 17 21 0 Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) RARB HAP NR1B2 S1PR4 O95977 Homo sapiens (Human) 5.59842589917315 5.21674536274667 58 73 6.89655172413793 Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6) S1PR4 EDG6 HDA10 Q969S8 Homo sapiens (Human) 5.70001167509309 5.31699770210104 223 3703 0.896860986547085 Histone deacetylase 10 (HD10) (EC 3.5.1.98) HDAC10 HRH3 Q9Y5N1 Homo sapiens (Human) 6.63916924984965 5.28885232868622 135 173 0 Histamine H3 receptor (H3R) (HH3R) (G-protein coupled receptor 97) HRH3 GPCR97 GAK O14976 Homo sapiens (Human) 5.09877185719146 5.23787689138349 25 36 4 Cyclin-G-associated kinase (EC 2.7.11.1) GAK BGAL Q8VNN2 Escherichia coli 4.35158865352441 5.3084964380263 106 114 31.1320754716981 Beta-galactosidase (Beta-gal) (EC 3.2.1.23) (Lactase) lacZ KC1G1 Q9HCP0 Homo sapiens (Human) 4.00768863667397 5.23966981132076 159 224 5.0314465408805 Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) CSNK1G1 MEN1 O00255 Homo sapiens (Human) 4.37724742433585 5.33735256763978 6031 26152 31.7691925053888 Menin MEN1 SCG2 ERR1 P11474 Homo sapiens (Human) 5.1869029995664 5.31663725490196 10 15 10 Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1) ESRRA ERR1 ESRL1 NR3B1 HDAC9 Q9UKV0 Homo sapiens (Human) 5.56913391787527 5.3211435062027 222 3699 0.900900900900901 Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR) HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR PTN22 Q9Y2R2 Homo sapiens (Human) 4.44125343216672 5.26020497311828 62 102 17.741935483871 Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP) PTPN22 PTPN8 TLR4 O00206 Homo sapiens (Human) 3.95903225806452 5.18440860215054 31 34 0 Toll-like receptor 4 (hToll) (CD antigen CD284) TLR4 TAAR1 Q96RJ0 Homo sapiens (Human) 5.3592104836757 5.29196632420091 73 136 21.9178082191781 Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) TAAR1 TA1 TAR1 TRAR1 ERAP1 Q9NZ08 Homo sapiens (Human) 4.72984276573873 5.35954761904762 35 35 8.57142857142857 Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator) ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154 IDHC O75874 Homo sapiens (Human) 4.80897875959929 5.30406760528844 3858 4024 29.6526697770866 Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 PICD S1PR5 Q9H228 Homo sapiens (Human) 6.62195343728142 5.18259604902286 28 36 0 Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) S1PR5 EDG8 NEK1 Q96PY6 Homo sapiens (Human) 5.19117787816418 5.36216968753388 64 95 1.5625 Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) NEK1 KIAA1901 ACM4 P08173 Homo sapiens (Human) 3.81727968709688 5.28695153724909 177 511 15.819209039548 Muscarinic acetylcholine receptor M4 CHRM4 UBA1 P22314 Homo sapiens (Human) 2.92333333333333 5.18760416666667 6 6 0 Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1) UBA1 A1S9T UBE1 ABHGA Q9Z1Q2 Mus musculus (Mouse) 5 5.375 1 1 0 Protein ABHD16A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) Abhd16a Bat5 Ng26 PA24A P47712 Homo sapiens (Human) 5.92815434062304 5.21448784722222 24 31 0 Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 SRMS Q9H3Y6 Homo sapiens (Human) 2.89234789702356 5.2869126984127 105 122 0.952380952380952 Tyrosine-protein kinase Srms (EC 2.7.10.2) SRMS C20orf148 M4K3 Q8IVH8 Homo sapiens (Human) 5.42123088272628 5.32823863636364 11 15 9.09090909090909 Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) MAP4K3 RAB8IPL1 MARK4 Q96L34 Homo sapiens (Human) 4.170824074158 5.327578125 48 77 2.08333333333333 MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) MARK4 KIAA1860 MARKL1 TSSK1 Q9BXA7 Homo sapiens (Human) 3.64905196762944 5.25883802816902 142 188 6.33802816901408 Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A) TSSK1B SPOGA1 SPOGA4 STK22A STK22D TSSK1 FKSG81 CAH13 Q8N1Q1 Homo sapiens (Human) 6.10105545656675 5.29219696969697 33 145 9.09090909090909 Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII) CA13 DGLB Q91WC9 Mus musculus (Mouse) 5 5.375 1 1 0 Sn1-specific diacylglycerol lipase beta (DGL-beta) (EC 3.1.1.-) Daglb PE2R2 P43116 Homo sapiens (Human) 6.23012300431541 5.37317148663516 22 26 0 Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor) PTGER2 OXYR P30559 Homo sapiens (Human) 7.49557560683416 5.16283700980392 68 79 1.47058823529412 Oxytocin receptor (OT-R) OXTR MCHR1 Q99705 Homo sapiens (Human) 6.11731244351298 5.22987778219216 111 148 2.7027027027027 Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein) MCHR1 GPR24 SLC1 S1PR2 O95136 Homo sapiens (Human) 4.58743852054063 5.1900791718973 40 53 10 Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5) S1PR2 EDG5 ABD12 Q99LR1 Mus musculus (Mouse) 5 5.375 1 1 0 Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 12) Abhd12 OPRK P41145 Homo sapiens (Human) 5.37724475330273 5.30546724500059 322 529 12.111801242236 Kappa-type opioid receptor (K-OR-1) (KOR-1) OPRK1 OPRK ERAP2 Q6P179 Homo sapiens (Human) 4.94127454646779 5.39013888888889 21 21 14.2857142857143 Endoplasmic reticulum aminopeptidase 2 (EC 3.4.11.-) (Leukocyte-derived arginine aminopeptidase) (L-RAP) ERAP2 LRAP SLK Q9H2G2 Homo sapiens (Human) 4.00563948689571 5.23227609034268 107 111 0.934579439252336 STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) SLK KIAA0204 STK2 BMR1A P36894 Homo sapiens (Human) 5.1071769605672 5.27005208333333 12 15 8.33333333333333 Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292) BMPR1A ACVRLK3 ALK3 MDR1 P08183 Homo sapiens (Human) 5.39457795674939 5.23265227766873 149 237 8.05369127516778 Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 KEAP1 Q14145 Homo sapiens (Human) 5.42589044661656 5.3480289328352 87 132 6.89655172413793 Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) KEAP1 INRF2 KIAA0132 KLHL19 NPSR1 Q6W5P4 Homo sapiens (Human) 5.0646333134858 5.36911963519159 1608 1651 36.1940298507463 Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 MUSK O15146 Homo sapiens (Human) 4.56700000701829 5.22881398809524 70 118 14.2857142857143 Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor) MUSK PLK3 Q9H4B4 Homo sapiens (Human) 4.00299112380912 5.20549368686869 165 199 6.06060606060606 Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase) PLK3 CNK FNK PRK NMD3B Q8VHN2 Rattus norvegicus (Rat) 5.33314255164192 5.38317861979197 431 4407 0.464037122969838 Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subtype 3B) (NMDAR3B) (NR3B) Grin3b IF4E P63073 Mus musculus (Mouse) 4.31638725832282 5.48372759856631 93 93 35.4838709677419 Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) Eif4e MK01 P63086 Rattus norvegicus (Rat) 4.95440415202342 5.58211805555555 6 7 0 Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) Mapk1 Erk2 Mapk Prkm1 KCNJ2 P63252 Homo sapiens (Human) 4 4.84875 1 1 0 Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2) KCNJ2 IRK1 FAS P19096 Mus musculus (Mouse) 5 5.375 1 1 0 Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] Fasn PARL Q5XJY4 Mus musculus (Mouse) 5 5.375 1 1 0 Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane-cleaving protease PARL) [Cleaved into: P-beta (Pbeta)] Parl Psarl PADI1 Q9ULC6 Homo sapiens (Human) 4.59054429966225 6.41701388888889 1 3 0 Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I) PADI1 PAD1 PDI1 PADI3 Q9ULW8 Homo sapiens (Human) 4.70904788920423 5.62569444444445 4 8 0 Protein-arginine deiminase type-3 (EC 3.5.3.15) (Peptidylarginine deiminase III) (Protein-arginine deiminase type III) PADI3 PAD3 PDI3 CDK19 Q9BWU1 Homo sapiens (Human) 2.94062380244663 5.21991361788618 41 44 7.31707317073171 Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase) CDK19 CDC2L6 CDK11 KIAA1028 DYR P0A017 Staphylococcus aureus 8.58 6.1225 2 2 0 Dihydrofolate reductase (DHFR) (EC 1.5.1.3) folA MC4R P32245 Homo sapiens (Human) 4.84564038131845 5.18368031083301 248 447 14.5161290322581 Melanocortin receptor 4 (MC4-R) MC4R MARK2 Q7KZI7 Homo sapiens (Human) 3.9102493846879 5.24748244382023 178 224 5.0561797752809 Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b) MARK2 EMK1 ABCG2 Q9UNQ0 Homo sapiens (Human) 5.57854470322727 5.21037113527569 66 103 7.57575757575758 ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) ABCG2 ABCP BCRP BCRP1 MXR ITA4 P13612 Homo sapiens (Human) 7.10920455592004 5.31819133155709 92 256 0 Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) ITGA4 CD49D PPBT P05186 Homo sapiens (Human) 4.69982560027841 5.25109032839072 173 216 15.606936416185 Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme) ALPL FABH P0A6R0 Escherichia coli (strain K12) 3.42539044367231 5.37375 2 2 0 3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthase III) (Beta-ketoacyl-ACP synthase III) (KAS III) (EcFabH) fabH b1091 JW1077 ATM Q13315 Homo sapiens (Human) 4.79493251281482 5.32321205731036 398 440 14.321608040201 Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated) ATM NSD2 O96028 Homo sapiens (Human) 5.07737590169261 5.38333984375 64 64 29.6875 Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein) NSD2 KIAA1090 MMSET TRX5 WHSC1 ST32C Q86UX6 Homo sapiens (Human) 4.87391950062967 5.32241666666667 10 13 10 Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) STK32C YANK3 EPHB2 P29323 Homo sapiens (Human) 4.54697260255714 5.22622950268817 62 98 3.2258064516129 Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5 RBBP9 O88851 Mus musculus (Mouse) 5 5.375 1 1 0 Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 9) (RBBP-9) Rbbp9 Bog PAR4 Q96RI0 Homo sapiens (Human) 5.80931454638058 4.95625 2 4 0 Proteinase-activated receptor 4 (PAR-4) (Coagulation factor II receptor-like 3) (Thrombin receptor-like 3) F2RL3 PAR4 ELNE Q3UP87 Mus musculus (Mouse) 4.59 4.8375 1 1 0 Neutrophil elastase (EC 3.4.21.37) (Elastase-2) (Leukocyte elastase) Elane Ela2 LIMK1 P53667 Homo sapiens (Human) 4.43464841830664 5.25256362155003 206 257 5.33980582524272 LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) LIMK1 LIMK CFTR P13569 Homo sapiens (Human) 3.97361780575895 5.20343495934959 41 53 2.4390243902439 Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 3.6.3.49) (cAMP-dependent chloride channel) CFTR ABCC7 XDH P80457 Bos taurus (Bovine) 6.50442731151013 5.27744864175789 127 138 1.5748031496063 Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH KPCD1 Q15139 Homo sapiens (Human) 5.25989374231233 5.25818486255387 151 921 5.96026490066225 Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu) PRKD1 PKD PKD1 PRKCM ADA1B P35368 Homo sapiens (Human) 5.96212242257891 5.25214098082219 137 235 0.72992700729927 Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B M3K12 Q12852 Homo sapiens (Human) 5.61625 5.3165625 8 9 0 Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) MAP3K12 ZPK TBB2B Q6B856 Bos taurus (Bovine) 4.97131398535766 5.21229166666667 134 411 2.23880597014925 Tubulin beta-2B chain TUBB2B UBP1 O94782 Homo sapiens (Human) 4.9327995342103 5.30961820212563 2504 2521 18.7300319488818 Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) USP1 CAC1C Q13936 Homo sapiens (Human) 5.37852887847739 5.32216948124157 27 68 7.40740740740741 Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1 O97447 O97447 Giardia intestinalis (Giardia lamblia) 4.90048324742268 5.35331391811608 2328 2468 22.3367697594502 Putative fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) ald GATA Q9CZN8 Mus musculus (Mouse) 5 5.375 1 1 0 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) Qrsl1 ARBK1 P25098 Homo sapiens (Human) 4.25275754304963 5.64166666666667 13 14 15.3846153846154 Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) GRK2 ADRBK1 BARK BARK1 RIOK3 O14730 Homo sapiens (Human) 5.22978984923918 5.35076388888889 12 15 8.33333333333333 Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog) RIOK3 SUDD E2AK3 Q9NZJ5 Homo sapiens (Human) 5.37543587372534 5.21097619047619 35 58 17.1428571428571 Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) EIF2AK3 PEK PERK LTK P29376 Homo sapiens (Human) 4.46452674399861 5.28215390917585 106 136 0.943396226415094 Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) LTK TYK1 MTAP Q13126 Homo sapiens (Human) 6.07658655475459 5.26772321428571 14 15 0 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) MTAP MSAP KAT2A Q92830 Homo sapiens (Human) 5.09522475061374 5.32507718139188 1919 3912 19.2287649817613 Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (HsGCN5) (Lysine acetyltransferase 2A) (STAF97) KAT2A GCN5 GCN5L2 HGCN5 TPA P11214 Mus musculus (Mouse) 5 5.375 1 1 0 Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] Plat SRPK1 Q96SB4 Homo sapiens (Human) 3.84305674461264 5.23482413419914 154 182 5.19480519480519 SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) SRPK1 LATS2 Q9NRM7 Homo sapiens (Human) 5.14888888888889 5.36768518518518 9 12 11.1111111111111 Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) LATS2 KPM MK04 P31152 Homo sapiens (Human) 4.94 5.33016666666667 10 13 10 Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) MAPK4 ERK4 PRKM4 RAD54 Q92698 Homo sapiens (Human) 4.76433271157249 5.274375 40 40 20 DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (RAD54 homolog) (hHR54) (hRAD54) RAD54L RAD54A PLPL7 A2AJ88 Mus musculus (Mouse) 5 5.375 1 1 0 Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (Neuropathy target esterase-related esterase) (NRE) (NTE-related esterase) Pnpla7 RISC Q920A5 Mus musculus (Mouse) 5 5.375 1 1 0 Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) Scpep1 Risc MYLK3 Q32MK0 Homo sapiens (Human) 5.50333333333333 5.37208333333333 6 6 0 Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) MYLK3 MLCK EPHA5 P54756 Homo sapiens (Human) 5.37012096402615 5.17814655172414 29 42 17.2413793103448 Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) EPHA5 BSK EHK1 HEK7 TYRO4 KPYK Q27686 Leishmania mexicana 3.46720157262423 5.33175046158457 1199 2415 69.1409507923269 Pyruvate kinase (PK) (EC 2.7.1.40) PYK RON Q04912 Homo sapiens (Human) 4.52359073199102 5.26354499524727 132 182 6.81818181818182 Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] MST1R PTK8 RON IRAK3 Q9Y616 Homo sapiens (Human) 5.21581879457591 5.32680555555556 12 15 8.33333333333333 Interleukin-1 receptor-associated kinase 3 (IRAK-3) (EC 2.7.11.1) (IL-1 receptor-associated kinase M) (IRAK-M) IRAK3 KCC2B Q13554 Homo sapiens (Human) 4.00636684067663 5.15833783436214 162 281 6.17283950617284 Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) CAMK2B CAM2 CAMK2 CAMKB CDK1 P06493 Homo sapiens (Human) 5.11867404800617 5.23748719020431 499 1175 2.20440881763527 Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) CDK1 CDC2 CDC28A CDKN1 P34CDC2 MARK3 P27448 Homo sapiens (Human) 3.7396246796862 5.25957136015326 174 207 2.29885057471264 MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) MARK3 CTAK1 EMK2 FTSZ P9WN95 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 4.235 5.45 2 2 0 Cell division protein FtsZ ftsZ Rv2150c MTCY270.18 METC P06721 Escherichia coli (strain K12) 4.625 5.325 2 2 0 Cystathionine beta-lyase MetC (CBL) (EC 4.4.1.8) (Beta-cystathionase) (Cysteine lyase) metC b3008 JW2975 Q8RLA6 Q8RLA6 Acinetobacter baumannii 5.22666666666667 5.26 3 3 0 Beta-lactamase (Betalactamase OXA24) (Carbapenem-hydrolyzing beta-lactamase OXA-40) (Carbapenem-hydrolyzing oxacillinase) (Carbapenem-hydrolyzing oxacillinase OXA-40) (Carbapenemase OXA-24) (Class D beta-lactamase OXA-40) (OXA-24 class D beta-lactamase) (EC 3.5.2.6) (OXA24 B-lactamase) (Oxa40) blaOXA-33 bla-OXA-40 blaOXA-24 blaOXA-40 oxa-24 oxa40 BRDT Q58F21 Homo sapiens (Human) 5.1 5.11 2 2 0 Bromodomain testis-specific protein (Cancer/testis antigen 9) (CT9) (RING3-like protein) BRDT Q8DNV6 Q8DNV6 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 7.17 5.0625 2 2 0 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) murF spr1514 TPIS P60174 Homo sapiens (Human) 3.15051499783199 5.3375 2 2 0 Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) TPI1 TPI